Richard Horn - Publications

Affiliations: 
Thomas Jefferson University 
Area:
Ion Channels
Website:
http://www.hyperexcitability.com/

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Horn R, Roux B, Ã…qvist J. Permeation redux: thermodynamics and kinetics of ion movement through potassium channels. Biophysical Journal. 106: 1859-63. PMID 24806917 DOI: 10.1016/j.bpj.2014.03.039  1
2012 Ryan MY, Maloney R, Fineberg JD, Reenan RA, Horn R. RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue. Channels (Austin, Tex.). 6: 443-52. PMID 23064203 DOI: 10.4161/chan.22314  1
2011 Horn R. Structural biology: Peering into the spark of life. Nature. 475: 305-6. PMID 21776074 DOI: 10.1038/475305a  1
2010 Horn R, Reenan R. Channels get in an HUFA: RNA editing gets them out of a jam. The Embo Journal. 29: 2097-8. PMID 20606701 DOI: 10.1038/emboj.2010.134  1
2009 Ahern CA, Eastwood AL, Dougherty DA, Horn R. An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels. The Journal of General Physiology. 134: 461-9. PMID 19917730 DOI: 10.1085/jgp.200910260  1
2009 Horn R. Uncooperative voltage sensors. The Journal of General Physiology. 133: 463-6. PMID 19398774 DOI: 10.1085/jgp.200910236  1
2009 Ingleby L, Maloney R, Jepson J, Horn R, Reenan R. Regulated RNA editing and functional epistasis in Shaker potassium channels. The Journal of General Physiology. 133: 17-27. PMID 19114634 DOI: 10.1085/jgp.200810133  1
2008 Ryan MY, Maloney R, Reenan R, Horn R. Characterization of five RNA editing sites in Shab potassium channels. Channels (Austin, Tex.). 2: 202-9. PMID 18836299  1
2008 Ahern CA, Eastwood AL, Dougherty DA, Horn R. New insights into the therapeutic inhibition of voltage-gated sodium channels. Channels (Austin, Tex.). 2: 1-3. PMID 18690056 DOI: 10.4161/chan.2.1.6007  1
2008 Ahern CA, Eastwood AL, Dougherty DA, Horn R. Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circulation Research. 102: 86-94. PMID 17967784 DOI: 10.1161/CIRCRESAHA.107.160663  1
2007 Santarelli VP, Eastwood AL, Dougherty DA, Ahern CA, Horn R. Calcium block of single sodium channels: role of a pore-lining aromatic residue. Biophysical Journal. 93: 2341-9. PMID 17545248 DOI: 10.1529/biophysj.107.106856  1
2007 Horn R. Physiology: legacy of leaky channels. Nature. 446: 32-4. PMID 17330030 DOI: 10.1038/446032a  1
2007 Santarelli VP, Eastwood AL, Dougherty DA, Horn R, Ahern CA. A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. The Journal of Biological Chemistry. 282: 8044-51. PMID 17237232 DOI: 10.1074/jbc.M611334200  1
2006 Ahern CA, Eastwood AL, Lester HA, Dougherty DA, Horn R. A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. The Journal of General Physiology. 128: 649-57. PMID 17130518 DOI: 10.1085/jgp.200609654  1
2005 Horn R. Electrifying phosphatases. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe50. PMID 16249403 DOI: 10.1126/stke.3072005pe50  1
2005 Ahern CA, Horn R. Focused electric field across the voltage sensor of potassium channels. Neuron. 48: 25-9. PMID 16202706 DOI: 10.1016/j.neuron.2005.08.020  1
2005 Ding S, Ingleby L, Ahern CA, Horn R. Investigating the putative glycine hinge in Shaker potassium channel. The Journal of General Physiology. 126: 213-26. PMID 16103276 DOI: 10.1085/jgp.200509287  1
2005 Ahern CA, Zhang JF, Wookalis MJ, Horn R. Modulation of the cardiac sodium channel NaV1.5 by Fyn, a Src family tyrosine kinase. Circulation Research. 96: 991-8. PMID 15831816 DOI: 10.1161/01.RES.0000166324.00524.dd  1
2005 Horn R. How ion channels sense membrane potential. Proceedings of the National Academy of Sciences of the United States of America. 102: 4929-30. PMID 15795366 DOI: 10.1073/pnas.0501640102  1
2004 Ahern CA, Horn R. Stirring up controversy with a voltage sensor paddle. Trends in Neurosciences. 27: 303-7. PMID 15165733 DOI: 10.1016/j.tins.2004.03.008  1
2004 Ahern CA, Horn R. Specificity of charge-carrying residues in the voltage sensor of potassium channels. The Journal of General Physiology. 123: 205-16. PMID 14769847 DOI: 10.1085/jgp.200308993  1
2004 Horn R. How S4 segments move charge. Let me count the ways. The Journal of General Physiology. 123: 1-4. PMID 14676286 DOI: 10.1085/jgp.200308975  1
2003 Brinkmeier H, Weber F, Aulkemeyer P, Wollinsky KH, Rüdel R, Cummins TR, Renganathan M, Herzog RI, Dib-Hajj SD, Waxman SG, Stys PK, Horn R. The pentapeptide QYNAD does not block voltage-gated sodium channels [4] (multiple letters) Neurology. 60: 1871-1872. PMID 12796562  1
2003 Cummins TR, Renganathan M, Stys PK, Herzog RI, Scarfo K, Horn R, Dib-Hajj SD, Waxman SG. The pentapeptide QYNAD does not block voltage-gated sodium channels. Neurology. 60: 224-9. PMID 12552035  1
2003 Ding S, Horn R. Effect of S6 tail mutations on charge movement in Shaker potassium channels. Biophysical Journal. 84: 295-305. PMID 12524283 DOI: 10.1016/S0006-3495(03)74850-4  1
2002 Horn R. Coupled movements in voltage-gated ion channels. The Journal of General Physiology. 120: 449-53. PMID 12356847 DOI: 10.1085/jgp.20028658  1
2002 Nguyen TP, Horn R. Movement and crevices around a sodium channel S3 segment. The Journal of General Physiology. 120: 419-36. PMID 12198095 DOI: 10.1085/jgp.20028636  1
2002 Ding S, Horn R. Tail end of the s6 segment: role in permeation in shaker potassium channels. The Journal of General Physiology. 120: 87-97. PMID 12084778 DOI: 10.1085/jgp.20028611  1
2002 Horn R. Molecular basis for function in sodium channels. Novartis Foundation Symposium. 241: 21-6; discussion 26-. PMID 11771648  1
2001 Ding S, Horn R. Slow photo-cross-linking kinetics of benzophenone-labeled voltage sensors of ion channels. Biochemistry. 40: 10707-16. PMID 11524017 DOI: 10.1021/bi010709y  1
2000 Horn R. Conversation between voltage sensors and gates of ion channels. Biochemistry. 39: 15653-8. PMID 11123889 DOI: 10.1021/bi0020473  1
2000 Horn R, Ding S, Gruber HJ. Immobilizing the moving parts of voltage-gated ion channels. The Journal of General Physiology. 116: 461-76. PMID 10962021 DOI: 10.1085/jgp.116.3.461  1
2000 Mitrovic N, George AL, Horn R. Role of domain 4 in sodium channel slow inactivation. The Journal of General Physiology. 115: 707-18. PMID 10828245 DOI: 10.1085/jgp.115.6.707  1
2000 Horn R. A new twist in the saga of charge movement in voltage-dependent ion channels. Neuron. 25: 511-4. PMID 10774720  1
1999 Horn R. The dual role of calcium: pore blocker and modulator of gating. Proceedings of the National Academy of Sciences of the United States of America. 96: 3331-2. PMID 10097036 DOI: 10.1073/pnas.96.7.3331  1
1999 Townsend C, Horn R. Interaction between the pore and a fast gate of the cardiac sodium channel. The Journal of General Physiology. 113: 321-32. PMID 9925827 DOI: 10.1085/jgp.113.2.321  1
1998 Horn R. Run, don't hop, through the nearest calcium channel. Biophysical Journal. 75: 1142-3. PMID 9726916  1
1998 Horn R. Explorations of voltage-dependent conformational changes using cysteine scanning. Methods in Enzymology. 293: 145-55. PMID 9711607 DOI: 10.1016/S0076-6879(98)93012-9  1
1998 Mitrovic N, George AL, Horn R. Independent versus coupled inactivation in sodium channels. Role of the domain 2 S4 segment. The Journal of General Physiology. 111: 451-62. PMID 9482711 DOI: 10.1085/jgp.111.3.451  1
1997 Yang N, George AL, Horn R. Probing the outer vestibule of a sodium channel voltage sensor. Biophysical Journal. 73: 2260-8. PMID 9370423 DOI: 10.1016/S0006-3495(97)78258-4  1
1997 Townsend C, Horn R. Effect of alkali metal cations on slow inactivation of cardiac Na+ channels. The Journal of General Physiology. 110: 23-33. PMID 9234168 DOI: 10.1085/jgp.110.1.23  1
1997 Townsend C, Hartmann HA, Horn R. Anomalous effect of permeant ion concentration on peak open probability of cardiac Na+ channels. The Journal of General Physiology. 110: 11-21. PMID 9234167 DOI: 10.1085/jgp.110.1.11  1
1996 Chen LQ, Santarelli V, Horn R, Kallen RG. A unique role for the S4 segment of domain 4 in the inactivation of sodium channels. The Journal of General Physiology. 108: 549-56. PMID 8972392 DOI: 10.1085/jgp.108.6.549  1
1996 Horn R. Counting charges. The Journal of General Physiology. 108: 129-32. PMID 8882858  1
1996 Tang L, Kallen RG, Horn R. Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker. The Journal of General Physiology. 108: 89-104. PMID 8854339  1
1996 Ji S, George AL, Horn R, Barchi RL. Paramyotonia congenita mutations reveal different roles for segments S3 and S4 of domain D4 in hSkM1 sodium channel gating. The Journal of General Physiology. 107: 183-94. PMID 8833340 DOI: 10.1085/jgp.107.2.183  1
1996 French RJ, Prusak-Sochaczewski E, Zamponi GW, Becker S, Kularatna AS, Horn R. Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry. Neuron. 16: 407-13. PMID 8789955 DOI: 10.1016/S0896-6273(00)80058-6  1
1996 Yang N, George AL, Horn R. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16: 113-22. PMID 8562074 DOI: 10.1016/S0896-6273(00)80028-8  1
1995 Chahine M, Chen LQ, Fotouhi N, Walsky R, Fry D, Santarelli V, Horn R, Kallen RG. Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations. Receptors & Channels. 3: 161-74. PMID 8821790  1
1995 O'Leary ME, Chen LQ, Kallen RG, Horn R. A molecular link between activation and inactivation of sodium channels. The Journal of General Physiology. 106: 641-58. PMID 8576701 DOI: 10.1085/jgp.106.4.641  1
1995 Ji S, George AL, Horn R, Barchi RL. Sodium channel mutations and disorders of excitation in human skeletal muscle. Society of General Physiologists Series. 50: 61-76. PMID 7676325  1
1995 Yang N, Horn R. Evidence for voltage-dependent S4 movement in sodium channels. Neuron. 15: 213-8. PMID 7619524 DOI: 10.1016/0896-6273(95)90078-0  1
1994 Chahine M, George AL, Zhou M, Ji S, Sun W, Barchi RL, Horn R. Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron. 12: 281-94. PMID 8110459 DOI: 10.1016/0896-6273(94)90271-2  1
1994 Chahine M, Bennett PB, George AL, Horn R. Functional expression and properties of the human skeletal muscle sodium channel. PflüGers Archiv : European Journal of Physiology. 427: 136-42. PMID 8058462 DOI: 10.1007/BF00585952  1
1994 Ji S, Sun W, George AL, Horn R, Barchi RL. Voltage-dependent regulation of modal gating in the rat SkM1 sodium channel expressed in Xenopus oocytes. The Journal of General Physiology. 104: 625-43. PMID 7836935 DOI: 10.1085/jgp.104.4.625  1
1994 Yang N, Ji S, Zhou M, Ptácek LJ, Barchi RL, Horn R, George AL. Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro. Proceedings of the National Academy of Sciences of the United States of America. 91: 12785-9. PMID 7809121 DOI: 10.1073/pnas.91.26.12785  1
1994 O'Leary ME, Kallen RG, Horn R. Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels. The Journal of General Physiology. 104: 523-39. PMID 7807060  1
1994 O'Leary ME, Horn R. Internal block of human heart sodium channels by symmetrical tetra-alkylammoniums. The Journal of General Physiology. 104: 507-22. PMID 7807059  1
1994 Liévano A, Bolden A, Horn R. Calcium channels in excitable cells: divergent genotypic and phenotypic expression of alpha 1-subunits. The American Journal of Physiology. 267: C411-24. PMID 7521126  1
1994 Lievano A, Bolden A, Horn R. Calcium channels in excitable cells: Divergent genotypic and phenotypic expression of alpha1-subunits Am.J.Physiol.. 267: C411-C424.  1
1993 Margolskee RF, McHendry-Rinde B, Horn R. Panning transfected cells for electrophysiological studies. Biotechniques. 15: 906-11. PMID 7505602  1
1992 Horn R, Korn SJ. Prevention of rundown in electrophysiological recording. Methods in Enzymology. 207: 149-55. PMID 1382181  1
1992 Chahine M, Chen LQ, Barchi RL, Kallen RG, Horn R. Lidocaine block of human heart sodium channels expressed in Xenopus oocytes. Journal of Molecular and Cellular Cardiology. 24: 1231-6. PMID 1336062 DOI: 10.1016/0022-2828(92)93090-7  1
1992 Chen LQ, Chahine M, Kallen RG, Barchi RL, Horn R. Chimeric study of sodium channels from rat skeletal and cardiac muscle. Febs Letters. 309: 253-7. PMID 1325372 DOI: 10.1016/0014-5793(92)80783-D  1
1992 Chahine M, Chen LQ, Kallen RG, Barchi RL, Horn R. Expressed Na channel clones differ in their sensitivity to external calcium concentration. Biophysical Journal. 62: 37-40. PMID 1318104 DOI: 10.1016/S0006-3495(92)81771-X  1
1992 Gellens ME, George AL, Chen LQ, Chahine M, Horn R, Barchi RL, Kallen RG. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 89: 554-8. PMID 1309946  1
1991 Horn R. Diffusion of nystatin in plasma membrane is inhibited by a glass-membrane seal Biophysical Journal. 60: 329-333. PMID 1912275  1
1991 Morris CE, Horn R. Failure to elicit neuronal macroscopic mechanosensitive currents anticipated by single-channel studies Science. 251: 1246-1249. PMID 1706535  1
1991 Korn SJ, Horn R. A [Na+]o-independent, pHo-dependent mechanism for reduction of intracellular [Ca2+] after influx through Ca2+ channels in mouse pituitary cells. The Journal of General Physiology. 98: 893-907. PMID 1662685  1
1991 Korn SJ, Bolden A, Horn R. Control of action potentials and Ca2+ influx by the Ca(2+)-dependent chloride current in mouse pituitary cells. The Journal of Physiology. 439: 423-37. PMID 1654415  1
1991 Morris CE, Horn R. Single-channel mechanosensitive currents [7] Science. 253: 801-802.  1
1991 Horn R. Estimating the number of channels in patch recordings Biophysical Journal. 60: 433-439.  1
1990 Fiorica-Howells E, Gambale F, Horn R, Osses L, Spector S. Phencyclidine blocks voltage-dependent potassium currents in murine thymocytes Journal of Pharmacology and Experimental Therapeutics. 252: 610-615. PMID 2313591  1
1990 Korn SJ, Horn R. Nordihydroguaiaretic acid inhibits voltage-activated Ca2+ currents independently of lipoxygenase inhibition. Molecular Pharmacology. 38: 524-30. PMID 2172768  1
1989 Horn R, Korn SJ. Model selection: reliability and bias. Biophysical Journal. 55: 379-81. PMID 2713450 DOI: 10.1016/S0006-3495(89)82816-4  1
1989 Marty A, Horn R, Tan YP, Zimmerberg J. Delay of the Ca mobilization response to muscarinic stimulation. Society of General Physiologists Series. 44: 97-110. PMID 2675326  1
1989 Korn SJ, Horn R. Influence of sodium-calcium exchange on calcium current rundown and the duration of calcium-dependent chloride currents in pituitary cells, studied with whole cell and perforated patch recording. The Journal of General Physiology. 94: 789-812. PMID 2556494  1
1988 Korn SJ, Horn R. Statistical discrimination of fractal and Markov models of single-channel gating. Biophysical Journal. 54: 871-7. PMID 2468367 DOI: 10.1016/S0006-3495(88)83023-6  1
1988 Horn R, Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. The Journal of General Physiology. 92: 145-59. PMID 2459299  1
1988 Augustine GJ, Charlton MP, Horn R. Role of calcium-activated potassium channels in transmitter release at the squid giant synapse. The Journal of Physiology. 398: 149-64. PMID 2455797  1
1987 Horn R. Statistical methods for model discrimination. Applications to gating kinetics and permeation of the acetylcholine receptor channel Biophysical Journal. 51: 255-263. PMID 2435330  1
1986 Weiss RE, Horn R. Single-channel studies of TTX-sensitive and TTX-resistant sodium channels in developing rat muscle reveal different open channel properties Annals of the New York Academy of Sciences. 152-161. PMID 2433988  1
1986 Weiss RE, Horn R. Functional differences between two classes of sodium channels in developing rat skeletal muscle Science. 233: 361-364. PMID 2425432  1
1986 Patlak JB, Ortiz M, Horn R. Opentime heterogeneity during bursting of sodium channels in frog skeletal muscle Biophysical Journal. 49: 773-777. PMID 2421796  1
1985 O'Lague PH, Huttner SL, Vandenberg CA, Morrison-Graham K, Horn R. Morphological properties and membrane channels of the growth cones induced in PC12 cells by nerve growth factor. Journal of Neuroscience Research. 13: 301-21. PMID 2579242 DOI: 10.1002/jnr.490130120  1
1984 Durant NN, Horn R. Org. 6368: A nondepolarizing neuromuscular blocking agent with a novel effect on end-plate conductance Journal of Pharmacology and Experimental Therapeutics. 228: 567-572. PMID 6608583  1
1984 Horn R, Vandenberg CA, Lange K. Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophysical Journal. 45: 323-35. PMID 6324912 DOI: 10.1016/S0006-3495(84)84158-2  1
1984 Vandenberg CA, Horn R. Inactivation viewed through single sodium channels. The Journal of General Physiology. 84: 535-64. PMID 6094704  1
1984 Horn R, Vandenberg CA. Statistical properties of single sodium channels. The Journal of General Physiology. 84: 505-34. PMID 6094703  1
1984 Horn R. Gating of Channels in Nerve and Muscie: A Stochastic Approach Current Topics in Membranes and Transport. 21: 53-97. DOI: 10.1016/S0070-2161(08)60435-9  1
1983 Horn R, Lange K. Estimating kinetic constants from single channel data Biophysical Journal. 43: 207-223. PMID 6311301  1
1983 French RJ, Horn R. SODIUM CHANNEL GATING: MODELS, MIMICS, AND MODIFIERS Annual Review of Biophysics and Bioengineering. 12: 319-356. PMID 6307117  1
1983 Eisenman G, Horn R. Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels The Journal of Membrane Biology. 76: 197-225. PMID 6100862 DOI: 10.1007/BF01870364  1
1982 Patlak J, Horn R. Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches Journal of General Physiology. 79: 333-351. PMID 6281357  1
1981 Horn R, Patlak J, Stevens CF. The effect of tetramethylammonium on single sodium channel currents. Biophysical Journal. 36: 321-7. PMID 6272896 DOI: 10.1016/S0006-3495(81)84734-0  1
1981 Horn R, Patlak J, Stevens CF. Sodium channels need not open before they inactivate. Nature. 291: 426-7. PMID 6264305 DOI: 10.1038/291426a0  1
1981 Horn R, Patlak J, Stevens C. Single sodium channel currents in excised membrane patches Biophysical Journal. 33: T-PM-D10.  1
1980 Horn R, Brodwick MS, Dickey WD. Asymmetry of the acetylcholine channel revealed by quaternary anesthetics Science. 210: 205-207. PMID 6251552  1
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