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Kah Leong Lim, PhD - Publications

Affiliations: 
2000-2001 Department of Pathology Harvard Medical School, Boston, MA, United States 
 2001-2002 Department of Neurology Johns Hopkins University School of Medicine, Baltimore, MD, United States 
 2009- Neuroscience & Behavioural Disorders Programme Duke-National University of Singapore Graduate Medical School, Singapore 
 2012- National Neuroscience Institute, Singapore 
 2012- Department of Physiology National University of Singapore, Singapore, Singapore 
Area:
Molecular Mechanisms underlying Parkinson’s disease
Website:
https://www.duke-nus.edu.sg/content/lim-kah-leong
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Year Citation  Score
2020 Rajan S, Jang Y, Kim CH, Kim W, Toh HT, Jeon J, Song B, Serra A, Lescar J, Yoo JY, Beldar S, Ye H, Kang C, Liu XW, Feitosa M, ... ... Lim KL, et al. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature Chemical Biology. PMID 32451509 DOI: 10.1038/S41589-020-0553-6  0.352
2020 Sun Q, Xu J, Ji CL, Shaibani MSS, Li Z, Lim K, Zhang CW, Li L, Liu Z. Ultrafast Detection of Peroxynitrite in Parkinson's Disease Models Using a Near-Infrared Fluorescent Probe. Analytical Chemistry. PMID 32028762 DOI: 10.1021/Acs.Analchem.9B05599  0.407
2019 Sim JPL, Ziyin W, Basil AH, Lin S, Chen Z, Zhang C, Zeng L, Cai Y, Lim KL. Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity. Neuromolecular Medicine. PMID 31664682 DOI: 10.1007/S12017-019-08577-Z  0.375
2019 Shani V, Safory H, Szargel R, Wang N, Cohen T, Elghani FA, Hamza H, Savyon M, Radzishevsky I, Shaulov L, Rott R, Lim KL, Ross CA, Bandopadhyay R, Zhang H, et al. Physiological and pathological roles of LRRK2 in the nuclear envelope integrity. Human Molecular Genetics. PMID 31626293 DOI: 10.1093/Hmg/Ddz245  0.449
2019 Ding Y, Kong D, Zhou T, Yang ND, Xin C, Xu J, Wang Q, Zhang H, Wu Q, Lu X, Lim K, Ma B, Zhang C, Li L, Huang W. α-Arbutin Protects Against Parkinson's Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo. Neuromolecular Medicine. PMID 31401719 DOI: 10.1007/S12017-019-08562-6  0.46
2019 Shi R, Wu Q, Xin C, Yu H, Lim K, Li X, Shi Z, Zhang CW, Qian L, Li L, Huang W. Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases. Chembiochem : a European Journal of Chemical Biology. PMID 30664830 DOI: 10.1002/Cbic.201800813  0.317
2019 Toh HT, Rajan S, Yoo JY, Basil A, Wang Z, Goh G, Lim K, Yoon HS. Nurr1 ligands ameliorate behavioural deficits on Parkinson's disease-context in vivo models Ibro Reports. 6. DOI: 10.1016/J.Ibror.2019.07.1486  0.316
2018 Hang L, Thundyil J, Goh GWY, Lim KL. AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression. Neuromolecular Medicine. PMID 30411223 DOI: 10.1007/S12017-018-8517-7  0.766
2018 Weng M, Xie X, Liu C, Lim KL, Zhang CW, Li L. The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease. Parkinson's Disease. 2018: 9163040. PMID 30245802 DOI: 10.1155/2018/9163040  0.44
2018 Ding Y, Xin C, Zhang CW, Lim KL, Zhang H, Fu Z, Li L, Huang W. Natural Molecules From Chinese Herbs Protecting Against Parkinson's Disease via Anti-oxidative Stress. Frontiers in Aging Neuroscience. 10: 246. PMID 30233351 DOI: 10.3389/Fnagi.2018.00246  0.43
2018 Liu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, ... ... Lim KL, et al. S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30104344 DOI: 10.1523/Jneurosci.3262-17.2018  0.327
2018 Tan KKB, Lim WWM, Chai C, Kukumberg M, Lim KL, Goh ELK, Yim EKF. Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells. Scientific Reports. 8: 9567. PMID 29934644 DOI: 10.1038/S41598-018-27653-1  0.328
2018 Wang L, Cho YL, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tong Y, Chawla R, Zhang J, Shi Y, Deng S, Lu G, Wu Y, Tan HW, ... ... Lim KL, et al. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Research. PMID 29934616 DOI: 10.1038/S41422-018-0056-0  0.355
2018 Shao YM, Ma X, Paira P, Tan A, Herr DR, Lim KL, Ng CH, Venkatesan G, Klotz KN, Federico S, Spalluto G, Cheong SL, Chen YZ, Pastorin G. Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment. Plos One. 13: e0188212. PMID 29304113 DOI: 10.1371/Journal.Pone.0188212  0.373
2017 Xiao B, Deng X, Lim GGY, Xie S, Zhou ZD, Lim KL, Tan EK. Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria. Cell Death & Disease. 8: e3097. PMID 29022898 DOI: 10.1038/Cddis.2017.463  0.372
2017 Ng CH, Hang L, Lim KL. Mitochondrial homeostasis in Parkinson's disease - a triumvirate rule? Neural Regeneration Research. 12: 1270-1272. PMID 28966639 DOI: 10.4103/1673-5374.213546  0.346
2017 Basil AH, Sim JPL, Lim GGY, Lin S, Chan HY, Engelender S, Lim KL. AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease. Frontiers in Cellular Neuroscience. 11: 241. PMID 28848400 DOI: 10.3389/Fncel.2017.00241  0.467
2017 Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. The Journal of Biological Chemistry. PMID 28848050 DOI: 10.1074/Jbc.M117.787739  0.37
2017 Chen ZC, Zhang W, Chua LL, Chai C, Li R, Lin L, Cao Z, Angeles DC, Stanton LW, Peng JH, Zhou ZD, Lim KL, Zeng L, Tan EK. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Science Signaling. 10. PMID 28720718 DOI: 10.1126/Scisignal.Aam6790  0.467
2017 Zhang CW, Tai YK, Chai BH, Chew KCM, Ang ET, Tsang F, Tan BWQ, Hong ETE, Asad ABA, Chuang KH, Lim KL, Soong TW. Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain. Neuromolecular Medicine. PMID 28695462 DOI: 10.1007/S12017-017-8451-0  0.337
2017 Lim GG, Lim KL. Parkin-independent mitophagy-FKBP8 takes the stage. Embo Reports. PMID 28515082 DOI: 10.15252/Embr.201744313  0.308
2017 Xiao B, Deng X, Lim GGY, Zhou W, Saw WT, Zhou ZD, Lim KL, Tan EK. p62-Mediated Mitochondrial Clustering Attenuates Apoptosis Induced by Mitochondrial Depolarization. Biochimica Et Biophysica Acta. PMID 28433685 DOI: 10.1016/J.Bbamcr.2017.04.009  0.331
2017 Ng CH, Basil AH, Hang L, Tan R, Goh KL, O'Neill S, Zhang X, Yu F, Lim KL. Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease. Neurobiology of Aging. 55: 33-37. PMID 28407521 DOI: 10.1016/J.Neurobiolaging.2017.03.017  0.438
2016 Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, ... ... Lim KL, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nature Communications. 7: 11792. PMID 27273569 DOI: 10.1038/Ncomms11792  0.572
2016 Gallart-Palau X, Ng CH, Ribera J, Sze SK, Lim KL. Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial Amyotrophic Lateral Sclerosis. Neuroscience Letters. PMID 27163198 DOI: 10.1016/J.Neulet.2016.05.006  0.312
2016 Hang L, Basil AH, Lim KL. Nutraceuticals in Parkinson's Disease. Neuromolecular Medicine. 18: 306-21. PMID 27147525 DOI: 10.1007/S12017-016-8398-6  0.433
2016 Angeles DC, Ho P, Dymock BW, Lim KL, Zhou ZD, Tan EK. Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2. Annals of Clinical and Translational Neurology. 3: 288-94. PMID 27081659 DOI: 10.1002/Acn3.282  0.387
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Lim KL, ... ... Lim K, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.437
2016 Zhang CW, Adeline HB, Chai BH, Hong ET, Ng CH, Lim KL. Pharmacological or Genetic Activation of Hsp70 Protects against Loss of Parkin Function. Neuro-Degenerative Diseases. PMID 26886023 DOI: 10.1159/000443668  0.427
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Lim KL, ... ... Lim K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.655
2016 Philippens IHCHM, Franke SK, Kesteren REv, Hofman S, Wubben JAM, Smit AB, Moldovan A, Südmeyer M, Hammesfahr S, Antke C, Mamlins E, Beu M, Wojtecki L, Ferrea S, Schnitzler A, ... ... Lim K, et al. Contents Vol. 16, 2016 Neurodegenerative Diseases. 16. DOI: 10.1159/000448958  0.376
2016 Sharan P, Angeles DC, Ho P, Dymock BW, Lim K, Tan E. Antioxidant kinase inhibitors for LRRK2 Parkinson's disease Parkinsonism & Related Disorders. 22. DOI: 10.1016/J.Parkreldis.2015.10.403  0.345
2015 Zhang CW, Hang L, Yao TP, Lim KL. Parkin Regulation and Neurodegenerative Disorders. Frontiers in Aging Neuroscience. 7: 248. PMID 26793099 DOI: 10.3389/Fnagi.2015.00248  0.425
2015 Hang L, Thundyil J, Lim KL. Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection. Annals of the New York Academy of Sciences. 1350: 37-47. PMID 26121488 DOI: 10.1111/Nyas.12820  0.759
2015 Lim GG, Chua DS, Basil AH, Chan HY, Chai C, Arumugam T, Lim KL. Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy. The Journal of Biological Chemistry. 290: 16882-93. PMID 25987559 DOI: 10.1074/Jbc.M114.622399  0.342
2015 Thundyil J, Lim KL. DAMPs and neurodegeneration. Ageing Research Reviews. 24: 17-28. PMID 25462192 DOI: 10.1016/J.Arr.2014.11.003  0.722
2014 Li L, Zhang CW, Chen GY, Zhu B, Chai C, Xu QH, Tan EK, Zhu Q, Lim KL, Yao SQ. A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson's disease models. Nature Communications. 5: 3276. PMID 24522637 DOI: 10.1038/Ncomms4276  0.338
2014 Angeles DC, Ho P, Chua LL, Wang C, Yap YW, Ng C, Zhou Zd, Lim KL, Wszolek ZK, Wang HY, Tan EK. Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila. Human Molecular Genetics. 23: 3157-65. PMID 24459295 DOI: 10.1093/Hmg/Ddu026  0.45
2013 Chai C, Lim KL. Genetic insights into sporadic Parkinson's disease pathogenesis. Current Genomics. 14: 486-501. PMID 24532982 DOI: 10.2174/1389202914666131210195808  0.431
2013 Lim GG, Chew KC, Ng XH, Henry-Basil A, Sim RW, Tan JM, Chai C, Lim KL. Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination. Plos One. 8: e73235. PMID 24023840 DOI: 10.1371/Journal.Pone.0073235  0.38
2013 Lim K, Zhang C. Molecular events underlying Parkinson's disease - an interwoven tapestry Frontiers in Neurology. 4: 33-33. PMID 23580245 DOI: 10.3389/Fneur.2013.00033  0.476
2013 Haskin J, Szargel R, Shani V, Mekies LN, Rott R, Lim GG, Lim KL, Bandopadhyay R, Wolosker H, Engelender S. AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease. Human Molecular Genetics. 22: 2083-96. PMID 23393160 DOI: 10.1093/Hmg/Ddt058  0.428
2012 Ng C, Guan MSH, Koh C, Ouyang X, Yu F, Tan E, O'Neill SP, Zhang X, Chung J, Lim K. AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease The Journal of Neuroscience. 32: 14311-14317. PMID 23055502 DOI: 10.1523/Jneurosci.0499-12.2012  0.483
2012 Imai Y, Venderova K, Lim K. Animal Models of Parkinson's Disease 2012 Parkinson's Disease. 2012: 729428-729428. PMID 23029629 DOI: 10.1155/2012/729428  0.451
2012 Yeo CW, Ng FS, Chai C, Tan JM, Koh GR, Chong YK, Koh LW, Foong CS, Sandanaraj E, Holbrook JD, Ang BT, Takahashi R, Tang C, Lim KL. Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival. Cancer Research. 72: 2543-53. PMID 22431710 DOI: 10.1158/0008-5472.Can-11-3060  0.338
2012 Lim KL, Ng XH, Grace LG, Yao TP. Mitochondrial dynamics and Parkinson's disease: focus on parkin. Antioxidants & Redox Signaling. 16: 935-49. PMID 21668405 DOI: 10.1089/Ars.2011.4105  0.404
2011 Angeles DC, Gan BH, Onstead L, Zhao Y, Lim KL, Dachsel J, Melrose H, Farrer M, Wszolek ZK, Dickson DW, Tan EK. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. Human Mutation. 32: 1390-7. PMID 21850687 DOI: 10.1002/Humu.21582  0.457
2011 Chew KC, Ang ET, Tai YK, Tsang F, Lo SQ, Ong E, Ong WY, Shen HM, Lim KL, Dawson VL, Dawson TM, Soong TW. Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease. The Journal of Biological Chemistry. 286: 33380-9. PMID 21795716 DOI: 10.1074/Jbc.M111.268409  0.537
2011 Chew KC, Matsuda N, Saisho K, Lim GG, Chai C, Tan HM, Tanaka K, Lim KL. Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination. Plos One. 6: e19720. PMID 21625422 DOI: 10.1371/Journal.Pone.0019720  0.38
2011 Lim KL, Lim GG. K63-linked ubiquitination and neurodegeneration. Neurobiology of Disease. 43: 9-16. PMID 20696248 DOI: 10.1016/J.Nbd.2010.08.001  0.358
2010 Lim K. Non-mammalian animal models of Parkinson's disease for drug discovery Expert Opinion On Drug Discovery. 5: 165-176. PMID 22822916 DOI: 10.1517/17460440903527675  0.405
2010 Lee JY, Nagano Y, Taylor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. The Journal of Cell Biology. 189: 671-9. PMID 20457763 DOI: 10.1083/Jcb.201001039  0.415
2009 Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL. Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11257-62. PMID 19741132 DOI: 10.1523/Jneurosci.2375-09.2009  0.55
2009 Tan JMM, Wong ESP, Lim K. Protein misfolding and aggregation in Parkinson's disease Antioxidants & Redox Signaling. 11: 2119-2134. PMID 19243238 DOI: 10.1089/Ars.2009.2490  0.454
2009 Lim K, Ng C. Genetic models of Parkinson disease Biochimica Et Biophysica Acta. 1792: 604-615. PMID 19000757 DOI: 10.1016/J.Bbadis.2008.10.005  0.409
2008 de la Iglesia N, Konopka G, Lim KL, Nutt CL, Bromberg JF, Frank DA, Mischel PS, Louis DN, Bonni A. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5870-8. PMID 18524891 DOI: 10.1523/Jneurosci.5385-07.2008  0.672
2008 Wong ES, Tan JM, Soong WE, Hussein K, Nukina N, Dawson VL, Dawson TM, Cuervo AM, Lim KL. Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Human Molecular Genetics. 17: 2570-82. PMID 18502787 DOI: 10.1093/Hmg/Ddn157  0.495
2008 Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, Dawson VL, Dawson TM, Lim KL. Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Human Molecular Genetics. 17: 431-9. PMID 17981811 DOI: 10.1093/Hmg/Ddm320  0.518
2008 Tan JMM, Wong ESP, Dawson VL, Dawson TM, Lim KL. Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy Autophagy. 4: 251-253. DOI: 10.4161/Auto.5444  0.493
2007 Lim K. Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies. Expert Review of Proteomics. 4: 769-781. PMID 18067415 DOI: 10.1586/14789450.4.6.769  0.452
2007 Lim K, Tan JMM. Role of the ubiquitin proteasome system in Parkinson's disease Bmc Biochemistry. 8: 1-10. PMID 18047737 DOI: 10.1186/1471-2091-8-S1-S13  0.452
2007 Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F, Lim KL. Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8563-70. PMID 17687034 DOI: 10.1523/Jneurosci.0218-07.2007  0.414
2007 Wong ES, Tan JM, Wang C, Zhang Z, Tay SP, Zaiden N, Ko HS, Dawson VL, Dawson TM, Lim KL. Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations. The Journal of Biological Chemistry. 282: 12310-8. PMID 17329252 DOI: 10.1074/Jbc.M609466200  0.509
2007 West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Human Molecular Genetics. 16: 223-32. PMID 17200152 DOI: 10.1093/Hmg/Ddl471  0.618
2006 von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3685-96. PMID 16597723 DOI: 10.1523/Jneurosci.0414-06.2006  0.539
2006 Lim KL, Dawson VL, Dawson TM. Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases? Neurobiology of Aging. 27: 524-9. PMID 16213628 DOI: 10.1016/J.Neurobiolaging.2005.07.023  0.591
2005 Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL. Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Human Molecular Genetics. 14: 3885-97. PMID 16278233 DOI: 10.1093/Hmg/Ddi413  0.589
2005 Tan EK, Shen H, Tan JMM, Lim KL, Fook-Chong S, Hu WP, Paterson MC, Chandran VR, Yew K, Tan C, Yuen Y, Pavanni R, Wong MC, Puvan K, Zhao Y. Differential expression of splice variant and wild-type parkin in sporadic Parkinson's disease. Neurogenetics. 6: 179-184. PMID 16086186 DOI: 10.1007/S10048-005-0001-5  0.437
2005 Sriram SR, Li X, Ko HS, Chung KK, Wong E, Lim KL, Dawson VL, Dawson TM. Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Human Molecular Genetics. 14: 2571-86. PMID 16049031 DOI: 10.1093/Hmg/Ddi292  0.759
2005 Wang C, Tan JM, Ho MW, Zaiden N, Wong SH, Chew CL, Eng PW, Lim TM, Dawson TM, Lim KL. Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations. Journal of Neurochemistry. 93: 422-31. PMID 15816865 DOI: 10.1111/J.1471-4159.2005.03023.X  0.573
2005 Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM. Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2002-9. PMID 15728840 DOI: 10.1523/Jneurosci.4474-04.2005  0.564
2004 Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 10744-9. PMID 15249681 DOI: 10.1073/Pnas.0401297101  0.583
2004 von Coelln R, Thomas B, Lim K, Hess E, Lee M, Dawson V, Dawson T. Alpha-Synuclein-induzierte Proteinaggregation und Neurodegeneration in vivo sind Parkin-unabhängig Aktuelle Neurologie. 31. DOI: 10.1055/S-2004-833018  0.441
2003 Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B. SEPT5_v2 is a parkin-binding protein. Brain Research. Molecular Brain Research. 117: 179-89. PMID 14559152 DOI: 10.1016/S0169-328X(03)00318-8  0.53
2003 Pawlyk AC, Giasson BI, Sampathu DM, Perez FA, Lim KL, Dawson VL, Dawson TM, Palmiter RD, Trojanowski JQ, Lee VM. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry. 278: 48120-8. PMID 12972409 DOI: 10.1074/Jbc.M306889200  0.512
2003 Lim KL, Lim TM. Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes. Iubmb Life. 55: 315-322. PMID 12938733 DOI: 10.1080/1521654031000153030  0.439
2003 Lim KL, Dawson VL, Dawson TM. The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects. Annals of the New York Academy of Sciences. 991: 80-92. PMID 12846976 DOI: 10.1111/J.1749-6632.2003.Tb07465.X  0.58
2002 Lim KL, Dawson VL, Dawson TM. The genetics of Parkinson's disease. Current Neurology and Neuroscience Reports. 2: 439-46. PMID 12169225 DOI: 10.1007/S11910-002-0071-9  0.544
2001 Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nature Medicine. 7: 1144-50. PMID 11590439 DOI: 10.1038/Nm1001-1144  0.531
2000 Wang H, Lim KL, Yeo SL, Xu X, Sim MM, Ting AE, Wang Y, Yee S, Tan YH, Pallen CJ. Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces. Journal of Natural Products. 63: 1641-6. PMID 11141106 DOI: 10.1021/NP000293+  0.608
2000 Liang L, Lim KL, Seow KT, Ng CH, Pallen CJ. Calmodulin Binds to and Inhibits the Activity of the Membrane Distal Catalytic Domain of Receptor Protein-tyrosine Phosphatase α Journal of Biological Chemistry. 275: 30075-30081. PMID 10893241 DOI: 10.1074/Jbc.M004843200  0.619
1999 Lim KL, Ng CH, Pallen CJ. Catalytic activation of the membrane distal domain of protein tyrosine phosphatase ϵ, but not CD45, by two point mutations Biochimica Et Biophysica Acta. 1434: 275-283. PMID 10525146 DOI: 10.1016/S0167-4838(99)00189-2  0.301
1999 Ponniah S, Wang DZM, Lim KL, Pallen CJ. Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn Current Biology. 9: 535-538. PMID 10339428 DOI: 10.1016/S0960-9822(99)80238-3  0.637
1998 Lim KL, Kolatkar PR, Ng KP, Ng CH, Pallen CJ. Interconversion of the Kinetic Identities of the Tandem Catalytic Domains of Receptor-like Protein-tyrosine Phosphatase PTPα by Two Point Mutations Is Synergistic and Substrate-dependent Journal of Biological Chemistry. 273: 28986-28993. PMID 9786903 DOI: 10.1074/Jbc.273.44.28986  0.614
1998 Bhandari V, Lim KL, Pallen CJ. Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn. Journal of Biological Chemistry. 273: 8691-8698. PMID 9535845 DOI: 10.1074/Jbc.273.15.8691  0.644
1997 Lim KL, Lai DSY, Kalousek MB, Wang Y, Pallen CJ. Kinetic Analysis Of Two Closely Related Receptor-Like Protein-Tyrosine-Phosphatases, Ptpalpha And Ptpepsilon Febs Journal. 245: 693-700. PMID 9183007 DOI: 10.1111/J.1432-1033.1997.00693.X  0.625
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