cached image

David M. Holtzman - Publications

Affiliations: 
Neurology Washington University, Saint Louis, St. Louis, MO 
Area:
Alzheimer's, amyloid
Website:
http://neuro.wustl.edu/aboutus/facultybiographies/holtzman.htm

432 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Seo DO, Holtzman DM. Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 31738402 DOI: 10.1093/gerona/glz262  0.52
2019 Gallardo G, Wong CH, Ricardez SM, Mann CN, Lin KH, Leyns CEG, Jiang H, Holtzman DM. Targeting tauopathy with engineered tau-degrading intrabodies. Molecular Neurodegeneration. 14: 38. PMID 31640765 DOI: 10.1186/s13024-019-0340-6  0.64
2019 Huynh TV, Wang C, Tran AC, Tabor GT, Mahan TE, Francis CM, Finn MB, Spellman R, Manis M, Tanzi RE, Ulrich JD, Holtzman DM. Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular Neurodegeneration. 14: 37. PMID 31623648 DOI: 10.1186/s13024-019-0337-1  0.6
2019 Shi Y, Manis M, Long J, Wang K, Sullivan PM, Remolina Serrano J, Hoyle R, Holtzman DM. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. The Journal of Experimental Medicine. PMID 31601677 DOI: 10.1084/jem.20190980  0.32
2019 Seo DO, Boros BD, Holtzman DM. The microbiome: A target for Alzheimer disease? Cell Research. PMID 31488883 DOI: 10.1038/s41422-019-0227-7  0.52
2019 Xu J, Sun J, Perrin RJ, Mach RH, Bales KR, Morris JC, Benzinger TLS, Holtzman DM. Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains. Annals of Clinical and Translational Neurology. 6: 1423-1434. PMID 31402620 DOI: 10.1002/acn3.50837  0.6
2019 Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, et al. A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain. Alzheimer's Research & Therapy. 11: 71. PMID 31399126 DOI: 10.1186/s13195-019-0524-x  0.6
2019 Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Li Y, Gordon BA, Holtzman DM, Morris JC, Benzinger TLS, Xiong C, Fagan AM, Bateman RJ. High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis. Neurology. PMID 31371569 DOI: 10.1212/WNL.0000000000008081  0.68
2019 Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM. TREM2 function impedes tau seeding in neuritic plaques. Nature Neuroscience. PMID 31235932 DOI: 10.1038/s41593-019-0433-0  0.64
2019 Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, ... ... Holtzman DM, et al. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30846386 DOI: 10.1016/j.jalz.2018.12.019  0.68
2019 Patel TK, Habimana-Griffin L, Gao X, Xu B, Achilefu S, Alitalo K, McKee CA, Sheehan PW, Musiek ES, Xiong C, Coble D, Holtzman DM. Dural lymphatics regulate clearance of extracellular tau from the CNS. Molecular Neurodegeneration. 14: 11. PMID 30813965 DOI: 10.1186/s13024-019-0312-x  0.6
2019 Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR, ... ... Holtzman DM, et al. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a Journal of Neurology. PMID 30753379 DOI: 10.1093/brain/awz019  0.68
2019 Toedebusch CD, McLeland JS, Schaibley CM, Banks IR, Boyd J, Morris JC, Holtzman DM, Lucey BP. Multi-Modal Home Sleep Monitoring in Older Adults. Journal of Visualized Experiments : Jove. PMID 30741255 DOI: 10.3791/58823  0.6
2019 Ju YS, Holtzman DM. Reply to "Obstructive sleep apnea treatment and amyloid-β in cerebrospinal fluid". Annals of Neurology. PMID 30706528 DOI: 10.1002/ana.25424  0.88
2019 Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, Finn MB, Manis M, Geerling JC, Fuller PM, Lucey BP, Holtzman DM. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science (New York, N.Y.). PMID 30679382 DOI: 10.1126/science.aav2546  0.8
2019 Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease. Science Translational Medicine. 11. PMID 30626715 DOI: 10.1126/scitranslmed.aau6550  0.6
2019 Morris JC, Schindler SE, McCue LM, Moulder KL, Benzinger TLS, Cruchaga C, Fagan AM, Grant E, Gordon BA, Holtzman DM, Xiong C. Assessment of Racial Disparities in Biomarkers for Alzheimer Disease. Jama Neurology. PMID 30615028 DOI: 10.1001/jamaneurol.2018.4249  0.6
2018 Ju YS, Zangrilli MA, Finn MB, Fagan AM, Holtzman DM. Obstructive sleep apnea treatment, slow wave activity, and amyloid-β. Annals of Neurology. PMID 30597615 DOI: 10.1002/ana.25408  0.88
2018 Babulal GM, Chen S, Williams MM, Trani JF, Bakhshi P, Chao GL, Stout SH, Fagan AM, Benzinger TLS, Holtzman DM, Morris JC, Roe CM. Depression and Alzheimer's Disease Biomarkers Predict Driving Decline. Journal of Alzheimer's Disease : Jad. PMID 30400098 DOI: 10.3233/JAD-180564  0.6
2018 Lessard CB, Malnik SL, Zhou Y, Ladd TB, Cruz PE, Ran Y, Mahan TE, Chakrabaty P, Holtzman DM, Ulrich JD, Colonna M, Golde TE. High-affinity interactions and signal transduction between Aβ oligomers and TREM2. Embo Molecular Medicine. PMID 30341064 DOI: 10.15252/emmm.201809027  0.6
2018 Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Molecular Neurodegeneration. 13: 57. PMID 30340601 DOI: 10.1186/s13024-018-0286-0  0.96
2018 Roe CM, Ances BM, Head D, Babulal GM, Stout SH, Grant EA, Hassenstab J, Xiong C, Holtzman DM, Benzinger TLS, Schindler SE, Fagan AM, Morris JC. Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain : a Journal of Neurology. PMID 30304397 DOI: 10.1093/brain/awy244  0.6
2018 McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. PMID 30217935 DOI: 10.1212/WNL.0000000000006277  0.6
2018 Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, ... ... Holtzman DM, et al. Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP. Brain : a Journal of Neurology. PMID 29945247 DOI: 10.1093/brain/awy159  0.64
2018 Roe CM, Babulal GM, Stout SH, Ott BR, Carr DB, Williams MM, Benzinger TLS, Fagan AM, Holtzman DM, Ances BM, Morris JC. Using the A/T/N Framework to Examine Driving in Preclinical AD. Geriatrics (Basel, Switzerland). 3. PMID 29805967 DOI: 10.3390/geriatrics3020023  0.6
2018 Hettinger JC, Lee H, Bu G, Holtzman DM, Cirrito JR. AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model. Molecular Neurodegeneration. 13: 22. PMID 29764453 DOI: 10.1186/s13024-018-0256-6  0.8
2018 Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, et al. White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. Plos One. 13: e0195838. PMID 29742105 DOI: 10.1371/journal.pone.0195838  0.6
2018 Mishra S, Blazey TM, Holtzman DM, Cruchaga C, Su Y, Morris JC, Benzinger TLS, Gordon BA. Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ɛ4 genotype. Brain : a Journal of Neurology. PMID 29672664 DOI: 10.1093/brain/awy103  0.6
2018 Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, ... ... Holtzman DM, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation. PMID 29600961 DOI: 10.1172/JCI96429  0.64
2018 Sutphen CL, McCue L, Herries EM, Xiong C, Ladenson JH, Holtzman DM, Fagan AM. Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29580670 DOI: 10.1016/j.jalz.2018.01.012  0.6
2018 Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29501462 DOI: 10.1016/j.jalz.2018.01.013  0.6
2018 Ulrich JD, Ulland TK, Mahan TE, Nyström S, Nilsson KP, Song WM, Zhou Y, Reinartz M, Choi S, Jiang H, Stewart FR, Anderson E, Wang Y, Colonna M, Holtzman DM. ApoE facilitates the microglial response to amyloid plaque pathology. The Journal of Experimental Medicine. PMID 29483128 DOI: 10.1084/jem.20171265  0.64
2018 Gordon BA, Blazey TM, Su Y, Hari-Raj A, Dincer A, Flores S, Christensen J, McDade E, Wang G, Xiong C, Cairns NJ, Hassenstab J, Marcus DS, Fagan AM, Jack CR, ... ... Holtzman DM, et al. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study. The Lancet. Neurology. PMID 29397305 DOI: 10.1016/S1474-4422(18)30028-0  0.64
2018 Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES. Regulation of amyloid-β dynamics and pathology by the circadian clock. The Journal of Experimental Medicine. PMID 29382695 DOI: 10.1084/jem.20172347  0.64
2018 Musiek ES, Bhimasani M, Zangrilli MA, Morris JC, Holtzman DM, Ju YS. Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. Jama Neurology. PMID 29379963 DOI: 10.1001/jamaneurol.2017.4719  0.88
2018 Stout SH, Babulal GM, Ma C, Carr DB, Head DM, Grant EA, Williams MM, Holtzman DM, Fagan AM, Morris JC, Roe CM. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29328928 DOI: 10.1016/j.jalz.2017.11.011  0.6
2017 Huynh TV, Liao F, Francis CM, Robinson GO, Serrano JR, Jiang H, Roh J, Finn MB, Sullivan PM, Esparza TJ, Stewart FR, Mahan TE, Ulrich JD, Cole T, Holtzman DM. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron. 96: 1013-1023.e4. PMID 29216448 DOI: 10.1016/j.neuron.2017.11.014  0.64
2017 West T, Hu Y, Verghese PB, Bateman RJ, Braunstein JB, Fogelman I, Budur K, Florian H, Mendonca N, Holtzman DM. Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies. The Journal of Prevention of Alzheimer's Disease. 4: 236-241. PMID 29181488 DOI: 10.14283/jpad.2017.36  0.96
2017 Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, ... ... Holtzman DM, et al. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078331 DOI: 10.1073/pnas.1708568114  0.64
2017 Leyns CEG, Ulrich JD, Finn MB, Stewart FR, Koscal LJ, Remolina Serrano J, Robinson GO, Anderson E, Colonna M, Holtzman DM. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. 114: 11524-11529. PMID 29073081 DOI: 10.1073/pnas.1710311114  0.64
2017 Kang SS, Kurti A, Baker KE, Liu CC, Colonna M, Ulrich JD, Holtzman DM, Bu G, Fryer JD. Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal. Human Molecular Genetics. PMID 29040522 DOI: 10.1093/hmg/ddx366  0.68
2017 Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, ... ... Holtzman DM, et al. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 549: 523-527. PMID 28959956 DOI: 10.1038/nature24016  0.64
2017 Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, et al. Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28943286 DOI: 10.1016/j.jalz.2017.08.013  0.6
2017 Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, ... ... Holtzman DM, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 47: 566-581.e9. PMID 28930663 DOI: 10.1016/j.immuni.2017.08.008  0.44
2017 Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM. Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels. Brain : a Journal of Neurology. 140: 2104-2111. PMID 28899014 DOI: 10.1093/brain/awx148  0.88
2017 Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, ... ... Holtzman DM, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 170: 649-663.e13. PMID 28802038 DOI: 10.1016/j.cell.2017.07.023  0.44
2017 Ovod V, Ramsey KN, Mawuenyega KG, Bollinger JG, Hicks T, Schneider T, Sullivan M, Paumier K, Holtzman DM, Morris JC, Benzinger T, Fagan AM, Patterson BW, Bateman RJ. Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28734653 DOI: 10.1016/j.jalz.2017.06.2266  0.6
2017 Schindler SE, Sutphen CL, Teunissen C, McCue LM, Morris JC, Holtzman DM, Mulder SD, Scheltens P, Xiong C, Fagan AM. Upward drift in cerebrospinal fluid amyloid-β 42 assay values for more than 10 years. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28710906 DOI: 10.1016/j.jalz.2017.06.2264  0.6
2017 Ising C, Gallardo G, Leyns CEG, Wong CH, Jiang H, Stewart F, Koscal LJ, Roh J, Robinson GO, Serrano JR, Holtzman DM. Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy. The Journal of Experimental Medicine. PMID 28536241 DOI: 10.1084/jem.2016212505192017c  0.64
2017 Schindler SE, Jasielec MS, Weng H, Hassenstab JJ, Grober E, McCue LM, Morris JC, Holtzman DM, Xiong C, Fagan AM. Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease. Neurobiology of Aging. 56: 25-32. PMID 28482211 DOI: 10.1016/j.neurobiolaging.2017.04.004  0.6
2017 Lucey BP, Fagan AM, Holtzman DM, Morris JC, Bateman RJ. Diurnal oscillation of CSF Aβ and other AD biomarkers. Molecular Neurodegeneration. 12: 36. PMID 28478762 DOI: 10.1186/s13024-017-0161-4  0.6
2017 Babulal GM, Stout SH, Head D, Holtzman DM, Fagan AM, Morris JC, Roe CM. Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report. Journal of Alzheimer's Disease : Jad. PMID 28453487 DOI: 10.3233/JAD-170067  0.6
2017 Roe CM, Babulal GM, Head DM, Stout SH, Vernon EK, Ghoshal N, Garland B, Barco PP, Williams MM, Johnson A, Fierberg R, Fague MS, Xiong C, Mormino E, Grant EA, ... Holtzman DM, et al. Preclinical Alzheimer's disease and longitudinal driving decline. Alzheimer's & Dementia (New York, N. Y.). 3: 74-82. PMID 28435853 DOI: 10.1016/j.trci.2016.11.006  0.6
2017 Ulrich JD, Ulland TK, Colonna M, Holtzman DM. Elucidating the Role of TREM2 in Alzheimer's Disease. Neuron. 94: 237-248. PMID 28426958 DOI: 10.1016/j.neuron.2017.02.042  0.44
2017 Yanamandra K, Patel TK, Jiang H, Schindler S, Ulrich JD, Boxer AL, Miller BL, Kerwin DR, Gallardo G, Stewart F, Finn MB, Cairns NJ, Verghese PB, Fogelman I, West T, ... ... Holtzman DM, et al. Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy. Science Translational Medicine. 9. PMID 28424326 DOI: 10.1126/scitranslmed.aal2029  0.96
2017 Holth JK, Mahan TE, Robinson GO, Rocha A, Holtzman DM. Altered sleep and EEG power in the P301S Tau transgenic mouse model. Annals of Clinical and Translational Neurology. 4: 180-190. PMID 28275652 DOI: 10.1002/acn3.390  0.4
2017 Liu CC, Hu J, Zhao N, Wang J, Na W, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275161 DOI: 10.1523/JNEUROSCI.3442-16.2017  0.8
2017 Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Holtzman DM, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y  0.6
2017 Huynh TV, Davis AA, Ulrich JD, Holtzman DM. Apolipoprotein E and Alzheimer Disease: The influence of apoE on amyloid-β and other amyloidogenic proteins. Journal of Lipid Research. PMID 28246336 DOI: 10.1194/jlr.R075481  0.44
2017 Ooms SJ, Zempel JM, Holtzman DM, Ju YS. Automated selective disruption of slow wave sleep. Journal of Neuroscience Methods. PMID 28238859 DOI: 10.1016/j.jneumeth.2017.02.008  0.88
2017 Pankiewicz JE, Baquero-Buitrago J, Sanchez S, Lopez-Contreras J, Kim J, Sullivan PM, Holtzman DM, Sadowski MJ. APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice. Molecular Neurodegeneration. 12: 12. PMID 28143566 DOI: 10.1186/s13024-017-0156-1  1
2017 Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R. Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular Neurodegeneration. 12: 3. PMID 28081701 DOI: 10.1186/s13024-016-0147-7  0.96
2016 Ghosal K, Haag M, Verghese PB, West T, Veenstra T, Braunstein JB, Bateman RJ, Holtzman DM, Landreth GE. A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects. Alzheimer's & Dementia (New York, N. Y.). 2: 110-120. PMID 29067298 DOI: 10.1016/j.trci.2016.06.001  0.96
2016 Ju YS, Holtzman DM. Reply to "Do repetitive Valsalva maneuvers reduce glymphatic clearance?" Annals of Neurology. PMID 28019658 DOI: 10.1002/ana.24849  0.88
2016 Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takana T, Holtzman DM, Nedergaard M, Deane R. Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Molecular Neurodegeneration. 11: 74. PMID 27931262 DOI: 10.1186/s13024-016-0138-8  0.96
2016 Musiek ES, Holtzman DM. Mechanisms linking circadian clocks, sleep, and neurodegeneration. Science (New York, N.Y.). 354: 1004-1008. PMID 27885006 DOI: 10.1126/science.aah4968  0.6
2016 Stanley M, Macauley SL, Caesar EE, Koscal LJ, Moritz W, Robinson GO, Roh J, Keyser J, Jiang H, Holtzman DM. The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 11704-11715. PMID 27852778 DOI: 10.1523/JNEUROSCI.2119-16.2016  0.64
2016 Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, ... Holtzman DM, et al. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. Bmc Neurology. 16: 217. PMID 27832767 DOI: 10.1186/s12883-016-0742-9  0.6
2016 Chung WS, Verghese PB, Chakraborty C, Joung J, Hyman BT, Ulrich JD, Holtzman DM, Barres BA. Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559087 DOI: 10.1073/pnas.1609896113  0.44
2016 Gordon BA, Blazey T, Su Y, Fagan AM, Holtzman DM, Morris JC, Benzinger TL. Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology. Jama Neurology. PMID 27548756 DOI: 10.1001/jamaneurol.2016.2642  0.6
2016 Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM. Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Annals of Clinical and Translational Neurology. 3: 434-42. PMID 27547771 DOI: 10.1002/acn3.308  0.6
2016 Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, ... ... Holtzman DM, et al. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 27521573 DOI: 10.1093/brain/aww200  0.44
2016 Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Scientific Reports. 6: 30028. PMID 27443609 DOI: 10.1038/srep30028  0.44
2016 Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TL, Fagan AM, Morris JC, Roe CM. Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. PMID 27426238 DOI: 10.1016/j.jagp.2016.04.004  0.6
2016 Vlassenko AG, McCue L, Jasielec MS, Su Y, Gordon BA, Xiong C, Holtzman DM, Benzinger TL, Morris JC, Fagan AM. Imaging and cerebrospinal fluid biomarkers in early preclinical Alzheimer disease. Annals of Neurology. PMID 27398953 DOI: 10.1002/ana.24719  0.44
2016 Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG, Paul SM. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. Neurobiology of Aging. 44: 159-172. PMID 27318144 DOI: 10.1016/j.neurobiolaging.2016.04.020  0.32
2016 Vos SJ, Gordon BA, Su Y, Visser PJ, Holtzman DM, Morris JC, Fagan AM, Benzinger TL. NIA-AA staging of preclinical Alzheimer disease: discordance and concordance of CSF and imaging biomarkers. Neurobiology of Aging. 44: 1-8. PMID 27318129 DOI: 10.1016/j.neurobiolaging.2016.03.025  0.6
2016 Gordon BA, Friedrichsen K, Brier M, Blazey T, Su Y, Christensen J, Aldea P, McConathy J, Holtzman DM, Cairns NJ, Morris JC, Fagan AM, Ances BM, Benzinger TL. The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging. Brain : a Journal of Neurology. PMID 27286736 DOI: 10.1093/brain/aww139  0.44
2016 Lucey BP, Mcleland JS, Toedebusch CD, Boyd J, Morris JC, Landsness EC, Yamada K, Holtzman DM. Comparison of a single-channel EEG sleep study to polysomnography. Journal of Sleep Research. PMID 27252090 DOI: 10.1111/jsr.12417  0.6
2016 Brier MR, Gordon B, Friedrichsen K, McCarthy J, Stern A, Christensen J, Owen C, Aldea P, Su Y, Hassenstab J, Cairns NJ, Holtzman DM, Fagan AM, Morris JC, Benzinger TL, et al. Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease. Science Translational Medicine. 8: 338ra66. PMID 27169802 DOI: 10.1126/scitranslmed.aaf2362  0.44
2016 Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M. Tau: From research to clinical development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27154059 DOI: 10.1016/j.jalz.2016.03.018  1
2016 Ju YS, Finn MB, Sutphen CL, Herries EM, Jerome GM, Ladenson JH, Crimmins DL, Fagan AM, Holtzman DM. Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid. Annals of Neurology. PMID 27129429 DOI: 10.1002/ana.24672  0.88
2016 Roe CM, Barco PP, Head DM, Ghoshal N, Selsor N, Babulal GM, Fierberg R, Vernon EK, Shulman N, Johnson A, Fague S, Xiong C, Grant EA, Campbell A, Ott BR, ... Holtzman DM, et al. Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals. Alzheimer Disease and Associated Disorders. PMID 27128959 DOI: 10.1097/WAD.0000000000000154  0.6
2016 Ingber AP, Hassenstab J, Fagan AM, Benzinger TL, Grant EA, Holtzman DM, Morris JC, Roe CM. Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future "Non-Cognitive" Outcomes of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27104893 DOI: 10.3233/JAD-150478  0.44
2016 Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, et al. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of Experimental Medicine. PMID 27091843 DOI: 10.1084/jem.20151948  1
2016 Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Science Translational Medicine. 8: 332ra44. PMID 27030596 DOI: 10.1126/scitranslmed.aad3650  0.8
2016 Tarawneh R, D'Angelo G, Crimmins D, Herries E, Griest T, Fagan AM, Zipfel GJ, Ladenson JH, Morris JC, Holtzman DM. Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease. Jama Neurology. PMID 27018940 DOI: 10.1001/jamaneurol.2016.0086  1
2016 Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, et al. White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the Dominantly Inherited Alzheimer Network. Annals of Neurology. PMID 27016429 DOI: 10.1002/ana.24647  0.44
2016 Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, ... ... Holtzman DM, et al. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 292-323. PMID 27012484 DOI: 10.1016/j.jalz.2016.02.002  0.44
2016 Hölttä M, Dean RA, Siemers E, Mawuenyega KG, Sigurdson W, May PC, Holtzman DM, Portelius E, Zetterberg H, Bateman RJ, Blennow K, Gobom J. A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans. Alzheimer's Research & Therapy. 8: 11. PMID 26948580 DOI: 10.1186/s13195-016-0178-x  0.44
2016 Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, Cumming RC. Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1871-8. PMID 26865611 DOI: 10.1523/JNEUROSCI.3131-15.2016  0.44
2016 Ulrich JD, Holtzman DM. TREM2 Function in Alzheimer's disease and neurodegeneration. Acs Chemical Neuroscience. PMID 26854967 DOI: 10.1021/acschemneuro.5b00313  0.44
2016 Piccio L, Deming Y, Del-Águila JL, Ghezzi L, Holtzman DM, Fagan AM, Fenoglio C, Galimberti D, Borroni B, Cruchaga C. Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status. Acta Neuropathologica. PMID 26754641 DOI: 10.1007/s00401-016-1533-5  0.6
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 339-348. PMID 26693175 DOI: 10.1016/j.dadm.2015.06.008  0.6
2015 Moore KM, Girens RE, Larson SK, Jones MR, Restivo JL, Holtzman DM, Cirrito JR, Yuede CM, Zimmerman SD, Timson BF. A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease. Neurobiology of Disease. PMID 26563933 DOI: 10.1016/j.nbd.2015.11.004  0.44
2015 Liao F, Zhang TJ, Jiang H, Lefton KB, Robinson GO, Vassar R, Sullivan PM, Holtzman DM. Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models. Acta Neuropathologica Communications. 3: 70. PMID 26556230 DOI: 10.1186/s40478-015-0250-y  0.64
2015 Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, et al. microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14717-26. PMID 26538644 DOI: 10.1523/JNEUROSCI.2053-15.2015  0.44
2015 Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM. Analysis of in vivo turnover of tau in a mouse model of tauopathy. Molecular Neurodegeneration. 10: 55. PMID 26502977 DOI: 10.1186/s13024-015-0052-5  1
2015 Ulrich JD, Huynh TP, Holtzman DM. Re-evaluation of the Blood-Brain Barrier in the Presence of Alzheimer's Disease Pathology. Neuron. 88: 237-9. PMID 26494271 DOI: 10.1016/j.neuron.2015.10.008  1
2015 Kester MI, Teunissen CE, Sutphen C, Herries EM, Ladenson JH, Xiong C, Scheltens P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM. Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort. Alzheimer's Research & Therapy. 7: 59. PMID 26383836 DOI: 10.1186/s13195-015-0142-1  1
2015 Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/pnas.1510011112  0.44
2015 Kester MI, Teunissen CE, Crimmins DL, Herries EM, Ladenson JH, Scheltens P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM. Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease. Jama Neurology. 1-7. PMID 26366630 DOI: 10.1001/jamaneurol.2015.1867  0.6
2015 Ising C, Stanley M, Holtzman DM. Current thinking on the mechanistic basis of Alzheimer's and implications for drug development. Clinical Pharmacology and Therapeutics. 98: 469-71. PMID 26250900 DOI: 10.1002/cpt.200  0.44
2015 Sutphen CL, Jasielec MS, Shah AR, Macy EM, Xiong C, Vlassenko AG, Benzinger TL, Stoops EE, Vanderstichele HM, Brix B, Darby HD, Vandijck ML, Ladenson JH, Morris JC, Holtzman DM, et al. Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age. Jama Neurology. 72: 1029-1042. PMID 26147946 DOI: 10.1001/jamaneurol.2015.1285  0.44
2015 Macauley SL, Holtzman DM. Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease. Ebiomedicine. 2: 94-5. PMID 26137544 DOI: 10.1016/j.ebiom.2015.01.002  1
2015 Funk KE, Mirbaha H, Jiang H, Holtzman DM, Diamond MI. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of Biological Chemistry. 290: 21652-62. PMID 26126828 DOI: 10.1074/jbc.M115.657924  0.64
2015 Lucey BP, Holtzman DM. How amyloid, sleep and memory connect. Nature Neuroscience. 18: 933-4. PMID 26108720 DOI: 10.1038/nn.4048  1
2015 Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, et al. Age and amyloid effects on human CNS amyloid-beta kinetics. Annals of Neurology. PMID 26040676 DOI: 10.1002/ana.24454  1
2015 Musiek ES, Holtzman DM. Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nature Neuroscience. 18: 800-6. PMID 26007213 DOI: 10.1038/nn.4018  1
2015 Yan P, Zhu A, Liao F, Xiao Q, Kraft AW, Gonzales E, Perez R, Greenberg SM, Holtzman DM, Lee JM. Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy. Stroke; a Journal of Cerebral Circulation. 46: 1633-40. PMID 25944329 DOI: 10.1161/STROKEAHA.115.008582  0.44
2015 Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, Mahan TE, Sutphen CL, Holtzman DM. Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo. The Journal of Clinical Investigation. 125: 2463-7. PMID 25938784 DOI: 10.1172/JCI79742  1
2015 Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T. Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease. Cell Reports. 11: 859-65. PMID 25937280 DOI: 10.1016/j.celrep.2015.04.017  0.8
2015 Liao F, Jiang H, Srivatsan S, Xiao Q, Lefton KB, Yamada K, Mahan TE, Lee JM, Shaw AS, Holtzman DM. Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model. Molecular Neurodegeneration. 10: 12. PMID 25887956 DOI: 10.1186/s13024-015-0006-y  1
2015 Soldan A, Pettigrew C, Lu Y, Wang MC, Selnes O, Albert M, Brown T, Ratnanather JT, Younes L, Miller MI. Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease. Human Brain Mapping. 36: 2826-41. PMID 25879865 DOI: 10.1002/hbm.22810  1
2015 Tarawneh R, Head D, Allison S, Buckles V, Fagan AM, Ladenson JH, Morris JC, Holtzman DM. Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease. Jama Neurology. 72: 656-65. PMID 25867677 DOI: 10.1001/jamaneurol.2015.0202  1
2015 Yanamandra K, Jiang H, Mahan TE, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM. Anti-tau antibody reduces insoluble tau and decreases brain atrophy. Annals of Clinical and Translational Neurology. 2: 278-88. PMID 25815354 DOI: 10.1002/acn3.176  0.64
2015 Sahlholm K, Liao F, Holtzman DM, Xu J, Mach RH. Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice. Biochemical and Biophysical Research Communications. 460: 439-45. PMID 25796326 DOI: 10.1016/j.bbrc.2015.03.052  1
2015 Musiek ES, Xiong DD, Holtzman DM. Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Experimental & Molecular Medicine. 47: e148. PMID 25766617 DOI: 10.1038/emm.2014.121  0.6
2015 Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. 160: 1061-71. PMID 25728668 DOI: 10.1016/j.cell.2015.01.049  0.4
2015 Gordon BA, Zacks JM, Blazey T, Benzinger TL, Morris JC, Fagan AM, Holtzman DM, Balota DA. Task-evoked fMRI changes in attention networks are associated with preclinical Alzheimer's disease biomarkers. Neurobiology of Aging. 36: 1771-9. PMID 25708908 DOI: 10.1016/j.neurobiolaging.2015.01.019  1
2015 Han BH, Zhou ML, Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proceedings of the National Academy of Sciences of the United States of America. 112: E881-90. PMID 25675483 DOI: 10.1073/pnas.1414930112  0.44
2015 Hyman BT, Holtzman DM. Apolipoprotein E levels and Alzheimer risk. Annals of Neurology. 77: 204-5. PMID 25583643 DOI: 10.1002/ana.24355  0.44
2015 Aschenbrenner AJ, Balota DA, Tse CS, Fagan AM, Holtzman DM, Benzinger TL, Morris JC. Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: Synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults. Neuropsychology. 29: 368-81. PMID 25222200 DOI: 10.1037/neu0000133  1
2015 Liao F, Zhang TJ, Mahan TE, Jiang H, Holtzman DM. Effects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model. Brain, Behavior, and Immunity. 47: 163-71. PMID 25218899 DOI: 10.1016/j.bbi.2014.09.005  1
2015 Roh JH, Holtzman DM. Is there a link between the sleep-wake cycle and Alzheimer's pathology? Future Neurology. 10: 183-186. DOI: 10.2217/fnl.15.15  1
2015 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Joy Snider B, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Correction to Potential role of orexin and sleep modulation in the pathogenesis of alzheimer's disease [The Journal of Experimental Medicine, 211, 13, (2014), 2487-2496] Journal of Experimental Medicine. 212: 121. DOI: 10.1084/jem.2014178812122014c  0.4
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1: 339-348. DOI: 10.1016/j.dadm.2015.06.008  0.6
2014 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. The Journal of Experimental Medicine. 211: 2487-96. PMID 25422493 DOI: 10.1084/jem.20141788  1
2014 Lim MM, Gerstner JR, Holtzman DM. The sleep-wake cycle and Alzheimer's disease: what do we know? Neurodegenerative Disease Management. 4: 351-62. PMID 25405649 DOI: 10.2217/nmt.14.33  0.6
2014 Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, ... ... Holtzman DM, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/journal.pgen.1004758  1
2014 Dikranian K, Holtzman DM. The Ultrastructural Identity of Alzheimer's Pathology: Lessons from Animal Models. Journal of Neurological Disorders. 2: e111. PMID 25309943 DOI: 10.4172/2329-6895.1000e111  0.52
2014 Liao F, Holtzman DM. Human neurons derived from induced pluripotent stem cells as a new platform for preclinical drug screening and development. Jama Neurology. 71: 1475-6. PMID 25285675 DOI: 10.1001/jamaneurol.2014.2802  1
2014 Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI. Proteopathic tau seeding predicts tauopathy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: E4376-85. PMID 25261551 DOI: 10.1073/pnas.1411649111  1
2014 Garai K, Verghese PB, Baban B, Holtzman DM, Frieden C. The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation. Biochemistry. 53: 6323-31. PMID 25207746 DOI: 10.1021/bi5008172  1
2014 Milner E, Zhou ML, Johnson AW, Vellimana AK, Greenberg JK, Holtzman DM, Han BH, Zipfel GJ. Cerebral amyloid angiopathy increases susceptibility to infarction after focal cerebral ischemia in Tg2576 mice. Stroke; a Journal of Cerebral Circulation. 45: 3064-9. PMID 25190447 DOI: 10.1161/STROKEAHA.114.006078  1
2014 Siemers E, Dean RA, DeMattos RB, Hutton ML, Blennow K, Shaw LM, Holtzman DM. Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014). Acta Neuropathologica. 128: 609-10. PMID 25120192 DOI: 10.1007/s00401-014-1332-9  1
2014 Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, et al. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. Jama Neurology. 71: 1111-22. PMID 25069482 DOI: 10.1001/jamaneurol.2014.1654  1
2014 Pankiewicz JE, Guridi M, Kim J, Asuni AA, Sanchez S, Sullivan PM, Holtzman DM, Sadowski MJ. Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. Acta Neuropathologica Communications. 2: 75. PMID 24972680 DOI: 10.1186/s40478-014-0075-0  0.32
2014 Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, Stewart FR, Piccio L, Colonna M, Holtzman DM. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Molecular Neurodegeneration. 9: 20. PMID 24893973 DOI: 10.1186/1750-1326-9-20  1
2014 Liao F, Hori Y, Hudry E, Bauer AQ, Jiang H, Mahan TE, Lefton KB, Zhang TJ, Dearborn JT, Kim J, Culver JP, Betensky R, Wozniak DF, Hyman BT, Holtzman DM. Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7281-92. PMID 24849360 DOI: 10.1523/JNEUROSCI.0646-14.2014  1
2014 Cavalli V, Holtzman DM. B-RAF unlocks axon regeneration. The Journal of Experimental Medicine. 211: 746. PMID 24799531 DOI: 10.1084/jem.2115insight3  1
2014 Shin S, Walz KA, Archambault AS, Sim J, Bollman BP, Koenigsknecht-Talboo J, Cross AH, Holtzman DM, Wu GF. Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis. Journal of Neuroimmunology. 271: 8-17. PMID 24794230 DOI: 10.1016/j.jneuroim.2014.03.010  1
2014 Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, ... ... Holtzman DM, et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine. 6: 226ra30. PMID 24598588 DOI: 10.1126/scitranslmed.3007901  1
2014 Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM. Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biological Psychiatry. 75: 723-31. PMID 24548642 DOI: 10.1016/j.biopsych.2013.11.032  1
2014 Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM. Neuronal activity regulates extracellular tau in vivo. The Journal of Experimental Medicine. 211: 387-93. PMID 24534188 DOI: 10.1084/jem.20131685  1
2014 Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Füchtbauer EM, Füchtbauer A, Holtzman DM, Takagi J, Willnow TE. Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Science Translational Medicine. 6: 223ra20. PMID 24523320 DOI: 10.1126/scitranslmed.3007747  1
2014 Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Holtzman DM, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/j.neurobiolaging.2013.12.010  1
2014 Ju YE, Lucey BP, Holtzman DM. Sleep and Alzheimer disease pathology--a bidirectional relationship. Nature Reviews. Neurology. 10: 115-9. PMID 24366271 DOI: 10.1038/nrneurol.2013.269  1
2014 Brier MR, Thomas JB, Fagan AM, Hassenstab J, Holtzman DM, Benzinger TL, Morris JC, Ances BM. Functional connectivity and graph theory in preclinical Alzheimer's disease. Neurobiology of Aging. 35: 757-68. PMID 24216223 DOI: 10.1016/j.neurobiolaging.2013.10.081  1
2014 Sutphen CL, Fagan AM, Holtzman DM. Progress update: fluid and imaging biomarkers in Alzheimer's disease. Biological Psychiatry. 75: 520-6. PMID 24012326 DOI: 10.1016/j.biopsych.2013.07.031  1
2013 Jack CR, Holtzman DM. Biomarker modeling of Alzheimer's disease. Neuron. 80: 1347-58. PMID 24360540 DOI: 10.1016/j.neuron.2013.12.003  1
2013 Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G. Neuronal clearance of amyloid-β by endocytic receptor LRP1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19276-83. PMID 24305823 DOI: 10.1523/JNEUROSCI.3487-13.2013  1
2013 Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, ... ... Holtzman DM, et al. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. The Journal of Clinical Investigation. 123: 5389-400. PMID 24270424 DOI: 10.1172/JCI70317  1
2013 Roe CM, Fagan AM, Grant EA, Holtzman DM, Morris JC. CSF biomarkers of Alzheimer disease: "noncognitive" outcomes. Neurology. 81: 2028-31. PMID 24212387 DOI: 10.1212/01.wnl.0000436940.78152.05  1
2013 Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17553-9. PMID 24198345 DOI: 10.1523/JNEUROSCI.3258-13.2013  1
2013 Benzinger TL, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, ... ... Holtzman DM, et al. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 110: E4502-9. PMID 24194552 DOI: 10.1073/pnas.1317918110  1
2013 Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron. 80: 402-14. PMID 24075978 DOI: 10.1016/j.neuron.2013.07.046  1
2013 Duchek JM, Balota DA, Thomas JB, Snyder AZ, Rich P, Benzinger TL, Fagan AM, Holtzman DM, Morris JC, Ances BM. Relationship between Stroop performance and resting state functional connectivity in cognitively normal older adults. Neuropsychology. 27: 516-28. PMID 24040929 DOI: 10.1037/a0033402  1
2013 Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM. Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. The Lancet. Neurology. 12: 957-65. PMID 24012374 DOI: 10.1016/S1474-4422(13)70194-7  1
2013 Benitez BA, Karch CM, Cai Y, Jin SC, Cooper B, Carrell D, Bertelsen S, Chibnik L, Schneider JA, Bennett DA, Fagan AM, Holtzman D, Morris JC, et al. The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers. Plos Genetics. 9: e1003685. PMID 23990795 DOI: 10.1371/journal.pgen.1003685  1
2013 Wang L, Brier MR, Snyder AZ, Thomas JB, Fagan AM, Xiong C, Benzinger TL, Holtzman DM, Morris JC, Ances BM. Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity. Jama Neurology. 70: 1242-8. PMID 23959173 DOI: 10.1001/jamaneurol.2013.3253  1
2013 Ju YE, Holtzman DM. Sleep evaluation by actigraphy for patients with Alzheimer disease--reply. Jama Neurology. 70: 1074-5. PMID 23939592 DOI: 10.1001/jamaneurol.2013.3490  1
2013 DeVos SL, Goncharoff DK, Chen G, Kebodeaux CS, Yamada K, Stewart FR, Schuler DR, Maloney SE, Wozniak DF, Rigo F, Bennett CF, Cirrito JR, Holtzman DM, Miller TM. Antisense reduction of tau in adult mice protects against seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12887-97. PMID 23904623 DOI: 10.1523/JNEUROSCI.2107-13.2013  1
2013 Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Science Translational Medicine. 5: 189ra77. PMID 23761040 DOI: 10.1126/scitranslmed.3005615  1
2013 Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-f. PMID 23704555 DOI: 10.1126/science.1235505  1
2013 Perrin RJ, Payton JE, Malone JP, Gilmore P, Davis AE, Xiong C, Fagan AM, Townsend RR, Holtzman DM. Quantitative label-free proteomics for discovery of biomarkers in cerebrospinal fluid: assessment of technical and inter-individual variation. Plos One. 8: e64314. PMID 23700471 DOI: 10.1371/journal.pone.0064314  1
2013 Zhang YH, Raymick J, Sarkar S, Lahiri DK, Ray B, Holtzman D, Dumas M, Schmued LC. Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease. Current Alzheimer Research. 10: 494-506. PMID 23627708 DOI: 10.2174/1567205011310050005  1
2013 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, et al. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 251-61. PMID 23622690 DOI: 10.1016/j.jalz.2013.01.010  0.64
2013 Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proceedings of the National Academy of Sciences of the United States of America. 110: E1807-16. PMID 23620513 DOI: 10.1073/pnas.1220484110  1
2013 Ulrich JD, Burchett JM, Restivo JL, Schuler DR, Verghese PB, Mahan TE, Landreth GE, Castellano JM, Jiang H, Cirrito JR, Holtzman DM. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Molecular Neurodegeneration. 8: 13. PMID 23601557 DOI: 10.1186/1750-1326-8-13  1
2013 Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, Sutphen CL, Benzinger TL, Mintun MA, Holtzman DM, Morris JC. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology. 80: 1784-91. PMID 23576620 DOI: 10.1212/WNL.0b013e3182918ca6  1
2013 Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Holtzman DM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/j.neuron.2013.02.026  1
2013 Hu WT, Holtzman D, Shaw L, Trojanowski J, Soares H. Author response. Neurology. 80: 690-1. PMID 23527399 DOI: 10.1212/01.wnl.0000427396.91304.3d  1
2013 Kuszczyk MA, Sanchez S, Pankiewicz J, Kim J, Duszczyk M, Guridi M, Asuni AA, Sullivan PM, Holtzman DM, Sadowski MJ. Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. The American Journal of Pathology. 182: 1750-68. PMID 23499462 DOI: 10.1016/j.ajpath.2013.01.034  1
2013 Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM. Sleep quality and preclinical Alzheimer disease. Jama Neurology. 70: 587-93. PMID 23479184 DOI: 10.1001/jamaneurol.2013.2334  1
2013 Dalal J, Roh JH, Maloney SE, Akuffo A, Shah S, Yuan H, Wamsley B, Jones WB, de Guzman Strong C, Gray PA, Holtzman DM, Heintz N, Dougherty JD. Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. Genes & Development. 27: 565-78. PMID 23431030 DOI: 10.1101/gad.207654.112  1
2013 Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls. Annals of Neurology. 73: 104-19. PMID 23225543 DOI: 10.1002/ana.23748  1
2013 Winer L, Srinivasan D, Chun S, Lacomis D, Jaffa M, Fagan A, Holtzman DM, Wancewicz E, Bennett CF, Bowser R, Cudkowicz M, Miller TM. SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy. Jama Neurology. 70: 201-7. PMID 23147550 DOI: 10.1001/jamaneurol.2013.593  1
2013 Kraft AW, Hu X, Yoon H, Yan P, Xiao Q, Wang Y, Gil SC, Brown J, Wilhelmsson U, Restivo JL, Cirrito JR, Holtzman DM, Kim J, Pekny M, Lee JM. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 187-98. PMID 23038755 DOI: 10.1096/fj.12-208660  1
2012 Roh JH, Holtzman DM. Stealth attack: plaque-specific antibody allows for efficient Aβ removal without side effects. Neuron. 76: 859-61. PMID 23217733 DOI: 10.1016/j.neuron.2012.11.018  1
2012 Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, et al. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical Investigation. 2: 975-984. PMID 23139856 DOI: 10.4155/cli.12.93  0.6
2012 Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis. The Journal of Experimental Medicine. 209: 2149-56. PMID 23129750 DOI: 10.1084/jem.20121274  1
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/JNEUROSCI.1542-12.2012  1
2012 Musiek ES, Holtzman DM. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current Opinion in Neurology. 25: 715-20. PMID 23041958 DOI: 10.1097/WCO.0b013e32835a30f4  1
2012 Xiao Q, Ford AL, Xu J, Yan P, Lee KY, Gonzales E, West T, Holtzman DM, Lee JM. Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13587-96. PMID 23015448 DOI: 10.1523/JNEUROSCI.2617-12.2012  1
2012 Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ, Holtzman DM. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology. Science Translational Medicine. 4: 150ra122. PMID 22956200 DOI: 10.1126/scitranslmed.3004291  1
2012 Dikranian K, Kim J, Stewart FR, Levy MA, Holtzman DM. Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease. International Journal of Clinical and Experimental Pathology. 5: 482-95. PMID 22949930  1
2012 Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 15502-7. PMID 22927427 DOI: 10.1073/pnas.1206446109  1
2012 Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology. 79: 897-905. PMID 22855860 DOI: 10.1212/WNL.0b013e318266fa70  1
2012 Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human Molecular Genetics. 21: 4558-71. PMID 22821396 DOI: 10.1093/hmg/dds296  1
2012 Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. The New England Journal of Medicine. 367: 795-804. PMID 22784036 DOI: 10.1056/NEJMoa1202753  1
2012 Brier MR, Thomas JB, Snyder AZ, Benzinger TL, Zhang D, Raichle ME, Holtzman DM, Morris JC, Ances BM. Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8890-9. PMID 22745490 DOI: 10.1523/JNEUROSCI.5698-11.2012  1
2012 Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Research. 1467: 120-32. PMID 22682924 DOI: 10.1016/j.brainres.2012.05.048  1
2012 Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, ... Holtzman DM, et al. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. Plos One. 7: e38013. PMID 22675504 DOI: 10.1371/journal.pone.0038013  1
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/brain/aws127  1
2012 Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 485: 512-6. PMID 22622580 DOI: 10.1038/nature11087  1
2012 Tarawneh R, Holtzman DM. The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment. Cold Spring Harbor Perspectives in Medicine. 2: a006148. PMID 22553492 DOI: 10.1101/cshperspect.a006148  1
2012 Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Sohrabi HR, Martins RN, Gandy S, Urakami K, Suzuki T. Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Molecular Neurodegeneration. 7: 16. PMID 22534039 DOI: 10.1186/1750-1326-7-16  1
2012 Portelius E, Zetterberg H, Dean RA, Marcil A, Bourgeois P, Nutu M, Andreasson U, Siemers E, Mawuenyega KG, Sigurdson WC, May PC, Paul SM, Holtzman DM, Blennow K, Bateman RJ. Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 335-41. PMID 22531418 DOI: 10.3233/JAD-2012-120508  1
2012 Holtzman DM. CSF biomarkers for secondary prevention trials: why markers of amyloid deposition and neurodegeneration are both important. Archives of Neurology. 69: 691-2. PMID 22529246 DOI: 10.1001/archneurol.2012.587  1
2012 Basak JM, Kim J, Pyatkivskyy Y, Wildsmith KR, Jiang H, Parsadanian M, Patterson BW, Bateman RJ, Holtzman DM. Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling. Molecular Neurodegeneration. 7: 14. PMID 22512932 DOI: 10.1186/1750-1326-7-14  1
2012 Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. Trans-cellular propagation of Tau aggregation by fibrillar species. The Journal of Biological Chemistry. 287: 19440-51. PMID 22461630 DOI: 10.1074/jbc.M112.346072  1
2012 Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM. Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4334-40. PMID 22457485 DOI: 10.1523/JNEUROSCI.5845-11.2012  1
2012 McDonald JM, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM. The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain. Brain Research. 1450: 138-47. PMID 22440675 DOI: 10.1016/j.brainres.2012.02.041  1
2012 Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a006312. PMID 22393530 DOI: 10.1101/cshperspect.a006312  1
2012 Basak JM, Verghese PB, Yoon H, Kim J, Holtzman DM. Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. The Journal of Biological Chemistry. 287: 13959-71. PMID 22383525 DOI: 10.1074/jbc.M111.288746  1
2012 Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM. CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease. Neurology. 78: 709-19. PMID 22357717 DOI: 10.1212/WNL.0b013e318248e568  1
2012 Storandt M, Head D, Fagan AM, Holtzman DM, Morris JC. Toward a multifactorial model of Alzheimer disease. Neurobiology of Aging. 33: 2262-71. PMID 22261556 DOI: 10.1016/j.neurobiolaging.2011.11.029  1
2012 Ances BM, Benzinger TL, Christensen JJ, Thomas J, Venkat R, Teshome M, Aldea P, Fagan AM, Holtzman DM, Morris JC, Clifford DB. 11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder. Archives of Neurology. 69: 72-7. PMID 22232345 DOI: 10.1001/archneurol.2011.761  1
2012 Head D, Bugg JM, Goate AM, Fagan AM, Mintun MA, Benzinger T, Holtzman DM, Morris JC. Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. Archives of Neurology. 69: 636-43. PMID 22232206 DOI: 10.1001/archneurol.2011.845  1
2012 Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, ... ... Holtzman DM, et al. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nature Medicine. 18: 153-8. PMID 22179319 DOI: 10.1038/nm.2558  1
2012 Wang L, Fagan AM, Shah AR, Beg MF, Csernansky JG, Morris JC, Holtzman DM. Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type. Alzheimer Disease and Associated Disorders. 26: 314-21. PMID 22156755 DOI: 10.1097/WAD.0b013e31823c0cf4  1
2012 Magnoni S, Esparza TJ, Conte V, Carbonara M, Carrabba G, Holtzman DM, Zipfel GJ, Stocchetti N, Brody DL. Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury. Brain : a Journal of Neurology. 135: 1268-80. PMID 22116192 DOI: 10.1093/brain/awr286  1
2011 Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer's disease. Science Translational Medicine. 3: 114ps48. PMID 22190237 DOI: 10.1126/scitranslmed.3003529  1
2011 Kim J, Jiang H, Park S, Eltorai AE, Stewart FR, Yoon H, Basak JM, Finn MB, Holtzman DM. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18007-12. PMID 22159114 DOI: 10.1523/JNEUROSCI.3773-11.2011  1
2011 Legleiter J, Fryer JD, Holtzman DM, Kowalewski A. The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption. Acs Chemical Neuroscience. 2: 588-599. PMID 22125665 DOI: 10.1021/cn2000475  1
2011 Holtzman DM. CSF biomarkers for Alzheimer's disease: current utility and potential future use. Neurobiology of Aging. 32: S4-9. PMID 22078172 DOI: 10.1016/j.neurobiolaging.2011.09.003  1
2011 Verghese PB, Sasaki Y, Yang D, Stewart F, Sabar F, Finn MB, Wroge CM, Mennerick S, Neil JJ, Milbrandt J, Holtzman DM. Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death. Proceedings of the National Academy of Sciences of the United States of America. 108: 19054-9. PMID 22058226 DOI: 10.1073/pnas.1107325108  1
2011 Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15861-9. PMID 22049429 DOI: 10.1523/JNEUROSCI.3272-11.2011  1
2011 Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13110-7. PMID 21917794 DOI: 10.1523/JNEUROSCI.2569-11.2011  1
2011 Roe CM, Fagan AM, Grant EA, Marcus DS, Benzinger TL, Mintun MA, Holtzman DM, Morris JC. Cerebrospinal fluid biomarkers, education, brain volume, and future cognition. Archives of Neurology. 68: 1145-51. PMID 21911695 DOI: 10.1001/archneurol.2011.192  1
2011 Cruchaga C, Nowotny P, Kauwe JS, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of Neurology. 68: 1013-9. PMID 21825236 DOI: 10.1001/archneurol.2011.155  1
2011 Tarawneh R, D'Angelo G, Macy E, Xiong C, Carter D, Cairns NJ, Fagan AM, Head D, Mintun MA, Ladenson JH, Lee JM, Morris JC, Holtzman DM. Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease. Annals of Neurology. 70: 274-85. PMID 21823155 DOI: 10.1002/ana.22448  1
2011 Verges DK, Restivo JL, Goebel WD, Holtzman DM, Cirrito JR. Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11328-37. PMID 21813692 DOI: 10.1523/JNEUROSCI.0607-11.2011  1
2011 Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Holtzman DM, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/j.jalz.2011.05.2243  1
2011 Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/scitranslmed.3002156  1
2011 Tran HT, LaFerla FM, Holtzman DM, Brody DL. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9513-25. PMID 21715616 DOI: 10.1523/JNEUROSCI.0858-11.2011  1
2011 Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, ... ... Holtzman DM, et al. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Annals of Neurology. 69: 1026-31. PMID 21681798 DOI: 10.1002/ana.22343  1
2011 Lim MM, Xu J, Holtzman DM, Mach RH. Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum. Neuroreport. 22: 489-93. PMID 21642879 DOI: 10.1097/WNR.0b013e32834846a0  1
2011 Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7049-59. PMID 21562267 DOI: 10.1523/JNEUROSCI.6546-10.2011  1
2011 Fagan AM, Shaw LM, Xiong C, Vanderstichele H, Mintun MA, Trojanowski JQ, Coart E, Morris JC, Holtzman DM. Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology. Archives of Neurology. 68: 1137-44. PMID 21555603 DOI: 10.1001/archneurol.2011.105  1
2011 Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM. Neuronal activity regulates the regional vulnerability to amyloid-β deposition. Nature Neuroscience. 14: 750-6. PMID 21532579 DOI: 10.1038/nn.2801  1
2011 Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, Perrin RJ, Bales KR, Soares H, Fagan AM, Holtzman DM. Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis. Plos One. 6: e18850. PMID 21526197 DOI: 10.1371/journal.pone.0018850  1
2011 Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 270-9. PMID 21514249 DOI: 10.1016/j.jalz.2011.03.008  1
2011 Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Science Translational Medicine. 3: 77sr1. PMID 21471435 DOI: 10.1126/scitranslmed.3002369  0.6
2011 Lodygensky GA, West T, Moravec MD, Back SA, Dikranian K, Holtzman DM, Neil JJ. Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 66: 839-45. PMID 21394776 DOI: 10.1002/mrm.22869  1
2011 Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet. Neurology. 10: 241-52. PMID 21349439 DOI: 10.1016/S1474-4422(10)70325-2  1
2011 Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Plos One. 6: e15918. PMID 21347408 DOI: 10.1371/journal.pone.0015918  1
2011 Pasic MD, Diamandis EP, McLaurin J, Holtzman DM, Schmitt-Ulms G, Quirion R. Alzheimer disease: advances in pathogenesis, diagnosis, and therapy. Clinical Chemistry. 57: 664-9. PMID 21310870 DOI: 10.1373/clinchem.2011.161828  1
2011 Perrin RJ, Craig-Schapiro R, Malone JP, Shah AR, Gilmore P, Davis AE, Roe CM, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, Kaye JA, Morris JC, Holtzman DM, et al. Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease. Plos One. 6: e16032. PMID 21264269 DOI: 10.1371/journal.pone.0016032  1
2011 Roe CM, Fagan AM, Williams MM, Ghoshal N, Aeschleman M, Grant EA, Marcus DS, Mintun MA, Holtzman DM, Morris JC. Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease. Neurology. 76: 501-10. PMID 21228296 DOI: 10.1212/WNL.0b013e31820af900  0.6
2011 Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 775-84. PMID 21059748 DOI: 10.1096/fj.10-167213  1
2011 Elbert DL, Patterson BW, Ercole L, Ovod V, Kasten T, Mawuenyega K, Yarasheski K, Morris JC, Benzinger T, Holtzman DM, Bateman RJ. Reply to: Fractional synthesis and clearance rates for amyloid β Nature Medicine. 17: 1179-1180. DOI: 10.1038/nm.2496  1
2011 Basak JM, Holtzman DM. APP-based transgenic models: The PDAPP model Neuromethods. 48: 371-385. DOI: 10.1007/978-1-60761-898-0_18  1
2010 Kim J, Holtzman DM. Medicine. Prion-like behavior of amyloid-beta. Science (New York, N.Y.). 330: 918-9. PMID 21071652 DOI: 10.1126/science.1198314  1
2010 Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D'Angelo G, Malone JP, Townsend RR, ... ... Holtzman DM, et al. YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biological Psychiatry. 68: 903-12. PMID 21035623 DOI: 10.1016/j.biopsych.2010.08.025  1
2010 Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, ... ... Holtzman DM, et al. SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. Plos Genetics. 6: e1001101. PMID 20862329 DOI: 10.1371/journal.pgen.1001101  1
2010 Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC. Relationship of dementia screening tests with biomarkers of Alzheimer's disease. Brain : a Journal of Neurology. 133: 3290-300. PMID 20823087 DOI: 10.1093/brain/awq204  1
2010 Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of Neurology. 68: 311-8. PMID 20818789 DOI: 10.1002/ana.22096  1
2010 Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL. Traumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact study. Neurobiology of Disease. 40: 555-64. PMID 20682338 DOI: 10.1016/j.nbd.2010.06.018  1
2010 Satoh A, Brace CS, Ben-Josef G, West T, Wozniak DF, Holtzman DM, Herzog ED, Imai S. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10220-32. PMID 20668205 DOI: 10.1523/JNEUROSCI.1385-10.2010  1
2010 Kauwe JS, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's Disease : Jad. 21: 833-42. PMID 20634593 DOI: 10.3233/JAD-2010-091711  1
2010 Ances BM, Christensen JJ, Teshome M, Taylor J, Xiong C, Aldea P, Fagan AM, Holtzman DM, Morris JC, Mintun MA, Clifford DB. Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study. Neurology. 75: 111-5. PMID 20534887 DOI: 10.1212/WNL.0b013e3181e7b66e  1
2010 Tarawneh R, Holtzman DM. Biomarkers in translational research of Alzheimer's disease. Neuropharmacology. 59: 310-22. PMID 20394760 DOI: 10.1016/j.neuropharm.2010.04.006  1
2010 Dietrich HH, Xiang C, Han BH, Zipfel GJ, Holtzman DM. Soluble amyloid-beta, effect on cerebral arteriolar regulation and vascular cells. Molecular Neurodegeneration. 5: 15. PMID 20388225 DOI: 10.1186/1750-1326-5-15  1
2010 Goate A, Holtzman DM. Biomarkers will revolutionize the way we diagnose and treat Alzheimer's disease. Biomarkers in Medicine. 4: 1-2. PMID 20387300 DOI: 10.2217/bmm.10.3  1
2010 Fagan AM, Holtzman DM. Cerebrospinal fluid biomarkers of Alzheimer's disease. Biomarkers in Medicine. 4: 51-63. PMID 20361010 DOI: 10.2217/BMM.09.83  1
2010 Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of Neurology. 67: 122-31. PMID 20186853 DOI: 10.1002/ana.21843  1
2010 Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH. Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system. Brain Research. 1319: 21-32. PMID 20064490 DOI: 10.1016/j.brainres.2009.12.092  1
2010 Zeng LH, Bero AW, Zhang B, Holtzman DM, Wong M. Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex. Neurobiology of Disease. 37: 764-71. PMID 20045054 DOI: 10.1016/j.nbd.2009.12.020  1
2010 Lodygensky GA, West T, Stump M, Holtzman DM, Inder TE, Neil JJ. In vivo MRI analysis of an inflammatory injury in the developing brain. Brain, Behavior, and Immunity. 24: 759-67. PMID 19945527 DOI: 10.1016/j.bbi.2009.11.005  1
2010 Hinrichs AL, Mintun MA, Head D, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease. Biological Psychiatry. 67: 581-3. PMID 19892322 DOI: 10.1016/j.biopsych.2009.09.012  1
2010 Cheng H, Zhou Y, Holtzman DM, Han X. Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease. Neurobiology of Aging. 31: 1188-96. PMID 18762354 DOI: 10.1016/j.neurobiolaging.2008.07.020  1
2010 Bateman RJ, Siemers ER, Mawuenyega KG, Sigurdson WC, Yarasheski KE, Friedrich SW, DeMattos RB, May PC, Paul SM, Holtzman DM. Reply Annals of Neurology. 67: 144-145. DOI: 10.1002/ana.21930  1
2009 Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC, Holtzman DM. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. Embo Molecular Medicine. 1: 371-80. PMID 20049742 DOI: 10.1002/emmm.200900048  1
2009 Holtzman DM. A surrogate marker for Abeta42 production in the CNS. Embo Molecular Medicine. 1: 195-7. PMID 20049720 DOI: 10.1002/emmm.200900030  1
2009 Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration. 4: 51. PMID 20017949 DOI: 10.1186/1750-1326-4-51  1
2009 Cairns NJ, Ikonomovic MD, Benzinger T, Storandt M, Fagan AM, Shah AR, Reinwald LT, Carter D, Felton A, Holtzman DM, Mintun MA, Klunk WE, Morris JC. Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report. Archives of Neurology. 66: 1557-62. PMID 20008664 DOI: 10.1001/archneurol.2009.279  1
2009 Holtzman DM. Cerebrospinal fluid beta-amyloid 42, Tau, and P-tau: confirmation now realization. Archives of Neurology. 66: 1552-3. PMID 20008662 DOI: 10.1001/archneurol.2009.270  1
2009 Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Archives of Neurology. 66: 1469-75. PMID 20008650 DOI: 10.1001/archneurol.2009.269  1
2009 Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 64: 632-44. PMID 20005821 DOI: 10.1016/j.neuron.2009.11.013  1
2009 Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JS. CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease. Neurology. 73: 1982-7. PMID 19907013 DOI: 10.1212/WNL.0b013e3181c5b445  1
2009 Duchek JM, Balota DA, Tse CS, Holtzman DM, Fagan AM, Goate AM. The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease. Neuropsychology. 23: 746-58. PMID 19899833 DOI: 10.1037/a0016583  1
2009 Perrin RJ, Fagan AM, Holtzman DM. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature. 461: 916-22. PMID 19829371 DOI: 10.1038/nature08538  1
2009 Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science (New York, N.Y.). 326: 1005-7. PMID 19779148 DOI: 10.1126/science.1180962  1
2009 Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee JM. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10706-14. PMID 19710322 DOI: 10.1523/JNEUROSCI.2637-09.2009  1
2009 Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron. 63: 287-303. PMID 19679070 DOI: 10.1016/j.neuron.2009.06.026  1
2009 Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. Acs Chemical Biology. 4: 673-84. PMID 19624097 DOI: 10.1021/cb900112v  1
2009 Cao C, Cirrito JR, Lin X, Wang L, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H. Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice. Journal of Alzheimer's Disease : Jad. 17: 681-97. PMID 19581723 DOI: 10.3233/JAD-2009-1071  1
2009 Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, et al. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 12145-50. PMID 19581601 DOI: 10.1073/pnas.0904866106  1
2009 West T, Stump M, Lodygensky G, Neil JJ, Deshmukh M, Holtzman DM. Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury. Asn Neuro. 1. PMID 19570023 DOI: 10.1042/AN20090005  1
2009 Yuede CM, Zimmerman SD, Dong H, Kling MJ, Bero AW, Holtzman DM, Timson BF, Csernansky JG. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of Disease. 35: 426-32. PMID 19524672 DOI: 10.1016/j.nbd.2009.06.002  1
2009 Snider BJ, Fagan AM, Roe C, Shah AR, Grant EA, Xiong C, Morris JC, Holtzman DM. Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type. Archives of Neurology. 66: 638-45. PMID 19433664 DOI: 10.1001/archneurol.2009.55  1
2009 Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, Demattos RB, May PC, Paul SM, Holtzman DM. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Annals of Neurology. 66: 48-54. PMID 19360898 DOI: 10.1002/ana.21623  1
2009 Tarawneh R, Holtzman DM. Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention. Cns & Neurological Disorders Drug Targets. 8: 144-59. PMID 19355934 DOI: 10.2174/187152709787847324  1
2009 Mandrekar S, Jiang Q, Lee CY, Koenigsknecht-Talboo J, Holtzman DM, Landreth GE. Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4252-62. PMID 19339619 DOI: 10.1523/JNEUROSCI.5572-08.2009  1
2009 Fagan AM, Head D, Shah AR, Marcus D, Mintun M, Morris JC, Holtzman DM. Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly. Annals of Neurology. 65: 176-83. PMID 19260027 DOI: 10.1002/ana.21559  1
2009 Craig-Schapiro R, Fagan AM, Holtzman DM. Biomarkers of Alzheimer's disease. Neurobiology of Disease. 35: 128-40. PMID 19010417 DOI: 10.1016/j.nbd.2008.10.003  1
2009 Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate AM. Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics. 10: 13-7. PMID 18813964 DOI: 10.1007/s10048-008-0150-4  1
2009 Brody DL, Magnoni S, Schwetye KE, Spinner M, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM. Amyloid-β dynamics correlate with neurological status in the injured human brain 3rd International Conference On Bioinformatics and Biomedical Engineering, Icbbe 2009. DOI: 10.1109/ICBBE.2009.5162305  1
2008 Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14156-64. PMID 19109498 DOI: 10.1523/JNEUROSCI.4147-08.2008  1
2008 Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ. Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13542-50. PMID 19074028 DOI: 10.1523/JNEUROSCI.4686-08.2008  1
2008 Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. The Journal of Clinical Investigation. 118: 4002-13. PMID 19033669 DOI: 10.1172/JCI36663  1
2008 Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry. 283: 34554-62. PMID 18940800 DOI: 10.1074/jbc.M801487200  1
2008 Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM. Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science (New York, N.Y.). 321: 1221-4. PMID 18755980 DOI: 10.1126/science.1161591  1
2008 Maysinger D, Holmes M, Han X, Epand RM, Pertens E, Foerster A, Barlas C, Holtzman DM, Diamond J. Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7891-9. PMID 18667621 DOI: 10.1523/JNEUROSCI.1461-08.2008  1
2008 Holtzman DM. Alzheimer's disease: Moving towards a vaccine. Nature. 454: 418-20. PMID 18650906 DOI: 10.1038/454418a  1
2008 Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron. 58: 681-93. PMID 18549781 DOI: 10.1016/j.neuron.2008.04.010  1
2008 Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM, Holtzman DM, Goate AM. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition. Proceedings of the National Academy of Sciences of the United States of America. 105: 8050-4. PMID 18541914 DOI: 10.1073/pnas.0801227105  1
2008 Wendland MF, Faustino J, West T, Manabat C, Holtzman DM, Vexler ZS. Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents. Stroke; a Journal of Cerebral Circulation. 39: 1862-8. PMID 18420950 DOI: 10.1161/STROKEAHA.107.506352  1
2008 Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron. 58: 42-51. PMID 18400162 DOI: 10.1016/j.neuron.2008.02.003  1
2008 Brody DL, Holtzman DM. Active and passive immunotherapy for neurodegenerative disorders. Annual Review of Neuroscience. 31: 175-93. PMID 18352830 DOI: 10.1146/annurev.neuro.31.060407.125529  1
2008 Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 451: 720-4. PMID 18256671 DOI: 10.1038/nature06616  1
2008 Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 671-82. PMID 18202749 DOI: 10.1172/JCI33622  1
2008 Wippold FJ, Cairns N, Vo K, Holtzman DM, Morris JC. Neuropathology for the neuroradiologist: plaques and tangles. Ajnr. American Journal of Neuroradiology. 29: 18-22. PMID 17925367 DOI: 10.3174/ajnr.A0781  0.6
2007 Hu Y, Hosseini A, Kauwe JS, Gross J, Cairns NJ, Goate AM, Fagan AM, Townsend RR, Holtzman DM. Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease. Proteomics. Clinical Applications. 1: 1373-84. PMID 21136637 DOI: 10.1002/prca.200600999  1
2007 West T, Atzeva M, Holtzman DM. Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury. Developmental Neuroscience. 29: 363-72. PMID 17762204 DOI: 10.1159/000105477  1
2007 Zeng LH, Ouyang Y, Gazit V, Cirrito JR, Jansen LA, Ess KC, Yamada KA, Wozniak DF, Holtzman DM, Gutmann DH, Wong M. Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiology of Disease. 28: 184-96. PMID 17714952 DOI: 10.1016/j.nbd.2007.07.015  1
2007 Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/ajpath.2007.070105  1
2007 Gelfanova V, Higgs RE, Dean RA, Holtzman DM, Farlow MR, Siemers ER, Boodhoo A, Qian YW, He X, Jin Z, Fisher DL, Cox KL, Hale JE. Quantitative analysis of amyloid-beta peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry. Briefings in Functional Genomics & Proteomics. 6: 149-58. PMID 17584762 DOI: 10.1093/bfgp/elm010  1
2007 Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM. Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 104: 10673-8. PMID 17551018 DOI: 10.1073/pnas.0700148104  1
2007 Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury. Journal of Neurotrauma. 24: 657-73. PMID 17439349 DOI: 10.1089/neu.2006.0011  1
2007 Wahrle SE, Shah AR, Fagan AM, Smemo S, Kauwe JS, Grupe A, Hinrichs A, Mayo K, Jiang H, Thal LJ, Goate AM, Holtzman DM. Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Molecular Neurodegeneration. 2: 7. PMID 17430597 DOI: 10.1186/1750-1326-2-7  1
2007 Bateman RJ, Munsell LY, Chen X, Holtzman DM, Yarasheski KE. Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates. Journal of the American Society For Mass Spectrometry. 18: 997-1006. PMID 17383190 DOI: 10.1016/j.jasms.2007.02.009  0.6
2007 Mac Donald CL, Dikranian K, Song SK, Bayly PV, Holtzman DM, Brody DL. Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. Experimental Neurology. 205: 116-31. PMID 17368446 DOI: 10.1016/j.expneurol.2007.01.035  1
2007 Kauwe JS, Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM. Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation. Annals of Neurology. 61: 446-53. PMID 17366635 DOI: 10.1002/ana.21099  1
2007 Bateman RJ, Wen G, Morris JC, Holtzman DM. Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker. Neurology. 68: 666-9. PMID 17325273 DOI: 10.1212/01.wnl.0000256043.50901.e3  0.6
2007 Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Archives of Neurology. 64: 343-9. PMID 17210801 DOI: 10.1001/archneur.64.3.noc60123  0.6
2007 Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 909-18. PMID 17077814 DOI: 10.1038/sj.jcbfm.9600419  1
2006 Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, et al. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Bmc Neurology. 6: 44. PMID 17166276 DOI: 10.1186/1471-2377-6-44  1
2006 Csernansky JG, Dong H, Fagan AM, Wang L, Xiong C, Holtzman DM, Morris JC. Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. The American Journal of Psychiatry. 163: 2164-9. PMID 17151169 DOI: 10.1176/appi.ajp.163.12.2164  1
2006 Oe T, Ackermann BL, Inoue K, Berna MJ, Garner CO, Gelfanova V, Dean RA, Siemers ER, Holtzman DM, Farlow MR, Blair IA. Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 20: 3723-35. PMID 17117458 DOI: 10.1002/rcm.2787  1
2006 Yin KJ, Cirrito JR, Yan P, Hu X, Xiao Q, Pan X, Bateman R, Song H, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, Lee JM. Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10939-48. PMID 17065436 DOI: 10.1523/JNEUROSCI.2085-06.2006  1
2006 Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. The Journal of Biological Chemistry. 281: 36180-6. PMID 17012232 DOI: 10.1074/jbc.M604436200  1
2006 Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, Finn MB, Holtzman DM. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiology of Disease. 24: 506-15. PMID 17010630 DOI: 10.1016/j.nbd.2006.08.006  1
2006 Schlief ML, West T, Craig AM, Holtzman DM, Gitlin JD. Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Proceedings of the National Academy of Sciences of the United States of America. 103: 14919-24. PMID 17003121 DOI: 10.1073/pnas.0605390103  1
2006 Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, Vinters HV, Holtzman DM, Rosenberg GA, Wallin A, Dichgans M, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke; a Journal of Cerebral Circulation. 37: 2220-41. PMID 16917086 DOI: 10.1161/01.STR.0000237236.88823.47  1
2006 Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nature Medicine. 12: 856-61. PMID 16799555 DOI: 10.1038/nm1438  0.6
2006 Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, Xiao Q, Hsu FF, Turk JW, Xu J, Hsu CY, Holtzman DM, Lee JM. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. The Journal of Biological Chemistry. 281: 24566-74. PMID 16787929 DOI: 10.1074/jbc.M602440200  1
2006 Brendza RP, Holtzman DM. Amyloid-beta immunotherapies in mice and men. Alzheimer Disease and Associated Disorders. 20: 118-23. PMID 16772748 DOI: 10.1097/01.wad.0000213810.89681.a5  0.44
2006 Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease. Neurology. 66: 602-4. PMID 16505324 DOI: 10.1212/01.WNL.0000198762.41312.E1  1
2006 West T, Atzeva M, Holtzman DM. Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways. Neurobiology of Disease. 22: 523-37. PMID 16480886 DOI: 10.1016/j.nbd.2005.12.017  1
2006 Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Annals of Neurology. 59: 512-9. PMID 16372280 DOI: 10.1002/ana.20730  1
2006 Wei L, Han BH, Li Y, Keogh CL, Holtzman DM, Yu SP. Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. The Journal of Pharmacology and Experimental Therapeutics. 317: 109-16. PMID 16357210 DOI: 10.1124/jpet.105.094391  0.68
2006 Brody DL, Holtzman DM. Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Experimental Neurology. 197: 330-40. PMID 16309676 DOI: 10.1016/j.expneurol.2005.10.020  1
2005 Morris JC, Kimberly A, Quaid K, Holtzman DM, Kantarci K, Kaye J, Reiman EM, Klunk WE, Siemers ER. Role of biomarkers in studies of presymptomatic Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 145-51. PMID 19595847 DOI: 10.1016/j.jalz.2005.09.013  0.6
2005 Fagan AM, Csernansky CA, Morris JC, Holtzman DM. The search for antecedent biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 8: 347-58. PMID 16556966  0.6
2005 Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron. 48: 913-22. PMID 16364896 DOI: 10.1016/j.neuron.2005.10.028  1
2005 Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11495-503. PMID 16354907 DOI: 10.1523/JNEUROSCI.3697-05.2005  1
2005 Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 115: 3285-90. PMID 16239972 DOI: 10.1172/JCI25247  1
2005 Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. The Journal of Biological Chemistry. 280: 43236-42. PMID 16207708 DOI: 10.1074/jbc.M508780200  1
2005 Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM. Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Molecular & Cellular Proteomics : McP. 4: 2000-9. PMID 16199891 DOI: 10.1074/mcp.M500207-MCP200  1
2005 Fryer JD, Holtzman DM. The bad seed in Alzheimer's disease. Neuron. 47: 167-8. PMID 16039556 DOI: 10.1016/j.neuron.2005.07.002  1
2005 Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6213-20. PMID 15987951 DOI: 10.1523/JNEUROSCI.0664-05.2005  1
2005 Young C, Roth KA, Klocke BJ, West T, Holtzman DM, Labruyere J, Qin YQ, Dikranian K, Olney JW. Role of caspase-3 in ethanol-induced developmental neurodegeneration. Neurobiology of Disease. 20: 608-14. PMID 15927478 DOI: 10.1016/j.nbd.2005.04.014  1
2005 Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. The Journal of Biological Chemistry. 280: 25754-9. PMID 15888448 DOI: 10.1074/jbc.M502143200  1
2005 Morikawa M, Fryer JD, Sullivan PM, Christopher EA, Wahrle SE, DeMattos RB, O'Dell MA, Fagan AM, Lashuel HA, Walz T, Asai K, Holtzman DM. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiology of Disease. 19: 66-76. PMID 15837562 DOI: 10.1016/j.nbd.2004.11.005  1
2005 Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatric Research. 57: 858-64. PMID 15774834 DOI: 10.1203/01.PDR.0000157722.07810.15  1
2005 Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2803-10. PMID 15772340 DOI: 10.1523/JNEUROSCI.5170-04.2005  1
2005 Lee JM, Yin K, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J. Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. Journal of the Neurological Sciences. 229: 249-54. PMID 15760647 DOI: 10.1016/j.jns.2004.11.041  1
2005 Maas JW, Indacochea RA, Muglia LM, Tran TT, Vogt SK, West T, Benz A, Shute AA, Holtzman DM, Mennerick S, Olney JW, Muglia LJ. Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2376-85. PMID 15745964 DOI: 10.1523/JNEUROSCI.4940-04.2005  1
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/JCI23269  1
2005 Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, Piroozi KS, Jordan WH, Brown DD, Hoffman WP, Holtzman DM, Bales KR, Gitter BD, May PC, Paul SM, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 629-36. PMID 15659599 DOI: 10.1523/JNEUROSCI.4337-04.2005  1
2005 Sun SW, Song SK, Harms MP, Lin SJ, Holtzman DM, Merchant KM, Kotyk JJ. Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging. Experimental Neurology. 191: 77-85. PMID 15589514 DOI: 10.1016/j.expneurol.2004.09.006  1
2004 Wei X, Zhao L, Ma Z, Holtzman DM, Yan C, Dodel RC, Hampel H, Oertel W, Farlow MR, Du Y. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain : a Journal of Neurology. 127: 2629-35. PMID 15469948 DOI: 10.1093/brain/awh316  1
2004 Fagan AM, Christopher E, Taylor JW, Parsadanian M, Spinner M, Watson M, Fryer JD, Wahrle S, Bales KR, Paul SM, Holtzman DM. ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. The American Journal of Pathology. 165: 1413-22. PMID 15466405  1
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. The American Journal of Pathology. 165: 937-48. PMID 15331417  1
2004 Legleiter J, DeMattos RB, Holtzman DM, Kowalewski T. In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins. Journal of Colloid and Interface Science. 278: 96-106. PMID 15313642 DOI: 10.1016/j.jcis.2004.05.009  1
2004 Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry. 90: 1011-8. PMID 15287908 DOI: 10.1111/j.1471-4159.2004.02532.x  1
2004 Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, Holtzman DM. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. The Journal of Biological Chemistry. 279: 40987-93. PMID 15269217 DOI: 10.1074/jbc.M407963200  1
2004 Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Disease and Associated Disorders. 18: 44-6. PMID 15195463 DOI: 10.1097/00002093-200401000-00009  1
2004 Song SK, Kim JH, Lin SJ, Brendza RP, Holtzman DM. Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition. Neurobiology of Disease. 15: 640-7. PMID 15056472 DOI: 10.1016/j.nbd.2003.12.003  1
2004 Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development. 125: 149-51. PMID 15037022 DOI: 10.1016/j.mad.2003.12.002  1
2004 DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron. 41: 193-202. PMID 14741101 DOI: 10.1016/S0896-6273(03)00850-X  1
2004 Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 1075-80. PMID 14732699 DOI: 10.1073/pnas.0305803101  1
2004 Legleiter J, Czilli DL, Gitter B, DeMattos RB, Holtzman DM, Kowalewski T. Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy. Journal of Molecular Biology. 335: 997-1006. PMID 14698294 DOI: 10.1016/j.jmb.2003.11.019  1
2003 Brendza RP, Simmons K, Bales KR, Paul SM, Goldberg MP, Holtzman DM. Use of YFP to study amyloid-beta associated neurite alterations in live brain slices. Neurobiology of Aging. 24: 1071-7. PMID 14643378 DOI: 10.1016/j.neurobiolaging.2003.04.008  1
2003 Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. 122: 305-15. PMID 14614898 DOI: 10.1016/j.neuroscience.2003.08.007  1
2003 Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8844-53. PMID 14523085  1
2003 Young C, Klocke BJ, Tenkova T, Choi J, Labruyere J, Qin YQ, Holtzman DM, Roth KA, Olney JW. Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death and Differentiation. 10: 1148-55. PMID 14502238 DOI: 10.1038/sj.cdd.4401277  1
2003 Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiology of Disease. 14: 10-8. PMID 13678662 DOI: 10.1016/S0969-9961(03)00044-5  1
2003 Wahrle SE, Holtzman DM. Differential metabolism of ApoE isoforms in plasma and CSF. Experimental Neurology. 183: 4-6. PMID 12957482  0.44
2003 Lee JM, Yin KJ, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J. Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Annals of Neurology. 54: 379-82. PMID 12953271 DOI: 10.1002/ana.10671  1
2003 Fryer JD, Taylor JW, DeMattos RB, Bales KR, Paul SM, Parsadanian M, Holtzman DM. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7889-96. PMID 12944519  1
2003 Cirrito JR, Holtzman DM. Amyloid beta and Alzheimer disease therapeutics: the devil may be in the details. The Journal of Clinical Investigation. 112: 321-3. PMID 12897198 DOI: 10.1172/JCI19420  1
2003 Han X, Fagan AM, Cheng H, Morris JC, Xiong C, Holtzman DM. Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia. Annals of Neurology. 54: 115-9. PMID 12838527 DOI: 10.1002/ana.10618  0.6
2003 Brendza RP, O'Brien C, Simmons K, McKeel DW, Bales KR, Paul SM, Olney JW, Sanes JR, Holtzman DM. PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures. The Journal of Comparative Neurology. 456: 375-83. PMID 12532409 DOI: 10.1002/cne.10536  1
2003 Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM, Vexler ZS. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke; a Journal of Cerebral Circulation. 34: 207-13. PMID 12511776 DOI: 10.1161/01.STR.0000047101.87575.3C  1
2003 Han X, Cheng H, Fryer JD, Fagan AM, Holtzman DM. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. The Journal of Biological Chemistry. 278: 8043-51. PMID 12501252 DOI: 10.1074/jbc.M212340200  1
2002 Bales KR, Dodart JC, DeMattos RB, Holtzman DM, Paul SM. Apolipoprotein E, amyloid, and Alzheimer disease. Molecular Interventions. 2: 363-75, 339. PMID 14993413 DOI: 10.1124/mi.2.6.363  1
2002 Hee Han B, Choi J, Holtzman DM. Evidence that p38 mitogen-activated protein kinase contributes to neonatal hypoxic-ischemic brain injury. Developmental Neuroscience. 24: 405-10. PMID 12640179  0.4
2002 Holtzman DM, Bales KR, Paul SM, DeMattos RB. Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease. Advanced Drug Delivery Reviews. 54: 1603-13. PMID 12453677  0.6
2002 Hartman RE, Laurer H, Longhi L, Bales KR, Paul SM, McIntosh TK, Holtzman DM. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10083-7. PMID 12451108  1
2002 Narita M, Holtzman DM, Fagan AM, LaDu MJ, Yu L, Han X, Gross RW, Bu G, Schwartz AL. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. Journal of Biochemistry. 132: 743-9. PMID 12417024  1
2002 DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JA, Bales KR, Paul SM, Aronow BJ, Holtzman DM. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 10843-8. PMID 12145324 DOI: 10.1073/pnas.162228299  1
2002 Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Annals of Neurology. 52: 54-61. PMID 12112047 DOI: 10.1002/ana.10242  1
2002 DeMattos RB, Bales KR, Parsadanian M, O'Dell MA, Foss EM, Paul SM, Holtzman DM. Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease. Journal of Neurochemistry. 81: 229-36. PMID 12064470 DOI: 10.1046/j.1471-4159.2002.00889.x  1
2002 Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. The Journal of Biological Chemistry. 277: 30128-36. PMID 12058036 DOI: 10.1074/jbc.M202931200  1
2002 Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiology of Disease. 9: 305-18. PMID 11950276 DOI: 10.1006/nbdi.2002.0483  1
2002 Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nature Neuroscience. 5: 452-7. PMID 11941374 DOI: 10.1038/nn842  1
2002 DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science (New York, N.Y.). 295: 2264-7. PMID 11910111 DOI: 10.1126/science.1067568  1
2002 Brendza RP, Bales KR, Paul SM, Holtzman DM. Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models. Molecular Psychiatry. 7: 132-5. PMID 11840304 DOI: 10.1038/sj.mp.4001006  0.6
2002 Back SA, Han BH, Luo NL, Chricton CA, Xanthoudakis S, Tam J, Arvin KL, Holtzman DM. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 455-63. PMID 11784790  0.4
2001 Gibson ME, Han BH, Choi J, Knudson CM, Korsmeyer SJ, Parsadanian M, Holtzman DM. BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways. Molecular Medicine (Cambridge, Mass.). 7: 644-55. PMID 11778654  1
2001 DeMattos RB, Brendza RP, Heuser JE, Kierson M, Cirrito JR, Fryer J, Sullivan PM, Fagan AM, Han X, Holtzman DM. Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice. Neurochemistry International. 39: 415-25. PMID 11578777 DOI: 10.1016/S0197-0186(01)00049-3  1
2001 Hartman RE, Wozniak DF, Nardi A, Olney JW, Sartorius L, Holtzman DM. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Experimental Neurology. 170: 326-44. PMID 11476599 DOI: 10.1006/exnr.2001.7715  1
2001 DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 8850-5. PMID 11438712 DOI: 10.1073/pnas.151261398  1
2001 Han X, Holtzman DM, McKeel DW. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. Journal of Neurochemistry. 77: 1168-80. PMID 11359882  0.44
2001 Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony JA, Aronow BJ, Holtzman DM. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nature Medicine. 7: 338-43. PMID 11231633 DOI: 10.1038/85487  1
2001 Arredondo LR, Deng C, Ratts RB, Lovett-Racke AE, Holtzman DM, Racke MK. Role of nerve growth factor in experimental autoimmune encephalomyelitis. European Journal of Immunology. 31: 625-33. PMID 11180128 DOI: 10.1002/1521-4141(200102)31:2<625::AID-IMMU625>3.0.CO;2-H  1
2000 Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. The Journal of Clinical Investigation. 106: 1489-99. PMID 11120756 DOI: 10.1172/JCI10498  1
2000 Almli CR, Levy TJ, Han BH, Shah AR, Gidday JM, Holtzman DM. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Experimental Neurology. 166: 99-114. PMID 11031087 DOI: 10.1006/exnr.2000.7492  1
2000 Ho N, Liauw JA, Blaeser F, Wei F, Hanissian S, Muglia LM, Wozniak DF, Nardi A, Arvin KL, Holtzman DM, Linden DJ, Zhuo M, Muglia LJ, Chatila TA. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6459-72. PMID 10964952  1
2000 Lendon CL, Han BH, Salimi K, Fagan AM, Behrens MI, Muller MC, Holtzman DM. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo. The European Journal of Neuroscience. 12: 2235-42. PMID 10947802  0.6
2000 Fagan AM, Younkin LH, Morris JC, Fryer JD, Cole TG, Younkin SG, Holtzman DM. Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype. Annals of Neurology. 48: 201-10. PMID 10939571 DOI: 10.1002/1531-8249(200008)48:2<201::AID-ANA10>3.0.CO;2-X  1
2000 Fagan AM, Holtzman DM. Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo. Microscopy Research and Technique. 50: 297-304. PMID 10936884 DOI: 10.1002/1097-0029(20000815)50:4<297::AID-JEMT9>3.0.CO;2-C  0.6
2000 Han BH, Holtzman DM. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5775-81. PMID 10908618  0.4
2000 Holtzman DM, Fagan AM, Mackey B, Tenkova T, Sartorius L, Paul SM, Bales K, Ashe KH, Irizarry MC, Hyman BT. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Annals of Neurology. 47: 739-47. PMID 10852539 DOI: 10.1002/1531-8249(200006)47:6<739::AID-ANA6>3.0.CO;2-8  1
1999 Dugan LL, Kim JS, Zhang Y, Bart RD, Sun Y, Holtzman DM, Gutmann DH. Differential effects of cAMP in neurons and astrocytes. Role of B-raf. The Journal of Biological Chemistry. 274: 25842-8. PMID 10464325 DOI: 10.1074/jbc.274.36.25842  1
1998 Holtzman DM, Fagan AM. Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system. Trends in Cardiovascular Medicine. 8: 250-5. PMID 14987560  0.6
1998 Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Experimental Neurology. 151: 314-25. PMID 9628766 DOI: 10.1006/exnr.1998.6818  1
1997 Schätzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB. A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. Journal of Virology. 71: 8821-31. PMID 9343242  1
1996 Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 93: 13333-8. PMID 8917591 DOI: 10.1073/pnas.93.23.13333  1
1996 Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC. Nerve growth factor and the neurotrophic factor hypothesis. Brain & Development. 18: 362-8. PMID 8891230 DOI: 10.1016/0387-7604(96)00051-4  1
1996 Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochemical Research. 21: 861-8. PMID 8873091  1
1996 Neve RL, Valletta JS, Li Y, Ventosa-Michelman M, Holtzman DM, Mobley WC. A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Research. Molecular Brain Research. 39: 185-97. PMID 8804727 DOI: 10.1016/0169-328X(96)00007-1  1
1995 Holtzman DM, Kilbridge J, Chen KS, Rabin J, Luche R, Carlson E, Epstein CJ, Mobley WC. Preliminary characterization of the central nervous system in partial trisomy 16 mice. Progress in Clinical and Biological Research. 393: 227-40. PMID 8545453  1
1995 Holtzman DM, Kilbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC. TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1567-76. PMID 7869118  1
1995 Li Y, Holtzman DM, Kromer LF, Kaplan DR, Chua-Couzens J, Clary DO, Knüsel B, Mobley WC. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2888-905. PMID 7536822  1
1994 Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC. NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiology of Disease. 1: 51-60. PMID 9216986 DOI: 10.1006/nbdi.1994.0007  1
1994 Zhou J, Holtzman DM, Weiner RI, Mobley WC. Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proceedings of the National Academy of Sciences of the United States of America. 91: 3824-8. PMID 8170995  1
1994 Chen CK, Kinsman SL, Holtzman DM, Mobley WC, Johnston MV. A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 12: 255-62. PMID 7976482 DOI: 10.1016/0736-5748(94)90072-8  1
1994 Holtzman DM, Mobley WC. Neurotrophic factors and neurologic disease. The Western Journal of Medicine. 161: 246-54. PMID 7975562  1
1994 Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B. Transgenic mouse brain histopathology resembles early Alzheimer's disease. Annals of Neurology. 35: 598-607. PMID 7513982 DOI: 10.1002/ana.410350514  1
1993 Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 43: 2668-73. PMID 8255474  1
1992 Holtzman DM, Li YW, DeArmond SJ, McKinley MP, Gage FH, Epstein CJ, Mobley WC. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proceedings of the National Academy of Sciences of the United States of America. 89: 1383-7. PMID 1741393  1
1992 Holtzman DM, Li Y, Parada LF, Kinsman S, Chen CK, Valletta JS, Zhou J, Long JB, Mobley WC. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 9: 465-78. PMID 1524827 DOI: 10.1016/0896-6273(92)90184-F  1
1992 Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC. Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Progress in Clinical and Biological Research. 379: 227-44. PMID 1409747  1
1992 Holtzman DM, Bayney RM, Li YW, Khosrovi H, Berger CN, Epstein CJ, Mobley WC. Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. The Embo Journal. 11: 619-27. PMID 1371464  1
1991 Holtzman DM, Mobley WC. Molecular studies in Alzheimer's disease. Trends in Biochemical Sciences. 16: 140-4. PMID 1877089 DOI: 10.1016/0968-0004(91)90056-2  1
1991 Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC. Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Progress in Clinical and Biological Research. 373: 189-202. PMID 1838184  1
1990 Koliatsos VE, Nauta HJ, Clatterbuck RE, Holtzman DM, Mobley WC, Price DL. Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3801-13. PMID 2269884  1
Show low-probability matches.