Barbara L. Hempstead - Publications

Weill Cornell Medical College, New York, NY, United States 
Hematology Oncology/Neurotrophins

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yang J, Ma Q, Dincheva I, Giza J, Jing D, Marinic T, Milner TA, Rajadhyaksha A, Lee FS, Hempstead BL. SorCS2 is required for social memory and trafficking of the NMDA receptor. Molecular Psychiatry. PMID 31988435 DOI: 10.1038/s41380-020-0650-7  1
2018 Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, Liston C, Jing D, Hempstead BL, Lee FS. The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 99: 1356. PMID 30236287 DOI: 10.1016/j.neuron.2018.08.041  1
2018 Lee FS, Hempstead BL. New Roles for an Ancient Factor. Trends in Neurosciences. PMID 30219601 DOI: 10.1016/j.tins.2018.08.012  1
2018 Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, Liston C, Jing D, Hempstead BL, Lee FS. The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. PMID 29909994 DOI: 10.1016/j.neuron.2018.05.024  1
2018 Greenwood SG, Montroull L, Volosin M, Scharfman HE, Teng KK, Light M, Torkin R, Maxfield F, Hempstead BL, Friedman WJ. A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo. Eneuro. 5. PMID 29349290 DOI: 10.1523/ENEURO.0257-17.2017  1
2017 Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, ... Hempstead BL, et al. Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29052614 DOI: 10.1038/npp.2017.252  0.32
2017 Ma Q, Yang J, Milner TA, Vonsattel JG, Palko ME, Tessarollo L, Hempstead BL. SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. Jci Insight. 2. PMID 28469074 DOI: 10.1172/jci.insight.88995  0.68
2016 Harward SC, Hedrick NG, Hall CE, Parra-Bueno P, Milner TA, Pan E, Laviv T, Hempstead BL, Yasuda R, McNamara JO. Autocrine BDNF-TrkB signalling within a single dendritic spine. Nature. PMID 27680698 DOI: 10.1038/nature19766  1
2015 Anastasia A, Barker PA, Chao MV, Hempstead BL. Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11911-20. PMID 26311773 DOI: 10.1523/JNEUROSCI.0591-15.2015  1
2015 Ma Q, Yang J, Li T, Milner TA, Hempstead BL. Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease. Neurobiology of Disease. 82: 466-477. PMID 26282324 DOI: 10.1016/j.nbd.2015.08.008  0.68
2015 Song M, Giza J, Proenca CC, Jing D, Elliott M, Dincheva I, Shmelkov SV, Kim J, Schreiner R, Huang SH, Castrén E, Prekeris R, Hempstead BL, Chao MV, Dictenberg JB, et al. Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Developmental Cell. 33: 690-702. PMID 26004511 DOI: 10.1016/j.devcel.2015.04.009  1
2015 Lee BG, Anastasia A, Hempstead BL, Lee FS, Blendy JA. Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 25744957 DOI: 10.1093/ntr/ntv047  1
2015 Ma Q, Yang J, Li T, Milner TA, Hempstead BL. Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease Neurobiology of Disease. 82: 466-477. DOI: 10.1016/j.nbd.2015.08.008  1
2015 DelNero P, Lane M, Verbridge SS, Kwee B, Kermani P, Hempstead B, Stroock A, Fischbach C. 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways Biomaterials. 55: 110-118. DOI: 10.1016/j.biomaterials.2015.03.035  1
2014 VonDran MW, LaFrancois J, Padow VA, Friedman WJ, Scharfman HE, Milner TA, Hempstead BL. p75NTR, but not proNGF, is upregulated following status epilepticus in mice. Asn Neuro. 6. PMID 25290065 DOI: 10.1177/1759091414552185  1
2014 Fulmer CG, VonDran MW, Stillman AA, Huang Y, Hempstead BL, Dreyfus CF. Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8186-96. PMID 24920623 DOI: 10.1523/JNEUROSCI.4267-13.2014  1
2014 Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q, Jing D, Lafrancois JJ, Bath KG, Mark W, Ballon D, Lee FS, Scharfman HE, Hempstead BL. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Reports. 7: 796-806. PMID 24746813 DOI: 10.1016/j.celrep.2014.03.040  1
2014 Hempstead BL. Deciphering proneurotrophin actions. Handbook of Experimental Pharmacology. 220: 17-32. PMID 24668468 DOI: 10.1007/978-3-642-45106-5_2  1
2014 Irmady K, Jackman KA, Padow VA, Shahani N, Martin LA, Cerchietti L, Unsicker K, Iadecola C, Hempstead BL. Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3419-28. PMID 24573298 DOI: 10.1523/JNEUROSCI.1982-13.2014  1
2014 Anastasia A, Deinhardt K, Wang S, Martin L, Nichol D, Irmady K, Trinh J, Parada L, Rafii S, Hempstead BL, Kermani P. Trkb signaling in pericytes is required for cardiac microvessel stabilization. Plos One. 9: e87406. PMID 24498100 DOI: 10.1371/journal.pone.0087406  1
2014 Anastasia A, Deinhardt K, Chao MV, Will NE, Irmady K, Lee FS, Hempstead BL, Bracken C. Corrigendum: Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction Nature Communications. 5. DOI: 10.1038/ncomms4564  1
2013 Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 155: 1596-609. PMID 24360280 DOI: 10.1016/j.cell.2013.11.030  1
2013 Anastasia A, Deinhardt K, Chao MV, Will NE, Irmady K, Lee FS, Hempstead BL, Bracken C. Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature Communications. 4: 2490. PMID 24048383 DOI: 10.1038/ncomms3490  1
2013 Takeda K, Kermani P, Anastasia A, Obinata Y, Hempstead BL, Kurihara H. BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 341-9. PMID 24032685 DOI: 10.1139/bcb-2013-0005  1
2013 Lorentz CU, Parrish DC, Alston EN, Pellegrino MJ, Woodward WR, Hempstead BL, Habecker BA. Sympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor. Experimental Neurology. 249: 111-9. PMID 24013014 DOI: 10.1016/j.expneurol.2013.08.015  1
2013 Morgan JP, Delnero PF, Zheng Y, Verbridge SS, Chen J, Craven M, Choi NW, Diaz-Santana A, Kermani P, Hempstead B, López JA, Corso TN, Fischbach C, Stroock AD. Formation of microvascular networks in vitro. Nature Protocols. 8: 1820-36. PMID 23989676 DOI: 10.1038/nprot.2013.110  1
2013 Je HS, Yang F, Ji Y, Potluri S, Fu XQ, Luo ZG, Nagappan G, Chan JP, Hempstead B, Son YJ, Lu B. ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9957-62. PMID 23761891 DOI: 10.1523/JNEUROSCI.0163-13.2013  1
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Hempstead BL, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/srep01449  1
2012 Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, ... Hempstead BL, et al. ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. The Journal of Experimental Medicine. 209: 2291-305. PMID 23091165 DOI: 10.1084/jem.20111749  1
2012 Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S. Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14080-6. PMID 23055476 DOI: 10.1523/JNEUROSCI.3359-12.2012  1
2012 Je HS, Yang F, Ji Y, Nagappan G, Hempstead BL, Lu B. Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proceedings of the National Academy of Sciences of the United States of America. 109: 15924-9. PMID 23019376 DOI: 10.1073/pnas.1207767109  1
2012 Zheng Y, Chen J, Craven M, Choi NW, Totorica S, Diaz-Santana A, Kermani P, Hempstead B, Fischbach-Teschl C, López JA, Stroock AD. In vitro microvessels for the study of angiogenesis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 9342-7. PMID 22645376 DOI: 10.1073/pnas.1201240109  1
2012 Kalous A, Nangle MR, Anastasia A, Hempstead BL, Keast JR. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. Journal of Neurochemistry. 122: 523-36. PMID 22621370 DOI: 10.1111/j.1471-4159.2012.07799.x  1
2012 Taylor AR, Gifondorwa DJ, Robinson MB, Strupe JL, Prevette D, Johnson JE, Hempstead B, Oppenheim RW, Milligan CE. Motoneuron programmed cell death in response to proBDNF. Developmental Neurobiology. 72: 699-712. PMID 21834083 DOI: 10.1002/dneu.20964  1
2011 Deinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA, Chao MV, Hempstead BL. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Science Signaling. 4: ra82. PMID 22155786 DOI: 10.1126/scisignal.2002060  1
2011 Evans SF, Irmady K, Ostrow K, Kim T, Nykjaer A, Saftig P, Blobel C, Hempstead BL. Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. The Journal of Biological Chemistry. 286: 29556-67. PMID 21730062 DOI: 10.1074/jbc.M111.219675  1
2011 Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6392-7. PMID 21525279 DOI: 10.1523/JNEUROSCI.6249-10.2011  1
2010 Song W, Volosin M, Cragnolini AB, Hempstead BL, Friedman WJ. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15608-15. PMID 21084616 DOI: 10.1523/JNEUROSCI.2581-10.2010  1
2010 Teng KK, Felice S, Kim T, Hempstead BL. Understanding proneurotrophin actions: Recent advances and challenges. Developmental Neurobiology. 70: 350-9. PMID 20186707 DOI: 10.1002/dneu.20768  1
2010 Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC. Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Journal of Molecular Biology. 396: 967-84. PMID 20036257 DOI: 10.1016/j.jmb.2009.12.030  1
2009 Greenberg ME, Xu B, Lu B, Hempstead BL. New insights in the biology of BDNF synthesis and release: implications in CNS function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12764-7. PMID 19828787 DOI: 10.1523/JNEUROSCI.3566-09.2009  1
2009 Hempstead BL. Commentary: Regulating proNGF action: multiple targets for therapeutic intervention. Neurotoxicity Research. 16: 255-60. PMID 19526280 DOI: 10.1007/s12640-009-9054-9  1
2009 Yang F, Je HS, Ji Y, Nagappan G, Hempstead B, Lu B. Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses. The Journal of Cell Biology. 185: 727-41. PMID 19451278 DOI: 10.1083/jcb.200811147  1
2009 Kim T, Hempstead BL. NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. The Embo Journal. 28: 1612-23. PMID 19407813 DOI: 10.1038/emboj.2009.118  1
2009 Casey BJ, Glatt CE, Tottenham N, Soliman F, Bath K, Amso D, Altemus M, Pattwell S, Jones R, Levita L, McEwen B, Magariños AM, Gunnar M, Thomas KM, Mezey J, ... ... Hempstead BL, et al. Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience. 164: 108-20. PMID 19358879 DOI: 10.1016/j.neuroscience.2009.03.081  1
2009 Bath KG, Voss HU, Jing D, Anderson S, Hempstead B, Lee FS, Dyke JP, Ballon DJ. Quantitative intact specimen magnetic resonance microscopy at 3.0 T. Magnetic Resonance Imaging. 27: 672-80. PMID 19152774 DOI: 10.1016/j.mri.2008.11.008  1
2009 Nagappan G, Zaitsev E, Senatorov VV, Yang J, Hempstead BL, Lu B. Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 106: 1267-72. PMID 19147841 DOI: 10.1073/pnas.0807322106  1
2009 Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, Lu B, Hempstead BL. Neuronal release of proBDNF. Nature Neuroscience. 12: 113-5. PMID 19136973 DOI: 10.1038/nn.2244  1
2008 Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, Carter BD, Friedman WJ. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9870-9. PMID 18815271 DOI: 10.1523/JNEUROSCI.2841-08.2008  1
2008 Chen ZY, Bath K, McEwen B, Hempstead B, Lee F. Impact of genetic variant BDNF (Val66Met) on brain structure and function. Novartis Foundation Symposium. 289: 180-8; discussion 18. PMID 18497103  1
2008 Bath KG, Mandairon N, Jing D, Rajagopal R, Kapoor R, Chen ZY, Khan T, Proenca CC, Kraemer R, Cleland TA, Hempstead BL, Chao MV, Lee FS. Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2383-93. PMID 18322085 DOI: 10.1523/JNEUROSCI.4387-07.2008  1
2008 Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C. Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. The Journal of Investigative Dermatology. 128: 2031-40. PMID 18305571 DOI: 10.1038/jid.2008.21  1
2007 Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience. 10: 1449-57. PMID 17934455 DOI: 10.1038/nn2000  1
2007 Johnston AL, Lun X, Rahn JJ, Liacini A, Wang L, Hamilton MG, Parney IF, Hempstead BL, Robbins SM, Forsyth PA, Senger DL. The p75 neurotrophin receptor is a central regulator of glioma invasion. Plos Biology. 5: e212. PMID 17696644 DOI: 10.1371/journal.pbio.0050212  1
2007 Kermani P, Hempstead B. Brain-Derived Neurotrophic Factor: A Newly Described Mediator of Angiogenesis Trends in Cardiovascular Medicine. 17: 140-143. PMID 17482097 DOI: 10.1016/j.tcm.2007.03.002  1
2007 Domeniconi M, Hempstead BL, Chao MV. Pro-NGF secreted by astrocytes promotes motor neuron cell death. Molecular and Cellular Neurosciences. 34: 271-9. PMID 17188890 DOI: 10.1016/j.mcn.2006.11.005  1
2006 Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (New York, N.Y.). 314: 140-3. PMID 17023662 DOI: 10.1126/science.1129663  1
2006 Ruan J, Hyjek E, Kermani P, Christos PJ, Hooper AT, Coleman M, Hempstead B, Leonard JP, Chadburn A, Rafii S. Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma Clinical Cancer Research. 12: 5622-5631. PMID 17020964 DOI: 10.1158/1078-0432.CCR-06-1204  1
2006 Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL. TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Developmental Biology. 299: 455-65. PMID 17005175 DOI: 10.1016/j.ydbio.2006.08.025  1
2006 Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7756-66. PMID 16855103 DOI: 10.1523/JNEUROSCI.1560-06.2006  1
2006 Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM. Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5288-300. PMID 16707781 DOI: 10.1523/JNEUROSCI.3547-05.2006  1
2006 Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 50: 219-32. PMID 16630834 DOI: 10.1016/j.neuron.2006.03.011  1
2006 Hempstead BL. Dissecting the diverse actions of pro- and mature neurotrophins. Current Alzheimer Research. 3: 19-24. PMID 16472198 DOI: 10.2174/156720506775697061  1
2005 Kraemer R, Baker PJ, Kent KC, Ye Y, Han JJ, Tejada R, Silane M, Upmacis R, Deeb R, Chen Y, Levine DM, Hempstead B. Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. Circulation. 112: 3644-53. PMID 16330706 DOI: 10.1161/CIRCULATIONAHA.105.587980  1
2005 Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience. 8: 1069-77. PMID 16025106 DOI: 10.1038/nn1510  1
2005 Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, Nykjaer A, Hempstead BL, Lee FS. Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6156-66. PMID 15987945 DOI: 10.1523/JNEUROSCI.1017-05.2005  1
2005 Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, Kraemer RT, Nykjaer A, Hempstead BL. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5455-63. PMID 15930396 DOI: 10.1523/JNEUROSCI.5123-04.2005  1
2005 Zhang F, Cheng J, Lam G, Jin DK, Vincent L, Hackett NR, Wang S, Young LM, Hempstead B, Crystal RG, Rafii S. Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. Circulation Research. 96: 950-7. PMID 15831817 DOI: 10.1161/01.RES.0000165867.95291.7b  1
2005 Hempstead BL. Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 5645-6. PMID 15827113 DOI: 10.1073/pnas.0501718102  1
2005 Kermani P, Rafii D, Jin DK, Whitlock P, Schaffer W, Chiang A, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Rafii S, Hempstead BL. Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. The Journal of Clinical Investigation. 115: 653-63. PMID 15765148 DOI: 10.1172/JCI22655  1
2005 Shmelkov SV, Meeus S, Moussazadeh N, Kermani P, Rashbaum WK, Rabbany SY, Hanson MA, Lane WJ, St Clair R, Walsh KA, Dias S, Jacobson JT, Hempstead BL, Edelberg JM, Rafii S. Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue. Circulation. 111: 1175-83. PMID 15753226 DOI: 10.1161/01.CIR.0000157155.44008.0F  1
2005 Klein M, Hempstead BL, Teng KK. Activation of STAT5-dependent transcription by the neurotrophin receptor Trk. Journal of Neurobiology. 63: 159-71. PMID 15702476 DOI: 10.1002/neu.20124  1
2005 Pedraza CE, Podlesniy P, Vidal N, Arévalo JC, Lee R, Hempstead B, Ferrer I, Iglesias M, Espinet C. Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. The American Journal of Pathology. 166: 533-43. PMID 15681836 DOI: 10.1016/S0002-9440(10)62275-4  1
2005 Linggi MS, Burke TL, Williams BB, Harrington A, Kraemer R, Hempstead BL, Yoon SO, Carter BD. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. The Journal of Biological Chemistry. 280: 13801-8. PMID 15668238 DOI: 10.1074/jbc.M410435200  1
2005 Pearse RN, Swendeman SL, Li Y, Rafii D, Hempstead BL. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 105: 4429-36. PMID 15657181 DOI: 10.1182/blood-2004-08-3096  1
2004 Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, Teng KK, Yung WH, Hempstead BL, Lu B. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (New York, N.Y.). 306: 487-91. PMID 15486301 DOI: 10.1126/science.1100135  1
2004 Srinivasan B, Roque CH, Hempstead BL, Al-Ubaidi MR, Roque RS. Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor. The Journal of Biological Chemistry. 279: 41839-45. PMID 15277529 DOI: 10.1074/jbc.M402872200  1
2004 Kim H, Li Q, Hempstead BL, Madri JA. Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. The Journal of Biological Chemistry. 279: 33538-46. PMID 15169782 DOI: 10.1074/jbc.M404115200  1
2004 Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4401-11. PMID 15128854 DOI: 10.1523/JNEUROSCI.0348-04.2004  1
2004 Hempstead BL. Sculpting organ innervation. The Journal of Clinical Investigation. 113: 811-3. PMID 15067313 DOI: 10.1172/JCI21309  1
2004 Murray SS, Perez P, Lee R, Hempstead BL, Chao MV. A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2742-9. PMID 15028767 DOI: 10.1523/JNEUROSCI.3960-03.2004  1
2004 Harrington AW, Leiner B, Blechschmitt C, Arevalo JC, Lee R, Mörl K, Meyer M, Hempstead BL, Yoon SO, Giehl KM. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proceedings of the National Academy of Sciences of the United States of America. 101: 6226-30. PMID 15026568 DOI: 10.1073/pnas.0305755101  1
2004 Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 427: 843-8. PMID 14985763 DOI: 10.1038/nature02319  1
2004 Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological systems. Cellular and Molecular Life Sciences : Cmls. 61: 35-48. PMID 14704852 DOI: 10.1007/s00018-003-3099-3  1
2004 Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. The Journal of Clinical Investigation. 113: 38-48. PMID 14702107 DOI: 10.1172/JCI19684  1
2004 Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP. Essential role for ADAM19 in cardiovascular morphogenesis. Molecular and Cellular Biology. 24: 96-104. PMID 14673146 DOI: 10.1128/MCB.24.1.96-104.2004  1
2003 Kraemer R, Hempstead BL. Neurotrophins: novel mediators of angiogenesis. Frontiers in Bioscience : a Journal and Virtual Library. 8: s1181-6. PMID 12957860  1
2003 Shonukan T, Bagayogo I, McCrea PD, Chao M, Hempstead B. Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin Oncogene. 22: 3616-3623. PMID 12789270 DOI: 10.1038/sj.onc.1206561  1
2002 Hempstead BL, Salzer JL. Neurobiology. A glial spin on neurotrophins. Science (New York, N.Y.). 298: 1184-6. PMID 12424359 DOI: 10.1126/science.1078709  1
2002 Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 36: 375-86. PMID 12408842 DOI: 10.1016/S0896-6273(02)01005-X  1
2002 Hempstead BL. The many faces of p75NTR. Current Opinion in Neurobiology. 12: 260-7. PMID 12049931 DOI: 10.1016/S0959-4388(02)00321-5  1
2002 Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT. Erythropoietin receptor signalling is required for normal brain development. Development (Cambridge, England). 129: 505-16. PMID 11807041  1
2001 Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science (New York, N.Y.). 294: 1945-8. PMID 11729324 DOI: 10.1126/science.1065057  1
2001 Esposito D, Patel P, Stephens RM, Perez P, Chao MV, Kaplan DR, Hempstead BL. The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor. The Journal of Biological Chemistry. 276: 32687-95. PMID 11435417 DOI: 10.1074/jbc.M011674200  1
2000 Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development (Cambridge, England). 127: 4531-40. PMID 11023857  1
2000 Lin MI, Das I, Schwartz GM, Tsoulfas P, Mikawa T, Hempstead BL. Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. Developmental Biology. 226: 180-91. PMID 11023679 DOI: 10.1006/dbio.2000.9850  1
2000 Wang S, Bray P, McCaffrey T, March K, Hempstead BL, Kraemer R. p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells. The American Journal of Pathology. 157: 1247-58. PMID 11021829 DOI: 10.1016/S0002-9440(10)64640-8  1
2000 Arevalo JC, Conde B, Hempstead BL, Chao MV, Martin-Zanca D, Perez P. TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor. Molecular and Cellular Biology. 20: 5908-16. PMID 10913174 DOI: 10.1128/MCB.20.16.5908-5916.2000  1
2000 Escalante M, Courtney J, Chin WG, Teng KK, Kim JI, Fajardo JE, Mayer BJ, Hempstead BL, Birge RB. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. The Journal of Biological Chemistry. 275: 24787-97. PMID 10825157 DOI: 10.1074/jbc.M000711200  1
2000 Das I, Sparrow JR, Lin MI, Shih E, Mikawa T, Hempstead BL. Trk C signaling is required for retinal progenitor cell proliferation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2887-95. PMID 10751441  1
1999 Teng KK, Esposito DK, Schwartz GD, Lander HM, Hempstead BL. Activation of c-Ha-Ras by nitric oxide modulates survival responsiveness in neuronal PC12 cells. The Journal of Biological Chemistry. 274: 37315-20. PMID 10601298 DOI: 10.1074/jbc.274.52.37315  1
1999 Kraemer R, Nguyen H, March KL, Hempstead B. NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1041-1050. PMID 10195934  1
1998 Tessarollo L, Hempstead BL. Regulation of cardiac development by receptor tyrosine kinases. Trends in Cardiovascular Medicine. 8: 34-40. PMID 21235910 DOI: 10.1016/S1050-1738(97)00119-9  1
1997 Glassman RH, Hempstead BL, Staiano-Coico L, Steiner MG, Hanafusa H, Birge RB. v-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells. Cell Death and Differentiation. 4: 82-93. PMID 16465214 DOI: 10.1038/sj.cdd.4400203  1
1997 Tessarollo L, Tsoulfas P, Donovan MJ, Palko ME, Blair-Flynn J, Hempstead BL, Parada LF. Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 94: 14776-81. PMID 9405689 DOI: 10.1073/pnas.94.26.14776  1
1997 Das I, Hempstead BL, MacLeish PR, Sparrow JR. Immunohistochemical analysis of the neurotrophins BDNF and NT-3 and their receptors trk B, trk C, and p75 in the developing chick retina. Visual Neuroscience. 14: 835-42. PMID 9364722  1
1997 Hempstead BL, Chao MV. Entering the domain of neurotrophin binding. Nature Biotechnology. 15: 623-4. PMID 9219261 DOI: 10.1038/nbt0797-623  1
1997 Lander HM, Hajjar DP, Hempstead BL, Mirza UA, Chait BT, Campbell S, Quilliam LA. A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. The Journal of Biological Chemistry. 272: 4323-6. PMID 9020151 DOI: 10.1074/jbc.272.7.4323  1
1996 Teng KK, Courtney JC, Henegouwen PB, Birge RB, Hempstead BL. Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells Molecular and Cellular Neurosciences. 8: 157-70. PMID 8954630 DOI: 10.1006/mcne.1996.0054  1
1996 Teng KK, Courtney JC, van Bergen en Henegouwen P, Birge RB, Hempstead BL. Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-Crk in PC12 cells. Molecular and Cellular Neurosciences. 8: 157-70. PMID 8918832  1
1996 Donovan MJ, Hahn R, Tessarollo L, Hempstead BL. Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nature Genetics. 14: 210-3. PMID 8841198 DOI: 10.1038/ng1096-210  1
1996 Lander HM, Milbank AJ, Tauras JM, Hajjar DP, Hempstead BL, Schwartz GD, Kraemer RT, Mirza UA, Chait BT, Burk SC, Quilliam LA. Redox regulation of cell signalling. Nature. 381: 380-1. PMID 8632794 DOI: 10.1038/381380a0  1
1996 Teig KK, Courtney JC, Birgr RB, Hempstead BL. Dissociation of ngf induced signal transduction from neurite out-growth by expression of a mutant adaptor protein in pc12 cells Journal of Investigative Medicine. 44: 241a.  1
1996 Das I, MacLeish PR, Hempstead BL, Sparrow JR. Immunohistochemical analysis of trk C and P75 expression in the developing chick retina Investigative Ophthalmology and Visual Science. 37: S1051.  1
1995 Teng KK, Lander H, Fajardo JE, Hanafusa H, Hempstead BL, Birge RB. v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway. The Journal of Biological Chemistry. 270: 20677-85. PMID 7657647 DOI: 10.1074/jbc.270.35.20677  1
1995 Muragaki Y, Timothy N, Leight S, Hempstead BL, Chao MV, Trojanowski JQ, Lee VM. Expression of trk receptors in the developing and adult human central and peripheral nervous system. The Journal of Comparative Neurology. 356: 387-97. PMID 7642800 DOI: 10.1002/cne.903560306  1
1995 Donovan MJ, Miranda RC, Kraemer R, McCaffrey TA, Tessarollo L, Mahadeo D, Sharif S, Kaplan DR, Tsoulfas P, Parada L. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. The American Journal of Pathology. 147: 309-24. PMID 7639328  1
1995 Chao MV, Hempstead BL. p75 and Trk: a two-receptor system. Trends in Neurosciences. 18: 321-6. PMID 7571013 DOI: 10.1016/0166-2236(95)93922-K  1
1995 Pérez P, Coll PM, Hempstead BL, Martín-Zanca D, Chao MV. NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Molecular and Cellular Neurosciences. 6: 97-105. PMID 7551570 DOI: 10.1006/mcne.1995.1010  1
1994 Mahadeo D, Kaplan L, Chao MV, Hempstead BL. High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors. The Journal of Biological Chemistry. 269: 6884-91. PMID 8120051  1
1994 Hempstead BL, Birge RB, Fajardo JE, Glassman R, Mahadeo D, Kraemer R, Hanafusa H. Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. Molecular and Cellular Biology. 14: 1964-71. PMID 7509449  1
1993 Hempstead BL. Strategies for modulating Trk receptor activity. Experimental Neurology. 124: 31-5. PMID 8282076 DOI: 10.1006/exnr.1993.1170  1
1993 Donovan MJ, Hempstead BL, Horvath C, Chao MV, Schofield D. Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors. The American Journal of Pathology. 143: 1560-7. PMID 8256848  1
1992 Hempstead BL, Rabin SJ, Kaplan L, Reid S, Parada LF, Kaplan DR. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron. 9: 883-96. PMID 1384575 DOI: 10.1016/0896-6273(92)90241-5  1
1991 Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV. High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature. 350: 678-83. PMID 1850821 DOI: 10.1038/350678a0  1
1991 Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science (New York, N.Y.). 252: 554-8. PMID 1850549  1
1991 Pedraza L, Frey AB, Hempstead BL, Colman DR, Salzer JL. Differential expression of MAG isoforms during development. Journal of Neuroscience Research. 29: 141-8. PMID 1716323 DOI: 10.1002/jnr.490290202  1
1991 Berg MM, Sternberg DW, Hempstead BL, Chao MV. The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 88: 7106-10. PMID 1714587  1
1990 Hempstead BL, Patil N, Thiel B, Chao MV. Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding. The Journal of Biological Chemistry. 265: 9595-8. PMID 2161836  1
1989 Hempstead BL, Chao MV. The nerve growth factor receptor: biochemical and structural analysis. Recent Progress in Hormone Research. 45: 441-63; discussion 4. PMID 2554433  1
1989 Hempstead BL, Schleifer LS, Chao MV. Expression of functional nerve growth factor receptors after gene transfer. Science (New York, N.Y.). 243: 373-5. PMID 2536190  1
1983 Hempstead BL, Parker CW, Kulczycki A. Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 3050-3. PMID 6190168  1
1981 Hempstead BL, Parker CW, Kulczycki A. The cell surface receptor for immunoglobulin E. Effect of tunicamycin on molecular properties of receptor from rat basophilic leukemia cells. The Journal of Biological Chemistry. 256: 10717-23. PMID 6457041  1
1981 Hempstead BL, Kulczycki A, Parker CW. Phosphorylation of the IgE receptor from ionophore A23187 stimulated intact rat mast cells. Biochemical and Biophysical Research Communications. 98: 815-22. PMID 6452878 DOI: 10.1016/0006-291X(81)91184-0  1
1981 Hempstead BL, Parker CW, Kulczycki A. Effect of tunicamycin on the molecular properties of the IgE receptor Federation Proceedings. 40: 731.  1
1979 Hempstead BL, Parker CW, Kulczycki A. Characterization of the IgE receptor isolated from human basophils. Journal of Immunology (Baltimore, Md. : 1950). 123: 2283-91. PMID 489984  1
1979 Kulczycki A, Hempstead BL, Hofmann SL, Wood EW, Parker CW. The cell surface receptor for immunoglobulin E. II. Properties of the purified biologically active receptor. The Journal of Biological Chemistry. 254: 3194-200. PMID 429344  1
1978 Kulczycki A, Hempstead BL, Hofmann SL. Purification of biologically-active IgE receptor Clinical Research. 26: 517A.  1
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