Jaime Grutzendler - Publications

Affiliations: 
Neurology Yale University, New Haven, CT 
Area:
neuro-glial interactions, optical imaging, neurodegenerative diseases
Website:
http://medicine.yale.edu/neurology/people/jaime_grutzendler.profile

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hill RA, Grutzendler J. Uncovering the biology of myelin with optical imaging of the live brain. Glia. PMID 31033062 DOI: 10.1002/glia.23635  1
2018 Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Publisher Correction: Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Scientific Reports. 8: 17585. PMID 30498261 DOI: 10.1038/s41598-018-36220-7  1
2018 Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Scientific Reports. 8: 14247. PMID 30250218 DOI: 10.1038/s41598-018-32628-3  0.76
2018 Hill RA, Li AM, Grutzendler J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nature Neuroscience. PMID 29556031 DOI: 10.1038/s41593-018-0120-6  1
2018 Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by CSD (67 chrs). Annals of Neurology. PMID 29394508 DOI: 10.1002/ana.25169  0.8
2017 Condello C, Yuan P, Grutzendler J. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging. Biological Psychiatry. PMID 29169609 DOI: 10.1016/j.biopsych.2017.10.007  1
2017 Yang J, Zhang X, Yuan P, Yang J, Xu Y, Grutzendler J, Shao Y, Moore A, Ran C. Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109280 DOI: 10.1073/pnas.1706248114  1
2017 Hill RA, Damisah EC, Chen F, Kwan AC, Grutzendler J. Targeted two-photon chemical apoptotic ablation of defined cell types in vivo. Nature Communications. 8: 15837. PMID 28621306 DOI: 10.1038/ncomms15837  1
2017 Damisah EC, Hill RA, Tong L, Murray KN, Grutzendler J. A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging. Nature Neuroscience. PMID 28504673 DOI: 10.1038/nn.4564  1
2016 Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 92: 252-264. PMID 27710785 DOI: 10.1016/j.neuron.2016.09.016  1
2016 Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 90: 724-739. PMID 27196974 DOI: 10.1016/j.neuron.2016.05.003  1
2016 Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, et al. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of Experimental Medicine. PMID 27091843 DOI: 10.1084/jem.20151948  1
2016 Han L, Kong DK, Zheng M, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, et al. Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. Acs Nano. PMID 26967254 DOI: 10.1021/acsnano.5b07573  1
2016 Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Frontiers in Neuroscience. 10: 46. PMID 26941593 DOI: 10.3389/fnins.2016.00046  1
2016 Yuan P, Grutzendler J. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 632-41. PMID 26758850 DOI: 10.1523/JNEUROSCI.2531-15.2016  1
2015 Velasco MG, Allgeyer ES, Yuan P, Grutzendler J, Bewersdorf J. Absolute two-photon excitation spectra of red and far-red fluorescent probes. Optics Letters. 40: 4915-8. PMID 26512482 DOI: 10.1364/OL.40.004915  1
2015 Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM. Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124111 DOI: 10.1073/pnas.1510329112  1
2015 Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J. Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Neuron. PMID 26119027 DOI: 10.1016/j.neuron.2015.06.001  1
2015 Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nature Communications. 6: 6176. PMID 25630253 DOI: 10.1038/ncomms7176  1
2015 Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aaa9223  1
2014 Hill RA, Grutzendler J. In vivo imaging of oligodendrocytes with sulforhodamine 101. Nature Methods. 11: 1081-2. PMID 25357236 DOI: 10.1038/nmeth.3140  1
2014 Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A. Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division. Nature Neuroscience. 17: 1518-27. PMID 25262495 DOI: 10.1038/nn.3815  1
2014 Zhang X, Tian Y, Yuan P, Li Y, Yaseen MA, Grutzendler J, Moore A, Ran C. A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease. Chemical Communications (Cambridge, England). 50: 11550-3. PMID 25134928 DOI: 10.1039/c4cc03731f  1
2014 Schain AJ, Hill RA, Grutzendler J. Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Nature Medicine. 20: 443-9. PMID 24681598 DOI: 10.1038/nm.3495  1
2014 Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G. Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation. Science Translational Medicine. 6: 226ra31. PMID 24598589 DOI: 10.1126/scitranslmed.3006585  1
2014 Whiteus C, Freitas C, Grutzendler J. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Nature. 505: 407-11. PMID 24305053 DOI: 10.1038/nature12821  1
2013 Grutzendler J. Angiophagy: mechanism of microvascular recanalization independent of the fibrinolytic system. Stroke; a Journal of Cerebral Circulation. 44: S84-6. PMID 23709741 DOI: 10.1161/STROKEAHA.112.678730  1
2013 Harb R, Whiteus C, Freitas C, Grutzendler J. In vivo imaging of cerebral microvascular plasticity from birth to death. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 146-56. PMID 23093067 DOI: 10.1038/jcbfm.2012.152  1
2011 Condello C, Schain A, Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Scientific Reports. 1: 19. PMID 22355538 DOI: 10.1038/srep00019  1
2011 Grutzendler J, Yang G, Pan F, Parkhurst CN, Gan WB. Transcranial two-photon imaging of the living mouse brain. Cold Spring Harbor Protocols. 2011. PMID 21880826 DOI: 10.1101/pdb.prot065474  1
2010 Liu Z, Condello C, Schain A, Harb R, Grutzendler J. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 17091-101. PMID 21159979 DOI: 10.1523/JNEUROSCI.4403-10.2010  1
2010 Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature. 465: 478-82. PMID 20505729 DOI: 10.1038/nature09001  1
2010 Yang G, Pan F, Parkhurst CN, Grutzendler J, Gan WB. Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nature Protocols. 5: 201-8. PMID 20134419 DOI: 10.1038/nprot.2009.222  1
2009 Gan WB, Grutzendler J, Wong RO, Lichtman JW. Ballistic delivery of dyes for structural and functional studies of the nervous system. Cold Spring Harbor Protocols. 2009: pdb.prot5202. PMID 20147144 DOI: 10.1101/pdb.prot5202  1
2007 Grutzendler J, Gan WB. Long-term two-photon transcranial imaging of synaptic structures in the living brain. Csh Protocols. 2007: pdb.prot4766. PMID 21357119  1
2007 Grutzendler J, Helmin K, Tsai J, Gan WB. Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease. Annals of the New York Academy of Sciences. 1097: 30-9. PMID 17413007 DOI: 10.1196/annals.1379.003  1
2006 Grutzendler J, Gan WB. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 489-96. PMID 17012063 DOI: 10.1016/j.nurx.2006.07.005  1
2005 Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neuroscience. 8: 752-8. PMID 15895084 DOI: 10.1038/nn1472  1
2004 Tsai J, Grutzendler J, Duff K, Gan WB. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nature Neuroscience. 7: 1181-3. PMID 15475950 DOI: 10.1038/nn1335  1
2004 Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW. Age-associated synapse elimination in mouse parasympathetic ganglia. Journal of Neurobiology. 60: 214-26. PMID 15266652 DOI: 10.1002/neu.20022  1
2004 Tsai J, Grutzendler J, Gan WB. Optical imaging of synaptic disruption in a mouse model of Alzheimer's disease Microscopy and Microanalysis. 10: 166-167. DOI: 10.1017/S1431927604883740  1
2003 Grutzendler J, Tsai J, Gan WB. Rapid labeling of neuronal populations by ballistic delivery of fluorescent dyes. Methods (San Diego, Calif.). 30: 79-85. PMID 12695105 DOI: 10.1016/S1046-2023(03)00009-4  1
2002 Grutzendler J, Kasthuri N, Gan WB. Long-term dendritic spine stability in the adult cortex. Nature. 420: 812-6. PMID 12490949 DOI: 10.1038/nature01276  1
2001 Grutzendler J, Morris JC. Cholinesterase inhibitors for Alzheimer's disease. Drugs. 61: 41-52. PMID 11217870  1
2001 Nadarajah B, Brunstrom JE, Grutzendler J, Wong RO, Pearlman AL. Two modes of radial migration in early development of the cerebral cortex. Nature Neuroscience. 4: 143-50. PMID 11175874 DOI: 10.1038/83967  1
2000 Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW. Multicolor "DiOlistic" labeling of the nervous system using lipophilic dye combinations. Neuron. 27: 219-25. PMID 10985343  1
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