Michael G. Kaplitt, MD/PhD - Publications

Affiliations: 
Neurological Surgery New York Presbyterian/Weill Cornell 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rezai AR, Ranjan M, D'Haese PF, Haut MW, Carpenter J, Najib U, Mehta RI, Chazen JL, Zibly Z, Yates JR, Hodder SL, Kaplitt M. Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound. Proceedings of the National Academy of Sciences of the United States of America. PMID 32284421 DOI: 10.1073/Pnas.2002571117  0.309
2019 Carrillo-Reid L, Day M, Xie Z, Melendez AE, Kondapalli J, Plotkin JL, Wokosin DL, Chen Y, Kress GJ, Kaplitt M, Ilijic E, Guzman JN, Chan SS, Surmeier DJ. Mutant huntingtin enhances activation of dendritic Kv4 K channels in striatal spiny projection neurons. Elife. 8. PMID 31017573 DOI: 10.7554/Elife.40818  0.344
2018 Niethammer M, Tang CC, Vo A, Nguyen N, Spetsieris P, Dhawan V, Ma Y, Small M, Feigin A, During MJ, Kaplitt MG, Eidelberg D. Gene therapy reduces Parkinson's disease symptoms by reorganizing functional brain connectivity. Science Translational Medicine. 10. PMID 30487248 DOI: 10.1126/Scitranslmed.Aau0713  0.354
2018 Stavarache MA, Petersen N, Jurgens EM, Milstein ER, Rosenfeld ZB, Ballon DJ, Kaplitt MG. Safe and stable noninvasive focal gene delivery to the mammalian brain following focused ultrasound. Journal of Neurosurgery. 1-10. PMID 29701544 DOI: 10.3171/2017.8.Jns17790  0.764
2017 Kelm-Nelson CA, Brauer AFL, Barth KJ, Lake JM, Sinnen MLK, Stehula FJ, Muslu C, Marongiu R, Kaplitt MG, Ciucci MR. Characterization of early-onset motor deficits in the Pink1 -/- mouse model of Parkinson disease. Brain Research. PMID 29229503 DOI: 10.1016/J.Brainres.2017.12.002  0.749
2017 Niethammer M, Tang CC, LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, ... ... Kaplitt MG, et al. Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease. Jci Insight. 2: e90133. PMID 28405611 DOI: 10.1172/Jci.Insight.90133  0.331
2017 Schweitzer M, Stavarache M, Petersen N, Bakas S, Tsiouris AJ, Davatzikos C, Kaplitt MG, Souweidane MM. SCDT-37. MODULATION OF CONVECTION ENHANCED DELIVERY (CED) DISTRIBUTION USING FOCUSED ULTRASOUND (FUS) Neuro-Oncology. 19: vi272-vi272. DOI: 10.1093/Neuonc/Nox168.1118  0.724
2016 Marongiu R, Arango-Lievano M, Francardo V, Morgenstern P, Zhang X, Cenci MA, Svenningsson P, Greengard P, Kaplitt MG. Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787858 DOI: 10.1073/Pnas.1524387113  0.764
2016 Schintu N, Zhang X, Alvarsson A, Marongiu R, Kaplitt MG, Greengard P, Svenningsson P. p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787846 DOI: 10.1073/Pnas.1524303113  0.755
2016 Virk MS, Sagi Y, Medrihan L, Leung J, Kaplitt MG, Greengard P. Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proceedings of the National Academy of Sciences of the United States of America. PMID 26733685 DOI: 10.1073/Pnas.1524183113  0.474
2015 Stavarache MA, Musatov S, McGill M, Vernov M, Kaplitt MG. The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals. Neurobiology of Disease. 82: 487-494. PMID 26232589 DOI: 10.1016/J.Nbd.2015.07.013  0.367
2015 Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P. Erratum: Nitric oxide regulates synaptic transmission between spiny projection neurons (Proc Natl Acad Sci USA (2014) 111 49 (17636-17641) DOI: 10.1073/pnas.1420162111) Proceedings of the National Academy of Sciences of the United States of America. 112. PMID 25787251 DOI: 10.1073/Pnas.1504794112  0.412
2015 Gürsel DB, Banu MA, Berry N, Marongiu R, Burkhardt JK, Kobylarz K, Kaplitt MG, Rafii S, Boockvar JA. Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling. Journal of Neuro-Oncology. 121: 19-29. PMID 25344882 DOI: 10.1007/S11060-014-1602-3  0.73
2014 Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P. Nitric oxide regulates synaptic transmission between spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 111: 17636-41. PMID 25413364 DOI: 10.1073/Pnas.1420162111  0.441
2014 Plotkin JL, Day M, Peterson JD, Xie Z, Kress GJ, Rafalovich I, Kondapalli J, Gertler TS, Flajolet M, Greengard P, Stavarache M, Kaplitt MG, Rosinski J, Chan CS, Surmeier DJ. Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease. Neuron. 83: 178-88. PMID 24991961 DOI: 10.1016/J.Neuron.2014.05.032  0.482
2014 Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG. Cell-type specific expression of p11 controls cocaine reward. Biological Psychiatry. 76: 794-801. PMID 24725970 DOI: 10.1016/J.Biopsych.2014.02.012  0.724
2013 Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, Kehr J, Gerhardt GA, Warner-Schmidt J, Arango-Lievano M, Kaplitt MG, Ogren SO, Greengard P, Svenningsson P. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Molecular Psychiatry. 18: 1096-105. PMID 23032875 DOI: 10.1038/Mp.2012.130  0.747
2012 Sondhi D, Johnson L, Purpura K, Monette S, Souweidane MM, Kaplitt MG, Kosofsky B, Yohay K, Ballon D, Dyke J, Kaminksy SM, Hackett NR, Crystal RG. Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Human Gene Therapy Methods. 23: 324-35. PMID 23131032 DOI: 10.1089/Hgtb.2012.120  0.32
2012 Warner-Schmidt JL, Schmidt EF, Marshall JJ, Rubin AJ, Arango-Lievano M, Kaplitt MG, Ibañez-Tallon I, Heintz N, Greengard P. Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. 109: 11360-5. PMID 22733786 DOI: 10.1073/Pnas.1209293109  0.75
2011 Morgenstern PF, Marongiu R, Musatov SA, Kaplitt MG. Adeno-associated viral gene delivery in neurodegenerative disease. Methods in Molecular Biology (Clifton, N.J.). 793: 443-55. PMID 21913118 DOI: 10.1007/978-1-61779-328-8_29  0.755
2011 LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, ... ... Kaplitt MG, et al. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. The Lancet. Neurology. 10: 309-19. PMID 21419704 DOI: 10.1016/S1474-4422(11)70039-4  0.337
2010 Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Lievano M, Arango-Llievano M, Ghose S, Vernov M, Stavarache M, Stavarche M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Science Translational Medicine. 2: 54ra76. PMID 20962330 DOI: 10.1126/Scitranslmed.3001079  0.785
2010 Souweidane MM, Fraser JF, Arkin LM, Sondhi D, Hackett NR, Kaminsky SM, Heier L, Kosofsky BE, Worgall S, Crystal RG, Kaplitt MG. Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. Journal of Neurosurgery. Pediatrics. 6: 115-22. PMID 20672930 DOI: 10.3171/2010.4.Peds09507  0.317
2010 Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Lievano M, Ghose S, Vernov M, Stavarache M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens (Science Translational Medicine (2010) 2, (62er4)) Science Translational Medicine. 2. DOI: 10.1126/Scitranslmed.3001996  0.776
2010 Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Llievano M, Ghose S, Vernov M, Stavarche M, Musatov S, Flajolet M, Svenningsson P, Greengard P, Kaplitt MG. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens (Science Translational Medicine (2010) 2, (55er3)) Science Translational Medicine. 2. DOI: 10.1126/scitranslmed.3001841  0.768
2009 Schultz KN, von Esenwein SA, Hu M, Bennett AL, Kennedy RT, Musatov S, Toran-Allerand CD, Kaplitt MG, Young LJ, Becker JB. Viral vector-mediated overexpression of estrogen receptor-alpha in striatum enhances the estradiol-induced motor activity in female rats and estradiol-modulated GABA release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1897-903. PMID 19211896 DOI: 10.1523/Jneurosci.4647-08.2009  0.328
2007 Feigin A, Kaplitt MG, Tang C, Lin T, Mattis P, Dhawan V, During MJ, Eidelberg D. Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 19559-64. PMID 18042721 DOI: 10.1073/Pnas.0706006104  0.328
2007 Kaplitt MG, Feigin A, Tang C, Fitzsimons HL, Mattis P, Lawlor PA, Bland RJ, Young D, Strybing K, Eidelberg D, During MJ. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial. Lancet. 369: 2097-105. PMID 17586305 DOI: 10.1016/S0140-6736(07)60982-9  0.369
2007 Emborg ME, Carbon M, Holden JE, During MJ, Ma Y, Tang C, Moirano J, Fitzsimons H, Roitberg BZ, Tuccar E, Roberts A, Kaplitt MG, Eidelberg D. Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 501-9. PMID 16835631 DOI: 10.1038/Sj.Jcbfm.9600364  0.36
2006 Asanuma K, Tang C, Ma Y, Dhawan V, Mattis P, Edwards C, Kaplitt MG, Feigin A, Eidelberg D. Network modulation in the treatment of Parkinson's disease. Brain : a Journal of Neurology. 129: 2667-78. PMID 16844713 DOI: 10.1093/Brain/Awl162  0.34
2006 Musatov S, Chen W, Pfaff DW, Kaplitt MG, Ogawa S. RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors. Proceedings of the National Academy of Sciences of the United States of America. 103: 10456-60. PMID 16803960 DOI: 10.1073/Pnas.0603045103  0.341
2006 Cooper LB, Chan DK, Roediger FC, Shaffer BR, Fraser JF, Musatov S, Selesnick SH, Kaplitt MG. AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 27: 484-90. PMID 16791039 DOI: 10.1097/01.Mao.0000202647.19355.6A  0.312
2006 Kaplitt MG, Eidelberg D, Feigin A, Fitzimmons H, Lawlor P, Strybing K, Cox M, Tang C, Bland R, During MJ. 727. Improvements in Clinical and Radiographic Outcomes in a Phase I Study of AAV-GAD Gene Therapy for Parkinson's Disease Molecular Therapy. 13: S280-S281. DOI: 10.1016/J.Ymthe.2006.08.807  0.303
2005 Kaplitt MG, Browne S, Stavarache M, Goldfein J, Musatov S. 884 Antiapoptotic Gene Therapy Improves Animal Models of Parkinson's and Huntington's Diseases. Neurosurgery. 57: 424-425. PMID 28184808 DOI: 10.1093/Neurosurgery/57.2.424B  0.323
2005 Hackett NR, Sondhi D, Kaminsky SM, Worgall S, Arkin LA, Hollmann CA, Shungu DC, Mao X, Dyke JP, Heier L, Souweidane M, Kaplitt M, Crystal RG. 969. Development of Non-Invasive Imaging Strategies to Assess the Impact of Gene Therapy: Phenotypic Assessment of the Neurodegenerative CNS Disorder Late Infantile Neuronal Ceroid Lipofuscinosis Using Magnetic Resonance Spectroscopy Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.512  0.334
2004 Crystal RG, Sondhi D, Hackett NR, Kaminsky SM, Worgall S, Stieg P, Souweidane M, Hosain S, Heier L, Ballon D, Dinner M, Wisniewski K, Kaplitt M, Greenwald BM, Howell JD, et al. Clinical protocol. Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis. Human Gene Therapy. 15: 1131-54. PMID 15610613 DOI: 10.1089/Hum.2004.15.1131  0.356
2004 Musatov S, Roberts J, Brooks AI, Pena J, Betchen S, Pfaff DW, Kaplitt MG. Inhibition of neuronal phenotype by PTEN in PC12 cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 3627-31. PMID 14990793 DOI: 10.1073/Pnas.0308289101  0.323
2004 Hamani C, Saint-Cyr JA, Fraser J, Kaplitt M, Lozano AM. The subthalamic nucleus in the context of movement disorders Brain. 127: 4-20. PMID 14607789 DOI: 10.1093/Brain/Awh029  0.353
2003 Scott RE, Wu-Peng XS, Kaplitt MG, Pfaff DW. Gene transfer and in vivo promoter analysis of the rat progesterone receptor using a herpes simplex virus viral vector. Brain Research. Molecular Brain Research. 114: 91-100. PMID 12829318 DOI: 10.1016/S0169-328X(03)00084-6  0.325
2002 Luo J, Kaplitt MG, Fitzsimons HL, Zuzga DS, Liu Y, Oshinsky ML, During MJ. Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science (New York, N.Y.). 298: 425-9. PMID 12376704 DOI: 10.1126/Science.1074549  0.382
1998 During MJ, Xu R, Young D, Kaplitt MG, Sherwin RS, Leone P. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nature Medicine. 4: 1131-5. PMID 9771745 DOI: 10.1038/2625  0.328
1998 During MJ, Samulski RJ, Elsworth JD, Kaplitt MG, Leone P, Xiao X, Li J, Freese A, Taylor JR, Roth RH, Sladek JR, O'Malley KL, Redmond DE. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Therapy. 5: 820-7. PMID 9747462 DOI: 10.1038/Sj.Gt.3300650  0.371
1998 Kaplitt MG, Darakchiev B, During MJ. Prospects for gene therapy in pediatric neurosurgery. Pediatric Neurosurgery. 28: 3-14. PMID 9693323 DOI: 10.1159/000028611  0.348
1997 Freese A, Kaplitt MG, O'Connor WM, Abbey M, Langer D, Leone P, O'Connor MJ, During MJ. Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: implications for a gene therapy approach to epilepsy. Epilepsia. 38: 759-66. PMID 9579902 DOI: 10.1111/J.1528-1157.1997.Tb01462.X  0.346
1997 O'Connor WM, Davidson BL, Kaplitt MG, Abbey MV, During MJ, Leone P, Langer D, O'Connor MJ, Freese A. Adenovirus vector-mediated gene transfer into human epileptogenic brain slices: prospects for gene therapy in epilepsy. Experimental Neurology. 148: 167-78. PMID 9398459 DOI: 10.1006/Exnr.1997.6658  0.347
1997 Rosenfeld MR, Bergman I, Schramm L, Griffin JA, Kaplitt MG, Meneses PI. Adeno-associated viral vector gene transfer into leptomeningeal xenografts. Journal of Neuro-Oncology. 34: 139-44. PMID 9210060 DOI: 10.1023/A:1005702228721  0.331
1996 Kaplitt M, Gouras GK, Makimura H, Jovanovic J, Sweeney D, Greengard P, Relkin NR, Gandy S. Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications. Annals of the New York Academy of Sciences. 802: 42-9. PMID 8993483 DOI: 10.1111/J.1749-6632.1996.Tb32597.X  0.698
1996 Freese A, During MJ, Davidson BL, Gennarelli TA, Kaplitt MG, Flamm ES, Snyder PJ. Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release. The Journal of Clinical Endocrinology and Metabolism. 81: 2401-4. PMID 8964885 DOI: 10.1210/Jcem.81.6.8964885  0.335
1996 Kaplitt MG, Pfaff DW. Viral Vectors for Gene Delivery and Expression in the CNS Methods (San Diego, Calif.). 10: 343-50. PMID 8954846 DOI: 10.1006/Meth.1996.0112  0.323
1996 Holtmaat AJ, Hermens WT, Oestreicher AB, Gispen WH, Kaplitt MG, Verhaagen J. Efficient adenoviral vector-directed expression of a foreign gene to neurons and sustentacular cells in the mouse olfactory neuroepithelium. Brain Research. Molecular Brain Research. 41: 148-56. PMID 8883946 DOI: 10.1016/0169-328X(96)00085-X  0.34
1996 Freese A, Stern M, Kaplitt MG, O'Connor WM, Abbey MV, O'Connor MJ, During MJ. Prospects for gene therapy in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 11: 469-88. PMID 8866488 DOI: 10.1002/Mds.870110502  0.361
1995 Rosenfeld MR, Meneses P, Dalmau J, Drobnjak M, Cordon-Cardo C, Kaplitt MG. Gene transfer of wild-type p53 results in restoration of tumor-suppressor function in a medulloblastoma cell line. Neurology. 45: 1533-9. PMID 7644054 DOI: 10.1212/Wnl.45.8.1533  0.356
1994 Kaplitt MG, Kwong AD, Kleopoulos SP, Mobbs CV, Rabkin SD, Pfaff DW. Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector. Proceedings of the National Academy of Sciences of the United States of America. 91: 8979-83. PMID 8090756 DOI: 10.1073/Pnas.91.19.8979  0.312
1994 Kaplitt MG, Leone P, Samulski RJ, Xiao X, Pfaff DW, O'Malley KL, During MJ. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature Genetics. 8: 148-54. PMID 7842013 DOI: 10.1038/Ng1094-148  0.361
1994 Wood MJ, Byrnes AP, Kaplitt MG, Pfaff DW, Rabkin SD, Charlton HM. Specific patterns of defective HSV-1 gene transfer in the adult central nervous system: implications for gene targeting. Experimental Neurology. 130: 127-40. PMID 7821388 DOI: 10.1006/Exnr.1994.1192  0.342
1991 Kaplitt MG, Pfaus JG, Kleopoulos SP, Hanlon BA, Rabkin SD, Pfaff DW. Expression of a functional foreign gene in adult mammalian brain following in Vivo transfer via a herpes simplex virus type 1 defective viral vector. Molecular and Cellular Neurosciences. 2: 320-30. PMID 19912815 DOI: 10.1016/1044-7431(91)90062-S  0.316
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