Horace H. Loh - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Opioid pharmacology
Website:
http://www.pharmacology.med.umn.edu/staffloh.html

332 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hsu YT, Chen SR, Chang YC, Chang HF, Yeh TK, Chuang JY, Loh HH, Hsieh HP, Ueng SH, Yeh SH. A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects. European Journal of Medicinal Chemistry. 258: 115608. PMID 37437352 DOI: 10.1016/j.ejmech.2023.115608  0.342
2022 Kuppusamy R, Hsu YT, Ke YY, Chang PW, Chang YC, Chang HF, Wang PC, Lin YH, Huang YC, Yeh TK, Chuang JY, Loh HH, Shih C, Chen CT, Yeh SH, et al. Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation. European Journal of Medicinal Chemistry. 243: 114728. PMID 36084534 DOI: 10.1016/j.ejmech.2022.114728  0.338
2020 Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Reports. 30: 3625-3631.e6. PMID 32187535 DOI: 10.1016/J.Celrep.2020.02.075  0.39
2020 Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, et al. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32154623 DOI: 10.1096/Fj.201902873R  0.38
2020 Huang YH, Wu YW, Chuang JY, Chang YC, Chang HF, Tao PL, Loh HH, Yeh SH. Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu opioid receptor splice variants. Pain. PMID 32040076 DOI: 10.1097/j.pain.0000000000001823  0.317
2020 Huang Y, Yeh S, Loh HH, Chuang J. Pharmacological studies of morphine in a novel humanized mu opioid receptor mouse model The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.02835  0.369
2019 Chao PK, Chang HF, Chang WT, Yeh TK, Ou LC, Chuang JY, Tsu-An Hsu J, Tao PL, Loh HH, Shih C, Ueng SH, Yeh SH. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology. 107678. PMID 31278929 DOI: 10.1016/j.neuropharm.2019.107678  0.397
2019 Yang PP, Yeh TK, Loh HH, Law PY, Wang Y, Tao PL. Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice. European Journal of Pharmacology. PMID 30959048 DOI: 10.1016/J.Ejphar.2019.04.009  0.336
2019 Chao PK, Chang HF, Ou LC, Chuang JY, Lee PT, Chang WT, Chen SC, Ueng SH, Hsu JT, Tao PL, Law PY, Loh HH, Yeh SH. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Scientific Reports. 9: 2405. PMID 30787373 DOI: 10.1038/s41598-019-39555-x  0.409
2019 Lin SY, Kuo YH, Tien YW, Ke YY, Chang WT, Chang HF, Ou LC, Law PY, Xi JH, Tao PL, Loh HH, Chao YS, Shih C, Chen CT, Yeh SH, et al. The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone. European Journal of Medicinal Chemistry. 167: 312-323. PMID 30776693 DOI: 10.1016/j.ejmech.2019.01.063  0.321
2017 Zhang L, Kibaly C, Wang YJ, Xu C, Song KY, W McGarrah P, Loh HH, Liu JG, Law PY. Src-dependent phosphorylation of μ-opioid receptor at Tyr(336) modulates opiate withdrawal. Embo Molecular Medicine. PMID 28818835 DOI: 10.15252/emmm.201607324  0.324
2017 Chao PK, Ueng SH, Ou LC, Yeh TK, Chang WT, Chang HF, Chen SC, Tao PL, Law PY, Loh HH, Cheng MF, Chuang JY, Chen CT, Shih C, Yeh SH. 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine. Anesthesiology. PMID 28212204 DOI: 10.1097/ALN.0000000000001568  0.333
2017 Kibaly C, Lin HY, Loh HH, Law PY. Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo. Pharmacological Research. PMID 28179123 DOI: 10.1016/j.phrs.2017.01.033  0.362
2016 Ke YY, Huang YH, Chien WC, Loh HH, Chuang JY, Yeh SH. Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers. Biochimica Et Biophysica Acta. PMID 28012872 DOI: 10.1016/j.bbapap.2016.12.010  0.345
2016 Chen SR, Ke YY, Yeh TK, Lin SY, Ou LC, Chen SC, Chang WT, Chang HF, Wu ZH, Hsieh CC, Law PY, Loh HH, Shih C, Lai YK, Yeh SH, et al. Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists. European Journal of Medicinal Chemistry. 126: 202-217. PMID 27776274 DOI: 10.1016/j.ejmech.2016.09.003  0.332
2016 Yang PP, Yeh GC, Yeh TK, Xi J, Loh HH, Law PY, Tao PL. Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice. Pharmacological Research. PMID 27496654 DOI: 10.1016/j.phrs.2016.05.034  0.4
2016 Song KY, Choi HS, Law PY, Wei LN, Loh HH. Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1. Journal of Cellular Physiology. PMID 27292014 DOI: 10.1002/jcp.25455  0.33
2015 Wang Y, Ge YH, Wang YX, Liu T, Law PY, Loh HH, Chen HZ, Qiu Y. Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12. Cns Neuroscience & Therapeutics. 21: 591-8. PMID 26096047 DOI: 10.1111/Cns.12409  0.318
2015 Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH. Analysis of epigenetic mechanisms regulating opioid receptor gene transcription. Methods in Molecular Biology (Clifton, N.J.). 1230: 39-51. PMID 25293314 DOI: 10.1007/978-1-4939-1708-2_3  0.319
2015 Kao JH, Gao MJ, Yang PP, Law PY, Loh HH, Tao PL. Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord. British Journal of Pharmacology. 172: 630-41. PMID 24866991 DOI: 10.1111/bph.12790  0.328
2014 Lee PT, Chao PK, Ou LC, Chuang JY, Lin YC, Chen SC, Chang HF, Law PY, Loh HH, Chao YS, Su TP, Yeh SH. Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling. Nucleic Acids Research. 42: 13012-25. PMID 25361975 DOI: 10.1093/nar/gku1016  0.322
2014 Cheng MF, Ou LC, Chen SC, Chang WT, Law PY, Loh HH, Chao YS, Shih C, Yeh SH, Ueng SH. Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists. Bioorganic & Medicinal Chemistry. 22: 4694-703. PMID 25087049 DOI: 10.1016/J.Bmc.2014.07.012  0.348
2014 Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H. Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms. Biological Psychiatry. 76: 775-84. PMID 24993058 DOI: 10.1016/j.biopsych.2014.05.013  0.322
2014 Yan YH, Wang Y, Zhao LX, Jiang S, Loh HH, Law PY, Chen HZ, Qiu Y. Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization. Neuroscience Letters. 566: 231-5. PMID 24607931 DOI: 10.1016/J.Neulet.2014.02.059  0.337
2013 Law PY, Reggio PH, Loh HH. Opioid receptors: toward separation of analgesic from undesirable effects. Trends in Biochemical Sciences. 38: 275-82. PMID 23598157 DOI: 10.1016/J.Tibs.2013.03.003  0.333
2013 Song KY, Choi HS, Law PY, Wei LN, Loh HH. Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation. Rna Biology. 10: 256-66. PMID 23353576 DOI: 10.4161/rna.23022  0.353
2013 Zheng H, Zhang Y, Li W, Loh HH, Law PY. NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 770-7. PMID 23303051 DOI: 10.1038/npp.2012.242  0.336
2013 Wu Q, Hwang CK, Zheng H, Wagley Y, Lin HY, Kim do K, Law PY, Loh HH, Wei LN. MicroRNA 339 down-regulates μ-opioid receptor at the post-transcriptional level in response to opioid treatment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 522-35. PMID 23085997 DOI: 10.1096/Fj.12-213439  0.725
2012 Miller EC, Zhang L, Dummer BW, Cariveau DR, Loh H, Law PY, Liao D. Differential modulation of drug-induced structural and functional plasticity of dendritic spines. Molecular Pharmacology. 82: 333-43. PMID 22596350 DOI: 10.1124/Mol.112.078162  0.412
2012 Chou SH, Kao JH, Tao PL, Law PY, Loh HH. Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway. Synapse (New York, N.Y.). 66: 694-704. PMID 22407757 DOI: 10.1002/syn.21555  0.311
2012 Lin HY, Law PY, Loh HH. Activation of protein kinase C (PKC)α or PKCε as an approach to increase morphine tolerance in respiratory depression and lethal overdose. The Journal of Pharmacology and Experimental Therapeutics. 341: 115-25. PMID 22228806 DOI: 10.1124/jpet.111.188235  0.321
2011 Liu XY, Liu ZC, Sun YG, Ross M, Kim S, Tsai FF, Li QF, Jeffry J, Kim JY, Loh HH, Chen ZF. Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Cell. 147: 447-58. PMID 22000021 DOI: 10.1016/j.cell.2011.08.043  0.386
2011 Kim do K, Hwang CK, Wagley Y, Law PY, Wei LN, Loh HH. p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide. Journal of Neurochemistry. 116: 1077-87. PMID 21198637 DOI: 10.1111/J.1471-4159.2010.07163.X  0.341
2011 Wei LN, Loh HH. Transcriptional and epigenetic regulation of opioid receptor genes: present and future. Annual Review of Pharmacology and Toxicology. 51: 75-97. PMID 20868272 DOI: 10.1146/Annurev-Pharmtox-010510-100605  0.302
2010 Kam AY, Liao D, Loh HH, Law PY. Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15304-16. PMID 21068335 DOI: 10.1523/Jneurosci.4255-10.2010  0.548
2010 Sanchez-Simon FM, Zhang XX, Loh HH, Law PY, Rodriguez RE. Morphine regulates dopaminergic neuron differentiation via miR-133b. Molecular Pharmacology. 78: 935-42. PMID 20716624 DOI: 10.1124/Mol.110.066837  0.3
2010 Kao JH, Chen SL, Ma HI, Law PY, Tao PL, Loh HH. Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm. The Journal of Pharmacology and Experimental Therapeutics. 334: 739-45. PMID 20554907 DOI: 10.1124/Jpet.109.165399  0.338
2010 Zheng H, Zeng Y, Chu J, Kam AY, Loh HH, Law PY. Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8102-10. PMID 20554861 DOI: 10.1523/Jneurosci.6069-09.2010  0.348
2010 Chen SL, Ma HI, Han JM, Lu RB, Tao PL, Law PY, Loh HH. Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene. Journal of Biomedical Science. 17: 28. PMID 20403204 DOI: 10.1186/1423-0127-17-28  0.375
2010 Chen YL, Monteith N, Law PY, Loh HH. Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation. Biochemical and Biophysical Research Communications. 396: 294-8. PMID 20399742 DOI: 10.1016/J.Bbrc.2010.04.083  0.467
2010 Chu J, Zheng H, Zhang Y, Loh HH, Law PY. Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cellular Signalling. 22: 684-96. PMID 20043990 DOI: 10.1016/J.Cellsig.2009.12.003  0.37
2010 Tao PL, Law PY, Loh HH. Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor. Iubmb Life. 62: 103-11. PMID 20039371 DOI: 10.1002/iub.292  0.326
2009 Song KY, Choi HS, Hwang CK, Kim CS, Law PY, Wei LN, Loh HH. Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1). Cellular and Molecular Life Sciences : Cmls. 66: 2933-42. PMID 19609488 DOI: 10.1007/s00018-009-0082-7  0.316
2009 Lin H, Higgins P, Loh HH, Law PY, Liao D. Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2097-111. PMID 19295508 DOI: 10.1038/Npp.2009.34  0.628
2009 Wu Q, Zhang L, Law PY, Wei LN, Loh HH. Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b. Molecular Pharmacology. 75: 744-50. PMID 19144786 DOI: 10.1124/Mol.108.053462  0.763
2008 Wu Q, Law PY, Wei LN, Loh HH. Post-transcriptional regulation of mouse mu opioid receptor (MOR1) via its 3' untranslated region: a role for microRNA23b. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4085-95. PMID 18716031 DOI: 10.1096/Fj.08-108175  0.734
2008 Zheng H, Chu J, Qiu Y, Loh HH, Law PY. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proceedings of the National Academy of Sciences of the United States of America. 105: 9421-6. PMID 18599439 DOI: 10.1073/Pnas.0802253105  0.3
2008 Chu J, Zheng H, Loh HH, Law PY. Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cellular Signalling. 20: 1616-24. PMID 18558479 DOI: 10.1016/J.Cellsig.2008.05.004  0.359
2008 Chen YL, Law PY, Loh HH. The other side of the opioid story: modulation of cell growth and survival signaling. Current Medicinal Chemistry. 15: 772-8. PMID 18393846 DOI: 10.2174/092986708783955518  0.564
2008 Chen YL, Law PY, Loh HH. NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression. Biochemical and Biophysical Research Communications. 368: 755-60. PMID 18269915 DOI: 10.1016/J.Bbrc.2008.01.164  0.464
2007 Chen SL, Ma HI, Han JM, Tao PL, Law PY, Loh HH. dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm. Proceedings of the National Academy of Sciences of the United States of America. 104: 20096-101. PMID 18056815 DOI: 10.1073/Pnas.0703409104  0.329
2007 Liao D, Grigoriants OO, Wang W, Wiens K, Loh HH, Law PY. Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors. Molecular and Cellular Neurosciences. 35: 456-69. PMID 17513124 DOI: 10.1016/J.Mcn.2007.04.007  0.575
2007 Chen YL, Law PY, Loh HH. Action of NF-kappaB on the delta opioid receptor gene promoter. Biochemical and Biophysical Research Communications. 352: 818-22. PMID 17150179 DOI: 10.1016/J.Bbrc.2006.11.103  0.479
2007 Tien LT, Ho IK, Loh HH, Ma T. Role of mu-opioid receptor in modulation of preproenkephalin mRNA expression and opioid and dopamine receptor binding in methamphetamine-sensitized mice. Journal of Neuroscience Research. 85: 673-80. PMID 17139685 DOI: 10.1002/Jnr.21145  0.331
2007 Liao D, Grigoriants OO, Loh HH, Law PY. Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons. Journal of Neurophysiology. 97: 1485-94. PMID 17122315 DOI: 10.1152/Jn.00790.2006  0.533
2006 Chen YL, Law PY, Loh HH. Nuclear factor kappaB signaling in opioid functions and receptor gene expression. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 270-9. PMID 18040804 DOI: 10.1007/S11481-006-9028-0  0.539
2006 Choi HS, Kim CS, Hwang CK, Song KY, Wang W, Qiu Y, Law PY, Wei LN, Loh HH. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochemical and Biophysical Research Communications. 343: 1132-40. PMID 16580639 DOI: 10.1016/j.bbrc.2006.03.084  0.345
2006 Zhao H, Loh HH, Law PY. Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization. Molecular Pharmacology. 69: 1421-32. PMID 16415176 DOI: 10.1124/Mol.105.020024  0.344
2006 Chen YL, Law PY, Loh HH. Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression. The Journal of Biological Chemistry. 281: 3067-74. PMID 16316997 DOI: 10.1074/jbc.M506721200  0.484
2005 Chen YL, Law PY, Loh HH. Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy. Current Medicinal Chemistry. Anti-Cancer Agents. 5: 575-89. PMID 16305480 DOI: 10.2174/156801105774574649  0.38
2005 Yoo JH, Cho JH, Lee SY, Loh HH, Ho IK, Jang CG. A lack of mu-opioid receptors modulates the expressions of neuropeptide Y and substance P mRNA. Neuroscience Letters. 384: 29-32. PMID 15885902 DOI: 10.1016/J.Neulet.2005.04.046  0.323
2005 Wu Q, Hwang CK, Yao S, Law PY, Loh HH, Wei LN. A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal. Molecular Pharmacology. 68: 279-85. PMID 15879516 DOI: 10.1124/Mol.105.012567  0.729
2005 Yoo JH, Cho JH, Lee SY, Loh HH, Ho IK, Jang CG. Reduced nNOS expression induced by repeated nicotine treatment in mu-opioid receptor knockout mice. Neuroscience Letters. 380: 70-4. PMID 15854753 DOI: 10.1016/J.Neulet.2005.01.001  0.315
2005 Marker CL, Luján R, Loh HH, Wickman K. Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3551-9. PMID 15814785 DOI: 10.1523/Jneurosci.4899-04.2005  0.324
2005 Tien LT, Fan LW, Ma T, Loh HH, Ho IK. Roles of mu-opioid receptors in development of tolerance to diisopropylfluorophosphate (DFP). The Journal of Toxicological Sciences. 30: 43-59. PMID 15800401 DOI: JST.JSTAGE/jts/30.43  0.343
2005 Roy S, Guo X, Kelschenbach J, Liu Y, Loh HH. In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3229-33. PMID 15788780 DOI: 10.1523/Jneurosci.0332-05.2005  0.397
2005 Wang G, Liu T, Wei LN, Law PY, Loh HH. DNA methylation-related chromatin modification in the regulation of mouse delta-opioid receptor gene. Molecular Pharmacology. 67: 2032-9. PMID 15769948 DOI: 10.1124/Mol.105.011056  0.543
2005 Liao D, Lin H, Law PY, Loh HH. Mu-opioid receptors modulate the stability of dendritic spines. Proceedings of the National Academy of Sciences of the United States of America. 102: 1725-30. PMID 15659552 DOI: 10.1073/Pnas.0406797102  0.669
2005 Claude-Geppert PA, Liu J, Solberg J, Erickson-Herbrandson LJ, Loh HH, Law PY. Antagonist efficacy in MORS196L mutant is affected by the interaction between transmembrane domains of the opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 313: 216-26. PMID 15579496 DOI: 10.1124/Jpet.104.076505  0.305
2004 Chen YL, Law PY, Loh HH. Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells. Cancer Research. 64: 8723-30. PMID 15574783 DOI: 10.1158/0008-5472.Can-03-3091  0.419
2004 Law PY, Loh HH, Wei LN. Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence. Neuropharmacology. 47: 300-11. PMID 15464146 DOI: 10.1016/J.Neuropharm.2004.07.013  0.35
2004 Tien LT, Fan LW, Ma T, Loh HH, Ho IK. Increased diisopropylfluorophosphate-induced toxicity in mu-opioid receptor knockout mice. Journal of Neuroscience Research. 78: 259-67. PMID 15378609 DOI: 10.1002/Jnr.20259  0.344
2004 Tien LT, Fan LW, Sogawa C, Ma T, Loh HH, Ho IK. Changes in acetylcholinesterase activity and muscarinic receptor bindings in mu-opioid receptor knockout mice. Brain Research. Molecular Brain Research. 126: 38-44. PMID 15207914 DOI: 10.1016/j.molbrainres.2004.03.011  0.306
2004 Wei LN, Law PY, Loh HH. Post-transcriptional regulation of opioid receptors in the nervous system. Frontiers in Bioscience : a Journal and Virtual Library. 9: 1665-79. PMID 14977578  0.308
2004 Grecksch G, Becker A, Schroeder H, Kraus J, Loh H, Höllt V. Accelerated kindling development in mu-opioid receptor deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 369: 287-93. PMID 14963640 DOI: 10.1007/s00210-004-0870-4  0.337
2003 Mizoguchi H, Wu HE, Narita M, Sora I, Hall SF, Uhl GR, Loh HH, Nagase H, Tseng LF. Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene. Journal of Pharmacological Sciences. 93: 423-9. PMID 14737012 DOI: 10.1254/jphs.93.423  0.349
2003 Portoghese PS, Law PY, Loh HH. Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens. European Journal of Pharmacology. 478: 207-10. PMID 14575806 DOI: 10.1016/J.Ejphar.2003.08.041  0.383
2003 Chan AS, Law PY, Loh HH, Ho PN, Wu WM, Chan JS, Wong YH. The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with Galpha16. Journal of Neurochemistry. 87: 697-708. PMID 14535952 DOI: 10.1046/J.1471-4159.2003.02040.X  0.358
2003 Wang G, Wei LN, Loh HH. Transcriptional regulation of mouse delta-opioid receptor gene by CpG methylation: involvement of Sp3 and a methyl-CpG-binding protein, MBD2, in transcriptional repression of mouse delta-opioid receptor gene in Neuro2A cells. The Journal of Biological Chemistry. 278: 40550-6. PMID 12890683 DOI: 10.1074/Jbc.M302879200  0.576
2003 Guo XH, Fairbanks CA, Stone LS, Loh HH. DPDPE-UK14,304 synergy is retained in mu opioid receptor knockout mice. Pain. 104: 209-17. PMID 12855331 DOI: 10.1016/S0304-3959(03)00007-1  0.344
2003 Wang W, Loh HH, Law PY. The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells. The Journal of Biological Chemistry. 278: 36848-58. PMID 12851402 DOI: 10.1074/Jbc.M301540200  0.315
2003 Wang J, Barke RA, Charboneau R, Loh HH, Roy S. Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways. The Journal of Biological Chemistry. 278: 37622-31. PMID 12842891 DOI: 10.1074/Jbc.M301224200  0.358
2003 Tien LT, Park Y, Fan LW, Ma T, Loh HH, Ho IK. Increased dopamine D2 receptor binding and enhanced apomorphine-induced locomotor activity in mu-opioid receptor knockout mice. Brain Research Bulletin. 61: 109-15. PMID 12788214 DOI: 10.1016/S0361-9230(03)00077-7  0.311
2003 Yoo JH, Yang EM, Lee SY, Loh HH, Ho IK, Jang CG. Differential effects of morphine and cocaine on locomotor activity and sensitization in mu-opioid receptor knockout mice. Neuroscience Letters. 344: 37-40. PMID 12781916 DOI: 10.1016/S0304-3940(03)00410-5  0.343
2003 Park Y, Jang CG, Yang KH, Loh HH, Ma T, Ho IK. Regional specific increases of [3H]AMPA binding and mRNA expression of AMPA receptors in the brain of mu-opioid receptor knockout mice. Brain Research. Molecular Brain Research. 113: 116-23. PMID 12750013  0.311
2003 Chaipatikul V, Loh HH, Law PY. Ligand-selective activation of mu-oid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain. The Journal of Pharmacology and Experimental Therapeutics. 305: 909-18. PMID 12626655 DOI: 10.1124/Jpet.102.046219  0.347
2003 Tomassini N, Renaud FL, Roy S, Loh HH. Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages. Journal of Neuroimmunology. 136: 9-16. PMID 12620638 DOI: 10.1016/S0165-5728(02)00463-0  0.384
2003 Yang W, Law PY, Guo X, Loh HH. In vivo activation of a mutant mu-opioid receptor by antagonist: future direction for opiate pain treatment paradigm that lacks undesirable side effects. Proceedings of the National Academy of Sciences of the United States of America. 100: 2117-21. PMID 12525693 DOI: 10.1073/Pnas.0334906100  0.65
2003 Hwang CK, Wu X, Wang G, Kim CS, Loh HH. Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. The Journal of Biological Chemistry. 278: 3742-50. PMID 12446692 DOI: 10.1074/Jbc.M208780200  0.617
2002 Mizoguchi H, Wu HE, Narita M, Loh HH, Nagase H, Tseng LF. Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene. Neuroscience Letters. 335: 91-4. PMID 12459506 DOI: 10.1016/S0304-3940(02)01171-0  0.324
2002 Wang J, Charboneau R, Balasubramanian S, Barke RA, Loh HH, Roy S. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. Journal of Leukocyte Biology. 71: 782-90. PMID 11994502 DOI: 10.1189/Jlb.71.5.782  0.387
2002 Sasaki K, Fan LW, Tien LT, Ma T, Loh HH, Ho IK. The interaction of morphine and gamma-aminobutyric acid (GABA)ergic systems in anxiolytic behavior: using mu-opioid receptor knockout mice. Brain Research Bulletin. 57: 689-94. PMID 11927374 DOI: 10.1016/S0361-9230(01)00785-7  0.382
2002 Wei LN, Loh HH. Regulation of opioid receptor expression. Current Opinion in Pharmacology. 2: 69-75. PMID 11786311  0.309
2001 Chen HC, Loh HH. mu-Opioid receptor gene expression: the role of NCAM. Neuroscience. 108: 7-15. PMID 11738127  0.318
2001 Jang CG, Lee SY, Park Y, Ma T, Loh HH, Ho IK. Differential effects of morphine, DPDPE, and U-50488 on apomorphine-induced climbing behavior in mu-opioid receptor knockout mice. Brain Research. Molecular Brain Research. 94: 197-9. PMID 11597780 DOI: 10.1016/S0169-328X(01)00227-3  0.353
2001 Wang J, Charboneau R, Balasubramanian S, Barke RA, Loh HH, Roy S. Morphine modulates lymph node-derived T lymphocyte function: role of caspase-3, -8, and nitric oxide. Journal of Leukocyte Biology. 70: 527-36. PMID 11590188  0.34
2001 Lichtman AH, Sheikh SM, Loh HH, Martin BR. Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 298: 1007-14. PMID 11504797  0.38
2001 Roy S, Wang JH, Balasubramanian S, Sumandeep, Charboneau R, Barke R, Loh HH. Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout mice. Journal of Neuroimmunology. 116: 147-55. PMID 11438169 DOI: 10.1016/S0165-5728(01)00299-5  0.35
2001 Portoghese PS, el Kouhen R, Law PY, Loh HH, Le Bourdonnec B. Affinity labels as tools for the identification of opioid receptor recognition sites. Farmaco (Societã  Chimica Italiana : 1989). 56: 191-6. PMID 11409326 DOI: 10.1016/S0014-827X(01)01040-0  0.349
2001 Park Y, Ho IK, Jang CG, Tanaka S, Ma T, Loh HH, Ko KH. Effects of morphine on pentobarbital-induced responses in mu-opioid receptor knockout mice. Brain Research Bulletin. 54: 527-31. PMID 11397543 DOI: 10.1016/S0361-9230(01)00444-0  0.373
2001 Le Bourdonnec B, El Kouhen R, Poda G, Law PY, Loh HH, Ferguson DM, Portoghese PS. Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI). Journal of Medicinal Chemistry. 44: 1017-20. PMID 11297446 DOI: 10.1021/Jm010004U  0.345
2000 Kouhen OM, Wang G, Solberg J, Erickson LJ, Law PY, Loh HH. Hierarchical phosphorylation of delta-opioid receptor regulates agonist-induced receptor desensitization and internalization. The Journal of Biological Chemistry. 275: 36659-64. PMID 10973976 DOI: 10.1074/Jbc.M006788200  0.587
2000 Law PY, Erickson LJ, El-Kouhen R, Dicker L, Solberg J, Wang W, Miller E, Burd AL, Loh HH. Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor. Molecular Pharmacology. 58: 388-98. PMID 10908307 DOI: 10.1124/Mol.58.2.388  0.309
2000 Jang C, Park Y, Tanaka S, Ma T, Loh HH, Ho IK. Involvement of mu-opioid receptors in potentiation of apomorphine-induced climbing behavior by morphine: studies using mu-opioid receptor gene knockout mice. Brain Research. Molecular Brain Research. 78: 204-6. PMID 10891603 DOI: 10.1016/S0169-328X(00)00094-2  0.368
2000 Le Bourdonnec B, El Kouhen R, Lunzer MM, Law PY, Loh HH, Portoghese PS. Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors. Journal of Medicinal Chemistry. 43: 2489-92. PMID 10891107 DOI: 10.1021/Jm000138S  0.367
2000 Becker A, Grecksch G, Brödemann R, Kraus J, Peters B, Schroeder H, Thiemann W, Loh HH, Höllt V. Morphine self-administration in mu-opioid receptor-deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 361: 584-9. PMID 10882032  0.359
2000 Park Y, Ma T, Tanaka S, Jang C, Loh HH, Ko KH, Ho IK. Comparison of G-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice. Brain Research Bulletin. 52: 297-302. PMID 10856828 DOI: 10.1016/S0361-9230(00)00265-3  0.366
2000 Law PY, Wong YH, Loh HH. Molecular mechanisms and regulation of opioid receptor signaling. Annual Review of Pharmacology and Toxicology. 40: 389-430. PMID 10836142 DOI: 10.1146/Annurev.Pharmtox.40.1.389  0.304
2000 Chen H, Seybold VS, Loh HH. An autoradiographic study in mu-opioid receptor knockout mice. Brain Research. Molecular Brain Research. 76: 170-2. PMID 10719227 DOI: 10.1016/S0169-328X(99)00346-0  0.365
1999 Yoon SH, Lo TM, Loh HH, Thayer SA. Delta-opioid-induced liberation of Gbetagamma mobilizes Ca2+ stores in NG108-15 cells. Molecular Pharmacology. 56: 902-8. PMID 10531393 DOI: 10.1124/Mol.56.5.902  0.301
1999 Liu HC, Shen JT, Augustin LB, Ko JL, Loh HH. Transcriptional regulation of mouse delta-opioid receptor gene. The Journal of Biological Chemistry. 274: 23617-26. PMID 10438544  0.316
1999 Chen HC, Wei LN, Loh HH. Expression of mu-, kappa- and delta-opioid receptors in P19 mouse embryonal carcinoma cells. Neuroscience. 92: 1143-55. PMID 10426553 DOI: 10.1016/S0306-4522(99)00030-5  0.314
1999 Im HJ, Kang SW, Loh HH. Opioid receptor gene: cytokine response element and the effect of cytokines. Brain Research. 829: 174-9. PMID 10350544  0.307
1999 Law PY, Loh HH. Regulation of opioid receptor activities. The Journal of Pharmacology and Experimental Therapeutics. 289: 607-24. PMID 10215631  0.338
1998 Roy S, Barke RA, Loh HH. MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Brain Research. Molecular Brain Research. 61: 190-4. PMID 9795212 DOI: 10.1016/S0169-328X(98)00212-5  0.389
1998 Chakrabarti S, Law PY, Loh HH. Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation. Journal of Neurochemistry. 71: 231-9. PMID 9648870 DOI: 10.1046/j.1471-4159.1998.71010231.x  0.363
1998 Roy S, Liu HC, Loh HH. mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Research. Molecular Brain Research. 56: 281-3. PMID 9602153 DOI: 10.1016/S0169-328X(98)00051-5  0.357
1998 Tao PL, Han KF, Wang SD, Lue WM, Elde R, Law PY, Loh HH. Immunohistochemical evidence of down-regulation of mu-opioid receptor after chronic PL-017 in rats. European Journal of Pharmacology. 344: 137-42. PMID 9600647 DOI: 10.1016/S0014-2999(97)01596-3  0.368
1998 Loh HH, Liu HC, Cavalli A, Yang W, Chen YF, Wei LN. mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Research. Molecular Brain Research. 54: 321-6. PMID 9555078 DOI: 10.1016/S0169-328X(97)00353-7  0.651
1998 Afify EA, Law PY, Riedl M, Elde R, Loh HH. Role of carboxyl terminus of mu-and delta-opioid receptor in agonist-induced down-regulation. Brain Research. Molecular Brain Research. 54: 24-34. PMID 9526035 DOI: 10.1016/S0169-328X(97)00315-X  0.306
1997 Spencer RJ, Jin W, Thayer SA, Chakrabarti S, Law PY, Loh HH. Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes. Biochemical Pharmacology. 54: 809-18. PMID 9353135 DOI: 10.1016/S0006-2952(97)00243-8  0.326
1997 Chakrabarti S, Yang W, Law PY, Loh HH. The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Molecular Pharmacology. 52: 105-13. PMID 9224819  0.324
1997 Law PY, McGinn TM, Campbell KM, Erickson LE, Loh HH. Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner. Molecular Pharmacology. 51: 152-60. PMID 9016358 DOI: 10.1124/Mol.51.1.152  0.356
1996 Sedqi M, Roy S, Ramakrishnan S, Loh HH. Expression cloning of a full-length cDNA encoding delta opioid receptor from mouse thymocytes. Journal of Neuroimmunology. 65: 167-70. PMID 8964899 DOI: 10.1016/0165-5728(96)00028-8  0.331
1996 Roy S, Loh HH. Effects of opioids on the immune system. Neurochemical Research. 21: 1375-86. PMID 8947928 DOI: 10.1007/Bf02532379  0.339
1996 Claude PA, Wotta DR, Zhang XH, Prather PL, McGinn TM, Erickson LJ, Loh HH, Law PY. Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists. Proceedings of the National Academy of Sciences of the United States of America. 93: 5715-9. PMID 8650158 DOI: 10.1073/pnas.93.12.5715  0.35
1996 Roy S, Sedqi M, Ramakrishnan S, Barke RA, Loh HH. Differential effects of opioids on the proliferation of a macrophage cell line, Bac 1.2F5. Cellular Immunology. 169: 271-7. PMID 8620555 DOI: 10.1006/Cimm.1996.0118  0.325
1996 Wick MJ, Minnerath SR, Roy S, Ramakrishnan S, Loh HH. Differential expression of opioid receptor genes in human lymphoid cell lines and peripheral blood lymphocytes. Journal of Neuroimmunology. 64: 29-36. PMID 8598387 DOI: 10.1016/0165-5728(95)00144-1  0.32
1995 Piros ET, Prather PL, Loh HH, Law PY, Evans CJ, Hales TG. Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells. Molecular Pharmacology. 47: 1041-9. PMID 7746271  0.344
1995 Sedqi M, Roy S, Ramakrishnan S, Elde R, Loh HH. Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages. Biochemical and Biophysical Research Communications. 209: 563-74. PMID 7733926 DOI: 10.1006/Bbrc.1995.1538  0.379
1995 Chakrabarti S, Law PY, Loh HH. Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine. Brain Research. Molecular Brain Research. 30: 269-78. PMID 7637578 DOI: 10.1016/0169-328X(95)00014-J  0.395
1995 Elde R, Arvidsson U, Riedl M, Vulchanova L, Lee JH, Dado R, Nakano A, Chakrabarti S, Zhang X, Loh HH. Distribution of neuropeptide receptors. New views of peptidergic neurotransmission made possible by antibodies to opioid receptors. Annals of the New York Academy of Sciences. 757: 390-404. PMID 7611696 DOI: 10.1111/J.1749-6632.1995.Tb17497.X  0.316
1995 Arvidsson U, Riedl M, Chakrabarti S, Vulchanova L, Lee JH, Nakano AH, Lin X, Loh HH, Law PY, Wessendorf MW. The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Proceedings of the National Academy of Sciences of the United States of America. 92: 5062-6. PMID 7539141 DOI: 10.1073/pnas.92.11.5062  0.319
1995 Wick MJ, Minnerath SR, Roy S, Ramakrishnan S, Loh HH. Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. Brain Research. Molecular Brain Research. 32: 342-7. PMID 7500847 DOI: 10.1016/0169-328X(95)00096-B  0.32
1995 Wick MJ, Ann DK, Loh HH. Molecular cloning of a novel protein regulated by opioid treatment of NG108-15 cells. Brain Research. Molecular Brain Research. 32: 171-5. PMID 7494458  0.317
1994 Law PY, McGinn TM, Wick MJ, Erikson LJ, Evans C, Loh HH. Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density? The Journal of Pharmacology and Experimental Therapeutics. 271: 1686-94. PMID 7996485  0.364
1994 Wick MJ, Minnerath SR, Lin X, Elde R, Law PY, Loh HH. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors. Brain Research. Molecular Brain Research. 27: 37-44. PMID 7877452 DOI: 10.1016/0169-328X(94)90181-3  0.325
1993 Govitrapong P, Zhang X, Loh HH, Lee NM. Transfection of NG108-15 cells with antisense opioid-binding cell adhesion molecule cDNA alters opioid receptor-G-protein interaction. The Journal of Biological Chemistry. 268: 18280-5. PMID 8394363  0.347
1993 Law PY, Loh HH. delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells. Molecular Pharmacology. 43: 684-93. PMID 8388986  0.377
1993 Tao PL, Seybold VS, Loh HH. Autoradiographic evidence for decrease in binding of mu- and delta-opioid receptors after subchronic [D-Ala2,D-Leu5]enkephalin treatment in rats. European Journal of Pharmacology. 231: 145-9. PMID 8384111 DOI: 10.1016/0014-2999(93)90442-K  0.348
1993 Tao PL, Chang LR, Chou YP, Law PY, Loh HH. Chronic opioid treatment may uncouple opioid receptors and G-proteins: evidence from radiation inactivation analysis. European Journal of Pharmacology. 246: 233-8. PMID 8223946 DOI: 10.1016/0922-4106(93)90036-9  0.378
1993 Tao PL, Lee CR, Law PY, Loh HH. The interaction of the mu-opioid receptor and G protein is altered after chronic morphine treatment in rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 348: 504-8. PMID 8114950  0.389
1993 Takemori AE, Loh HH, Lee NM. Suppression by dynorphin A and [des-Tyr1]dynorphin A peptides of the expression of opiate withdrawal and tolerance in morphine-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 266: 121-4. PMID 8101214  0.315
1992 Takemori AE, Loh HH, Lee NM. Suppression by dynorphin A-(1-13) of the expression of opiate withdrawal and tolerance in mice. European Journal of Pharmacology. 221: 223-6. PMID 1358653 DOI: 10.1016/0014-2999(92)90705-9  0.343
1992 Lane CM, Elde R, Loh HH, Lee NM. Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors. Proceedings of the National Academy of Sciences of the United States of America. 89: 11234-8. PMID 1333602 DOI: 10.1073/Pnas.89.23.11234  0.385
1992 Roy S, Ge BL, Loh HH, Lee NM. Characterization of [3H]morphine binding to interleukin-1-activated thymocytes. The Journal of Pharmacology and Experimental Therapeutics. 263: 451-6. PMID 1331399  0.325
1992 Ko JL, Lee NM, Loh HH. Characterization of beta-125I-endorphin cross-linked proteins in NG108-15 cell membranes. A 25-kilodalton protein with properties of delta-opioid-binding site. The Journal of Biological Chemistry. 267: 12722-7. PMID 1320002  0.345
1992 Ann DK, Hasegawa J, Ko JL, Chen ST, Lee NM, Loh HH. Specific reduction of delta-opioid receptor binding in transfected NG108-15 cells. The Journal of Biological Chemistry. 267: 7921-6. PMID 1313812  0.312
1991 Law PY, Hom DS, Loh HH. Effect of chronic D-Ala,2 D-Leu5-enkephalin or pertussis toxin treatment on the high-affinity state of delta opioid receptor in neuroblastoma x glioma NG108-15 hybrid cells. The Journal of Pharmacology and Experimental Therapeutics. 256: 710-6. PMID 1847209  0.326
1991 Roy S, Ramakrishnan S, Loh HH, Lee NM. Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrow. European Journal of Pharmacology. 195: 359-63. PMID 1831136 DOI: 10.1016/0014-2999(91)90476-7  0.309
1991 Roy S, Loh HH, Lee NM. Dynorphin blocks opioid inhibition of macrophage-colony stimulating factor-induced proliferation of bone marrow cells. European Journal of Pharmacology. 202: 355-9. PMID 1684159 DOI: 10.1016/0014-2999(91)90278-X  0.358
1991 Tao PL, Tsai CL, Chang LR, Loh HH. Chronic effect of [D-Pen2,D-Pen5]enkephalin on rat brain opioid receptors. European Journal of Pharmacology. 201: 209-14. PMID 1665782  0.355
1991 Smith AP, Loh HH. Problems and approaches in studying membrane opioid receptors. Nida Research Monograph. 111: 69-84. PMID 1663582  0.323
1991 Roy S, Ge BL, Ramakrishnan S, Lee NM, Loh HH. [3H]morphine binding is enhanced by IL-1-stimulated thymocyte proliferation. Febs Letters. 287: 93-6. PMID 1652466 DOI: 10.1016/0014-5793(91)80023-V  0.31
1990 Wu CS, Hasegawa J, Smith AP, Loh HH, Lee NM, Yang JT. Opioid-binding protein (OBCAM) is rich in beta-sheets. Journal of Protein Chemistry. 9: 3-7. PMID 2340074 DOI: 10.1007/Bf01024977  0.342
1990 Tao PL, Lee HY, Chang LR, Loh HH. Decrease in mu-opioid receptor binding capacity in rat brain after chronic PL017 treatment. Brain Research. 526: 270-5. PMID 2175241 DOI: 10.1016/0006-8993(90)91231-5  0.483
1990 Loh HH, Smith AP. Molecular characterization of opioid receptors. Annual Review of Pharmacology and Toxicology. 30: 123-47. PMID 2160790 DOI: 10.1146/Annurev.Pa.30.040190.001011  0.479
1990 Louie AK, Bass ES, Zhan J, Law PY, Loh HH. Attenuation of opioid receptor activity by phorbol esters in neuroblastoma x glioma NG108-15 hybrid cells. The Journal of Pharmacology and Experimental Therapeutics. 253: 401-7. PMID 2158550  0.358
1989 Hitzemann RJ, Hitzemann BA, Loh HH. Binding of 3H-naloxone in the mouse brain: effect of ions and tolerance development. Life Sciences. 14: 2393-404. PMID 4549965 DOI: 10.1016/0024-3205(74)90135-0  0.39
1989 Schofield PR, McFarland KC, Hayflick JS, Wilcox JN, Cho TM, Roy S, Lee NM, Loh HH, Seeburg PH. Molecular characterization of a new immunoglobulin superfamily protein with potential roles in opioid binding and cell contact. The Embo Journal. 8: 489-95. PMID 2721489 DOI: 10.1002/J.1460-2075.1989.Tb03402.X  0.324
1988 Roy S, Zhu YX, Loh HH, Lee NM. A monoclonal antibody that inhibits opioid binding to rat brain membranes. Biochemical and Biophysical Research Communications. 154: 688-93. PMID 3401228 DOI: 10.1016/0006-291X(88)90194-5  0.427
1988 Tao PL, Chang LR, Law PY, Loh HH. Decrease in delta-opioid receptor density in rat brain after chronic [D-Ala2,D-Leu5]enkephalin treatment. Brain Research. 462: 313-20. PMID 2847851 DOI: 10.1016/0006-8993(88)90559-8  0.486
1988 Loh HH, Tao PL, Smith AP. Role of receptor regulation in opioid tolerance mechanisms. Synapse (New York, N.Y.). 2: 457-62. PMID 2847342 DOI: 10.1002/Syn.890020414  0.495
1988 Louie AK, Zhan JN, Law PY, Loh HH. Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells. Biochemical and Biophysical Research Communications. 152: 1369-75. PMID 2837185 DOI: 10.1016/S0006-291X(88)80436-4  0.462
1988 Roy S, Zhu YX, Lee NM, Loh HH. Different molecular weight forms of opioid receptors revealed by polyclonal antibodies. Biochemical and Biophysical Research Communications. 150: 237-44. PMID 2827667 DOI: 10.1016/0006-291X(88)90511-6  0.433
1987 Abood ME, Lee NM, Loh HH. Modification of opioid agonist binding by pertussis toxin. Brain Research. 417: 70-4. PMID 3113672 DOI: 10.1016/0006-8993(87)90180-6  0.433
1987 Tao PL, Law PY, Loh HH. Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment. The Journal of Pharmacology and Experimental Therapeutics. 240: 809-16. PMID 3031275  0.341
1987 Hasegawa J, Loh HH, Lee NM. Lipid requirement for mu opioid receptor binding. Journal of Neurochemistry. 49: 1007-12. PMID 2887631 DOI: 10.1111/J.1471-4159.1987.Tb09987.X  0.424
1987 Roy S, Loh HH. Biological activity of mu opioid receptor. Neuropharmacology. 26: 917-21. PMID 2821434 DOI: 10.1016/0028-3908(87)90070-0  0.463
1986 Roy S, Lee NM, Loh HH. Mu-opioid receptor is associated with phosphatase activity. Biochemical and Biophysical Research Communications. 140: 660-5. PMID 3022726  0.346
1986 Tao PL, Chang LR, Lee HK, Loh HH. Determination of the sizes of the opioid receptors in their membrane environment by radiation inactivation. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences. 10: 184-90. PMID 3022321  0.339
1986 Griffin MT, Law PY, Loh HH. Effect of phospholipases on chronic opiate action in neuroblastoma X glioma NG108-15 hybrid cells. Journal of Neurochemistry. 47: 1098-105. PMID 3018158 DOI: 10.1111/J.1471-4159.1986.Tb00726.X  0.341
1986 Louie AK, Law PY, Loh HH. Cell-free desensitization of opioid inhibition of adenylate cyclase in neuroblastoma X glioma NG108-15 hybrid cell membranes. Journal of Neurochemistry. 47: 733-7. PMID 3016185 DOI: 10.1111/J.1471-4159.1986.Tb00673.X  0.426
1986 Cho TM, Hasegawa J, Ge BL, Loh HH. Purification to apparent homogeneity of a mu-type opioid receptor from rat brain. Proceedings of the National Academy of Sciences of the United States of America. 83: 4138-42. PMID 3012554 DOI: 10.1073/Pnas.83.12.4138  0.443
1986 Kuroda H, Baskin DS, Matsui T, Loh HH, Hosobuchi Y, Lee NM. Effects of dynorphin1-13 on opiate binding and dopamine and GABA uptake in stroked cat brain. Brain Research. 379: 68-74. PMID 2874866 DOI: 10.1016/0006-8993(86)90256-8  0.321
1985 Baskin DS, Hosobuchi Y, Loh HH, Lee NM. Dynorphin(1-13) improves survival in cats with focal cerebral ischaemia. Nature. 312: 551-2. PMID 6150441 DOI: 10.1038/312551A0  0.36
1985 Griffin MT, Law PY, Loh HH. Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells. Journal of Neurochemistry. 45: 1585-9. PMID 3930663 DOI: 10.1111/J.1471-4159.1985.Tb07230.X  0.364
1985 Woo SK, Hitzemann RJ, Loh HH. Specific opioid-amphetamine interactions in the caudate putamen. Psychopharmacology. 85: 371-6. PMID 3923524 DOI: 10.1007/Bf00428204  0.426
1985 Abood ME, Law PY, Loh HH. Pertussis toxin treatment modifies opiate action in the rat brain striatum. Biochemical and Biophysical Research Communications. 127: 477-83. PMID 3919730 DOI: 10.1016/S0006-291X(85)80185-6  0.386
1985 Cho TM, Ge BL, Loh HH. Isolation and purification of morphine receptor by affinity chromatography. Life Sciences. 36: 1075-85. PMID 2983166 DOI: 10.1016/0024-3205(85)90493-X  0.396
1985 Law PY, Ungar HG, Hom DS, Loh HH. Effects of cycloheximide and tunicamycin on opiate receptor activities in neuroblastoma X glioma NG108-15 hybrid cells. Biochemical Pharmacology. 34: 9-17. PMID 2981531 DOI: 10.1016/0006-2952(85)90093-0  0.359
1984 Woo SK, Tulunay FC, Loh HH, Lee NM. Effect of dynorphin-(1-13) and related peptides on respiratory rate and morphine-induced respiratory rate depression. European Journal of Pharmacology. 96: 117-22. PMID 6662192 DOI: 10.1016/0014-2999(83)90537-X  0.436
1984 Garzón J, Sánchez-Blázquez P, Gerhart J, Loh HH, Lee NM. Dynorphin1-13: interaction with other opiate ligand bindings in vitro. Brain Research. 302: 392-6. PMID 6329465 DOI: 10.1016/0006-8993(84)90256-7  0.428
1984 Garzón J, Sánchez-Blázquez P, Höllt V, Lee NM, Loh HH. Endogenous opioid peptides: comparative evaluation of their receptor affinities in the mouse brain. Life Sciences. 291-4. PMID 6319879 DOI: 10.1016/0024-3205(83)90500-3  0.39
1984 Garzón J, Sánchez-Blázquez P, Gerhart J, Loh HH, Lee NM. Dynorphin A: inhibitory effect on other opiate ligand bindings in the mouse brain. Biochemical Pharmacology. 33: 2609-14. PMID 6147144 DOI: 10.1016/0006-2952(84)90633-6  0.471
1984 Huidobro-Toro JP, Zhu YX, Lee NM, Loh HH, Way EL. Dynorphin inhibition of the neurotensin contractile activity on the myenteric plexus. The Journal of Pharmacology and Experimental Therapeutics. 228: 293-303. PMID 6141281  0.564
1983 Höllt V, Haarmann I, Grimm C, Herz A, Tulunay FC, Loh HH. Pro-enkephalin intermediates in bovine brain and adrenal medulla: characterization of immunoreactive peptides related to BAM-22P and peptide F. Life Sciences. 31: 1883-6. PMID 7154841 DOI: 10.1016/0024-3205(82)90234-X  0.304
1983 Höllt V, Tulunay FC, Woo SK, Loh HH, Herz A. Opioid peptides derived from pro-enkephalin A but not that from pro-enkephalin B are substantial analgesics after administration into brain of mice. European Journal of Pharmacology. 85: 355-6. PMID 7151878 DOI: 10.1016/0014-2999(82)90226-6  0.412
1983 Jen MF, Garzon J, Loh HH, Lee NM. Dynorphin-(1-13): the effect of in vivo treatment on opiate bindings in vitro. European Journal of Pharmacology. 91: 95-9. PMID 6311575 DOI: 10.1016/0014-2999(83)90367-9  0.36
1983 Cho TM, Ge BL, Yamato C, Smith AP, Loh HH. Isolation of opiate binding components by affinity chromatography and reconstitution of binding activities. Proceedings of the National Academy of Sciences of the United States of America. 80: 5176-80. PMID 6310562 DOI: 10.1073/Pnas.80.17.5176  0.371
1983 Law PY, Griffin MT, Koehler JE, Loh HH. Attenuation of enkephalin activity in neuroblastoma X glioma NG108-15 hybrid cells by phospholipases. Journal of Neurochemistry. 40: 267-75. PMID 6294248 DOI: 10.1111/J.1471-4159.1983.Tb12681.X  0.342
1983 Zhu YX, Höllt V, Loh H. Immunoreactive peptides related to dynorphin B (=rimorphin) in the rat brain Peptides. 4: 871-874. PMID 6143300 DOI: 10.1016/0196-9781(83)90083-9  0.335
1983 Woo S, Garzon J, Sanchez-Blazquez P, Tulunay FC, Chang JK, Loh HH. Dynorphin(1-10)amide: a potent and selective analog of dynorphin(1-13). Life Sciences. 31: 1817-20. PMID 6130447 DOI: 10.1016/0024-3205(82)90218-1  0.423
1983 Tulunay FC, Jen MF, Loh HH. Possible physiological control of morphine analgesia in mice. European Journal of Pharmacology. 83: 317-9. PMID 6129149 DOI: 10.1016/0014-2999(82)90269-2  0.493
1983 Smith AP, Lee NM, Loh HH. The multiple site β-endorphin receptor Trends in Pharmacological Sciences. 4: 163-164. DOI: 10.1016/0165-6147(83)90344-9  0.364
1982 Hitzemann R, Curell J, Hom D, Loh H. Effects of naloxone on d-amphetamine- and apomorphine-induced behavior Neuropharmacology. 21: 1005-1011. PMID 6890635 DOI: 10.1016/0028-3908(82)90114-9  0.373
1982 Tulunay FC, Jen MF, Chang JK, Loh HH, Lee NM. Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy. European Journal of Pharmacology. 76: 235-9. PMID 6277644 DOI: 10.1016/0014-2999(81)90506-9  0.452
1982 Zhu YX, Huidobro-Toro JP, Lee NM, Loh HH, Way EL. Interaction of dynorphin with neurotensin on the guinea pig ileum myenteric plexus. Life Sciences. 31: 1825-8. PMID 6130449 DOI: 10.1016/0024-3205(82)90220-X  0.566
1982 Yoshimura K, Huidobro-Toro JP, Lee NM, Loh HH, Way EL. Activation of K-opiate sites by dynorphin in the myenteric plexus. Advances in Biochemical Psychopharmacology. 33: 91-8. PMID 6127009  0.42
1982 Huidobro-Toro JP, Caturay EM, Ling N, Lee NM, Loh HH, Way EL. Studies on the structural prerequisites for the activation of the beta-endorphin receptor on the rat vas deferens. The Journal of Pharmacology and Experimental Therapeutics. 222: 262-9. PMID 6123591  0.45
1981 Law PY, Wu J, Koehler JE, Loh HH. Demonstration and characterization of opiate inhibition of the striatal adenylate cyclase. Journal of Neurochemistry. 36: 1834-46. PMID 7241139 DOI: 10.1111/J.1471-4159.1981.Tb00438.X  0.35
1981 Lee NM, Friedman HJ, Loh HH. Effect of acute and chronic ethanol treatment on rat brain phospholipid turnover. Biochemical Pharmacology. 29: 2815-8. PMID 7192094 DOI: 10.1016/0006-2952(80)90016-7  0.312
1981 Hook VY, Stokes KB, Lee NM, Loh HH. Possible nuclear protein kinase regulation of homologous ribonucleic acid polymerases from small dense nuclei of mouse brain during morphine tolerance-dependence. Involvement of cyclic 3',5'-adenosine monophosphate. Biochemical Pharmacology. 30: 2313-8. PMID 6271139 DOI: 10.1016/0006-2952(81)90104-0  0.39
1981 Law PY, Ostwald TJ, Way EL, Loh HH. Interaction of diazosulfanilic acid and the opiate receptor: inhibition of specific binding to synaptic membranes and labeling of a membrane lipid stereospecifically protected by opioids. Molecular Pharmacology. 19: 355-66. PMID 6267443  0.511
1981 Cho TM, Yamato C, Cho JS, Loh HH. Solubilization of membrane bound opiate receptor from rat brain Life Sciences. 28: 2651-2657. PMID 6267392 DOI: 10.1016/0024-3205(81)90723-2  0.363
1981 Lee NM, Leybin L, Chang JK, Loh HH. Opiate and peptide interaction: effect of enkephalins on morphine analgesia. European Journal of Pharmacology. 68: 181-5. PMID 6258928 DOI: 10.1016/0014-2999(80)90319-2  0.49
1981 Tulunay FC, Jen MF, Chang JK, Loh HH, Lee NM. Possible regulatory role of dynorphin on morphine- and beta-endorphin-induced analgesia. The Journal of Pharmacology and Experimental Therapeutics. 219: 296-8. PMID 6116798  0.365
1981 Huidobro-Toro JP, Yoshimura K, Lee NM, Loh HH, Way EL. Dynorphin interaction at the kappa-opiate site. European Journal of Pharmacology. 72: 265-6. PMID 6113976 DOI: 10.1016/0014-2999(81)90284-3  0.513
1981 Friedman HJ, Jen MF, Chang JK, Lee NM, Loh HH. Dynorphin: a possible modulatory peptide on morphine or beta-endorphin analgesia in mouse. European Journal of Pharmacology. 69: 357-60. PMID 6111461 DOI: 10.1016/0014-2999(81)90483-0  0.394
1981 Law PY, Herz A, Loh HH. Demonstration and characterization of a stereospecific opiate receptor in the neuroblastoma N18TG2 cells. Journal of Neurochemistry. 33: 1177-87. PMID 233241 DOI: 10.1111/J.1471-4159.1979.Tb05262.X  0.406
1981 Smith AP, Loh HH. The clinical relevance of opiate receptor research Drug Development Research. 1: 329-341. DOI: 10.1002/Ddr.430010405  0.375
1980 Su CY, Lin CS, Peng C, Cheng CS, Loh HH, Li CH, Way EL. Suppression of morphine abstinence in heroin addicts by beta-endorphin. Advances in Biochemical Psychopharmacology. 22: 503-9. PMID 7395604  0.521
1980 Menon MK, Tseng LF, Loh HH, Clark WG. An electromyographic method for the assessment of naloxone-induced abstinence in morphine-dependent rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 312: 43-9. PMID 7190227 DOI: 10.1007/Bf00502573  0.47
1980 Stokes KB, Lee NM, Loh HH. Mouse brain DNA-dependent RNA polymerases after chronic morphine treatment. Journal of Neurochemistry. 34: 1058-64. PMID 7189548 DOI: 10.1111/J.1471-4159.1980.Tb09939.X  0.34
1980 Hook VY, Lee NM, Loh HH. Partial purification of nuclear protein kinase from small dense nuclei of mouse brain and the effect of chronic morphine treatment. Journal of Neurochemistry. 34: 1274-9. PMID 6246205 DOI: 10.1111/J.1471-4159.1980.Tb09971.X  0.383
1980 Craves FB, Zalc B, Leybin L, Baumann N, Loh HH. Antibodies to cerebroside sulfate inhibit the effects of morphine and beta-endorphin. Science (New York, N.Y.). 207: 75-6. PMID 6243189 DOI: 10.1126/Science.6243189  0.424
1980 Hitzemann R, Wu J, Hom D, Loh HH. Brain locations controlling the behavioral effects of chronic amphetamine intoxication Psychopharmacology. 72: 93-101. PMID 6162168 DOI: 10.1007/Bf00433812  0.33
1980 Menon MK, Tseng LF, Loh HH, Clark WG. An electromyographic method for the quantitative evaluation of narcotic analgesics in rats. Neuropharmacology. 19: 231-6. PMID 6106906 DOI: 10.1016/0028-3908(80)90144-6  0.451
1979 Holaday JW, Law PY, Loh HH, Li CH. Adrenal steroids indirectly modulate morphine and beta-endorphin effects. The Journal of Pharmacology and Experimental Therapeutics. 208: 176-83. PMID 762650  0.365
1979 Tseng LF, Loh HH, Li CH. [D-Thr2, Thz5]-enkephalinamide: a potent analgesic by subcutaneous and oral administration. Life Sciences. 23: 2053-6. PMID 569237 DOI: 10.1016/0024-3205(78)90238-2  0.334
1979 Ho IK, Loh HH, Way EL. Toxic interaction between choline and morphine. Toxicology and Applied Pharmacology. 51: 203-8. PMID 531887 DOI: 10.1016/0041-008X(79)90462-9  0.611
1979 Harris RA, Wu YC, Loh HH. Brain sulfatide and non-lipid sulfate metabolism in leucodystrophic (jimpy) mice. Research Communications in Chemical Pathology and Pharmacology. 25: 377-88. PMID 493721  0.33
1979 Harris RA, Loh HH. Brain sulfatide and non-lipid sulfate metabolism in hypothyroid rats. Research Communications in Chemical Pathology and Pharmacology. 24: 169-79. PMID 432433  0.308
1979 Natsuki R, Hitzemann RJ, Loh HH. Influence of morphine, beta-endorphin and naloxone on the synthesis of phosphoinositides in the rat midbrain. Research Communications in Chemical Pathology and Pharmacology. 24: 233-50. PMID 223211  0.372
1979 Holaday JW, Dallman MF, Loh HH. Effects of hypophysectomy and ACTH on opiate tolerance and physical dependence. Life Sciences. 24: 771-81. PMID 221770 DOI: 10.1016/0024-3205(79)90360-6  0.469
1979 Loh HH, Cho TM, Cho JS, Way EL. Narcotic binding to membrane acidic lipids. Progress in Clinical and Biological Research. 27: 27-49. PMID 218232  0.404
1979 Tseng LF, Ostwald TJ, Loh HH, Li CH. Behavioral activities of opioid peptides and morphine sulfate in golden hamsters and rats. Psychopharmacology. 64: 215-218. PMID 115044 DOI: 10.1007/Bf00496065  0.416
1979 Harris RA, Snell D, Loh HH. Effects of chronic d-amphetamine treatment on schedule-controlled behavior. Psychopharmacology. 63: 55-61. PMID 112622 DOI: 10.1007/Bf00426922  0.42
1978 Huidobro-Toro JP, Harris RA, Loh HH, Way EL. Effects of hypothyroidism on the response of the rat colon to morphine. European Journal of Pharmacology. 52: 191-5. PMID 729631 DOI: 10.1016/0014-2999(78)90205-4  0.667
1978 Tseng LF, Loh HH, Li CH. betah-endorphin: antidiuretic effects in rats. International Journal of Peptide and Protein Research. 12: 173-6. PMID 700922 DOI: 10.1111/J.1399-3011.1978.Tb02882.X  0.458
1978 Schmidt WK, Holaday JW, Loh HH, Way EL. Failure vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development. Life Sciences. 23: 151-8. PMID 682877 DOI: 10.1016/0024-3205(78)90264-3  0.65
1978 Iwamoto ET, Harris RA, Loh HH, Way EL. Antinociceptive responses after microinjection of morphine or lanthanum in discrete rat brain sites. The Journal of Pharmacology and Experimental Therapeutics. 206: 46-55. PMID 660557  0.623
1978 Yamamoto I, Ho IK, Loh HH. The antagonistic effects of 5-ethyl-5-(3-hydroxy-1-methylbutyl)-barbituric acid on pentobarbital narcosis in both naïve and tolerant mice. Life Sciences. 22: 1103-12. PMID 642718 DOI: 10.1016/0024-3205(78)90281-3  0.342
1978 Harris RA, Snell D, Loh HH. Effects of d-amphetamine, monomethoxyamphetamines and hallucinogens on schedule-controlled behavior. The Journal of Pharmacology and Experimental Therapeutics. 204: 103-17. PMID 619124  0.31
1978 Natsuki R, Hitzemann RJ, Hitzemann BA, Loh HH. Effect of pentobarbital on regional brain phospholipid synthesis. Biochemical Pharmacology. 26: 2095-100. PMID 588290 DOI: 10.1016/0006-2952(77)90257-X  0.32
1978 Craves FB, Loh HH, Meyerhoff JL. The effect of morphine tolerance and dependence on cell free protein synthesis. Journal of Neurochemistry. 31: 1309-16. PMID 568166 DOI: 10.1111/J.1471-4159.1978.Tb06256.X  0.412
1978 Yamamoto H, Harris RA, Loh HH, Way EL. Effects of acute and chronic morphine treatments on calcium localization and binding in brain. The Journal of Pharmacology and Experimental Therapeutics. 205: 255-64. PMID 565404  0.605
1978 Holaday JW, Wei E, Loh HH, Li CH. Endorphins may function in heat adaptation. Proceedings of the National Academy of Sciences of the United States of America. 75: 2923-7. PMID 275863 DOI: 10.1073/Pnas.75.6.2923  0.349
1978 Law PY, Harris RA, Loh HH, Way EL. Evidence for the involvement of cerebroside sulfate in opiate receptor binding: Studies with Azure A and jimpy mutant mice. The Journal of Pharmacology and Experimental Therapeutics. 207: 458-68. PMID 213557  0.645
1978 Loh HH, Law PY, Ostwald T, Cho TM, Way EL. Possible involvement of cerebroside sulfate in opiate receptor binding. Federation Proceedings. 37: 147-52. PMID 203492  0.521
1978 Holaday JW, Tseng LF, Loh HH, Li CH. Thyrotropin releasing hormone antagonizes beta endorphin hypothermia and catalepsy. Life Sciences. 22: 1537-44. PMID 97481 DOI: 10.1016/0024-3205(78)90009-7  0.323
1978 Holaday JW, Loh HH, Li CH. Unique behavioral effects of beta endorphin and their relationship to thermoregulation and hypothalamic function. Life Sciences. 22: 1525-36. PMID 97480 DOI: 10.1016/0024-3205(78)90008-5  0.332
1977 Oguri K, Lee NM, Loh HH. Apparent protein kinase activity in oligodendroglial chromatin after chronic morphine treatment. Biochemical Pharmacology. 25: 2371-6. PMID 999724 DOI: 10.1016/0006-2952(76)90030-7  0.408
1977 Hitzemann RJ, Loh HH. On the possible role of brain protein synthesis in functional barbiturate tolerance. European Journal of Pharmacology. 40: 163-73. PMID 991923 DOI: 10.1016/0014-2999(76)90366-6  0.323
1977 Harris RA, Snell D, Loh HH. Stereoselective effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) on schedule-controlled behavior. Pharmacology, Biochemistry, and Behavior. 7: 307-10. PMID 928488 DOI: 10.1016/0091-3057(77)90225-8  0.384
1977 Wei ET, Tseng LF, Loh HH, Li CH. Comparison of the behavioral effects of beta-endorphin and enkephalin analogs. Life Sciences. 21: 321-7. PMID 895369 DOI: 10.1016/0024-3205(77)90512-4  0.453
1977 Hitzemann RJ, Loh HH. Influence of chronic pentobarbital or morphine treatment on the incorporation of 32Pi and [3H]choline into rat synaptic plasma membranes. Biochemical Pharmacology. 26: 1087-9. PMID 880262 DOI: 10.1016/0006-2952(77)90250-7  0.35
1977 Harris RA, Snell D, Loh HH, Way EL. Behavioral interactions between naloxone and dopamine agonists. European Journal of Pharmacology. 43: 243-6. PMID 872878 DOI: 10.1016/0014-2999(77)90023-1  0.6
1977 Simpson DL, Thorne DR, Loh HH. Developmentally regulated lectin in neonatal rat brain [24] Nature. 266: 367-369. PMID 859603 DOI: 10.1038/266367A0  0.318
1977 Li CH, Yamashiro D, Tseng LF, Loh HH. Synthesis and analgesic activity of human beta-endorphin. Journal of Medicinal Chemistry. 20: 325-8. PMID 845862 DOI: 10.1021/Jm00213A001  0.358
1977 Tseng LF, Loh HH, Li CH. Human beta-endorphin: development of tolerance and behavioral activity in rats. Biochemical and Biophysical Research Communications. 74: 390-6. PMID 836295 DOI: 10.1016/0006-291X(77)90316-3  0.424
1977 Brase DA, Loh HH, Way EL. Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains. The Journal of Pharmacology and Experimental Therapeutics. 201: 368-74. PMID 558328  0.534
1977 Harris RA, Yamamoto H, Loh HH, Way EL. Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence. Life Sciences. 20: 501-5. PMID 557160 DOI: 10.1016/0024-3205(77)90393-9  0.641
1977 Loh HH, Lee NM, Harris RA. Alterations of macromolecule biosynthesis after chronic administration of opiates and ethanol. Advances in Experimental Medicine and Biology. 85: 65-86. PMID 339683  0.368
1977 Meglio M, Hosobuchi Y, Loh HH, Adams JE, Li CH. beta-Endorphin: behavioral and analgesic activity in cats. Proceedings of the National Academy of Sciences of the United States of America. 74: 774-6. PMID 265542 DOI: 10.1073/Pnas.74.2.774  0.346
1977 Law PY, Wei ET, Tseng LF, Loh HH, Way EL. Opioid properties of beta-lipotropin fragment 60-65, H-Arg-Try-Gly-Gly-Phe-Met-OH. Life Sciences. 20: 251-9. PMID 190506 DOI: 10.1016/0024-3205(77)90319-8  0.565
1977 Doneen BA, Chung D, Yamashiro D, Law PY, Loh HH, Li CH. beta-Endorphin: structure-activity relationships in the guinea pig ileum and opiate receptor binding assays. Biochemical and Biophysical Research Communications. 74: 656-62. PMID 189770 DOI: 10.1016/0006-291X(77)90353-9  0.329
1977 Tseng LF, Loh HH, Li CH. beta-Endorphin: cross tolerance to and cross physical dependence on morphine. Proceedings of the National Academy of Sciences of the United States of America. 73: 4187-9. PMID 186788 DOI: 10.1073/Pnas.73.11.4187  0.446
1977 Yamamoto H, Harris RA, Loh HH, Way EL. Effects of morphine tolerance and dependence on Mg++ dependent ATPase activity of synaptic vesicles. Life Sciences. 20: 1533-9. PMID 141578 DOI: 10.1016/0024-3205(77)90445-3  0.625
1977 Iwamoto ET, Craves FB, Loh HH, Meyerhoff JL, Way EL. Axonal transport in nigro-neostriatal neurons during morphine tolerance development and abstinence in rats. Journal of Neurochemistry. 28: 285-92. PMID 65446 DOI: 10.1111/J.1471-4159.1977.Tb07746.X  0.614
1977 Ho IK, Loh HH, Way EL. Morphine analgesia, tolerance and dependence in mice from different strains and vendors. The Journal of Pharmacy and Pharmacology. 29: 583-4. PMID 21275 DOI: 10.1111/J.2042-7158.1977.Tb11409.X  0.582
1977 YAMASHIRO D, TSENG L, DONEEN BA, LOH HH, LI CH. ChemInform Abstract: β-ENDORPHIN- SYNTHESIS AND MORPHINE-LIKE ACTIVITY OF ANALOGS WITH D-AMINO ACID RESIDUES IN POSITIONS 1,2,4 AND 5 Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/Chin.197750381  0.325
1976 Ho IK, Yamamoto I, Loh HH, Way EL. Effects of chronic administration of morphine on pentobarbital responses in the mouse. Biochemical Pharmacology. 25: 357-8. PMID 1267832 DOI: 10.1016/0006-2952(76)90229-X  0.61
1976 Cho TM, Cho JS, Loh HH. A model system for opiate-receptor interactions: Mechanism of opiate-cerebroside sulfate interaction Life Sciences. 18: 231-244. PMID 1256239 DOI: 10.1016/0024-3205(76)90030-8  0.335
1976 Lee NM, Ho I, Loh HH. Effect of chronic morphine treatment on brain chromatin template activities in mice. Biochemical Pharmacology. 24: 1983-7. PMID 1212249 DOI: 10.1016/0006-2952(75)90386-X  0.434
1976 Stolman S, Loh HH. Stabilization of brain free polysomes by morphine. Research Communications in Chemical Pathology and Pharmacology. 12: 419-24. PMID 1197923  0.314
1976 Yamamoto HA, Harris RA, Loh HH, Way EL. Calcium binding to brain membranes: effects of morphine tolerance. Proceedings of the Western Pharmacology Society. 19: 71-4. PMID 996029  0.598
1976 Harris R, Snell D, Loh HH, Way EL. Behavioral interactions of apomorphine, clonidine and naloxone: possible presynatpic involvement. Proceedings of the Western Pharmacology Society. 19: 448-51. PMID 996022  0.451
1976 Wei E, Loh H. Physical dependence of opiate-like peptides Science. 193: 1262-1263. PMID 986687 DOI: 10.1126/Science.986687  0.377
1976 Ho IK, Yamamoto I, Becker KE, Loh HH, Way EL. Enhancement of pentobarbital effect by continuous administration of morphine in the mouse. Life Sciences. 19: 357-65. PMID 986524 DOI: 10.1016/0024-3205(76)90039-4  0.596
1976 Iwamoto ET, Loh HH, Way EL. Dopaminergic-cholinergic interactions in naloxone-induced circling in morphine-dependent rats with nigral lesions. European Journal of Pharmacology. 38: 39-54. PMID 986306 DOI: 10.1016/0014-2999(76)90199-0  0.623
1976 Iwamoto ET, Loh HH, Way EL. Circling behavior in rats with 6-hydroxydopamine or electrolytic nigral lesions,. European Journal of Pharmacology. 37: 339-56. PMID 986305 DOI: 10.1016/0014-2999(76)90042-X  0.477
1976 Tseng LF, Loh HH, Li CH. Beta-Endorphin as a potent analgesic by intravenous injection. Nature. 263: 239-240. PMID 958477 DOI: 10.1038/263239A0  0.331
1976 Ho IK, Loh HH, Way EL. Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence. Life Sciences. 18: 1111-23. PMID 945436 DOI: 10.1016/0024-3205(76)90146-6  0.597
1976 Iwamoto ET, Loh HH, Way EL. Circling behavior after narcotic drugs and during naloxone-precipitated abstinence in rats with unilateral nigral lesions. The Journal of Pharmacology and Experimental Therapeutics. 197: 503-16. PMID 945346  0.548
1976 Brase DA, Iwamoto ET, Loh HH, Way EL. Reinitiation of sensitivity to naloxone by a single narcotic injection in postaddicted mice. The Journal of Pharmacology and Experimental Therapeutics. 197: 317-25. PMID 944771  0.546
1976 Wu YC, Cho TM, Loh HH, Way EL. Binding of narcotics and narcotic antagonists to triphosphoinositide. Biochemical Pharmacology. 25: 1551-3. PMID 942457 DOI: 10.1016/0006-2952(76)90078-2  0.519
1976 Hitzemann RJ, Loh HH. Influence of morphine on protein synthesis in discrete subcellular fractions of the rat brain. Research Communications in Chemical Pathology and Pharmacology. 14: 237-48. PMID 940957  0.317
1976 Wei E, Loh H, Way EL. Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat. European Journal of Pharmacology. 36: 227-9. PMID 816658 DOI: 10.1016/0014-2999(76)90276-4  0.509
1976 Loh HH, Brase DA, Sampath-Khanna S, Mar JB, Way EL, Li CH. beta-Endorphin in vitro inhibition of striatal dopamine release. Nature. 264: 567-8. PMID 187956 DOI: 10.1038/264567A0  0.51
1976 Harris RA, Loh HH, Way EL. Alterations in the efficacy of naloxone induced by stress, cyclic adenosine monophosphate, and morphine tolerance. European Journal of Pharmacology. 39: 1-10. PMID 183962 DOI: 10.1016/0014-2999(76)90107-2  0.697
1976 Harris RA, Loh HH, Way EL. Antinociceptive effects of lanthanum and cerium in nontolerant and morphine tolerant-dependent animals. The Journal of Pharmacology and Experimental Therapeutics. 196: 288-97. PMID 176345  0.651
1976 Way EL, Loh HH. Responsivity to naloxone during morphine dependence. Annals of the New York Academy of Sciences. 281: 252-61. PMID 14582 DOI: 10.1111/J.1749-6632.1976.Tb27936.X  0.629
1976 Way EL, Iwamoto ET, Khanna S, Ho IK, Shen F, Loh HH. Precipitation of abstinence-like syndrome in morphine-dependent mice by pargyline. The Journal of Pharmacology and Experimental Therapeutics. 199: 400-7. PMID 10429  0.586
1976 Loh HH, Tseng LF, Wei E, Li CH. beta-endorphin is a potent analgesic agent. Proceedings of the National Academy of Sciences of the United States of America. 73: 2895-8. PMID 8780 DOI: 10.1073/Pnas.73.8.2895  0.361
1975 Wei E, Sigel SS, Loh HH, Way EL. Central sites of naloxone-precipitated shaking in the anesthetized, morphine-dependent rat. The Journal of Pharmacology and Experimental Therapeutics. 195: 480-7. PMID 1238555  0.605
1975 Brase DA, Iwamoto ET, Loh HH, Way EL. Sensitization of mice to naloxone induced jumping after a single narcotic injection: effect of prior physical dependence. Proceedings of the Western Pharmacology Society. 18: 294-7. PMID 1237142  0.504
1975 Iwamoto ET, Craves RB, Loh HH, Meyerhof J, Way EL. Nigro-neostriatal dopaminergic activity and axonal protein transport during morphinization and withdrawal in rats. Proceedings of the Western Pharmacology Society. 18: 288-93. PMID 1237141  0.499
1975 Harris RA, Loh HH, Way EL. Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance. The Journal of Pharmacology and Experimental Therapeutics. 195: 488-98. PMID 1195132  0.592
1975 Harris RA, Iwamoto ET, Loh HH, Way EL. Analgetic effects of lanthanum: cross-tolerance with morphine. Brain Research. 100: 221-5. PMID 1182518 DOI: 10.1016/0006-8993(75)90264-4  0.657
1975 Cho JS, Cho TM, Loh HH, Way EL. Bindings of N-alkylnorketobemidone to cerebroside sulfate. Proceedings of the Western Pharmacology Society. 18: 298-301. PMID 1178683  0.4
1975 Harris RA, Iwamoto ET, Loh HH, Way EL. Site dependent analgesia after microinjection of morphine or lanthanum in rat brain. Proceedings of the Western Pharmacology Society. 18: 275-8. PMID 1178680  0.632
1975 Cho TM, Loh HH, Way EL. Physicochemical properties of opiate - cerebroside sulfate complex. Proceedings of the Western Pharmacology Society. 18: 176-80. PMID 1178664  0.401
1975 Way EL, Iwamoto ET, Bhargava HN, Loh HH. Adaptive cholinergic-dopaminergic responses in morphine dependence. Advances in Biochemical Psychopharmacology. 13: 169-84. PMID 1171581  0.548
1975 Tseng LF, MENON MK, Loh HH. Brain lesions modifying the abstinence signs in morphine-dependent rats. Neuropharmacology. 14: 247-50. PMID 1168866 DOI: 10.1016/0028-3908(75)90069-6  0.369
1975 Ho IK, Yamamoto I, Loh HH. A model for the rapid development of dispositional and functional tolerance to barbiturates. European Journal of Pharmacology. 30: 164-71. PMID 1168576 DOI: 10.1016/0014-2999(75)90096-5  0.314
1975 Tseng LF, Loh HH, Wei ET. Effects of clonidine on morphine withdrawal signs in the rat. European Journal of Pharmacology. 30: 93-9. PMID 1168138 DOI: 10.1016/0014-2999(75)90208-3  0.449
1975 Loh HH, Cho TM, Wu YC, Harris RA, Way EL. Opiate binding to cerebroside sulfate: a model system for opiate-receptor interaction. Life Sciences. 16: 1811-7. PMID 1152609 DOI: 10.1016/0024-3205(75)90281-7  0.62
1975 Wei E, Sigel S, Loh H, Way EL. Thyrotrophin-releasing hormone and shaking behaviour in rat. Nature. 253: 739-40. PMID 803644 DOI: 10.1038/253739A0  0.555
1975 Ho LK, Loh HH, Bhargava HN, Way EL. Effect of cyclic nucleotides and phosphodiesterase inhibition on morphine tolerance and physical dependence. Life Sciences. 16: 1895-1900. PMID 239298 DOI: 10.1016/0024-3205(75)90298-2  0.646
1975 Ho IK, Brase DA, Loh HH, Way EL. Influence of L-tryptophan on morphine analgesia, tolerance and physical dependence. The Journal of Pharmacology and Experimental Therapeutics. 193: 35-43. PMID 124349  0.613
1974 Brase DA, Tseng LF, Loh HH, Way EL. Cholinergic modification of naloxone-induced jumping in morphine dependent mice. European Journal of Pharmacology. 26: 1-8. PMID 4857603 DOI: 10.1016/0014-2999(74)90066-1  0.616
1974 Wei E, Tseng LF, Loh H, Way EL. Similarity of morphine abstinence signs to thermoregulatory behaviour. Nature. 247: 398-400. PMID 4856350 DOI: 10.1038/247398B0  0.603
1974 Loh HH, Cho TM, Wu YC, Way EL. Stereospecific binding of narcotics to brain cerebrosides. Life Sciences. 14: 2231-45. PMID 4847814 DOI: 10.1016/0024-3205(74)90105-2  0.583
1974 Loh HH, Hitzemann RJ. Effect of morphine on the turnover and synthesis of (leu-3H)-protein and (ch-14C)-phosphatidylcholine in discrete regions of the rat brain. Biochemical Pharmacology. 23: 1753-65. PMID 4842659 DOI: 10.1016/0006-2952(74)90402-X  0.382
1974 Loh H, Hitzemann R, Stolman S. Effect of d-amphetamine on brain protein synthesis. Toxicology and Applied Pharmacology. 26: 476-81. PMID 4767582 DOI: 10.1016/0041-008X(73)90284-6  0.324
1974 Way EL, Ho IK, Loh HH. Brain 5-hydroxytryptamine and cyclic AMP in morphine tolerance and dependence. Advances in Biochemical Psychopharmacology. 10: 219-31. PMID 4152551  0.582
1974 LOH HH, HITZEMANN RJ, WAY EL. EFFECT OF ACUTE MORPHINE ADMINISTRATION ON THE METABOLISM OF BRAIN CATECHOLAMINES Survey of Anesthesiology. 18: 19. DOI: 10.1097/00132586-197402000-00015  0.415
1973 Tseng LF, Wei E, Loh HH. Brain areas associated with bulbocapnine catalepsy. European Journal of Pharmacology. 22: 363-6. PMID 4738904 DOI: 10.1016/0014-2999(73)90040-X  0.321
1973 Ho IK, Loh HH, Way EL. Influence of 5,6-dihydroxytryptamine on morphine tolerance and physical dependence. European Journal of Pharmacology. 21: 331-6. PMID 4736075 DOI: 10.1016/0014-2999(73)90135-0  0.648
1973 Wei E, Loh HH, Way EL. Brain sites of precipitated abstinence in morphine-dependent rats. The Journal of Pharmacology and Experimental Therapeutics. 185: 108-15. PMID 4735025  0.562
1973 Wei E, Loh HH, Way EL. Quantitative aspects of precipitated abstinence in morphine-dependent rats. The Journal of Pharmacology and Experimental Therapeutics. 184: 398-403. PMID 4734580  0.565
1973 Wei E, Loh HH, Way EL. Neuroanatomical correlates of wet shake behavior in the rat. Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology. 12: 489-96. PMID 4715757 DOI: 10.1016/0024-3205(73)90342-1  0.585
1973 Loh HH, Hitzemann RJ, Way EL. Effect of acute morphine administration on the metabolism of brain catecholamines. Life Sciences. Pt. 1: Physiology and Pharmacology. 12: 33-41. PMID 4695839 DOI: 10.1016/0024-3205(73)90171-9  0.63
1973 Loh HH, Ho IK, Cho TM, Lipscomb W. Estimation of morphine by polyamide mini thin-layer chromatography. Journal of Chromatography. 76: 505-8. PMID 4689616 DOI: 10.1016/S0021-9673(01)96941-9  0.338
1973 Hitzemann RJ, Ho IK, Loh HH. Narcotic tolerance and dependence and serotonin turnover. Science (New York, N.Y.). 178: 645-7. PMID 4673631 DOI: 10.1126/Science.178.4061.645  0.316
1973 Way EL, Loh HH, Ho IK, Iwamoto ET, Wei E. Neuroanatomical and chemical correlates of naloxone-precipitated withdrawal. Advances in Biochemical Psychopharmacology. 8: 455-69. PMID 4604812  0.496
1973 Ho IK, Loh HH, Way EL. Effects of cyclic 3',5'-adenosine monophosphate on morphine tolerance and physical dependence. The Journal of Pharmacology and Experimental Therapeutics. 185: 347-57. PMID 4350038  0.575
1973 Ho IK, Loh HH, Way EL. Cyclic adenosine monophosphate antagonism of morphine analgesia. The Journal of Pharmacology and Experimental Therapeutics. 185: 336-46. PMID 4350037  0.597
1973 Hitzemann RJ, Loh HH. Effect of morphine on the transport of dopamine into mouse brain slices. European Journal of Pharmacology. 21: 121-9. PMID 4348734 DOI: 10.1016/0014-2999(73)90216-1  0.426
1972 Loh HH, Stolman S, Lee CY. Effect of 6-hydroxydopamine on the incorporation of 14 C-leucine into rat brain protein. Life Sciences. Pt. 1: Physiology and Pharmacology. 10: 1171-80. PMID 5139551 DOI: 10.1016/0024-3205(71)90277-3  0.317
1972 Ho IK, Loh HH, Way EL. Mini thin-layer chromatography in the detection of narcotics in urine from subjects on a methadone maintenance program. Journal of Chromatography. 65: 577-9. PMID 5017436 DOI: 10.1016/S0021-9673(00)85006-2  0.447
1972 Wei E, Loh H. Biological Sciences: Morphine Physical Dependence unaltered by Previous Dependence on Morphine Nature. 238: 396-397. PMID 4559582 DOI: 10.1038/238396A0  0.512
1972 Wei E, Loh HH, Way EL. Neuroanatomical correlates of morphine dependence. Science (New York, N.Y.). 177: 616-7. PMID 4558902 DOI: 10.1126/Science.177.4049.616  0.654
1972 Ho IK, Loh HH, Way EL. Effect of cyclic AMP on morphine analgesia tolerance and physical dependence. Nature. 238: 397-8. PMID 4340746 DOI: 10.1038/238397A0  0.549
1972 Ho IK, Lu SE, Stolman S, Loh HH, Way EL. Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 182: 155-65. PMID 4261222  0.589
1971 Loh HH, Shen FH, Way EL. Effect of dactinomycin on the acute toxicity and brain uptake of morphine. The Journal of Pharmacology and Experimental Therapeutics. 177: 326-31. PMID 5568790  0.545
1971 Chou WS, Ho AK, Loh HH. Neurohormones on brain adenyl cyclase activity in vivo. Nature: New Biology. 233: 280-1. PMID 4330830 DOI: 10.1038/Newbio233280A0  0.326
1970 Shen FH, Loh HH, Way EL. Brain serotonin turnover in morphine tolerant and dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 175: 427-34. PMID 5529726  0.56
1969 Way EL, Loh HH, Shen FH. Simultaneous quantitative assessment of morphine tolerance and physical dependence. The Journal of Pharmacology and Experimental Therapeutics. 167: 1-8. PMID 5814495  0.546
1969 Loh HH, Shen FH, Way EL. Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide. Biochemical Pharmacology. 18: 2711-21. PMID 5408607 DOI: 10.1016/0006-2952(69)90179-8  0.65
1968 Way EL, Loh HH, Shen F. Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine. Science (New York, N.Y.). 162: 1290-2. PMID 5748987 DOI: 10.1126/Science.162.3859.1290  0.61
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