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Matthew Farrer, PhD, Imperial College - Publications

Affiliations: 
Neurogenetics and Translational Medicine University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Neurodegenerative diseases
Website:
http://www.cmmt.ubc.ca/research/investigators/farrer/lab
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340 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Guenther DT, Follett J, Amouri R, Sassi SB, Hentati F, Farrer MJ. The Evolution of Genetic Variability at the Locus. Genes. 15. PMID 39062657 DOI: 10.3390/genes15070878  0.342
2024 Deng IB, Follett J, Fox JD, Farrer MJ. Characterization of Dnajc12 knockout mice, a model of hypodopaminergia. Biorxiv : the Preprint Server For Biology. PMID 39026821 DOI: 10.1101/2024.07.06.602343  0.309
2024 Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Portugal B, Lee PC, May P, Bobbili D, Radivojkov Blagojevic M, Lichtner P, Singleton AB, Hernandez D, Edsall C, Mellick GD, ... ... Farrer M, et al. Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study. Neurology. 103: e209620. PMID 38986057 DOI: 10.1212/WNL.0000000000209620  0.699
2024 Tan MMX, Lawton MA, Pollard MI, Brown E, Real R, Carrasco AM, Bekadar S, Jabbari E, Reynolds RH, Iwaki H, Blauwendraat C, Kanavou S, Hubbard L, Malek N, Grosset KA, ... ... Farrer MJ, et al. Genome-wide determinants of mortality and motor progression in Parkinson's disease. Npj Parkinson's Disease. 10: 113. PMID 38849413 DOI: 10.1038/s41531-024-00729-8  0.66
2024 Gopinath A, Ramirez-Zamora A, Franks S, Riaz T, Smith A, Dizon G, Hornstein L, Follett J, Swartz C, Bravo J, Kugelmann EL, Farrer M, Okun MS, Khoshbouei H. Immunophenotyping Tracks Motor Progression in Parkinson's Disease Associated with a TH Mutation. Journal of Parkinson's Disease. PMID 38788089 DOI: 10.3233/JPD-240030  0.41
2024 Gustavsson EK, Follett J, Trinh J, Barodia SK, Real R, Liu Z, Grant-Peters M, Fox JD, Appel-Cresswell S, Stoessl AJ, Rajput A, Rajput AH, Auer R, Tilney R, Sturm M, ... ... Farrer MJ, et al. RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses. The Lancet. Neurology. PMID 38614108 DOI: 10.1016/S1474-4422(24)00121-2  0.39
2024 Gustavsson EK, Follett J, Trinh J, Barodia SK, Real R, Liu Z, Grant-Peters M, Fox JD, Appel-Cresswell S, Stoessl AJ, Rajput A, Rajput AH, Auer R, Tilney R, Sturm M, ... ... Farrer MJ, et al. A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and . Medrxiv : the Preprint Server For Health Sciences. PMID 38293014 DOI: 10.1101/2024.01.17.24300927  0.399
2024 Follett J, Guenther D, Xoi L, Amouri R, Ben Sassi S, Hentati F, Farrer MJ. Genetic Modifiers of LRRK2 Parkinson's Disease: A Replication Study in Arab-Berbers. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 38291980 DOI: 10.1002/mds.29735  0.343
2023 Bu M, Follett J, Deng I, Tatarnikov I, Wall S, Guenther D, Maczis M, Wimsatt G, Milnerwood A, Moehle MS, Khoshbouei H, Farrer MJ. Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice. Npj Parkinson's Disease. 9: 167. PMID 38110354 DOI: 10.1038/s41531-023-00609-7  0.811
2023 Kawakami F, Imai M, Isaka Y, Cookson MR, Maruyama H, Kubo M, Farrer MJ, Kanzaki M, Kawashima R, Maekawa T, Tamaki S, Kurosaki Y, Kojima F, Ohba K, Ichikawa T. LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes. Febs Open Bio. PMID 37845194 DOI: 10.1002/2211-5463.13717  0.437
2023 Müller-Nedebock AC, Dekker MCJ, Farrer MJ, Hattori N, Lim SY, Mellick GD, Rektorová I, Salama M, Schuh AFS, Stoessl AJ, Sue CM, Tan AH, Vidal RL, Klein C, Bardien S. Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease. Npj Parkinson's Disease. 9: 110. PMID 37443150 DOI: 10.1038/s41531-023-00535-8  0.343
2023 Nakahara Y, Mitsui J, Date H, Porto KJ, Hayashi Y, Yamashita A, Kusakabe Y, Matsukawa T, Ishiura H, Yasuda T, Iwata A, Goto J, Ichikawa Y, Momose Y, Takahashi Y, ... ... Farrer MJ, et al. Genome-wide association study identifies a new susceptibility locus in for Multiple System Atrophy. Medrxiv : the Preprint Server For Health Sciences. PMID 37425910 DOI: 10.1101/2023.05.02.23289328  0.387
2023 Gabbert C, Schaake S, Lüth T, Much C, Klein C, Aasly JO, Farrer MJ, Trinh J. GBA1 in Parkinson's disease: variant detection and pathogenicity scoring matters. Bmc Genomics. 24: 322. PMID 37312046 DOI: 10.1186/s12864-023-09417-y  0.391
2023 Vollstedt EJ, Schaake S, Lohmann K, Padmanabhan S, Brice A, Lesage S, Tesson C, Vidailhet M, Wurster I, Hentati F, Mirelman A, Giladi N, Marder K, Waters C, Fahn S, ... ... Farrer MJ, et al. Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 36692014 DOI: 10.1002/mds.29288  0.376
2022 Trinh J, Hicks AA, König IR, Delcambre S, Lüth T, Schaake S, Wasner K, Ghelfi J, Borsche M, Vilariño-Güell C, Hentati F, Germer EL, Bauer P, Takanashi M, Kostić V, ... ... Farrer MJ, et al. Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson's disease. Brain : a Journal of Neurology. PMID 36478228 DOI: 10.1093/brain/awac464  0.318
2022 Berg A, Bech S, Aasly J, Farrer MJ, Skaalum Petersen M. Autonomic dysfunction in Parkinson's disease: Results from the Faroese Parkinson's disease cohort. Neuroscience Letters. 785: 136789. PMID 35835395 DOI: 10.1016/j.neulet.2022.136789  0.326
2022 Johansen M, Joensen S, Restorff M, Stórá T, Christy D, Gustavsson EK, Bian J, Guo Y, Farrer MJ, Petersen MS. Polygenic risk of Alzheimer's disease in the Faroe Islands. European Journal of Neurology. PMID 35384166 DOI: 10.1111/ene.15351  0.792
2021 Lin CH, Farrer MJ, Wu RM. Erratum to: Reply: UQCRC1 variants in Parkinson's disease: a large cohort study in Chinese mainland population. Brain : a Journal of Neurology. PMID 34279032 DOI: 10.1093/brain/awab228  0.304
2021 Lai D, Alipanahi B, Fontanillas P, Schwantes-An TH, Aasly J, Alcalay RN, Beecham GW, Berg D, Bressman S, Brice A, Brockman K, Clark L, Cookson M, Das S, Van Deerlin V, ... ... Farrer MJ, et al. Genome-wide association studies of LRRK2 modifiers of Parkinson's disease. Annals of Neurology. PMID 33938021 DOI: 10.1002/ana.26094  0.832
2021 Farrer MJ, Bardien S, Hattori N, Lesage S, Ross OA, Mellick GD, Kruger R. Editorial: Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson's Disease. Frontiers in Neurology. 12: 648417. PMID 33889126 DOI: 10.3389/fneur.2021.648417  0.303
2021 Bentley SR, Guella I, Sherman HE, Neuendorf HM, Sykes AM, Fowdar JY, Silburn PA, Wood SA, Farrer MJ, Mellick GD. Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era. Genes. 12. PMID 33802862 DOI: 10.3390/genes12030430  0.386
2021 Lin CH, Farrer MJ, Wu RM. Reply: UQCRC1 variants in Parkinson's disease: a large cohort study in the Chinese mainland. Brain : a Journal of Neurology. PMID 33779722 DOI: 10.1093/brain/awab138  0.35
2021 Kuhlmann N, Wagner Valladolid M, Quesada-Ramírez L, Farrer MJ, Milnerwood AJ. Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons. Frontiers in Cellular Neuroscience. 15: 569031. PMID 33679324 DOI: 10.3389/fncel.2021.569031  0.628
2021 Bu M, Farrer MJ, Khoshbouei H. Dynamic control of the dopamine transporter in neurotransmission and homeostasis. Npj Parkinson's Disease. 7: 22. PMID 33674612 DOI: 10.1038/s41531-021-00161-2  0.339
2021 Follett J, Farrer MJ. LRRK2; a dynamic regulator of cellular trafficking. Brain Research. 1761: 147394. PMID 33662339 DOI: 10.1016/j.brainres.2021.147394  0.412
2020 Robert J, Weilinger NL, Cao LP, Cataldi S, Button EB, Stukas S, Martin EM, Seibler P, Gilmour M, Caffrey TM, Rowe EM, Fan J, MacVicar B, Farrer MJ, Wellington CL. An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases. Molecular Neurodegeneration. 15: 70. PMID 33213497 DOI: 10.1186/s13024-020-00418-z  0.583
2020 Lin CH, Tsai PI, Lin HY, Hattori N, Funayama M, Jeon B, Sato K, Abe K, Mukai Y, Takahashi Y, Li Y, Nishioka K, Yoshino H, Daida K, Chen ML, ... ... Farrer M, et al. Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy. Brain : a Journal of Neurology. PMID 33141179 DOI: 10.1093/brain/awaa279  0.427
2020 Lüth T, König IR, Grünewald A, Kasten M, Klein C, Hentati F, Farrer M, Trinh J. Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32875616 DOI: 10.1002/Mds.28238  0.42
2020 Brown EE, Blauwendraat C, Trinh J, Rizig M, Nalls MA, Leveille E, Ruskey JA, Jonvik H, Tan MMX, Bandres-Ciga S, Hassin-Baer S, Brockmann K, Infante J, Tolosa E, Ezquerra M, ... ... Farrer M, et al. Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease. Neurobiology of Aging. PMID 32873436 DOI: 10.1016/J.Neurobiolaging.2020.07.002  0.719
2020 Nybø CJ, Gustavsson EK, Farrer MJ, Aasly JO. Neuropathological findings in PINK1-associated Parkinson's disease. Parkinsonism & Related Disorders. 78: 105-108. PMID 32814227 DOI: 10.1016/j.parkreldis.2020.07.023  0.846
2020 MacIsaac S, Quevedo Melo T, Zhang Y, Volta M, Farrer MJ, Milnerwood AJ. Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous mutations and ameliorated by genetic knock-out. Brain Communications. 2: fcz052. PMID 32510053 DOI: 10.1093/braincomms/fcz052  0.682
2020 Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, ... ... Farrer MJ, et al. Variants in saposin D domain of prosaposin gene linked to Parkinson's disease. Brain : a Journal of Neurology. PMID 32201884 DOI: 10.1093/brain/awaa064  0.417
2020 Espay AJ, Kalia LV, Gan-Or Z, Williams-Gray CH, Bedard PL, Rowe SM, Morgante F, Fasano A, Stecher B, Kauffman MA, Farrer MJ, Coffey CS, Schwarzschild MA, Sherer T, Postuma RB, et al. Disease modification and biomarker development in Parkinson disease: Revision or reconstruction? Neurology. PMID 32102975 DOI: 10.1212/Wnl.0000000000009107  0.532
2019 Gustavsson EK, Follett J, Farrer MJ, Aasly JO. A Family with Primary Periodic Paralysis and a Mutation in MCM3AP, a gene implicated in mRNA Transport. Muscle & Nerve. PMID 31241196 DOI: 10.1002/mus.26622  0.799
2019 Follett J, Fox JD, Gustavsson EK, Kadgien C, Munsie LN, Cao LP, Tatarnikov I, Milnerwood AJ, Farrer MJ. DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of Sorting Nexin 1. Neuroscience Letters. PMID 31082451 DOI: 10.1016/J.Neulet.2019.04.043  0.792
2019 Farrer MJ, Follett J. Endosomal trafficking leads the way in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30812061 DOI: 10.1002/mds.27647  0.343
2018 Book A, Guella I, Candido T, Brice A, Hattori N, Jeon B, Farrer MJ. A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism. Frontiers in Neurology. 9: 1021. PMID 30619023 DOI: 10.3389/fneur.2018.01021  0.369
2018 Schildt A, Walker MD, Dinelle K, Miao Q, Schulzer M, O'Kusky J, Farrer MJ, Doudet DJ, Sossi V. Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons. Journal of Parkinson's Disease. PMID 30452424 DOI: 10.3233/JPD-181446  0.409
2018 Cataldi S, Follett J, Fox JD, Tatarnikov I, Kadgien C, Gustavsson EK, Khinda J, Milnerwood AJ, Farrer MJ. Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice. Npj Parkinson's Disease. 4: 27. PMID 30155515 DOI: 10.1038/S41531-018-0063-3  0.796
2018 Johansen KK, Torp SH, Farrer MJ, Gustavsson EK, Aasly JO. A Case of Parkinson's Disease with No Lewy Body Pathology due to a Homozygous Exon Deletion in . Case Reports in Neurological Medicine. 2018: 6838965. PMID 30050705 DOI: 10.1155/2018/6838965  0.365
2018 Johansen KK, Torp SH, Farrer MJ, Gustavsson EK, Aasly JO. A Case of Parkinson's Disease with No Lewy Body Pathology due to a Homozygous Exon Deletion in . Case Reports in Neurological Medicine. 2018: 6838965. PMID 30050705 DOI: 10.1155/2018/6838965  0.828
2018 Hou X, Fiesel FC, Truban D, Castanedes Casey M, Lin WL, Soto AI, Tacik P, Rousseau LG, Diehl NN, Heckman MG, Lorenzo-Betancor O, Ferrer I, Arbelo JM, Steele JC, Farrer MJ, et al. Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease. Autophagy. PMID 29947276 DOI: 10.1080/15548627.2018.1461294  0.379
2018 Bentley SR, Bortnick S, Guella I, Fowdar JY, Silburn PA, Wood SA, Farrer MJ, Mellick GD. Pipeline to gene discovery - Analysing familial Parkinsonism in the Queensland Parkinson's Project. Parkinsonism & Related Disorders. PMID 29329938 DOI: 10.1016/j.parkreldis.2017.12.033  0.347
2018 Gao Y, Wilson GR, Stephenson SEM, Bozaoglu K, Farrer MJ, Lockhart PJ. The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29315801 DOI: 10.1002/mds.27270  0.362
2018 Chiu M, Bai Y, Chan E, Huh L, Guella I, Farrer M, Connolly M, Liu L, Demos M, Wang Y. P.016 A novel de novo GABRA1 mutation linked to epileptic encephalopathy: pathophysiology and potential therapeutic options Canadian Journal of Neurological Sciences. 45. DOI: 10.1017/Cjn.2018.118  0.363
2017 Gustavsson EK, Trinh J, McKenzie M, Bortnick S, Petersen MS, Farrer MJ, Aasly JO. Genetic Identification in Early Onset Parkinsonism among Norwegian Patients. Movement Disorders Clinical Practice. 4: 499-508. PMID 30363439 DOI: 10.1002/mdc3.12501  0.83
2017 Kusters CDJ, Paul KC, Guella I, Bronstein JM, Sinsheimer JS, Farrer MJ, Ritz BR. Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease. Parkinsonism & Related Disorders. PMID 29191473 DOI: 10.1016/J.Parkreldis.2017.11.339  0.333
2017 Volta M, Beccano-Kelly DA, Paschall SA, Cataldi S, MacIsaac SE, Kuhlmann N, Kadgien CA, Tatarnikov I, Fox J, Khinda J, Mitchell E, Bergeron S, Melrose H, Farrer MJ, Milnerwood AJ. Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice. Elife. 6. PMID 28930069 DOI: 10.7554/Elife.28377  0.803
2017 Straniero L, Guella I, Cilia R, Parkkinen L, Rimoldi V, Young A, Asselta R, Soldà G, Sossi V, Stoessl AJ, Priori A, Nishioka K, Hattori N, Follett J, Rajput A, ... ... Farrer MJ, et al. DNAJC12 and dopa-responsive non-progressive Parkinsonism. Annals of Neurology. PMID 28892570 DOI: 10.1002/Ana.25048  0.343
2017 Yoshino H, Hirano M, Stoessl AJ, Imamichi Y, Ikeda A, Li Y, Funayama M, Yamada I, Nakamura Y, Sossi V, Farrer MJ, Nishioka K, Hattori N. Homozygous alpha-synuclein p.A53V in familial Parkinson's disease. Neurobiology of Aging. PMID 28666710 DOI: 10.1016/J.Neurobiolaging.2017.05.022  0.527
2017 Kim YE, Jeon B, Farrer MJ, Scott E, Guella I, Park SS, Kim JM, Park HY, Kim A, Son YD, Cho ZH. SCA2 family presenting as typical Parkinson's disease: 34 year follow up. Parkinsonism & Related Disorders. PMID 28462804 DOI: 10.1016/J.Parkreldis.2017.04.003  0.325
2017 Wile DJ, Agarwal PA, Schulzer M, Mak E, Dinelle K, Shahinfard E, Vafai N, Hasegawa K, Zhang J, McKenzie J, Neilson N, Strongosky A, Uitti RJ, Guttman M, Zabetian CP, ... ... Farrer M, et al. Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies. The Lancet. Neurology. PMID 28336296 DOI: 10.1016/S1474-4422(17)30056-X  0.455
2016 Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F. Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia. Bmc Neuroscience. 17: 77. PMID 27903237 DOI: 10.1186/s12868-016-0315-2  0.393
2016 Wang L, Heckman MG, Aasly JO, Annesi G, Bozi M, Chung SJ, Clarke C, Crosiers D, Eckstein G, Garraux G, Hadjigeorgiou GM, Hattori N, Jeon B, Kim YJ, Kubo M, ... ... Farrer MJ, et al. Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging. PMID 27814993 DOI: 10.1016/J.Neurobiolaging.2016.09.022  0.369
2016 Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, ... ... Farrer MJ, et al. Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism. Brain : a Journal of Neurology. PMID 27807026 DOI: 10.1093/Brain/Aww261  0.373
2016 Rajput AH, Ferguson LW, Robinson CA, Guella I, Farrer MJ, Rajput A. Conjugal parkinsonism is coincidental. Parkinsonism & Related Disorders. PMID 27743700 DOI: 10.1016/j.parkreldis.2016.10.004  0.352
2016 Trinh J, Gustavsson EK, Vilariño-Güell C, Bortnick S, Latourelle J, McKenzie MB, Tu CS, Nosova E, Khinda J, Milnerwood A, Lesage S, Brice A, Tazir M, Aasly JO, Parkkinen L, ... ... Farrer MJ, et al. DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study. The Lancet. Neurology. PMID 27692902 DOI: 10.1016/S1474-4422(16)30203-4  0.811
2016 Rajput AH, Ferguson LW, Robinson CA, Guella I, Farrer MJ, Rajput A. Conjugal parkinsonism - Clinical, pathology and genetic study. No evidence of person-to-person transmission. Parkinsonism & Related Disorders. PMID 27481034 DOI: 10.1016/j.parkreldis.2016.07.011  0.345
2016 Gustavsson EK, Trinh J, Guella I, Szu-Tu C, Khinda J, Lin CH, Wu RM, Stoessl J, Appel-Cresswell S, McKeown M, Rajput A, Rajput AH, Petersen MS, Jeon BS, Aasly JO, ... Farrer MJ, et al. DCTN1 p.K56R in progressive supranuclear palsy. Parkinsonism & Related Disorders. PMID 27132499 DOI: 10.1016/J.Parkreldis.2016.04.025  0.815
2016 Guella I, Evans DM, Szu-Tu C, Nosova E, Bortnick SF, Goldman JG, Dalrymple-Alford J, Geurtsen GJ, Litvan I, Ross OA, Middleton LT, Parkkinen L, Farrer MJ. α-synuclein genetic variability: A biomarker for dementia in Parkinson's disease. Annals of Neurology. PMID 27091628 DOI: 10.1002/Ana.24664  0.41
2016 Lin CH, Lin HI, Chen ML, Lai TT, Cao LP, Farrer MJ, Wu RM, Chien CT. Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity. Human Molecular Genetics. PMID 26931464 DOI: 10.1093/Hmg/Ddw068  0.319
2016 Carr J, Guella I, Szu-Tu C, Boolay S, Glanzmann B, Farrer MJ, Bardien S. Double homozygous mutations (R275W and M432V) in the ParkinGene associated with late-onset Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26860075 DOI: 10.1002/mds.26524  0.4
2016 Straniero L, Soldà G, Asselta R, Guella I, Pezzoli G, Farrer M, Goldwurm S, Duga S. Identification of novel PD genes by whole-exome sequencing in Italian families Parkinsonism & Related Disorders. 22. DOI: 10.1016/J.Parkreldis.2015.10.402  0.417
2015 Wile DJ, Dinelle K, Vafai N, McKenzie J, Tsui JK, Schaffer P, Ding YS, Farrer M, Sossi V, Stoessl AJ. A scan without evidence is not evidence of absence: Scans without evidence of dopaminergic deficit in a symptomatic leucine-rich repeat kinase 2 mutation carrier. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26685774 DOI: 10.1002/Mds.26450  0.46
2015 Volta M, Milnerwood AJ, Farrer MJ. Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease. The Lancet. Neurology. 14: 1054-64. PMID 26376970 DOI: 10.1016/S1474-4422(15)00186-6  0.735
2015 Wang L, Aasly JO, Annesi G, Bardien S, Bozi M, Brice A, Carr J, Chung SJ, Clarke C, Crosiers D, Deutschländer A, Eckstein G, Farrer MJ, Goldwurm S, Garraux G, et al. Large-scale assessment of polyglutamine repeat expansions in Parkinson disease. Neurology. PMID 26354989 DOI: 10.1212/Wnl.0000000000002016  0.353
2015 Volta M, Cataldi S, Beccano-Kelly D, Munsie L, Tatarnikov I, Chou P, Bergeron S, Mitchell E, Lim R, Khinda J, Lloret A, Bennett CF, Paradiso C, Morari M, Farrer MJ, et al. Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Parkinsonism & Related Disorders. 21: 1156-63. PMID 26282470 DOI: 10.1016/J.Parkreldis.2015.07.025  0.79
2015 Lorenzo-Betancor O, Ogaki K, Soto-Ortolaza AI, Labbe C, Walton RL, Strongosky AJ, van Gerpen JA, Uitti RJ, McLean PJ, Springer W, Siuda J, Opala G, Krygowska-Wajs A, Barcikowska M, Czyzewski K, ... ... Farrer MJ, et al. DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 22: 1323-5. PMID 26278106 DOI: 10.1111/Ene.12770  0.47
2015 Trinh J, Guella I, McKenzie M, Gustavsson EK, Szu-Tu C, Petersen MS, Rajput A, Rajput AH, McKeown M, Jeon BS, Aasly JO, Bardien S, Farrer MJ. Novel LRRK2 mutations in Parkinsonism. Parkinsonism & Related Disorders. PMID 26213354 DOI: 10.1016/J.Parkreldis.2015.07.011  0.824
2015 Yue M, Hinkle KM, Davies P, Trushina E, Fiesel FC, Christenson TA, Schroeder AS, Zhang L, Bowles E, Behrouz B, Lincoln SJ, Beevers JE, Milnerwood AJ, Kurti A, McLean PJ, ... ... Farrer MJ, et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiology of Disease. 78: 172-95. PMID 25836420 DOI: 10.1016/J.Nbd.2015.02.031  0.78
2015 Petersen MS, Bech S, Nosova E, Aasly J, Farrer MJ. Familial aggregation of Parkinson's disease in the Faroe Islands. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 538-44. PMID 25600277 DOI: 10.1002/mds.26132  0.38
2015 Guella I, Sherman HE, Appel-Cresswell S, Rajput A, Rajput AH, Farrer MJ. Parkinsonism in GTP cyclohydrolase 1 mutation carriers. Brain : a Journal of Neurology. 138: e349. PMID 25497597 DOI: 10.1093/brain/awu341  0.34
2015 Nabli F, Ben Sassi S, Amouri R, Duda JE, Farrer MJ, Hentati F. Motor phenotype of LRRK2-associated Parkinson's disease: a tunisian longitudinal study. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 253-8. PMID 25487881 DOI: 10.1002/mds.26097  0.372
2015 Gustavsson EK, Guella I, Trinh J, Szu-Tu C, Rajput A, Rajput AH, Steele JC, McKeown M, Jeon BS, Aasly JO, Farrer MJ. Genetic variability of the retromer cargo recognition complex in parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 580-4. PMID 25475142 DOI: 10.1002/Mds.26104  0.843
2015 Petersen MS, Guella I, Bech S, Gustavsson E, Farrer MJ. Parkinson's disease, genetic variability and the Faroe Islands. Parkinsonism & Related Disorders. 21: 75-8. PMID 25466404 DOI: 10.1016/j.parkreldis.2014.10.027  0.826
2015 Munsie LN, Milnerwood AJ, Seibler P, Beccano-Kelly DA, Tatarnikov I, Khinda J, Volta M, Kadgien C, Cao LP, Tapia L, Klein C, Farrer MJ. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N. Human Molecular Genetics. 24: 1691-703. PMID 25416282 DOI: 10.1093/Hmg/Ddu582  0.806
2015 Gustavsson EK, Trinh J, Guella I, Vilariño-Güell C, Appel-Cresswell S, Stoessl AJ, Tsui JK, McKeown M, Rajput A, Rajput AH, Aasly JO, Farrer MJ. DNAJC13 genetic variants in parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 273-8. PMID 25393719 DOI: 10.1002/Mds.26064  0.834
2015 Lee PC, Bordelon Y, Bronstein J, Sinsheimer JS, Farrer M, Ritz B. Head injury, α-synuclein genetic variability and Parkinson's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 22: 874-8. PMID 25370538 DOI: 10.1111/Ene.12585  0.423
2015 Beccano-Kelly DA, Volta M, Munsie LN, Paschall SA, Tatarnikov I, Co K, Chou P, Cao LP, Bergeron S, Mitchell E, Han H, Melrose HL, Tapia L, Raymond LA, Farrer MJ, et al. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Human Molecular Genetics. 24: 1336-49. PMID 25343991 DOI: 10.1093/Hmg/Ddu543  0.803
2015 Lorenzo-Betancor O, Ogaki K, Soto-Ortolaza AI, Labbe C, Walton RL, Strongosky AJ, van Gerpen JA, Uitti RJ, Mclean PJ, Springer W, Siuda J, Opala G, Krygowska-Wajs A, Barcikowska M, Czyzewski K, ... ... Farrer MJ, et al. DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients European Journal of Neurology. 22: 1323-1325. DOI: 10.1111/ene.12770  0.37
2015 Trinh J, Guella I, McKenzie M, Gustavsson EK, Szu-Tu C, Petersen MS, Rajput A, Rajput AH, McKeown M, Jeon BS, Aasly JO, Bardien S, Farrer MJ. Novel LRRK2 mutations in Parkinsonism Parkinsonism and Related Disorders. DOI: 10.1016/j.parkreldis.2015.07.011  0.351
2014 Heckman MG, Schottlaender L, Soto-Ortolaza AI, Diehl NN, Rayaprolu S, Ogaki K, Fujioka S, Murray ME, Cheshire WP, Uitti RJ, Wszolek ZK, Farrer MJ, Sailer A, Singleton AB, Chinnery PF, et al. LRRK2 exonic variants and risk of multiple system atrophy. Neurology. 83: 2256-61. PMID 25378673 DOI: 10.1212/Wnl.0000000000001078  0.4
2014 Trinh J, Guella I, Farrer MJ. Disease penetrance of late-onset parkinsonism: a meta-analysis. Jama Neurology. 71: 1535-9. PMID 25330418 DOI: 10.1001/jamaneurol.2014.1909  0.408
2014 Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P, Cao LP, Han H, Tapia L, Farrer MJ, Milnerwood AJ. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Frontiers in Cellular Neuroscience. 8: 301. PMID 25309331 DOI: 10.3389/Fncel.2014.00301  0.797
2014 Trinh J, Gustavsson EK, Guella I, Vilariño-Güell C, Evans D, Encarnacion M, Sherman H, Hentati F, Farrer MJ. The role of SNCA and MAPT in Parkinson disease and LRRK2 parkinsonism in the Tunisian Arab-Berber population. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 21: e91-2. PMID 25303626 DOI: 10.1111/ene.12489  0.348
2014 Lin MK, Farrer MJ. Genetics and genomics of Parkinson's disease. Genome Medicine. 6: 48. PMID 25061481 DOI: 10.1186/gm566  0.424
2014 Hentati F, Trinh J, Thompson C, Nosova E, Farrer MJ, Aasly JO. LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance. Neurology. 83: 568-9. PMID 25008396 DOI: 10.1212/WNL.0000000000000675  0.362
2014 Walker MD, Volta M, Cataldi S, Dinelle K, Beccano-Kelly D, Munsie L, Kornelsen R, Mah C, Chou P, Co K, Khinda J, Mroczek M, Bergeron S, Yu K, Cao LP, ... ... Farrer MJ, et al. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. Journal of Parkinson's Disease. 4: 483-98. PMID 25000966 DOI: 10.3233/Jpd-140344  0.825
2014 Nishioka K, Funayama M, Vilariño-Güell C, Ogaki K, Li Y, Sasaki R, Kokubo Y, Kuzuhara S, Kachergus JM, Cobb SA, Takahashi H, Mizuno Y, Farrer MJ, Ross OA, Hattori N. EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population. Parkinsonism & Related Disorders. 20: 659-61. PMID 24704100 DOI: 10.1016/J.Parkreldis.2014.03.004  0.403
2014 Araki E, Tsuboi Y, Daechsel J, Milnerwood A, Vilarino-Guell C, Fujii N, Mishima T, Oka T, Hara H, Fukae J, Farrer MJ. A novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1201-4. PMID 24676999 DOI: 10.1002/Mds.25833  0.727
2014 Markopoulou K, Biernacka JM, Armasu SM, Anderson KJ, Ahlskog JE, Chase BA, Chung SJ, Cunningham JM, Farrer M, Frigerio R, Maraganore DM. Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease? Parkinsonism & Related Disorders. 20: 584-9; discussion 58. PMID 24656894 DOI: 10.1016/J.Parkreldis.2014.02.021  0.451
2014 Trinh J, Amouri R, Duda JE, Morley JF, Read M, Donald A, Vilariño-Güell C, Thompson C, Szu Tu C, Gustavsson EK, Ben Sassi S, Hentati E, Zouari M, Farhat E, Nabli F, ... ... Farrer MJ, et al. Comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism. Neurobiology of Aging. 35: 1125-31. PMID 24355527 DOI: 10.1016/j.neurobiolaging.2013.11.015  0.838
2014 Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M, Munsie LN, Tapia L, Gustavsson EK, Chou P, Tatarnikov I, Evans DM, Pishotta FT, ... ... Farrer MJ, et al. DNAJC13 mutations in Parkinson disease. Human Molecular Genetics. 23: 1794-801. PMID 24218364 DOI: 10.1093/Hmg/Ddt570  0.835
2014 Heckman MG, Elbaz A, Soto-Ortolaza AI, Serie DJ, Aasly JO, Annesi G, Auburger G, Bacon JA, Boczarska-Jedynak M, Bozi M, Brighina L, Chartier-Harlin MC, Dardiotis E, Destée A, Ferrarese C, ... ... Farrer MJ, et al. Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants. Neurobiology of Aging. 35: 266.e5-14. PMID 23962496 DOI: 10.1016/J.Neurobiolaging.2013.07.013  0.607
2014 Heckman MG, Schottlaender L, Soto-Ortolaza AI, Diehl NN, Rayaprolu S, Ogaki K, Fujioka S, Murray ME, Cheshire WP, Uitti RJ, Wszolek ZK, Farrer MJ, Sailer A, Singleton AB, Chinnery PF, et al. LRRK2 exonic variants and risk of multiple system atrophy Neurology. 83: 2256-2261.  0.373
2013 Heckman MG, Soto-Ortolaza AI, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, ... ... Farrer MJ, et al. Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1740-4. PMID 23913756 DOI: 10.1002/Mds.25600  0.664
2013 Trinh J, Farrer M. Advances in the genetics of Parkinson disease. Nature Reviews. Neurology. 9: 445-54. PMID 23857047 DOI: 10.1038/Nrneurol.2013.132  0.502
2013 Appel-Cresswell S, Vilarino-Guell C, Encarnacion M, Sherman H, Yu I, Shah B, Weir D, Thompson C, Szu-Tu C, Trinh J, Aasly JO, Rajput A, Rajput AH, Jon Stoessl A, Farrer MJ. Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 811-3. PMID 23457019 DOI: 10.1002/Mds.25421  0.398
2013 Trinh J, Vilariño-Güell C, Donald A, Shah B, Yu I, Szu-Tu C, Aasly JO, Wu RM, Hentati F, Rajput AH, Rajput A, Farrer MJ. STX6 rs1411478 is not associated with increased risk of Parkinson's disease. Parkinsonism & Related Disorders. 19: 563-5. PMID 23415606 DOI: 10.1016/J.Parkreldis.2013.01.019  0.428
2013 Singleton AB, Farrer MJ, Bonifati V. The genetics of Parkinson's disease: progress and therapeutic implications. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 14-23. PMID 23389780 DOI: 10.1002/mds.25249  0.585
2013 Fujioka S, Sundal C, Strongosky AJ, Castanedes MC, Rademakers R, Ross OA, Vilariño-Güell C, Farrer MJ, Wszolek ZK, Dickson DW. Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia. Acta Neuropathologica. 125: 425-38. PMID 23124435 DOI: 10.1007/S00401-012-1059-4  0.307
2013 Sossi V, Agarwal P, Mckenzie J, Dinelle K, Schulzer M, Aasly J, Wszolek Z, Farrer M, Stoessl AJ. Insights into LRRK2-Mutation Related PD from PET Imaging Studies Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 123-124. DOI: 10.1016/B978-0-12-800044-1.00106-9  0.301
2012 Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, et al. A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. Journal of Medical Genetics. 49: 721-6. PMID 23125461 DOI: 10.1136/Jmedgenet-2012-101155  0.5
2012 Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, et al. Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology. 79: 659-67. PMID 22786590 DOI: 10.1212/Wnl.0B013E318264E353  0.393
2012 Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ, Bowles EE, Beevers JE, Dugger B, Winner B, Prots I, Kent CB, Nishioka K, Lin WL, Dickson DW, Janus CJ, ... Farrer MJ, et al. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Molecular Neurodegeneration. 7: 25. PMID 22647713 DOI: 10.1186/1750-1326-7-25  0.766
2012 Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, ... ... Farrer MJ, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. Plos Genetics. 8: e1002548. PMID 22438815 DOI: 10.1371/Journal.Pgen.1002548  0.642
2012 Gaweda-Walerych K, Safranow K, Jasinska-Myga B, Bialecka M, Klodowska-Duda G, Rudzinska M, Czyzewski K, Cobb SA, Slawek J, Styczynska M, Opala G, Drozdzik M, Nishioka K, Farrer MJ, Ross OA, et al. PARK2 variability in Polish Parkinson's disease patients--interaction with mitochondrial haplogroups. Parkinsonism & Related Disorders. 18: 520-4. PMID 22361577 DOI: 10.1016/j.parkreldis.2012.01.021  0.303
2012 Puschmann A, Englund E, Ross OA, Vilariño-Güell C, Lincoln SJ, Kachergus JM, Cobb SA, Törnqvist AL, Rehncrona S, Widner H, Wszolek ZK, Farrer MJ, Nilsson C. First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation. Parkinsonism & Related Disorders. 18: 332-8. PMID 22154298 DOI: 10.1016/j.parkreldis.2011.11.019  0.415
2012 Ben Sassi S, Nabli F, Hentati E, Nahdi H, Trabelsi M, Ben Ayed H, Amouri R, Duda JE, Farrer MJ, Hentati F. Cognitive dysfunction in Tunisian LRRK2 associated Parkinson's disease. Parkinsonism & Related Disorders. 18: 243-6. PMID 22056842 DOI: 10.1016/J.Parkreldis.2011.10.009  0.33
2011 Ross OA, Conneely KN, Wang T, Vilarino-Guell C, Soto-Ortolaza AI, Rajput A, Wszolek ZK, Uitti RJ, Louis ED, Clark LN, Farrer MJ, Testa CM. Genetic variants of α-synuclein are not associated with essential tremor. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2552-6. PMID 22025277 DOI: 10.1002/Mds.23909  0.314
2011 Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, ... ... Farrer MJ, et al. Translation initiator EIF4G1 mutations in familial Parkinson disease. American Journal of Human Genetics. 89: 398-406. PMID 21907011 DOI: 10.1016/J.Ajhg.2011.08.009  0.806
2011 Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, ... ... Farrer MJ, et al. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. The Lancet. Neurology. 10: 898-908. PMID 21885347 DOI: 10.1016/S1474-4422(11)70175-2  0.689
2011 Angeles DC, Gan BH, Onstead L, Zhao Y, Lim KL, Dachsel J, Melrose H, Farrer M, Wszolek ZK, Dickson DW, Tan EK. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. Human Mutation. 32: 1390-7. PMID 21850687 DOI: 10.1002/Humu.21582  0.471
2011 Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Van Broeckhoven C, Chartier-Harlin MC, Destée A, Djarmati A, Elbaz A, Farrer M, et al. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease. Neurobiology of Aging. 32: 2108.e1-5. PMID 21782285 DOI: 10.1016/J.Neurobiolaging.2011.05.024  0.697
2011 Vilariño-Güell C, Wider C, Ross OA, Dachsel JC, Kachergus JM, Lincoln SJ, Soto-Ortolaza AI, Cobb SA, Wilhoite GJ, Bacon JA, Behrouz B, Melrose HL, Hentati E, Puschmann A, Evans DM, ... ... Farrer MJ, et al. VPS35 mutations in Parkinson disease. American Journal of Human Genetics. 89: 162-7. PMID 21763482 DOI: 10.1016/j.ajhg.2011.06.001  0.81
2011 Dachsel JC, Wider C, Vilariño-Güell C, Aasly JO, Rajput A, Rajput AH, Lynch T, Craig D, Krygowska-Wajs A, Jasinska-Myga B, Opala G, Barcikowska M, Czyzewski K, Wu RM, Heckman MG, ... ... Farrer MJ, et al. Death-associated protein kinase 1 variation and Parkinson's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 18: 1090-3. PMID 21749573 DOI: 10.1111/j.1468-1331.2010.03255.x  0.362
2011 Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, ... ... Farrer MJ, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 43: 699-705. PMID 21685912 DOI: 10.1038/Ng.859  0.692
2011 Johansen KK, White LR, Farrer MJ, Aasly JO. Subclinical signs in LRRK2 mutation carriers. Parkinsonism & Related Disorders. 17: 528-32. PMID 21641848 DOI: 10.1016/j.parkreldis.2011.04.014  0.364
2011 Mata IF, Wilhoite GJ, Yearout D, Bacon JA, Cornejo-Olivas M, Mazzetti P, Marca V, Ortega O, Acosta O, Cosentino C, Torres L, Medina AC, Perez-Pastene C, Díaz-Grez F, Vilariño-Güell C, ... ... Farrer MJ, et al. Lrrk2 p.Q1111H substitution and Parkinson's disease in Latin America. Parkinsonism & Related Disorders. 17: 629-31. PMID 21632271 DOI: 10.1016/J.Parkreldis.2011.05.003  0.363
2011 Puschmann A, Pfeiffer RF, Stoessl AJ, Kuriakose R, Lash JL, Searcy JA, Strongosky AJ, Vilariño-Güell C, Farrer MJ, Ross OA, Dickson DW, Wszolek ZK. A family with Parkinsonism, essential tremor, restless legs syndrome, and depression. Neurology. 76: 1623-30. PMID 21555728 DOI: 10.1212/Wnl.0B013E318219Fb42  0.354
2011 Chung SJ, Armasu SM, Biernacka JM, Lesnick TG, Rider DN, Lincoln SJ, Ortolaza AI, Farrer MJ, Cunningham JM, Rocca WA, Maraganore DM. Common variants in PARK loci and related genes and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 280-8. PMID 21412835 DOI: 10.1002/mds.23376  0.371
2011 Elbaz A, Ross OA, Ioannidis JP, Soto-Ortolaza AI, Moisan F, Aasly J, Annesi G, Bozi M, Brighina L, Chartier-Harlin MC, Destée A, Ferrarese C, Ferraris A, Gibson JM, Gispert S, ... ... Farrer MJ, et al. Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. Annals of Neurology. 69: 778-92. PMID 21391235 DOI: 10.1002/Ana.22321  0.598
2011 Shi G, Lee JR, Grimes DA, Racacho L, Ye D, Yang H, Ross OA, Farrer M, McQuibban GA, Bulman DE. Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease. Human Molecular Genetics. 20: 1966-74. PMID 21355049 DOI: 10.1093/Hmg/Ddr077  0.454
2011 Vilariño-Güell C, Soto-Ortolaza AI, Rajput A, Mash DC, Papapetropoulos S, Pahwa R, Lyons KE, Uitti RJ, Wszolek ZK, Dickson DW, Farrer MJ, Ross OA. MAPT H1 haplotype is a risk factor for essential tremor and multiple system atrophy. Neurology. 76: 670-2. PMID 21321341 DOI: 10.1212/Wnl.0B013E31820C30C1  0.354
2011 Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, Braithwaite AT, Ogholikhan S, Aigner R, Winkler J, Farrer MJ, Gage FH. Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiology of Disease. 41: 706-16. PMID 21168496 DOI: 10.1016/J.Nbd.2010.12.008  0.41
2011 Nishioka K, Ross OA, Vilariño-Güell C, Cobb SA, Kachergus JM, Mann DM, Snowden J, Richardson AM, Neary D, Robinson CA, Rajput A, Papapetropoulos S, Mash DC, Pahwa R, Lyons KE, ... ... Farrer MJ, et al. Glucocerebrosidase mutations in diffuse Lewy body disease. Parkinsonism & Related Disorders. 17: 55-7. PMID 20971030 DOI: 10.1016/J.Parkreldis.2010.09.009  0.345
2011 Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson-related genetics in patients treated with deep brain stimulation. Acta Neurologica Scandinavica. 123: 201-6. PMID 20545633 DOI: 10.1111/j.1600-0404.2010.01387.x  0.352
2011 Krüger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, et al. A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiology of Aging. 32: 548.e9-18. PMID 20036034 DOI: 10.1016/J.Neurobiolaging.2009.11.021  0.465
2010 Nishioka K, Vilariño-Güell C, Cobb SA, Kachergus JM, Ross OA, Hentati E, Hentati F, Farrer MJ. Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson's disease. Parkinsonism & Related Disorders. 16: 686-7. PMID 20971673 DOI: 10.1016/J.Parkreldis.2010.09.007  0.415
2010 Sossi V, de la Fuente-Fernández R, Nandhagopal R, Schulzer M, McKenzie J, Ruth TJ, Aasly JO, Farrer MJ, Wszolek ZK, Stoessl JA. Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 2717-23. PMID 20939082 DOI: 10.1002/mds.23356  0.361
2010 Behrouz B, Vilariño-Güell C, Heckman MG, Soto-Ortolaza AI, Aasly JO, Sando S, Lynch T, Craig D, Uitti RJ, Wszolek ZK, Ross OA, Farrer MJ. Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease. Neuroscience Letters. 486: 228-30. PMID 20887776 DOI: 10.1016/J.Neulet.2010.09.059  0.779
2010 Dächsel JC, Behrouz B, Yue M, Beevers JE, Melrose HL, Farrer MJ. A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism & Related Disorders. 16: 650-5. PMID 20850369 DOI: 10.1016/J.Parkreldis.2010.08.018  0.742
2010 Jasinska-Myga B, Kachergus J, Vilariño-Güell C, Wider C, Soto-Ortolaza AI, Kefi M, Middleton LT, Ishihara-Paul L, Gibson RA, Amouri R, Yahmed SB, Sassi SB, Zouari M, El Euch G, Ross OA, ... ... Farrer MJ, et al. Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 2052-8. PMID 20721913 DOI: 10.1002/Mds.23283  0.426
2010 Aasly JO, Vilariño-Güell C, Dachsel JC, Webber PJ, West AB, Haugarvoll K, Johansen KK, Toft M, Nutt JG, Payami H, Kachergus JM, Lincoln SJ, Felic A, Wider C, Soto-Ortolaza AI, ... ... Farrer MJ, et al. Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 2156-63. PMID 20669305 DOI: 10.1002/mds.23265  0.409
2010 Ross OA, Wilhoite GJ, Bacon JA, Soto-Ortolaza A, Kachergus J, Cobb SA, Puschmann A, Vilariño-Güell C, Farrer MJ, Graff-Radford N, Meschia JF, Wszolek ZK. LRRK2 variation and Parkinson's disease in African Americans. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 1973-6. PMID 20669299 DOI: 10.1002/mds.23163  0.389
2010 Gatto NM, Rhodes SL, Manthripragada AD, Bronstein J, Cockburn M, Farrer M, Ritz B. α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease. Neuroepidemiology. 35: 191-5. PMID 20664293 DOI: 10.1159/000315157  0.412
2010 Melrose HL, Dächsel JC, Behrouz B, Lincoln SJ, Yue M, Hinkle KM, Kent CB, Korvatska E, Taylor JP, Witten L, Liang YQ, Beevers JE, Boules M, Dugger BN, Serna VA, ... ... Farrer MJ, et al. Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiology of Disease. 40: 503-17. PMID 20659558 DOI: 10.1016/J.Nbd.2010.07.010  0.765
2010 Johansen KK, Hasselberg K, White LR, Farrer MJ, Aasly JO. Genealogical studies in LRRK2-associated Parkinson's disease in central Norway. Parkinsonism & Related Disorders. 16: 527-30. PMID 20621541 DOI: 10.1016/j.parkreldis.2010.05.005  0.403
2010 Ross OA, Farrer MJ. Parkinson disease: Parkinson disease-moving beyond association. Nature Reviews. Neurology. 6: 305-7. PMID 20531431 DOI: 10.1038/nrneurol.2010.69  0.353
2010 Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G. Missing pieces in the Parkinson's disease puzzle. Nature Medicine. 16: 653-61. PMID 20495568 DOI: 10.1038/Nm.2165  0.405
2010 Lee H, Melrose HL, Yue M, Pare JF, Farrer MJ, Smith Y. Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeys. Experimental Neurology. 224: 438-47. PMID 20483355 DOI: 10.1016/j.expneurol.2010.05.004  0.317
2010 Dächsel JC, Farrer MJ. LRRK2 and Parkinson disease. Archives of Neurology. 67: 542-7. PMID 20457952 DOI: 10.1001/archneurol.2010.79  0.373
2010 Ross OA, Vilariño-Güell C, Wszolek ZK, Farrer MJ, Dickson DW. Reply to: SNCA variants are associated with increased risk of multiple system atrophy. Annals of Neurology. 67: 414-5. PMID 20373361 DOI: 10.1002/Ana.21786  0.339
2010 Vilariño-Güell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, Soto-Ortolaza AI, Behrouz B, Heckman MG, Diehl NN, Testa CM, Wszolek ZK, Uitti RJ, Jankovic J, Louis ED, ... ... Farrer MJ, et al. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics. 11: 401-8. PMID 20369371 DOI: 10.1007/S10048-010-0241-X  0.776
2010 Taylor A, Wang D, Patel K, Whittall R, Wood G, Farrer M, Neely RD, Fairgrieve S, Nair D, Barbir M, Jones JL, Egan S, Everdale R, Lolin Y, Hughes E, et al. Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project. Clinical Genetics. 77: 572-80. PMID 20236128 DOI: 10.1111/J.1399-0004.2009.01356.X  0.373
2010 Dachsel JC, Nishioka K, Vilariño-Güell C, Lincoln SJ, Soto-Ortolaza AI, Kachergus J, Hinkle KM, Heckman MG, Jasinska-Myga B, Taylor JP, Dickson DW, Gibson RA, Hentati F, Ross OA, Farrer MJ. Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease. Mechanisms of Ageing and Development. 131: 210-4. PMID 20144646 DOI: 10.1016/J.Mad.2010.01.009  0.431
2010 Nishioka K, Vilariño-Güell C, Cobb SA, Kachergus JM, Ross OA, Wider C, Gibson RA, Hentati F, Farrer MJ. Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa. Neuroscience Letters. 477: 57-60. PMID 19945510 DOI: 10.1016/J.Neulet.2009.11.066  0.396
2010 Keeling BH, Vilariño-Güell C, Soto-Ortolaza AI, Ross OA, Uitti RJ, Rajput A, Wszolek ZK, Farrer MJ. Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor. Parkinsonism & Related Disorders. 16: 112-4. PMID 19773194 DOI: 10.1016/j.parkreldis.2009.08.011  0.356
2010 Wider C, Dachsel JC, Farrer MJ, Dickson DW, Tsuboi Y, Wszolek ZK. Elucidating the genetics and pathology of Perry syndrome. Journal of the Neurological Sciences. 289: 149-54. PMID 19732908 DOI: 10.1016/J.Jns.2009.08.044  0.316
2010 Nishioka K, Kefi M, Jasinska-Myga B, Wider C, Vilariño-Güell C, Ross OA, Heckman MG, Middleton LT, Ishihara-Paul L, Gibson RA, Amouri R, Ben Yahmed S, Ben Sassi S, Zouari M, El Euch G, ... Farrer MJ, et al. A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 81: 391-5. PMID 19726410 DOI: 10.1136/Jnnp.2009.185231  0.446
2010 Vilariño-Güell C, Ross OA, Wider C, Jasinska-Myga B, Cobb SA, Soto-Ortolaza AI, Kachergus JM, Keeling BH, Dachsel JC, Melrose HL, Behrouz B, Wszolek ZK, Uitti RJ, Aasly JO, Rajput A, ... Farrer MJ, et al. LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. Parkinsonism & Related Disorders. 16: 109-11. PMID 19720553 DOI: 10.1016/J.Parkreldis.2009.08.006  0.775
2010 Soto-Ortolaza AI, Behrouz B, Wider C, Vilariño-Güell C, Heckman MG, Aasly JO, Mark Gibson J, Lynch T, Jasinska-Myga B, Krygowska-Wajs A, Opala G, Barcikowska M, Czyzewski K, Uitti RJ, Wszolek ZK, ... Farrer MJ, et al. Calbindin-1 association and Parkinson's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 17: 208-11. PMID 19674066 DOI: 10.1111/J.1468-1331.2009.02769.X  0.777
2010 Puschmann A, Lindskov S, Marktorp C, Nilsson C, Nilsson K, Reimer J, Westen Dv, Persson E, Widner H, Lincoln S, Cobb S, Ross O, Vilarino-Guell C, Farrer M, Wszolek ZK. Hereditary Parkinson's Disease of Unknown Genetic Cause in Two Families from Southern Sweden Movement Disorders. 25. DOI: 10.1002/Mds.23126  0.466
2009 Rajput A, Vilariño-Güell C, Rajput ML, Ross OA, Soto-Ortolaza AI, Lincoln SJ, Cobb SA, Heckman MG, Farrer MJ, Rajput A. Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 2411-4. PMID 19890971 DOI: 10.1002/mds.22795  0.452
2009 Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, Clark LN, Condroyer C, De Marco EV, Dürr A, ... ... Farrer MJ, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. The New England Journal of Medicine. 361: 1651-61. PMID 19846850 DOI: 10.1056/Nejmoa0901281  0.592
2009 Cobb SA, Wider C, Ross OA, Mata IF, Adler CH, Rajput A, Rajput AH, Wu RM, Hauser R, Josephs KA, Carr J, Gwinn K, Heckman MG, Aasly JO, Lynch T, ... ... Farrer MJ, et al. GCH1 in early-onset Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 2070-5. PMID 19735094 DOI: 10.1002/Mds.22729  0.344
2009 Puschmann A, Ross OA, Vilariño-Güell C, Lincoln SJ, Kachergus JM, Cobb SA, Lindquist SG, Nielsen JE, Wszolek ZK, Farrer M, Widner H, van Westen D, Hägerström D, Markopoulou K, Chase BA, et al. A Swedish family with de novo alpha-synuclein A53T mutation: evidence for early cortical dysfunction. Parkinsonism & Related Disorders. 15: 627-32. PMID 19632874 DOI: 10.1016/J.Parkreldis.2009.06.007  0.492
2009 Ritz BR, Manthripragada AD, Costello S, Lincoln SJ, Farrer MJ, Cockburn M, Bronstein J. Dopamine transporter genetic variants and pesticides in Parkinson's disease. Environmental Health Perspectives. 117: 964-9. PMID 19590691 DOI: 10.1289/Ehp.0800277  0.32
2009 Nishioka K, Ross OA, Ishii K, Kachergus JM, Ishiwata K, Kitagawa M, Kono S, Obi T, Mizoguchi K, Inoue Y, Imai H, Takanashi M, Mizuno Y, Farrer MJ, Hattori N. Expanding the clinical phenotype of SNCA duplication carriers. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 1811-9. PMID 19562770 DOI: 10.1002/mds.22682  0.371
2009 Keeling BH, Vilariño-Güell C, Ross OA, Wszolek ZK, Uitti RJ, Farrer MJ. DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease. Neuroscience Letters. 461: 74-5. PMID 19524641 DOI: 10.1016/j.neulet.2009.05.084  0.362
2009 Vilariño-Güell C, Wider C, Soto-Ortolaza AI, Cobb SA, Kachergus JM, Keeling BH, Dachsel JC, Hulihan MM, Dickson DW, Wszolek ZK, Uitti RJ, Graff-Radford NR, Boeve BF, Josephs KA, Miller B, ... ... Farrer MJ, et al. Characterization of DCTN1 genetic variability in neurodegeneration. Neurology. 72: 2024-8. PMID 19506225 DOI: 10.1212/Wnl.0B013E3181A92C4C  0.69
2009 Wider C, Lincoln SJ, Heckman MG, Diehl NN, Stone JT, Haugarvoll K, Aasly JO, Gibson JM, Lynch T, Rajput A, Rajput ML, Uitti RJ, Wszolek ZK, Farrer MJ, Ross OA. Phactr2 and Parkinson's disease. Neuroscience Letters. 453: 9-11. PMID 19429005 DOI: 10.1016/J.Neulet.2009.02.009  0.315
2009 Taylor JM, Wu RM, Farrer MJ, Delatycki MB, Lockhart PJ. Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease. Parkinsonism & Related Disorders. 15: 417-21. PMID 19196541 DOI: 10.1016/j.parkreldis.2008.11.009  0.41
2009 Farrer MJ, Hulihan MM, Kachergus JM, Dächsel JC, Stoessl AJ, Grantier LL, Calne S, Calne DB, Lechevalier B, Chapon F, Tsuboi Y, Yamada T, Gutmann L, Elibol B, Bhatia KP, et al. DCTN1 mutations in Perry syndrome. Nature Genetics. 41: 163-5. PMID 19136952 DOI: 10.1038/Ng.293  0.33
2009 Vilariño-Güell C, Ross OA, Soto AI, Farrer MJ, Haugarvoll K, Aasly JO, Uitti RJ, Wszolek ZK. Reported mutations in GIGYF2 are not a common cause of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 619-20. PMID 19133664 DOI: 10.1002/mds.22451  0.386
2009 Wider C, Dachsel JC, Soto AI, Heckman MG, Diehl NN, Yue M, Lincoln S, Aasly JO, Haugarvoll K, Trojanowski JQ, Papapetropoulos S, Mash D, Rajput A, Rajput AH, Gibson JM, ... ... Farrer MJ, et al. FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 455-9. PMID 19133659 DOI: 10.1002/Mds.22442  0.32
2009 Vilariño-Güell C, Soto AI, Lincoln SJ, Ben Yahmed S, Kefi M, Heckman MG, Hulihan MM, Chai H, Diehl NN, Amouri R, Rajput A, Mash DC, Dickson DW, Middleton LT, Gibson RA, ... ... Farrer MJ, et al. ATP13A2 variability in Parkinson disease. Human Mutation. 30: 406-10. PMID 19085912 DOI: 10.1002/Humu.20877  0.411
2009 Golub Y, Berg D, Calne DB, Pfeiffer RF, Uitti RJ, Stoessl AJ, Wszolek ZK, Farrer MJ, Mueller JC, Gasser T, Fuchs J. Genetic factors influencing age at onset in LRRK2-linked Parkinson disease. Parkinsonism & Related Disorders. 15: 539-41. PMID 19041274 DOI: 10.1016/J.Parkreldis.2008.10.008  0.442
2009 Lee MJ, Mata IF, Lin CH, Tzen KY, Lincoln SJ, Bounds R, Lockhart PJ, Hulihan MM, Farrer MJ, Wu RM. Genotype-phenotype correlates in Taiwanese patients with early-onset recessive Parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. 24: 104-8. PMID 19006224 DOI: 10.1002/mds.22093  0.317
2009 Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ. Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism. Parkinsonism & Related Disorders. 15: 466-7. PMID 18952485 DOI: 10.1016/J.Parkreldis.2008.09.001  0.35
2009 Puschmann A, Wszolek ZK, Farrer M, Gustafson L, Widner H, Nilsson C. Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus? Parkinsonism & Related Disorders. 15: 390-2. PMID 18824390 DOI: 10.1016/J.Parkreldis.2008.08.002  0.483
2009 Gatto N, Cockburn M, Bronstein J, Farrer M, Ritz B. α-Synuclein Repeat Polymorphisms and Pesticide Exposure in Parkinsonʼs Disease Epidemiology. 20: S124. DOI: 10.1097/01.Ede.0000362429.51721.26  0.305
2009 Chartier-Harlin M, Dachsel J, Hulihan M, Kachergus J, Lepretre F, Le Rhun E, Mutez E, Lincoln S, Ross O, Vilariño-Güell C, Yanagiya A, Sonenberg N, Lockhart P, Wszolek Z, Aasly J, ... ... Farrer M, et al. P2.206 EIF4G1 mutations in familial parkinsonism Parkinsonism & Related Disorders. 15: S145-S146. DOI: 10.1016/S1353-8020(09)70557-7  0.646
2009 Johansen K, Jørgensen J, Farrer M, Aasly J. P2.039 High frequency of genetically-determined Parkinson's disease in patients referred to deep brain stimulation Parkinsonism & Related Disorders. 15. DOI: 10.1016/S1353-8020(09)70390-6  0.386
2009 Vilariño-Güell C, Ross OA, Farrer MJ. Reply: GIGYF2 variants are not associated with Parkinson's disease in Italy Movement Disorders. 24: 1868-1869. DOI: 10.1002/mds.22614  0.344
2008 Nandhagopal R, Mak E, Schulzer M, McKenzie J, McCormick S, Sossi V, Ruth TJ, Strongosky A, Farrer MJ, Wszolek ZK, Stoessl AJ. Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study. Neurology. 71: 1790-5. PMID 19029519 DOI: 10.1212/01.wnl.0000335973.66333.58  0.363
2008 Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, ... ... Farrer MJ, et al. In vivo silencing of alpha-synuclein using naked siRNA. Molecular Neurodegeneration. 3: 19. PMID 18976489 DOI: 10.1186/1750-1326-3-19  0.387
2008 Ross OA, Soto AI, Vilariño-Güell C, Heckman MG, Diehl NN, Hulihan MM, Aasly JO, Sando S, Gibson JM, Lynch T, Krygowska-Wajs A, Opala G, Barcikowska M, Czyzewski K, Uitti RJ, ... ... Farrer MJ, et al. Genetic variation of Omi/HtrA2 and Parkinson's disease. Parkinsonism & Related Disorders. 14: 539-43. PMID 18790661 DOI: 10.1016/J.Parkreldis.2008.08.003  0.413
2008 Ishihara-Paul L, Hulihan MM, Kachergus J, Upmanyu R, Warren L, Amouri R, Elango R, Prinjha RK, Soto A, Kefi M, Zouari M, Sassi SB, Yahmed SB, El Euch-Fayeche G, Matthews PM, ... ... Farrer MJ, et al. PINK1 mutations and parkinsonism. Neurology. 71: 896-902. PMID 18685134 DOI: 10.1212/01.wnl.0000323812.40708.1f  0.451
2008 Djaldetti R, Hassin-Baer S, Farrer MJ, Vilariño-Güell C, Ross OA, Kolianov V, Yust-Katz S, Treves TA, Barhum Y, Hulihan M, Melamed E. Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel. Journal of Neural Transmission (Vienna, Austria : 1996). 115: 1279-84. PMID 18665323 DOI: 10.1007/s00702-008-0074-z  0.369
2008 Farrer M. The genetics and molecular biology of alpha-synuclein. Handbook of Clinical Neurology. 89: 313-9. PMID 18631756 DOI: 10.1016/S0072-9752(07)01230-4  0.482
2008 Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CH, Larvor L, Chartier-Harlin MC, Nilsson C, Langston JW, ... ... Farrer MJ, et al. Genomic investigation of alpha-synuclein multiplication and parkinsonism. Annals of Neurology. 63: 743-50. PMID 18571778 DOI: 10.1002/ana.21380  0.613
2008 Hulihan MM, Ishihara-Paul L, Kachergus J, Warren L, Amouri R, Elango R, Prinjha RK, Upmanyu R, Kefi M, Zouari M, Sassi SB, Yahmed SB, El Euch-Fayeche G, Matthews PM, Middleton LT, ... ... Farrer MJ, et al. LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study. The Lancet. Neurology. 7: 591-4. PMID 18539535 DOI: 10.1016/S1474-4422(08)70116-9  0.402
2008 Lin CH, Tzen KY, Yu CY, Tai CH, Farrer MJ, Wu RM. LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies. Journal of Biomedical Science. 15: 661-7. PMID 18523869 DOI: 10.1007/s11373-008-9260-0  0.404
2008 Myhre R, Toft M, Kachergus J, Hulihan MM, Aasly JO, Klungland H, Farrer MJ. Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population. Acta Neurologica Scandinavica. 118: 320-7. PMID 18485051 DOI: 10.1111/j.1600-0404.2008.01019.x  0.314
2008 Ross OA, Wu YR, Lee MC, Funayama M, Chen ML, Soto AI, Mata IF, Lee-Chen GJ, Chen CM, Tang M, Zhao Y, Hattori N, Farrer MJ, Tan EK, Wu RM. Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Annals of Neurology. 64: 88-92. PMID 18412265 DOI: 10.1002/ana.21405  0.348
2008 Myhre R, Klungland H, Farrer MJ, Aasly JO. Genetic association study of synphilin-1 in idiopathic Parkinson's disease. Bmc Medical Genetics. 9: 19. PMID 18366718 DOI: 10.1186/1471-2350-9-19  0.415
2008 Wider C, Skipper L, Solida A, Brown L, Farrer M, Dickson D, Wszolek ZK, Vingerhoets FJ. Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family. Parkinsonism & Related Disorders. 14: 465-70. PMID 18342564 DOI: 10.1016/J.Parkreldis.2007.11.013  0.51
2008 Haugarvoll K, Rademakers R, Kachergus JM, Nuytemans K, Ross OA, Gibson JM, Tan EK, Gaig C, Tolosa E, Goldwurm S, Guidi M, Riboldazzi G, Brown L, Walter U, Benecke R, ... ... Farrer MJ, et al. Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. Neurology. 70: 1456-60. PMID 18337586 DOI: 10.1212/01.Wnl.0000304044.22253.03  0.411
2008 Brighina L, Frigerio R, Schneider NK, Lesnick TG, de Andrade M, Cunningham JM, Farrer MJ, Lincoln SJ, Checkoway H, Rocca WA, Maraganore DM. Alpha-synuclein, pesticides, and Parkinson disease: a case-control study. Neurology. 70: 1461-9. PMID 18322262 DOI: 10.1212/01.Wnl.0000304049.31377.F2  0.334
2008 Wider C, Melquist S, Hauf M, Solida A, Cobb SA, Kachergus JM, Gass J, Coon KD, Baker M, Cannon A, Stephan DA, Schorderet DF, Ghika J, Burkhard PR, Kapatos G, ... ... Farrer MJ, et al. Study of a Swiss dopa-responsive dystonia family with a deletion in GCH1: redefining DYT14 as DYT5. Neurology. 70: 1377-83. PMID 17804835 DOI: 10.1212/01.Wnl.0000275527.35752.C5  0.546
2008 Farrer MJ, Gibson R, Hentati F. The ancestry of LRRK2 Gly2019Ser parkinsonism - Authors' reply The Lancet Neurology. 7: 770-771. DOI: 10.1016/S1474-4422(08)70179-0  0.318
2008 Miles S, Melrose H, Knight J, Lincoln S, Farrer M, Lewis J. P1-106: LRRK2 as a common link between tauopathies and synucleinopathies Alzheimer's & Dementia. 4: T237-T238. DOI: 10.1016/J.Jalz.2008.05.693  0.311
2008 Ross OA, Braithwaite AT, Farrer MJ. Genetics of Parkinson's Disease Parkinson's Disease. 9-33. DOI: 10.1016/B978-0-12-374028-1.00002-6  0.338
2007 Winkler S, Hagenah J, Lincoln S, Heckman M, Haugarvoll K, Lohmann-Hedrich K, Kostic V, Farrer M, Klein C. alpha-Synuclein and Parkinson disease susceptibility. Neurology. 69: 1745-50. PMID 17872362 DOI: 10.1212/01.Wnl.0000275524.15125.F4  0.458
2007 Perez-Pastene C, Cobb SA, Díaz-Grez F, Hulihan MM, Miranda M, Venegas P, Godoy OT, Kachergus JM, Ross OA, Layson L, Farrer MJ, Segura-Aguilar J. Lrrk2 mutations in South America: A study of Chilean Parkinson's disease. Neuroscience Letters. 422: 193-7. PMID 17614198 DOI: 10.1016/j.neulet.2007.06.021  0.388
2007 Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, ... ... Farrer MJ, et al. A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience. 147: 1047-58. PMID 17611037 DOI: 10.1016/J.Neuroscience.2007.05.027  0.352
2007 Taylor JM, Song YJ, Huang Y, Farrer MJ, Delatycki MB, Halliday GM, Lockhart PJ. Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases. Neurobiology of Disease. 27: 238-47. PMID 17590346 DOI: 10.1016/j.nbd.2007.04.014  0.373
2007 Brighina L, Okubadejo NU, Schneider NK, Lesnick TG, de Andrade M, Cunningham JM, Farrer MJ, Lincoln SJ, Rocca WA, Maraganore DM. Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study. Neuroscience Letters. 420: 229-34. PMID 17556099 DOI: 10.1016/j.neulet.2007.05.021  0.359
2007 González-Fernández MC, Lezcano E, Ross OA, Gómez-Esteban JC, Gómez-Busto F, Velasco F, Alvarez-Alvarez M, Rodríguez-Martínez MB, Ciordia R, Zarranz JJ, Farrer MJ, Mata IF, de Pancorbo MM. Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain. Parkinsonism & Related Disorders. 13: 509-15. PMID 17540608 DOI: 10.1016/j.parkreldis.2007.04.003  0.393
2007 Ross OA, Gosal D, Stone JT, Lincoln SJ, Heckman MG, Irvine GB, Johnston JA, Gibson JM, Farrer MJ, Lynch T. Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Mechanisms of Ageing and Development. 128: 378-82. PMID 17531291 DOI: 10.1016/J.Mad.2007.04.002  0.413
2007 Toft M, Haugarvoll K, Ross OA, Farrer MJ, Aasly JO. LRRK2 and Parkinson's disease in Norway. Acta Neurologica Scandinavica. Supplementum. 187: 72-5. PMID 17419834 DOI: 10.1111/j.1600-0404.2007.00852.x  0.408
2007 Dächsel JC, Taylor JP, Mok SS, Ross OA, Hinkle KM, Bailey RM, Hines JH, Szutu J, Madden B, Petrucelli L, Farrer MJ. Identification of potential protein interactors of Lrrk2. Parkinsonism & Related Disorders. 13: 382-5. PMID 17400507 DOI: 10.1016/J.Parkreldis.2007.01.008  0.497
2007 Ross OA, Haugarvoll K, Stone JT, Heckman MG, White LR, Aasly JO, Mark Gibson J, Lynch T, Wszolek ZK, Uitti RJ, Farrer MJ. Lack of evidence for association of Parkin promoter polymorphism (PRKN-258) with increased risk of Parkinson's disease. Parkinsonism & Related Disorders. 13: 386-8. PMID 17400506 DOI: 10.1016/J.Parkreldis.2007.01.010  0.4
2007 White LR, Toft M, Kvam SN, Farrer MJ, Aasly JO. MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease. Journal of Neuroscience Research. 85: 1288-94. PMID 17385669 DOI: 10.1002/jnr.21240  0.375
2007 Ross OA, Farrer MJ, Wu RM. Common variants in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 899-900. PMID 17377919 DOI: 10.1002/mds.21463  0.359
2007 Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL, Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, Adler C, ... ... Farrer MJ, et al. Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms. American Journal of Human Genetics. 80: 769-78. PMID 17357082 DOI: 10.1086/513320  0.473
2007 Haugarvoll K, Toft M, Ross OA, White LR, Aasly JO, Farrer MJ. Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway. Neuroscience Letters. 416: 299-301. PMID 17324517 DOI: 10.1016/j.neulet.2007.02.020  0.422
2007 Baba Y, Baker MC, Le Ber I, Brice A, Maeck L, Kohlhase J, Yasuda M, Stoppe G, Bugiani O, Sperfeld AD, Tsuboi Y, Uitti RJ, Farrer MJ, Ghetti B, Hutton ML, et al. Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation. Journal of Neural Transmission (Vienna, Austria : 1996). 114: 947-50. PMID 17318302 DOI: 10.1007/S00702-007-0632-9  0.554
2007 Fuchs J, Nilsson C, Kachergus J, Munz M, Larsson EM, Schüle B, Langston JW, Middleton FA, Ross OA, Hulihan M, Gasser T, Farrer MJ. Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology. 68: 916-22. PMID 17251522 DOI: 10.1212/01.wnl.0000254458.17630.c5  0.307
2007 Haugarvoll K, Toft M, Ross OA, Stone JT, Heckman MG, White LR, Lynch T, Gibson JM, Wszolek ZK, Uitti RJ, Aasly JO, Farrer MJ. ELAVL4, PARK10, and the Celts. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 585-7. PMID 17230446 DOI: 10.1002/Mds.21336  0.326
2007 Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, Hinkle KM, Stone JT, Ross OA, Hauser R, Aasly J, Gasser T, Payami H, Wszolek ZK, Farrer MJ. Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. Neurogenetics. 8: 95-102. PMID 17225181 DOI: 10.1007/s10048-006-0075-8  0.367
2007 Farrer MJ, Stone JT, Lin CH, Dächsel JC, Hulihan MM, Haugarvoll K, Ross OA, Wu RM. Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia. Parkinsonism & Related Disorders. 13: 89-92. PMID 17222580 DOI: 10.1016/j.parkreldis.2006.12.001  0.386
2007 Toft M, Mata IF, Ross OA, Kachergus J, Hulihan MM, Haugarvoll K, Stone JT, Blazquez M, Gibson JM, Aasly JO, White LR, Lynch T, Adler CH, Gwinn-Hardy K, Farrer MJ. Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 389-92. PMID 17216639 DOI: 10.1002/Mds.21217  0.406
2007 Papapetropoulos S, Farrer MJ, Stone JT, Milkovic NM, Ross OA, Calvo L, McQuorquodale D, Mash DC. Phenotypic associations of tau and ApoE in Parkinson's disease. Neuroscience Letters. 414: 141-4. PMID 17204369 DOI: 10.1016/J.Neulet.2006.12.008  0.401
2007 Toft M, Myhre R, Pielsticker L, White LR, Aasly JO, Farrer MJ. PINK1 mutation heterozygosity and the risk of Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 82-4. PMID 17172567 DOI: 10.1136/jnnp.2006.097840  0.42
2007 Dächsel JC, Ross OA, Mata IF, Kachergus J, Toft M, Cannon A, Baker M, Adamson J, Hutton M, Dickson DW, Farrer MJ. Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions. Acta Neuropathologica. 113: 601-6. PMID 17151837 DOI: 10.1007/S00401-006-0178-1  0.549
2007 Ross O, Aasly J, White L, Gibson J, Lynch T, Uitti R, Wszolek Z, Lin C, Wu R, Farrer M. 2.011 Familial genes in sporadic Parkinson's disease Parkinsonism & Related Disorders. 13: S88. DOI: 10.1016/S1353-8020(08)70579-0  0.347
2006 Dächsel JC, Mata IF, Ross OA, Taylor JP, Lincoln SJ, Hinkle KM, Huerta C, Ribacoba R, Blazquez M, Alvarez V, Farrer MJ. Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2. Neuroscience Letters. 410: 80-4. PMID 17095157 DOI: 10.1016/j.neulet.2006.06.068  0.405
2006 Whaley NR, Uitti RJ, Dickson DW, Farrer MJ, Wszolek ZK. Clinical and pathologic features of families with LRRK2-associated Parkinson's disease. Journal of Neural Transmission. Supplementum. 221-9. PMID 17017533 DOI: 10.1007/978-3-211-45295-0_34  0.446
2006 Ishihara L, Warren L, Gibson R, Amouri R, Lesage S, Dürr A, Tazir M, Wszolek ZK, Uitti RJ, Nichols WC, Griffith A, Hattori N, Leppert D, Watts R, Zabetian CP, ... ... Farrer MJ, et al. Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations. Archives of Neurology. 63: 1250-4. PMID 16966502 DOI: 10.1001/Archneur.63.9.1250  0.412
2006 Papapetropoulos S, Singer C, Ross OA, Toft M, Johnson JL, Farrer MJ, Mash DC. Clinical heterogeneity of the LRRK2 G2019S mutation. Archives of Neurology. 63: 1242-6. PMID 16966501 DOI: 10.1001/Archneur.63.9.1242  0.39
2006 Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Krüger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin MC, Checkoway H, et al. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. Jama. 296: 661-70. PMID 16896109 DOI: 10.1001/Jama.296.6.661  0.651
2006 Baba Y, Uitti RJ, Farrer MJ, Wszolek ZK. Atypical Parkinsonism and SCA8. Parkinsonism & Related Disorders. 12: 396. PMID 16846746 DOI: 10.1016/j.parkreldis.2006.06.001  0.385
2006 Mata IF, Ross OA, Kachergus J, Huerta C, Ribacoba R, Moris G, Blazquez M, Guisasola LM, Salvador C, Martinez C, Farrer M, Alvarez V. LRRK2 mutations are a common cause of Parkinson's disease in Spain. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 13: 391-4. PMID 16643318 DOI: 10.1111/J.1468-1331.2006.01256.X  0.508
2006 Melrose HL, Lincoln SJ, Tyndall GM, Farrer MJ. Parkinson's disease: a rethink of rodent models. Experimental Brain Research. 173: 196-204. PMID 16639500 DOI: 10.1007/s00221-006-0461-3  0.392
2006 Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu CS, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, ... ... Farrer MJ, et al. Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 1102-8. PMID 16622854 DOI: 10.1002/Mds.20886  0.393
2006 Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA. LRRK2 in Parkinson's disease: protein domains and functional insights. Trends in Neurosciences. 29: 286-93. PMID 16616379 DOI: 10.1016/J.Tins.2006.03.006  0.426
2006 Baba Y, Markopoulou K, Putzke JD, Whaley NR, Farrer MJ, Wszolek ZK, Uitti RJ. Phenotypic commonalities in familial and sporadic Parkinson disease. Archives of Neurology. 63: 579-83. PMID 16606772 DOI: 10.1001/archneur.63.4.579  0.367
2006 Farrer MJ. Genetics of Parkinson disease: paradigm shifts and future prospects. Nature Reviews. Genetics. 7: 306-18. PMID 16543934 DOI: 10.1038/nrg1831  0.32
2006 Melrose H, Lincoln S, Tyndall G, Dickson D, Farrer M. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience. 139: 791-4. PMID 16504409 DOI: 10.1016/J.Neuroscience.2006.01.017  0.439
2006 Toft M, Pielsticker L, Ross OA, Aasly JO, Farrer MJ. Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population. Neurology. 66: 415-7. PMID 16476943 DOI: 10.1212/01.wnl.0000196492.80676.7c  0.428
2006 Giasson BI, Covy JP, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin VM. Biochemical and pathological characterization of Lrrk2. Annals of Neurology. 59: 315-22. PMID 16437584 DOI: 10.1002/Ana.20791  0.444
2006 Ross OA, Toft M, Whittle AJ, Johnson JL, Papapetropoulos S, Mash DC, Litvan I, Gordon MF, Wszolek ZK, Farrer MJ, Dickson DW. Lrrk2 and Lewy body disease. Annals of Neurology. 59: 388-93. PMID 16437559 DOI: 10.1002/Ana.20731  0.39
2006 Ross OA, Whittle AJ, Cobb SA, Hulihan MM, Lincoln SJ, Toft M, Farrer MJ, Dickson DW. Lrrk2 R1441 substitution and progressive supranuclear palsy. Neuropathology and Applied Neurobiology. 32: 23-5. PMID 16409550 DOI: 10.1111/J.1365-2990.2006.00693.X  0.32
2006 Taylor JP, Mata IF, Farrer MJ. LRRK2: a common pathway for parkinsonism, pathogenesis and prevention? Trends in Molecular Medicine. 12: 76-82. PMID 16406842 DOI: 10.1016/j.molmed.2005.12.004  0.416
2006 Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, et al. Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Annals of Neurology. 59: 298-309. PMID 16358335 DOI: 10.1002/ana.20753  0.531
2006 Rademakers R, Sleegers K, Pals P, Nuytemans K, Lohmann E, Durr A, Engelborghs S, Pooter Td, Broeck MVd, Pickut B, Cruts M, Deyn PD, Farrer M, Brice A, Broeckhoven CV. P3-159: MAPT H1 subhaplotyping in european PD association samples implicates tau splicing in early-onset parkinson’s disease susceptibility Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1427  0.449
2005 Maraganore DM, de Andrade M, Lesnick TG, Strain KJ, Farrer MJ, Rocca WA, Pant PV, Frazer KA, Cox DR, Ballinger DG. High-resolution whole-genome association study of Parkinson disease. American Journal of Human Genetics. 77: 685-93. PMID 16252231 DOI: 10.1086/496902  0.304
2005 Skipper L, Shen H, Chua E, Bonnard C, Kolatkar P, Tan LC, Jamora RD, Puvan K, Puong KY, Zhao Y, Pavanni R, Wong MC, Yuen Y, Farrer M, Liu JJ, et al. Analysis of LRRK2 functional domains in nondominant Parkinson disease. Neurology. 65: 1319-21. PMID 16247070 DOI: 10.1212/01.Wnl.0000180517.70572.37  0.484
2005 Mata IF, Kachergus JM, Taylor JP, Lincoln S, Aasly J, Lynch T, Hulihan MM, Cobb SA, Wu RM, Lu CS, Lahoz C, Wszolek ZK, Farrer MJ. Lrrk2 pathogenic substitutions in Parkinson's disease. Neurogenetics. 6: 171-7. PMID 16172858 DOI: 10.1007/s10048-005-0005-1  0.418
2005 Farrer M, Stone J, Mata IF, Lincoln S, Kachergus J, Hulihan M, Strain KJ, Maraganore DM. LRRK2 mutations in Parkinson disease. Neurology. 65: 738-40. PMID 16157908 DOI: 10.1212/01.Wnl.0000169023.51764.B0  0.51
2005 Gosal D, Ross OA, Wiley J, Irvine GB, Johnston JA, Toft M, Mata IF, Kachergus J, Hulihan M, Taylor JP, Lincoln SJ, Farrer MJ, Lynch T, Mark Gibson J. Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD. Parkinsonism & Related Disorders. 11: 349-52. PMID 16102999 DOI: 10.1016/J.Parkreldis.2005.05.004  0.445
2005 Toft M, Sando SB, Melquist S, Ross OA, White LR, Aasly JO, Farrer MJ. LRRK2 mutations are not common in Alzheimer's disease. Mechanisms of Ageing and Development. 126: 1201-5. PMID 16087219 DOI: 10.1016/J.Mad.2005.06.010  0.321
2005 Adams JR, van Netten H, Schulzer M, Mak E, Mckenzie J, Strongosky A, Sossi V, Ruth TJ, Lee CS, Farrer M, Gasser T, Uitti RJ, Calne DB, Wszolek ZK, Stoessl AJ. PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation. Brain : a Journal of Neurology. 128: 2777-85. PMID 16081470 DOI: 10.1093/Brain/Awh607  0.486
2005 Ross OA, Farrer MJ. Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease. Biochemical Society Transactions. 33: 586-90. PMID 16042550 DOI: 10.1042/BST0330586  0.447
2005 Tan EK, Shen H, Tan LC, Farrer M, Yew K, Chua E, Jamora RD, Puvan K, Puong KY, Zhao Y, Pavanni R, Wong MC, Yih Y, Skipper L, Liu JJ. The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients. Neuroscience Letters. 384: 327-9. PMID 15955629 DOI: 10.1016/J.Neulet.2005.04.103  0.49
2005 Mata IF, Taylor JP, Kachergus J, Hulihan M, Huerta C, Lahoz C, Blazquez M, Guisasola LM, Salvador C, Ribacoba R, Martinez C, Farrer M, Alvarez V. LRRK2 R1441G in Spanish patients with Parkinson's disease. Neuroscience Letters. 382: 309-11. PMID 15925109 DOI: 10.1016/J.Neulet.2005.03.033  0.525
2005 Martinez M, Brice A, Vaughan JR, Zimprich A, Breteler MM, Meco G, Filla A, Farrer MJ, Bétard C, Singleton A, Hardy J, De Michele G, Bonifati V, Oostra BA, Gasser T, et al. Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 136: 72-4. PMID 15924299 DOI: 10.1002/Ajmg.B.30196  0.614
2005 Facheris M, Strain KJ, Lesnick TG, de Andrade M, Bower JH, Ahlskog JE, Cunningham JM, Lincoln S, Farrer MJ, Rocca WA, Maraganore DM. UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study. Neuroscience Letters. 381: 131-4. PMID 15882803 DOI: 10.1016/j.neulet.2005.02.008  0.351
2005 Baba Y, Tsuboi Y, Baker MC, Uitti RJ, Hutton ML, Dickson DW, Farrer M, Putzke JD, Woodruff BK, Ghetti B, Murrell JR, Boeve BF, Petersen RC, Verpillat P, Brice A, et al. The effect of tau genotype on clinical features in FTDP-17. Parkinsonism & Related Disorders. 11: 205-8. PMID 15878580 DOI: 10.1016/J.Parkreldis.2005.01.003  0.547
2005 Mata IF, Alvarez V, Coto E, Blazquez M, Guisasola LM, Salvador C, Kachergus JM, Lincoln SJ, Farrer M. Homozygous partial genomic triplication of the parkin gene in early-onset parkinsonism. Neuroscience Letters. 380: 257-9. PMID 15862897 DOI: 10.1016/J.Neulet.2005.01.051  0.443
2005 Aasly JO, Toft M, Fernandez-Mata I, Kachergus J, Hulihan M, White LR, Farrer M. Clinical features of LRRK2-associated Parkinson's disease in central Norway. Annals of Neurology. 57: 762-5. PMID 15852371 DOI: 10.1002/Ana.20456  0.527
2005 Toft M, Mata IF, Kachergus JM, Ross OA, Farrer MJ. LRRK2 mutations and Parkinsonism. Lancet. 365: 1229-30. PMID 15811454 DOI: 10.1016/S0140-6736(05)74809-1  0.349
2005 Krygowska-Wajs A, Kachergus JM, Hulihan MM, Farrer MJ, Searcy JA, Booij J, Berendse HW, Wolters ECh, Wszolek ZK. Clinical and genetic evaluation of 8 Polish families with levodopa-responsive parkinsonism. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 1487-502. PMID 15785861 DOI: 10.1007/s00702-005-0290-8  0.35
2005 Mamah CE, Lesnick TG, Lincoln SJ, Strain KJ, de Andrade M, Bower JH, Ahlskog JE, Rocca WA, Farrer MJ, Maraganore DM. Interaction of alpha-synuclein and tau genotypes in Parkinson's disease. Annals of Neurology. 57: 439-43. PMID 15732111 DOI: 10.1002/ana.20387  0.338
2005 Kachergus J, Mata IF, Hulihan M, Taylor JP, Lincoln S, Aasly J, Gibson JM, Ross OA, Lynch T, Wiley J, Payami H, Nutt J, Maraganore DM, Czyzewski K, Styczynska M, ... ... Farrer MJ, et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. American Journal of Human Genetics. 76: 672-80. PMID 15726496 DOI: 10.1086/429256  0.409
2005 Wu RM, Bounds R, Lincoln S, Hulihan M, Lin CH, Hwu WL, Chen J, Gwinn-Hardy K, Farrer M. Parkin mutations and early-onset parkinsonism in a Taiwanese cohort. Archives of Neurology. 62: 82-7. PMID 15642853 DOI: 10.1001/Archneur.62.1.82  0.469
2005 Prestel J, Sharma M, Leitner P, Zimprich A, Vaughan JR, Dürr A, Bonifati V, De Michele G, Hanagasi HA, Farrer M, Hofer A, Asmus F, Volpe G, Meco G, Brice A, et al. PARK11 is not linked with Parkinson's disease in European families. European Journal of Human Genetics : Ejhg. 13: 193-7. PMID 15523496 DOI: 10.1038/Sj.Ejhg.5201317  0.48
2005 Toft M, Aasly J, Bisceglio G, Adler CH, Uitti RJ, Krygowska-Wajs A, Lynch T, Wszolek ZK, Farrer MJ. Parkinsonism, FXTAS, and FMR1 premutations. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 230-3. PMID 15390127 DOI: 10.1002/Mds.20297  0.346
2004 Lockhart PJ, Kachergus J, Lincoln S, Hulihan M, Bisceglio G, Thomas N, Dickson D, Farrer MJ. Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease. Journal of Molecular Neuroscience : Mn. 24: 337-42. PMID 15655258 DOI: 10.1385/Jmn:24:3:337  0.317
2004 Morris HR, Steele JC, Crook R, Wavrant-De Vrièze F, Onstead-Cardinale L, Gwinn-Hardy K, Wood NW, Farrer M, Lees AJ, McGeer PL, Siddique T, Hardy J, Perez-Tur J. Genome-wide analysis of the parkinsonism-dementia complex of Guam. Archives of Neurology. 61: 1889-97. PMID 15596609 DOI: 10.1001/Archneur.61.12.1889  0.732
2004 Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 44: 601-7. PMID 15541309 DOI: 10.1016/J.Neuron.2004.11.005  0.523
2004 Pals P, Lincoln S, Manning J, Heckman M, Skipper L, Hulihan M, Van den Broeck M, De Pooter T, Cras P, Crook J, Van Broeckhoven C, Farrer MJ. alpha-Synuclein promoter confers susceptibility to Parkinson's disease. Annals of Neurology. 56: 591-5. PMID 15455394 DOI: 10.1002/ana.20268  0.416
2004 Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, Waucquier N, Defebvre L, Amouyel P, Farrer M, Destée A. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet. 364: 1167-9. PMID 15451224 DOI: 10.1016/S0140-6736(04)17103-1  0.673
2004 Lockhart PJ, Bounds R, Hulihan M, Kachergus J, Lincoln S, Lin CH, Wu RM, Farrer MJ. Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. 19: 1065-9. PMID 15372597 DOI: 10.1002/mds.20082  0.386
2004 Lockhart PJ, Hulihan M, Lincoln S, Hussey J, Skipper L, Bisceglio G, Wilkes K, Farrer MJ. Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis. Dna Sequence : the Journal of Dna Sequencing and Mapping. 15: 9-14. PMID 15354349  0.318
2004 Hope AD, Myhre R, Kachergus J, Lincoln S, Bisceglio G, Hulihan M, Farrer MJ. Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease. Neuroscience Letters. 367: 97-100. PMID 15308306 DOI: 10.1016/j.neulet.2004.05.100  0.359
2004 Maraganore DM, Wilkes K, Lesnick TG, Strain KJ, de Andrade M, Rocca WA, Bower JH, Ahlskog JE, Lincoln S, Farrer MJ. A limited role for DJ1 in Parkinson disease susceptibility. Neurology. 63: 550-3. PMID 15304593  0.333
2004 Skipper L, Wilkes K, Toft M, Baker M, Lincoln S, Hulihan M, Ross OA, Hutton M, Aasly J, Farrer M. Linkage disequilibrium and association of MAPT H1 in Parkinson disease. American Journal of Human Genetics. 75: 669-77. PMID 15297935 DOI: 10.1086/424492  0.591
2004 Wiley J, Lynch T, Lincoln S, Skipper L, Hulihan M, Gosal D, Bisceglio G, Kachergus J, Hardy J, Farrer MJ. Parkinson's disease in Ireland: clinical presentation and genetic heterogeneity in patients with parkin mutations. Movement Disorders : Official Journal of the Movement Disorder Society. 19: 677-81. PMID 15197707 DOI: 10.1002/Mds.10703  0.599
2004 Furtado S, Payami H, Lockhart PJ, Hanson M, Nutt JG, Singleton AA, Singleton A, Bower J, Utti RJ, Bird TD, de la Fuente-Fernandez R, Tsuboi Y, Klimek ML, Suchowersky O, Hardy J, ... ... Farrer M, et al. Profile of families with parkinsonism-predominant spinocerebellar ataxia type 2 (SCA2). Movement Disorders : Official Journal of the Movement Disorder Society. 19: 622-9. PMID 15197699 DOI: 10.1002/Mds.20074  0.714
2004 Munhoz RP, Sa DS, Rogaeva E, Salehi-Rad S, Sato C, Medeiros H, Farrer M, Lang AE. Clinical findings in a large family with a parkin ex3delta40 mutation. Archives of Neurology. 61: 701-4. PMID 15148147 DOI: 10.1001/Archneur.61.5.701  0.423
2004 Wszolek ZK, Pfeiffer RF, Tsuboi Y, Uitti RJ, McComb RD, Stoessl AJ, Strongosky AJ, Zimprich A, Müller-Myhsok B, Farrer MJ, Gasser T, Calne DB, Dickson DW. Autosomal dominant parkinsonism associated with variable synuclein and tau pathology. Neurology. 62: 1619-22. PMID 15136696 DOI: 10.1212/01.Wnl.0000125015.06989.Db  0.388
2004 Lockhart PJ, Lincoln S, Hulihan M, Kachergus J, Wilkes K, Bisceglio G, Mash DC, Farrer MJ. DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function. Journal of Medical Genetics. 41: e22. PMID 14985393 DOI: 10.1136/Jmg.2003.011106  0.451
2004 Mata IF, Lockhart PJ, Farrer MJ. Parkin genetics: one model for Parkinson's disease. Human Molecular Genetics. 13: R127-33. PMID 14976155 DOI: 10.1093/hmg/ddh089  0.398
2004 Farrer M, Kachergus J, Forno L, Lincoln S, Wang DS, Hulihan M, Maraganore D, Gwinn-Hardy K, Wszolek Z, Dickson D, Langston JW. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Annals of Neurology. 55: 174-9. PMID 14755720 DOI: 10.1002/Ana.10846  0.415
2004 Lockhart PJ, O'Farrell CA, Farrer MJ. It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG). Movement Disorders : Official Journal of the Movement Disorder Society. 19: 101-4. PMID 14743368 DOI: 10.1002/mds.20000  0.329
2004 Edland SD, Slager S, Farrer M. Genetic association studies in Alzheimer's disease research: challenges and opportunities. Statistics in Medicine. 23: 169-78. PMID 14716719 DOI: 10.1002/Sim.1706  0.357
2004 Zimprich A, Müller-Myhsok B, Farrer M, Leitner P, Sharma M, Hulihan M, Lockhart P, Strongosky A, Kachergus J, Calne DB, Stoessl J, Uitti RJ, Pfeiffer RF, Trenkwalder C, Homann N, et al. The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. American Journal of Human Genetics. 74: 11-9. PMID 14691730 DOI: 10.1086/380647  0.574
2004 Pickering-Brown SM, Crook R, Skipper L, Mann D, Farrer M, Hutton M. P4-158 Tau H1 haplotype disease association and splice mutations: investigations into mutational mechanisms Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81716-0  0.579
2003 Lincoln SJ, Maraganore DM, Lesnick TG, Bounds R, de Andrade M, Bower JH, Hardy JA, Farrer MJ. Parkin variants in North American Parkinson's disease: cases and controls. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 1306-11. PMID 14639672 DOI: 10.1002/mds.10601  0.611
2003 Maraganore DM, Farrer MJ, Lesnick TG, de Andrade M, Bower JH, Hernandez D, Hardy JA, Rocca WA. Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 1233-9. PMID 14639662 DOI: 10.1002/mds.10547  0.586
2003 Houlden H, Lincoln S, Farrer M, Cleland PG, Hardy J, Orrell RW. Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic. Neurology. 61: 1423-6. PMID 14638969 DOI: 10.1212/01.Wnl.0000094120.09977.92  0.376
2003 Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science (New York, N.Y.). 302: 841. PMID 14593171 DOI: 10.1126/Science.1090278  0.772
2003 Cookson MR, Lockhart PJ, McLendon C, O'Farrell C, Schlossmacher M, Farrer MJ. RING finger 1 mutations in Parkin produce altered localization of the protein. Human Molecular Genetics. 12: 2957-65. PMID 14519684 DOI: 10.1093/Hmg/Ddg328  0.53
2003 Tan LC, Tanner CM, Chen R, Chan P, Farrer M, Hardy J, Langston JW. Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 758-63. PMID 12815654 DOI: 10.1002/Mds.10432  0.659
2003 Maraganore DM, de Andrade M, Lesnick TG, Farrer MJ, Bower JH, Hardy JA, Rocca WA. Complex interactions in Parkinson's disease: a two-phased approach. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 631-6. PMID 12784265 DOI: 10.1002/mds.10431  0.599
2003 Lincoln S, Wiley J, Lynch T, Langston JW, Chen R, Lang A, Rogaeva E, Sa DS, Munhoz RP, Harris J, Marder K, Klein C, Bisceglio G, Hussey J, West A, ... ... Farrer M, et al. Parkin-proven disease: common founders but divergent phenotypes. Neurology. 60: 1605-10. PMID 12771249 DOI: 10.1212/01.Wnl.0000064289.49410.A9  0.475
2003 Marx FP, Holzmann C, Strauss KM, Li L, Eberhardt O, Gerhardt E, Cookson MR, Hernandez D, Farrer MJ, Kachergus J, Engelender S, Ross CA, Berger K, Schöls L, Schulz JB, et al. Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease. Human Molecular Genetics. 12: 1223-31. PMID 12761037 DOI: 10.1093/Hmg/Ddg134  0.617
2003 Baptista MJ, O'Farrell C, Daya S, Ahmad R, Miller DW, Hardy J, Farrer MJ, Cookson MR. Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines. Journal of Neurochemistry. 85: 957-68. PMID 12716427 DOI: 10.1046/J.1471-4159.2003.01742.X  0.673
2003 Rawal N, Periquet M, Lohmann E, Lücking CB, Teive HA, Ambrosio G, Raskin S, Lincoln S, Hattori N, Guimaraes J, Horstink MW, Dos Santos Bele W, Brousolle E, Destée A, Mizuno Y, ... Farrer M, et al. New parkin mutations and atypical phenotypes in families with autosomal recessive parkinsonism. Neurology. 60: 1378-81. PMID 12707451 DOI: 10.1212/01.Wnl.0000056167.89221.Be  0.464
2003 Payami H, Nutt J, Gancher S, Bird T, McNeal MG, Seltzer WK, Hussey J, Lockhart P, Gwinn-Hardy K, Singleton AA, Singleton AB, Hardy J, Farrer M. SCA2 may present as levodopa-responsive parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 425-9. PMID 12671950 DOI: 10.1002/Mds.10375  0.712
2003 Krygowska-Wajs A, Hussey JM, Hulihan M, Farrer MJ, Tsuboi Y, Uitti RJ, Wszolek ZK. Two large Polish kindreds with levodopa-responsive Parkinsonism not linked to known Parkinsonian genes and loci. Parkinsonism & Related Disorders. 9: 193-200. PMID 12618053 DOI: 10.1016/S1353-8020(02)00036-6  0.425
2003 Wszolek ZK, Tsuboi Y, Farrer M, Uitti RJ, Hutton ML. Hereditary tauopathies and parkinsonism. Advances in Neurology. 91: 153-63. PMID 12442674  0.599
2002 Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 36: 1007-19. PMID 12495618 DOI: 10.1016/S0896-6273(02)01125-X  0.727
2002 Walker RH, Friedman J, Wiener J, Hobler R, Gwinn-Hardy K, Adam A, DeWolfe J, Gibbs R, Baker M, Farrer M, Hutton M, Hardy J. A family with a tau P301L mutation presenting with parkinsonism. Parkinsonism & Related Disorders. 9: 121-3. PMID 12473404 DOI: 10.1016/S1353-8020(02)00003-2  0.694
2002 Goudreau JL, Maraganore DM, Farrer MJ, Lesnick TG, Singleton AB, Bower JH, Hardy JA, Rocca WA. Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 1305-11. PMID 12465073 DOI: 10.1002/Mds.10268  0.788
2002 Furtado S, Farrer M, Tsuboi Y, Klimek ML, de la Fuente-Fernández R, Hussey J, Lockhart P, Calne DB, Suchowersky O, Stoessl AJ, Wszolek ZK. SCA-2 presenting as parkinsonism in an Alberta family: clinical, genetic, and PET findings. Neurology. 59: 1625-7. PMID 12451209 DOI: 10.1212/01.Wnl.0000035625.19871.Dc  0.468
2002 Skipper L, Farrer M. Parkinson's genetics: molecular insights for the new millennium. Neurotoxicology. 23: 503-14. PMID 12428722 DOI: 10.1016/S0161-813X(02)00038-4  0.473
2002 West AB, Maraganore D, Crook J, Lesnick T, Lockhart PJ, Wilkes KM, Kapatos G, Hardy JA, Farrer MJ. Functional association of the parkin gene promoter with idiopathic Parkinson's disease. Human Molecular Genetics. 11: 2787-92. PMID 12374768 DOI: 10.1093/Hmg/11.22.2787  0.633
2002 Subramony SH, Hernandez D, Adam A, Smith-Jefferson S, Hussey J, Gwinn-Hardy K, Lynch T, McDaniel O, Hardy J, Farrer M, Singleton A. Ethnic differences in the expression of neurodegenerative disease: Machado-Joseph disease in Africans and Caucasians. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 1068-71. PMID 12360561 DOI: 10.1002/Mds.10241  0.675
2002 Wu RM, Shan DE, Sun CM, Liu RS, Hwu WL, Tai CH, Hussey J, West A, Gwinn-Hardy K, Hardy J, Chen J, Farrer M, Lincoln S. Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 670-5. PMID 12210855 DOI: 10.1002/Mds.10184  0.577
2002 West A, Periquet M, Lincoln S, Lücking CB, Nicholl D, Bonifati V, Rawal N, Gasser T, Lohmann E, Deleuze JF, Maraganore D, Levey A, Wood N, Dürr A, Hardy J, ... ... Farrer M, et al. Complex relationship between Parkin mutations and Parkinson disease. American Journal of Medical Genetics. 114: 584-91. PMID 12116199 DOI: 10.1002/Ajmg.10525  0.632
2002 Maraganore DM, Farrer MJ, McDonnell SK, Elbaz A, Schaid DJ, Hardy JA, Rocca WA. Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 509-12. PMID 12112198 DOI: 10.1002/mds.1253  0.566
2002 Lockhart PJ, Holtom B, Lincoln S, Hussey J, Zimprich A, Gasser T, Wszolek ZK, Hardy J, Farrer MJ. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. Gene. 285: 229-37. PMID 12039050 DOI: 10.1016/S0378-1119(02)00402-X  0.564
2002 Farrer M, Skipper L, Berg M, Bisceglio G, Hanson M, Hardy J, Adam A, Gwinn-Hardy K, Aasly J. The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population. Neuroscience Letters. 322: 83-6. PMID 11958849 DOI: 10.1016/S0304-3940(02)00106-4  0.628
2002 Racette BA, Rundle M, Wang JC, Goate A, Saccone NL, Farrer M, Lincoln S, Hussey J, Smemo S, Lin J, Suarez B, Parsian A, Perlmutter JS. A multi-incident, Old-Order Amish family with PD. Neurology. 58: 568-74. PMID 11865134 DOI: 10.1212/Wnl.58.4.568  0.585
2002 Farrer M, Hardy J, Hutton M, Maraganore D, Tsuboi Y, Wszolek ZK. Identifying genetic factors in Parkinson disease. Jama. 287: 715-6. PMID 11851532  0.658
2002 Nicholl DJ, Vaughan JR, Khan NL, Ho SL, Aldous DE, Lincoln S, Farrer M, Gayton JD, Davis MB, Piccini P, Daniel SE, Lennox GG, Brooks DJ, Williams AC, Wood NW. Two large British kindreds with familial Parkinson's disease: a clinico-pathological and genetic study. Brain : a Journal of Neurology. 125: 44-57. PMID 11834592 DOI: 10.1093/Brain/Awf013  0.494
2002 Gwinn-Hardy K, Farrer M. Parkinson's genetics: an embarrassment of riches. Annals of Neurology. 51: 7-8. PMID 11782975 DOI: 10.1002/Ana.10091  0.401
2001 O'Farrell C, Murphy DD, Petrucelli L, Singleton AB, Hussey J, Farrer M, Hardy J, Dickson DW, Cookson MR. Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells. Brain Research. Molecular Brain Research. 97: 94-102. PMID 11744167 DOI: 10.1016/S0169-328X(01)00292-3  0.778
2001 Maraganore DM, Hernandez DG, Singleton AB, Farrer MJ, McDonnell SK, Hutton ML, Hardy JA, Rocca WA. Case-Control study of the extended tau gene haplotype in Parkinson's disease. Annals of Neurology. 50: 658-61. PMID 11706972 DOI: 10.1002/ana.1228  0.647
2001 West AB, Zimprich A, Lockhart PJ, Farrer M, Singleton A, Holtom B, Lincoln S, Hofer A, Hill L, Müller-Myhsok B, Wszolek ZK, Hardy J, Gasser T. Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. European Journal of Human Genetics : Ejhg. 9: 659-66. PMID 11571553 DOI: 10.1038/Sj.Ejhg.5200698  0.646
2001 Farrer M, Chan P, Chen R, Tan L, Lincoln S, Hernandez D, Forno L, Gwinn-Hardy K, Petrucelli L, Hussey J, Singleton A, Tanner C, Hardy J, Langston JW. Lewy bodies and parkinsonism in families with parkin mutations. Annals of Neurology. 50: 293-300. PMID 11558785 DOI: 10.1002/Ana.1132  0.751
2001 West A, Farrer M, Petrucelli L, Cookson M, Lockhart P, Hardy J. Identification and characterization of the human parkin gene promoter. Journal of Neurochemistry. 78: 1146-52. PMID 11553688 DOI: 10.1046/J.1471-4159.2001.00512.X  0.699
2001 Farrer M, Maraganore DM, Lockhart P, Singleton A, Lesnick TG, de Andrade M, West A, de Silva R, Hardy J, Hernandez D. alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Human Molecular Genetics. 10: 1847-51. PMID 11532993 DOI: 10.1093/Hmg/10.17.1847  0.645
2001 Matsuoka Y, Vila M, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease. 8: 535-9. PMID 11442360 DOI: 10.1006/Nbdi.2001.0392  0.746
2001 Farrer M, Destée A, Levecque C, Singleton A, Engelender S, Becquet E, Mouroux V, Richard F, Defebvre L, Crook R, Hernandez D, Ross CA, Hardy J, Amouyel P, Chartier-Harlin MC. Genetic analysis of synphilin-1 in familial Parkinson's disease. Neurobiology of Disease. 8: 317-23. PMID 11300726 DOI: 10.1006/Nbdi.2000.0326  0.768
2001 Dickson D, Farrer M, Lincoln S, Mason RP, Zimmerman TR, Golbe LI, Hardy J. Pathology of PD in monozygotic twins with a 20-year discordance interval. Neurology. 56: 981-2. PMID 11294946 DOI: 10.1212/Wnl.56.7.981  0.607
2001 Periquet M, Lücking C, Vaughan J, Bonifati V, Dürr A, De Michele G, Horstink M, Farrer M, Illarioshkin SN, Pollak P, Borg M, Brefel-Courbon C, Denefle P, Meco G, Gasser T, et al. Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects. American Journal of Human Genetics. 68: 617-26. PMID 11179010 DOI: 10.1086/318791  0.429
2001 Gwinn-Hardy K, Singleton A, O'Suilleabhain P, Boss M, Nicholl D, Adam A, Hussey J, Critchley P, Hardy J, Farrer M. Spinocerebellar Ataxia Type 3 Phenotypically Resembling Parkinson Disease in a Black Family Jama Neurology. 58: 296-299. PMID 11176969 DOI: 10.1001/Archneur.58.2.296  0.676
2000 Farrer M, Destée A, Becquet E, Vrièze FWD, Mouroux V, Richard F, Defebvre L, Lincoln S, Hardy J, Amouyel P, Chartier-Harlin MC. Linkage exclusion in French families with probable Parkinson's disease Movement Disorders. 15: 1075-1083. PMID 11104189 DOI: 10.1002/1531-8257(200011)15:6<1075::Aid-Mds1004>3.0.Co;2-2  0.734
2000 Ko L, Mehta ND, Farrer M, Easson C, Hussey J, Yen S, Hardy J, Yen SH. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein. Journal of Neurochemistry. 75: 2546-54. PMID 11080208 DOI: 10.1046/J.1471-4159.2000.0752546.X  0.594
2000 Gwinn-Hardy K, Chen JY, Liu HC, Liu TY, Boss M, Seltzer W, Adam A, Singleton A, Koroshetz W, Waters C, Hardy J, Farrer M. Spinocerebellar ataxia type 2 with parkinsonism in ethnic Chinese. Neurology. 55: 800-5. PMID 10993999 DOI: 10.1212/Wnl.55.6.800  0.645
2000 Gwinn-Hardy K, Mehta ND, Farrer M, Maraganore D, Muenter M, Yen SH, Hardy J, Dickson DW. Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p. Acta Neuropathologica. 99: 663-72. PMID 10867800 DOI: 10.1007/S004010051177  0.61
2000 Gwinn-Hardy KA, Crook R, Lincoln S, Adler CH, Caviness JN, Hardy J, Farrer M. A kindred with Parkinson's disease not showing genetic linkage to established loci. Neurology. 54: 504-504. PMID 10668726 DOI: 10.1212/Wnl.54.2.504  0.642
1999 Dickson DW, Liu W, Hardy J, Farrer M, Mehta N, Uitti R, Mark M, Zimmerman T, Golbe L, Sage J, Sima A, D'Amato C, Albin R, Gilman S, Yen SH. Widespread alterations of alpha-synuclein in multiple system atrophy. The American Journal of Pathology. 155: 1241-51. PMID 10514406 DOI: 10.1016/S0002-9440(10)65226-1  0.512
1999 Farrer M, Gwinn-Hardy K, Hutton M, Hardy J. The genetics of disorders with synuclein pathology and parkinsonism. Human Molecular Genetics. 8: 1901-5. PMID 10469843 DOI: 10.1093/Hmg/8.10.1901  0.707
1999 Lincoln S, Crook R, Chartier-Harlin MC, Gwinn-Hardy K, Baker M, Mouroux V, Richard F, Becquet E, Amouyel P, Destée A, Hardy J, Farrer M. No pathogenic mutations in the beta-synuclein gene in Parkinson's disease. Neuroscience Letters. 269: 107-9. PMID 10430516 DOI: 10.1016/S0304-3940(99)00420-6  0.771
1999 Lincoln S, Vaughan J, Wood N, Baker M, Adamson J, Gwinn-Hardy K, Lynch T, Hardy J, Farrer M. Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease. Neuroreport. 10: 427-9. PMID 10203348 DOI: 10.1097/00001756-199902050-00040  0.613
1999 Lincoln S, Gwinn-Hardy K, Goudreau J, Chartier-Harlin MC, Baker M, Mouroux V, Richard F, Destée A, Becquet E, Amouyel P, Lynch T, Hardy J, Farrer M. No pathogenic mutations in the persyn gene in Parkinson's disease. Neuroscience Letters. 259: 65-6. PMID 10027558 DOI: 10.1016/S0304-3940(98)00901-X  0.823
1999 Farrer M, Gwinn-Hardy K, Muenter M, DeVrieze FW, Crook R, Perez-Tur J, Lincoln S, Maraganore D, Adler C, Newman S, MacElwee K, McCarthy P, Miller C, Waters C, Hardy J. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. Human Molecular Genetics. 8: 81-5. PMID 9887334 DOI: 10.1093/Hmg/8.1.81  0.782
1999 Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B. α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins The Journal of Neuroscience. 19: 5782-5791. DOI: 10.1523/Jneurosci.19-14-05782.1999  0.663
1998 Hardy J, Pérez-Tur J, Baker M, Farrer M, Crook R, Hutton M, Johnson WG, Gwinn K, Muenter M, Rocca WA, Maraganore D. Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism. American Journal of Medical Genetics. 81: 166-71. PMID 9613857 DOI: 10.1002/(Sici)1096-8628(19980328)81:2<166::Aid-Ajmg8>3.0.Co;2-U  0.671
1998 Crook R, Verkkoniemi A, Perez-Tur J, Mehta N, Baker M, Houlden H, Farrer M, Hutton M, Lincoln S, Hardy J, Gwinn K, Somer M, Paetau A, Kalimo H, Ylikoski R, et al. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nature Medicine. 4: 452-5. PMID 9546792 DOI: 10.1038/Nm0498-452  0.778
1998 Farrer M, Wavrant-De Vrieze F, Crook R, Boles L, Perez-Tur J, Hardy J, Johnson WG, Steele J, Maraganore D, Gwinn K, Lynch T. Low frequency of alpha-synuclein mutations in familial Parkinson's disease. Annals of Neurology. 43: 394-7. PMID 9506559 DOI: 10.1002/Ana.410430320  0.732
1998 Dickson DW, Farrer MJ, Mehta ND, Perez-Tur J, Tiseo P, Yen S-, Hardy J. ANTIBODIES TO NON-AMYLOID COMPONENT OF PLAQUES (NACP) SPECIFICALLY LABEL LEWY BODIES AND LEWY NEURITES, BUT NOT OTHER INCLUSIONS IN NEURODEGENERATIVE DISEASES Journal of Neuropathology and Experimental Neurology. 57: 516. DOI: 10.1097/00005072-199805000-00205  0.455
1997 Baker M, Kwok JB, Kucera S, Crook R, Farrer M, Houlden H, Isaacs A, Lincoln S, Onstead L, Hardy J, Wittenberg L, Dodd P, Webb S, Hayward N, Tannenberg T, et al. Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22. Annals of Neurology. 42: 794-8. PMID 9392579 DOI: 10.1002/Ana.410420516  0.686
1997 Lynch T, Farrer M, Hutton M, Hardy J. Genetics of Parkinson's disease. Science. 278: 1212-1213. DOI: 10.1126/Science.278.5341.1209D  0.753
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