Shaun P. Brothers - Publications

Affiliations: 
Neuroscience Scripps Florida, Jupiter, FL, United States 
Area:
GPCRs

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lohse I, Al-Ali H, Volmar CH, D Alvarez Trotta A, Brothers SP, Capobianco AJ, Wahlestedt C. Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma. Plos One. 13: e0203173. PMID 30212533 DOI: 10.1371/journal.pone.0203173  0.92
2018 Johnstone AL, O'Reilly JJ, Patel AJ, Guo Z, Andrade NS, Magistri M, Nathanson L, Esanov R, Miller BH, Turecki G, Brothers SP, Zeier Z, Wahlestedt C. Enhancer of Zeste 1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia. Neurobiology of Disease. PMID 30099093 DOI: 10.1016/j.nbd.2018.08.005  0.92
2017 Mustafi S, Camarena V, Volmar CH, Huff TC, Sant DW, Brothers SP, Liu ZJ, Wahlestedt C, Wang G. Vitamin C sensitizes melanoma to BET inhibitors. Cancer Research. PMID 29180474 DOI: 10.1158/0008-5472.CAN-17-2040  0.92
2017 Swords RT, Azzam D, Al-Ali H, Lohse I, Volmar CH, Watts JM, Perez A, Rodriguez A, Vargas F, Elias R, Vega F, Zelent A, Brothers SP, Abbasi T, Trent J, et al. Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study. Leukemia Research. 64: 34-41. PMID 29175379 DOI: 10.1016/j.leukres.2017.11.008  0.92
2017 Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, et al. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. Proceedings of the National Academy of Sciences of the United States of America. 114: E9135-E9144. PMID 29073110 DOI: 10.1073/pnas.1707544114  0.92
2016 Volmar CH, Wahlestedt C, Brothers SP. Orphan diseases: state of the drug discovery art. Wiener Medizinische Wochenschrift (1946). PMID 26819216 DOI: 10.1007/s10354-015-0423-0  0.6
2015 Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP. "Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice". Brain Research. PMID 26657743 DOI: 10.1016/j.brainres.2015.11.044  0.6
2015 Sartor GC, Powell SK, Brothers SP, Wahlestedt C. Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15062-72. PMID 26558777 DOI: 10.1523/JNEUROSCI.0826-15.2015  1
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS. Experimental Neurology. 271: 241-50. PMID 26099177 DOI: 10.1016/j.expneurol.2015.06.017  0.92
2015 Galoian K, Qureshi A, D'Ippolito G, Schiller PC, Molinari M, Johnstone AL, Brothers SP, Paz AC, Temple HT. Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1. International Journal of Oncology. PMID 26094604 DOI: 10.3892/ijo.2015.3054  1
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS Experimental Neurology. 271: 241-250. DOI: 10.1016/j.expneurol.2015.06.017  1
2014 Carlsson SK, Brothers SP, Wahlestedt C. Emerging treatment strategies for glioblastoma multiforme. Embo Molecular Medicine. 6: 1359-70. PMID 25312641 DOI: 10.15252/emmm.201302627  1
2014 Barrett E, Brothers S, Wahlestedt C, Beurel E. I-BET151 selectively regulates IL-6 production. Biochimica Et Biophysica Acta. 1842: 1549-55. PMID 24859008 DOI: 10.1016/j.bbadis.2014.05.013  1
2014 Karpinsky-Semper D, Volmar CH, Brothers SP, Slepak VZ. Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release. Molecular Pharmacology. 85: 758-68. PMID 24586057 DOI: 10.1124/mol.114.091843  1
2014 Pastori C, Daniel M, Penas C, Volmar CH, Johnstone AL, Brothers SP, Graham RM, Allen B, Sarkaria JN, Komotar RJ, Wahlestedt C, Ayad NG. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics : Official Journal of the Dna Methylation Society. 9: 611-20. PMID 24496381 DOI: 10.4161/epi.27906  1
2013 Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Science Translational Medicine. 5: 188ra73. PMID 23740899 DOI: 10.1126/scitranslmed.3005656  1
2012 Mittapalli GK, Vellucci D, Yang J, Toussaint M, Brothers SP, Wahlestedt C, Roberts E. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 3916-20. PMID 22607676 DOI: 10.1016/j.bmcl.2012.04.107  1
2012 Modarresi F, Faghihi MA, Lopez-Toledano MA, Fatemi RP, Magistri M, Brothers SP, van der Brug MP, Wahlestedt C. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nature Biotechnology. 30: 453-9. PMID 22446693 DOI: 10.1038/nbt.2158  1
2010 Brothers SP, Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands. Embo Molecular Medicine. 2: 429-39. PMID 20972986 DOI: 10.1002/emmm.201000100  1
2010 Faghihi MA, Kocerha J, Modarresi F, Engström PG, Chalk AM, Brothers SP, Koesema E, St Laurent G, Wahlestedt C. RNAi screen indicates widespread biological function for human natural antisense transcripts. Plos One. 5. PMID 20957177 DOI: 10.1371/journal.pone.0013177  1
2010 Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Molecular Pharmacology. 77: 46-57. PMID 19837904 DOI: 10.1124/mol.109.058677  1
2008 Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C. A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. Plos One. 3: e1486. PMID 18213394 DOI: 10.1371/journal.pone.0001486  1
2007 Janovick JA, Brothers SP, Cornea A, Bush E, Goulet MT, Ashton WT, Sauer DR, Haviv F, Greer J, Conn PM. Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro. Molecular and Cellular Endocrinology. 272: 77-85. PMID 17555869 DOI: 10.1016/j.mce.2007.04.012  1
2007 Janovick JA, Brothers SP, Knollman PE, Conn PM. Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 384-92. PMID 17172315 DOI: 10.1096/fj.06-6901com  1
2006 Brothers SP, Janovick JA, Conn PM. Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression. Journal of Molecular Endocrinology. 37: 479-88. PMID 17170088 DOI: 10.1677/jme.1.02142  1
2006 Conn PM, Janovick JA, Brothers SP, Knollman PE. 'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation. The Journal of Endocrinology. 190: 13-6. PMID 16837606 DOI: 10.1677/joe.1.06771  1
2006 Conn PM, Knollman PE, Brothers SP, Janovick JA. Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor. Molecular Endocrinology (Baltimore, Md.). 20: 3035-41. PMID 16556733 DOI: 10.1210/me.2006-0066  1
2006 Janovick JA, Knollman PE, Brothers SP, Ayala-Yáñez R, Aziz AS, Conn PM. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. The Journal of Biological Chemistry. 281: 8417-25. PMID 16446355 DOI: 10.1074/jbc.M510601200  1
2005 Knollman PE, Janovick JA, Brothers SP, Conn PM. Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants. The Journal of Biological Chemistry. 280: 24506-14. PMID 15886197 DOI: 10.1074/jbc.M501978200  1
2004 Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM. Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic (Copenhagen, Denmark). 5: 821-37. PMID 15479448 DOI: 10.1111/j.1600-0854.2004.00232.x  1
2004 Brothers SP, Cornea A, Janovick JA, Conn PM. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Molecular Endocrinology (Baltimore, Md.). 18: 1787-97. PMID 15105440 DOI: 10.1210/me.2004-0091  1
2003 Brothers SP, Janovick JA, Conn PM. Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 88: 6107-12. PMID 14671217 DOI: 10.1210/jc.2003-031047  1
2003 Castro-Fernández C, Brothers SP, Michael Conn P. A Galphas mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T. Molecular and Cellular Endocrinology. 200: 119-26. PMID 12644305  0.48
2003 Castro-Fernández C, Brothers SP, Conn PM. A Gαs mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T Molecular and Cellular Endocrinology. 200: 119-126. DOI: 10.1016/S0303-7207(02)00378-7  1
2002 Castro-Ferna Ndez C, Janovick JA, Brothers SP, Fisher RA, Ji TH, Conn PM. Regulation of RGS3 and RGS10 Palmitoylation by GnRH. Endocrinology. 143: 1310-1317. PMID 28201603 DOI: 10.1210/endo.143.4.8713  1
2002 Brothers SP, Janovick JA, Maya-Nunez G, Cornea A, Han XB, Conn PM. Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization. Molecular and Cellular Endocrinology. 190: 19-27. PMID 11997175 DOI: 10.1016/S0303-7207(02)00040-0  1
2002 Castro-Fernández C, Janovick JA, Brothers SP, Fisher RA, Ji TH, Conn PM. Regulation of RGS3 and RGS10 palmitoylation by GnRH. Endocrinology. 143: 1310-7. PMID 11897687 DOI: 10.1210/endo.143.4.8713  1
1999 Lin X, Janovick JA, Brothers S, Conn PM, Peter RE. Molecular cloning and expression of two type one somatostatin receptors in goldfish brain. Endocrinology. 140: 5211-9. PMID 10537151 DOI: 10.1210/endo.140.11.7094  1
1998 Ulloa-Aguirre A, Stanislaus D, Arora V, Väänänen J, Brothers S, Janovick JA, Conn PM. The third intracellular loop of the rat gonadotropin-releasing hormone receptor couples the receptor to Gs- and G(q/11)-mediated signal transduction pathways: evidence from loop fragment transfection in GGH3 cells. Endocrinology. 139: 2472-8. PMID 9564860 DOI: 10.1210/endo.139.5.6022  1
1998 Lin X, Janovick JA, Brothers S, Blömenrohr M, Bogerd J, Conn PM. Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation. Molecular Endocrinology (Baltimore, Md.). 12: 161-71. PMID 9482659 DOI: 10.1210/mend.12.2.0056  1
1997 Stanislaus D, Janovick JA, Brothers S, Conn PM. Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. Molecular Endocrinology (Baltimore, Md.). 11: 738-46. PMID 9171237 DOI: 10.1210/mend.11.6.0005  1
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