| Year |
Citation |
Score |
| 2022 |
Ding Q, Chorazyczewski J, Gros R, Motulsky HJ, Limbird LE, Feldman RD. Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist. Pharmacology Research & Perspectives. 10: e00995. PMID 36065843 DOI: 10.1002/prp2.995 |
0.399 |
|
| 2015 |
Feldman RD, Limbird LE. Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe. Trends in Endocrinology and Metabolism: Tem. 26: 592-4. PMID 26482875 DOI: 10.1016/j.tem.2015.09.002 |
0.46 |
|
| 2011 |
Limbird LE. Historical perspective for understanding of adrenergic receptors. Current Topics in Membranes. 67: 1-17. PMID 21771483 DOI: 10.1016/B978-0-12-384921-2.00001-X |
0.426 |
|
| 2011 |
Brady AE, Chen Y, Limbird LE, Wang Q. Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 746: 347-55. PMID 21607867 DOI: 10.1007/978-1-61779-126-0_19 |
0.764 |
|
| 2010 |
Lu R, Chen Y, Cottingham C, Peng N, Jiao K, Limbird LE, Wyss JM, Wang Q. Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor. Molecular Pharmacology. 78: 279-86. PMID 20430865 DOI: 10.1124/mol.110.065300 |
0.437 |
|
| 2009 |
Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. The Journal of Biological Chemistry. 284: 13233-43. PMID 19276088 DOI: 10.1074/Jbc.M807535200 |
0.475 |
|
| 2009 |
Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. The Journal of Biological Chemistry. 284: 5742-52. PMID 19106094 DOI: 10.1074/jbc.M808507200 |
0.374 |
|
| 2009 |
Nag S, Wang Q, Limbird LE, Mokha SS. Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behavioural Brain Research. 197: 457-61. PMID 18957308 DOI: 10.1016/j.bbr.2008.09.036 |
0.406 |
|
| 2007 |
Wang Q, Limbird LE. Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochemical Pharmacology. 73: 1135-45. PMID 17229402 DOI: 10.1016/j.bcp.2006.12.024 |
0.336 |
|
| 2006 |
Wang Q, Lu R, Zhao J, Limbird LE. Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation. The Journal of Biological Chemistry. 281: 25948-55. PMID 16809338 DOI: 10.1074/jbc.M605415200 |
0.402 |
|
| 2005 |
Hu X, Friedman D, Hill S, Caprioli R, Nicholson W, Powers AC, Hunter L, Limbird LE. Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of Molecular Endocrinology. 35: 73-88. PMID 16087723 DOI: 10.1677/Jme.1.01764 |
0.312 |
|
| 2005 |
Brady AE, Wang Q, Allen PB, Rizzo M, Greengard P, Limbird LE. Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype. Molecular Pharmacology. 67: 1690-6. PMID 15705742 DOI: 10.1124/Mol.104.005215 |
0.8 |
|
| 2004 |
Limbird LE. The receptor concept: a continuing evolution. Molecular Interventions. 4: 326-36. PMID 15616162 DOI: 10.1124/mi.4.6.6 |
0.465 |
|
| 2004 |
Zhang YQ, Limbird LE. Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles. Biochemical Society Transactions. 32: 856-60. PMID 15494033 DOI: 10.1042/BST0320856 |
0.412 |
|
| 2004 |
Brady AE, Wang Q, Limbird LE. Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 259: 371-8. PMID 15250505 DOI: 10.1385/1-59259-754-8:371 |
0.765 |
|
| 2004 |
Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (New York, N.Y.). 304: 1940-4. PMID 15218143 DOI: 10.1126/Science.1098274 |
0.801 |
|
| 2004 |
Tan CM, Brady AE, Nickols HH, Wang Q, Limbird LE. Membrane trafficking of G protein-coupled receptors. Annual Review of Pharmacology and Toxicology. 44: 559-609. PMID 14744258 DOI: 10.1146/Annurev.Pharmtox.44.101802.121558 |
0.771 |
|
| 2004 |
Limbird LE. α2-Adrenergic Receptors Primer On the Autonomic Nervous System: Second Edition. 54-56. DOI: 10.1016/B978-012589762-4/50013-X |
0.328 |
|
| 2003 |
Tan CM, Nickols HH, Limbird LE. Appropriate polarization following pharmacological rescue of V2 vasopressin receptors encoded by X-linked nephrogenic diabetes insipidus alleles involves a conformation of the receptor that also attains mature glycosylation. The Journal of Biological Chemistry. 278: 35678-86. PMID 12824183 DOI: 10.1074/Jbc.M301888200 |
0.309 |
|
| 2003 |
Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. The Journal of Biological Chemistry. 278: 32405-12. PMID 12738775 DOI: 10.1074/Jbc.M304195200 |
0.755 |
|
| 2002 |
Wang Q, Limbird LE. Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3. The Journal of Biological Chemistry. 277: 50589-96. PMID 12376539 DOI: 10.1074/jbc.M208503200 |
0.399 |
|
| 2002 |
Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8771-7. PMID 12351753 |
0.473 |
|
| 2002 |
Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proceedings of the National Academy of Sciences of the United States of America. 99: 12471-6. PMID 12205290 DOI: 10.1073/Pnas.122368499 |
0.571 |
|
| 2002 |
Brady AE, Limbird LE. G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cellular Signalling. 14: 297-309. PMID 11858937 DOI: 10.1016/S0898-6568(01)00239-X |
0.78 |
|
| 2002 |
Wozniak M, Saunders C, Schramm N, Keefer JR, Limbird LE. Morphological and biochemical strategies for monitoring trafficking of epitope-tagged G protein-coupled receptors in agonist-naive and agonist-occupied states. Methods in Enzymology. 343: 530-44. PMID 11665590 DOI: 10.1016/S0076-6879(02)43156-4 |
0.802 |
|
| 2002 |
Tan CM, Limbird LE. Receptors in disease: A focus on G protein-coupled receptors Pharmaceutical News. 9: 327-336. DOI: 10.1080/10718940216620 |
0.535 |
|
| 2001 |
Schramm NL, McDonald MP, Limbird LE. The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4875-82. PMID 11425914 |
0.763 |
|
| 2001 |
Wilson MH, Highfield HA, Limbird LE. The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnover. Molecular Pharmacology. 59: 929-38. PMID 11259639 |
0.462 |
|
| 2001 |
Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. The Journal of Biological Chemistry. 276: 15003-8. PMID 11154706 DOI: 10.1074/Jbc.M011679200 |
0.774 |
|
| 2000 |
Edwards SW, Tan CM, Limbird LE. Localization of G-protein-coupled receptors in health and disease. Trends in Pharmacological Sciences. 21: 304-8. PMID 10918636 DOI: 10.1016/S0165-6147(00)01513-3 |
0.446 |
|
| 2000 |
Kingery WS, Guo TZ, Davies MF, Limbird L, Maze M. The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain. 85: 345-58. PMID 10781908 DOI: 10.1016/S0304-3959(99)00286-9 |
0.424 |
|
| 2000 |
Wilson MH, Limbird LE. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Biochemistry. 39: 693-700. PMID 10651634 DOI: 10.1021/bi9920275 |
0.454 |
|
| 2000 |
Saunders C, Limbird LE. Microtubule-dependent regulation of alpha(2B) adrenergic receptors in polarized MDCKII cells requires the third intracellular loop but not G protein coupling. Molecular Pharmacology. 57: 44-52. PMID 10617677 |
0.397 |
|
| 1999 |
Saunders C, Limbird LE. Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues. Pharmacology & Therapeutics. 84: 193-205. PMID 10596906 DOI: 10.1016/S0163-7258(99)00032-7 |
0.477 |
|
| 1999 |
Schramm NL, Limbird LE. Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. The Journal of Biological Chemistry. 274: 24935-40. PMID 10455169 DOI: 10.1074/jbc.274.35.24935 |
0.795 |
|
| 1999 |
Hein L, Limbird LE, Eglen RM, Kobilka BK. Gene substitution/knockout to delineate the role of alpha 2-adrenoceptor subtypes in mediating central effects of catecholamines and imidazolines. Annals of the New York Academy of Sciences. 881: 265-71. PMID 10415924 DOI: 10.1111/J.1749-6632.1999.Tb09368.X |
0.612 |
|
| 1999 |
Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Molecular Pharmacology. 56: 154-61. PMID 10385696 DOI: 10.1124/Mol.56.1.154 |
0.627 |
|
| 1999 |
Limbird LE, Vaughan DE. Augmenting beta receptors in the heart: short-term gains offset by long-term pains? Proceedings of the National Academy of Sciences of the United States of America. 96: 7125-7. PMID 10377378 DOI: 10.1073/Pnas.96.13.7125 |
0.396 |
|
| 1999 |
Edwards SW, Limbird LE. Role for the third intracellular loop in cell surface stabilization of the alpha2A-adrenergic receptor. The Journal of Biological Chemistry. 274: 16331-6. PMID 10347190 DOI: 10.1074/jbc.274.23.16331 |
0.352 |
|
| 1999 |
Prezeau L, Richman JG, Edwards SW, Limbird LE. The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. The Journal of Biological Chemistry. 274: 13462-9. PMID 10224112 DOI: 10.1074/jbc.274.19.13462 |
0.443 |
|
| 1998 |
MacMillan LB, Lakhlani P, Lovinger D, Limbird LE. Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings. Recent Progress in Hormone Research. 53: 25-42. PMID 9769701 |
0.384 |
|
| 1998 |
Saunders C, Keefer JR, Bonner CA, Limbird LE. Targeting of G protein-coupled receptors to the basolateral surface of polarized renal epithelial cells involves multiple, non-contiguous structural signals. The Journal of Biological Chemistry. 273: 24196-206. PMID 9727043 DOI: 10.1074/jbc.273.37.24196 |
0.304 |
|
| 1998 |
Wozniak M, Limbird LE. Trafficking itineraries of G protein-coupled receptors in epithelial cells do not predict receptor localization in neurons. Brain Research. 780: 311-22. PMID 9507174 DOI: 10.1016/S0006-8993(97)01216-X |
0.412 |
|
| 1998 |
Janumpalli S, Butler LS, MacMillan LB, Limbird LE, McNamara JO. A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2004-8. PMID 9482787 DOI: 10.1523/Jneurosci.18-06-02004.1998 |
0.444 |
|
| 1998 |
MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. Advances in Pharmacology (San Diego, Calif.). 42: 493-6. PMID 9327947 DOI: 10.1016/S1054-3589(08)60796-6 |
0.306 |
|
| 1997 |
Wang RX, Limbird LE. Distribution of mRNA encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2A subtype in apoptosis. Molecular Pharmacology. 52: 1071-80. PMID 9415717 DOI: 10.1124/MOL.52.6.1071 |
0.313 |
|
| 1997 |
Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 9950-5. PMID 9275232 DOI: 10.1073/pnas.94.18.9950 |
0.36 |
|
| 1997 |
Saunders C, Limbird LE. Disruption of microtubules reveals two independent apical targeting mechanisms for G-protein-coupled receptors in polarized renal epithelial cells. The Journal of Biological Chemistry. 272: 19035-45. PMID 9228087 DOI: 10.1074/jbc.272.30.19035 |
0.378 |
|
| 1997 |
Wozniak M, Keefer JR, Saunders C, Limbird LE. Differential targeting and retention of G protein-coupled receptors in polarized epithelial cells. Journal of Receptor and Signal Transduction Research. 17: 373-83. PMID 9029502 DOI: 10.3109/10799899709036615 |
0.495 |
|
| 1997 |
MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In Vivo Mutation of the α2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes Advances in Pharmacology. 42: 493-496. DOI: 10.1016/S1054-3589(08)60796-6 |
0.385 |
|
| 1996 |
Wang R, Macmillan LB, Fremeau RT, Magnuson MA, Lindner J, Limbird LE. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience. 74: 199-218. PMID 8843087 DOI: 10.1016/0306-4522(96)00116-9 |
0.436 |
|
| 1996 |
Lakhlani PP, Lovinger DM, Limbird LE. Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling. Molecular Pharmacology. 50: 96-103. PMID 8700125 |
0.434 |
|
| 1996 |
MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE. Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science (New York, N.Y.). 273: 801-3. PMID 8670421 DOI: 10.1126/Science.273.5276.801 |
0.397 |
|
| 1996 |
Lanier SM, Lafontan M, Limbird LE, Paris H. Summary of the ASPET-sponsored Colloquium: Alpha-2 adrenergic receptors: structure, function, and therapeutic implications, October 25-27, 1995. The Journal of Pharmacology and Experimental Therapeutics. 277: 10-6. PMID 8613905 |
0.43 |
|
| 1996 |
Saunders C, Keefer JR, Kennedy AP, Wells JN, Limbird LE. Receptors coupled to pertussis toxin-sensitive G-proteins traffic to opposite surfaces in Madin-Darby canine kidney cells. A1 adenosine receptors achieve apical and alpha 2A adrenergic receptors achieve basolateral localization. The Journal of Biological Chemistry. 271: 995-1002. PMID 8557716 DOI: 10.1074/jbc.271.2.995 |
0.453 |
|
| 1996 |
Saunders C, Keefer JR, Limbird LE. Receptor chimeras and truncations reveal α2a adrenergic receptor (a2aar) domains involved in its basolateral localization in mdckii cells Faseb Journal. 10: A419. |
0.4 |
|
| 1994 |
Keefer JR, Kennedy ME, Limbird LE. Unique structural features important for stabilization versus polarization of the alpha 2A-adrenergic receptor on the basolateral membrane of Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 269: 16425-32. PMID 8206950 |
0.39 |
|
| 1994 |
Kennedy ME, Limbird LE. Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation. The Journal of Biological Chemistry. 269: 31915-22. PMID 7989367 |
0.439 |
|
| 1994 |
Ceresa BP, Limbird LE. Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling. The Journal of Biological Chemistry. 269: 29557-64. PMID 7961941 |
0.51 |
|
| 1994 |
Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. The Journal of Biological Chemistry. 269: 5730-4. PMID 7907086 |
0.502 |
|
| 1994 |
Keefer JR, Nunnari J, Pang IH, Limbird LE. Introduction of purified alpha 2A-adrenergic receptors into uniformly oriented, unilamellar, phospholipid vesicles: productive coupling to G proteins but lack of receptor-dependent ion transport. Molecular Pharmacology. 45: 1071-81. PMID 7517495 |
0.718 |
|
| 1993 |
Keefer JR, Limbird LE. The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins. The Journal of Biological Chemistry. 268: 11340-7. PMID 8388390 |
0.435 |
|
| 1993 |
Kennedy ME, Limbird LE. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. The Journal of Biological Chemistry. 268: 8003-11. PMID 8385131 |
0.516 |
|
| 1992 |
Domino SE, Repaske MG, Bonner CA, Kennedy ME, Wilson AL, Brandon S, Limbird LE. Synthesis of a yohimbine-agarose matrix useful for large-scale and micropurification of multiple alpha 2-receptor subtypes. Methods in Enzymology. 215: 181-200. PMID 1359387 DOI: 10.1016/0076-6879(92)15063-I |
0.451 |
|
| 1992 |
Surprenant A, Horstman DA, Akbarali H, Limbird LE. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science (New York, N.Y.). 257: 977-80. PMID 1354394 |
0.404 |
|
| 1992 |
Wilson AL, Womble SW, Prakash C, Cragoe EJ, Blair IA, Limbird LE. Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange. Molecular Pharmacology. 42: 175-9. PMID 1325028 |
0.416 |
|
| 1991 |
Wilson AL, Seibert K, Brandon S, Cragoe EJ, Limbird LE. Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype. Molecular Pharmacology. 39: 481-6. PMID 1850091 |
0.428 |
|
| 1990 |
Clarke JD, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors regulate Na(+)-H+ exchange via a cAMP-dependent mechanism. The American Journal of Physiology. 259: F977-85. PMID 2175564 |
0.438 |
|
| 1990 |
Horstman DA, Brandon S, Wilson AL, Guyer CA, Cragoe EJ, Limbird LE. An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. The Journal of Biological Chemistry. 265: 21590-5. PMID 2174879 |
0.498 |
|
| 1990 |
Wilson AL, Guyer CA, Cragoe EJ, Limbird LE. The hydrophobic tryptic core of the porcine alpha 2-adrenergic receptor retains allosteric modulation of binding by Na+, H+, and 5-amino-substituted amiloride analogs. The Journal of Biological Chemistry. 265: 17318-22. PMID 2170372 |
0.406 |
|
| 1990 |
Guyer CA, Horstman DA, Wilson AL, Clark JD, Cragoe EJ, Limbird LE. Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. The Journal of Biological Chemistry. 265: 17307-17. PMID 2170371 |
0.497 |
|
| 1988 |
Sweatt JD, Connolly TM, Baron BM, Limbird LE. Involvement of Na+/H+ exchange in human platelet activation. Progress in Clinical and Biological Research. 283: 523-57. PMID 2850577 |
0.453 |
|
| 1988 |
Limbird LE. Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2686-95. PMID 2840317 |
0.422 |
|
| 1987 |
Nunnari JM, Repaske MG, Brandon S, Cragoe EJ, Limbird LE. Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange. The Journal of Biological Chemistry. 262: 12387-92. PMID 3040742 |
0.711 |
|
| 1987 |
Repaske MG, Nunnari JM, Limbird LE. Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix. The Journal of Biological Chemistry. 262: 12381-6. PMID 3040741 |
0.728 |
|
| 1987 |
Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Synthesis and characterization of arylamine derivatives of rauwolscine as molecular probes for alpha 2-adrenergic receptors. Hypertension. 9: III120-4. PMID 2885270 DOI: 10.1161/01.HYP.9.6_Pt_2.III120 |
0.702 |
|
| 1987 |
Isom LL, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. The Journal of Biological Chemistry. 262: 6750-7. PMID 2883187 |
0.463 |
|
| 1987 |
Isom LL, Cragoe EJ, Limbird LE. Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation. The Journal of Biological Chemistry. 262: 17504-9. PMID 2826423 |
0.444 |
|
| 1987 |
Sweatt JD, Schwartzberg MS, Frazer M, Cragoe EJ, Blair IA, Reed PW, Limbird LE. Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. Circulation Research. 61: II6-11. PMID 2822286 |
0.462 |
|
| 1987 |
Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Synthesis and characterization of arylamine derivatives of rauwolscine as molecular probes for α2-adrenergic receptors Hypertension. 9: III-120-III-124. |
0.305 |
|
| 1986 |
Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Photoaffinity labeling of the porcine brain alpha 2-adrenergic receptor using a radioiodinated arylazide derivative of rauwolscine: identification of the hormone-binding subunit. Proceedings of the National Academy of Sciences of the United States of America. 83: 9358-62. PMID 3025837 DOI: 10.1073/pnas.83.24.9358 |
0.714 |
|
| 1986 |
Sweatt JD, Connolly TM, Cragoe EJ, Limbird LE. Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. The Journal of Biological Chemistry. 261: 8667-73. PMID 3013859 |
0.512 |
|
| 1986 |
Sweatt JD, Blair IA, Cragoe EJ, Limbird LE. Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step. The Journal of Biological Chemistry. 261: 8660-6. PMID 3013858 |
0.471 |
|
| 1985 |
Sweatt JD, Johnson SL, Cragoe EJ, Limbird LE. Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin. The Journal of Biological Chemistry. 260: 12910-9. PMID 2997148 |
0.493 |
|
| 1985 |
Limbird LE, Connolly TM, Sweatt JD, Uderman HD. Human platelet alpha 2-adrenergic receptors: effect of Na+ on interaction with the adenylate cyclase system and on epinephrine-stimulated platelet secretion. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 19: 235-42. PMID 2988299 |
0.607 |
|
| 1985 |
Limbird LE, MacMillan ST, Kalinoski DL. The resolution of agonist alpha 2-adrenergic receptor complexes from unoccupied receptors or antagonist-alpha 2 receptor complexes using DEAE chromatography. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 10: 75-82. PMID 2858502 |
0.505 |
|
| 1985 |
Sweatt JD, Limbird LE. Na+ and fibrinogen are required for release of arachidonic acid (AA) from human platelets in response to epinephrine, ADP and 0.004 U/ml thrombin Federation Proceedings. 44: No. 7341. |
0.442 |
|
| 1984 |
Segaloff DL, May J, Schomberg DW, Limbird LE. A model system for the biochemical study of luteinizing hormone/chorionic gonadotropin receptor synthesis. Biochimica Et Biophysica Acta. 804: 31-6. PMID 6326843 DOI: 10.1016/0167-4889(84)90095-8 |
0.368 |
|
| 1984 |
Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Leukocyte beta-receptor alterations in hypertensive subjects. The Journal of Clinical Investigation. 73: 648-53. PMID 6323524 DOI: 10.1172/JCI111255 |
0.334 |
|
| 1984 |
Limbird LE. GTP and Na+ modulate receptor-adenyl cyclase coupling and receptor-mediated function. The American Journal of Physiology. 247: E59-68. PMID 6146263 |
0.469 |
|
| 1984 |
Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly. The New England Journal of Medicine. 310: 815-9. PMID 6142419 DOI: 10.1056/NEJM198403293101303 |
0.371 |
|
| 1983 |
Connolly TM, Limbird LE. Removal of extraplatelet Na+ eliminates indomethacin-sensitive secretion from human platelets stimulated by epinephrine, ADP, and thrombin. Proceedings of the National Academy of Sciences of the United States of America. 80: 5320-4. PMID 6577431 DOI: 10.1073/Pnas.80.17.5320 |
0.583 |
|
| 1983 |
Segaloff DL, Limbird LE. Luteinizing hormone receptor appearance in cultured porcine granulosa cells requires continual presence of follicle-stimulating hormone. Proceedings of the National Academy of Sciences of the United States of America. 80: 5631-5. PMID 6310585 |
0.363 |
|
| 1983 |
Limbird LE, Buhrow SA, Speck JL, Staros JV. 5'-p-Fluorosulfonylbenzoyl guanosine as a probe for the GTP-binding protein in alpha 2-adrenergic receptor-adenylate cyclase systems. The Journal of Biological Chemistry. 258: 10289-93. PMID 6309799 |
0.44 |
|
| 1983 |
Feldman RD, Limbird LE, Nadeau J, FitzGerald GA, Robertson D, Wood AJ. Dynamic regulation of leukocyte beta adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines. The Journal of Clinical Investigation. 72: 164-70. PMID 6308044 DOI: 10.1172/Jci110954 |
0.401 |
|
| 1983 |
Segaloff DL, Limbird LE. The cAMP-Dependent induction of LH receptors in primary cultures of porcine granulosa cells is not due to the expression of an intracellular pool of LH receptors. Endocrinology. 113: 825-7. PMID 6307657 DOI: 10.1210/Endo-113-2-825 |
0.451 |
|
| 1983 |
Connolly TM, Limbird LE. The influence of Na+ on the alpha 2-adrenergic receptor system of human platelets. A method for removal of extraplatelet Na+. Effect of Na+ removal on aggregation, secretion, and cAMP accumulation. The Journal of Biological Chemistry. 258: 3907-12. PMID 6300061 |
0.331 |
|
| 1983 |
Limbird LE, Speck JL. N-ethylmaleimide, elevated temperature, and digitonin solubilization eliminate guanine nucleotide but not sodium effects on human platelet alpha 2-adrenergic receptor-agonist interactions. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 9: 191-201. PMID 6142062 |
0.514 |
|
| 1983 |
Limbird LE. Beta-adrenergic stimulation of adenylate cyclase and alpha-adrenergic inhibition of adenylate cyclase: GTP-binding proteins as macromolecular messengers. Advances in Experimental Medicine and Biology. 161: 91-111. PMID 6135310 |
0.357 |
|
| 1982 |
Smith SK, Limbird LE. Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin. The Journal of Biological Chemistry. 257: 10471-8. PMID 6286654 |
0.547 |
|
| 1982 |
Limbird LE, Speck JL, Smith SK. Sodium ion modulates agonist and antagonist interactions with the human platelet alpha 2-adrenergic receptor in membrane and solubilized preparations. Molecular Pharmacology. 21: 609-17. PMID 6125876 |
0.415 |
|
| 1982 |
Smith SK, Limbird LE. Apparent independence of the alpha-adrenergic receptor (α-AR) of the human platelet from the ADP-ribosylated 42,000 Mr subunit of the adenylate cyclase system Federation Proceedings. 41: No. 3682. |
0.413 |
|
| 1981 |
Limbird LE. Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor--cyclase coupling. The Biochemical Journal. 195: 1-13. PMID 6272740 |
0.427 |
|
| 1981 |
Smith SK, Limbird LE. Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions. Proceedings of the National Academy of Sciences of the United States of America. 78: 4026-30. PMID 6270654 |
0.501 |
|
| 1981 |
Lefkowitz RJ, De Lean A, Hoffman BB, Stadel JM, Kent R, Michel T, Limbird L. Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. Advances in Cyclic Nucleotide Research. 14: 145-61. PMID 6269377 |
0.589 |
|
| 1981 |
Stadel JM, Shorr RG, Limbird LE, Lefkowitz RJ. Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. The Journal of Biological Chemistry. 256: 8718-23. PMID 6267049 |
0.547 |
|
| 1981 |
Limbird LE, MacMillan ST, Smith SK. Solubilization of human platelet alpha-adrenergic receptors: evidence for agonist-promoted receptor-effector association. Advances in Cyclic Nucleotide Research. 14: 189-98. PMID 6116384 |
0.483 |
|
| 1980 |
Limbird LE, Gill DM, Lefkowitz RJ. Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proceedings of the National Academy of Sciences of the United States of America. 77: 775-9. PMID 6244585 DOI: 10.1073/Pnas.77.2.775 |
0.611 |
|
| 1980 |
Limbird LE, Gill DM, Stadel JM, Hickey AR, Lefkowitz RJ. Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. The Journal of Biological Chemistry. 255: 1854-61. PMID 6243651 |
0.529 |
|
| 1979 |
Limbird LE, Hickey AR, Lefkowitz RJ. The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. Journal of Cyclic Nucleotide Research. 5: 251-9. PMID 573291 |
0.493 |
|
| 1979 |
Limbird LE, Hickey AR, Lefkowitz RJ. Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. The Journal of Biological Chemistry. 254: 2677-83. PMID 429310 |
0.397 |
|
| 1979 |
Caron MG, Limbird LE, Lefkowitz RJ. Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. Molecular and Cellular Biochemistry. 28: 45-66. PMID 231201 DOI: 10.1007/BF00223359 |
0.678 |
|
| 1979 |
Limbird LE, DeLean A, Hickey AR, Pike LJ, Lefkowitz RJ. Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. Biochimica Et Biophysica Acta. 586: 298-314. PMID 224939 DOI: 10.1016/0304-4165(79)90101-6 |
0.75 |
|
| 1979 |
Pike LJ, Limbird LE, Lefkowitz RJ. Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. Nature. 280: 502-4. PMID 37448 DOI: 10.1038/280502A0 |
0.676 |
|
| 1978 |
Lefkowitz RJ, Limbird LE, Williams LT, Wessels M. Beta-adrenergic receptors: regulatory role of agonists. Journal of Supramolecular Structure. 8: 501-10. PMID 31515 DOI: 10.1002/Jss.400080412 |
0.79 |
|
| 1978 |
Limbird LE, Lefkowitz RJ. Agonist-induced increase in apparent beta-adrenergic receptor size. Proceedings of the National Academy of Sciences of the United States of America. 75: 228-32. PMID 24213 DOI: 10.1073/Pnas.75.1.228 |
0.578 |
|
| 1978 |
Limbird LE, Lefkowitz RJ. Agonist induced increase in apparent β-adrenergic receptor size Federation Proceedings. 37: No.718. |
0.497 |
|
| 1977 |
Limbird LE, Lefkowitz RJ. Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. The Journal of Biological Chemistry. 252: 799-802. PMID 833154 |
0.562 |
|
| 1977 |
Limbird LE, Lefkowitz RJ. Separation of β-adrenergic receptors (βAR) from adenylate cyclase (AC) Federation Proceedings. 36: No.2437. |
0.327 |
|
| 1976 |
Limbird LE, Lefkowitz RJ. Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. Molecular Pharmacology. 12: 559-67. PMID 958206 |
0.55 |
|
| 1976 |
Limbird LE, Lefkowitz RJ. Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. The Journal of Biological Chemistry. 251: 5007-14. PMID 956174 |
0.536 |
|
| 1976 |
Lefkowitz RJ, Mukherjee C, Limbird LE, Caron MG, Williams LT, Alexander RW, Mickey JV, Tate R. Regulation of adenylate cyclase coupled beta-adrenergic receptors. Recent Progress in Hormone Research. 32: 597-632. PMID 785560 |
0.623 |
|
| 1976 |
Lefkowitz RJ, Limbird LE, Mukherjee C, Caron MG. The beta-adrenergic receptor and adenylate cyclase. Biochimica Et Biophysica Acta. 457: 1-39. PMID 769837 DOI: 10.1016/0304-4157(76)90012-5 |
0.631 |
|
| 1976 |
Lefkowitz RJ, Limbird LE. Techniques for the study of the biochemical basis of drug action. Progress in Cardiovascular Diseases. 18: 309-21. PMID 737 DOI: 10.1016/0033-0620(76)90024-4 |
0.302 |
|
| 1975 |
Limbird LE, Meyts PD, Lefkowitz RJ. Beta-adrenergic receptors: evidence for negative cooperativity. Biochemical and Biophysical Research Communications. 64: 1160-8. PMID 1137592 DOI: 10.1016/0006-291X(75)90815-3 |
0.518 |
|
| 1975 |
Limbird LE, Lefkowitz RJ. Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. Biochimica Et Biophysica Acta. 377: 186-96. PMID 235292 DOI: 10.1016/0005-2744(75)90299-5 |
0.389 |
|
| 1975 |
Limbird L, Lefkowitz R. Effects of membrane perturbation on β adrenergic receptor binding and adenylate cyclase activation Federation Proceedings. 34: No.643. |
0.324 |
|
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