| Year |
Citation |
Score |
| 1997 |
Ohkawa S, DiGiacomo B, Larson DL, Takemori AE, Portoghese PS. 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. Journal of Medicinal Chemistry. 40: 1720-5. PMID 9171881 DOI: 10.1021/jm9700880 |
0.453 |
|
| 1997 |
Rady JJ, Baemmert D, Takemori AE, Portoghese PS, Fujimoto JM. Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss Webster mice. Pharmacology, Biochemistry, and Behavior. 56: 243-9. PMID 9050081 DOI: 10.1016/S0091-3057(96)00219-5 |
0.448 |
|
| 1996 |
Chang AC, Cowan A, Takemori AE, Portoghese PS. Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system. Journal of Medicinal Chemistry. 39: 4478-82. PMID 8893842 DOI: 10.1021/Jm960459X |
0.401 |
|
| 1996 |
Chang AC, Chao CC, Takemori AE, Gekker G, Hu S, Peterson PK, Portoghese PS. Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells. Journal of Medicinal Chemistry. 39: 1729-35. PMID 8648612 DOI: 10.1021/Jm950813B |
0.441 |
|
| 1996 |
Bolognesi ML, Ojala WH, Gleason WB, Griffin JF, Farouz-Grant F, Larson DL, Takemori AE, Portoghese PS. Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide "address" recognition at kappa opioid receptors. Journal of Medicinal Chemistry. 39: 1816-22. PMID 8627605 DOI: 10.1021/Jm950807F |
0.46 |
|
| 1995 |
Portoghese PS, Farouz-Grant F, Sultana M, Takemori AE. 7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice. Journal of Medicinal Chemistry. 38: 402-7. PMID 7853332 DOI: 10.1021/Jm00003A002 |
0.405 |
|
| 1995 |
Korlipara VL, Takemori AE, Portoghese PS. Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists. Journal of Medicinal Chemistry. 38: 1337-43. PMID 7731019 DOI: 10.1021/Jm00008A012 |
0.507 |
|
| 1995 |
Killian P, Holmes BB, Takemori AE, Portoghese PS, Fujimoto JM. Cold water swim stress- and delta-2 opioid-induced analgesia are modulated by spinal gamma-aminobutyric acidA receptors. The Journal of Pharmacology and Experimental Therapeutics. 274: 730-4. PMID 7636735 |
0.367 |
|
| 1994 |
Chang AC, Takemori AE, Portoghese PS. 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. Journal of Medicinal Chemistry. 37: 1547-9. PMID 8201586 DOI: 10.1021/Jm00037A001 |
0.493 |
|
| 1994 |
Portoghese PS, Lin CE, Farouz-Grant F, Takemori AE. Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor. Journal of Medicinal Chemistry. 37: 1495-500. PMID 8182708 DOI: 10.1021/Jm00036A015 |
0.365 |
|
| 1994 |
Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6 |
0.445 |
|
| 1994 |
Portoghese PS, Sultana M, Moe ST, Takemori AE. Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety. Journal of Medicinal Chemistry. 37: 579-85. PMID 8126697 DOI: 10.1021/Jm00031A006 |
0.444 |
|
| 1994 |
Rady JJ, Takemori AE, Portoghese PS, Fujimoto JM. Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice. Life Sciences. 55: 603-9. PMID 8046996 DOI: 10.1016/0024-3205(94)00486-2 |
0.444 |
|
| 1994 |
Miyamoto Y, Bowen WD, Portoghese PS, Takemori AE. Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice. The Journal of Pharmacology and Experimental Therapeutics. 270: 37-9. PMID 8035333 |
0.529 |
|
| 1994 |
Portoghese PS, Ohkawa S, Moe ST, Takemori AE. Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety. Journal of Medicinal Chemistry. 37: 1886-8. PMID 8021929 DOI: 10.1021/Jm00038A019 |
0.406 |
|
| 1994 |
Korlipara VL, Takemori AE, Portoghese PS. N-benzylnaltrindoles as long-acting delta-opioid receptor antagonists. Journal of Medicinal Chemistry. 37: 1882-5. PMID 8021928 DOI: 10.1021/Jm00038A018 |
0.479 |
|
| 1994 |
Chang AC, Takemori AE, Ojala WH, Gleason WB, Portoghese PS. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. Journal of Medicinal Chemistry. 37: 4490-8. PMID 7799399 DOI: 10.1021/Jm00052A008 |
0.523 |
|
| 1994 |
Chang AC, Takemori AE, Portoghese PS. DIPPA: An opioid receptor affinity label that produces selective and long-lasting κ antagonism in mice Regulatory Peptides. 54: 49-50. DOI: 10.1016/0167-0115(94)90383-2 |
0.537 |
|
| 1993 |
Mitch CH, Leander JD, Mendelsohn LG, Shaw WN, Wong DT, Cantrell BE, Johnson BG, Reel JK, Snoddy JD, Takemori AE. 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. Journal of Medicinal Chemistry. 36: 2842-50. PMID 8410999 DOI: 10.1021/Jm00072A002 |
0.421 |
|
| 1993 |
Takemori AE, Portoghese PS. The mixed antinociceptive agonist-antagonist activity of beta-endorphin(1-27) in mice. Life Sciences. 53: 1049-52. PMID 8396188 DOI: 10.1016/0024-3205(93)90257-4 |
0.406 |
|
| 1993 |
Portoghese PS, Moe ST, Takemori AE. A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. Journal of Medicinal Chemistry. 36: 2572-4. PMID 8394935 DOI: 10.1021/Jm00069A017 |
0.448 |
|
| 1993 |
Miyamoto Y, Portoghese PS, Takemori AE. Involvement of delta 2 opioid receptors in acute dependence on morphine in mice. The Journal of Pharmacology and Experimental Therapeutics. 265: 1325-7. PMID 8389861 |
0.431 |
|
| 1993 |
Negus SS, Henriksen SJ, Mattox A, Pasternak GW, Portoghese PS, Takemori AE, Weinger MB, Koob GF. Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats. The Journal of Pharmacology and Experimental Therapeutics. 265: 1245-52. PMID 8389859 |
0.455 |
|
| 1993 |
Miyamoto Y, Takemori AE. Sites of action of naloxone in precipitating withdrawal jumping in morphine-dependent mice: investigations by the ED50 value and CNS content of naloxone. Drug and Alcohol Dependence. 32: 163-7. PMID 8389690 DOI: 10.1016/0376-8716(93)80009-4 |
0.327 |
|
| 1993 |
Miyamoto Y, Portoghese PS, Takemori AE. Involvement of delta 2 opioid receptors in the development of morphine dependence in mice. The Journal of Pharmacology and Experimental Therapeutics. 264: 1141-5. PMID 8383738 |
0.532 |
|
| 1993 |
Sofuoglu M, Portoghese PS, Takemori AE. 7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord. Life Sciences. 52: 769-75. PMID 8383271 DOI: 10.1016/0024-3205(93)90240-4 |
0.459 |
|
| 1993 |
Miyamoto Y, Takemori AE. Relative involvement of supraspinal and spinal mu opioid receptors in morphine dependence in mice. Life Sciences. 52: 1039-44. PMID 8383266 DOI: 10.1016/0024-3205(93)90196-A |
0.438 |
|
| 1993 |
Wild KD, Carlisi VJ, Mosberg HI, Bowen WD, Portoghese PS, Sultana M, Takemori AE, Hruby VJ, Porreca F. Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. The Journal of Pharmacology and Experimental Therapeutics. 264: 831-8. PMID 8382281 |
0.372 |
|
| 1993 |
Olmsted SL, Takemori AE, Portoghese PS. A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists. Journal of Medicinal Chemistry. 36: 179-80. PMID 8380614 DOI: 10.1021/Jm00053A025 |
0.452 |
|
| 1993 |
Lin CE, Takemori AE, Portoghese PS. Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity. Journal of Medicinal Chemistry. 36: 2412-5. PMID 8360887 DOI: 10.1021/Jm00068A020 |
0.471 |
|
| 1993 |
Takemori AE, Portoghese PS. Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively. European Journal of Pharmacology. 242: 145-50. PMID 8253111 DOI: 10.1016/0014-2999(93)90074-R |
0.466 |
|
| 1993 |
Larson DL, Hua M, Takemori AE, Portoghese PS. Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine. Journal of Medicinal Chemistry. 36: 3669-73. PMID 8246236 DOI: 10.1021/Jm00075A023 |
0.308 |
|
| 1993 |
Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Hruby VJ, Mosberg HI, Porreca F. Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 449-55. PMID 8229774 |
0.522 |
|
| 1993 |
Takemori AE, Loh HH, Lee NM. Suppression by dynorphin A and [des-Tyr1]dynorphin A peptides of the expression of opiate withdrawal and tolerance in morphine-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 266: 121-4. PMID 8101214 |
0.376 |
|
| 1993 |
Miyamoto Y, Portoghese PS, Takemori AE. Effects of naltriben (NTB) on the development and expression of chronic dependence on morphine Nida Research Monograph Series. 361. |
0.371 |
|
| 1993 |
Porreca F, Mosberg H, Chang KJ, Takemori A, Comer S, Dykstra L. Pharmacology of multiple opioid delta receptors Nida Research Monograph Series. 430-436. |
0.456 |
|
| 1992 |
Takemori AE, Loh HH, Lee NM. Suppression by dynorphin A-(1-13) of the expression of opiate withdrawal and tolerance in mice. European Journal of Pharmacology. 221: 223-6. PMID 1358653 DOI: 10.1016/0014-2999(92)90705-9 |
0.449 |
|
| 1992 |
Song SH, Takemori AE. Modulation of acute morphine tolerance by corticotropin-releasing factor and dynorphin A in the mouse spinal cord. Life Sciences. 51: 107-11. PMID 1352026 DOI: 10.1016/0024-3205(92)90003-8 |
0.476 |
|
| 1992 |
Portoghese PS, Larson DL, Sultana M, Takemori AE. Opioid agonist and antagonist activities of morphindoles related to naltrindole. Journal of Medicinal Chemistry. 35: 4325-9. PMID 1333013 DOI: 10.1021/Jm00101A009 |
0.472 |
|
| 1992 |
Takemori AE. Opioid pharmacology a'la mode. Nida Research Monograph. 119: 21-6. PMID 1331795 |
0.322 |
|
| 1992 |
Portoghese PS, Sultana M, Nelson WL, Klein P, Takemori AE. Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes. Journal of Medicinal Chemistry. 35: 4086-91. PMID 1331455 DOI: 10.1021/Jm00100A014 |
0.408 |
|
| 1992 |
Porreca F, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI. Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 263: 147-52. PMID 1328602 |
0.538 |
|
| 1992 |
Portoghese PS, Sultana M, Nagase H, Takemori AE. A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. European Journal of Pharmacology. 218: 195-6. PMID 1327826 DOI: 10.1016/0014-2999(92)90167-3 |
0.419 |
|
| 1992 |
Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. The Journal of Pharmacology and Experimental Therapeutics. 262: 190-7. PMID 1320682 |
0.473 |
|
| 1992 |
Takemori AE, Portoghese PS. Selective naltrexone-derived opioid receptor antagonists. Annual Review of Pharmacology and Toxicology. 32: 239-69. PMID 1318671 DOI: 10.1146/Annurev.Pa.32.040192.001323 |
0.446 |
|
| 1992 |
Sofuoglu M, Portoghese PS, Takemori AE. Maintenance of acute morphine tolerance in mice by selective blockage of kappa opioid receptors with norbinaltorphimine. European Journal of Pharmacology. 210: 159-62. PMID 1318206 DOI: 10.1016/0014-2999(92)90666-R |
0.537 |
|
| 1992 |
Takemori AE, Sultana M, Nagase H, Portoghese PS. Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone. Life Sciences. 50: 1491-5. PMID 1315896 DOI: 10.1016/0024-3205(92)90138-F |
0.476 |
|
| 1992 |
Mattia A, Farmer SC, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Bowen WD, Porreca F. Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 260: 518-25. PMID 1310737 |
0.471 |
|
| 1991 |
Portoghese PS, Nagase H, MaloneyHuss KE, Lin CE, Takemori AE. Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole. Journal of Medicinal Chemistry. 34: 1715-20. PMID 1851846 DOI: 10.1021/Jm00109A027 |
0.438 |
|
| 1991 |
Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. The Journal of Pharmacology and Experimental Therapeutics. 257: 676-80. PMID 1851833 |
0.429 |
|
| 1991 |
Portoghese PS, Garzon-Aburbeh A, Nagase H, Lin CE, Takemori AE. Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine. Journal of Medicinal Chemistry. 34: 1292-6. PMID 1849995 DOI: 10.1021/Jm00108A008 |
0.398 |
|
| 1991 |
Song ZH, Takemori AE. Antagonism of morphine antinociception by intrathecally administered corticotropin-releasing factor in mice. The Journal of Pharmacology and Experimental Therapeutics. 256: 909-12. PMID 1848633 |
0.465 |
|
| 1991 |
Song ZH, Takemori AE. Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception. Life Sciences. 48: 1447-53. PMID 1672725 DOI: 10.1016/0024-3205(91)90181-A |
0.544 |
|
| 1991 |
Sofuoglu M, Portoghese PS, Takemori AE. Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes. Life Sciences. 49: PL153-6. PMID 1658509 DOI: 10.1016/0024-3205(91)90397-T |
0.388 |
|
| 1991 |
Abdelhamid EE, Takemori AE. Characteristics of mu and delta opioid binding sites in striatal slices of morphine-tolerant and -dependent mice. European Journal of Pharmacology. 198: 157-63. PMID 1650700 DOI: 10.1016/0014-2999(91)90615-W |
0.491 |
|
| 1991 |
Abdelhamid EE, Sultana M, Portoghese PS, Takemori AE. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. The Journal of Pharmacology and Experimental Therapeutics. 258: 299-303. PMID 1649297 |
0.514 |
|
| 1991 |
Roerig SC, Hoffman RG, Takemori AE, Wilcox GL, Fujimoto JM. Isobolographic analysis of analgesic interactions between intrathecally and intracerebroventricularly administered fentanyl, morphine and D-Ala2-D-Leu5-enkephalin in morphine-tolerant and nontolerant mice. The Journal of Pharmacology and Experimental Therapeutics. 257: 1091-9. PMID 1646321 |
0.489 |
|
| 1991 |
Jiang Q, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes. The Journal of Pharmacology and Experimental Therapeutics. 257: 1069-75. PMID 1646319 |
0.426 |
|
| 1990 |
Sofuoglu M, Takemori AE. Naloxone produces protracted tolerance in mice treated with a single dose of morphine. The Journal of Pharmacology and Experimental Therapeutics. 254: 836-40. PMID 2395115 |
0.317 |
|
| 1990 |
Song ZH, Takemori AE. Involvement of spinal kappa opioid receptors in the antinociception produced by intrathecally administered corticotropin-releasing factor in mice. The Journal of Pharmacology and Experimental Therapeutics. 254: 363-8. PMID 2166788 DOI: 10.1016/0014-2999(90)94590-T |
0.485 |
|
| 1990 |
Portoghese PS, Sultana M, Takemori AE. Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. Journal of Medicinal Chemistry. 33: 1714-20. PMID 2160538 DOI: 10.1021/Jm00168A028 |
0.425 |
|
| 1990 |
Portoghese PS, Sultana M, Takemori AE. Naltrindole 5'-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist. Journal of Medicinal Chemistry. 33: 1547-8. PMID 2160532 DOI: 10.1021/jm00168a004 |
0.444 |
|
| 1990 |
Quock RM, Best JA, Chen DC, Vaughn LK, Portoghese PS, Takemori AE. Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors. European Journal of Pharmacology. 175: 97-100. PMID 2157601 DOI: 10.1016/0014-2999(90)90158-3 |
0.366 |
|
| 1990 |
Song ZH, Barbas DP, Portoghese PS, Takemori AE. Isolation of kappa opioid receptor with an aminoethyl-nor-binaltorphimine (AE-norBNI) affinity column. Progress in Clinical and Biological Research. 328: 69-72. PMID 2154821 |
0.421 |
|
| 1990 |
Abdelhamid EE, Takemori AE. Enhanced affinity of mu-opioid receptors in morphine-dependent mice. Progress in Clinical and Biological Research. 328: 523-6. PMID 2154814 |
0.513 |
|
| 1990 |
Liao J, Liu K, Takemori A. A753 QUANTITATIVE ASSESSMENT OF THE ANTINOCICEPTIVE EFFECTS OF MIDAZOLAM, AMITRIPTYLINE AND CARBAMAZEPINE ALONE AND IN COMBINATION WITH MORPHINE IN MICE Anesthesiology. 73: NA-NA. DOI: 10.1097/00000542-199009001-00751 |
0.356 |
|
| 1990 |
Portoghese PS, Sultana M, Takemori AE. Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept [Erratum to document cited in CA112(25):235659s] Journal of Medicinal Chemistry. 33: 3229-3229. DOI: 10.1021/Jm00174A021 |
0.349 |
|
| 1990 |
Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of DSLET and DPDPE by novel delta opioid receptor antagonists European Journal of Pharmacology. 183: 2322. DOI: 10.1016/0014-2999(90)93879-U |
0.448 |
|
| 1990 |
Takemori AE, Sofuoglu M, Sultana M, Nagase H, Portoghese PS. Pharmacology of highly selective, non-peptide delta opioid receptor antagonists New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 277. |
0.372 |
|
| 1990 |
Larson DL, Sultana M, Takemori AE, Portoghese PS. Highly selective nonpeptide delta-opioid receptor agonists related to naltrindole New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 220. |
0.432 |
|
| 1990 |
Sofuoglu M, Takemori AE. Protracted opiate tolerance produced by naloxone in mice treated with a single dose of morphine New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 139-140. |
0.445 |
|
| 1989 |
Takemori AE, Portoghese PS. The use of mu opioid receptors in the mouse vas deferens for the study of opiate tolerance. European Journal of Pharmacology. 174: 267-71. PMID 2560981 DOI: 10.1016/0014-2999(89)90319-1 |
0.536 |
|
| 1989 |
Hong EK, Takemori AE. Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice. The Journal of Pharmacology and Experimental Therapeutics. 251: 594-8. PMID 2553928 |
0.498 |
|
| 1989 |
Ho BY, Takemori AE. Serotonergic involvement in the antinociceptive action of and the development of tolerance to the kappa-opioid receptor agonist, U-50, 488H. The Journal of Pharmacology and Experimental Therapeutics. 250: 508-14. PMID 2547935 |
0.311 |
|
| 1989 |
Werling LL, McMahon PN, Portoghese PS, Takemori AE, Cox BM. Selective opioid antagonist effects on opioid-induced inhibition of release of norepinephrine in guinea pig cortex. Neuropharmacology. 28: 103-7. PMID 2541364 DOI: 10.1016/0028-3908(89)90044-0 |
0.446 |
|
| 1989 |
Tortella FC, Echevarria E, Lipkowski AW, Takemori AE, Portoghese PS, Holaday JW. Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model. Life Sciences. 44: 661-5. PMID 2538689 DOI: 10.1016/0024-3205(89)90470-0 |
0.463 |
|
| 1989 |
Botros S, Lipkowski AW, Larson DL, Stark PA, Takemori AE, Portoghese PS. Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine. Journal of Medicinal Chemistry. 32: 2068-71. PMID 2475628 DOI: 10.1021/jm00129a009 |
0.417 |
|
| 1988 |
Takahashi M, Portoghese PS, Takemori AE. Irreversible binding of [3H]beta-funaltrexamine to brain slices of morphine-tolerant and -dependent mice. European Journal of Pharmacology. 149: 205-12. PMID 3409950 DOI: 10.1016/0014-2999(88)90650-4 |
0.434 |
|
| 1988 |
Takemori AE, Schwartz MM, Portoghese PS. Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats. The Journal of Pharmacology and Experimental Therapeutics. 247: 971-4. PMID 2849679 |
0.421 |
|
| 1988 |
Takemori AE, Ho BY, Naeseth JS, Portoghese PS. Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. The Journal of Pharmacology and Experimental Therapeutics. 246: 255-8. PMID 2839664 |
0.48 |
|
| 1988 |
Portoghese PS, Nagase H, Takemori AE. Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine. Journal of Medicinal Chemistry. 31: 1344-7. PMID 2838632 DOI: 10.1021/Jm00402A015 |
0.433 |
|
| 1988 |
Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE. Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity. Journal of Medicinal Chemistry. 31: 836-41. PMID 2832604 DOI: 10.1021/Jm00399A026 |
0.414 |
|
| 1988 |
Portoghese PS, Sultana M, Takemori AE. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. European Journal of Pharmacology. 146: 185-6. PMID 2832195 DOI: 10.1016/0014-2999(88)90502-X |
0.374 |
|
| 1988 |
Portoghese PS, Sultana M, Nagase H, Takemori AE. Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists. Journal of Medicinal Chemistry. 31: 281-2. PMID 2828619 DOI: 10.1021/Jm00397A001 |
0.344 |
|
| 1988 |
Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE. Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity [Erratum to document cited in CA108(17):150771q] Journal of Medicinal Chemistry. 31: 2056-2056. DOI: 10.1021/Jm00118A035 |
0.334 |
|
| 1987 |
Martin JR, Takemori AE. Further evidence that a single dose of an opiate can increase dopamine receptor sensitivity in mice. European Journal of Pharmacology. 135: 203-9. PMID 3582494 DOI: 10.1016/0014-2999(87)90612-1 |
0.433 |
|
| 1987 |
Martin JR, Takemori AE. Modification of the development of acute opiate tolerance by increased dopamine receptor sensitivity. The Journal of Pharmacology and Experimental Therapeutics. 241: 48-55. PMID 3572795 |
0.506 |
|
| 1987 |
Schoenecker JW, Takemori AE, Portoghese PS. Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives. Journal of Medicinal Chemistry. 30: 1040-4. PMID 3035177 DOI: 10.1021/Jm00389A014 |
0.322 |
|
| 1987 |
Schoenecker JW, Takemori AE, Portoghese PS. Opioid agonist and antagonist activities of monofunctional nitrogen mustard analogues of beta-chlornaltrexamine. Journal of Medicinal Chemistry. 30: 933-5. PMID 3033246 DOI: 10.1021/Jm00388A033 |
0.341 |
|
| 1987 |
Portoghese AS, Lipkowski AW, Takemori AE. Bimorphinans as highly selective, potent kappa opioid receptor antagonists. Journal of Medicinal Chemistry. 30: 238-9. PMID 3027336 DOI: 10.1021/Jm00385A002 |
0.443 |
|
| 1987 |
Portoghese PS, Lipkowski AW, Takemori AE. Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sciences. 40: 1287-92. PMID 2882399 DOI: 10.1016/0024-3205(87)90585-6 |
0.468 |
|
| 1987 |
Takemori AE, Portoghese PS. Evidence for the interaction of morphine with kappa and delta opioid receptors to induce analgesia in beta-funaltrexamine-treated mice. The Journal of Pharmacology and Experimental Therapeutics. 243: 91-4. PMID 2822908 |
0.499 |
|
| 1987 |
Portoghese PS, Larson DL, Ronsisvalle G, Schiller PW, Nguyen TM, Lemieux C, Takemori AE. Hybrid bivalent ligands with opiate and enkephalin pharmacophores. Journal of Medicinal Chemistry. 30: 1991-4. PMID 2444704 DOI: 10.1021/Jm00394A010 |
0.387 |
|
| 1987 |
SCHOENECKER JW, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Opioid Agonist and Antagonist Activities of Monofunctional Nitrogen Mustard Analogues (I) of β-Chlornaltrexamine. Cheminform. 18. DOI: 10.1002/chin.198746353 |
0.381 |
|
| 1987 |
PORTOGHESE PS, LARSON DL, SAYRE LM, YIM CB, RONSISVALLE G, TAM SW, TAKEMORI AE. ChemInform Abstract: Opioid Agonist and Antagonist Bivalent Ligands. The Relationship between Spacer Length and Selectivity at Multiple Opioid Receptors. Cheminform. 18. DOI: 10.1002/chin.198711343 |
0.453 |
|
| 1987 |
SCHOENECKER JW, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Irreversible Blockage of Opioid Receptor Types by Ester Homologues of β-Funaltrexamine. Cheminform. 18. DOI: 10.1002/chin.198711313 |
0.353 |
|
| 1987 |
PORTOGHESE PS, RONSISVALLE G, LARSON DL, TAKEMORI AE. ChemInform Abstract: Synthesis and Opioid Antagonist Potencies of Naltrexamine Bivalent Ligands with Conformationally Restricted Spacers. Cheminform. 18. DOI: 10.1002/chin.198706307 |
0.405 |
|
| 1987 |
MOHAMED MS, LARSON DL, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Activity of N-Methyl-α- and -β-funaltrexamine at Opioid Receptors. Cheminform. 18. DOI: 10.1002/chin.198704313 |
0.313 |
|
| 1986 |
Aceto MD, Dewey WL, Portoghese PS, Takemori AE. Effects of beta-funaltrexamine (beta-FNA) on morphine dependence in rats and monkeys. European Journal of Pharmacology. 123: 387-93. PMID 3720824 DOI: 10.1016/0014-2999(86)90713-2 |
0.438 |
|
| 1986 |
Martin JR, Takemori AE. Chronically administered morphine increases dopamine receptor sensitivity in mice. European Journal of Pharmacology. 121: 221-9. PMID 3699094 DOI: 10.1016/0014-2999(86)90493-0 |
0.423 |
|
| 1986 |
Portoghese PS, Takemori AE. Affinity labels as probes for opioid receptor types and subtypes. Nida Research Monograph. 69: 157-68. PMID 3020413 |
0.392 |
|
| 1986 |
Schoenecker JW, Takemori AE, Portoghese PS. Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. Journal of Medicinal Chemistry. 29: 1868-71. PMID 3020246 DOI: 10.1021/Jm00160A013 |
0.516 |
|
| 1986 |
Portoghese PS, Rein MD, Takemori AE. Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors. Journal of Medicinal Chemistry. 29: 1861-4. PMID 3020245 DOI: 10.1021/Jm00160A011 |
0.457 |
|
| 1986 |
Portoghese PS, Larson DL, Sayre LM, Yim CB, Ronsisvalle G, Tam SW, Takemori AE. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors. Journal of Medicinal Chemistry. 29: 1855-61. PMID 3020244 DOI: 10.1021/Jm00160A010 |
0.525 |
|
| 1986 |
Portoghese PS, Ronsisvalle G, Larson DL, Takemori AE. Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers. Journal of Medicinal Chemistry. 29: 1650-3. PMID 3018242 DOI: 10.1021/Jm00159A014 |
0.546 |
|
| 1986 |
Mohamed MS, Larson DL, Takemori AE, Portoghese PS. Activity of N-methyl-alpha- and -beta-funaltrexamine at opioid receptors. Journal of Medicinal Chemistry. 29: 1551-3. PMID 3016272 DOI: 10.1021/Jm00158A043 |
0.441 |
|
| 1986 |
Takemori AE, Ikeda M, Portoghese PS. The mu, kappa and delta properties of various opioid agonists. European Journal of Pharmacology. 123: 357-61. PMID 3013652 DOI: 10.1016/0014-2999(86)90709-0 |
0.473 |
|
| 1986 |
Botros S, Lipkowski AW, Takemori AE, Portoghese PS. Investigation of the structural requirements for the kappa-selective opioid receptor antagonist, 6 beta,6 beta'-[ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)- 4,5 alpha-epoxymorphinan-3,14-diol] (TENA). Journal of Medicinal Chemistry. 29: 874-6. PMID 3009817 DOI: 10.1021/Jm00155A048 |
0.415 |
|
| 1986 |
Ahlijanian MK, Takemori AE. Changes in adenosine receptor sensitivity in morphine-tolerant and -dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 236: 615-20. PMID 3005548 |
0.721 |
|
| 1986 |
Ahlijanian MK, Takemori AE. The effect of chronic administration of caffeine on morphine-induced analgesia, tolerance and dependence in mice. European Journal of Pharmacology. 120: 25-32. PMID 3005000 DOI: 10.1016/0014-2999(86)90635-7 |
0.725 |
|
| 1986 |
Ahlijanian MK, Takemori AE. Cross-tolerance studies between caffeine and (-)-N6-(phenylisopropyl)-adenosine (PIA) in mice. Life Sciences. 38: 577-88. PMID 3003486 DOI: 10.1016/0024-3205(86)90051-2 |
0.653 |
|
| 1986 |
Ahlijanian MK, Takemori AE. Effects of caffeine and 8-phenyltheophylline on the actions of purines and opiates in the guinea-pig ileum. The Journal of Pharmacology and Experimental Therapeutics. 236: 171-6. PMID 3001283 |
0.68 |
|
| 1986 |
BOTROS S, LIPKOWSKI AW, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Investigation of the Structural Requirements for the K-Selective Opioid Receptor Antagonist, 6β,6β′-[Ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)-4,5-epoxymorphinan-3,14-diol] (TENA). Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198638302 |
0.333 |
|
| 1985 |
Martin JR, Takemori AE. Increased sensitivity to dopamine agonists following a single dose of morphine or levorphanol in mice. European Journal of Pharmacology. 119: 75-84. PMID 3002820 DOI: 10.1016/0014-2999(85)90324-3 |
0.413 |
|
| 1985 |
Takemori AE, Portoghese PS. Receptors for opioid peptides in the guinea-pig ileum. The Journal of Pharmacology and Experimental Therapeutics. 235: 389-92. PMID 2997432 |
0.341 |
|
| 1985 |
Takemori AE, Portoghese PS. Selectivity of opioid agonists and antagonists for the various opioid receptor types. Psychopharmacology Bulletin. 21: 464-5. PMID 2994158 |
0.467 |
|
| 1985 |
Portoghese PS, Larson DL, Yim CB, Sayre LM, Ronsisvalle G, Lipkowski AW, Takemori AE, Rice KC, Tam SW. Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors. Journal of Medicinal Chemistry. 28: 1140-1. PMID 2993609 DOI: 10.1002/Chin.198551348 |
0.534 |
|
| 1985 |
Ahlijanian MK, Takemori AE. Effects of (-)-N6-(R-phenylisopropyl)-adenosine (PIA) and caffeine on nociception and morphine-induced analgesia, tolerance and dependence in mice. European Journal of Pharmacology. 112: 171-9. PMID 2992993 DOI: 10.1016/0014-2999(85)90493-5 |
0.727 |
|
| 1985 |
Takemori AE, Portoghese PS. Affinity labels for opioid receptors. Annual Review of Pharmacology and Toxicology. 25: 193-223. PMID 2988419 DOI: 10.1146/Annurev.Pa.25.040185.001205 |
0.409 |
|
| 1985 |
Portoghese PS, Takemori AE. TENA, a selective kappa opioid receptor antagonist. Life Sciences. 36: 801-5. PMID 2983171 DOI: 10.1016/0024-3205(85)90202-4 |
0.484 |
|
| 1985 |
PORTOGHESE PS, LARSON DL, YIM CB, SAYRE LM, RONSISVALLE G, LIPKOWSKI AW, TAKEMORI AE, RICE KC, TAM SW. ChemInform Abstract: STEREOSTRUCTURE-ACTIVITY RELATIONSHIP OF OPIOID AGONIST AND ANTAGONIST BIVALENT LIGANDS. EVIDENCE FOR BRIDGING BETWEEN VICINAL OPIOID RECEPTORS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198551348 |
0.453 |
|
| 1985 |
FANG S, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: ACTIVITIES OF MORPHINONE AND N-(CYCLOPROPYLMETHYL)NORMORPHINONE AT OPIOID RECEPTORS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198509358 |
0.441 |
|
| 1985 |
SAYRE LM, LARSON DL, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: DESIGN AND SYNTHESIS OF NALTREXONE-DERIVED AFFINITY LABELS WITH NONEQUILIBRIUM OPIOID AGONIST AND ANTAGONIST ACTIVITIES. EVIDENCE FOR THE EXISTENCE OF DIFFERENT μ RECEPTOR SUBTYPES IN DIFFERENT TISSUES Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198509357 |
0.392 |
|
| 1985 |
Takemori AE, Portoghese PS. β-FNA-insensitive, opioid peptide preferring receptors in the guinea pig ileum (GPI) Federation Proceedings. 44: No. 5459. |
0.317 |
|
| 1984 |
Contreras PC, Takemori AE. Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone. The Journal of Pharmacology and Experimental Therapeutics. 229: 21-6. PMID 6323687 |
0.393 |
|
| 1984 |
Fang S, Takemori AE, Portoghese PS. Activities of morphinone and N-(cyclopropylmethyl)normorphinone at opioid receptors. Journal of Medicinal Chemistry. 27: 1361-3. PMID 6207298 DOI: 10.1002/Chin.198509358 |
0.38 |
|
| 1984 |
Contreras PC, Takemori AE. Dose-dependent effects of prolyl-leucyl-glycinamide on morphine-induced analgesia, tolerance and dependence. European Journal of Pharmacology. 102: 13-22. PMID 6148243 DOI: 10.1016/0014-2999(84)90332-7 |
0.554 |
|
| 1984 |
Contreras PC, Takemori AE. Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence. Life Sciences. 34: 2559-66. PMID 6146083 DOI: 10.1016/0024-3205(84)90041-9 |
0.321 |
|
| 1984 |
Takemori AE, Portoghese PS. Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists. European Journal of Pharmacology. 104: 101-4. PMID 6094203 DOI: 10.1016/0014-2999(84)90374-1 |
0.504 |
|
| 1984 |
DeLander GE, Portoghese PS, Takemori AE. Role of spinal mu opioid receptors in the development of morphine tolerance and dependence. The Journal of Pharmacology and Experimental Therapeutics. 231: 91-6. PMID 6092607 |
0.471 |
|
| 1984 |
Sayre LM, Larson DL, Takemori AE, Portoghese PS. Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues. Journal of Medicinal Chemistry. 27: 1325-35. PMID 6090663 DOI: 10.1002/Chin.198509357 |
0.417 |
|
| 1984 |
PORTOGHESE PS, TAKEMORI AE. ChemInform Abstract: DIFFERENT RECEPTOR SITES MEDIATE OPIOID AGONISM AND ANTAGONISM Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198413357 |
0.417 |
|
| 1984 |
SAYRE LM, LARSON DL, FRIES DS, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: IMPORTANCE OF CARBON 6 CHIRALITY IN CONFERRING IRREVERSIBLE OPIOID ANTAGONISM TO NALTREXONE-DERIVED AFFINITY LABELS Chemischer Informationsdienst. 15. DOI: 10.1002/Chin.198406322 |
0.328 |
|
| 1984 |
DeLander GE, Takemori AE. Spinal serotonergic pathways in the expression of tolerance to morphine (M) analgesia Federation Proceedings. 43: no. 3990. |
0.307 |
|
| 1984 |
Ahlijanian MK, Takemori AE. Effects of caffeine (C) and (-)-N6 (R-phenyl-isopropyl-adenosine) (PIA) on expression of morphine (M) dependence and cross tolerance to morphine Federation Proceedings. 43: No. 3807. |
0.693 |
|
| 1983 |
Delander GE, Takemori AE. Spinal antagonism of tolerance and dependence induced by systemically administered morphine. European Journal of Pharmacology. 94: 35-42. PMID 6686142 DOI: 10.1016/0014-2999(83)90439-9 |
0.424 |
|
| 1983 |
Oishi R, Ozaki M, Takemori AE. In vivo binding of naloxone to opioid receptors in morphine-dependent mice. Neuropharmacology. 22: 1015-9. PMID 6312358 DOI: 10.1016/0028-3908(83)90218-6 |
0.465 |
|
| 1983 |
Portoghese PS, Takemori AE. Different receptor sites mediate opioid agonism and antagonism. Journal of Medicinal Chemistry. 26: 1341-3. PMID 6312042 DOI: 10.1002/Chin.198413357 |
0.505 |
|
| 1983 |
Sayre LM, Larson DL, Fries DS, Takemori AE, Portoghese PS. Importance of C-6 chirality in conferring irreversible opioid antagonism to naltrexone-derived affinity labels. Journal of Medicinal Chemistry. 26: 1229-35. PMID 6310111 DOI: 10.1021/Jm00363A005 |
0.373 |
|
| 1983 |
Sayre LM, Portoghese PS, Takemori AE. Difference between mu-receptors in the guinea pig ileum and the mouse vas deferens. European Journal of Pharmacology. 90: 159-60. PMID 6307720 DOI: 10.1016/0014-2999(83)90232-7 |
0.341 |
|
| 1983 |
Ward SJ, Takemori AE. Determination of the relative involvement of mu-opioid receptors in opioid-induced depression of respiratory rate by use of beta-funaltrexamine. European Journal of Pharmacology. 87: 1-6. PMID 6301847 DOI: 10.1016/0014-2999(83)90043-2 |
0.348 |
|
| 1983 |
Sayre LM, Takemori AE, Portoghese PS. Alkylation of opioid receptor subtypes by alpha-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities. Journal of Medicinal Chemistry. 26: 503-6. PMID 6300401 DOI: 10.1021/Jm00358A009 |
0.365 |
|
| 1983 |
Ward SJ, Takemori AE. Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice. The Journal of Pharmacology and Experimental Therapeutics. 224: 359-63. PMID 6296358 |
0.42 |
|
| 1983 |
Ward SJ, Takemori AE. Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 224: 525-30. PMID 6131119 |
0.467 |
|
| 1983 |
SAYRE LM, TAKEMORI AE, PROTOGHESE PS. ChemInform Abstract: Alkylation of Opioid Receptor Subtypes by α-Chlornaltrexamine Produces Concurrent irreversible Agonistic and irreversible Antagonistic Activities. Stereochemical Studies on Medicinal Agents. Part 27. Chemischer Informationsdienst. 14. DOI: 10.1002/CHIN.198334345 |
0.384 |
|
| 1983 |
Ahlijanian MK, Takemori AE. Potentiation by 1-N6-phenylisopropyladenosine (1-PIA) of morphine (M)-induced analgesia, tolerance and dependence Federation Proceedings. 42: No. 324. |
0.688 |
|
| 1983 |
Contreras PC, Takemori AE. Dose-dependent interactions between prolyl-leucyl-glycinamide and morphine Federation Proceedings. 42: No. 322. |
0.393 |
|
| 1982 |
Erez M, Takemori AE, Portoghese PS. Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites. Journal of Medicinal Chemistry. 25: 847-9. PMID 7108900 DOI: 10.1021/Jm00349A016 |
0.387 |
|
| 1982 |
Ward SJ, Portoghese PS, Takemori AE. Improved assays for the assessment of kappa- and delta-properties of opioid ligands. European Journal of Pharmacology. 85: 163-70. PMID 6295778 DOI: 10.1016/0014-2999(82)90461-7 |
0.44 |
|
| 1982 |
Portoghese PS, Ronsisvalle G, Larson DL, Yim CB, Sayre LM, Takemori AE. Opioid agonist and antagonist bivalent ligands as receptor probes. Life Sciences. 31: 1283-6. PMID 6292615 DOI: 10.1016/0024-3205(82)90362-9 |
0.454 |
|
| 1982 |
Messing RB, Portoghese PS, Takemori AE, Sparber SB. Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators. Pharmacology, Biochemistry, and Behavior. 16: 621-6. PMID 6280206 DOI: 10.1016/0091-3057(82)90426-9 |
0.45 |
|
| 1982 |
Oishi R, Takemori AE. Stereospecific accumulation of dihydromorphine and naltrexone by corpus striatal slices of morphine-dependent mice. Neuropharmacology. 21: 57-61. PMID 6278352 DOI: 10.1016/0028-3908(82)90211-8 |
0.425 |
|
| 1982 |
Ward SJ, Takemori AE. Relative involvement of receptor subtypes in opioid-induced inhibition of intestinal motility in mice. Life Sciences. 31: 1267-70. PMID 6128653 DOI: 10.1016/0024-3205(82)90358-7 |
0.368 |
|
| 1982 |
Delander GE, Takemori AE. Spinal μ-opiate receptor blockade inhibits tolerance to morphine analgesia Federation Proceedings. 41: No. 4522. |
0.438 |
|
| 1982 |
Contreras PC, Takemori AE. The effect of α-melanocyte stimulating hormone (MSH) on morphine analgesia, tolerance and dependence Federation Proceedings. 41: No. 5544. |
0.368 |
|
| 1981 |
Tulunay FC, Ayhan IH, Portoghese PS, Takemori AE. Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats. European Journal of Pharmacology. 70: 219-24. PMID 6266844 DOI: 10.1016/0014-2999(81)90217-X |
0.413 |
|
| 1981 |
Vaught JL, Kitano T, Takemori AE. Interactions of leucine enkephalin and narcotics with opioid receptors. Molecular Pharmacology. 19: 236-41. PMID 6262617 |
0.429 |
|
| 1981 |
Contreras PC, Takemori AE. Facilitation of morphine-induced tolerance and physical dependence by prolyl-leucyl-glycinamide. European Journal of Pharmacology. 71: 259-68. PMID 6113968 DOI: 10.1016/0014-2999(81)90028-5 |
0.5 |
|
| 1980 |
Dwoskin LP, Sprague GL, Takemori AE, Sparber SB. Morphine release and displacement by naloxone in vivo in morphine naive and withdrawn rats. Life Sciences. 26: 377-85. PMID 7189229 DOI: 10.1016/0024-3205(80)90154-X |
0.448 |
|
| 1980 |
Larson AA, Vaught JL, Takemori AE. The potentiation of spinal analgesia by leucine enkephalin. European Journal of Pharmacology. 61: 381-3. PMID 6892802 DOI: 10.1016/0014-2999(80)90077-1 |
0.653 |
|
| 1980 |
Yano I, Sparber SB, Takemori AE. Alterations in morphine-induced analgesia and tolerance by various compounds. Substance and Alcohol Actions/Misuse. 1: 145-50. PMID 6272431 |
0.415 |
|
| 1980 |
Portoghese PS, Larson DL, Sayre LM, Fries DS, Takemori AE. A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. Journal of Medicinal Chemistry. 23: 233-4. PMID 6245210 DOI: 10.1021/Jm00177A002 |
0.403 |
|
| 1980 |
Caruso TP, Larson DL, Portoghese PS, Takemori AE. Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine. The Journal of Pharmacology and Experimental Therapeutics. 213: 539-44. PMID 6162947 |
0.5 |
|
| 1980 |
Contreras PC, Takemori AE. The effects of prolyl-leucyl-glycinamide on morphine tolerance and dependence Federation Proceedings. 39: 3048. |
0.495 |
|
| 1980 |
Oishi R, Takemori AE. Alteration in stereospecific uptake of dihydromorphine (DHM) and naltrexone (NTX) by striatal slices of morphine tolerant-dependent mice Pharmacologist. 22: 406. |
0.431 |
|
| 1979 |
Tulunay FC, Yano I, Takemori AE. Enhanced naloxone potency and the development of narcotic tolerance. European Journal of Pharmacology. 53: 247-53. PMID 759202 DOI: 10.1016/0014-2999(79)90130-4 |
0.426 |
|
| 1979 |
Vaught JL, Takemori AE. Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence. The Journal of Pharmacology and Experimental Therapeutics. 208: 86-90. PMID 569699 |
0.517 |
|
| 1979 |
Vaught JL, Takemori AE. A further characterization of the differential effects of leucine enkephalin, methionine enkephalin and their analogs on morphine-induced analgesia. The Journal of Pharmacology and Experimental Therapeutics. 211: 280-3. PMID 501561 |
0.464 |
|
| 1979 |
Kitano T, Takemori AE. Further studies on the enhanced affinity of opioid receptors for naloxone in morphine-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 209: 456-61. PMID 220409 |
0.518 |
|
| 1979 |
Portoghese PS, Larson DL, Jiang JB, Caruso TP, Takemori AE. Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties. Journal of Medicinal Chemistry. 22: 168-73. PMID 218009 DOI: 10.1002/Chin.197925340 |
0.519 |
|
| 1979 |
Caruso TP, Takemori AE, Larson DL, Portoghese PS. Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity. Science (New York, N.Y.). 204: 316-8. PMID 86208 DOI: 10.1126/Science.86208 |
0.425 |
|
| 1979 |
McGilliard KL, Takemori AE. The effect of dopaminergic modifiers on morphine-induced analgesia and respiratory depression. European Journal of Pharmacology. 54: 61-8. PMID 33817 DOI: 10.1016/0014-2999(79)90408-4 |
0.405 |
|
| 1979 |
Caruso TP, Takemori AE, Larson DL, Portoghese PS. Ultralong lasting single-dose tolerance to chloroxymorphamine (COA), an opioid receptor alkylating agonist Federation Proceedings. 38: No. 1894. |
0.472 |
|
| 1979 |
Vaught JL, Kitano T, Takemori AE. Facilitation of narcotic-induced enhancement of naloxone efficacy by leu-enkephalin Federation Proceedings. 38: No. 713. |
0.316 |
|
| 1978 |
McGilliard KL, Takemori AE. Alterations in the antagonism by naloxone of morphine-induced respiratory depression and analgesia after morphine pretreatment. The Journal of Pharmacology and Experimental Therapeutics. 207: 884-91. PMID 731438 |
0.459 |
|
| 1978 |
Sprague GL, Takemori AE. Enhancement of morphine analgesia and brain levels by methamphetamine in mice Journal of Pharmacology and Experimental Therapeutics. 207: 485-493. PMID 712632 |
0.486 |
|
| 1978 |
Vaught JL, Takemori AE. Characterization of leucine and methionine enkephalin and their interaction with morphine on the guinea pig ileal longitudinal muscle. Research Communications in Chemical Pathology and Pharmacology. 21: 391-407. PMID 705020 |
0.481 |
|
| 1978 |
Sprague GL, Takemori AE. Effect of methamphetamine on the development of acute morphine tolerance and dependence in mice. Life Sciences. 23: 2491-8. PMID 569751 DOI: 10.1016/0024-3205(78)90173-X |
0.413 |
|
| 1978 |
Larson AA, Takemori AE. Effect of morphine on the fate of newly transported tryptophan and 5-hydroxytryptophan in brain of rats. The Journal of Pharmacology and Experimental Therapeutics. 205: 265-73. PMID 305957 |
0.567 |
|
| 1978 |
Portoghese PS, Larson DL, Jiang JB, Takemori AE, Caruso TP. 6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty. Journal of Medicinal Chemistry. 21: 598-9. PMID 209185 DOI: 10.1021/Jm00205A002 |
0.346 |
|
| 1978 |
McGilliard KL, Takemori AE. Antagonism by naloxone of narcotic-induced respiratory depression and analgesia. The Journal of Pharmacology and Experimental Therapeutics. 207: 494-503. PMID 30841 |
0.411 |
|
| 1978 |
Takemori AE, Sprague GL. Comparison of naloxone-induced platform vertical jumping in the assessment of physical dependence in morphine-dependent mice. The Journal of Pharmacy and Pharmacology. 30: 585-6. PMID 29102 |
0.402 |
|
| 1978 |
Portoghese P, Larson D, Jiang J, Takemori A, Caruso T. Additions and Corrections - 6β[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan(Chlornaltrexamine), a Potent Opioid Receptor Alkylating Agent with Ultralong Narcotic Antagonist Activity Journal of Medicinal Chemistry. 21: 1340-1340. DOI: 10.1021/Jm00210A602 |
0.329 |
|
| 1978 |
PORTOGHESE PS, LARSON DL, JIANG JB, TAKEMORI AE, CARUSO TP. ChemInform Abstract: 6β-(N,N-BIS(2-CHLOROETHYL)AMINO)-17-(CYCLOPROPYLMETHYL)-4,5α-EPOXY-3# ,14-DIHYDROXYMORPHINAN (CHLORANALTREXAMINE), A POTENT OPIOID RECEPTOR ALKYLATING AGENT WITH ULTRALONG NARCOTIC ANTAGONIST ACTIVITY Chemischer Informationsdienst. 9. DOI: 10.1002/Chin.197850350 |
0.328 |
|
| 1978 |
Dwoskin LP, Sprague GL, Takemori AE, Sparber SB. Differential displacement of 3H-morphine by naloxone in vivo between naive and morphine-withdrawn rats Pharmacologist. 20: 124. |
0.451 |
|
| 1978 |
Vaught JL, Takemori AE. Differential effects of leu- and met-enkephalin on morphine-induced analgesia, tolerance and dependence Pharmacologist. 20: 116. |
0.475 |
|
| 1977 |
Jiang JB, Hanson RN, Portoghese PS, Takemori AE. Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone. Journal of Medicinal Chemistry. 20: 1100-2. PMID 894682 DOI: 10.1002/Chin.197749253 |
0.393 |
|
| 1977 |
Larson AA, Takemori AE. Effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake, on morphine analgesia and the development of tolerance. Life Sciences. 21: 1807-11. PMID 604708 DOI: 10.1016/0024-3205(77)90162-X |
0.668 |
|
| 1977 |
Larson AA, Takemori AE. Effect of narcotics on the uptake of serotonin precursors by the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 200: 216-23. PMID 299890 |
0.592 |
|
| 1977 |
Kitano T, Takemori AE. Enhanced affinity of opiate receptors for naloxone in striatal slices of morphine-dependent mice. Research Communications in Chemical Pathology and Pharmacology. 18: 341-51. PMID 199923 |
0.497 |
|
| 1977 |
Portoghese PS, Hanson RN, Telang VG, Winger JL, Takemori AE. 3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents. Journal of Medicinal Chemistry. 20: 1020-4. PMID 197237 DOI: 10.1002/Chin.197749376 |
0.443 |
|
| 1977 |
Yano I, Takemori AE. Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine. Research Communications in Chemical Pathology and Pharmacology. 16: 721-34. PMID 16322 |
0.404 |
|
| 1976 |
Tulunay FC, Yano I, Takemori AE. The effect of biogenic amine modifiers on morphine analgesia and its antagonism by naloxone. European Journal of Pharmacology. 35: 285-92. PMID 1248505 |
0.51 |
|
| 1976 |
Ward A, Takemori AE. Effect of 6-hydroxydopamine and 5,6-dihydroxytryptamine on the response of the coaxially stimulated guinea-pig ileum to morphine. The Journal of Pharmacology and Experimental Therapeutics. 199: 124-30. PMID 978474 |
0.366 |
|
| 1976 |
Spaulding TC, Kotake AN, Takemori AE. Microsomal spectral properties and narcotic N-demethylase activity in methadone-dependent rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 4: 45-52. PMID 3401 |
0.347 |
|
| 1975 |
Takemori AE, Tulunay FC, Yano I. Differential effects on morphine analgesia and naloxone antagonism by biogenic amine modifiers. Life Sciences. 17: 21-7. PMID 1143009 |
0.48 |
|
| 1974 |
Takemori AE, Ward A, Portoghese PS, Telang VG. Potential nonequilibrium analgetic receptor inactivators. Further pharmacologic studies of N-acylanileridines. Journal of Medicinal Chemistry. 17: 1051-4. PMID 4479531 DOI: 10.1002/Chin.197505281 |
0.363 |
|
| 1974 |
Tulunay FC, Takemori AE. The increased efficacy of narcotic antagonists induced by various narcotic analgesics. The Journal of Pharmacology and Experimental Therapeutics. 190: 395-400. PMID 4416308 |
0.309 |
|
| 1974 |
Takemori AE, Stesin AJ, Tulunay FC. A single-dose suppression test in morphine-dependent mice. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 145: 1232-5. PMID 4406488 |
0.378 |
|
| 1974 |
Tulunay FC, Takemori AE. Further studies on the alteration of analgesic receptor-antagonist interaction induced by morphine. The Journal of Pharmacology and Experimental Therapeutics. 190: 401-7. PMID 4153360 |
0.47 |
|
| 1973 |
Takemori AE. Determination of pharmacological constants: use of narcotic antagonists to characterize analgesic receptors. Advances in Biochemical Psychopharmacology. 8: 335-44. PMID 4794904 |
0.304 |
|
| 1973 |
Maruyama Y, Takemori AE. The role of dopamine and norepinephrine in the naloxone-induced abstinence of morphine-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 185: 602-8. PMID 4736512 |
0.369 |
|
| 1973 |
Takemori AE, Oka T, Nishiyama N. Alteration of analgesic receptor-antagonist interaction induced by morphine. The Journal of Pharmacology and Experimental Therapeutics. 186: 261-5. PMID 4719780 |
0.469 |
|
| 1972 |
Dodge PW, Takemori AE. Effects of morphine, nalorphine and pentobarbital alone and in combination on cerebral glycolytic substrates and cofactors of rats in vivo. Biochemical Pharmacology. 21: 287-94. PMID 5014487 |
0.355 |
|
| 1972 |
Takemori AE, Hayashi G, Smits SE. Studies on the quantitative antagonism of analgesics by naloxone and diprenorphine. European Journal of Pharmacology. 20: 85-92. PMID 4637947 |
0.456 |
|
| 1971 |
Craig AL, O'Dea RF, Takemori AE. The uptake of morphine by the choroid plexus and cerebral cortical slices of animals chronically treated with morphine. Neuropharmacology. 10: 709-14. PMID 5128026 |
0.389 |
|
| 1971 |
Portoghese PS, Telang VG, Takemori AE, Hayashi G. Potential nonequilibrium analgetic receptor inactivators. Synthesis and biological activities of N-acylanileridines. Journal of Medicinal Chemistry. 14: 144-8. PMID 5107751 DOI: 10.1021/Jm00284A015 |
0.326 |
|
| 1970 |
Smits SE, Takemori AE. Quantitative studies on the antagonism by naloxone of some narcotic and narcotic-antagonist analgesics. British Journal of Pharmacology. 39: 627-38. PMID 5472208 |
0.489 |
|
| 1969 |
Takemori AE, Kupferberg HJ, Miller JW. Quantitative studies of the antagonism of morphine by nalorphine and naloxone. The Journal of Pharmacology and Experimental Therapeutics. 169: 39-45. PMID 5804611 |
0.5 |
|
| 1969 |
Dodge PW, Takemori AE. Effect of morphine on cerebral glycolytic intermediates and enzymes of rats in vitro. Biochemical Pharmacology. 18: 1873-82. PMID 4309449 |
0.333 |
|
| 1968 |
Takemori AE. An ultrasensitive method for the determination of morphine and its application in experiments in vitro and in vivo. Biochemical Pharmacology. 17: 1627-35. PMID 5672824 |
0.331 |
|
| 1968 |
Smits SE, Takemori AE. Lack of transfer of morphine tolerance by administration of rat cerebral homogenates. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 127: 1167-71. PMID 5655661 |
0.353 |
|
| 1966 |
Takemori AE, Stenwick MW. Studies on the uptake of morphine by the choroid plexus in vitro. The Journal of Pharmacology and Experimental Therapeutics. 154: 586-94. PMID 5928257 |
0.441 |
|
| 1962 |
TAKEMORI AE. Studies on cellular adaptation to morphine and its reversal by nalorphine in cerebral cortical slices of rats. The Journal of Pharmacology and Experimental Therapeutics. 135: 89-93. PMID 13919215 |
0.305 |
|
| 1962 |
TAKEMORI AE, GLOWACKI GA. Studies on glucuronide synthesis in rats chronically treated with morphine and phenol. Biochemical Pharmacology. 11: 867-70. PMID 13919213 |
0.345 |
|
| 1961 |
TAKEMORI AE. Cellular adaptation to morphine in rats. Science (New York, N.Y.). 133: 1018-9. PMID 13774961 |
0.365 |
|
| 1960 |
LARDY HA, LEE YP, TAKEMORI A. Enzyme responses to thyroid hormones. Annals of the New York Academy of Sciences. 86: 506-11. PMID 14414181 DOI: 10.1111/J.1749-6632.1960.Tb42826.X |
0.471 |
|
| 1960 |
TAKEMORI AE. Enzymic studies on morphine glucronide synthesis in acutely and chronically morphinized rats. The Journal of Pharmacology and Experimental Therapeutics. 130: 370-4. PMID 13774962 |
0.398 |
|
| 1959 |
MANNERING GJ, TAKEMORI AE. The effect of repeated administration of levorphan, dextrophan and morphine on the capacity of rat liver preparations to demethylate morphine- and morphinan-type analgesics. The Journal of Pharmacology and Experimental Therapeutics. 127: 187-90. PMID 14420689 |
0.653 |
|
| 1959 |
LEE YP, TAKEMORI AE, LARDY H. Enhanced oxidation of alpha-glycerophosphate by mitochondria of thyroid-fed rats. The Journal of Biological Chemistry. 234: 3051-4. PMID 14415220 |
0.343 |
|
| 1958 |
TAKEMORI AE, MANNERING GJ. Metabolic N- and O-demethylation of morphine- and morphinan-type analgesics. The Journal of Pharmacology and Experimental Therapeutics. 123: 171-9. PMID 13564392 |
0.593 |
|
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