Maria Kristiina Lehtinen - Publications

Affiliations: 
2006 Harvard University, Cambridge, MA, United States 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Xu H, Lotfy P, Gelb S, Pragana A, Hehnly C, Byer LIJ, Shipley FB, Zawadzki ME, Cui J, Deng L, Taylor M, Webb M, Lidov HGW, Andermann ML, Chiu IM, ... ... Lehtinen MK, et al. The choroid plexus synergizes with immune cells during neuroinflammation. Cell. PMID 39089253 DOI: 10.1016/j.cell.2024.07.002  0.721
2024 Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, et al. Antibodies expand the scope of angiotensin receptor pharmacology. Nature Chemical Biology. PMID 38744986 DOI: 10.1038/s41589-024-01620-6  0.607
2024 Fame RM, Ali I, Lehtinen MK, Kanarek N, Petrova B. Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid. Metabolites. 14. PMID 38392972 DOI: 10.3390/metabo14020079  0.711
2024 Courtney Y, Head JP, Yimer ED, Dani N, Shipley FB, Libermann TA, Lehtinen MK. A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development. Biorxiv : the Preprint Server For Biology. PMID 38260341 DOI: 10.1101/2024.01.08.574486  0.815
2023 Fame RM, Ali I, Lehtinen MK, Kanarek N, Petrova B. Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid. Biorxiv : the Preprint Server For Biology. PMID 38116027 DOI: 10.1101/2023.12.07.570731  0.713
2023 Petrova B, Lacey TE, Culhane AJ, Cui J, Raskin A, Misra A, Lehtinen MK, Kanarek N. Metabolomics of Mouse Embryonic CSF Following Maternal Immune Activation. Biorxiv : the Preprint Server For Biology. PMID 38105934 DOI: 10.1101/2023.12.06.570507  0.307
2023 Xu H, Dugué GP, Cantaut-Belarif Y, Lejeune FX, Gupta S, Wyart C, Lehtinen MK. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Fluids and Barriers of the Cns. 20: 89. PMID 38049798 DOI: 10.1186/s12987-023-00491-8  0.695
2023 Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC. Antibodies Expand the Scope of Angiotensin Receptor Pharmacology. Biorxiv : the Preprint Server For Biology. PMID 37662341 DOI: 10.1101/2023.08.23.554128  0.608
2023 Xu H, Lotfy P, Gelb S, Pragana A, Hehnly C, Shipley FB, Zawadzki ME, Cui J, Deng L, Taylor M, Webb M, Lidov HGW, Andermann ML, Chiu IM, Ordovas-Montanes J, ... Lehtinen MK, et al. A collaboration between immune cells and the choroid plexus epithelium in brain inflammation. Biorxiv : the Preprint Server For Biology. PMID 37609192 DOI: 10.1101/2023.08.07.552298  0.719
2023 Xu H, Dugué GP, Cantaut-Belarif Y, Lejeune FX, Gupta S, Wyart C, Lehtinen MK. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Biorxiv : the Preprint Server For Biology. PMID 37577601 DOI: 10.1101/2023.08.01.551512  0.695
2023 Gelb S, Lehtinen MK. Snapshot: Choroid plexus brain barrier. Cell. 186: 3522-3522.e1. PMID 37541203 DOI: 10.1016/j.cell.2023.07.015  0.347
2023 Fame RM, Kalugin PN, Petrova B, Xu H, Soden PA, Shipley FB, Dani N, Grant B, Pragana A, Head JP, Gupta S, Shannon ML, Chifamba FF, Hawks-Mayer H, Vernon A, ... ... Lehtinen MK, et al. Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution. Nature Communications. 14: 3720. PMID 37349305 DOI: 10.1038/s41467-023-39326-3  0.784
2023 Fame RM, Xu H, Pragana A, Lehtinen M. Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1. Fluids and Barriers of the Cns. 20: 45. PMID 37328833 DOI: 10.1186/s12987-023-00438-z  0.798
2023 Sadegh C, Xu H, Sutin J, Fatou B, Gupta S, Pragana A, Taylor M, Kalugin PN, Zawadzki ME, Alturkistani O, Shipley FB, Dani N, Fame RM, Wurie Z, Talati P, ... ... Lehtinen MK, et al. Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus. Neuron. PMID 36893755 DOI: 10.1016/j.neuron.2023.02.020  0.776
2023 Karimy JK, Newville JC, Sadegh C, Morris JA, Monuki ES, Limbrick DD, McAllister Ii JP, Koschnitzky JE, Lehtinen MK, Jantzie LL. Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus". Fluids and Barriers of the Cns. 20: 4. PMID 36639792 DOI: 10.1186/s12987-023-00406-7  0.769
2022 Saunders NR, Dziegielewska KM, Fame RM, Lehtinen MK, Liddelow SA. The choroid plexus: a missing link in our understanding of brain development and function. Physiological Reviews. PMID 36173801 DOI: 10.1152/physrev.00060.2021  0.729
2022 Li Q, Han Z, Singh N, Terré B, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K, ... ... Lehtinen MK, et al. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death and Differentiation. PMID 35322202 DOI: 10.1038/s41418-022-00950-z  0.694
2022 Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, ... ... Lehtinen MK, et al. Correction: MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development (Cambridge, England). 149. PMID 35119069 DOI: 10.1242/dev.200517  0.692
2021 Fame RM, Lehtinen MK. Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis. Frontiers in Cell and Developmental Biology. 9: 780207. PMID 34888312 DOI: 10.3389/fcell.2021.780207  0.695
2021 Cui J, Xu H, Lehtinen MK. Macrophages on the margin: choroid plexus immune responses. Trends in Neurosciences. PMID 34312005 DOI: 10.1016/j.tins.2021.07.002  0.675
2021 Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, ... ... Lehtinen MK, et al. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development (Cambridge, England). 148. PMID 34032267 DOI: 10.1242/dev.192054  0.729
2021 Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, ... ... Lehtinen MK, et al. A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. PMID 33932339 DOI: 10.1016/j.cell.2021.04.003  0.8
2021 Xu H, Fame RM, Sadegh C, Sutin J, Naranjo C, Della Syau, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin PY, ... Lehtinen MK, et al. Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development. Nature Communications. 12: 447. PMID 33469018 DOI: 10.1038/s41467-020-20666-3  0.785
2020 Cui J, Shipley FB, Shannon ML, Alturkistani O, Dani N, Webb MD, Sugden AU, Andermann ML, Lehtinen MK. Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation. Developmental Cell. PMID 33038331 DOI: 10.1016/j.devcel.2020.09.020  0.316
2020 Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, ... ... Lehtinen MK, et al. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron. PMID 32961128 DOI: 10.1016/J.Neuron.2020.08.024  0.752
2020 Xu H, Lehtinen MK. Choroid Plexus Organoids: Harnessing CSF Gatekeepers for Brain Therapeutics. Cell Stem Cell. 27: 191-192. PMID 32763178 DOI: 10.1016/J.Stem.2020.07.009  0.712
2020 Xu H, Lehtinen MK. Cerebrospinal Fluid Magnetic Resonance Imaging: Improving Early Diagnosis of Autism and Other Neurodevelopmental Conditions. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 5: 635-637. PMID 32646616 DOI: 10.1016/J.Bpsc.2020.05.007  0.651
2020 Fame RM, Lehtinen MK. Emergence and Developmental Roles of the Cerebrospinal Fluid System. Developmental Cell. 52: 261-275. PMID 32049038 DOI: 10.1016/J.Devcel.2020.01.027  0.75
2019 Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK. Concerted metabolic shift in early forebrain alters the CSF proteome and depends on cMYC downregulation for mitochondrial maturation. Development (Cambridge, England). PMID 31575649 DOI: 10.1242/Dev.182857  0.766
2019 Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK. Spatio-temporal gradient of cortical neuron death contributes to microcephaly in knock-in mouse model of ligase 4 syndrome. The American Journal of Pathology. PMID 31541646 DOI: 10.1016/J.Ajpath.2019.08.010  0.377
2019 Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 178: 867-886.e24. PMID 31398341 DOI: 10.1016/J.Cell.2019.07.024  0.707
2019 Fame RM, Lehtinen MK. Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members. Neuron. 102: 278-279. PMID 30998898 DOI: 10.1016/J.Neuron.2019.02.040  0.703
2019 Sadegh C, Xu H, Shipley F, Dani N, Lehtinen MK. Intraventricular Hemorrhage Induces Rapid Calcium Signaling and Transcriptional Changes in the Developing Choroid Plexus Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_134  0.777
2018 Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, ... ... Lehtinen MK, et al. Sodium Channel SCN3A (Na1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development. Neuron. PMID 30146301 DOI: 10.1016/J.Neuron.2018.07.052  0.741
2018 Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, ... ... Lehtinen MK, et al. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Reports. 24: 973-986.e8. PMID 30044992 DOI: 10.1016/J.Celrep.2018.06.100  0.785
2018 Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK. Downregulation of ribosome biogenesis during early forebrain development. Elife. 7. PMID 29745900 DOI: 10.7554/Elife.36998  0.764
2018 Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK. Mice Expressing c-MYC in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. The American Journal of Pathology. PMID 29545198 DOI: 10.1016/J.Ajpath.2018.02.009  0.701
2018 Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK. Author response: Downregulation of ribosome biogenesis during early forebrain development Elife. DOI: 10.7554/Elife.36998.018  0.437
2017 Anttonen AK, Laari A, Kousi M, Yang YJ, Jääskeläinen T, Somer M, Siintola E, Jakkula E, Muona M, Tegelberg S, Lönnqvist T, Pihko H, Valanne L, Paetau A, Lun MP, ... ... Lehtinen MK, et al. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. Brain : a Journal of Neurology. PMID 28335020 DOI: 10.1093/Brain/Awx040  0.341
2017 Lehtinen MK. The brain's matchmakers. Science Translational Medicine. 9. PMID 28275158 DOI: 10.1126/Scitranslmed.Aam9863  0.335
2017 Lehtinen MK. Epilepsy clocks in Science Translational Medicine. 9: eaaq1237. DOI: 10.1126/Scitranslmed.Aaq1237  0.309
2016 Dani N, Lehtinen MK. CSF Makes Waves in the Neural Stem Cell Niche. Cell Stem Cell. 19: 565-566. PMID 27814476 DOI: 10.1016/J.Stem.2016.10.008  0.356
2016 Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nature Cell Biology. PMID 26999738 DOI: 10.1038/Ncb3327  0.341
2015 Chau KF, Springel MW, Broadbelt KG, Park HY, Topal S, Lun MP, Mullan H, Maynard T, Steen H, LaMantia AS, Lehtinen MK. Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure. Developmental Cell. 35: 789-802. PMID 26702835 DOI: 10.1016/J.Devcel.2015.11.015  0.433
2015 Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nature Reviews. Neuroscience. 16: 445-57. PMID 26174708 DOI: 10.1038/Nrn3921  0.682
2015 Chang JT, Lehtinen MK, Sive H. Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Developmental Neurobiology. PMID 25980532 DOI: 10.1002/Dneu.22300  0.644
2015 Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, ... ... Lehtinen MK, et al. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4903-16. PMID 25810521 DOI: 10.1523/Jneurosci.3081-14.2015  0.702
2013 Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17553-9. PMID 24198345 DOI: 10.1523/Jneurosci.3258-13.2013  0.657
2013 Zappaterra MW, LaMantia AS, Walsh CA, Lehtinen MK. Isolation of cerebrospinal fluid from rodent embryos for use with dissected cerebral cortical explants. Journal of Visualized Experiments : Jove. e50333. PMID 23524481 DOI: 10.3791/50333  0.595
2012 Lehtinen MK. Adult neurogenesis: VCAM stems the tide. Cell Stem Cell. 11: 137-8. PMID 22862936 DOI: 10.1016/J.Stem.2012.07.012  0.328
2012 Poduri A, Evrony GD, Cai X, Elhosary PC, Beroukhim R, Lehtinen MK, Hills LB, Heinzen EL, Hill A, Hill RS, Barry BJ, Bourgeois BF, Riviello JJ, Barkovich AJ, Black PM, et al. Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron. 74: 41-8. PMID 22500628 DOI: 10.1016/J.Neuron.2012.03.010  0.781
2012 Zappaterra MW, Lehtinen MK. The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond. Cellular and Molecular Life Sciences : Cmls. 69: 2863-78. PMID 22415326 DOI: 10.1007/S00018-012-0957-X  0.47
2011 Lehtinen MK, Walsh CA. Neurogenesis at the brain-cerebrospinal fluid interface. Annual Review of Cell and Developmental Biology. 27: 653-79. PMID 21801012 DOI: 10.1146/Annurev-Cellbio-092910-154026  0.583
2011 Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 69: 893-905. PMID 21382550 DOI: 10.1016/J.Neuron.2011.01.023  0.682
2010 Tucker ES, Lehtinen MK, Maynard T, Zirlinger M, Dulac C, Rawson N, Pevny L, Lamantia AS. Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development (Cambridge, England). 137: 2471-81. PMID 20573694 DOI: 10.1242/Dev.049718  0.324
2010 Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 66: 69-84. PMID 20399730 DOI: 10.1016/J.Neuron.2010.03.019  0.533
2009 Lehtinen MK, Tegelberg S, Schipper H, Su H, Zukor H, Manninen O, Kopra O, Joensuu T, Hakala P, Bonni A, Lehesjoki AE. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5910-5. PMID 19420257 DOI: 10.1523/Jneurosci.0682-09.2009  0.561
2009 Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A. Regulation of neuronal cell death by MST1-FOXO1 signaling. The Journal of Biological Chemistry. 284: 11285-92. PMID 19221179 DOI: 10.1074/Jbc.M900461200  0.609
2008 Lehtinen MK, Bonni A. Demystifying MST family kinases in cell death. Current Molecular Medicine. 8: 313-8. PMID 18537638 DOI: 10.2174/156652408784533805  0.599
2006 Lehtinen MK, Bonni A. Modeling oxidative stress in the central nervous system. Current Molecular Medicine. 6: 871-81. PMID 17168738 DOI: 10.2174/156652406779010786  0.575
2006 Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 125: 987-1001. PMID 16751106 DOI: 10.1016/J.Cell.2006.03.046  0.742
2005 Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. The Journal of Biological Chemistry. 280: 2818-25. PMID 15537643 DOI: 10.1074/Jbc.M408741200  0.596
2003 Shalizi A, Lehtinen M, Gaudilliere B, Donovan N, Han J, Konishi Y, Bonni A. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7326-36. PMID 12917366 DOI: 10.1523/Jneurosci.23-19-07326.2003  0.775
2002 Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Molecular Cell. 9: 1005-16. PMID 12049737 DOI: 10.1016/S1097-2765(02)00524-5  0.594
2001 Wiemelt AP, Lehtinen M, McMorris FA. Agonists calcitonin, corticotropin-releasing hormone, and vasoactive intestinal peptide, but not prostaglandins or beta-adrenergic agonists, elevate cyclic adenosine monophosphate levels in oligodendroglial cells. Journal of Neuroscience Research. 65: 165-72. PMID 11438985 DOI: 10.1002/Jnr.1139  0.315
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