| Year |
Citation |
Score |
| 2023 |
Danelon V, Garret-Thomson SC, Almo SC, Lee FS, Hempstead BL. Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation. Frontiers in Molecular Neuroscience. 16: 1305574. PMID 38106879 DOI: 10.3389/fnmol.2023.1305574 |
0.63 |
|
| 2022 |
Morano NC, Smith RS, Danelon V, Schreiner R, Patel U, Herrera NG, Smith C, Olson SM, Laerke MK, Celikgil A, Garforth SJ, Garrett-Thomson SC, Lee FS, Hempstead BL, Almo SC. Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor. The Journal of Clinical Investigation. PMID 36107635 DOI: 10.1172/JCI157002 |
0.644 |
|
| 2020 |
Wang J, Anastasia A, Bains H, Giza JI, Clossey DG, Deng J, Neubert TA, Rice WJ, Lee FS, Hempstead BL, Bracken C. Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination. Metallomics : Integrated Biometal Science. PMID 32744273 DOI: 10.1039/D0Mt00108B |
0.795 |
|
| 2020 |
Yang J, Ma Q, Dincheva I, Giza J, Jing D, Marinic T, Milner TA, Rajadhyaksha A, Lee FS, Hempstead BL. SorCS2 is required for social memory and trafficking of the NMDA receptor. Molecular Psychiatry. PMID 31988435 DOI: 10.1038/S41380-020-0650-7 |
0.645 |
|
| 2019 |
Kermani P, Hempstead B. BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury. Frontiers in Physiology. 10: 455. PMID 31105581 DOI: 10.3389/Fphys.2019.00455 |
0.437 |
|
| 2018 |
Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, Liston C, Jing D, Hempstead BL, Lee FS. The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 99: 1356. PMID 30236287 DOI: 10.1016/j.neuron.2018.08.041 |
0.731 |
|
| 2018 |
Lee FS, Hempstead BL. New Roles for an Ancient Factor. Trends in Neurosciences. PMID 30219601 DOI: 10.1016/j.tins.2018.08.012 |
0.656 |
|
| 2018 |
Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, Liston C, Jing D, Hempstead BL, Lee FS. The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. PMID 29909994 DOI: 10.1016/J.Neuron.2018.05.024 |
0.792 |
|
| 2018 |
Greenwood SG, Montroull L, Volosin M, Scharfman HE, Teng KK, Light M, Torkin R, Maxfield F, Hempstead BL, Friedman WJ. A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo. Eneuro. 5. PMID 29349290 DOI: 10.1523/ENEURO.0257-17.2017 |
0.748 |
|
| 2017 |
Dincheva I, Yang J, Li A, Marinic T, Freilingsdorf H, Huang C, Casey BJ, Hempstead B, Glatt CE, Lee FS, Bath KG, Jing D. Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. The American Journal of Psychiatry. appiajp201715121592. PMID 29084453 DOI: 10.1176/appi.ajp.2017.15121592 |
0.724 |
|
| 2017 |
Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, ... Hempstead BL, et al. Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29052614 DOI: 10.1038/Npp.2017.252 |
0.321 |
|
| 2017 |
Ma Q, Yang J, Milner TA, Vonsattel JG, Palko ME, Tessarollo L, Hempstead BL. SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. Jci Insight. 2. PMID 28469074 DOI: 10.1172/Jci.Insight.88995 |
0.363 |
|
| 2016 |
Harward SC, Hedrick NG, Hall CE, Parra-Bueno P, Milner TA, Pan E, Laviv T, Hempstead BL, Yasuda R, McNamara JO. Autocrine BDNF-TrkB signalling within a single dendritic spine. Nature. PMID 27680698 DOI: 10.1038/Nature19766 |
0.453 |
|
| 2015 |
Anastasia A, Barker PA, Chao MV, Hempstead BL. Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11911-20. PMID 26311773 DOI: 10.1523/Jneurosci.0591-15.2015 |
0.781 |
|
| 2015 |
Ma Q, Yang J, Li T, Milner TA, Hempstead BL. Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease. Neurobiology of Disease. 82: 466-477. PMID 26282324 DOI: 10.1016/J.Nbd.2015.08.008 |
0.496 |
|
| 2015 |
Song M, Giza J, Proenca CC, Jing D, Elliott M, Dincheva I, Shmelkov SV, Kim J, Schreiner R, Huang SH, Castrén E, Prekeris R, Hempstead BL, Chao MV, Dictenberg JB, et al. Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Developmental Cell. 33: 690-702. PMID 26004511 DOI: 10.1016/J.Devcel.2015.04.009 |
0.773 |
|
| 2015 |
Lee BG, Anastasia A, Hempstead BL, Lee FS, Blendy JA. Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 25744957 DOI: 10.1093/Ntr/Ntv047 |
0.748 |
|
| 2014 |
VonDran MW, LaFrancois J, Padow VA, Friedman WJ, Scharfman HE, Milner TA, Hempstead BL. p75NTR, but not proNGF, is upregulated following status epilepticus in mice. Asn Neuro. 6. PMID 25290065 DOI: 10.1177/1759091414552185 |
0.434 |
|
| 2014 |
Fulmer CG, VonDran MW, Stillman AA, Huang Y, Hempstead BL, Dreyfus CF. Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8186-96. PMID 24920623 DOI: 10.1523/Jneurosci.4267-13.2014 |
0.39 |
|
| 2014 |
Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q, Jing D, Lafrancois JJ, Bath KG, Mark W, Ballon D, Lee FS, Scharfman HE, Hempstead BL. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Reports. 7: 796-806. PMID 24746813 DOI: 10.1016/j.celrep.2014.03.040 |
0.769 |
|
| 2014 |
Hempstead BL. Deciphering proneurotrophin actions. Handbook of Experimental Pharmacology. 220: 17-32. PMID 24668468 DOI: 10.1007/978-3-642-45106-5_2 |
0.487 |
|
| 2014 |
Irmady K, Jackman KA, Padow VA, Shahani N, Martin LA, Cerchietti L, Unsicker K, Iadecola C, Hempstead BL. Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3419-28. PMID 24573298 DOI: 10.1523/Jneurosci.1982-13.2014 |
0.796 |
|
| 2014 |
Anastasia A, Deinhardt K, Wang S, Martin L, Nichol D, Irmady K, Trinh J, Parada L, Rafii S, Hempstead BL, Kermani P. Trkb signaling in pericytes is required for cardiac microvessel stabilization. Plos One. 9: e87406. PMID 24498100 DOI: 10.1371/Journal.Pone.0087406 |
0.782 |
|
| 2014 |
Anastasia A, Deinhardt K, Chao MV, Will NE, Irmady K, Lee FS, Hempstead BL, Bracken C. Corrigendum: Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction Nature Communications. 5. DOI: 10.1038/Ncomms4564 |
0.786 |
|
| 2013 |
Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 155: 1596-609. PMID 24360280 DOI: 10.1016/J.Cell.2013.11.030 |
0.416 |
|
| 2013 |
Anastasia A, Deinhardt K, Chao MV, Will NE, Irmady K, Lee FS, Hempstead BL, Bracken C. Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature Communications. 4: 2490. PMID 24048383 DOI: 10.1038/Ncomms3490 |
0.806 |
|
| 2013 |
Takeda K, Kermani P, Anastasia A, Obinata Y, Hempstead BL, Kurihara H. BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 341-9. PMID 24032685 DOI: 10.1139/Bcb-2013-0005 |
0.717 |
|
| 2013 |
Lorentz CU, Parrish DC, Alston EN, Pellegrino MJ, Woodward WR, Hempstead BL, Habecker BA. Sympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor. Experimental Neurology. 249: 111-9. PMID 24013014 DOI: 10.1016/J.Expneurol.2013.08.015 |
0.378 |
|
| 2012 |
Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, ... Hempstead BL, et al. ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. The Journal of Experimental Medicine. 209: 2291-305. PMID 23091165 DOI: 10.1084/Jem.20111749 |
0.385 |
|
| 2012 |
Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S. Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14080-6. PMID 23055476 DOI: 10.1523/Jneurosci.3359-12.2012 |
0.397 |
|
| 2012 |
Je HS, Yang F, Ji Y, Nagappan G, Hempstead BL, Lu B. Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proceedings of the National Academy of Sciences of the United States of America. 109: 15924-9. PMID 23019376 DOI: 10.1073/Pnas.1207767109 |
0.45 |
|
| 2012 |
Kalous A, Nangle MR, Anastasia A, Hempstead BL, Keast JR. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. Journal of Neurochemistry. 122: 523-36. PMID 22621370 DOI: 10.1111/J.1471-4159.2012.07799.X |
0.751 |
|
| 2012 |
Taylor AR, Gifondorwa DJ, Robinson MB, Strupe JL, Prevette D, Johnson JE, Hempstead B, Oppenheim RW, Milligan CE. Motoneuron programmed cell death in response to proBDNF. Developmental Neurobiology. 72: 699-712. PMID 21834083 DOI: 10.1002/Dneu.20964 |
0.41 |
|
| 2011 |
Deinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA, Chao MV, Hempstead BL. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Science Signaling. 4: ra82. PMID 22155786 DOI: 10.1126/Scisignal.2002060 |
0.81 |
|
| 2011 |
Evans SF, Irmady K, Ostrow K, Kim T, Nykjaer A, Saftig P, Blobel C, Hempstead BL. Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. The Journal of Biological Chemistry. 286: 29556-67. PMID 21730062 DOI: 10.1074/Jbc.M111.219675 |
0.829 |
|
| 2011 |
Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6392-7. PMID 21525279 DOI: 10.1523/Jneurosci.6249-10.2011 |
0.364 |
|
| 2010 |
Song W, Volosin M, Cragnolini AB, Hempstead BL, Friedman WJ. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15608-15. PMID 21084616 DOI: 10.1523/Jneurosci.2581-10.2010 |
0.479 |
|
| 2010 |
Teng KK, Felice S, Kim T, Hempstead BL. Understanding proneurotrophin actions: Recent advances and challenges. Developmental Neurobiology. 70: 350-9. PMID 20186707 DOI: 10.1002/Dneu.20768 |
0.779 |
|
| 2010 |
Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC. Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Journal of Molecular Biology. 396: 967-84. PMID 20036257 DOI: 10.1016/J.Jmb.2009.12.030 |
0.771 |
|
| 2009 |
Greenberg ME, Xu B, Lu B, Hempstead BL. New insights in the biology of BDNF synthesis and release: implications in CNS function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12764-7. PMID 19828787 DOI: 10.1523/Jneurosci.3566-09.2009 |
0.457 |
|
| 2009 |
Hempstead BL. Commentary: Regulating proNGF action: multiple targets for therapeutic intervention. Neurotoxicity Research. 16: 255-60. PMID 19526280 DOI: 10.1007/s12640-009-9054-9 |
0.445 |
|
| 2009 |
Yang F, Je HS, Ji Y, Nagappan G, Hempstead B, Lu B. Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses. The Journal of Cell Biology. 185: 727-41. PMID 19451278 DOI: 10.1083/Jcb.200811147 |
0.387 |
|
| 2009 |
Kim T, Hempstead BL. NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. The Embo Journal. 28: 1612-23. PMID 19407813 DOI: 10.1038/emboj.2009.118 |
0.603 |
|
| 2009 |
Casey BJ, Glatt CE, Tottenham N, Soliman F, Bath K, Amso D, Altemus M, Pattwell S, Jones R, Levita L, McEwen B, Magariños AM, Gunnar M, Thomas KM, Mezey J, ... ... Hempstead BL, et al. Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience. 164: 108-20. PMID 19358879 DOI: 10.1016/J.Neuroscience.2009.03.081 |
0.741 |
|
| 2009 |
Bath KG, Voss HU, Jing D, Anderson S, Hempstead B, Lee FS, Dyke JP, Ballon DJ. Quantitative intact specimen magnetic resonance microscopy at 3.0 T. Magnetic Resonance Imaging. 27: 672-80. PMID 19152774 DOI: 10.1016/J.Mri.2008.11.008 |
0.715 |
|
| 2009 |
Nagappan G, Zaitsev E, Senatorov VV, Yang J, Hempstead BL, Lu B. Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 106: 1267-72. PMID 19147841 DOI: 10.1073/pnas.0807322106 |
0.354 |
|
| 2009 |
Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, Lu B, Hempstead BL. Neuronal release of proBDNF. Nature Neuroscience. 12: 113-5. PMID 19136973 DOI: 10.1038/nn.2244 |
0.717 |
|
| 2008 |
Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, Carter BD, Friedman WJ. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9870-9. PMID 18815271 DOI: 10.1523/Jneurosci.2841-08.2008 |
0.469 |
|
| 2008 |
Chen ZY, Bath K, McEwen B, Hempstead B, Lee F. Impact of genetic variant BDNF (Val66Met) on brain structure and function. Novartis Foundation Symposium. 289: 180-8; discussion 18. PMID 18497103 DOI: 10.1002/9780470751251.Ch14 |
0.776 |
|
| 2008 |
Bath KG, Mandairon N, Jing D, Rajagopal R, Kapoor R, Chen ZY, Khan T, Proenca CC, Kraemer R, Cleland TA, Hempstead BL, Chao MV, Lee FS. Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2383-93. PMID 18322085 DOI: 10.1523/Jneurosci.4387-07.2008 |
0.808 |
|
| 2008 |
Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C. Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. The Journal of Investigative Dermatology. 128: 2031-40. PMID 18305571 DOI: 10.1038/jid.2008.21 |
0.412 |
|
| 2007 |
Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience. 10: 1449-57. PMID 17934455 DOI: 10.1038/Nn2000 |
0.782 |
|
| 2007 |
Johnston AL, Lun X, Rahn JJ, Liacini A, Wang L, Hamilton MG, Parney IF, Hempstead BL, Robbins SM, Forsyth PA, Senger DL. The p75 neurotrophin receptor is a central regulator of glioma invasion. Plos Biology. 5: e212. PMID 17696644 DOI: 10.1371/Journal.Pbio.0050212 |
0.346 |
|
| 2007 |
Kermani P, Hempstead B. Brain-Derived Neurotrophic Factor: A Newly Described Mediator of Angiogenesis Trends in Cardiovascular Medicine. 17: 140-143. PMID 17482097 DOI: 10.1016/J.Tcm.2007.03.002 |
0.387 |
|
| 2007 |
Domeniconi M, Hempstead BL, Chao MV. Pro-NGF secreted by astrocytes promotes motor neuron cell death. Molecular and Cellular Neurosciences. 34: 271-9. PMID 17188890 DOI: 10.1016/J.Mcn.2006.11.005 |
0.808 |
|
| 2007 |
Kraemer R, Novikov N, Hempstead B. Cytokine‐induced expression of the p75 neurotrophin receptor (p75) in vascular smooth muscle cells (p75) The Faseb Journal. 21. DOI: 10.1096/FASEBJ.21.5.A68-C |
0.333 |
|
| 2006 |
Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (New York, N.Y.). 314: 140-3. PMID 17023662 DOI: 10.1126/Science.1129663 |
0.772 |
|
| 2006 |
Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL. TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Developmental Biology. 299: 455-65. PMID 17005175 DOI: 10.1016/J.Ydbio.2006.08.025 |
0.72 |
|
| 2006 |
Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7756-66. PMID 16855103 DOI: 10.1523/Jneurosci.1560-06.2006 |
0.792 |
|
| 2006 |
Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM. Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5288-300. PMID 16707781 DOI: 10.1523/JNEUROSCI.3547-05.2006 |
0.419 |
|
| 2006 |
Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 50: 219-32. PMID 16630834 DOI: 10.1016/J.Neuron.2006.03.011 |
0.745 |
|
| 2006 |
Hempstead BL. Dissecting the diverse actions of pro- and mature neurotrophins. Current Alzheimer Research. 3: 19-24. PMID 16472198 DOI: 10.2174/156720506775697061 |
0.519 |
|
| 2005 |
Kraemer R, Baker PJ, Kent KC, Ye Y, Han JJ, Tejada R, Silane M, Upmacis R, Deeb R, Chen Y, Levine DM, Hempstead B. Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. Circulation. 112: 3644-53. PMID 16330706 DOI: 10.1161/CIRCULATIONAHA.105.587980 |
0.39 |
|
| 2005 |
Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience. 8: 1069-77. PMID 16025106 DOI: 10.1038/Nn1510 |
0.447 |
|
| 2005 |
Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, Nykjaer A, Hempstead BL, Lee FS. Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6156-66. PMID 15987945 DOI: 10.1523/Jneurosci.1017-05.2005 |
0.716 |
|
| 2005 |
Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, Kraemer RT, Nykjaer A, Hempstead BL. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5455-63. PMID 15930396 DOI: 10.1523/Jneurosci.5123-04.2005 |
0.831 |
|
| 2005 |
Zhang F, Cheng J, Lam G, Jin DK, Vincent L, Hackett NR, Wang S, Young LM, Hempstead B, Crystal RG, Rafii S. Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. Circulation Research. 96: 950-7. PMID 15831817 DOI: 10.1161/01.Res.0000165867.95291.7B |
0.649 |
|
| 2005 |
Hempstead BL. Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 5645-6. PMID 15827113 DOI: 10.1073/pnas.0501718102 |
0.414 |
|
| 2005 |
Kermani P, Rafii D, Jin DK, Whitlock P, Schaffer W, Chiang A, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Rafii S, Hempstead BL. Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. The Journal of Clinical Investigation. 115: 653-63. PMID 15765148 DOI: 10.1172/jci22655 |
0.444 |
|
| 2005 |
Klein M, Hempstead BL, Teng KK. Activation of STAT5-dependent transcription by the neurotrophin receptor Trk. Journal of Neurobiology. 63: 159-71. PMID 15702476 DOI: 10.1002/Neu.20124 |
0.762 |
|
| 2005 |
Pedraza CE, Podlesniy P, Vidal N, Arévalo JC, Lee R, Hempstead B, Ferrer I, Iglesias M, Espinet C. Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. The American Journal of Pathology. 166: 533-43. PMID 15681836 DOI: 10.1016/S0002-9440(10)62275-4 |
0.647 |
|
| 2005 |
Linggi MS, Burke TL, Williams BB, Harrington A, Kraemer R, Hempstead BL, Yoon SO, Carter BD. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. The Journal of Biological Chemistry. 280: 13801-8. PMID 15668238 DOI: 10.1074/jbc.M410435200 |
0.478 |
|
| 2005 |
Pearse RN, Swendeman SL, Li Y, Rafii D, Hempstead BL. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 105: 4429-36. PMID 15657181 DOI: 10.1182/blood-2004-08-3096 |
0.437 |
|
| 2004 |
Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, Teng KK, Yung WH, Hempstead BL, Lu B. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (New York, N.Y.). 306: 487-91. PMID 15486301 DOI: 10.1126/Science.1100135 |
0.711 |
|
| 2004 |
Srinivasan B, Roque CH, Hempstead BL, Al-Ubaidi MR, Roque RS. Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor. The Journal of Biological Chemistry. 279: 41839-45. PMID 15277529 DOI: 10.1074/Jbc.M402872200 |
0.423 |
|
| 2004 |
Kim H, Li Q, Hempstead BL, Madri JA. Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. The Journal of Biological Chemistry. 279: 33538-46. PMID 15169782 DOI: 10.1074/Jbc.M404115200 |
0.482 |
|
| 2004 |
Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4401-11. PMID 15128854 DOI: 10.1523/Jneurosci.0348-04.2004 |
0.818 |
|
| 2004 |
Hempstead BL. Sculpting organ innervation. The Journal of Clinical Investigation. 113: 811-3. PMID 15067313 DOI: 10.1172/JCI21309 |
0.396 |
|
| 2004 |
Murray SS, Perez P, Lee R, Hempstead BL, Chao MV. A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2742-9. PMID 15028767 DOI: 10.1523/Jneurosci.3960-03.2004 |
0.721 |
|
| 2004 |
Harrington AW, Leiner B, Blechschmitt C, Arevalo JC, Lee R, Mörl K, Meyer M, Hempstead BL, Yoon SO, Giehl KM. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proceedings of the National Academy of Sciences of the United States of America. 101: 6226-30. PMID 15026568 DOI: 10.1073/Pnas.0305755101 |
0.645 |
|
| 2004 |
Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 427: 843-8. PMID 14985763 DOI: 10.1038/Nature02319 |
0.822 |
|
| 2004 |
Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological systems. Cellular and Molecular Life Sciences : Cmls. 61: 35-48. PMID 14704852 DOI: 10.1007/s00018-003-3099-3 |
0.752 |
|
| 2004 |
Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. The Journal of Clinical Investigation. 113: 38-48. PMID 14702107 DOI: 10.1172/Jci19684 |
0.302 |
|
| 2004 |
Cheng J, Zhang F, Lam G, Hackett NR, Wang S, Amano H, Shmelkov SV, Young LM, Hempstead B, Crystal RG, Rafii S. Adenovirus Vector E4 Gene Promotes Angiogenesis through Modulation of Junctional Connexin 40 and 43 Expression. Blood. 104: 5277-5277. DOI: 10.1182/Blood.V104.11.5277.5277 |
0.647 |
|
| 2003 |
Kraemer R, Hempstead BL. Neurotrophins: novel mediators of angiogenesis. Frontiers in Bioscience : a Journal and Virtual Library. 8: s1181-6. PMID 12957860 DOI: 10.1096/Fasebj.21.5.A197-C |
0.364 |
|
| 2003 |
Shonukan T, Bagayogo I, McCrea PD, Chao M, Hempstead B. Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin Oncogene. 22: 3616-3623. PMID 12789270 DOI: 10.1038/Sj.Onc.1206561 |
0.628 |
|
| 2002 |
Hempstead BL, Salzer JL. Neurobiology. A glial spin on neurotrophins. Science (New York, N.Y.). 298: 1184-6. PMID 12424359 DOI: 10.1126/Science.1078709 |
0.354 |
|
| 2002 |
Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 36: 375-86. PMID 12408842 DOI: 10.1016/S0896-6273(02)01005-X |
0.566 |
|
| 2002 |
Hempstead BL. The many faces of p75NTR. Current Opinion in Neurobiology. 12: 260-7. PMID 12049931 DOI: 10.1016/S0959-4388(02)00321-5 |
0.405 |
|
| 2002 |
Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT. Erythropoietin receptor signalling is required for normal brain development. Development (Cambridge, England). 129: 505-16. PMID 11807041 |
0.349 |
|
| 2001 |
Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science (New York, N.Y.). 294: 1945-8. PMID 11729324 DOI: 10.1126/Science.1065057 |
0.814 |
|
| 2001 |
Esposito D, Patel P, Stephens RM, Perez P, Chao MV, Kaplan DR, Hempstead BL. The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor. The Journal of Biological Chemistry. 276: 32687-95. PMID 11435417 DOI: 10.1074/Jbc.M011674200 |
0.6 |
|
| 2000 |
Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development (Cambridge, England). 127: 4531-40. PMID 11023857 |
0.354 |
|
| 2000 |
Lin MI, Das I, Schwartz GM, Tsoulfas P, Mikawa T, Hempstead BL. Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. Developmental Biology. 226: 180-91. PMID 11023679 DOI: 10.1006/Dbio.2000.9850 |
0.367 |
|
| 2000 |
Wang S, Bray P, McCaffrey T, March K, Hempstead BL, Kraemer R. p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells. The American Journal of Pathology. 157: 1247-58. PMID 11021829 DOI: 10.1016/S0002-9440(10)64640-8 |
0.678 |
|
| 2000 |
Arevalo JC, Conde B, Hempstead BL, Chao MV, Martin-Zanca D, Perez P. TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor. Molecular and Cellular Biology. 20: 5908-16. PMID 10913174 DOI: 10.1128/Mcb.20.16.5908-5916.2000 |
0.585 |
|
| 2000 |
Escalante M, Courtney J, Chin WG, Teng KK, Kim JI, Fajardo JE, Mayer BJ, Hempstead BL, Birge RB. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. The Journal of Biological Chemistry. 275: 24787-97. PMID 10825157 DOI: 10.1074/Jbc.M000711200 |
0.732 |
|
| 2000 |
Escalante M, Courtney J, Chin WG, Teng KK, Kim JI, Fajardo JE, Mayer BJ, Hempstead BL, Birge RB.. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. J Biol Chem. 275: 24787. PMID 10825157 |
0.714 |
|
| 2000 |
Das I, Sparrow JR, Lin MI, Shih E, Mikawa T, Hempstead BL. Trk C signaling is required for retinal progenitor cell proliferation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2887-95. PMID 10751441 DOI: 10.1523/Jneurosci.20-08-02887.2000 |
0.372 |
|
| 1999 |
Teng KK, Esposito DK, Schwartz GD, Lander HM, Hempstead BL. Activation of c-Ha-Ras by nitric oxide modulates survival responsiveness in neuronal PC12 cells. The Journal of Biological Chemistry. 274: 37315-20. PMID 10601298 DOI: 10.1074/Jbc.274.52.37315 |
0.713 |
|
| 1999 |
Kraemer R, Nguyen H, March KL, Hempstead B. NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1041-1050. PMID 10195934 DOI: 10.1161/01.Atv.19.4.1041 |
0.426 |
|
| 1998 |
Tessarollo L, Hempstead BL. Regulation of cardiac development by receptor tyrosine kinases. Trends in Cardiovascular Medicine. 8: 34-40. PMID 21235910 DOI: 10.1016/S1050-1738(97)00119-9 |
0.436 |
|
| 1997 |
Glassman RH, Hempstead BL, Staiano-Coico L, Steiner MG, Hanafusa H, Birge RB. v-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells. Cell Death and Differentiation. 4: 82-93. PMID 16465214 DOI: 10.1038/sj.cdd.4400203 |
0.425 |
|
| 1997 |
Das I, Hempstead BL, MacLeish PR, Sparrow JR. Immunohistochemical analysis of the neurotrophins BDNF and NT-3 and their receptors trk B, trk C, and p75 in the developing chick retina. Visual Neuroscience. 14: 835-42. PMID 9364722 DOI: 10.1017/S0952523800011573 |
0.436 |
|
| 1997 |
Hempstead BL, Chao MV. Entering the domain of neurotrophin binding. Nature Biotechnology. 15: 623-4. PMID 9219261 DOI: 10.1038/Nbt0797-623 |
0.49 |
|
| 1997 |
Rydén M, Hempstead B, Ibáñez CF. Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor. The Journal of Biological Chemistry. 272: 16322-8. PMID 9195937 DOI: 10.1074/Jbc.272.26.16322 |
0.497 |
|
| 1996 |
Teng KK, Courtney JC, Henegouwen PB, Birge RB, Hempstead BL. Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells Molecular and Cellular Neurosciences. 8: 157-70. PMID 8954630 DOI: 10.1006/Mcne.1996.0054 |
0.749 |
|
| 1996 |
Teng KK, Courtney JC, van Bergen en Henegouwen P, Birge RB, Hempstead BL. Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-Crk in PC12 cells. Molecular and Cellular Neurosciences. 8: 157-70. PMID 8918832 |
0.303 |
|
| 1996 |
Huber LJ, Hempstead B, Donovan MJ. Neurotrophin and neurotrophin receptors in human fetal kidney. Developmental Biology. 179: 369-81. PMID 8903353 DOI: 10.1006/dbio.1996.0268 |
0.418 |
|
| 1996 |
Donovan MJ, Hahn R, Tessarollo L, Hempstead BL. Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nature Genetics. 14: 210-3. PMID 8841198 DOI: 10.1038/ng1096-210 |
0.435 |
|
| 1996 |
Melamed I, Kelleher CA, Franklin RA, Brodie C, Hempstead B, Kaplan D, Gelfand EW. Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk. European Journal of Immunology. 26: 1985-92. PMID 8814235 DOI: 10.1002/Eji.1830260903 |
0.379 |
|
| 1996 |
Lander HM, Milbank AJ, Tauras JM, Hajjar DP, Hempstead BL, Schwartz GD, Kraemer RT, Mirza UA, Chait BT, Burk SC, Quilliam LA. Redox regulation of cell signalling. Nature. 381: 380-1. PMID 8632794 DOI: 10.1038/381380A0 |
0.307 |
|
| 1995 |
Teng KK, Lander H, Fajardo JE, Hanafusa H, Hempstead BL, Birge RB. v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway. The Journal of Biological Chemistry. 270: 20677-85. PMID 7657647 DOI: 10.1074/jbc.270.35.20677 |
0.752 |
|
| 1995 |
Teng KK, Lander H, Fajardo JE, Hanafusa H, Hempstead BL, Birge RB.. 21. v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway. J Biol Chem. 270: 20677. PMID 7657647 |
0.736 |
|
| 1995 |
Muragaki Y, Timothy N, Leight S, Hempstead BL, Chao MV, Trojanowski JQ, Lee VM. Expression of trk receptors in the developing and adult human central and peripheral nervous system. The Journal of Comparative Neurology. 356: 387-97. PMID 7642800 DOI: 10.1002/Cne.903560306 |
0.607 |
|
| 1995 |
Chao MV, Hempstead BL. p75 and Trk: a two-receptor system. Trends in Neurosciences. 18: 321-6. PMID 7571013 DOI: 10.1016/0166-2236(95)93922-K |
0.63 |
|
| 1995 |
Pérez P, Coll PM, Hempstead BL, MartÃn-Zanca D, Chao MV. NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Molecular and Cellular Neurosciences. 6: 97-105. PMID 7551570 DOI: 10.1006/Mcne.1995.1010 |
0.581 |
|
| 1994 |
Mahadeo D, Kaplan L, Chao MV, Hempstead BL. High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors. The Journal of Biological Chemistry. 269: 6884-91. PMID 8120051 |
0.545 |
|
| 1994 |
Hempstead BL, Birge RB, Fajardo JE, Glassman R, Mahadeo D, Kraemer R, Hanafusa H. Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. Molecular and Cellular Biology. 14: 1964-71. PMID 7509449 DOI: 10.1128/Mcb.14.3.1964 |
0.418 |
|
| 1993 |
Hempstead BL. Strategies for modulating Trk receptor activity. Experimental Neurology. 124: 31-5. PMID 8282076 DOI: 10.1006/exnr.1993.1170 |
0.331 |
|
| 1993 |
Donovan MJ, Hempstead BL, Horvath C, Chao MV, Schofield D. Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors. The American Journal of Pathology. 143: 1560-7. PMID 8256848 |
0.44 |
|
| 1993 |
Horvath CM, Wolven A, Machadeo D, Huber J, Boter L, Benedetti M, Hempstead B, Chao MV. Analysis of the trk NGF receptor tyrosine kinase using recombinant fusion proteins. Journal of Cell Science. Supplement. 17: 223-8. PMID 8144701 DOI: 10.1242/Jcs.1993.Supplement_17.31 |
0.727 |
|
| 1992 |
Hempstead BL, Rabin SJ, Kaplan L, Reid S, Parada LF, Kaplan DR. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron. 9: 883-96. PMID 1384575 DOI: 10.1016/0896-6273(92)90241-5 |
0.41 |
|
| 1991 |
Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV. High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature. 350: 678-83. PMID 1850821 DOI: 10.1038/350678A0 |
0.593 |
|
| 1991 |
Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science (New York, N.Y.). 252: 554-8. PMID 1850549 DOI: 10.1126/Science.1850549 |
0.6 |
|
| 1991 |
Berg MM, Sternberg DW, Hempstead BL, Chao MV. The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 88: 7106-10. PMID 1714587 DOI: 10.1073/Pnas.88.16.7106 |
0.602 |
|
| 1990 |
Hempstead BL, Patil N, Thiel B, Chao MV. Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding. The Journal of Biological Chemistry. 265: 9595-8. PMID 2161836 |
0.535 |
|
| 1989 |
Hempstead B, Patil N, Olson K, Chao M. Molecular analysis of the nerve growth factor receptor. Cold Spring Harbor Symposia On Quantitative Biology. 477-85. PMID 2855487 DOI: 10.1101/Sqb.1988.053.01.055 |
0.542 |
|
| 1989 |
Hempstead BL, Chao MV. The nerve growth factor receptor: biochemical and structural analysis. Recent Progress in Hormone Research. 45: 441-63; discussion 4. PMID 2554433 DOI: 10.1016/B978-0-12-571145-6.50013-3 |
0.617 |
|
| 1989 |
Hempstead BL, Schleifer LS, Chao MV. Expression of functional nerve growth factor receptors after gene transfer. Science (New York, N.Y.). 243: 373-5. PMID 2536190 DOI: 10.1126/Science.2536190 |
0.593 |
|
| 1983 |
Hempstead BL, Parker CW, Kulczycki A. Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 3050-3. PMID 6190168 DOI: 10.1073/Pnas.80.10.3050 |
0.321 |
|
| 1981 |
Hempstead BL, Kulczycki A, Parker CW. Phosphorylation of the IgE receptor from ionophore A23187 stimulated intact rat mast cells. Biochemical and Biophysical Research Communications. 98: 815-22. PMID 6452878 DOI: 10.1016/0006-291X(81)91184-0 |
0.351 |
|
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