Tally M. Largent-Milnes - Publications

Physiology and Pharmacology Oregon Health and Science University, Portland, OR 
Pain, opioids, systems pharmacology, neuroscience

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kwak EA, Pan CC, Ramonett A, Kumar S, Cruz-Flores P, Ahmed T, Ortiz HR, Lochhead JJ, Ellis NA, Mouneimne G, Georgieva TG, Lee YS, Vanderah TW, Largent-Milnes T, Mohler PJ, et al. β-spectrin as a stalk cell-intrinsic regulator of VEGF signaling. Nature Communications. 13: 1326. PMID 35288568 DOI: 10.1038/s41467-022-28933-1  0.609
2021 Martin L, Ibrahim M, Gomez K, Yu J, Cai S, Chew LA, Bellampalli SS, Moutal A, Largent-Milnes T, Porreca F, Khanna R, Olivera BM, Patwardhan A. Conotoxin contulakin-G engages a neurotensin receptor 2 /R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception. Pain. PMID 35050960 DOI: 10.1097/j.pain.0000000000002561  0.613
2021 Wiese BM, Liktor-Busa E, Couture SA, Nikas SP, Ji L, Liu Y, Makriyannis A, Spigelman I, Vanderah TW, Largent-Milnes TM. Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression. Cannabis and Cannabinoid Research. PMID 34935460 DOI: 10.1089/can.2021.0090  0.675
2021 Levine A, Liktor-Busa E, Lipinski AA, Couture S, Balasubramanian S, Aicher SA, Langlais PR, Vanderah TW, Largent-Milnes TM. Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats. Biology of Sex Differences. 12: 60. PMID 34749819 DOI: 10.1186/s13293-021-00402-2  0.763
2021 Ramonett A, Kwak EA, Ahmed T, Flores PC, Ortiz HR, Lee YS, Vanderah TW, Largent-Milnes T, Kashatus DF, Langlais PR, Mythreye K, Lee NY. Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport. Molecular Biology of the Cell. mbcE21060286. PMID 34705526 DOI: 10.1091/mbc.E21-06-0286  0.604
2021 Liktor-Busa E, Keresztes A, LaVigne J, Streicher JM, Largent-Milnes TM. Analgesic Potential of Terpenes Derived from . Pharmacological Reviews. 73: 98-126. PMID 34663685 DOI: 10.1124/pharmrev.120.000046  0.327
2021 Martin LF, Moutal A, Cheng K, Washington SM, Calligaro H, Goel V, Kranz T, Largent-Milnes TM, Khanna R, Patwardhan A, Ibrahim MM. Green light antinociceptive and reversal of thermal and mechanical hypersensitivity effects rely on endogenous opioid system stimulation. The Journal of Pain. PMID 34157406 DOI: 10.1016/j.jpain.2021.05.006  0.345
2021 Zhang H, Lipinski AA, Liktor-Busa E, Smith AF, Moutal A, Khanna R, Langlais PR, Largent-Milnes TM, Vanderah TW. The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area. Frontiers in Pharmacology. 12: 632757. PMID 33953672 DOI: 10.3389/fphar.2021.632757  0.697
2021 Blawn KT, Kellohen KL, Galloway EA, Wahl J, Vivek A, Verkhovsky VG, Barker NK, Cottier KE, Vallecillo TG, Langlais PR, Liktor-Busa E, Vanderah TW, Largent-Milnes TM. Sex hormones regulate NHE1 functional expression and brain endothelial proteome to control paracellular integrity of the blood endothelial barrier. Brain Research. 147448. PMID 33771519 DOI: 10.1016/j.brainres.2021.147448  0.752
2020 Wiese BM, Liktor-Busa E, Levine A, Couture SA, Nikas SP, Ji L, Liu Y, Mackie K, Makriyannis A, Largent-Milnes TM, Vanderah TW. Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression. Cannabis and Cannabinoid Research. PMID 33998869 DOI: 10.1089/can.2020.0076  0.68
2020 Levine A, Liktor-Busa E, Karlage KL, Giancotti L, Salvemini D, Vanderah TW, Largent-Milnes TM. DAGLα Inhibition as a Non-invasive and Translational Model of Episodic Headache. Frontiers in Pharmacology. 11: 615028. PMID 33584293 DOI: 10.3389/fphar.2020.615028  0.68
2020 Levine A, Vanderah TW, Largent-Milnes TM. An underrepresented majority: A systematic review utilizing allodynic criteria to examine the present scarcity of discrete animal models for episodic migraine. Cephalalgia : An International Journal of Headache. 333102420966984. PMID 33131303 DOI: 10.1177/0333102420966984  0.614
2020 Stine C, Coleman DL, Flohrschutz AT, Thompson AL, Mishra S, Blagg BS, Largent-Milnes TM, Lei W, Streicher JM. Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models. Pain. 161: 1798-1807. PMID 32701840 DOI: 10.1097/J.Pain.0000000000001886  0.449
2020 Vekariya RH, Lei W, Ray A, Sainai SK, Zhang S, Molnar G, Barlow D, Karlage KL, Bilsky E, Houseknecht K, Largent-Milnes TM, Streicher JM, Ananthan S. Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a Mu Opioid Receptor Agonist/Delta Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects. Journal of Medicinal Chemistry. PMID 32530286 DOI: 10.1021/Acs.Jmedchem.0C00503  0.417
2020 Liktor-Busa E, Blawn KT, Kellohen KL, Wiese BM, Verkhovsky V, Wahl J, Vivek A, Palomino SM, Davis TP, Vanderah TW, Largent-Milnes TM. Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake. Plos One. 15: e0227463. PMID 32469979 DOI: 10.1371/Journal.Pone.0227463  0.664
2020 Doyle TM, Largent-Milnes TM, Chen Z, Staikopoulos V, Esposito E, Delgarno R, Fan C, Tosh DK, Cuzzocrea S, Jacobson KA, Trang T, Hutchinson MR, Bennett GJ, Vanderah TW, Salvemini D. The Journal of Pharmacology and Experimental Therapeutics. PMID 32434943 DOI: 10.1124/Jpet.120.000004  0.723
2020 Lucarini E, Coppi E, Micheli L, Parisio C, Vona A, Cherchi F, Pugliese AM, Pedata F, Failli P, Palomino S, Wahl J, Largent-Milnes TM, Vanderah TW, Tosh DK, Jacobson KA, et al. Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels. Pain. PMID 32379223 DOI: 10.1097/J.Pain.0000000000001905  0.731
2020 Doyle TM, Janes K, Chen Z, Grace PM, Esposito E, Cuzzocrea S, Largent-Milnes TM, Neumann WL, Watkins LR, Spiegel S, Vanderah TW, Salvemini D. Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents. Pain. PMID 32301840 DOI: 10.1097/J.Pain.0000000000001888  0.75
2020 Stine C, Coleman DL, Flohrschutz AT, Thompson AL, Mishra S, Blagg BS, Largent-Milnes TM, Lei W, Streicher JM. Heat shock protein 90 inhibitors block the anti-nociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models. Pain. PMID 32301839 DOI: 10.1097/j.pain.0000000000001886  0.325
2020 Thompson AL, Grenald S, Ciccone H, BassiriRad N, Niphakis M, Cravatt B, Largent-Milnes TM, Vanderah TW. The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 32054717 DOI: 10.1124/Jpet.119.262337  0.725
2020 Smith A, Flohrschutz A, Riegel A, Largent-Milnes T, Vanderah T. Functional Connectivity of Prelimic Prefrontal Cortex and Rostral Ventromedial Medulla for Descending Pain Modulation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03633  0.675
2019 Zhang H, Largent-Milnes TM, Vanderah TW. Glial Neuroimmune Signaling in Opioid Reward. Brain Research Bulletin. PMID 31790721 DOI: 10.1016/J.Brainresbull.2019.11.012  0.713
2019 Moutal A, Luo S, Largent-Milnes TM, Vanderah TW, Khanna R. Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiology of Pain (Cambridge, Mass.). 5. PMID 31080913 DOI: 10.1016/J.Ynpai.2018.07.003  0.707
2019 Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D. Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068460 DOI: 10.1073/Pnas.1820466116  0.741
2019 Thompson AL, Largent-Milnes TM, Vanderah TW. Animal Models for the Study of Bone-Derived Pain. Methods in Molecular Biology (Clifton, N.J.). 1914: 391-407. PMID 30729479 DOI: 10.1007/978-1-4939-8997-3_23  0.709
2019 Moutal A, Dustrude ET, Largent-Milnes TM, Vanderah TW, Khanna M, Khanna R. Blocking CRMP2 SUMOylation reverses neuropathic pain. Molecular Psychiatry. 23: 2119-2121. PMID 28533518 DOI: 10.1038/Mp.2017.117  0.652
2018 Cottier KE, Galloway EA, Calabrese EC, Tome ME, Liktor-Busa E, Kim J, Davis TP, Vanderah TW, Largent-Milnes TM. Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery. Eneuro. 5. PMID 30073201 DOI: 10.1523/ENEURO.0116-18.2018  0.777
2018 Zhang H, Lund DM, Ciccone HA, Staatz WD, Ibrahim MM, Largent-Milnes TM, Seltzman HH, Spigelman I, Vanderah TW. A peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain. Pain. PMID 29781960 DOI: 10.1097/J.Pain.0000000000001278  0.764
2018 Pandit V, Khan M, Zakaria ER, Largent-Milnes TM, Hamidi M, O'Keeffe T, Vanderah TW, Joseph B. Continuous Remote Ischemic Conditioning Attenuates Cognitive and Motor Deficits From Moderate Traumatic Brain Injury. The Journal of Trauma and Acute Care Surgery. PMID 29443855 DOI: 10.1097/Ta.0000000000001835  0.631
2018 Schaefer CP, Arkwright NB, Jacobs LM, Jarvis CK, Hunn KC, Largent-Milnes TM, Tome ME, Davis TP. Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels. Plos One. 13: e0192340. PMID 29414996 DOI: 10.1371/Journal.Pone.0192340  0.449
2018 Edwards KA, Havelin JJ, Mcintosh MI, Ciccone HA, Pangilinan K, Imbert I, Largent-Milnes TM, King T, Vanderah TW, Streicher JM. A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. The Journal of Pain : Official Journal of the American Pain Society. PMID 29371114 DOI: 10.1016/J.Jpain.2018.01.002  0.744
2018 Galloway EA, Cottier KE, Kim J, Vallecillo T, Davis TP, Vanderah TW, Largent-Milnes TM. Role of Sex Hormones in Regulation of Sodium‐Proton Exchanger NHE1: Implications for Migraine The Faseb Journal. 32. DOI: 10.1096/Fasebj.2018.32.1_Supplement.533.60  0.746
2017 Sandweiss AJ, Cottier KE, McIntosh MI, Dussor G, Davis TP, Vanderah TW, Largent-Milnes TM. 17-β-Estradiol induces spreading depression and pain behavior in alert female rats. Oncotarget. 8: 114109-114122. PMID 29371973 DOI: 10.18632/Oncotarget.23141  0.771
2017 Malekzadeh P, Hu J, Sandweiss AJ, Ameli N, Bierny P, Largent-Milnes TM, Vanderah TW, Shirazi F. Effect of Centruroides antivenom on reversal of methamphetamine-induced hyperkinesis and hyperthermia in rats. Journal of Pharmaceutics & Pharmacology. 5. PMID 29354652 DOI: 10.13188/2327-204X.1000020  0.757
2017 Sandweiss AJ, Azim A, Ibraheem K, Largent-Milnes TM, Rhee P, Vanderah TW, Joseph B. Remote Ischemic Conditioning Preserves Cognition and Motor Coordination in a Mouse Model of Traumatic Brain Injury. The Journal of Trauma and Acute Care Surgery. PMID 28609381 DOI: 10.1097/Ta.0000000000001626  0.751
2017 Grenald SA, Doyle TM, Zhang H, Slosky LM, Chen Z, Largent-Milnes TM, Spiegel S, Vanderah TW, Salvemini D. Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation. Pain. PMID 28570482 DOI: 10.1097/J.Pain.0000000000000965  0.806
2017 Sandweiss AJ, McIntosh MI, Moutal A, Davidson-Knapp R, Hu J, Giri AK, Yamamoto T, Hruby VJ, Khanna R, Largent-Milnes TM, Vanderah TW. Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential. Molecular Psychiatry. PMID 28485408 DOI: 10.1038/Mp.2017.102  0.818
2017 Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 158: 347-360. PMID 28092651 DOI: 10.1097/J.Pain.0000000000000767  0.788
2017 Cottier K, Galoway E, Kim J, Vanderah T, Davis T, Largent-Milnes T. (143) Transient Decreases in Blood-Brain Barrier Integrity Correspond with Facial Allodynia Duration in a Model of Migraine with Aura The Journal of Pain. 18: S12. DOI: 10.1016/J.Jpain.2017.02.049  0.753
2016 Grenald SA, Young MA, Wang Y, Ossipov MH, Ibrahim MM, Largent-Milnes TM, Vanderah TW. Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists. Neuropharmacology. PMID 28007501 DOI: 10.1016/J.Neuropharm.2016.12.008  0.753
2016 Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/Acs.Jmedchem.6B01411  0.796
2016 Forte BL, Slosky LM, Zhang H, Arnold M, Staatz WD, Hay M, Largent-Milnes TM, Vanderah TW. Angiotensin-(1-7)/Mas Receptor as an Antinociceptive Agent in Cancer-Induced Bone Pain. Pain. PMID 27541850 DOI: 10.1097/J.Pain.0000000000000690  0.819
2016 Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, Forte BL, Staatz WD, Bui L, Neumann WL, Mantyh PW, Salvemini D, Largent-Milnes TM, Vanderah TW. The Cystine/Glutamate Antiporter System xc- Drives Breast Tumor Cell Glutamate Release and Cancer-Induced Bone Pain. Pain. PMID 27482630 DOI: 10.1097/J.Pain.0000000000000681  0.789
2015 Deekonda S, Cole J, Sunna S, Rankin D, Largent-Milnes TM, Davis P, BassiriRad NM, Lai J, Vanderah TW, Porecca F, Hruby VJ. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & Medicinal Chemistry Letters. PMID 26611918 DOI: 10.1016/J.Bmcl.2015.10.081  0.736
2015 Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/Acs.Jmedchem.5B01170  0.784
2015 Slosky LM, Largent-Milnes TM, Vanderah TW. Use of Animal Models in Understanding Cancer-induced Bone Pain. Cancer Growth and Metastasis. 8: 47-62. PMID 26339191 DOI: 10.4137/CGM.S21215  0.804
2015 Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/J.Bmcl.2015.07.064  0.789
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/J.Bmc.2015.07.071  0.793
2015 Fawley JA, Hofmann ME, Largent-Milnes TM, Andresen MC. Temperature differentially facilitates spontaneous but not evoked glutamate release from cranial visceral primary afferents. Plos One. 10: e0127764. PMID 25992717 DOI: 10.1371/Journal.Pone.0127764  0.758
2015 François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 156: 1247-64. PMID 25782368 DOI: 10.1097/j.pain.0000000000000147  0.78
2015 Sandweiss A, Skinner D, Vanderah T, Largent-Milnes T. (354) Estrogen induces cortical spreading depression (CSD) associated with migraine aura in awake, freely moving female rats The Journal of Pain. 16: S64. DOI: 10.1016/J.Jpain.2015.01.272  0.759
2015 Slosky L, BassiriRad N, Symons-Liguori A, Forte B, Bui L, Largent-Milnes T, Vanderah T. (277) The cystine-glutamate antiporter system xc- drives tumor cell glutamate release and cancer-induced bone pain The Journal of Pain. 16: S45. DOI: 10.1016/J.Jpain.2015.01.195  0.793
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071  0.76
2014 Grenald SA, Largent-Milnes TM, Vanderah TW. Animal models for opioid addiction drug discovery. Expert Opinion On Drug Discovery. 9: 1345-54. PMID 25307021 DOI: 10.1517/17460441.2014.966076  0.719
2014 Hofmann ME, Largent-Milnes TM, Fawley JA, Andresen MC. External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1. Journal of Neurophysiology. 112: 2697-706. PMID 25185814 DOI: 10.1152/Jn.00316.2014  0.776
2014 Hegarty DM, Hermes SM, Largent-Milnes TM, Aicher SA. Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats. Journal of Chemical Neuroanatomy. 61: 1-12. PMID 24996127 DOI: 10.1016/J.Jchemneu.2014.06.006  0.585
2014 Largent-Milnes TM, Hegarty DM, Aicher SA, Andresen MC. Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons. Journal of Neurophysiology. 111: 2222-31. PMID 24598529 DOI: 10.1152/Jn.00912.2013  0.699
2013 Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/J.Bmcl.2013.06.065  0.786
2013 Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/Jpet.113.205245  0.819
2013 Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, et al. Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 92-107. PMID 22903605 DOI: 10.1002/Jbmr.1732  0.808
2012 Tumati S, Largent-Milnes TM, Keresztes AI, Yamamoto T, Vanderah TW, Roeske WR, Hruby VJ, Varga EV. Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. European Journal of Pharmacology. 684: 64-70. PMID 22724132 DOI: 10.1016/J.Ejphar.2012.03.025  0.773
2012 Tumati S, Largent-Milnes TM, Keresztes A, Ren J, Roeske WR, Vanderah TW, Varga EV. Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. Journal of Neuroimmunology. 244: 23-31. PMID 22285397 DOI: 10.1016/J.Jneuroim.2011.12.021  0.738
2012 Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-Eâ‚‚ in the spinal cord. Pain. 153: 86-94. PMID 22030324 DOI: 10.1016/J.Pain.2011.09.021  0.786
2011 Tumati S, Roeske WR, Largent-Milnes TM, Vanderah TW, Varga EV. Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats. Journal of Neuroscience Methods. 199: 62-8. PMID 21571003 DOI: 10.1016/J.Jneumeth.2011.04.036  0.748
2011 Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/J.Brainres.2011.04.024  0.821
2011 Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/Jm101023R  0.804
2011 Ondoua A, Hanlon K, Largent-Milnes T, Sukhtankar D, King T, Mantyh P, Vanderah T. CB2 receptor agonists act as a disease-modifying treatment by attenuating breast cancer-induced bone pain and improving bone health in a murine model of breast cancer metastases The Journal of Pain. 12: P51. DOI: 10.1016/J.Jpain.2011.02.207  0.792
2010 Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/J.1476-5381.2010.00824.X  0.819
2010 Tumati S, Roeske WR, Largent-Milnes T, Wang R, Vanderah TW, Varga EV. Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA. British Journal of Pharmacology. 161: 51-64. PMID 20718739 DOI: 10.1111/J.1476-5381.2010.00869.X  0.735
2010 Largent-Milnes TM, Vanderah TW. Recently patented and promising ORL-1 ligands: where have we been and where are we going? Expert Opinion On Therapeutic Patents. 20: 291-305. PMID 20180617 DOI: 10.1517/13543771003602004  0.746
2010 Lozano-Ondoua AN, Wright C, Vardanyan A, King T, Largent-Milnes TM, Nelson M, Jimenez-Andrade JM, Mantyh PW, Vanderah TW. A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. Life Sciences. 86: 646-53. PMID 20176037 DOI: 10.1016/J.Lfs.2010.02.014  0.716
2010 Hanlon K, Lozano-Ondoua A, Chandramouli A, Largent-Milnes T, Umaretiya P, Stapleton D, Nelson M, Mantyh P, Vanderah T. Abstract P1-11-23: Cannabinoid Receptor 2 Compounds in the Attenuation of Breast Cancer Cell Proliferation: Mechanisms of Action Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-P1-11-23  0.764
2008 Largent-Milnes TM, Guo W, Wang HY, Burns LH, Vanderah TW. Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling. The Journal of Pain : Official Journal of the American Pain Society. 9: 700-13. PMID 18468954 DOI: 10.1016/J.Jpain.2008.03.005  0.728
2008 Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. European Journal of Pharmacology. 583: 62-72. PMID 18282565 DOI: 10.1016/J.Ejphar.2008.01.011  0.778
2008 Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/Jm070332F  0.804
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