Mark Rowland Hutchinson - Publications

Affiliations: 
Discipline of Physiology University of Adelaide, Adelaide, South Australia, Australia 
Area:
Neuroimmunopharmacology, Neuroscience, Immunology, Pharmacology

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liddicoat C, Sydnor H, Cando-Dumancela C, Dresken R, Liu J, Gellie NJC, Mills JG, Young JM, Weyrich LS, Hutchinson MR, Weinstein P, Breed MF. Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice. The Science of the Total Environment. 701: 134684. PMID 31704402 DOI: 10.1016/j.scitotenv.2019.134684  0.32
2019 Liu G, Bursill C, Cartland SP, Anwer AG, Parker LM, Zhang K, Feng S, He M, Inglis DW, Kavurma MM, Hutchinson MR, Goldys EM. A Nanoparticle-Based Affinity Sensor that Identifies and Selects Highly Cytokine-Secreting Cells. Iscience. 20: 137-147. PMID 31569048 DOI: 10.1016/j.isci.2019.09.019  0.32
2019 Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity. PMID 31542403 DOI: 10.1016/j.bbi.2019.09.013  1
2019 Chin PY, Dorian C, Sharkey DJ, Hutchinson MR, Rice KC, Moldenhauer LM, Robertson SA. Toll-like receptor-4 antagonist (+)-naloxone confers sexually dimorphic protection from inflammation-induced fetal programming in mice. Endocrinology. PMID 31504393 DOI: 10.1210/en.2019-00493  0.96
2019 Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier S, Bachtell RK, Hutchinson MR, Watkins LR. Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. Acs Chemical Neuroscience. PMID 31282647 DOI: 10.1021/acschemneuro.9b00225  1
2019 Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900173RRR. PMID 31162938 DOI: 10.1096/fj.201900173RRR  1
2019 Parker LM, Sayyadi N, Staikopoulos V, Shrestha A, Hutchinson MR, Packer NH. Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization. Journal of Neuroinflammation. 16: 65. PMID 30898121 DOI: 10.1186/s12974-019-1451-2  0.44
2018 Cao C, Jin R, Wei H, Yang WC, Goldys EM, Hutchinson MR, Liu S, Chen X, Yang GF, Liu G. Graphene Oxide Based Recyclable In vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice. Acs Applied Materials & Interfaces. PMID 30199621 DOI: 10.1021/acsami.8b13518  0.32
2018 Iacopetta K, Collins-Praino LE, Buisman-Pijlman FTA, Liu J, Hutchinson AD, Hutchinson MR. Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review. Nutritional Neuroscience. 1-30. PMID 29985117 DOI: 10.1080/1028415X.2018.1493807  0.32
2018 Bajic JE, Johnston IN, Howarth GS, Hutchinson MR. From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation. Frontiers in Behavioral Neuroscience. 12: 104. PMID 29872383 DOI: 10.3389/fnbeh.2018.00104  0.76
2018 Dodds KN, Beckett EAH, Evans SF, Hutchinson MR. Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain. Reproductive Sciences (Thousand Oaks, Calif.). 1933719118773405. PMID 29730970 DOI: 10.1177/1933719118773405  0.4
2018 Zhang K, Baratta MV, Liu G, Frank MG, Leslie NR, Watkins LR, Maier SF, Hutchinson MR, Goldys EM. A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain, Behavior, and Immunity. PMID 29678795 DOI: 10.1016/j.bbi.2018.04.011  1
2018 Beckett EAH, Staikopoulos V, Hutchinson MR. Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice. Scientific Reports. 8: 5923. PMID 29651005 DOI: 10.1038/s41598-018-23717-4  0.44
2018 Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X. Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. Journal of Chemical Information and Modeling. PMID 29518316 DOI: 10.1021/acs.jcim.7b00717  1
2018 Liu J, Mustafa S, Barratt DT, Hutchinson MR. Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells. Frontiers in Immunology. 9: 3. PMID 29403490 DOI: 10.3389/fimmu.2018.00003  0.68
2018 Robertson SA, Wahid HH, Chin PY, Hutchinson MR, Moldenhauer LM, Keelan JA. Toll-like receptor-4: A new target for preterm labour pharmacotherapies? Current Pharmaceutical Design. PMID 29384054 DOI: 10.2174/1381612824666180130122450  0.72
2017 Dodds KN, Beckett EAH, Evans SF, Hutchinson MR. Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally-invasive model of endometriosis. Biology of Reproduction. PMID 29069288 DOI: 10.1093/biolre/iox132  0.4
2017 Jacobsen JH, Buisman-Pijlman F, Mustafa S, Rice KC, Hutchinson MR. Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology. PMID 28947376 DOI: 10.1016/j.neuropharm.2017.09.028  0.96
2017 Jacobsen JHW, Buisman-Pijlman FT, Mustafa S, Rice KC, Hutchinson MR. The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity. PMID 28864261 DOI: 10.1016/j.bbi.2017.08.021  0.96
2017 Johnston IN, Tan M, Cao J, Matsos A, Forrest DRL, Si E, Fardell JE, Hutchinson MR. Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats. Behavioural Brain Research. PMID 28739131 DOI: 10.1016/j.bbr.2017.07.021  0.76
2017 Liu G, Zhang K, Nadort A, Hutchinson MR, Goldys EM. Sensitive Cytokine Assay Based on Optical Fiber Allowing Localized and Spatially Resolved Detection of Interleukin-6. Acs Sensors. 2: 218-226. PMID 28723139 DOI: 10.1021/acssensors.6b00619  0.32
2017 Liu G, Zhang K, Ma K, Care A, Hutchinson MR, Goldys EM. Graphene quantum dot based "switch-on" nanosensors for intracellular cytokine monitoring. Nanoscale. PMID 28368062 DOI: 10.1039/c6nr09381g  0.32
2016 Lewis SS, Grace PM, Hutchinson MR, Maier SF, Watkins LR. Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain, Behavior, and Immunity. PMID 27993689 DOI: 10.1016/j.bbi.2016.12.004  1
2016 Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends in Neurosciences. PMID 27842920 DOI: 10.1016/j.tins.2016.10.003  1
2016 Chin PY, Dorian CL, Hutchinson MR, Olson DM, Rice KC, Moldenhauer LM, Robertson SA. Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports. 6: 36112. PMID 27819333 DOI: 10.1038/srep36112  0.96
2016 Somogyi AA, Sia AT, Tan EC, Coller JK, Hutchinson MR, Barratt DT. Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Pain. PMID 27649267 DOI: 10.1097/j.pain.0000000000000661  1
2016 Dodds KN, Beckett EA, Evans SF, Grace PM, Watkins LR, Hutchinson MR. Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain. Translational Psychiatry. 6: e888. PMID 27622932 DOI: 10.1038/tp.2016.168  1
2016 Ellis A, Grace PM, Wieseler J, Favret J, Springer K, Skarda B, Hutchinson MR, Falci S, Rice KC, Maier SF, Watkins LR. Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity. PMID 27519154 DOI: 10.1016/j.bbi.2016.08.004  1
2016 Wardill HR, Gibson RJ, Van Sebille YZ, Secombe KR, Coller JK, White IA, Manavis J, Hutchinson MR, Staikopoulos V, Logan RM, Bowen JM. Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics. PMID 27197307 DOI: 10.1158/1535-7163.MCT-15-0990  1
2016 Jacobsen JH, Parker LM, Everest-Dass AV, Schartner EP, Tsiminis G, Staikopoulos V, Hutchinson MR, Mustafa S. Novel imaging tools for investigating the role of immune signalling in the brain. Brain, Behavior, and Immunity. PMID 27129634 DOI: 10.1016/j.bbi.2016.04.014  0.44
2016 Liu G, Qi M, Hutchinson MR, Yang G, Goldys EM. Recent advances in cytokine detection by immunosensing. Biosensors & Bioelectronics. 79: 810-821. PMID 26774995 DOI: 10.1016/j.bios.2016.01.020  0.32
2015 Jacobsen JH, Hutchinson MR, Mustafa S. Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy. Current Opinion in Pharmacology. 26: 131-137. PMID 26657076 DOI: 10.1016/j.coph.2015.10.010  0.44
2015 Wang X, Zhang Y, Peng Y, Hutchinson MR, Rice KC, Yin H, Watkins LR. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. British Journal of Pharmacology. PMID 26603732 DOI: 10.1111/bph.13394  1
2015 Gibson RJ, Coller JK, Wardill HR, Hutchinson MR, Smid S, Bowen JM. Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. PMID 26581898 DOI: 10.1007/s00520-015-3020-2  0.64
2015 Johnson JL, Kwok YH, Sumracki NM, Swift JE, Hutchinson MR, Johnson K, Williams DB, Tuke J, Rolan PE. Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety. Headache. PMID 26367865 DOI: 10.1111/head.12655  1
2015 Wahid HH, Dorian C, Yin Chin P, Hutchinson MR, Rice KC, Olson DM, Moldenhauer LM, Robertson SA. Toll-like receptor 4 is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology. EN20151089. PMID 26151355 DOI: 10.1210/EN.2015-1089  1
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. Cns & Neurological Disorders Drug Targets. 14: 692-9. PMID 26022268  1
2015 Ingman WV, Glynn DJ, Hutchinson MR. Mouse models of mastitis - how physiological are they? International Breastfeeding Journal. 10: 12. PMID 25848399 DOI: 10.1186/s13006-015-0038-5  1
2015 Li Y, Jackson KA, Slon B, Hardy JR, Franco M, William L, Poon P, Coller JK, Hutchinson MR, Currow DC, Somogyi AA. CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects. British Journal of Clinical Pharmacology. PMID 25702819 DOI: 10.1111/bcp.12614  1
2015 Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, et al. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry. PMID 25644383 DOI: 10.1038/mp.2014.177  1
2015 Corrigan F, Wu Y, Tuke J, Coller JK, Rice KC, Diener KR, Hayball JD, Watkins LR, Somogyi AA, Hutchinson MR. Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity. 45: 245-52. PMID 25542736 DOI: 10.1016/j.bbi.2014.12.019  1
2015 Lewis SS, Hutchinson MR, Frick MM, Zhang Y, Maier SF, Sammakia T, Rice KC, Watkins LR. Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 44: 128-36. PMID 25218902 DOI: 10.1016/j.bbi.2014.09.004  1
2015 Lee SM, Hutchinson M, Staikopoulos V, Saint DA. Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury International Journal of Cardiology. 190: 353-359. DOI: 10.1016/j.ijcard.2015.04.120  1
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the toll of drug abuse: The translational potential of toll-like receptor 4 Cns and Neurological Disorders - Drug Targets. 14: 692-698.  1
2014 Johnson JL, Rolan PE, Johnson ME, Bobrovskaya L, Williams DB, Johnson K, Tuke J, Hutchinson MR. Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry. 4: e482. PMID 25386959 DOI: 10.1038/tp.2014.121  1
2014 Liu J, Buisman-Pijlman F, Hutchinson MR. Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder. Frontiers in Neuroscience. 8: 309. PMID 25324715 DOI: 10.3389/fnins.2014.00309  1
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/j.neuroscience.2014.09.020  1
2014 Jacobsen JH, Watkins LR, Hutchinson MR. Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. International Review of Neurobiology. 118: 129-63. PMID 25175864 DOI: 10.1016/B978-0-12-801284-0.00006-3  1
2014 Watkins LR, Wang X, Mustafa S, Hutchinson MR. In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences. 35: 432-3. PMID 25109571 DOI: 10.1016/j.tips.2014.07.002  1
2014 Zwicker JD, Zhang Y, Ren J, Hutchinson MR, Rice KC, Watkins LR, Greer JJ, Funk GD. Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 857-68. PMID 25103966 DOI: 10.1152/japplphysiol.00534.2014  1
2014 Hutchinson MR. Want more pain? Just add a dash of endotoxin to enhance your clinical pain model. Brain, Behavior, and Immunity. 41: 44-5. PMID 24972264 DOI: 10.1016/j.bbi.2014.06.008  1
2014 Ingman WV, Glynn DJ, Hutchinson MR. Inflammatory mediators in mastitis and lactation insufficiency. Journal of Mammary Gland Biology and Neoplasia. 19: 161-7. PMID 24961655 DOI: 10.1007/s10911-014-9325-9  1
2014 Glynn DJ, Hutchinson MR, Ingman WV. Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of Reproduction. 90: 91. PMID 24671877 DOI: 10.1095/biolreprod.114.117663  1
2014 Watkins LR, Hutchinson MR. A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow. Trends in Neurosciences. 37: 189-90. PMID 24612510 DOI: 10.1016/j.tins.2014.02.004  1
2014 Nicotra L, Tuke J, Grace PM, Rolan PE, Hutchinson MR. Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed? Frontiers in Behavioral Neuroscience. 8: 40. PMID 24592221 DOI: 10.3389/fnbeh.2014.00040  1
2014 Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nature Reviews. Immunology. 14: 217-31. PMID 24577438 DOI: 10.1038/nri3621  1
2014 Sumracki NM, Buisman-Pijlman FT, Hutchinson MR, Gentgall M, Rolan P. Reduced response to the thermal grill illusion in chronic pain patients. Pain Medicine (Malden, Mass.). 15: 647-60. PMID 24517126 DOI: 10.1111/pme.12379  1
2014 Narayan DS, Casson RJ, Ebneter A, Chidlow G, Grace PM, Hutchinson MR, Wood JP. Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. Clinical & Experimental Ophthalmology. 42: 539-54. PMID 24373007 DOI: 10.1111/ceo.12289  1
2014 Mulholland CV, Somogyi AA, Barratt DT, Coller JK, Hutchinson MR, Jacobson GM, Cursons RT, Sleigh JW. Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia. Journal of Molecular Neuroscience : Mn. 52: 497-506. PMID 24352713 DOI: 10.1007/s12031-013-0201-7  0.64
2014 Hutchinson MR, Watkins LR. Why is neuroimmunopharmacology crucial for the future of addiction research? Neuropharmacology. 76: 218-27. PMID 23764149 DOI: 10.1016/j.neuropharm.2013.05.039  1
2013 Kwok YH, Tuke J, Nicotra LL, Grace PM, Rolan PE, Hutchinson MR. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Plos One. 8: e77799. PMID 24204973 DOI: 10.1371/journal.pone.0077799  1
2013 Della Vedova C, Cathcart S, Dohnalek A, Lee V, Hutchinson MR, Immink MA, Hayball J. Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients. Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La SociéTé Canadienne Pour Le Traitement De La Douleur. 18: 301-6. PMID 23957020  1
2013 Li Y, Coller JK, Hutchinson MR, Klein K, Zanger UM, Stanley NJ, Abell AD, Somogyi AA. The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1264-72. PMID 23550066 DOI: 10.1124/dmd.113.051631  1
2013 Hutchinson MR, Buijs M, Tuke J, Kwok YH, Gentgall M, Williams D, Rolan P. Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain, Behavior, and Immunity. 30: 3-11. PMID 23499731 DOI: 10.1016/j.bbi.2013.03.002  1
2013 Theberge FR, Li X, Kambhampati S, Pickens CL, St Laurent R, Bossert JM, Baumann MH, Hutchinson MR, Rice KC, Watkins LR, Shaham Y. Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry. 73: 729-37. PMID 23384483 DOI: 10.1016/j.biopsych.2012.12.019  1
2013 Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 30: 24-32. PMID 23348028 DOI: 10.1016/j.bbi.2013.01.005  1
2013 Johnson JL, Hutchinson MR, Williams DB, Rolan P. Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia : An International Journal of Headache. 33: 52-64. PMID 23144180 DOI: 10.1177/0333102412467512  1
2013 Wu Y, Hutchinson MR. Therapeutic strategies to treat alcohol-related disorders targeting central immune signaling Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. 535-559. DOI: 10.1007/978-1-4614-4729-0_17  1
2012 Thomas J, Hutchinson MR. Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids. Expert Review of Neurotherapeutics. 12: 1311-24. PMID 23234393 DOI: 10.1586/ern.12.125  1
2012 Jalleh R, Koh K, Choi B, Liu E, Maddison J, Hutchinson MR. Role of microglia and toll-like receptor 4 in the pathophysiology of delirium. Medical Hypotheses. 79: 735-9. PMID 22975447 DOI: 10.1016/j.mehy.2012.08.013  1
2012 Kwok YH, Hutchinson MR, Gentgall MG, Rolan PE. Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. Plos One. 7: e44232. PMID 22937165 DOI: 10.1371/journal.pone.0044232  1
2012 Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, et al. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11187-200. PMID 22895704 DOI: 10.1523/JNEUROSCI.0684-12.2012  1
2012 Grace PM, Hurley D, Barratt DT, Tsykin A, Watkins LR, Rolan PE, Hutchinson MR. Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model. Journal of Neurochemistry. 122: 976-94. PMID 22697386 DOI: 10.1111/j.1471-4159.2012.07833.x  1
2012 Sumracki NM, Hutchinson MR, Gentgall M, Briggs N, Williams DB, Rolan P. The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. Plos One. 7: e38525. PMID 22685578 DOI: 10.1371/journal.pone.0038525  1
2012 Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR. (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain : Official Journal of the American Pain Society. 13: 498-506. PMID 22520687 DOI: 10.1016/j.jpain.2012.02.005  1
2012 Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 109: 6325-30. PMID 22474354 DOI: 10.1073/pnas.1200130109  1
2012 Corrigan F, Hutchinson M. Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling? Expert Review of Clinical Immunology. 8: 201-203. PMID 22390481 DOI: 10.1586/eci.11.99  1
2012 Coller JK, Hutchinson MR. Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology & Therapeutics. 134: 219-45. PMID 22316499 DOI: 10.1016/j.pharmthera.2012.01.008  1
2012 Watkins LR, Hutchinson MR, Johnson KW. Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages". Experimental Neurology. 234: 351-3. PMID 22269389 DOI: 10.1016/j.expneurol.2012.01.006  1
2012 Nicotra L, Loram LC, Watkins LR, Hutchinson MR. Toll-like receptors in chronic pain. Experimental Neurology. 234: 316-29. PMID 22001158 DOI: 10.1016/j.expneurol.2011.09.038  1
2012 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Coller JK, Rice KC, Watkins LR, Somogyi AA, Hutchinson MR. Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology. 165: 1319-29. PMID 21955045 DOI: 10.1111/j.1476-5381.2011.01572.x  1
2011 Schwarz JM, Hutchinson MR, Bilbo SD. Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17835-47. PMID 22159099 DOI: 10.1523/JNEUROSCI.3297-11.2011  1
2011 Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews. 63: 772-810. PMID 21752874 DOI: 10.1124/pr.110.004135  1
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. Chembiochem : a European Journal of Chemical Biology. 12: 1827-31. PMID 21678541 DOI: 10.1002/cbic.201100211  1
2011 Grace PM, Rolan PE, Hutchinson MR. Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain, Behavior, and Immunity. 25: 1322-32. PMID 21496480 DOI: 10.1016/j.bbi.2011.04.003  1
2011 Liu L, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR. Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains. Brain, Behavior, and Immunity. 25: 1223-32. PMID 21447380 DOI: 10.1016/j.bbi.2011.03.016  1
2011 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Robertson SA, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR. Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain, Behavior, and Immunity. 25: S155-64. PMID 21276848 DOI: 10.1016/j.bbi.2011.01.012  1
2011 Grace PM, Hutchinson MR, Bishop A, Somogyi AA, Mayrhofer G, Rolan PE. Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain. Brain, Behavior, and Immunity. 25: 503-13. PMID 21134441 DOI: 10.1016/j.bbi.2010.11.018  1
2011 Sumracki NM, Nicotra L, Kwok YH, Liu L, Van Steeg K, R.Watkins L, Hutchinson MR. The future: New concepts and potential therapies Neuropathic Pain: Causes, Management, and Understanding. 341-356. DOI: 10.1017/CBO9781139152211.030  1
2010 Grace PM, Hutchinson MR, Manavis J, Somogyi AA, Rolan PE. A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity. Journal of Neuroscience Methods. 193: 47-53. PMID 20817038 DOI: 10.1016/j.jneumeth.2010.08.025  1
2010 Joce C, Stahl JA, Shridhar M, Hutchinson MR, Watkins LR, Fedichev PO, Yin H. Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters. 20: 5411-3. PMID 20709548 DOI: 10.1016/j.bmcl.2010.07.103  1
2010 Stanley NJ, Hutchinson MR, Kvist T, Nielsen B, Mathiesen JM, Bräuner-Osborne H, Avery TD, Tiekink ER, Pedersen DS, Irvine RJ, Abell AD, Taylor DK. A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry. 18: 6089-98. PMID 20638290 DOI: 10.1016/j.bmc.2010.06.051  1
2010 Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry. 114: 13-27. PMID 20402965 DOI: 10.1111/j.1471-4159.2010.06736.x  1
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/j.neuroscience.2010.03.067  1
2010 Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience. 167: 880-93. PMID 20178837 DOI: 10.1016/j.neuroscience.2010.02.011  1
2010 Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience. 165: 569-83. PMID 19833175 DOI: 10.1016/j.neuroscience.2009.10.011  1
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/j.bbi.2009.08.004  1
2009 Rolan P, Hutchinson MR, Johnson KW. Ibudilast: A review of its pharmacology, efficacy and safety in respiratory and neurological disease Expert Opinion On Pharmacotherapy. 10: 2897-2904. PMID 19929708 DOI: 10.1517/14656560903426189  1
2009 Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14015-25. PMID 19890011 DOI: 10.1523/JNEUROSCI.3447-09.2009  1
2009 Liu L, Hutchinson MR, White JM, Somogyi AA, Coller JK. Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenetics and Genomics. 19: 869-76. PMID 19801958 DOI: 10.1097/FPC.0b013e328331e68f  1
2009 Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ, Lewis MT, Crysdale NY, Zhang Y, Harrison JA, Maier SF, Rice KC, Watkins LR. Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience. 164: 1821-32. PMID 19788917 DOI: 10.1016/j.neuroscience.2009.09.046  1
2009 Watkins LR, Hutchinson MR, Rice KC, Maier SF. The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends in Pharmacological Sciences. 30: 581-91. PMID 19762094 DOI: 10.1016/j.tips.2009.08.002  1
2009 Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain : a Journal of Neurology. 132: 2478-86. PMID 19567702 DOI: 10.1093/brain/awp177  1
2009 Bland ST, Hutchinson MR, Maier SF, Watkins LR, Johnson KW. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, Behavior, and Immunity. 23: 492-7. PMID 19486648 DOI: 10.1016/j.bbi.2009.01.014  1
2009 Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H. A peptide antagonist of the TLR4-MD2 interaction. Chembiochem : a European Journal of Chemical Biology. 10: 645-9. PMID 19184989 DOI: 10.1002/cbic.200800769  1
2009 Hutchinson MR, Lewis SS, Coats BD, Skyba DA, Crysdale NY, Berkelhammer DL, Brzeski A, Northcutt A, Vietz CM, Judd CM, Maier SF, Watkins LR, Johnson KW. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain, Behavior, and Immunity. 23: 240-50. PMID 18938237 DOI: 10.1016/j.bbi.2008.09.012  1
2008 Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR. Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain, Behavior, and Immunity. 22: 1248-56. PMID 18706994 DOI: 10.1016/j.bbi.2008.07.008  1
2008 Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). The European Journal of Neuroscience. 28: 20-9. PMID 18662331 DOI: 10.1111/j.1460-9568.2008.06321.x  1
2008 Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain, Behavior, and Immunity. 22: 1178-89. PMID 18599265 DOI: 10.1016/j.bbi.2008.05.004  1
2007 Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. Thescientificworldjournal. 7: 98-111. PMID 17982582 DOI: 10.1100/tsw.2007.230  1
2007 Watkins LR, Hutchinson MR, Milligan ED, Maier SF. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews. 56: 148-69. PMID 17706291 DOI: 10.1016/j.brainresrev.2007.06.006  1
2007 Ledeboer A, Hutchinson MR, Watkins LR, Johnson KW. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion On Investigational Drugs. 16: 935-50. PMID 17594181 DOI: 10.1517/13543784.16.7.935  1
2007 Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology. 191: 909-17. PMID 17211647 DOI: 10.1007/s00213-006-0678-7  1
2007 Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain, Behavior, and Immunity. 21: 131-46. PMID 17175134 DOI: 10.1016/j.bbi.2006.10.011  1
2007 Watkins LR, Wieseler-Frank J, Hutchinson MR, Ledeboer A, Spataro L, Milligan ED, Sloane EM, Maier SF. Neuroimmune interactions and pain: The role of immune and glial cells Psychoneuroimmunology, Two-Volume Set. 1: 393-414. DOI: 10.1016/B978-012088576-3/50023-X  1
2005 Watkins LR, Hutchinson MR, Johnston IN, Maier SF. Glia: novel counter-regulators of opioid analgesia. Trends in Neurosciences. 28: 661-9. PMID 16246435 DOI: 10.1016/j.tins.2005.10.001  1
2005 Hutchinson MR, Somogyi AA. Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids. International Immunopharmacology. 5: 1713-22. PMID 16102521 DOI: 10.1016/j.intimp.2005.05.006  1
2004 Hutchinson MR, Somogyi AA. (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone. International Immunopharmacology. 4: 1525-30. PMID 15351321 DOI: 10.1016/j.intimp.2004.07.011  1
2004 Hutchinson MR, La Vincente SF, Somogyi AA. In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance. Pain. 110: 751-5. PMID 15288416 DOI: 10.1016/j.pain.2004.05.017  1
2004 Hutchinson MR, Somogyi AA. Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. European Journal of Pharmacology. 494: 251-62. PMID 15212982 DOI: 10.1016/j.ejphar.2004.04.049  1
2004 Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA. CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British Journal of Clinical Pharmacology. 57: 287-97. PMID 14998425 DOI: 10.1046/j.1365-2125.2003.02002.x  1
2003 Menelaou A, Hutchinson MR, Quinn I, Christensen A, Somogyi AA. Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 785: 81-8. PMID 12535841 DOI: 10.1016/S1570-0232(02)00856-5  1
2002 Hutchinson MR, Somogyi AA. Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. European Journal of Pharmacology. 453: 27-32. PMID 12393056 DOI: 10.1016/S0014-2999(02)02365-8  1
1995 Hutchinson MR, Ireland ML. Knee injuries in female athletes. Sports Medicine (Auckland, N.Z.). 19: 288-302. PMID 7604201  0.01
1981 Mueller GL, McKenna TJ, Kelly G, O'Day DM, Hollifield JW, Pidgeon C, Hutchinson M, Rabin D. Papilledema in two patients with acromegaly and intrasellar pituitary tumors Archives of Internal Medicine. 141: 1491-1495. PMID 7283561 DOI: 10.1001/archinte.141.11.1491  1
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