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Markus P. Kummer, PhD - Publications

Affiliations: 
2003-2006 Neuroscience University of California, San Diego, La Jolla, CA 
 2006-2008 Neurology University of Munster, Münster, Nordrhein-Westfalen, Germany 
 2008-2017 Neurology University of Bonn, Bonn, Nordrhein-Westfalen, Germany 
 2017- Neuroscience AbbVie 
Area:
Neurodegeneration
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wachter A, Woodbury ME, Lombardo S, Abdourahman A, Wuest C, McGlame E, Pastika T, Tamm J, Romanul N, Yanamandra K, Bennett R, Lin G, Kwon T, Liao F, Klein C, ... ... Kummer MP, et al. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta Neuropathologica. 147: 65. PMID 38557897 DOI: 10.1007/s00401-024-02704-2  0.357
2021 Kummer MP, Ising C, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Brückner M, Händler K, Schultze JL, Beyer M, Latz E, Heneka MT. Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. The Embo Journal. 40: e108662. PMID 34825707 DOI: 10.15252/embj.2021108662  0.492
2021 Rueda-Carrasco J, Martin-Bermejo MJ, Pereyra G, Mateo MI, Borroto A, Brosseron F, Kummer MP, Schwartz S, López-Atalaya JP, Alarcon B, Esteve P, Heneka MT, Bovolenta P. SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation. Embo Reports. e51696. PMID 34569685 DOI: 10.15252/embr.202051696  0.457
2021 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathologica. PMID 33609158 DOI: 10.1007/s00401-021-02263-w  0.396
2019 Herrera-Rivero M, Santarelli F, Brosseron F, Kummer MP, Heneka MT. Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression. Molecular Neurobiology. PMID 30852796 DOI: 10.1007/S12035-019-1540-3  0.633
2018 Rammes G, Seeser F, Mattusch K, Zhu K, Haas L, Kummer M, Heneka M, Herms J, Parsons CG. The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP). Neuropharmacology. PMID 30016667 DOI: 10.1016/J.Neuropharm.2018.07.021  0.709
2018 Brosseron F, Traschütz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT. Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimer's Research & Therapy. 10: 25. PMID 29482610 DOI: 10.1186/S13195-018-0353-3  0.597
2017 Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, et al. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease. Nature. 552: 355-361. PMID 29293211 DOI: 10.1038/Nature25158  0.6
2017 Traschütz A, Kummer MP, Schwartz S, Heneka MT. Variability and temporal dynamics of novel object recognition in aging male C57BL/6 mice. Behavioural Processes. PMID 29155004 DOI: 10.1016/J.Beproc.2017.11.009  0.489
2017 Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Kummer MP, Brosseron F, Gieselmann V, Heneka MT. Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags. Journal of Neuroscience Methods. PMID 28789995 DOI: 10.1016/J.Jneumeth.2017.08.005  0.452
2015 Hong GS, Schwandt T, Stein K, Schneiker B, Kummer MP, Heneka MT, Kitamura K, Kalff JC, Wehner S. Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model. The British Journal of Surgery. PMID 26313905 DOI: 10.1002/bjs.9907  0.413
2015 Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, ... ... Kummer MP, et al. Neuroinflammation in Alzheimer's disease. The Lancet. Neurology. 14: 388-405. PMID 25792098 DOI: 10.1016/S1474-4422(15)70016-5  0.593
2015 Krauthausen M, Kummer MP, Zimmermann J, Reyes-Irisarri E, Terwel D, Bulic B, Heneka MT, Müller M. CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. The Journal of Clinical Investigation. 125: 365-78. PMID 25500888 DOI: 10.1172/Jci66771  0.667
2015 Kummer MP, Schwarzenberger R, Sayah-Jeanne S, Dubernet M, Walczak R, Hum DW, Schwartz S, Axt D, Heneka MT. Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits. Molecular Neurobiology. 51: 661-71. PMID 24838579 DOI: 10.1007/S12035-014-8743-4  0.632
2015 Hong GS, Schwandt T, Stein K, Schneiker B, Kummer MP, Heneka MT, Kitamura K, Kalff JC, Wehner S. Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model British Journal of Surgery. DOI: 10.1002/bjs.9907  0.413
2014 Kummer MP, Heneka MT. Truncated and modified amyloid-beta species. Alzheimer's Research & Therapy. 6: 28. PMID 25031638 DOI: 10.1186/Alzrt258  0.583
2014 Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, et al. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human Molecular Genetics. 23: 6644-58. PMID 25027320 DOI: 10.1093/Hmg/Ddu372  0.562
2014 Kummer MP, Hammerschmidt T, Martinez A, Terwel D, Eichele G, Witten A, Figura S, Stoll M, Schwartz S, Pape HC, Schultze JL, Weinshenker D, Heneka MT, Urban I. Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8845-54. PMID 24966384 DOI: 10.1523/Jneurosci.4027-13.2014  0.601
2014 Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nature Reviews. Immunology. 14: 463-77. PMID 24962261 DOI: 10.1038/Nri3705  0.535
2014 Brosseron F, Krauthausen M, Kummer M, Heneka MT. Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview. Molecular Neurobiology. 50: 534-44. PMID 24567119 DOI: 10.1007/S12035-014-8657-1  0.589
2014 Brosseron F, Kummer MP, Krauthausen M, Jessen F, Heneka M. Correlation Of Cerebrospinal Fluid Cytokines With Clinical Markers Of Dementia In Mild Cognitive Impairment And Alzheimer'S Disease Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.786  0.54
2014 Wijasa TS, Brosseron F, Kummer MP, Heneka M. Nitro-Proteomics To Discover Synaptosomal Biomarkers Of Neuroinflammation In Alzheimer'S Disease Alzheimers & Dementia. 10: 360. DOI: 10.1016/J.Jalz.2014.05.402  0.569
2013 Chalermpalanupap T, Kinkead B, Hu WT, Kummer MP, Hammerschmidt T, Heneka MT, Weinshenker D, Levey AI. Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease. Alzheimer's Research & Therapy. 5: 21. PMID 23634965 DOI: 10.1186/Alzrt175  0.619
2013 Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 493: 674-8. PMID 23254930 DOI: 10.1038/Nature11729  0.647
2013 Hammerschmidt T, Kummer MP, Terwel D, Martinez A, Gorji A, Pape HC, Rommelfanger KS, Schroeder JP, Stoll M, Schultze J, Weinshenker D, Heneka MT. Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice. Biological Psychiatry. 73: 454-63. PMID 22883210 DOI: 10.1016/J.Biopsych.2012.06.013  0.622
2013 Rapic S, Backes H, Viel T, Kummer MP, Monfared P, Neumaier B, Vollmar S, Hoehn M, Van der Linden A, Heneka MT, Jacobs AH. Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. Neurobiology of Aging. 34: 351-4. PMID 22651996 DOI: 10.1016/J.Neurobiolaging.2012.04.016  0.591
2013 Delgado-Morales R, Patchev A, Llobet-Navas D, Kummer M, Heneka M, Silva J, Almeida O. Delay of Alzheimer's-like pathology in mice with 7,8-dihydroxyflavone Alzheimers & Dementia. 9: 815. DOI: 10.1016/J.Jalz.2013.05.1747  0.582
2012 Kummer MP, Vogl T, Axt D, Griep A, Vieira-Saecker A, Jessen F, Gelpi E, Roth J, Heneka MT. Mrp14 deficiency ameliorates amyloid β burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17824-9. PMID 23223301 DOI: 10.1523/Jneurosci.1504-12.2012  0.672
2012 Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT. PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17321-31. PMID 23197723 DOI: 10.1523/Jneurosci.1569-12.2012  0.642
2012 Kummer MP, Hülsmann C, Hermes M, Axt D, Heneka MT. Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 165-72. PMID 22227962 DOI: 10.1007/S11481-011-9339-7  0.562
2012 Rey NL, Jardanhazi-Kurutz D, Terwel D, Kummer MP, Jourdan F, Didier A, Heneka MT. Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice. Neurobiology of Aging. 33: 426.e1-11. PMID 21109328 DOI: 10.1016/J.Neurobiolaging.2010.10.009  0.543
2012 Kummer M. Nitration of amyloid β in Alzheimer’s disease Nitric Oxide. 27. DOI: 10.1016/J.Niox.2012.04.013  0.53
2011 Heneka MT, Reyes-Irisarri E, Hüll M, Kummer MP. Impact and Therapeutic Potential of PPARs in Alzheimer's Disease. Current Neuropharmacology. 9: 643-50. PMID 22654722 DOI: 10.2174/157015911798376325  0.642
2011 Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT. Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron. 71: 833-44. PMID 21903077 DOI: 10.1016/J.Neuron.2011.07.001  0.666
2011 Mildner A, Schlevogt B, Kierdorf K, Böttcher C, Erny D, Kummer MP, Quinn M, Brück W, Bechmann I, Heneka MT, Priller J, Prinz M. Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11159-71. PMID 21813677 DOI: 10.1523/Jneurosci.6209-10.2011  0.649
2011 Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Kummer MP, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/J.Jalz.2011.05.2243  0.551
2011 Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7049-59. PMID 21562267 DOI: 10.1523/Jneurosci.6546-10.2011  0.639
2011 Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU. Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Current Alzheimer Research. 8: 115-31. PMID 21345168 DOI: 10.2174/156720511795256099  0.778
2011 Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT. Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience. 176: 396-407. PMID 21129451 DOI: 10.1016/J.Neuroscience.2010.11.052  0.605
2011 Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D, Leza JC, Heneka MT. Restraint stress increases neuroinflammation independently of amyloid β levels in amyloid precursor protein/PS1 transgenic mice. Journal of Neurochemistry. 116: 43-52. PMID 21044080 DOI: 10.1111/J.1471-4159.2010.07083.X  0.595
2010 Fleisher-Berkovich S, Filipovich-Rimon T, Ben-Shmuel S, Hülsmann C, Kummer MP, Heneka MT. Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides (i). Journal of Neuroinflammation. 7: 61. PMID 20937084 DOI: 10.1186/1742-2094-7-61  0.54
2010 Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 919-47. PMID 20632195 DOI: 10.1007/S00702-010-0438-Z  0.647
2010 Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP. Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proceedings of the National Academy of Sciences of the United States of America. 107: 6058-63. PMID 20231476 DOI: 10.1073/Pnas.0909586107  0.648
2010 Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT. Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochemistry International. 57: 375-82. PMID 20144675 DOI: 10.1016/J.Neuint.2010.02.001  0.618
2009 Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14177-84. PMID 19906966 DOI: 10.1523/Jneurosci.3238-09.2009  0.515
2009 Papi A, Tatenhorst L, Terwel D, Hermes M, Kummer MP, Orlandi M, Heneka MT. PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. Journal of Neurochemistry. 109: 1779-90. PMID 19457135 DOI: 10.1111/J.1471-4159.2009.06111.X  0.487
2009 Kummer MP, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo EH. Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. The Journal of Biological Chemistry. 284: 2296-306. PMID 19047044 DOI: 10.1074/Jbc.M808904200  0.73
2009 Heneka MT, Nadrigny F, Regen T, Dumitrescu-Ozimek L, Jardanhazi-Kurutz D, Terwel D, Walter J, Hanisch UK, Kirchhoff F, Kummer MP. O4-02-06: Norepinephrine modulates salutary microglial functions in transgenic models of Alzheimer's disease Alzheimer's & Dementia. 5: P153-P153. DOI: 10.1016/J.Jalz.2009.05.527  0.553
2009 Kummer MP, Hermes M, Hammerschmidt T, Terwel D, Gorji A, Pape H, Heneka MT. O1-05-07: iNOS gene deficiency modifies amyloid β deposition, cognitive performance and hippocampal long-term potentiation in an APP transgenic mouse model Alzheimer's & Dementia. 5: P89-P89. DOI: 10.1016/J.Jalz.2009.05.229  0.54
2009 Hammerschmidt T, Terwel D, Kummer M, Weinshenker D, Gorji A, Hermann S, Schäfers M, Pape H, Heneka MT. P4-235: Norepinephrine deficiency aggravates learning and memory impairment independent of amyloid-beta levels in APP PS1 mice Alzheimer's & Dementia. 5: P499-P499. DOI: 10.1016/J.Jalz.2009.04.701  0.539
2008 Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Schäfers M, Kummer MP, Klockgether T, Heneka MT. Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. Journal of Neuroinflammation. 5: 38. PMID 18793399 DOI: 10.1186/1742-2094-5-38  0.487
2008 Kummer MP, Heneka MT. PPARs in Alzheimer's Disease. Ppar Research. 2008: 403896. PMID 18645613 DOI: 10.1155/2008/403896  0.646
2006 Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH. Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1254-6. PMID 16636103 DOI: 10.1096/Fj.05-5032Fje  0.704
2006 Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/J.1471-4159.2005.03553.X  0.764
2004 Schmitz A, Schneider A, Kummer MP, Herzog V. Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways. Traffic (Copenhagen, Denmark). 5: 89-101. PMID 14690498 DOI: 10.1111/J.1600-0854.2004.00159.X  0.616
2004 Weggen S, Berdeaux R, Kummer MP, Birkenfeld J, Sagi SS, Golde TE, Koo EH. P4-380 Inhibitors of the RHO effector RHO-kinase (rock) modulate Aβ secretion but lack selectivity for Aβ42 Neurobiology of Aging. 25: S583. DOI: 10.1016/S0197-4580(04)81938-9  0.703
2004 Kummer MP, Koo EH. P4-200 Phosphorylated C-terminal fragments of the Alzheimer precursor protein are present in caveolin-rich membrane fractions Neurobiology of Aging. 25: S532. DOI: 10.1016/S0197-4580(04)81758-5  0.547
2000 Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P, Herzog V. A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation. European Journal of Cell Biology. 79: 905-14. PMID 11152291 DOI: 10.1078/0171-9335-00117  0.61
2000 Hitzel C, Kanzler H, König A, Kummer MP, Brix K, Herzog V, Koch N. Thyroglobulin type-I-like domains in invariant chain fusion proteins mediate resistance to cathepsin L digestion. Febs Letters. 485: 67-70. PMID 11086167 DOI: 10.1016/S0014-5793(00)02189-X  0.506
1999 Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, Herzog V. Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 47: 373-82. PMID 10026239 DOI: 10.1177/002215549904700311  0.681
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