Peter K. Stys, M.D., FRCP (C) - Publications

Affiliations: 
Departments of Clinical Neurosciences University of Calgary, Calgary, Alberta, Canada 
Area:
Axon physiology, Ca imaging, Ca stores, Confocal and 2-photon microsc, Electrophysiology, Glutamate Receptors, Myelin, Na channels, Neuroprotection, White matter injury
Website:
http://www.ucalgary.ca/styslab/Projects

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 't Hart BA, Luchicchi A, Schenk GJ, Stys PK, Geurts JJG. Mechanistic underpinning of an inside-out concept for autoimmunity in multiple sclerosis. Annals of Clinical and Translational Neurology. PMID 34156169 DOI: 10.1002/acn3.51401  0.335
2021 Morgan ML, Brideau C, Teo W, Caprariello AV, Stys PK. Label-free assessment of myelin status using birefringence microscopy. Journal of Neuroscience Methods. 109226. PMID 34052286 DOI: 10.1016/j.jneumeth.2021.109226  0.738
2021 Teo W, Caprariello AV, Morgan ML, Luchicchi A, Schenk GJ, Joseph JT, Geurts JJG, Stys PK. Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33593907 DOI: 10.1073/pnas.2016897118  0.757
2021 Luchicchi A, Hart B', Frigerio I, van Dam AM, Perna L, Offerhaus HL, Stys PK, Schenk GJ, Geurts JJG. Axon-myelin unit blistering as early event in MS normal appearing white matter. Annals of Neurology. PMID 33410190 DOI: 10.1002/ana.26014  0.351
2020 Chu TH, Cummins K, Stys PK. Traumatic Injury Reduces Amyloid Plaque Burden in the Transgenic 5xFAD Alzheimer's Mouse Spinal Cord. Journal of Alzheimer's Disease : Jad. PMID 32925040 DOI: 10.3233/Jad-200387  0.368
2020 Morgan ML, Kaushik DK, Stys PK, Caprariello AV. Autofluorescence spectroscopy as a proxy for chronic white matter pathology. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458520948221. PMID 32779553 DOI: 10.1177/1352458520948221  0.736
2020 Plemel JR, Stratton JA, Michaels NJ, Rawji KS, Zhang E, Sinha S, Baaklini CS, Dong Y, Ho M, Thorburn K, Friedman TN, Jawad S, Silva C, Caprariello AV, Hoghooghi V, ... ... Stys PK, et al. Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. Science Advances. 6: eaay6324. PMID 31998844 DOI: 10.1126/Sciadv.Aay6324  0.772
2020 Grochmal J, Teo W, Gambhir H, Kumar R, Stratton JA, Dhaliwal R, Brideau C, Biernaskie J, Stys P, Midha R. Spectral Characterization of Stem Cell-Derived Myelination within the Injured Adult PNS Using the Solvatochromic Dye Nile Red. Cells. 9. PMID 31940829 DOI: 10.3390/cells9010189  0.352
2019 Stys PK, Tsutsui S. Recent advances in understanding multiple sclerosis. F1000research. 8. PMID 31885862 DOI: 10.12688/F1000Research.20906.1  0.37
2019 Brideau C, Poon KWC, Colarusso P, Stys PK. Excitation parameters optimized for coherent anti-Stokes Raman scattering imaging of myelinated tissue. Journal of Biomedical Optics. 24: 1-8. PMID 31007003 DOI: 10.1117/1.Jbo.24.4.046502  0.331
2018 Caprariello AV, Stys PK. Turned Inside Out: Will Myelin-Protective Therapies Become the Next-Generation Anti-Inflammatories? Dna and Cell Biology. PMID 30461299 DOI: 10.1089/Dna.2018.4496  0.764
2018 Caprariello AV, Rogers JA, Morgan ML, Hoghooghi V, Plemel JR, Koebel A, Tsutsui S, Dunn JF, Kotra LP, Ousman SS, Wee Yong V, Stys PK. Biochemically altered myelin triggers autoimmune demyelination. Proceedings of the National Academy of Sciences of the United States of America. PMID 29728463 DOI: 10.1073/Pnas.1721115115  0.805
2018 Poon KWC, Brideau C, Klaver R, Schenk GJ, Geurts JJ, Stys PK. Lipid biochemical changes detected in normal appearing white matter of chronic multiple sclerosis by spectral coherent Raman imaging. Chemical Science. 9: 1586-1595. PMID 29675203 DOI: 10.1039/C7Sc03992A  0.425
2018 Chu TH, Cummins K, Stys PK. The triple monoamine re-uptake inhibitor DOV 216,303 promotes functional recovery after spinal cord contusion injury in mice. Neuroscience Letters. PMID 29578004 DOI: 10.1016/J.Neulet.2018.03.050  0.333
2018 Caprariello AV, Stys PK. Two steps forward for myelin repair in multiple sclerosis. The Lancet. Neurology. PMID 29496303 DOI: 10.1016/S1474-4422(18)30070-X  0.758
2018 Rawji KS, Kappen J, Tang W, Teo W, Plemel JR, Stys PK, Yong VW. Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Ageing Mice Visualized by Ex Vivo Live Multiphoton Imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29363580 DOI: 10.1523/Jneurosci.2341-17.2018  0.76
2018 Grochmal J, Teo W, Gambhir H, Kumar R, Stratton JA, Dhaliwal R, Brideau C, Biernaskie J, Stys PK, Midha R. A novel approach to 32-channel peripheral nervous system myelin imaging in vivo, with single axon resolution. Journal of Neurosurgery. 1-9. PMID 29350602 DOI: 10.3171/2017.6.Jns17239  0.405
2017 Micu I, Plemel JR, Caprariello AV, Nave KA, Stys PK. Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system. Nature Reviews. Neuroscience. 19: 58. PMID 29238086 DOI: 10.1038/nrn.2017.166  0.778
2017 Chu TH, Cummins K, Sparling JS, Tsutsui S, Brideau C, Nilsson KPR, Joseph JT, Stys PK. Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord. Plos One. 12: e0188218. PMID 29176903 DOI: 10.1371/Journal.Pone.0188218  0.362
2017 Micu I, Plemel JR, Caprariello AV, Nave KA, Stys PK. Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system. Nature Reviews. Neuroscience. PMID 29118449 DOI: 10.1038/Nrn.2017.128  0.806
2017 Plemel JR, Michaels NJ, Weishaupt N, Caprariello AV, Keough MB, Rogers JA, Yukseloglu A, Lim J, Patel VV, Rawji KS, Jensen SK, Teo W, Heyne B, Whitehead SN, Stys PK, et al. Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy. Glia. PMID 29068088 DOI: 10.1002/Glia.23245  0.785
2017 Micu I, Brideau C, Lu L, Stys PK. Effects of laser polarization on responses of the fluorescent Ca(2+) indicator X-Rhod-1 in neurons and myelin. Neurophotonics. 4: 025002. PMID 28612034 DOI: 10.1117/1.Nph.4.2.025002  0.353
2017 Sarswat A, Wasilewski E, Chakka SK, Bello AM, Caprariello AV, Muthuramu CM, Stys PK, Dunn SE, Kotra LP. Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorganic & Medicinal Chemistry. PMID 28341402 DOI: 10.1016/J.Bmc.2017.03.006  0.715
2017 Plemel JR, Caprariello AV, Keough MB, Henry TJ, Tsutsui S, Chu TH, Schenk GJ, Klaver R, Yong VW, Stys PK. Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis. The Journal of Cell Biology. PMID 28264914 DOI: 10.1083/Jcb.201602028  0.752
2016 Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F. Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. The Lancet. Neurology. 15: 1089-1102. PMID 27571160 DOI: 10.1016/S1474-4422(16)30165-X  0.401
2016 Christensen PC, Samadi-Bahrami Z, Pavlov V, Stys PK, Wayne MG. Ionotropic glutamate receptor expression in human white matter. Neuroscience Letters. PMID 27443784 DOI: 10.1016/J.Neulet.2016.07.030  0.399
2016 Rawji KS, Mishra MK, Michaels NJ, Rivest S, Stys PK, Yong VW. Immunosenescence of microglia and macrophages: impact on the ageing central nervous system. Brain : a Journal of Neurology. 139: 653-61. PMID 26912633 DOI: 10.1093/Brain/Awv395  0.561
2016 Christensen PC, Welch NC, Brideau C, Stys PK. Functional ionotropic glutamate receptors on peripheral axons and myelin. Muscle & Nerve. PMID 26872412 DOI: 10.1002/mus.25078  0.322
2015 Micu I, Plemel JR, Lachance C, Proft J, Jansen AJ, Cummins K, van Minnen J, Stys PK. The molecular physiology of the axo-myelinic synapse. Experimental Neurology. PMID 26515690 DOI: 10.1016/J.Expneurol.2015.10.006  0.775
2015 Singh B, Krishnan A, Micu I, Koshy K, Singh V, Martinez JA, Koshy D, Xu F, Chandrasekhar A, Dalton C, Syed N, Stys PK, Zochodne DW. Peripheral neuron plasticity is enhanced by brief electrical stimulation and overrides attenuated regrowth in experimental diabetes. Neurobiology of Disease. PMID 26297317 DOI: 10.1016/J.Nbd.2015.08.009  0.309
2015 Shakhbazau A, Mishra M, Chu TH, Brideau C, Cummins K, Tsutsui S, Shcharbin D, Majoral JP, Mignani S, Blanchard-Desce M, Bryszewska M, Yong VW, Stys PK, van Minnen J. Fluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury. Macromolecular Bioscience. 15: 1523-34. PMID 26175127 DOI: 10.1002/Mabi.201500150  0.539
2015 Lampron A, Larochelle A, Laflamme N, Préfontaine P, Plante MM, Sánchez MG, Yong VW, Stys PK, Tremblay MÈ, Rivest S. Inefficient clearance of myelin debris by microglia impairs remyelinating processes. The Journal of Experimental Medicine. 212: 481-95. PMID 25779633 DOI: 10.1084/Jem.20141656  0.638
2015 Bellavance MA, Gosselin D, Yong VW, Stys PK, Rivest S. Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain Structure & Function. 220: 1759-76. PMID 24706067 DOI: 10.1007/S00429-014-0759-Z  0.541
2015 Poon KW, Brideau C, Schenk GJ, Klaver R, Klauser AM, Kawasoe JH, Geurts JJG, Stys PK. Quantitative biochemical investigation of various neuropathologies using high-resolution spectral CARS microscopy Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9305. DOI: 10.1117/12.2076654  0.444
2014 Okada SL, Stivers NS, Stys PK, Stirling DP. An ex vivo laser-induced spinal cord injury model to assess mechanisms of axonal degeneration in real-time. Journal of Visualized Experiments : Jove. e52173. PMID 25490396 DOI: 10.3791/52173  0.464
2014 Matute C, Stys PK. Editors' preface: the colourful white matter. Glia. 62: 1747-8. PMID 25212954 DOI: 10.1002/Glia.22747  0.335
2014 Fern RF, Matute C, Stys PK. White matter injury: Ischemic and nonischemic. Glia. 62: 1780-9. PMID 25043122 DOI: 10.1002/Glia.22722  0.477
2014 Plemel JR, Keough MB, Duncan GJ, Sparling JS, Yong VW, Stys PK, Tetzlaff W. Remyelination after spinal cord injury: is it a target for repair? Progress in Neurobiology. 117: 54-72. PMID 24582777 DOI: 10.1016/J.Pneurobio.2014.02.006  0.812
2014 Stirling DP, Cummins K, Wayne Chen SR, Stys P. Axoplasmic reticulum Ca2+ release causes secondary degeneration of spinal axons Annals of Neurology. 75: 220-229. PMID 24395428 DOI: 10.1002/Ana.24099  0.476
2014 Stirling DP, Cummins K, Mishra M, Teo W, Yong VW, Stys P. Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury. Brain : a Journal of Neurology. 137: 707-23. PMID 24369381 DOI: 10.1093/Brain/Awt341  0.624
2014 Grochmal J, Dhaliwal S, Stys PK, van Minnen J, Midha R. Skin-derived precursor Schwann cell myelination capacity in focal tibial demyelination. Muscle & Nerve. 50: 262-72. PMID 24282080 DOI: 10.1002/Mus.24136  0.463
2014 Christensen PC, Brideau C, Poon KW, Döring A, Yong VW, Stys PK. High-resolution fluorescence microscopy of myelin without exogenous probes. Neuroimage. 87: 42-54. PMID 24188810 DOI: 10.1016/J.Neuroimage.2013.10.050  0.603
2013 Koch MW, Cutter G, Stys PK, Yong VW, Metz LM. Treatment trials in progressive MS--current challenges and future directions. Nature Reviews. Neurology. 9: 496-503. PMID 23897406 DOI: 10.1038/Nrneurol.2013.148  0.49
2013 Stys PK. Pathoetiology of multiple sclerosis: are we barking up the wrong tree? F1000prime Reports. 5: 20. PMID 23755367 DOI: 10.12703/P5-20  0.348
2013 Tsutsui S, Stys PK. Metabolic injury to axons and myelin. Experimental Neurology. 246: 26-34. PMID 22569104 DOI: 10.1016/J.Expneurol.2012.04.016  0.465
2013 Poon KW, Brideau C, Teo W, Schenk GJ, Klaver R, Klauser AM, Kawasoe JH, Geurts JJG, Stys PK. Investigation of human multiple sclerosis lesions using high resolution spectrally unmixed CARS microscopy Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8565. DOI: 10.1117/12.2005504  0.443
2012 Stys PK, Zamponi GW, van Minnen J, Geurts JJ. Will the real multiple sclerosis please stand up? Nature Reviews. Neuroscience. 13: 507-14. PMID 22714021 DOI: 10.1038/Nrn3275  0.318
2012 Micu I, Brideau C, Stys PK. Polarization-dependent responses of fluorescent indicators partitioned into myelinated axons Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8207. DOI: 10.1117/12.908976  0.426
2011 Stys PK. The axo-myelinic synapse. Trends in Neurosciences. 34: 393-400. PMID 21741098 DOI: 10.1016/J.Tins.2011.06.004  0.459
2011 Murugkar S, Smith B, Naji M, Brideau C, Stys P, Anis H. Development of a micromirror-scanned multimodal CARS miniaturized microscope for the in vivo study of spinal cord disorders Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7903. DOI: 10.1117/12.875619  0.309
2010 Stys PK. Multiple sclerosis: autoimmune disease or autoimmune reaction? The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 37: S16-23. PMID 21246931 DOI: 10.1017/S0317167100022393  0.344
2010 Piña-Crespo JC, Talantova M, Micu I, States B, Chen HS, Tu S, Nakanishi N, Tong G, Zhang D, Heinemann SF, Zamponi GW, Stys PK, Lipton SA. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11501-5. PMID 20739572 DOI: 10.1523/Jneurosci.1593-10.2010  0.307
2010 Stirling DP, Stys PK. Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation. Trends in Molecular Medicine. 16: 160-70. PMID 20207196 DOI: 10.1016/J.Molmed.2010.02.002  0.469
2009 Tsutsui S, Stys PK. Degeneration versus autoimmunity in multiple sclerosis. Annals of Neurology. 66: 711-3. PMID 20033985 DOI: 10.1002/Ana.21845  0.348
2009 Geurts JJ, Stys PK, Minagar A, Amor S, Zivadinov R. Gray matter pathology in (chronic) MS: modern views on an early observation. Journal of the Neurological Sciences. 282: 12-20. PMID 19249061 DOI: 10.1016/J.Jns.2009.01.018  0.323
2009 Trapp BD, Stys PK. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. The Lancet. Neurology. 8: 280-91. PMID 19233038 DOI: 10.1016/S1474-4422(09)70043-2  0.472
2009 Ouardouz M, Coderre E, Basak A, Chen A, Zamponi GW, Hameed S, Rehak R, Yin X, Trapp BD, Stys PK. Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors. Annals of Neurology. 65: 151-9. PMID 19224535 DOI: 10.1002/Ana.21533  0.446
2009 Ouardouz M, Coderre E, Zamponi GW, Hameed S, Yin X, Trapp BD, Stys PK. Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Annals of Neurology. 65: 160-6. PMID 19224531 DOI: 10.1002/Ana.21539  0.429
2009 Nikolaeva MA, Richard S, Mouihate A, Stys PK. Effects of the noradrenergic system in rat white matter exposed to oxygen-glucose deprivation in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1796-804. PMID 19211886 DOI: 10.1523/Jneurosci.5729-08.2009  0.442
2009 Stys PK, Ransom BR, Black JA, Waxman SG. Anoxic/ischemic injury in axons The Axon: Structure, Function and Pathophysiology. DOI: 10.1093/acprof:oso/9780195082937.003.0024  0.656
2009 Stys PK, Waxman SG, Ransom BR. Ion pumps and exchangers The Axon: Structure, Function and Pathophysiology. DOI: 10.1093/acprof:oso/9780195082937.003.0015  0.516
2009 Waxman SG, Kocsis JD, Stys PK. The Axon: Structure, Function and Pathophysiology The Axon: Structure, Function and Pathophysiology. 1-708. DOI: 10.1093/acprof:oso/9780195082937.001.0001  0.433
2007 Stys PK, Lipton SA. White matter NMDA receptors: an unexpected new therapeutic target? Trends in Pharmacological Sciences. 28: 561-6. PMID 17961731 DOI: 10.1016/J.Tips.2007.10.003  0.436
2007 Micu I, Ridsdale A, Zhang L, Woulfe J, McClintock J, Brantner CA, Andrews SB, Stys PK. Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy. Nature Medicine. 13: 874-9. PMID 17603496 DOI: 10.1038/Nm1568  0.479
2007 Petrescu N, Micu I, Malek S, Ouardouz M, Stys PK. Sources of axonal calcium loading during in vitro ischemia of rat dorsal roots. Muscle & Nerve. 35: 451-7. PMID 17206661 DOI: 10.1002/Mus.20731  0.432
2006 Ouardouz M, Malek S, Coderre E, Stys PK. Complex interplay between glutamate receptors and intracellular Ca2+ stores during ischaemia in rat spinal cord white matter. The Journal of Physiology. 577: 191-204. PMID 16945971 DOI: 10.1113/Jphysiol.2006.116798  0.362
2006 Micu I, Jiang Q, Coderre E, Ridsdale A, Zhang L, Woulfe J, Yin X, Trapp BD, McRory JE, Rehak R, Zamponi GW, Wang W, Stys PK. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature. 439: 988-92. PMID 16372019 DOI: 10.1038/Nature04474  0.481
2006 Jette N, Coderre E, Nikolaeva MA, Enright PD, Iwata A, Smith DH, Jiang Q, Stys PK. Spatiotemporal distribution of spectrin breakdown products induced by anoxia in adult rat optic nerve in vitro. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 777-86. PMID 16163297 DOI: 10.1038/Sj.Jcbfm.9600226  0.455
2005 Nikolaeva MA, Mukherjee B, Stys PK. Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9960-7. PMID 16251444 DOI: 10.1523/Jneurosci.2003-05.2005  0.397
2005 Stys PK. General mechanisms of axonal damage and its prevention. Journal of the Neurological Sciences. 233: 3-13. PMID 15899499 DOI: 10.1016/J.Jns.2005.03.031  0.439
2005 Malek SA, Adorante JS, Stys PK. Differential effects of Na-K-ATPase pump inhibition, chemical anoxia, and glycolytic blockade on membrane potential of rat optic nerve. Brain Research. 1037: 171-9. PMID 15777766 DOI: 10.1016/J.Brainres.2005.01.003  0.334
2005 Ouardouz M, Zamponi GW, Barr W, Kiedrowski L, Stys PK. Protection of ischemic rat spinal cord white matter: Dual action of KB-R7943 on Na+/Ca2+ exchange and L-type Ca2+ channels. Neuropharmacology. 48: 566-75. PMID 15755484 DOI: 10.1016/J.Neuropharm.2004.12.007  0.321
2005 Stys PK, Waxman SG. Molecular Mechanisms of Calcium Influx in Axonal Degeneration Multiple Sclerosis as a Neuronal Disease. 275-292. DOI: 10.1016/B978-012738761-1/50020-1  0.417
2004 Iwata A, Stys PK, Wolf JA, Chen XH, Taylor AG, Meaney DF, Smith DH. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4605-13. PMID 15140932 DOI: 10.1523/Jneurosci.0515-03.2004  0.441
2004 Stys PK. Axonal degeneration in multiple sclerosis: is it time for neuroprotective strategies? Annals of Neurology. 55: 601-3. PMID 15122698 DOI: 10.1002/Ana.20082  0.418
2004 Stys PK. White matter injury mechanisms. Current Molecular Medicine. 4: 113-30. PMID 15032708 DOI: 10.2174/1566524043479220  0.49
2004 Zhang CL, Verbny Y, Malek SA, Stys PK, Chiu SY. Nicotinic acetylcholine receptors in mouse and rat optic nerves. Journal of Neurophysiology. 91: 1025-35. PMID 14762152 DOI: 10.1152/Jn.00769.2003  0.369
2004 Stys PK. Molecular mechanisms of CNS axonal injury: Lessons from anoxia/ischemia Advanced Studies in Medicine. 4: S327-S330.  0.328
2003 Ouardouz M, Nikolaeva MA, Coderre E, Zamponi GW, McRory JE, Trapp BD, Yin X, Wang W, Woulfe J, Stys PK. Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron. 40: 53-63. PMID 14527433 DOI: 10.1016/J.Neuron.2003.08.016  0.345
2003 Brinkmeier H, Weber F, Aulkemeyer P, Wollinsky KH, Rüdel R, Cummins TR, Renganathan M, Herzog RI, Dib-Hajj SD, Waxman SG, Stys PK, Horn R. The pentapeptide QYNAD does not block voltage-gated sodium channels [4] (multiple letters) Neurology. 60: 1871-1872. PMID 12796562  0.467
2003 Malek SA, Coderre E, Stys PK. Aberrant chloride transport contributes to anoxic/ischemic white matter injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3826-36. PMID 12736353 DOI: 10.1523/Jneurosci.23-09-03826.2003  0.456
2003 Cummins TR, Renganathan M, Stys PK, Herzog RI, Scarfo K, Horn R, Dib-Hajj SD, Waxman SG. The pentapeptide QYNAD does not block voltage-gated sodium channels. Neurology. 60: 224-9. PMID 12552035 DOI: 10.1212/01.Wnl.0000042423.36650.Bd  0.633
2003 Stys PK, Waxman SG. Ischemic White Matter Damage Myelin Biology and Disorders. 2: 985-1007. DOI: 10.1016/B978-012439510-7/50094-2  0.407
2002 Stys PK, Jiang Q. Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons. Neuroscience Letters. 328: 150-4. PMID 12133577 DOI: 10.1016/S0304-3940(02)00469-X  0.404
2001 Hewitt KE, Stys PK, Lesiuk HJ. The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury. Brain Research. 898: 281-7. PMID 11306014 DOI: 10.1016/S0006-8993(01)02195-3  0.398
2001 Wolf JA, Stys PK, Lusardi T, Meaney D, Smith DH. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1923-30. PMID 11245677 DOI: 10.1523/Jneurosci.21-06-01923.2001  0.385
2000 Ren Y, Ridsdale A, Coderre E, Stys PK. Calcium imaging in live rat optic nerve myelinated axons in vitro using confocal laser microscopy. Journal of Neuroscience Methods. 102: 165-76. PMID 11040413 DOI: 10.1016/S0165-0270(00)00304-6  0.429
2000 Li S, Jiang Q, Stys PK. Important role of reverse Na(+)-Ca(2+) exchange in spinal cord white matter injury at physiological temperature. Journal of Neurophysiology. 84: 1116-9. PMID 10938336 DOI: 10.1152/Jn.2000.84.2.1116  0.655
2000 Jiang Q, Stys PK. Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves. Journal of Neurochemistry. 74: 2101-7. PMID 10800955 DOI: 10.1046/J.1471-4159.2000.0742101.X  0.419
2000 Li S, Stys PK. Mechanisms of Ionotropic Glutamate Receptor-Mediated Excitotoxicity in Isolated Spinal Cord White Matter The Journal of Neuroscience. 20: 1190-1198. DOI: 10.1523/Jneurosci.20-03-01190.2000  0.651
2000 Stys PK, Li S. Glutamate-Induced White Matter Injury: Excitotoxicity without Synapses The Neuroscientist. 6: 230-233. DOI: 10.1177/107385840000600405  0.682
1999 Li S, Mealing GAR, Morley P, Stys PK. Novel Injury Mechanism in Anoxia and Trauma of Spinal Cord White Matter: Glutamate Release via Reverse Na+-dependent Glutamate Transport The Journal of Neuroscience. 19. DOI: 10.1523/Jneurosci.19-14-J0002.1999  0.638
1998 Stys PK, Hubatsch DA, Leppanen LL. Effects of K+ channel blockers on the anoxic response of CNS myelinated axons. Neuroreport. 9: 447-53. PMID 9512388 DOI: 10.1097/00001756-199802160-00017  0.398
1998 Stys PK. Anoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 2-25. PMID 9428302 DOI: 10.1097/00004647-199801000-00002  0.516
1997 Steffensen I, Waxman SG, Mills L, Stys PK. Immunolocalization of the Na(+)-Ca2+ exchanger in mammalian myelinated axons. Brain Research. 776: 1-9. PMID 9439790 DOI: 10.1016/S0006-8993(97)00868-8  0.593
1997 Leppanen L, Stys PK. Ion transport and membrane potential in CNS myelinated axons. II. Effects of metabolic inhibition. Journal of Neurophysiology. 78: 2095-107. PMID 9325377 DOI: 10.1152/Jn.1997.78.4.2095  0.401
1997 Leppanen L, Stys PK. Ion transport and membrane potential in CNS myelinated axons I. Normoxic conditions. Journal of Neurophysiology. 78: 2086-94. PMID 9325376 DOI: 10.1152/Jn.1997.78.4.2086  0.394
1997 Stys PK, Lehning E, Saubermann AJ, LoPachin RM. Intracellular concentrations of major ions in rat myelinated axons and glia: calculations based on electron probe X-ray microanalyses. Journal of Neurochemistry. 68: 1920-8. PMID 9109518 DOI: 10.1046/J.1471-4159.1997.68051920.X  0.409
1996 Stys PK, Lesiuk H. Correlation between electrophysiological effects of mexiletine and ischemic protection in central nervous system white matter. Neuroscience. 71: 27-36. PMID 8834390 DOI: 10.1016/0306-4522(95)00430-0  0.354
1996 Stys PK, Lopachin RM. Elemental composition and water content of rat optic nerve myelinated axons during in vitro post-anoxia reoxygenation. Neuroscience. 73: 1081-90. PMID 8809826 DOI: 10.1016/0306-4522(96)00114-5  0.477
1996 Lehning EJ, Stys PK, LoPachin RM. Reoxygenation of anoxic peripheral nerve myelinated axons promotes re-establishment of normal elemental composition. Brain Research. 715: 189-96. PMID 8739638 DOI: 10.1016/0006-8993(95)01582-5  0.441
1996 Stys PK, Steffensen I. Na(+)-Ca2+ exchange in anoxic/ischemic injury of CNS myelinated axons. Annals of the New York Academy of Sciences. 779: 366-78. PMID 8659849 DOI: 10.1111/J.1749-6632.1996.Tb44808.X  0.495
1996 Lehning EJ, Doshi R, Isaksson N, Stys PK, LoPachin RM. Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: role of reverse sodium-calcium exchange. Journal of Neurochemistry. 66: 493-500. PMID 8592118 DOI: 10.1046/J.1471-4159.1996.66020493.X  0.424
1996 Steffensen I, Stys PK. REVIEW ■ : The Na-Ca Exchanger in Neurons and Glial Cells The Neuroscientist. 2: 162-171. DOI: 10.1177/107385849600200311  0.349
1995 Lehning EJ, Doshi R, Stys PK, LoPachin RM. Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: in vitro anoxia and ouabain exposure. Brain Research. 694: 158-66. PMID 8974640 DOI: 10.1016/0006-8993(95)00855-K  0.464
1995 Stys PK. Protective effects of antiarrhythmic agents against anoxic injury in CNS white matter. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 425-32. PMID 7714000 DOI: 10.1038/Jcbfm.1995.53  0.438
1995 LoPachin RM, Stys PK. Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 6735-46. PMID 7472432  0.332
1994 Waxman SG, Black JA, Ransom BR, Stys PK. Anoxic injury of rat optic nerve: ultrastructural evidence for coupling between Na+ influx and Ca(2+)-mediated injury in myelinated CNS axons. Brain Research. 644: 197-204. PMID 8050031 DOI: 10.1016/0006-8993(94)91680-2  0.705
1994 Stys PK, Waxman SG. Activity-dependent modulation of excitability: implications for axonal physiology and pathophysiology. Muscle & Nerve. 17: 969-74. PMID 7520532 DOI: 10.1002/Mus.880170902  0.513
1993 Ransom BR, Waxman SG, Stys PK. Anoxic injury of central myelinated axons: ionic mechanisms and pharmacology. Research Publications - Association For Research in Nervous and Mental Disease. 71: 121-51. PMID 8417464  0.693
1993 Stys PK, Sontheimer H, Ransom BR, Waxman SG. Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons. Proceedings of the National Academy of Sciences of the United States of America. 90: 6976-80. PMID 8394004 DOI: 10.1073/Pnas.90.15.6976  0.68
1993 Fern R, Ransom BR, Stys PK, Waxman SG. Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam. The Journal of Pharmacology and Experimental Therapeutics. 266: 1549-55. PMID 8371157  0.624
1993 Waxman SG, Black JA, Ransom BR, Stys PK. Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium. Brain Research. 614: 137-45. PMID 8348309 DOI: 10.1016/0006-8993(93)91027-P  0.688
1992 Waxman SG, Black JA, Stys PK, Ransom BR. Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve. Brain Research. 574: 105-19. PMID 1638387 DOI: 10.1016/0006-8993(92)90806-K  0.686
1992 Stys PK, Waxman SG, Ransom BR. Effects of temperature on evoked electrical activity and anoxic injury in CNS white matter. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 12: 977-86. PMID 1400652 DOI: 10.1038/Jcbfm.1992.135  0.658
1992 Stys PK, Ransom BR, Waxman SG. Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability. Journal of Neurophysiology. 67: 236-40. PMID 1313081 DOI: 10.1152/Jn.1992.67.1.236  0.691
1992 Stys PK, Waxman SG, Ransom BR. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 430-9. PMID 1311030 DOI: 10.1523/Jneurosci.12-02-00430.1992  0.692
1991 Stys PK, Waxman SG, Ransom BR. Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Annals of Neurology. 30: 375-80. PMID 1952825 DOI: 10.1002/Ana.410300309  0.668
1991 Stys PK, Ransom BR, Waxman SG. Compound action potential of nerve recorded by suction electrode: a theoretical and experimental analysis. Brain Research. 546: 18-32. PMID 1855148 DOI: 10.1016/0006-8993(91)91154-S  0.591
1991 Stys PK, Waxman SG, Ransom BR. Reverse operation of the Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian CNS white matter. Annals of the New York Academy of Sciences. 639: 328-32. PMID 1785859 DOI: 10.1111/J.1749-6632.1991.Tb17321.X  0.612
1991 Waxman SG, Ransom BR, Stys PK. Non-synaptic mechanisms of Ca(2+)-mediated injury in CNS white matter. Trends in Neurosciences. 14: 461-8. PMID 1722366 DOI: 10.1016/0166-2236(91)90046-W  0.7
1991 Ransom B, Waxman S, Stys P. The pathophysiology of anoxic injury in mammalian central white matter Journal of the Neurological Sciences. 106: 118. DOI: 10.1016/0022-510X(91)90237-2  0.538
1990 Stys PK, Ransom BR, Waxman SG, Davis PK. Role of extracellular calcium in anoxic injury of mammalian central white matter. Proceedings of the National Academy of Sciences of the United States of America. 87: 4212-6. PMID 2349231 DOI: 10.1073/Pnas.87.11.4212  0.679
1990 Ransom BR, Stys PK, Waxman SG. The pathophysiology of anoxic injury in central nervous system white matter. Stroke; a Journal of Cerebral Circulation. 21: III52-7. PMID 2237986  0.642
1990 Stys PK, Ransom BR, Waxman SG. Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia. Neuroscience Letters. 115: 293-9. PMID 2234507 DOI: 10.1016/0304-3940(90)90471-K  0.655
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