Phil Skolnick, Ph.D., D.Sc. (hon.) - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
anxiolytic drugs, GABA Receptors, glutamate, benzodiazepines, antidepressants, NMDA receptor

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Year Citation  Score
2019 Krieter P, Gyaw S, Chiang CN, Crystal R, Skolnick P. Enhanced Intranasal Absorption of Naltrexone by Dodecyl Maltopyranoside: Implications for the Treatment of Opioid Overdose. Journal of Clinical Pharmacology. PMID 30698833 DOI: 10.1002/jcph.1384  0.36
2016 Bespalov A, Steckler T, Altevogt B, Koustova E, Skolnick P, Deaver D, Millan MJ, Bastlund JF, Doller D, Witkin J, Moser P, O'Donnell P, Ebert U, Geyer MA, Prinssen E, et al. Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets. Nature Reviews. Drug Discovery. PMID 27312728 DOI: 10.1038/nrd.2016.88  0.44
2016 Krieter P, Chiang N, Gyaw S, Skolnick P, Crystal R, Keegan F, Aker J, Beck M, Harris J. Pharmacokinetic Properties and Human Use Characteristics of an FDA Approved Intranasal Naloxone Product for the Treatment of Opioid Overdose. Journal of Clinical Pharmacology. PMID 27145977 DOI: 10.1002/jcph.759  1
2015 Skolnick P. Biologic Approaches to Treat Substance-Use Disorders. Trends in Pharmacological Sciences. 36: 628-35. PMID 26435208 DOI: 10.1016/j.tips.2015.07.002  1
2015 Skolnick P, Kos T, Czekaj J, Popik P. Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test. Acta Neuropsychiatrica. 27: 228-34. PMID 25858023 DOI: 10.1017/neu.2015.14  1
2015 Popik P, Holuj M, Nikiforuk A, Kos T, Trullas R, Skolnick P. 1-aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats. Psychopharmacology. 232: 1025-38. PMID 25260339 DOI: 10.1007/s00213-014-3738-4  1
2015 Skolnick P, White D, Acri JB. Emerging targets for stimulant use disorders: Where to invest in an era of constrained resources? Cns and Neurological Disorders - Drug Targets. 14: 691.  1
2015 Skolnick P, White D, Acri JB. Synopsis of expert opinions and conclusions Cns and Neurological Disorders - Drug Targets. 14: 773-776.  1
2014 Skolnick P, Davis H, Arnelle D, Deaver D. Translational potential of naloxone and naltrexone as TLR4 antagonists. Trends in Pharmacological Sciences. 35: 431-2. PMID 25109569 DOI: 10.1016/j.tips.2014.06.008  1
2014 Kim SW, Fowler JS, Skolnick P, Muench L, Kang Y, Shea C, Logan J, Kim D, Carter P, King P, Alexoff D, Volkow ND. Therapeutic doses of buspirone block D3 receptors in the living primate brain. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 1257-67. PMID 24679922 DOI: 10.1017/S1461145714000194  1
2013 Pilc A, WieroÅ„ska JM, Skolnick P. Glutamate-based antidepressants: preclinical psychopharmacology. Biological Psychiatry. 73: 1125-32. PMID 23453290 DOI: 10.1016/j.biopsych.2013.01.021  1
2013 Skolnick P. Response to W. Sieghart. Trends in Pharmacological Sciences. 34: 146. PMID 23384390 DOI: 10.1016/j.tips.2013.01.007  1
2013 Bergman J, Roof RA, Furman CA, Conroy JL, Mello NK, Sibley DR, Skolnick P. Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 445-58. PMID 22827916 DOI: 10.1017/S1461145712000661  1
2012 Skolnick P, Volkow ND. Addiction therapeutics: obstacles and opportunities. Biological Psychiatry. 72: 890-1. PMID 23121867 DOI: 10.1016/j.biopsych.2012.08.004  1
2012 Skolnick P. Anxioselective anxiolytics: on a quest for the Holy Grail. Trends in Pharmacological Sciences. 33: 611-20. PMID 22981367 DOI: 10.1016/j.tips.2012.08.003  1
2012 Warnock KT, Yang AR, Yi HS, June HL, Kelly T, Basile AS, Skolnick P, June HL. Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology. Pharmacology, Biochemistry, and Behavior. 103: 111-8. PMID 22884707 DOI: 10.1016/j.pbb.2012.07.014  1
2012 Newman AH, Blaylock BL, Nader MA, Bergman J, Sibley DR, Skolnick P. Medication discovery for addiction: translating the dopamine D3 receptor hypothesis. Biochemical Pharmacology. 84: 882-90. PMID 22781742 DOI: 10.1016/j.bcp.2012.06.023  1
2012 Volkow ND, Skolnick P. New medications for substance use disorders: challenges and opportunities. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 290-2. PMID 22157859 DOI: 10.1038/npp.2011.84  1
2012 Yang AR, Yi HS, Warnock KT, Mamczarz J, June HL, Mallick N, Krieter PA, Tonelli L, Skolnick P, Basile AS, June HL. Effects of the triple monoamine uptake inhibitor DOV 102,677 on alcohol-motivated responding and antidepressant activity in alcohol-preferring (P) rats. Alcoholism, Clinical and Experimental Research. 36: 863-73. PMID 22150508 DOI: 10.1111/j.1530-0277.2011.01671.x  1
2012 Tran P, Skolnick P, Czobor P, Huang NY, Bradshaw M, McKinney A, Fava M. Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial. Journal of Psychiatric Research. 46: 64-71. PMID 21925682 DOI: 10.1016/j.jpsychires.2011.09.003  1
2012 Lindholm JS, Autio H, Vesa L, Antila H, Lindemann L, Hoener MC, Skolnick P, Rantamäki T, Castrén E. The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf⁺/⁻ heterozygous null mice. Neuropharmacology. 62: 391-7. PMID 21867718 DOI: 10.1016/j.neuropharm.2011.08.015  1
2012 Tran P, Skolnick P, Czobor P, Huang NY, Bradshaw M, McKinney A, Fava M. Response to Marks, Abramowitz, and Spielmans Letter to the Editor Journal of Psychiatric Research. 46: 694-695. DOI: 10.1016/j.jpsychires.2012.02.001  1
2012 Skolnick P. Triple-Uptake Inhibitors (Broad-Spectrum Antidepressants) Polypharmacology in Drug Discovery. 363-382. DOI: 10.1002/9781118098141.ch18  1
2011 Skolnick P, Volkow ND. Editorial: magic bullets and arrows: biologic approaches to treat substance use disorders. Cns & Neurological Disorders Drug Targets. 10: 864. PMID 22229309  1
2011 Czobor P, Skolnick P. The secrets of a successful clinical trial: compliance, compliance, and compliance. Molecular Interventions. 11: 107-10. PMID 21540470 DOI: 10.1124/mi.11.2.8  1
2010 Czobor P, Skolnick P, Beer B, Lippa A. A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder. Cns Neuroscience & Therapeutics. 16: 63-75. PMID 20041911 DOI: 10.1111/j.1755-5949.2009.00109.x  1
2010 Skolnick P, Popik P, Trullas R. N-methyl-D-aspartate (NMDA) antagonists for the treatment of depression Milestones in Drug Therapy. 1-20. DOI: 10.1007/978-3-0346-0241-9_1  1
2009 Skolnick P, Popik P, Trullas R. Glutamate-based antidepressants: 20 years on. Trends in Pharmacological Sciences. 30: 563-9. PMID 19837463 DOI: 10.1016/j.tips.2009.09.002  1
2009 Nicholson KL, Balster RL, Golembiowska K, Kowalska M, Tizzano JP, Skolnick P, Basile AS. Preclinical evaluation of the abuse potential of the analgesic bicifadine. The Journal of Pharmacology and Experimental Therapeutics. 330: 236-48. PMID 19357320 DOI: 10.1124/jpet.109.150540  1
2009 Chen Z, Yang J, Skolnick P. The design, synthesis and structure-activity relationship of mixed serotonin, norepinephrine and dopamine uptake inhibitors Topics in Medicinal Chemistry. 4: 131-154. DOI: 10.1007/7355_2007_016  1
2008 Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. Bmc Pharmacology. 8: 11. PMID 18554397 DOI: 10.1186/1471-2210-8-11  1
2008 Skolnick P. AMPA receptors: a target for novel antidepressants? Biological Psychiatry. 63: 347-8. PMID 18237615 DOI: 10.1016/j.biopsych.2007.10.011  1
2008 Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS. The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of Pharmacology and Experimental Therapeutics. 324: 1111-26. PMID 18089843 DOI: 10.1124/jpet.107.133132  1
2007 Chen Z, Skolnick P. Triple uptake inhibitors: therapeutic potential in depression and beyond. Expert Opinion On Investigational Drugs. 16: 1365-77. PMID 17714023 DOI: 10.1517/13543784.16.9.1365  1
2007 Skolnick P, Basile AS. Triple reuptake inhibitors ("broad spectrum" antidepressants). Cns & Neurological Disorders Drug Targets. 6: 141-9. PMID 17430151 DOI: 10.2174/187152707780363285  1
2007 Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E. Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. The Journal of Pharmacology and Experimental Therapeutics. 321: 1208-25. PMID 17325229 DOI: 10.1124/jpet.106.116483  1
2006 Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. The Journal of Pharmacology and Experimental Therapeutics. 319: 1244-52. PMID 16971504 DOI: 10.1124/jpet.106.107201  1
2006 Skolnick P, Krieter P, Tizzano J, Basile A, Popik P, Czobor P, Lippa A. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. Cns Drug Reviews. 12: 123-34. PMID 16958986 DOI: 10.1111/j.1527-3458.2006.00123.x  1
2006 Popik P, Krawczyk M, Golembiowska K, Nowak G, Janowsky A, Skolnick P, Lippa A, Basile AS. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and Molecular Neurobiology. 26: 857-73. PMID 16636898 DOI: 10.1007/s10571-006-9012-5  1
2006 Skolnick P, Basile AS. Triple reuptake inhibitors as antidepressants Drug Discovery Today: Therapeutic Strategies. 3: 489-494. DOI: 10.1016/j.ddstr.2006.10.010  1
2006 Basile AS, Lippa AS, Skolnick P. GABAA receptor modulators as anxioselective anxiolytics Drug Discovery Today: Therapeutic Strategies. 3: 475-481. DOI: 10.1016/j.ddstr.2006.10.009  1
2005 Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proceedings of the National Academy of Sciences of the United States of America. 102: 7380-5. PMID 15870187 DOI: 10.1073/pnas.0502579102  1
2005 Skolnick P. Dopamine and depression Dopamine and Glutamate in Psychiatric Disorders. 199-214. DOI: 10.1007/978-1-59259-852-6_9  1
2004 Beer B, Stark J, Krieter P, Czobor P, Beer G, Lippa A, Skolnick P. DOV 216,303, a "triple" reuptake inhibitor: safety, tolerability, and pharmacokinetic profile. Journal of Clinical Pharmacology. 44: 1360-7. PMID 15545306 DOI: 10.1177/0091270004269560  1
2004 Basile AS, Lippa AS, Skolnick P. Anxioselective anxiolytics: can less be more? European Journal of Pharmacology. 500: 441-51. PMID 15464051 DOI: 10.1016/j.ejphar.2004.07.043  1
2004 O'Neill MJ, Murray TK, Whalley K, Ward MA, Hicks CA, Woodhouse S, Osborne DJ, Skolnick P. Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease. European Journal of Pharmacology. 486: 163-74. PMID 14975705 DOI: 10.1016/j.ejphar.2003.12.023  1
2003 Paul IA, Skolnick P. Glutamate and depression: clinical and preclinical studies. Annals of the New York Academy of Sciences. 1003: 250-72. PMID 14684451 DOI: 10.1196/annals.1300.016  1
2003 Skolnick P, Popik P, Janowsky A, Beer B, Lippa AS. "Broad spectrum" antidepressants: is more better for the treatment of depression? Life Sciences. 73: 3175-9. PMID 14561522 DOI: 10.1016/j.lfs.2003.06.007  1
2003 June HL, Foster KL, McKay PF, Seyoum R, Woods JE, Harvey SC, Eiler WJ, Grey C, Carroll MR, McCane S, Jones CM, Yin W, Mason D, Cummings R, Garcia M, ... ... Skolnick P, et al. The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2124-37. PMID 12968126 DOI: 10.1038/sj.npp.1300239  1
2003 Li X, Witkin JM, Need AB, Skolnick P. Enhancement of antidepressant potency by a potentiator of AMPA receptors. Cellular and Molecular Neurobiology. 23: 419-30. PMID 12825836 DOI: 10.1023/A:1023648923447  1
2003 Murray TK, Whalley K, Robinson CS, Ward MA, Hicks CA, Lodge D, Vandergriff JL, Baumbarger P, Siuda E, Gates M, Ogden AM, Skolnick P, Zimmerman DM, Nisenbaum ES, Bleakman D, et al. LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 306: 752-62. PMID 12730350 DOI: 10.1124/jpet.103.049445  1
2003 Skolnick P, Popik P, Janowsky A, Beer B, Lippa AS. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. European Journal of Pharmacology. 461: 99-104. PMID 12586204 DOI: 10.1016/S0014-2999(03)01310-4  1
2002 Skolnick P. Beyond monoamine-based therapies: clues to new approaches. The Journal of Clinical Psychiatry. 63: 19-23. PMID 15453010  1
2002 Quirk JC, Linden AM, Strakhova M, Yu H, Skolnick P, Nisenbaum ES. A single residue contributes sensitivity to allosteric modulation of AMPA receptors by LY395153. European Journal of Pharmacology. 454: 125-9. PMID 12421639 DOI: 10.1016/S0014-2999(02)02491-3  1
2002 Skolnick P. Modulation of glutamate receptors: strategies for the development of novel antidepressants. Amino Acids. 23: 153-9. PMID 12373530 DOI: 10.1007/s00726-001-0121-7  1
2002 Mackowiak M, O'Neill MJ, Hicks CA, Bleakman D, Skolnick P. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. 43: 1-10. PMID 12213254 DOI: 10.1016/S0028-3908(02)00066-7  1
2001 Bai F, Li X, Clay M, Lindstrom T, Skolnick P. Intra- and interstrain differences in models of "behavioral despair". Pharmacology, Biochemistry, and Behavior. 70: 187-92. PMID 11701187 DOI: 10.1016/S0091-3057(01)00599-8  1
2001 Harvey SC, Köster A, Yu H, Skolnick P, Baumbarger P, Nisenbaum ES. AMPA receptor function is altered in GLUR2-deficient mice. Journal of Molecular Neuroscience : Mn. 17: 35-43. PMID 11665861 DOI: 10.1385/JMN:17:1:35  1
2001 Zarrinmayeh H, Bleakman D, Gates MR, Yu H, Zimmerman DM, Ornstein PL, McKennon T, Arnold MB, Wheeler WJ, Skolnick P. [3H]N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide: a novel AMPA receptor potentiator and radioligand. Journal of Medicinal Chemistry. 44: 302-4. PMID 11462971 DOI: 10.1021/jm000462n  1
2001 Li X, Tizzano JP, Griffey K, Clay M, Lindstrom T, Skolnick P. Antidepressant-like actions of an AMPA receptor potentiator (LY392098). Neuropharmacology. 40: 1028-33. PMID 11406194 DOI: 10.1016/S0028-3908(00)00194-5  1
2001 Legutko B, Li X, Skolnick P. Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator. Neuropharmacology. 40: 1019-27. PMID 11406193 DOI: 10.1016/S0028-3908(01)00006-5  1
2001 Lindén AM, Yu H, Zarrinmayeh H, Wheeler WJ, Skolnick P. Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors. Neuropharmacology. 40: 1010-8. PMID 11406192 DOI: 10.1016/S0028-3908(01)00013-2  1
2001 Skolnick P, Legutko B, Li X, Bymaster FP. Current perspectives on the development of non-biogenic amine-based antidepressants. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 43: 411-23. PMID 11394932 DOI: 10.1006/phrs.2000.0806  1
2001 Strakhova MI, Skolnick P. Can 'differential display' methodologies make an impact on biological psychiatry? The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 4: 75-82. PMID 11343632 DOI: doi:10.1017/S1461145701002243  1
2001 Skolnick P. Chapter 3 Ibogaine as a glutamate antagonist: Relevance to its putative antiaddictive properties Alkaloids: Chemistry and Biology. 56: 55-62.  1
2000 Strakhova MI, Harvey SC, Cook CM, Cook JM, Skolnick P. A single amino acid residue on the alpha(5) subunit (Ile215) is essential for ligand selectivity at alpha(5)beta(3)gamma(2) gamma-aminobutyric acid(A) receptors. Molecular Pharmacology. 58: 1434-40. PMID 11093783  1
2000 Viu E, Zapata A, Capdevila J, Skolnick P, Trullas R. Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning. Neurobiology of Learning and Memory. 74: 146-60. PMID 10933900 DOI: 10.1006/nlme.1999.3947  1
2000 Harvey SC, Li X, Skolnick P, Kirst HA. The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable. European Journal of Pharmacology. 387: 1-7. PMID 10633153 DOI: 10.1016/S0014-2999(99)00798-0  1
2000 Segal JA, Skolnick P. Spermine-induced toxicity in cerebellar granule neurons is independent of its actions at NMDA receptors. Journal of Neurochemistry. 74: 60-9. PMID 10617106 DOI: 10.1046/j.1471-4159.2000.0740060.x  1
1999 Hoo K, Legutko B, Rizkalla G, Deverill M, Hawes CR, Ellis GJ, Stensbol TB, Krogsgaard-Larsen P, Skolnick P, Bleakman D. [3H]ATPA: a high affinity ligand for GluR5 kainate receptors. Neuropharmacology. 38: 1811-7. PMID 10608276 DOI: 10.1016/S0028-3908(99)00133-1  1
1999 Nahum-Levy R, Fossom LH, Skolnick P, Benveniste M. Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors. Molecular Pharmacology. 56: 1207-18. PMID 10570048  1
1999 Harvey SC, Skolnick P. Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors. The Journal of Pharmacology and Experimental Therapeutics. 291: 285-91. PMID 10490915  1
1999 Skolnick P. Antidepressants for the new millennium. European Journal of Pharmacology. 375: 31-40. PMID 10443562 DOI: 10.1016/S0014-2999(99)00330-1  1
1999 Basile AS, Brichta AM, Harris BD, Morse D, Coling D, Skolnick P. Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats. Neuroscience Letters. 265: 71-4. PMID 10327171 DOI: 10.1016/S0304-3940(99)00050-6  1
1999 Segal JA, Harris BD, Kustova Y, Basile A, Skolnick P. Aminoglycoside neurotoxicity involves NMDA receptor activation. Brain Research. 815: 270-7. PMID 9878779 DOI: 10.1016/S0006-8993(98)01123-8  1
1999 Harris BD, Segal JA, Kustova Y, Basile A, Skolnick P. Aminoglycoside neurotoxicity involves N-methyl-D-aspartate receptor activation Critical Care Medicine. 27: A104.  1
1998 Moody EJ, Knauer CS, Granja R, Strakhovaua M, Skolnick P. Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABA(A) receptors. Toxicology Letters. 100: 209-15. PMID 10049144 DOI: 10.1016/S0378-4274(98)00187-8  1
1998 Lin Y, Fossom LH, Skolnick P, Long JB. Sustained exposure to a glycine receptor partial agonist differentially alters NMDA receptor agonist and antagonist potencies in cultured spinal cord neurons. European Journal of Pharmacology. 356: 255-60. PMID 9774257 DOI: 10.1016/S0014-2999(98)00515-9  1
1998 Boyer PA, Skolnick P, Fossom LH. Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain. A quantitative in situ hybridization study. Journal of Molecular Neuroscience : Mn. 10: 219-33. PMID 9770644 DOI: 10.1007/BF02761776  1
1998 Valeyev AY, Schaffner AE, Skolnick P, Dunlap VS, Wong G, Barker JL. Embryonic rat hippocampal neurons and GABAA receptor subunit-transfected non-neuronal cells release GABA tonically. The Journal of Membrane Biology. 164: 239-51. PMID 9691117 DOI: 10.1007/s002329900409  1
1998 Segal JA, Skolnick P. Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors. European Journal of Pharmacology. 347: 311-7. PMID 9653898 DOI: 10.1016/S0014-2999(98)00108-3  1
1998 Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM. Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. Journal of Medicinal Chemistry. 41: 2537-52. PMID 9651158 DOI: 10.1021/jm970460b  1
1998 Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacological Reviews. 50: 291-313. PMID 9647870  1
1998 Sei Y, Kustova Y, Li Y, Morse HC, Skolnick P, Basile AS. The encephalopathy associated with murine acquired immunodeficiency syndrome. Annals of the New York Academy of Sciences. 840: 822-34. PMID 9629308 DOI: 10.1111/j.1749-6632.1998.tb09620.x  1
1998 Granja R, Strakhova M, Knauer CS, Skolnick P. Anomalous rectifying properties of 'diazepam-insensitive' GABA(A) receptors. European Journal of Pharmacology. 345: 315-21. PMID 9592032 DOI: 10.1016/S0014-2999(98)00025-9  1
1998 Viu E, Zapata A, Capdevila JL, Fossom LH, Skolnick P, Trullas R. Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells. The Journal of Pharmacology and Experimental Therapeutics. 285: 527-32. PMID 9580593  1
1998 Nowak G, Legutko B, Skolnick P, Popik P. Adaptation of cortical NMDA receptors by chronic treatment with specific serotonin reuptake inhibitors. European Journal of Pharmacology. 342: 367-70. PMID 9548410 DOI: 10.1016/S0014-2999(97)01589-6  1
1998 Harris BD, Moody EJ, Skolnick P. Stereoselective actions of halothane at GABA(A) receptors. European Journal of Pharmacology. 341: 349-52. PMID 9543259 DOI: 10.1016/S0014-2999(97)01488-X  1
1998 Lewin AH, Sun G, Fudala L, Navarro H, Zhou LM, Popik P, Faynsteyn A, Skolnick P. Molecular features associated with polyamine modulation of NMDA receptors. Journal of Medicinal Chemistry. 41: 988-95. PMID 9526573 DOI: 10.1021/jm9707129  1
1998 Sei Y, Fossom L, Goping G, Skolnick P, Basile AS. Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis. Neuroscience Letters. 241: 180-4. PMID 9507950 DOI: 10.1016/S0304-3940(97)00980-4  1
1998 Popik P, Skolnick P. Chapter 3 Pharmacology of Ibogaine And Ibogaine-Related Alkaloids Alkaloids: Chemistry and Biology. 52: 197-231. DOI: 10.1016/S0099-9598(08)60027-9  1
1997 Granja R, Gunnersen D, Wong G, Valeyev A, Skolnick P. Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors: relationship to benzodiazepine binding site density. Journal of Molecular Neuroscience : Mn. 9: 187-95. PMID 9481620 DOI: 10.1007/BF02800501  1
1997 Huang NY, Strakhova M, Layer RT, Skolnick P. Chronic antidepressant treatments increase cytochrome b mRNA levels in mouse cerebral cortex. Journal of Molecular Neuroscience : Mn. 9: 167-76. PMID 9481618 DOI: 10.1007/BF02800499  1
1997 Bovetto S, Boyer P, Skolnick P, Fossom LH. Chronic administration of a glycine partial agonist alters the expression of N-methyl-D-aspartate receptor subunit mRNAs. The Journal of Pharmacology and Experimental Therapeutics. 283: 1503-8. PMID 9400027  1
1997 Skolnick P, Hu RJ, Cook CM, Hurt SD, Trometer JD, Liu R, Huang Q, Cook JM. [3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits. The Journal of Pharmacology and Experimental Therapeutics. 283: 488-93. PMID 9353361  1
1997 Moody EJ, Knauer C, Granja R, Strakhova M, Skolnick P. Distinct loci mediate the direct and indirect actions of the anesthetic etomidate at GABA(A) receptors. Journal of Neurochemistry. 69: 1310-3. PMID 9282957  1
1997 Fossom LH, Skolnick P. Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias. Journal of Neural Transmission. Supplementum. 49: 235-44. PMID 9266432  1
1997 Zhou LM, Gu ZQ, Costa AM, Yamada KA, Mansson PE, Giordano T, Skolnick P, Jones KA. (2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors. The Journal of Pharmacology and Experimental Therapeutics. 280: 422-7. PMID 8996224  1
1997 Laszlo O, Bokonyi G, Szendrei GI, Varga I, Vasko M, Zhou LM, Skolnick P, Maccecchini ML. The flexible termini of conantokin G define its interactions with NMDA receptors International Journal of Peptide Research and Therapeutics. 4: 85-93.  1
1996 Gunnersen D, Kaufman CM, Skolnick P. Pharmacological properties of recombinant "diazepam-insensitive" GABAA receptors. Neuropharmacology. 35: 1307-14. PMID 9014146 DOI: 10.1016/S0028-3908(96)00054-8  1
1996 Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P. N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nature Medicine. 2: 1338-43. PMID 8946832 DOI: 10.1038/nm1296-1338  1
1996 Layer RT, Skolnick P, Bertha CM, Bandarage UK, Kuehne ME, Popik P. Structurally modified ibogaine analogs exhibit differing affinities for NMDA receptors. European Journal of Pharmacology. 309: 159-65. PMID 8874134 DOI: 10.1016/0014-2999(96)00304-4  1
1996 Maity R, Mukherjee R, Skolnick P. Stereoselective inhibition of natural killer activity by the sigma ligand (+)-pentazocine. Journal of Neuroimmunology. 70: 7-13. PMID 8862129 DOI: 10.1016/S0165-5728(96)00046-X  1
1996 Skolnick P, Layer RT, Popik P, Nowak G, Paul IA, Trullas R. Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry. 29: 23-6. PMID 8852530 DOI: 10.1055/s-2007-979537  1
1996 Popik P, Skolnick P. The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence. Pharmacology, Biochemistry, and Behavior. 53: 791-7. PMID 8801580 DOI: 10.1016/0091-3057(95)02163-9  1
1996 Sei Y, Whitesell L, Kustova Y, Paul IA, Morse HC, Skolnick P, Basile AS. Altered brain fyn kinase in a murine acquired immunodeficiency syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 339-44. PMID 8641568  1
1996 Liu R, Hu RJ, Zhang P, Skolnick P, Cook JM. Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. Journal of Medicinal Chemistry. 39: 1928-34. PMID 8627617 DOI: 10.1021/jm950887n  1
1996 Zhou LM, Szendrei GI, Fossom LH, Maccecchini ML, Skolnick P, Otvos L. Synthetic analogues of conantokin-G: NMDA antagonists acting through a novel polyamine-coupled site. Journal of Neurochemistry. 66: 620-8. PMID 8592132  1
1996 Nishida K, Markey SP, Kustova Y, Morse HC, Skolnick P, Basile AS, Sei Y. Increased brain levels of platelet-activating factor in a murine acquired immune deficiency syndrome are NMDA receptor-mediated. Journal of Neurochemistry. 66: 433-5. PMID 8522986  1
1996 Sei Y, Paul IA, Saito K, Layar R, Hartley JW, Morse HC, Skolnick P, Heyes MP. Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome. Journal of Neurochemistry. 66: 296-302. PMID 8522967  1
1995 Fossom LH, Basile AS, Skolnick P. Sustained exposure to 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition. Molecular Pharmacology. 48: 981-7. PMID 8848014  1
1995 Popik P, Lewin A, Berrang B, Nowak G, Layer R, Skolnick P. [3H]1-aminocyclopropanecarboxylic acid, a novel probe for strychnine- insensitive glycine receptors. European Journal of Pharmacology. 291: 221-7. PMID 8719405 DOI: 10.1016/0922-4106(95)90061-6  1
1995 Layer RT, Popik P, Olds T, Skolnick P. Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715). Pharmacology, Biochemistry, and Behavior. 52: 621-7. PMID 8545484 DOI: 10.1016/0091-3057(95)00155-P  1
1995 Zhou LM, He XS, Li G, de Costa BR, Skolnick P. Synthesis of N,N'-substituted piperazine and homopiperazine derivatives with polyamine-like actions at N-methyl-D-aspartate receptors. Journal of Medicinal Chemistry. 38: 4891-6. PMID 8523402  1
1995 Harris BD, Wong G, Moody EJ, Skolnick P. Different subunit requirements for volatile and nonvolatile anesthetics at gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 47: 363-7. PMID 7870045  1
1995 Sei Y, Takemura M, Gusovsky F, Skolnick P, Basile A. Distinct mechanisms for Ca2+ entry induced by OKT3 and Ca2+ depletion in Jurkat T cells. Experimental Cell Research. 216: 222-31. PMID 7813624 DOI: 10.1006/excr.1995.1028  1
1995 Maity R, Mukherjee R, Skolnick P. Morphine inhibits the development of allogeneic immune responses in mouse lymph node. Immunopharmacology. 29: 175-83. PMID 7775160 DOI: 10.1016/0162-3109(94)00058-N  1
1995 Zhang P, Zhang W, Liu R, Harris B, Skolnick P, Cook JM. Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors. Journal of Medicinal Chemistry. 38: 1679-88. PMID 7752192  1
1995 Wang CG, Langer T, Kamath PG, Gu ZQ, Skolnick P, Fryer RI. Computer-aided molecular modeling, synthesis, and biological evaluation of 8-(benzyloxy)-2-phenylpyrazolo[4,3-c]quinoline as a novel benzodiazepine receptor agonist ligand. Journal of Medicinal Chemistry. 38: 950-7. PMID 7699711  1
1995 Gu ZQ, Hesson DP, Pelletier JC, Maccecchini ML, Zhou LM, Skolnick P. Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors. Journal of Medicinal Chemistry. 38: 2518-20. PMID 7629789  1
1995 Popik P, Layer RT, Skolnick P. 100 years of ibogaine: neurochemical and pharmacological actions of a putative anti-addictive drug. Pharmacological Reviews. 47: 235-53. PMID 7568327  1
1995 Harris BD, Moody EJ, Gu ZQ, Skolnick P. Contribution of "diazepam-insensitive" GABAA receptors to the alcohol antagonist properties of Ro 15-4513 and related imidazobenzodiazepines. Pharmacology, Biochemistry, and Behavior. 52: 113-8. PMID 7501652 DOI: 10.1016/0091-3057(95)00052-X  1
1995 Fossom LH, Skolnick P. Sensitization and desensitization of the NMDA receptor complex. Implications for therapy. Annals of the New York Academy of Sciences. 765: 320-1. PMID 7486630 DOI: 10.1111/j.1749-6632.1995.tb16601.x  1
1995 Fossom LH, Von Lubitz DK, Lin RC, Skolnick P. Neuroprotective actions of 1-aminocyclopropanecarboxylic acid (ACPC): a partial agonist at strychnine-insensitive glycine sites. Neurological Research. 17: 265-9. PMID 7477740  1
1995 Popik P, Layer RT, Fossom LH, Benveniste M, Geter-Douglass B, Witkin JM, Skolnick P. NMDA antagonist properties of the putative antiaddictive drug, ibogaine. The Journal of Pharmacology and Experimental Therapeutics. 275: 753-60. PMID 7473163  1
1995 Zhang W, Liu R, Huang Q, Zhang P, Koehler KF, Harris B, Skolnick P, Cook JM. Syntheses of 5-thienyl and 5-furyl-substituted benzodiazepines: probes of the pharmacophore for benzodiazepine receptor agonists European Journal of Medicinal Chemistry. 30: 483-496. DOI: 10.1016/0223-5234(96)88259-6  1
1994 Adlersberg S, Toren P, Mester R, Rehavi M, Skolnick P, Weizman A. Verapamil is not an antidepressant in patients resistant to tricyclic antidepressants. Clinical Neuropharmacology. 17: 294-7. PMID 9316675  1
1994 Paul IA, Nowak G, Layer RT, Popik P, Skolnick P. Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. The Journal of Pharmacology and Experimental Therapeutics. 269: 95-102. PMID 8169857  1
1994 Zhang W, Koehler KF, Harris B, Skolnick P, Cook JM. Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors. Journal of Medicinal Chemistry. 37: 745-57. PMID 8145224  1
1994 Harris BD, Moody EJ, Basile AS, Skolnick P. Volatile anesthetics bidirectionally and stereospecifically modulate ligand binding to GABA receptors. European Journal of Pharmacology. 267: 269-74. PMID 8088365 DOI: 10.1016/0922-4106(94)90150-3  1
1994 Sei Y, Von Lubitz KJ, Basile AS, Borner MM, Lin RC, Skolnick P, Fossom LH. Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia. Neuroscience Letters. 171: 179-82. PMID 8084486 DOI: 10.1016/0304-3940(94)90634-3  1
1994 Faiman CP, Viu E, Skolnick P, Trullas R. Differential effects of compounds that act at strychnine-insensitive glycine receptors in a punishment procedure. The Journal of Pharmacology and Experimental Therapeutics. 270: 528-33. PMID 8071846  1
1994 Moody EJ, Harris B, Hoehner P, Skolnick P. Inhibition of [3H]isradipine binding to L-type calcium channels by the optical isomers of isoflurane. Lack of stereospecificity. Anesthesiology. 81: 124-8. PMID 8042780  1
1994 Berger P, Farrel K, Sharp F, Skolnick P. Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex. Neuroscience Letters. 168: 147-50. PMID 8028768 DOI: 10.1016/0304-3940(94)90437-5  1
1994 Long JB, Skolnick P. 1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury. European Journal of Pharmacology. 261: 295-301. PMID 7813551 DOI: 10.1016/0014-2999(94)90120-1  1
1994 Moody EJ, Harris BD, Skolnick P. The potential for safer anaesthesia using stereoselective anaesthetics. Trends in Pharmacological Sciences. 15: 387-91. PMID 7809955 DOI: 10.1016/0165-6147(94)90160-0  1
1994 Wong G, Lyon T, Skolnick P. Chronic exposure to benzodiazepine receptor ligands uncouples the gamma-aminobutyric acid type A receptor in WSS-1 cells. Molecular Pharmacology. 46: 1056-62. PMID 7808424  1
1994 Popik P, Layer RT, Skolnick P. The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex. Psychopharmacology. 114: 672-4. PMID 7531855 DOI: 10.1007/BF02245000  1
1994 Lewin AH, Lamb PB, Popik P, Skolnick P. One-step preparation of [2,3-3H]-aminocyclo- propanecarboxylic acid: A useful ligand for strychnine-insensitive glycine receptors Journal of Labelled Compounds and Radiopharmaceuticals. 34: 1063-1068. DOI: 10.1002/jlcr.2580341109  1
1994 He X, Matecka D, Lee KS, Gu ZQ, Rice KC, Wong G, Skolnick P, De Costa BR. Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors Journal of Labelled Compounds and Radiopharmaceuticals. 34: 27-32. DOI: 10.1002/jlcr.2580340105  1
1994 Wong G, Lyon T, Skolnick P. Chronic exposure to benzodiazepine receptor ligands uncouples the γ- aminobutyric acid type A receptor in WSS-1 cells Molecular Pharmacology. 46: 1056-1062.  1
1993 Von Lubitz DK, McKenzie RJ, Lin RC, Devlin TM, Skolnick P. MK-801 is neuroprotective but does not improve survival in severe forebrain ischemia. European Journal of Pharmacology. 233: 95-100. PMID 8472751 DOI: 10.1016/0014-2999(93)90353-J  1
1993 Moody EJ, Harris BD, Skolnick P. Stereospecific actions of the inhalation anesthetic isoflurane at the GABAA receptor complex. Brain Research. 615: 101-6. PMID 8395953 DOI: 10.1016/0006-8993(93)91119-D  1
1993 Wong G, Skolnick P, Katz JL, Witkin JM. Transduction of a discriminative stimulus through a diazepam-insensitive gamma-aminobutyric acidA receptor. The Journal of Pharmacology and Experimental Therapeutics. 266: 570-6. PMID 8394910  1
1993 Wong G, Koehler KF, Skolnick P, Gu ZQ, Ananthan S, Schönholzer P, Hunkeler W, Zhang W, Cook JM. Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors. Journal of Medicinal Chemistry. 36: 1820-30. PMID 8390574  1
1993 Harris B, Wong G, Skolnick P. Neurochemical actions of inhalational anesthetics at the GABAA receptor complex. The Journal of Pharmacology and Experimental Therapeutics. 265: 1392-8. PMID 8389865  1
1993 Fryer RI, Zhang P, Rios R, Gu ZQ, Basile AS, Skolnick P. Structure-activity relationship studies at the benzodiazepine receptor (BZR): a comparison of the substitutent effects of pyrazoloquinolinone analogs. Journal of Medicinal Chemistry. 36: 1669-73. PMID 8388472  1
1993 Gu ZQ, Wong G, Dominguez C, de Costa BR, Rice KC, Skolnick P. Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors. Journal of Medicinal Chemistry. 36: 1001-6. PMID 8386769  1
1993 Ananthan S, Clayton SD, Ealick SE, Wong G, Evoniuk GE, Skolnick P. Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors. Journal of Medicinal Chemistry. 36: 479-90. PMID 8386247  1
1993 Paul IA, Basile AS, Rojas E, Youdim MB, De Costa B, Skolnick P, Pollard HB, Kuijpers GA. Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 7: 1171-8. PMID 8375616  1
1993 Chandler P, Pennington M, Maccecchini ML, Nashed NT, Skolnick P. Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist. The Journal of Biological Chemistry. 268: 17173-8. PMID 8349604  1
1993 Wong G, Gu ZQ, de Costa B, Skolnick P. Labelling of diazepam-sensitive and -insensitive benzodiazepine receptors with [3H]tert-butyl-8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine 3-carboxylate (ZG-63). European Journal of Pharmacology. 247: 57-63. PMID 8258361 DOI: 10.1016/0922-4106(93)90137-X  1
1993 Nowak G, Paul IA, Popik P, Young A, Skolnick P. Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex. European Journal of Pharmacology. 247: 101-2. PMID 8258355 DOI: 10.1016/0922-4106(93)90144-X  1
1993 Lewin AH, Skolnick P, Marvizon JC, Paul IA, Bowen JP. Requirements for high affinity binding of glycine analogs to the glycine site of the NMDA receptor complex. European Journal of Pharmacology. 247: 1-10. PMID 8258354 DOI: 10.1016/0922-4106(93)90131-R  1
1993 Layer RT, Bland LR, Skolnick P. MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity. Brain Research. 625: 38-44. PMID 8242398 DOI: 10.1016/0006-8993(93)90135-A  1
1993 Fride E, McIntyre T, Skolnick P, Arora PK. Immunocompetence in the long sleep and short sleep mouse lines: baseline versus primed responses. Brain, Behavior, and Immunity. 7: 231-42. PMID 8219412 DOI: 10.1006/brbi.1993.1024  1
1993 Nowak G, Trullas R, Layer RT, Skolnick P, Paul IA. Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid. The Journal of Pharmacology and Experimental Therapeutics. 265: 1380-6. PMID 8099620  1
1993 Boje KM, Wong G, Skolnick P. Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures. Brain Research. 603: 207-14. PMID 8096423 DOI: 10.1016/0006-8993(93)91239-O  1
1993 Paul IA, Layer RT, Skolnick P, Nowak G. Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine. European Journal of Pharmacology. 247: 305-11. PMID 7905831 DOI: 10.1016/0922-4106(93)90199-J  1
1993 Trullas R, Skolnick P. Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology. 111: 323-31. PMID 7870970 DOI: 10.1007/BF02244948  1
1993 Gu ZQ, Wong G, Skolnick P, Rice KC. Synthesis and biological evaluation of novel GABA(A)/benzodiazepine receptor ligands selective for the diazepam insensitive (DI) subtype Nida Research Monograph Series. 385.  1
1992 McCabe RT, Skolnick P, Jacobson KA. 2-[2-[4-[2-[2-[ 1,3-Dihydro- 1,1-bis (4-hydroxyphenyl)-3-oxo-5-isobenzofuranthioureidyl]ethylaminocarbonyl]ethyl]phenyl] ethylamino]-5'-N-ethylcarboxamidoadenosine (FITC-APEC): A Fluorescent Ligand For A2a-Adenosine Receptors. Journal of Fluorescence. 2: 217-223. PMID 23772170 DOI: 10.1007/BF00865279  1
1992 Sei Y, Arora PK, Skolnick P, Paul IA. Spatial learning impairment in a murine model of AIDS. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 6: 3008-13. PMID 1644264  1
1992 Skolnick P, Miller R, Young A, Boje K, Trullas R. Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-D-aspartate receptor complex. Psychopharmacology. 107: 489-96. PMID 1534910 DOI: 10.1007/BF02245261  1
1992 Harris B, Moody E, Skolnick P. Isoflurane anesthesia is stereoselective. European Journal of Pharmacology. 217: 215-6. PMID 1425941 DOI: 10.1016/0014-2999(92)90875-5  1
1992 Miller R, La Grone J, Skolnick P, Boje KM. High-performance liquid chromatographic assay for 1-aminocyclopropanecarboxylic acid from plasma and brain. Journal of Chromatography. 578: 103-8. PMID 1400774 DOI: 10.1016/0378-4347(92)80230-N  1
1992 Boje KM, Skolnick P. Ontogeny of glycine-enhanced [3H]MK-801 binding to N-methyl-D-aspartate receptor-coupled ion channels. Brain Research. Developmental Brain Research. 65: 51-6. PMID 1372541 DOI: 10.1016/0165-3806(92)90007-J  1
1992 Sei Y, McIntyre T, Skolnick P, Arora PK. Ethanol inhibits mitogen-induced calcium mobilization in mouse splenocytes. Life Sciences. 50: 419-26. PMID 1346466 DOI: 10.1016/0024-3205(92)90376-Z  1
1992 Sei Y, Skolnick P, Arora PK. Strain variation in immune response and behavior following the death of cage cohorts. The International Journal of Neuroscience. 65: 247-58. PMID 1341687 DOI: 10.3109/00207459209003298  1
1992 Boje KM, Skolnick P, Raber J, Fletcher RT, Chader G. Strychnine-insensitive glycine receptors in embryonic chick retina: characteristics and modulation of NMDA neurotoxicity. Neurochemistry International. 20: 473-86. PMID 1339019 DOI: 10.1016/0197-0186(92)90026-N  1
1992 Wong G, Sei Y, Skolnick P. Stable expression of type I gamma-aminobutyric acidA/benzodiazepine receptors in a transfected cell line. Molecular Pharmacology. 42: 996-1003. PMID 1336119  1
1992 Martin MJ, Trudell ML, Díaz Araúzo H, Allen MS, LaLoggia AJ, Deng L, Schultz CA, Tan YC, Bi Y, Narayanan K. Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site. Journal of Medicinal Chemistry. 35: 4105-17. PMID 1331457 DOI: 10.1021/jm00100a017  1
1992 Allen MS, LaLoggia AJ, Dorn LJ, Martin MJ, Costantino G, Hagen TJ, Koehler KF, Skolnick P, Cook JM. Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. Journal of Medicinal Chemistry. 35: 4001-10. PMID 1331452  1
1992 Skolnick P, Boje K, Miller R, Pennington M, Maccecchini ML. Noncompetitive inhibition of N-methyl-D-aspartate by conantokin-G: evidence for an allosteric interaction at polyamine sites. Journal of Neurochemistry. 59: 1516-21. PMID 1328523  1
1992 Von Lubitz DK, Lin RC, McKenzie RJ, Devlin TM, McCabe RT, Skolnick P. A novel treatment of global cerebral ischaemia with a glycine partial agonist. European Journal of Pharmacology. 219: 153-8. PMID 1327834  0.72
1992 Wong G, Skolnick P. Ro 15-4513 binding to GABAA receptors: subunit composition determines ligand efficacy. Pharmacology, Biochemistry, and Behavior. 42: 107-10. PMID 1326771 DOI: 10.1016/0091-3057(92)90454-N  1
1992 Chang YJ, McCabe RT, Rennert H, Budarf ML, Sayegh R, Emanuel BS, Skolnick P, Strauss JF. The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. Dna and Cell Biology. 11: 471-80. PMID 1326278  1
1992 McCabe RT, Newman AH, Skolnick P. AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors. The Journal of Pharmacology and Experimental Therapeutics. 262: 734-40. PMID 1323661  1
1992 Fride E, Meng R, Skolnick P, Arora PK. Immunoenhancing effects of alprazolam, a benzodiazepine receptor agonist. Annals of the New York Academy of Sciences. 650: 132-9. PMID 1318653  1
1992 Boje KM, Skolnick P. Nitric oxide does not mediate the neurotrophic effects of excitatory amino acids in cultured cerebellar granule neurons. European Journal of Pharmacology. 212: 151-8. PMID 1318207 DOI: 10.1016/0014-2999(92)90323-V  1
1992 Paul IA, Trullas R, Skolnick P, Nowak G. Down-regulation of cortical beta-adrenoceptors by chronic treatment with functional NMDA antagonists. Psychopharmacology. 106: 285-7. PMID 1312732 DOI: 10.1007/BF02801986  1
1992 Wong G, Skolnick P. High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. European Journal of Pharmacology. 225: 63-8. PMID 1311690 DOI: 10.1016/0922-4106(92)90040-3  1
1992 Allen MS, Skolnick P, Cook JM. Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors. Journal of Medicinal Chemistry. 35: 368-74. PMID 1310121  1
1992 Gu ZQ, De Costa BR, Wong G, Rice KC, Skolnick P. Synthesis of [3H]tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4-benzodiazepi ne 3-carboxylate, a selective, high affinity ligand for the diazepam insensitive (DI) subtype of the benzodiazepine receptor Journal of Labelled Compounds and Radiopharmaceuticals. 31: 1049-1055. DOI: 10.1002/jlcr.2580311213  1
1991 de Costa BR, Lewin AH, Rice KC, Skolnick P, Schoenheimer JA. Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes . Journal of Medicinal Chemistry. 34: 1531-8. PMID 2033577  1
1991 Sei Y, McIntyre T, Fride E, Yoshimoto K, Skolnick P, Arora PK. Inhibition of calcium mobilization is an early event in opiate-induced immunosuppression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2194-9. PMID 2022315  1
1991 Sei Y, McIntyre T, Skolnick P, Arora PK. Stress modulates calcium mobilization in immune cells. Life Sciences. 49: 671-6. PMID 1865761 DOI: 10.1016/0024-3205(91)90114-Q  1
1991 McIntyre T, Skolnick P. t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines. Journal of Neurochemistry. 56: 287-93. PMID 1846173  1
1991 Nowak G, Skolnick P, Paul IA. Down-regulation of dopamine1 (D1) receptors by chronic imipramine is species-specific. Pharmacology, Biochemistry, and Behavior. 39: 769-71. PMID 1838413 DOI: 10.1016/0091-3057(91)90162-U  1
1991 Sei Y, Yoshimoto K, McIntyre T, Skolnick P, Arora PK. Morphine-induced thymic hypoplasia is glucocorticoid-dependent. Journal of Immunology (Baltimore, Md. : 1950). 146: 194-8. PMID 1824589  1
1991 Moody EJ, Lewin AH, de Costa BR, Rice KC, Skolnick P. Site-specific acylation of GABA-gated Cl- channels: effects on 36Cl- uptake. European Journal of Pharmacology. 206: 113-8. PMID 1712308  0.6
1991 Trullas R, Folio T, Young A, Miller R, Boje K, Skolnick P. 1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models. European Journal of Pharmacology. 203: 379-85. PMID 1685448 DOI: 10.1016/0014-2999(91)90894-V  1
1991 Basile AS, Jones EA, Skolnick P. The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands. Pharmacological Reviews. 43: 27-71. PMID 1674609  1
1991 Diaz-Arauzo H, Evoniuk GE, Skolnick P, Cook JM. The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic. Journal of Medicinal Chemistry. 34: 1754-6. PMID 1674542  1
1991 Evoniuk GE, Hertzman RP, Skolnick P. A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice. Psychopharmacology. 105: 125-8. PMID 1660607 DOI: 10.1007/BF02316874  1
1991 Arora PK, Hanna EE, Skolnick P. Suppression of cytotoxic T lymphocyte (CTL) activity by FG 7142, a benzodiazepine receptor 'inverse agonist'. Immunopharmacology. 21: 91-7. PMID 1652574  0.84
1991 Basile AS, Hughes RD, Harrison PM, Murata Y, Pannell L, Jones EA, Williams R, Skolnick P. Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure. The New England Journal of Medicine. 325: 473-8. PMID 1649403 DOI: 10.1056/NEJM199108153250705  1
1991 de Costa BR, Lewin A, Schoenheimer JA, Skolnick P, Rice KC. A practical synthesis of isotopically labelled 1-(4-isothiocyanatophenyl)-4-(t-butyl)-2,6,7-trioxabicyclo-[2.2.2]octane, a probe for the benzodiazepine receptor-coupled chloride ionophore Heterocycles. 32: 2343-2355.  1
1990 Petitto JM, McIntyre TD, McRae BL, Skolnick P, Arora PK. Differential immune responsiveness in mouse lines selectively bred for high and low sensitivity to ethanol. Brain, Behavior, and Immunity. 4: 39-49. PMID 2334815 DOI: 10.1016/0889-1591(90)90005-B  1
1990 Havunjian RH, De Costa BR, Rice KC, Skolnick P. Characterization of benzodiazepine receptors with a fluorescence-quenching ligand. The Journal of Biological Chemistry. 265: 22181-6. PMID 2176206  1
1990 Fride E, Skolnick P, Arora PK. Immunoenhancing effects of alprazolam in mice. Life Sciences. 47: 2409-20. PMID 2175825  0.84
1990 Trullas R, Skolnick P. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. European Journal of Pharmacology. 185: 1-10. PMID 2171955 DOI: 10.1016/0014-2999(90)90204-J  1
1990 Gammal SH, Basile AS, Geller D, Skolnick P, Jones EA. Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. Hepatology (Baltimore, Md.). 11: 371-8. PMID 2155865  1
1990 Basile AS, Ostrowski NL, Gammal SH, Jones EA, Skolnick P. The GABAA receptor complex in hepatic encephalopathy. Autoradiographic evidence for the presence of elevated levels of a benzodiazepine receptor ligand. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 3: 61-71. PMID 2154999  1
1990 Fride E, Collins RL, Skolnick P, Arora PK. Strain-dependent association between immune function and paw preference in mice. Brain Research. 522: 246-50. PMID 2146001  0.84
1990 Fride E, Collins RL, Skolnick P, Arora PK. Immune function in lines of mice selected for high or low degrees of behavioral asymmetry. Brain, Behavior, and Immunity. 4: 129-38. PMID 2144194  0.84
1990 Arora PK, Fride E, Petitto J, Waggie K, Skolnick P. Morphine-induced immune alterations in vivo. Cellular Immunology. 126: 343-53. PMID 2107031  0.84
1990 Paul IA, Kuypers G, Youdim M, Skolnick P. Polyamines non-competitively inhibit [3H]3-PPP binding to sigma receptors. European Journal of Pharmacology. 184: 203-4. PMID 1976528 DOI: 10.1016/0014-2999(90)90685-Y  1
1990 Basile AS, Pannell L, Jaouni T, Gammal SH, Fales HM, Jones EA, Skolnick P. Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America. 87: 5263-7. PMID 1973539 DOI: 10.1073/pnas.87.14.5263  1
1990 Jones EA, Basile AS, Skolnick P. Hepatic encephalopathy, GABA-ergic neurotransmission and benzodiazepine receptor ligands. Advances in Experimental Medicine and Biology. 272: 121-34. PMID 1966504 DOI: 10.1016/B978-008045046-9.00585-4  1
1990 Winslow JT, Insel TR, Trullas R, Skolnick P. Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex. European Journal of Pharmacology. 190: 11-21. PMID 1963846 DOI: 10.1016/0014-2999(90)94107-9  1
1990 Basile AS, Ostrowski NL, Gammal SH, Jones EA, Skolnick P. The involvement of the benzodiazepine receptor in hepatic encephalopathy: evidence for the presence of a benzodiazepine receptor ligand. Advances in Biochemical Psychopharmacology. 46: 189-200. PMID 1963266  1
1990 Sei Y, McIntyre TD, Fride E, Yoshimoto K, Skolnick P, Arora PK. Opiate-induced inhibition of calcium flux in immune cells. Nida Research Monograph. 105: 524-9. PMID 1876108  1
1990 Newman AH, McCabe RT, Schoenheimer JA, Skolnick P. [3H]AHN 070: a high affinity irreversible radioligand for characterization of peripheral benzodiazepine receptors. Nida Research Monograph. 105: 435-6. PMID 1652088  0.72
1989 Trullas R, Jackson B, Skolnick P. Anxiolytic properties of 1-aminocyclopropanecarboxylic acid, a ligand at strychnine-insensitive glycine receptors. Pharmacology, Biochemistry, and Behavior. 34: 313-6. PMID 2576136 DOI: 10.1016/0091-3057(89)90317-1  1
1989 Basile AS, Gammal SH, Jones EA, Skolnick P. GABAA receptor complex in an experimental model of hepatic encephalopathy: evidence for elevated levels of an endogenous benzodiazepine receptor ligand. Journal of Neurochemistry. 53: 1057-63. PMID 2549194  1
1989 Jones EA, Skolnick P, Gammal SH, Basile AS, Mullen KD. NIH conference. The gamma-aminobutyric acid A (GABAA) receptor complex and hepatic encephalopathy. Some recent advances. Annals of Internal Medicine. 110: 532-46. PMID 2538099  1
1989 Basile AS, Bolger GT, Lueddens HW, Skolnick P. Electrophysiological actions of Ro5-4864 on cerebellar Purkinje neurons: evidence for "peripheral" benzodiazepine receptor-mediated depression. The Journal of Pharmacology and Experimental Therapeutics. 248: 463-9. PMID 2536432  1
1989 Trullas R, Jackson B, Skolnick P. Genetic differences in a tail suspension test for evaluating antidepressant activity. Psychopharmacology. 99: 287-8. PMID 2508168 DOI: 10.1007/BF00442824  1
1989 Bolger GT, Newman AH, Rice KC, Lueddens HW, Basile AS, Skolnick P. Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle. Canadian Journal of Physiology and Pharmacology. 67: 126-34. PMID 2469529  1
1988 Trullas R, Havoundjian H, Skolnick P. Is the benzodiazepine/GABA receptor chloride ionophore complex involved in physical and emotional stress? Advances in Experimental Medicine and Biology. 245: 183-200. PMID 2906519  1
1988 Basile AS, Gammal SH, Mullen KD, Jones EA, Skolnick P. Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2414-21. PMID 2854841  1
1988 Drugan RC, Basile AS, Crawley JN, Paul SM, Skolnick P. Characterization of stress-induced alterations in [3H] Ro5-4864 binding to peripheral benzodiazepine receptors in rat heart and kidney. Pharmacology, Biochemistry, and Behavior. 30: 1015-20. PMID 2852369 DOI: 10.1016/0091-3057(88)90134-7  1
1988 Trullas R, Ginter H, Jackson B, Skolnick P, Allen MS, Hagen TJ, Cook JM. 3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties. Life Sciences. 43: 1189-97. PMID 2845211 DOI: 10.1016/0024-3205(88)90208-1  1
1988 Bolger GT, Skolnick P, Rice KC, Weissman BA. Differential regulation of mu-opiate receptors in heroin- and morphine-dependent rats. Febs Letters. 234: 22-6. PMID 2839362 DOI: 10.1016/0014-5793(88)81294-8  1
1988 Basile AS, Lueddens HW, Skolnick P. Regulation of renal peripheral benzodiazepine receptors by anion transport inhibitors. Life Sciences. 42: 715-26. PMID 2828800 DOI: 10.1016/0024-3205(88)90464-X  1
1988 Basile AS, Skolnick P. Tissue specific regulation of "peripheral-type" benzodiazepine receptor density after chemical sympathectomy. Life Sciences. 42: 273-83. PMID 2826958 DOI: 10.1016/0024-3205(88)90636-4  1
1988 McIntyre TD, Trullas R, Skolnick P. Asymmetrical activation of GABA-gated chloride channels in cerebral cortex. Pharmacology, Biochemistry, and Behavior. 30: 911-6. PMID 2465553 DOI: 10.1016/0091-3057(88)90119-0  1
1988 McIntyre TD, Trullas R, Skolnick P. Differences in the biophysical properties of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex in the long-sleep and short-sleep mouse lines. Journal of Neurochemistry. 51: 642-7. PMID 2455777  1
1988 Bolger GT, Lesieur P, Basile AS, Skolnick P. Modulation of neurotransmitter metabolism by dihydropyridine calcium channel ligands in mouse brain. Brain Research. 438: 101-7. PMID 2449929 DOI: 10.1016/0006-8993(88)91328-5  1
1987 Trullas R, Ginter H, Skolnick P. A benzodiazepine receptor inverse agonist inhibits stress-induced ulcer formation. Pharmacology, Biochemistry, and Behavior. 27: 35-9. PMID 3039540 DOI: 10.1016/0091-3057(87)90473-4  1
1987 Bolger GT, Basile AS, Janowsky AJ, Paul SM, Skolnick P. Regulation of dihydropyridine calcium antagonist binding sites in the rat hippocampus following neurochemical lesions. Journal of Neuroscience Research. 17: 285-90. PMID 3037095 DOI: 10.1002/jnr.490170313  1
1987 Basile AS, Skolnick P. Preservation of "peripheral" benzodiazepine receptors: differential effects of freezing on [3H]Ro 5-4864 and [3H]PK 11195 binding. Journal of Pharmacological Methods. 17: 149-56. PMID 3035290 DOI: 10.1016/0160-5402(87)90025-8  1
1987 Trullas R, Havoundjian H, Zamir N, Paul S, Skolnick P. Environmentally-induced modification of the benzodiazepine/GABA receptor coupled chloride ionophore. Psychopharmacology. 91: 384-90. PMID 3031719 DOI: 10.1007/BF00518197  1
1987 Bolger GT, Marcus KA, Daly JW, Skolnick P. Local anesthetics differentiate dihydropyridine calcium antagonist binding sites in rat brain and cardiac membranes. The Journal of Pharmacology and Experimental Therapeutics. 240: 922-30. PMID 3031279  1
1987 Basile AS, Ostrowski NL, Skolnick P. Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy. The Journal of Pharmacology and Experimental Therapeutics. 240: 1006-13. PMID 3031271  1
1987 Drugan RC, Basile AS, Crawley JN, Paul SM, Skolnick P. "Peripheral" benzodiazepine binding sites in the Maudsley reactive rat: selective decrease confined to peripheral tissues. Brain Research Bulletin. 18: 143-5. PMID 3030509 DOI: 10.1016/0361-9230(87)90044-X  1
1987 Trudell ML, Basile AS, Shannon HE, Skolnick P, Cook JM. Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands. Journal of Medicinal Chemistry. 30: 456-8. PMID 3029372  1
1987 Bolger GT, Marcus KA, Thibou R, Skolnick P, Weissman BA. Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations. Canadian Journal of Physiology and Pharmacology. 65: 2338-45. PMID 2835135  1
1987 Havoundjian H, Trullas R, Paul S, Skolnick P. A physiological role of the benzodiazepine/GABA receptor-chloride ionophore complex in stress. Advances in Experimental Medicine and Biology. 221: 459-75. PMID 2829587  1
1987 Basile AS, Weissman BA, Skolnick P. Maximal electroshock increases the density of [3H]Ro 5-4864 binding to mouse cerebral cortex. Brain Research Bulletin. 19: 1-7. PMID 2820550 DOI: 10.1016/0361-9230(87)90158-4  1
1987 Trullas R, Havoundjian H, Skolnick P. Stress-induced changes in t-[35S]butylbicyclophosphorothionate binding to gamma-aminobutyric acid-gated chloride channels are mimicked by in vitro occupation of benzodiazepine receptors. Journal of Neurochemistry. 49: 968-74. PMID 2440992  1
1986 Skolnick P, Trullas R, Havoundjian H, Paul S. The benzodiazepine/GABA receptor complex in anxiety. Clinical Neuropharmacology. 9: 43-5. PMID 3032433  1
1986 Basile AS, Klein DC, Skolnick P. Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Brain Research. 387: 127-35. PMID 3024779 DOI: 10.1016/0169-328X(86)90004-5  1
1986 Drugan RC, Basile AS, Crawley JN, Paul SM, Skolnick P. Inescapable shock reduces [3H]Ro 5-4864 binding to "peripheral-type" benzodiazepine receptors in the rat. Pharmacology, Biochemistry, and Behavior. 24: 1673-7. PMID 3016760 DOI: 10.1016/0091-3057(86)90504-6  1
1986 Paul SM, Schwartz RD, Creveling CR, Hollingsworth EB, Daly JW, Skolnick P. GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. Science (New York, N.Y.). 233: 228-9. PMID 3014649  1
1986 Bolger GT, Weissman BA, Lueddens H, Barrett JE, Witkin J, Paul SM, Skolnick P. Dihydropyridine calcium channel antagonists binding in non-mammalian vertebrates: characterization and relationship to 'peripheral-type' binding sites for benzodiazepines. Brain Research. 368: 351-6. PMID 3008928 DOI: 10.1016/0006-8993(86)90580-9  1
1986 Basile AS, Skolnick P. Subcellular localization of "peripheral-type" binding sites for benzodiazepines in rat brain. Journal of Neurochemistry. 46: 305-8. PMID 2999338  1
1986 Bolger GT, Rafferty MF, Weissman BA, Rice KC, Skolnick P. Acylating phencyclidines irreversibly enhance brain calcium antagonist binding. Pharmacology, Biochemistry, and Behavior. 25: 51-7. PMID 2944131 DOI: 10.1016/0091-3057(86)90229-7  1
1986 Barrett JE, Witkin JM, Mansbach RS, Skolnick P, Weissman BA. Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 238: 1009-13. PMID 2875168  1
1985 Weissman BA, Cott J, Weber KH, Skolnick P. Are "peripheral-type" binding sites for benzodiazepines in brain related to the convulsant actions of Ro 5-4864? Progress in Clinical and Biological Research. 192: 197-203. PMID 3001752  1
1985 Mantione CR, Goldman ME, Weissman BA, Paul SM, Skolnick P. Endogenous inhibitors of [3H] Ro 5-4864 binding to "peripheral-type" binding sites for benzodiazepines are present in peripheral tissues and brain. Progress in Clinical and Biological Research. 192: 167-73. PMID 3001748  1
1985 Bolger GT, Weissman BA, Lueddens H, Basile AS, Mantione CR, Barrett JE, Witkin JM, Paul SM, Skolnick P. Late evolutionary appearance of 'peripheral-type' binding sites for benzodiazepines. Brain Research. 338: 366-70. PMID 2992689 DOI: 10.1016/0006-8993(85)90170-2  1
1985 Basile AS, Paul SM, Skolnick P. Adrenalectomy reduces the density of 'peripheral-type' binding sites for benzodiazepines in the rat kidney. European Journal of Pharmacology. 110: 149-50. PMID 2988979 DOI: 10.1016/0014-2999(85)90044-5  1
1985 Mendelson WB, Martin JV, Wagner R, Roseberry C, Skolnick P, Weissman BA, Squires R. Are the toxicities of pentobarbital and ethanol mediated by the GABA-benzodiazepine receptor-chloride ionophore complex? European Journal of Pharmacology. 108: 63-70. PMID 2984019 DOI: 10.1016/0014-2999(85)90283-3  1
1985 Skolnick P, Weissman BA, Youdim MB. Monoaminergic involvement in the pharmacological actions of buspirone. British Journal of Pharmacology. 86: 637-44. PMID 2933109  1
1985 Bolger GT, Weissman BA, Skolnick P. The behavioral effects of the calcium agonist Bay K 8644 in the mouse: antagonism by the calcium antagonist nifedipine. Naunyn-Schmiedeberg's Archives of Pharmacology. 328: 373-7. PMID 2581145 DOI: 10.1007/BF00692903  1
1985 Weissman BA, Cott J, Jackson JA, Bolger GT, Weber KH, Horst WD, Paul SM, Skolnick P. "Peripheral-type" binding sites for benzodiazepines in brain: relationship to the convulsant actions of Ro 5-4864. Journal of Neurochemistry. 44: 1494-9. PMID 2580949 DOI: 10.1111/j.1471-4159.1985.tb08787.x  1
1984 Weissman BA, Burke TR, Rice KC, Skolnick P. Alkyl-substituted gamma-butyrolactones inhibit [35S]TBPS binding to a GABA linked chloride ionophore. European Journal of Pharmacology. 105: 195-6. PMID 6489449 DOI: 10.1016/0014-2999(84)90669-1  1
1984 Weissman BA, Cott J, Hommer D, Paul S, Skolnick P. Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864. European Journal of Pharmacology. 97: 257-63. PMID 6323193 DOI: 10.1016/0014-2999(84)90457-6  1
1984 Weissman BA, Bolger GT, Isaac L, Paul SM, Skolnick P. Characterization of the binding of [3H]Ro 5-4864, a convulsant benzodiazepine, to guinea pig brain. Journal of Neurochemistry. 42: 969-75. PMID 6321666  1
1984 Skolnick P, Paul SM, Weissman BA. Preclinical pharmacology of buspirone hydrochloride. Pharmacotherapy. 4: 308-14. PMID 6151169  1
1984 Weissman BA, Skolnick P, Klein DC. Regulation of "peripheral-type" binding sites for benzodiazepines in the pineal gland. Pharmacology, Biochemistry, and Behavior. 21: 821-4. PMID 6097917  1
1984 Mantione CR, Weissman BA, Goldman ME, Paul SM, Skolnick P. Endogenous inhibitors of 4'-[3H]chlorodiazepam (Ro 5-4864) binding to 'peripheral' sites for benzodiazepines. Febs Letters. 176: 69-74. PMID 6092140 DOI: 10.1016/0014-5793(84)80913-8  1
1984 Bolger GT, Mezey E, Cott J, Weissman BA, Paul SM, Skolnick P. Differential regulation of 'central' and 'peripheral' benzodiazepine binding sites in the rat olfactory bulb. European Journal of Pharmacology. 105: 143-8. PMID 6092112 DOI: 10.1016/0014-2999(84)90658-7  1
1983 Weissman BA, Cott J, Paul SM, Skolnick P. Ro 5-4864: a potent benzodiazepine convulsant. European Journal of Pharmacology. 90: 149-50. PMID 6873175 DOI: 10.1016/0014-2999(83)90229-7  1
1983 Weissman BA, Cott J, Hommer D, Quirion R, Paul S, Skolnick P. Pharmacological, electrophysiological, and neurochemical actions of the convulsant benzodiazepine Ro 5-4864 (4'-chlordiazepam). Advances in Biochemical Psychopharmacology. 38: 139-51. PMID 6670623  1
1981 Nimit Y, Skolnick P, Daly JW. Adenosine and cyclic AMP in rat cerebral cortical slices: effects of adenosine uptake inhibitors and adenosine deaminase inhibitors. Journal of Neurochemistry. 36: 908-12. PMID 6259294  1
1978 Skolnick P, Nimitkitpaisan Y, Stalvey L, Daly JW. Inhibition of brain adenosine deaminase by 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nonyl) adenine. Journal of Neurochemistry. 30: 1479-82. PMID 670988  1
1978 Skolnick P, Daly JW, Segal DS. Neurochemical and behavioral effects of clonidine and related imidazolines: interaction with alpha-adrenoceptors. European Journal of Pharmacology. 47: 451-5. PMID 204500 DOI: 10.1016/0014-2999(78)90126-7  1
1978 Davis JN, Arnett CD, Hoyler E, Stalvey LP, Daly JW, Skolnick P. Brain alpha-adrenergic receptors: comparison of [3H]WB 4101 binding with norepinephrine-stimulated cyclic AMP accumulation in rat cerebral cortex. Brain Research. 159: 125-35. PMID 31963  1
1978 Skolnick P, Stalvey LP, Daly JW, Hoyler E, Davis JN. Binding of alpha-and beta-adrenergic ligands to cerebral cortical membranes: effect of 6-hydroxydopamine treatment and relationship to the responsiveness of cyclic amp-generating systems in two rat strains. European Journal of Pharmacology. 47: 201-10. PMID 23299 DOI: 10.1016/0014-2999(78)90391-6  1
1977 Skolnick P, Daly JW. Strain differences in responsiveness of norepinephrine-sensitive adenosine 3',5'-monophosphate-generating systems in rat brain slices after intraventricular administration of 6-hydroxydopamine. European Journal of Pharmacology. 41: 145-52. PMID 188662  1
1977 Skolnick P, Stalvey LP, Daly JW. Blockade of central beta-adrenergic receptors by tazolol (1-isopropylamino-3-(2-thiazoloxy)-2-propanol). Life Sciences. 21: 1655-63. PMID 23478  1
1976 Skolnick P, Daly JW. Interaction of clonidine with pre- and post-synaptic adrenergic receptors of rat brain: effects on cyclic AMP-generating systems. European Journal of Pharmacology. 39: 11-21. PMID 183964  1
1976 Skolnick P, Daly JW. Antagonism of alpha- and beta-adrenergic-mediated accumulations of cyclic AMP in rat cerebral cortical slices by the beta-antagonist (-)alprenolol. Life Sciences. 19: 497-503. PMID 8683  1
1976 Skolnick P, Daly JW, Freedman R, Hoffer BJ. Interrelationship between catecholamine-stimulated formation of adenosine 3',5'-monophosphate in cerebellar slices and inhibitory effects on cerebellar Purkinje cells: antagonism by neuroleptic compounds. The Journal of Pharmacology and Experimental Therapeutics. 197: 280-92. PMID 5595  1
1975 Skolnick P, Daly JW. Stimulation of adenosine 3',5'-monophosphate formation by alpha and beta adrenergic agonists in rat cerebral cortical slices: effects of clonidine. Molecular Pharmacology. 11: 545-51. PMID 241008  1
1975 Skolnick P, Daly JW. Stimulation of adenosine 3',5'-monophosphate formation in rat cerebral cortical slices by methoxamine: interaction with an alpha adrenergic receptor. The Journal of Pharmacology and Experimental Therapeutics. 193: 549-58. PMID 238025  1
1975 Weissman BA, Skolnick P. Stimulation of Adenosine 3',5'-monophosphate formation in incubated rat hypothalamus by estrogenic compounds: relationship to biologic potency and blockade by anti-estrogens. Neuroendocrinology. 18: 27-34. PMID 233937  1
1975 Weissman BA, Daly JW, Skolnick P. Diethylstilbestrol-elicited accumulation of cyclic AMP in incubated rat hypothalamus. Endocrinology. 97: 1559-66. PMID 173528 DOI: 10.1210/endo-97-6-1559  1
1975 Skolnick P, Schultz J, Daly JW. Repetitive stimulation of cyclic adenosine 3',5'-monophosphate formation by adrenergic agonists in incubated slices from rat cerebral cortex. Journal of Neurochemistry. 24: 1263-5. PMID 165265  1
1975 Skolnick P, Daly JW. Functional compartments of adenine nucleotides serving as precursors of adenosine 3',5'-monophosphate in mouse cerebral cortex. Journal of Neurochemistry. 24: 451-6. PMID 163293  1
1974 Skolnick P, Daly JW. The accumulation of adenosine 3',5'-monophosphate in cerebral cortical slices of the quaking mouse, a neurologic mutant. Brain Research. 73: 513-25. PMID 4366158  1
1974 Skolnick P, Daly JW. Norepinephrine-sensitive adenylate cyclases in rat brain: relation to behavior and tyrosine hydroxylase. Science (New York, N.Y.). 184: 175-7. PMID 4150105  1
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