John R. Cirrito, Ph.D. - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Alzheimer's, amyloid

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Miller RL, Dhavale DD, O'Shea JY, Andruska KM, Liu J, Franklin EE, Buddhala C, Loftin SK, Cirrito JR, Perrin RJ, Cairns NJ, Campbell MC, Perlmutter JS, Kotzbauer PT. Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia. Annals of Clinical and Translational Neurology. PMID 35060360 DOI: 10.1002/acn3.51482  0.619
2021 Rosene MJ, Hsu S, Martinez R, Norton J, Yan P, Cirrito JR, Lee JM, Cuervo AM, Goate AM, Cruchaga C, Karch CM. Defining the role of PLD3 in Alzheimer's disease pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058730. PMID 34971168 DOI: 10.1002/alz.058730  0.45
2021 Izzo NJ, Yuede CM, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Waybright L, Look G, Rishton G, Safferstein H, Hamby ME, Williams C, Sadlek K, Edwards HM, Davis CS, ... ... Cirrito JR, et al. Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33559354 DOI: 10.1002/alz.12302  0.406
2020 Yuede CM, Wallace CE, Davis TA, Gardiner WD, Hettinger JC, Edwards HM, Hendrix RD, Doherty BM, Yuede KM, Burstein ES, Cirrito JR. Pimavanserin, a 5HT receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease. Journal of Neurochemistry. PMID 33278025 DOI: 10.1111/jnc.15260  0.834
2020 George AA, Vieira JM, Xavier-Jackson C, Gee MT, Cirrito JR, Bimonte-Nelson H, Picciotto MR, Lukas RJ, Whiteaker P. Implications of oligomeric amyloid-beta (oAβ42) signaling through α7β2-nicotinic acetylcholine receptors (nAChR) on basal forebrain cholinergic neuronal intrinsic excitability and cognitive decline. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33239400 DOI: 10.1523/JNEUROSCI.0876-20.2020  0.385
2020 Cirrito JR, Wallace CE, Yan P, Davis TA, Gardiner WD, Doherty BM, King D, Yuede CM, Lee JM, Sheline YI. Effect of Escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. PMID 32913022 DOI: 10.1212/Wnl.0000000000010733  0.541
2020 Sheline YI, Snider BJ, Beer JC, Seok D, Fagan AM, Suckow RF, Lee JM, Waligorska T, Korecka M, Aselcioglu I, Morris JC, Shaw LM, Cirrito JR. Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults: A controlled clinical trial. Neurology. PMID 32913021 DOI: 10.1212/Wnl.0000000000010725  0.408
2020 Thomas R, Zimmerman SD, Yuede KM, Cirrito JR, Tai LM, Timson BF, Yuede CM. Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer's Disease. Brain Sciences. 10. PMID 32046299 DOI: 10.3390/Brainsci10020088  0.413
2019 Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, Finn MB, Manis M, Geerling JC, Fuller PM, Lucey BP, Holtzman DM. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science (New York, N.Y.). PMID 30679382 DOI: 10.1126/Science.Aav2546  0.578
2018 Yuede CM, Timson BF, Hettinger JC, Yuede KM, Edwards HM, Lawson JE, Zimmerman SD, Cirrito JR. Interactions between stress and physical activity on Alzheimer's disease pathology. Neurobiology of Stress. 8: 158-171. PMID 29888311 DOI: 10.1016/J.Ynstr.2018.02.004  0.368
2018 Hettinger JC, Lee H, Bu G, Holtzman DM, Cirrito JR. AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model. Molecular Neurodegeneration. 13: 22. PMID 29764453 DOI: 10.1186/S13024-018-0256-6  0.659
2018 Chiang ACA, Fowler SW, Savjani RR, Hilsenbeck SG, Wallace CE, Cirrito JR, Das P, Jankowsky JL. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. The Journal of Experimental Medicine. PMID 29626114 DOI: 10.1084/Jem.20171484  0.476
2017 Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, et al. Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity. The Journal of Experimental Medicine. PMID 28298456 DOI: 10.1084/Jem.20162011  0.737
2017 Liu CC, Hu J, Zhao N, Wang J, Na W, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275161 DOI: 10.1523/Jneurosci.3442-16.2017  0.685
2017 Sheline YI, Snider BJ, Shinohara RT, Fagan AM, Waligorska T, Aselcioglu I, Kristin L, Satchell EK, Cirrito JR, Shaw LM. PROSPECTIVE ESCITALOPRAM DECREASES LONGITUDINAL CSF Aβ CONCENTRATION IN COGNITIVELY NORMAL ELDERLY SUBJECTS: A RANDOMIZED DOSE FINDING STUDY Alzheimer's & Dementia. 13: P1570. DOI: 10.1016/J.Jalz.2017.07.731  0.338
2017 Karch C, Hsu S, Martinez R, Norton J, Cirrito JR, Lee J, Cuervo M, Cruchaga C, Goate A. [O2-18-02]: PHOSPHOLIPASE D3 CONTRIBUTES TO ALZHEIMER's DISEASE RISK VIA DISRUPTION OF Aβ CLEARANCE THROUGH THE LYSOSOME Alzheimer's & Dementia. 13: P602-P603. DOI: 10.1016/J.Jalz.2017.07.248  0.42
2017 Cirrito JR, Wallace CE, Edwards HM. [P1-182]: PHOSPHATASE ACTIVITY DURING SLEEP/WAKE CYCLES REGULATES APP PROCESSING AND BRAIN ISF AMYLOID-β LEVELS Alzheimer's & Dementia. 13: P312-P312. DOI: 10.1016/J.Jalz.2017.06.249  0.398
2017 Yuede CM, Wallace CE, Edwards HM, Yuede KM, Davis TA, Cirrito JR. [P1-170]: INHIBITING GLUCOCORTICOID RECEPTOR DIMERIZATION BLOCKS EFFECTS OF ACUTE STRESS ON Aβ IN FEMALE MICE Alzheimer's & Dementia. 13: P308-P309. DOI: 10.1016/J.Jalz.2017.06.237  0.379
2016 Finan GM, Realubit R, Chung S, Lütjohann D, Wang N, Cirrito JR, Karan C, Kim TW. Bioactive Compound Screen for Pharmacological Enhancers of Apolipoprotein E in Primary Human Astrocytes. Cell Chemical Biology. PMID 27889409 DOI: 10.1016/J.Chembiol.2016.10.015  0.38
2016 Sundaram GS, Dhavale DD, Prior JL, Yan P, Cirrito J, Rath NP, Laforest R, Cairns NJ, Lee JM, Kotzbauer PT, Sharma V. Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease. Scientific Reports. 6: 35636. PMID 27805057 DOI: 10.1038/Srep35636  0.553
2016 Fisher JR, Wallace CE, Tripoli DL, Sheline YI, Cirrito JR. Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo. Molecular Neurodegeneration. 11: 45. PMID 27315796 DOI: 10.1186/S13024-016-0112-5  0.561
2016 Hettinger JC, Cirrito JR. Bad Ac-etylated Tau. Neuron. 90: 205-6. PMID 27100190 DOI: 10.1016/J.Neuron.2016.04.008  0.413
2016 Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, et al. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of Experimental Medicine. PMID 27091843 DOI: 10.1084/Jem.20151948  0.681
2016 Yuede CM, Lee H, Restivo JL, Davis TA, Hettinger JC, Wallace CE, Young KL, Hayne MR, Bu G, Li CZ, Cirrito JR. Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model. The Journal of Experimental Medicine. PMID 27069115 DOI: 10.1084/Jem.20151428  0.614
2016 Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Science Translational Medicine. 8: 332ra44. PMID 27030596 DOI: 10.1126/Scitranslmed.Aad3650  0.7
2016 Wang Y, Ulland T, Ulrich JD, Song W, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, DeMattos RB, Grutzendler J, Cirrito JR, Holtzman DM, Colonna M. O2-07-02: Trem2-Mediated Early Response by Resident Microglia Limits Diffusion and Toxicity of Amyloid Plaques Alzheimer's & Dementia. 12: P241-P242. DOI: 10.1016/J.Jalz.2016.06.431  0.531
2016 Sheline YI, Snider BJ, Korecka M, Shinohara RT, Fagan AM, Mikkelsen EJ, Satchell EK, Cirrito JR, Shaw LM. O1-10-04: Escitalopram Decreases Longitudinal CSF ABETA Concentration in Cognitively Normal Subjects age 60-85 Alzheimer's & Dementia. 12: P199-P199. DOI: 10.1016/J.Jalz.2016.06.349  0.353
2015 Moore KM, Girens RE, Larson SK, Jones MR, Restivo JL, Holtzman DM, Cirrito JR, Yuede CM, Zimmerman SD, Timson BF. A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease. Neurobiology of Disease. PMID 26563933 DOI: 10.1016/J.Nbd.2015.11.004  0.529
2015 Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, et al. microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14717-26. PMID 26538644 DOI: 10.1523/Jneurosci.2053-15.2015  0.822
2015 Bales KR, O'Neill SM, Pozdnyakov N, Pan F, Caouette D, Pi Y, Wood KM, Volfson D, Cirrito JR, Han BH, Johnson AW, Zipfel GJ, Samad TA. Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity. Brain : a Journal of Neurology. PMID 26493635 DOI: 10.1093/Brain/Awv313  0.522
2015 Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12137-51. PMID 26338325 DOI: 10.1523/Jneurosci.0705-15.2015  0.59
2015 Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T. Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease. Cell Reports. 11: 859-65. PMID 25937280 DOI: 10.1016/J.Celrep.2015.04.017  0.61
2015 Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, Robinette ML, Gilfillan S, Krishnan GM, Sudhakar S, Zinselmeyer BH, Holtzman DM, Cirrito JR, Colonna M. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. 160: 1061-71. PMID 25728668 DOI: 10.1016/J.Cell.2015.01.049  0.599
2015 Han BH, Zhou ML, Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proceedings of the National Academy of Sciences of the United States of America. 112: E881-90. PMID 25675483 DOI: 10.1073/Pnas.1414930112  0.808
2015 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Joy Snider B, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Correction to Potential role of orexin and sleep modulation in the pathogenesis of alzheimer's disease [The Journal of Experimental Medicine, 211, 13, (2014), 2487-2496] Journal of Experimental Medicine. 212: 121. DOI: 10.1084/Jem.2014178812122014C  0.475
2014 Sheline YI, West T, Yarasheski K, Jasielec MS, Hettinger JC, Tripoli DL, Xiong C, Frederiksen C, Grzelak MV, Bateman RJ, Morris JC, Lee JM, Cirrito JR. Reply to comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice". Science Translational Medicine. 6: 268lr4. PMID 25540323 DOI: 10.1126/Scitranslmed.3010609  0.739
2014 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. The Journal of Experimental Medicine. 211: 2487-96. PMID 25422493 DOI: 10.1084/Jem.20141788  0.541
2014 Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A, Lee JM. Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9607-20. PMID 25031402 DOI: 10.1523/Jneurosci.3788-13.2014  0.587
2014 Sundaram GS, Garai K, Rath NP, Yan P, Cirrito JR, Cairns NJ, Lee JM, Sharma V. Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice. Organic Letters. 16: 3640-3. PMID 25003699 DOI: 10.1021/Ol501264Q  0.535
2014 Fowler SW, Chiang AC, Savjani RR, Larson ME, Sherman MA, Schuler DR, Cirrito JR, Lesné SE, Jankowsky JL. Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7871-85. PMID 24899710 DOI: 10.1523/Jneurosci.0572-14.2014  0.497
2014 Sheline YI, West T, Yarasheski K, Swarm R, Jasielec MS, Fisher JR, Ficker WD, Yan P, Xiong C, Frederiksen C, Grzelak MV, Chott R, Bateman RJ, Morris JC, Mintun MA, ... ... Cirrito JR, et al. An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice. Science Translational Medicine. 6: 236re4. PMID 24828079 DOI: 10.1126/Scitranslmed.3008169  0.787
2014 Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3826-40. PMID 24623762 DOI: 10.1523/Jneurosci.5171-13.2014  0.55
2014 Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM. Neuronal activity regulates extracellular tau in vivo. The Journal of Experimental Medicine. 211: 387-93. PMID 24534188 DOI: 10.1085/Jgp.1434Oia12  0.526
2014 Paganetti P, Antoniello K, Devraj K, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, et al. Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis. Journal of Alzheimer's Disease : Jad. 38: 767-86. PMID 24072071 DOI: 10.3233/Jad-131091  0.489
2014 Bales K, O'Neill S, Pozdnyakov N, Pan F, Caouette D, Pi Y, Wood KM, Volfson D, Cirrito J, Han BH, Johnson A, Zipfel G, Samad T. Improved Vascular Reactivity And Reduced Cerebral Amyloid Angiopathy Following Passive Immunotherapy In Transgenic Mice Alzheimers & Dementia. 10: 872. DOI: 10.1016/J.Jalz.2014.07.006  0.469
2014 Cirrito J, Sheline Y, Fisher J, Lee J, West T. O2-04-04: SPECIFIC SEROTONIN RECEPTOR SUBTYPES RESPONSIBLE FOR DECREASED CSF AB PRODUCTION Alzheimer's & Dementia. 10: P171-P171. DOI: 10.1016/J.Jalz.2014.04.176  0.532
2013 Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G. Neuronal clearance of amyloid-β by endocytic receptor LRP1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19276-83. PMID 24305823 DOI: 10.1523/Jneurosci.3487-13.2013  0.644
2013 DeVos SL, Goncharoff DK, Chen G, Kebodeaux CS, Yamada K, Stewart FR, Schuler DR, Maloney SE, Wozniak DF, Rigo F, Bennett CF, Cirrito JR, Holtzman DM, Miller TM. Antisense reduction of tau in adult mice protects against seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12887-97. PMID 23904623 DOI: 10.1523/Jneurosci.2107-13.2013  0.554
2013 Landreth GE, Cramer PE, Lakner MM, Cirrito JR, Wesson DW, Brunden KR, Wilson DA. Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-g. PMID 23704556 DOI: 10.1126/Science.1234114  0.396
2013 Ulrich JD, Burchett JM, Restivo JL, Schuler DR, Verghese PB, Mahan TE, Landreth GE, Castellano JM, Jiang H, Cirrito JR, Holtzman DM. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Molecular Neurodegeneration. 8: 13. PMID 23601557 DOI: 10.1186/1750-1326-8-13  0.813
2013 Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls. Annals of Neurology. 73: 104-19. PMID 23225543 DOI: 10.1002/Ana.23748  0.711
2013 Kraft AW, Hu X, Yoon H, Yan P, Xiao Q, Wang Y, Gil SC, Brown J, Wilhelmsson U, Restivo JL, Cirrito JR, Holtzman DM, Kim J, Pekny M, Lee JM. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 187-98. PMID 23038755 DOI: 10.1096/Fj.12-208660  0.77
2013 Fowler S, Chiang A, Savjani R, Larson M, Schuler D, Cirrito J, Lesne S, Jankowsky J. Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD Molecular Neurodegeneration. 8: O30. DOI: 10.1186/1750-1326-8-S1-O30  0.507
2013 Sheline Y, West T, Yarasheski K, Regina K, Swarm R, Kharasch E, Cirrito J, Frederiksen C, Chott R. P4-067: Citalopram decreases acute CSF beta-amyloid concentration in young, healthy study participants Alzheimer's & Dementia. 9: P728-P729. DOI: 10.1016/J.Jalz.2013.05.1456  0.599
2013 Jones M, Zimmerman S, Ehrenstrom R, Cirrito J, Restivo J, Timson B. P4-011: Effect of treadmill running on soluble beta-amyloid concentrations in brains of young Tg2576 mice Alzheimer's & Dementia. 9: P709-P709. DOI: 10.1016/J.Jalz.2013.05.1399  0.591
2012 Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proceedings of the National Academy of Sciences of the United States of America. 109: E2895-903. PMID 22869752 DOI: 10.1073/Pnas.1121081109  0.509
2012 Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Research. 1467: 120-32. PMID 22682924 DOI: 10.1016/J.Brainres.2012.05.048  0.534
2012 Xiao Q, Gil SC, Yan P, Wang Y, Han S, Gonzales E, Perez R, Cirrito JR, Lee JM. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. The Journal of Biological Chemistry. 287: 21279-89. PMID 22539346 DOI: 10.1074/Jbc.M111.338376  0.627
2012 Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM. Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4334-40. PMID 22457485 DOI: 10.1523/Jneurosci.5845-11.2012  0.816
2012 Prabhulkar S, Piatyszek R, Cirrito JR, Wu ZZ, Li CZ. Microbiosensor for Alzheimer's disease diagnostics: detection of amyloid beta biomarkers. Journal of Neurochemistry. 122: 374-81. PMID 22372824 DOI: 10.1111/J.1471-4159.2012.07709.X  0.44
2012 Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science (New York, N.Y.). 335: 1503-6. PMID 22323736 DOI: 10.1126/Science.1217697  0.494
2012 Landreth G, Cramer P, Wesson D, Cirrito J, Brunden K, Wilson D. 44 ApoE-directed therapeutics for the treatment of Alzheimer's disease Neurobiology of Aging. 33: S19. DOI: 10.1016/J.Neurobiolaging.2012.01.062  0.417
2012 Brody D, Esparza T, Zhao H, Cirrito J, Cairns N, Bateman R, Holtzman D. P4-266: BETA-AMYLOID oligomerization in Alzheimer's DISEASE DEMENTIA versus high pathology controls Alzheimer's & Dementia. 8: S752-S752. DOI: 10.1016/J.Jalz.2013.08.047  0.685
2011 Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15861-9. PMID 22049429 DOI: 10.1523/Jneurosci.3272-11.2011  0.698
2011 Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13110-7. PMID 21917794 DOI: 10.1523/Jneurosci.2569-11.2011  0.624
2011 Cirrito JR, Disabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A, Hayreh D, D'Angelo G, Benzinger T, Yoon H, Kim J, Morris JC, Mintun MA, Sheline YI. Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 108: 14968-73. PMID 21873225 DOI: 10.1073/Pnas.1107411108  0.721
2011 Verges DK, Restivo JL, Goebel WD, Holtzman DM, Cirrito JR. Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11328-37. PMID 21813692 DOI: 10.1523/Jneurosci.0607-11.2011  0.552
2011 Kou J, Kim H, Pattanayak A, Song M, Lim JE, Taguchi H, Paul S, Cirrito JR, Ponnazhagan S, Fukuchi K. Anti-Amyloid-β Single-Chain Antibody Brain Delivery Via AAV Reduces Amyloid Load But May Increase Cerebral Hemorrhages in an Alzheimer's Disease Mouse Model. Journal of Alzheimer's Disease : Jad. 27: 23-38. PMID 21709371 DOI: 10.3233/Jad-2011-110230  0.601
2011 Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM. Neuronal activity regulates the regional vulnerability to amyloid-β deposition. Nature Neuroscience. 14: 750-6. PMID 21532579 DOI: 10.1038/Nn.2801  0.822
2011 Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 775-84. PMID 21059748 DOI: 10.1096/Fj.10-167213  0.64
2011 Sheline YI, Cirrito JR. Reply to Pomara and Bruno: Need for prospective, randomized clinical trial Proceedings of the National Academy of Sciences of the United States of America. 108: E1008. DOI: 10.1073/Pnas.1114416108  0.337
2011 Brigham E, Wong A, Rampurna G, Quinn K, Kwong G, Willits C, Wadsworth A, Dofiles L, Pablo FS, Chian D, Santiago P, Hoffman J, Cirrito J, Restivo J, Goldbach E, et al. Variable effects of the gamma-secretase inhibitor ELND006 on Aβ across different compartments (brain, ISF, CSF, and plasma) following sustained exposure via subcutaneous osmotic pumps in wild-type mice Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.911  0.435
2011 Sheline Y, Cirrito J, Morris J, Benzinger T, Mintun M, Disabato B, D'Angelo G. O1-07-03: Antidepressants are associated with lower brain amyloid in cognitively normal humans Alzheimer's & Dementia. 7: S109-S110. DOI: 10.1016/J.Jalz.2011.05.274  0.396
2011 Cirrito J, Xiao Q, Lee J, Wang Y, Gil SC, Yan P, Gonzales E, Perez R. O1-05-02: Role of PICALM in APP internalization, Abeta production and plaque pathogenesis Alzheimer's & Dementia. 7: S104-S104. DOI: 10.1016/J.Jalz.2011.05.257  0.427
2011 Gannon K, Restivo J, Fisher R, Wright J, Cirrito J. P2-458: NPT001 reduces Aβ plaque without altering brain interstitial fluid Aβ levels in aged Tg2576 mice Alzheimer's & Dementia. 7: S459-S460. DOI: 10.1016/J.Jalz.2011.05.1330  0.572
2011 Fisher R, Gannon K, Krishnan R, Tsubery H, Masliah E, Rockenstein E, Kirschner D, Inouye H, Myszka D, Cirrito J, Green K, Wright J, Solomon J, LaFerla F, Solomon B. NPT001: A candidate therapeutic for clearance of beta-amyloid and tau aggregates in Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1328  0.513
2010 Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL. Traumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact study. Neurobiology of Disease. 40: 555-64. PMID 20682338 DOI: 10.1016/J.Nbd.2010.06.018  0.552
2010 Minami SS, Cordova A, Cirrito JR, Tesoriero JA, Babus LW, Davis GC, Dakshanamurthy S, Turner RS, Pak DTs, Rebeck GW, Paige M, Hoe HS. ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Molecular Neurodegeneration. 5: 16. PMID 20406479 DOI: 10.1186/1750-1326-5-16  0.499
2010 Martins RN, Gandy SE, Gupta V, Steele JW, Kim SH, Cirrito J, Lachenmayer L, Ehrlich M, Yue Z, Bharadwaj P, Barr R, Martins I, Morici M, Taddei K, Verdile G. P3-409: Effects of latrepirdine on Aβ clearance, neurotoxicity and aggregation Alzheimer's & Dementia. 6: S572-S573. DOI: 10.1016/J.Jalz.2010.05.1952  0.44
2009 Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration. 4: 51. PMID 20017949 DOI: 10.1186/1750-1326-4-51  0.666
2009 Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science (New York, N.Y.). 326: 1005-7. PMID 19779148 DOI: 10.1126/Science.1180962  0.787
2009 Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee JM. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10706-14. PMID 19710322 DOI: 10.1523/Jneurosci.2637-09.2009  0.826
2009 Cao C, Cirrito JR, Lin X, Wang L, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H. Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice. Journal of Alzheimer's Disease : Jad. 17: 681-97. PMID 19581723 DOI: 10.3233/Jad-2009-1071  0.671
2009 Gandy S, Cirrito J, Steele J, Kim SH, Thinakaran G, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM. S4-04-06: Dimebon®: A Clinically Promising Drug for Alzheimer's Disease, Regulates Amyloid-Beta Metabolism in Cultured Cells, In Isolated Nerve Terminals, and In the Interstitial Fluid of the Living Rodent Brain Alzheimer's & Dementia. 5: e5-e5. DOI: 10.1016/J.Jalz.2009.07.133  0.557
2009 Kraft AW, Hu X, Yan P, Xiao Q, Holmes BB, Wilhelmsson U, Cirrito JR, Holtzman DM, Pekny M, Lee J. Activated astrocytes suppress amyloid plaque pathogenesis in APP/PS1 mice Alzheimers & Dementia. 5: 154. DOI: 10.1016/J.Jalz.2009.05.532  0.661
2009 Cirrito JR. S1-01-06: Synaptic-dependent release of amyloid-beta in vivo Alzheimer's & Dementia. 5: P70-P70. DOI: 10.1016/J.Jalz.2009.05.157  0.364
2008 Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ. Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13542-50. PMID 19074028 DOI: 10.1523/Jneurosci.4686-08.2008  0.67
2008 Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron. 58: 42-51. PMID 18400162 DOI: 10.1016/J.Neuron.2008.02.003  0.643
2008 Cirrito JR, Stewart FR, Mennerick S, Holtzman DM. P4-268: APP endocytosis is required for synaptic-dependent release of amyloid-beta in vivo Alzheimer's & Dementia. 4: T750-T750. DOI: 10.1016/J.Jalz.2008.05.2337  0.535
2008 Lee J, Bero A, Cirrito JR, Hu X, Gonzales E, Perez R, Xiao Q, Holtzman DM, Yan P. O1-03-05: Dynamics of compact plaque growth in APP/PS1 mice Alzheimer's & Dementia. 4: T113-T113. DOI: 10.1016/J.Jalz.2008.05.233  0.776
2008 Kang J, Cirrito J, Lee J, Fujiki N, Nishino S, Holtzman D. P4-081: Diurnal fluctuation of amyloid-β in the brain interstitial fluid of young Tg2576 mice Alzheimer's & Dementia. 4: T692-T692. DOI: 10.1016/J.Jalz.2008.05.2146  0.601
2008 Cirrito JR, Holtzmant DM. Anti-amyloid-Β immunotherapy as a treatment for alzheimer's disease Cns Regeneration. 295-318. DOI: 10.1016/B978-012373994-0.50014-2  0.35
2007 Zeng LH, Ouyang Y, Gazit V, Cirrito JR, Jansen LA, Ess KC, Yamada KA, Wozniak DF, Holtzman DM, Gutmann DH, Wong M. Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiology of Disease. 28: 184-96. PMID 17714952 DOI: 10.1016/J.Nbd.2007.07.015  0.504
2007 Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/Ajpath.2007.070105  0.683
2007 Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM. Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 104: 10673-8. PMID 17551018 DOI: 10.1073/Pnas.0700148104  0.601
2006 Yin KJ, Cirrito JR, Yan P, Hu X, Xiao Q, Pan X, Bateman R, Song H, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, Lee JM. Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10939-48. PMID 17065436 DOI: 10.1523/Jneurosci.2085-06.2006  0.734
2006 Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, Xiao Q, Hsu FF, Turk JW, Xu J, Hsu CY, Holtzman DM, Lee JM. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. The Journal of Biological Chemistry. 281: 24566-74. PMID 16787929 DOI: 10.1074/Jbc.M602440200  0.671
2006 Sheline YI, Snider BJ, Shinohara RT, Fagan AM, Waligorska T, Aselcioglu I, Kristin L, Cirrito JR, Shaw LM. P3-026: DIFFERENTIAL EFFECT OF PROSPECTIVE ESCITALOPRAM DECREASE ON LONGITUDINAL CSF AB CONCENTRATION IN AMYLOID (+) VERSUS AMYLOID (-) COGNITIVELY NORMAL ELDERLY INDIVIDUALS Alzheimer's & Dementia. 14: P1074-P1074. DOI: 10.1016/J.Jalz.2018.06.1381  0.443
2006 Lee J, Hu X, Crick S, Song H, Yin K, Cirrito J, Bateman R, Hsu CY, Xu J, Hsu FF, Turk J, Pappu R, Holtzman DM, Yan P. O4-06-07: MMP-9 degrades fibrilllar abeta in vitro and compact plaques In situ Alzheimer's & Dementia. 2: S89-S89. DOI: 10.1016/J.Jalz.2006.05.342  0.679
2005 Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron. 48: 913-22. PMID 16364896 DOI: 10.1016/J.Neuron.2005.10.028  0.639
2005 Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 115: 3285-90. PMID 16239972 DOI: 10.1172/Jci25247  0.701
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/Jci23269  0.683
2004 DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron. 41: 193-202. PMID 14741101 DOI: 10.1016/S0896-6273(03)00850-X  0.67
2004 Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 1075-80. PMID 14732699 DOI: 10.1073/Pnas.0305803101  0.663
2004 Cirrito JR, O'Dell MA, Bales KR, Paul SM, May PC, DeMattos RB, Holtzman DM. P2-296 Apolipoprotein E delays Aβ elimination in the brain interstitial fluid of young PDAPP mice Neurobiology of Aging. 25: S317. DOI: 10.1016/S0197-4580(04)81041-8  0.586
2003 Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8844-53. PMID 14523085 DOI: 10.1523/Jneurosci.23-26-08844.2003  0.68
2003 Cirrito JR, Holtzman DM. Amyloid beta and Alzheimer disease therapeutics: the devil may be in the details. The Journal of Clinical Investigation. 112: 321-3. PMID 12897198 DOI: 10.1172/Jci19420  0.661
2001 DeMattos RB, Brendza RP, Heuser JE, Kierson M, Cirrito JR, Fryer J, Sullivan PM, Fagan AM, Han X, Holtzman DM. Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice. Neurochemistry International. 39: 415-25. PMID 11578777 DOI: 10.1016/S0197-0186(01)00049-3  0.532
2001 Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony JA, Aronow BJ, Holtzman DM. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nature Medicine. 7: 338-43. PMID 11231633 DOI: 10.1038/85487  0.483
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