Brian K. Kobilka - Publications

Affiliations: 
Molecular & Cellular Physiology Stanford University, Palo Alto, CA 
Area:
Adrenergic receptors
Website:
http://med.stanford.edu/kobilkalab/index.html

277 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sadaf A, Ramos M, Mortensen JS, Du Y, Bae HE, Munk CF, Hariharan P, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS. Conformationally restricted monosaccharide-cored glycoside amphiphiles: the effect of detergent head group variation on membrane protein stability. Acs Chemical Biology. PMID 31305987 DOI: 10.1021/acschembio.9b00166  0.52
2019 Chae PS, Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK. Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31243822 DOI: 10.1002/chem.201902468  0.64
2019 Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Conformational transitions of a neurotensin receptor 1-G complex. Nature. PMID 31243364 DOI: 10.1038/s41586-019-1337-6  0.64
2019 Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Maeda S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK. Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy. Molecular Cell. PMID 31103421 DOI: 10.1016/j.molcel.2019.04.028  0.48
2019 Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixà-González R, Mathiesen JM, Hildebrand PW, Kobilka BK. Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell. PMID 31080070 DOI: 10.1016/j.cell.2019.04.021  0.52
2019 Du Y, Duc NM, Rasmussen SGF, Hilger D, Kubiak X, Wang L, Bohon J, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee J, Chance MR, Lodowski DT, Kobilka BK, et al. Assembly of a GPCR-G Protein Complex. Cell. PMID 31080064 DOI: 10.1016/j.cell.2019.04.022  0.64
2019 Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science (New York, N.Y.). 364: 552-557. PMID 31073061 DOI: 10.1126/science.aaw5188  0.64
2019 Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Seok Chae P. Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability. Organic & Biomolecular Chemistry. PMID 31062815 DOI: 10.1039/c9ob90075f  0.52
2019 Ehsan M, Kumar A, Mortensen JS, Du Y, Hariharan P, Kumar KK, Ha B, Byrne B, Guan L, Kobilka BK, Loland CJ, Chae PS. Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study. Chemistry, An Asian Journal. PMID 30969484 DOI: 10.1002/asia.201900224  0.52
2019 Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Chae PS. Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability. Organic & Biomolecular Chemistry. PMID 30843907 DOI: 10.1039/c8ob03153c  0.52
2019 Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, ... ... Kobilka BK, et al. Author Correction: Structural insights into the activation of metabotropic glutamate receptors. Nature. PMID 30814739 DOI: 10.1038/s41586-019-0983-z  0.72
2019 Bae HE, Du Y, Hariharan P, Mortensen JS, Kumar KK, Ha B, Das M, Lee HS, Loland CJ, Guan L, Kobilka BK, Chae PS. Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability. Chemical Science. 10: 1107-1116. PMID 30774908 DOI: 10.1039/c8sc02560f  0.52
2019 Venkatakrishnan AJ, Ma AK, Fonseca R, Latorraca NR, Kelly B, Betz RM, Asawa C, Kobilka BK, Dror RO. Diverse GPCRs exhibit conserved water networks for stabilization and activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30728297 DOI: 10.1073/pnas.1809251116  0.44
2019 Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, ... ... Kobilka BK, et al. Structural insights into the activation of metabotropic glutamate receptors. Nature. PMID 30675062 DOI: 10.1038/s41586-019-0881-4  0.72
2019 Uchański T, Zögg T, Yin J, Yuan D, Wohlkönig A, Fischer B, Rosenbaum DM, Kobilka BK, Pardon E, Steyaert J. An improved yeast surface display platform for the screening of nanobody immune libraries. Scientific Reports. 9: 382. PMID 30674983 DOI: 10.1038/s41598-018-37212-3  0.64
2019 Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. PMID 30639099 DOI: 10.1016/j.cell.2018.12.005  0.88
2018 Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, et al. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell. PMID 30639101 DOI: 10.1016/j.cell.2018.11.040  0.64
2018 Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, ... Kobilka BK, et al. Publisher Correction: Structural insights into binding specificity, efficacy and bias of a βAR partial agonist. Nature Chemical Biology. PMID 30504785 DOI: 10.1038/s41589-018-0182-5  0.76
2018 Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, ... ... Kobilka BK, et al. Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 30404914 DOI: 10.1073/pnas.1813988115  0.52
2018 Hussain H, Helton T, Du Y, Mortensen JS, Hariharan P, Ehsan M, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS. A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability. The Analyst. PMID 30334564 DOI: 10.1039/c8an01408f  0.52
2018 Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, ... Kobilka BK, et al. Structural insights into binding specificity, efficacy and bias of a βAR partial agonist. Nature Chemical Biology. 14: 1059-1066. PMID 30327561 DOI: 10.1038/s41589-018-0145-x  0.76
2018 Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nature Communications. 9: 3712. PMID 30213947 DOI: 10.1038/s41467-018-06002-w  0.64
2018 Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, ... ... Kobilka BK, et al. Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature. PMID 30158697 DOI: 10.1038/s41586-018-0504-5  0.52
2018 Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK, Deisseroth K. Crystal structure of the natural anion-conducting channelrhodopsin GtACR1. Nature. PMID 30158696 DOI: 10.1038/s41586-018-0511-6  0.44
2018 Chae PS, Das M, Du Y, Mortensen JS, Hariharan P, Byrne B, Loland CJ, Guan L, Kobilka B, Lee HS. Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy. Chembiochem : a European Journal of Chemical Biology. PMID 30070754 DOI: 10.1002/cbic.201800388  0.52
2018 Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, ... ... Kobilka BK, et al. Structure of the µ-opioid receptor-G protein complex. Nature. PMID 29899455 DOI: 10.1038/s41586-018-0219-7  0.64
2018 Chae PS, Das M, Du Y, Mortensen J, Bae HE, Byrne B, Loland C, Kobilka B. An engineered lithocholate-based facial amphiphile stabilizes membrane proteins: assessing the impact of detergent customizability on protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29741269 DOI: 10.1002/chem.201801141  0.52
2018 Chae PS, Ehsan M, Das M, Stern V, Du Y, Mortensen J, Hariharan P, Byrne B, Loland C, Kobilka B, Guan L. Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability. Chembiochem : a European Journal of Chemical Biology. PMID 29660780 DOI: 10.1002/cbic.201800106  0.52
2018 Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & Biomolecular Chemistry. PMID 29564464 DOI: 10.1039/C8OB00270C  0.52
2018 Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, et al. Structure-based discovery of selective positive allosteric modulators of antagonists for the Mmuscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 29453275 DOI: 10.1073/pnas.1718037115  0.44
2018 Hilger D, Masureel M, Kobilka BK. Structure and dynamics of GPCR signaling complexes. Nature Structural & Molecular Biology. 25: 4-12. PMID 29323277 DOI: 10.1038/s41594-017-0011-7  0.52
2017 Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study. Chemical Science. 8: 8315-8324. PMID 29619178 DOI: 10.1039/c7sc03700g  0.52
2017 Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. The Analyst. PMID 28913526 DOI: 10.1039/c7an01168g  0.64
2017 Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature. PMID 28813418 DOI: 10.1038/nature23652  0.88
2017 Hussain H, Mortensen JS, Du Y, Santillan C, Ribeiro O, Go J, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Tandem malonate-based glucosides (TMGs) for membrane protein structural studies. Scientific Reports. 7: 3963. PMID 28638082 DOI: 10.1038/s41598-017-03809-3  0.52
2017 Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC. Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. Nature. PMID 28607487 DOI: 10.1038/nature22354  0.52
2017 Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G. Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature. PMID 28538729 DOI: 10.1038/nature22394  0.64
2017 Das M, Du Y, Mortensen JS, Ribeiro O, Hariharan P, Guan L, Loland CJ, Kobilka BK, Byrne B, Chae PS. Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region. Chemical Science. 8: 1169-1177. PMID 28451257 DOI: 10.1039/c6sc02981g  0.52
2017 Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, et al. Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature. PMID 28437792 DOI: 10.1038/nature22327  0.64
2017 Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell. 169: 407-421.e16. PMID 28431242 DOI: 10.1016/j.cell.2017.03.047  0.68
2017 Chae PS, Hussain H, Du Y, Tikhonova E, Mortensen J, Ribeiro O, Santillan C, Das M, Løland C, Guan L, Kobilka B, Byrne B, Ehsan M. Resorcinarene-based facial glycosides: implication of detergent flexibility on membrane protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28303608 DOI: 10.1002/chem.201605016  0.52
2017 Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. Journal of the American Chemical Society. PMID 28218862 DOI: 10.1021/jacs.6b11997  0.52
2017 Sun B, Bachhawat P, Chu ML, Wood M, Ceska T, Sands ZA, Mercier J, Lebon F, Kobilka TS, Kobilka BK. Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. Proceedings of the National Academy of Sciences of the United States of America. PMID 28167788 DOI: 10.1073/pnas.1621423114  0.72
2016 Cho KH, Hariharan P, Mortensen JS, Du Y, Nielsen AK, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS. Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length. Chembiochem : a European Journal of Chemical Biology. 17: 2334-2339. PMID 27981750 DOI: 10.1002/cbic.201600429  0.52
2016 Manglik A, Kobilka BK, Steyaert J. Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annual Review of Pharmacology and Toxicology. PMID 27959623 DOI: 10.1146/annurev-pharmtox-010716-104710  0.6
2016 Chae PS, Cho KH, Ribeiro O, Du Y, Tikhonova E, Mortensen J, Markham K, Hariharan P, Løland C, Guan L, Kobilka B, Byrne B. Mesitylene-cored glucoside amphiphiles (MGAs) for membrane protein studies: importance of alkyl chain density in detergent efficacy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27743406 DOI: 10.1002/chem.201603338  0.52
2016 Bae HE, Mortensen JS, Ribeiro O, Du Y, Ehsan M, Kobilka BK, Loland CJ, Byrne B, Chae PS. Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation. Chemical Communications (Cambridge, England). 52: 12104-12107. PMID 27711401 DOI: 10.1039/c6cc06147h  0.52
2016 Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, ... ... Kobilka BK, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 1-6. PMID 27533032 DOI: 10.1038/nature19112  0.48
2016 Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, ... Kobilka BK, et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. PMID 27409812 DOI: 10.1038/nature18636  0.44
2016 DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. PMID 27362234 DOI: 10.1038/nature18324  0.64
2016 Hussain H, Du Y, Scull NJ, Mortensen JS, Tarrasch J, Bae HE, Loland CJ, Byrne B, Kobilka BK, Chae PS. Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27072057 DOI: 10.1002/chem.201600533  0.52
2016 Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. Journal of the American Chemical Society. PMID 26966956 DOI: 10.1021/jacs.5b13233  0.52
2016 Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors. Nature. PMID 26958838 DOI: 10.1038/nature17188  0.72
2016 Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, et al. High-density grids for efficient data collection from multiple crystals. Acta Crystallographica. Section D, Structural Biology. 72: 2-11. PMID 26894529 DOI: 10.1107/S2059798315020847  0.44
2015 Dawaliby R, Trubbia C, Delporte C, Masureel M, Van Antwerpen P, Kobilka BK, Govaerts C. Allosteric regulation of G protein-coupled receptor activity by phospholipids. Nature Chemical Biology. PMID 26571351 DOI: 10.1038/nchembio.1960  0.52
2015 Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nature Communications. 6: 8857. PMID 26561004 DOI: 10.1038/ncomms9857  0.32
2015 Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, ... ... Kobilka BK, et al. Structural insights into µ-opioid receptor activation. Nature. 524: 315-21. PMID 26245379 DOI: 10.1038/nature14886  1
2015 Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. Propagation of conformational changes during μ-opioid receptor activation. Nature. 524: 375-8. PMID 26245377 DOI: 10.1038/nature14680  0.44
2015 Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nature Methods. 12: 845-51. PMID 26167642 DOI: 10.1038/nmeth.3479  0.32
2015 Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science (New York, N.Y.). 348: 1361-5. PMID 26089515 DOI: 10.1126/science.aaa5264  1
2015 Cho KH, Du Y, Scull NJ, Hariharan P, Gotfryd K, Loland CJ, Guan L, Byrne B, Kobilka BK, Chae PS. Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 10008-13. PMID 26013293 DOI: 10.1002/chem.201501083  1
2015 Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell. 161: 1101-11. PMID 25981665 DOI: 10.1016/j.cell.2015.04.043  1
2015 Duc NM, Du Y, Thorsen TS, Lee SY, Zhang C, Kato H, Kobilka BK, Chung KY. Effective application of bicelles for conformational analysis of G protein-coupled receptors by hydrogen/deuterium exchange mass spectrometry. Journal of the American Society For Mass Spectrometry. 26: 808-17. PMID 25740347 DOI: 10.1007/s13361-015-1083-4  1
2015 Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape Nature Methods. 12: 845-851. DOI: 10.1038/nmeth.3479  0.32
2014 Thorsen TS, Matt R, Weis WI, Kobilka BK. Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure (London, England : 1993). 22: 1657-1664. PMID 25450769 DOI: 10.1016/j.str.2014.08.022  1
2014 Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JL. Development and characterization of pepducins as Gs-biased allosteric agonists. The Journal of Biological Chemistry. 289: 35668-84. PMID 25395624 DOI: 10.1074/jbc.M114.618819  1
2014 Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, ... ... Kobilka BK, et al. Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proceedings of the National Academy of Sciences of the United States of America. 111: 17122-7. PMID 25362050 DOI: 10.1073/pnas.1418733111  0.44
2014 Mathiasen S, Christensen SM, Fung JJ, Rasmussen SG, Fay JF, Jorgensen SK, Veshaguri S, Farrens DL, Kiskowski M, Kobilka B, Stamou D. Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes. Nature Methods. 11: 931-4. PMID 25086504 DOI: 10.1038/nmeth.3062  1
2014 Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Kobilka BK, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/nature13430  1
2014 Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. Covalent agonists for studying G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 111: 10744-8. PMID 25006259 DOI: 10.1073/pnas.1410415111  1
2014 Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J. Muscarinic acetylcholine receptors: novel opportunities for drug development. Nature Reviews. Drug Discovery. 13: 549-60. PMID 24903776 DOI: 10.1038/nrd4295  1
2014 Kruse AC, Hu J, Kobilka BK, Wess J. Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. Current Opinion in Pharmacology. 16: 24-30. PMID 24662799 DOI: 10.1016/j.coph.2014.02.006  1
2014 Pardon E, Laeremans T, Triest S, Rasmussen SG, Wohlkönig A, Ruf A, Muyldermans S, Hol WG, Kobilka BK, Steyaert J. A general protocol for the generation of Nanobodies for structural biology. Nature Protocols. 9: 674-93. PMID 24577359 DOI: 10.1038/nprot.2014.039  1
2014 Manglik A, Kobilka B. The role of protein dynamics in GPCR function: Insights from the β2AR and rhodopsin Current Opinion in Cell Biology. 27: 136-143. PMID 24534489 DOI: 10.1016/j.ceb.2014.01.008  1
2014 Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Molecular Pharmacology. 85: 472-81. PMID 24319111 DOI: 10.1124/mol.113.089516  1
2014 Kruse AC, Li J, Hu J, Kobilka BK, Wess J. Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. Journal of Molecular Neuroscience : Mn. 53: 316-23. PMID 24068573 DOI: 10.1007/s12031-013-0127-0  1
2013 Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, ... ... Kobilka BK, et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 504: 101-6. PMID 24256733 DOI: 10.1038/nature12735  1
2013 Kruse AC, Manglik A, Kobilka BK, Weis WI. Applications of molecular replacement to G protein-coupled receptors. Acta Crystallographica. Section D, Biological Crystallography. 69: 2287-92. PMID 24189241 DOI: 10.1107/S090744491301322X  1
2013 Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH. Novel tripod amphiphiles for membrane protein analysis. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 15645-51. PMID 24123610 DOI: 10.1002/chem.201301423  1
2013 Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 502: 575-9. PMID 24056936 DOI: 10.1038/nature12572  1
2013 Kruse AC, Weiss DR, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK. Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Molecular Pharmacology. 84: 528-40. PMID 23887926 DOI: 10.1124/mol.113.087551  1
2013 Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS. The role of ligands on the equilibria between functional states of a G protein-coupled receptor. Journal of the American Chemical Society. 135: 9465-74. PMID 23721409 DOI: 10.1021/ja404305k  1
2013 Kobilka B. The structural basis of G-protein-coupled receptor signaling (nobel lecture) Angewandte Chemie - International Edition. 52: 6380-6388. PMID 23650120 DOI: 10.1002/anie.201302116  1
2013 Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, ... ... Kobilka BK, et al. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 497: 137-41. PMID 23604254 DOI: 10.1038/nature12120  1
2013 Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, ... Kobilka BK, et al. The dynamic process of β(2)-adrenergic receptor activation. Cell. 152: 532-42. PMID 23374348 DOI: 10.1016/j.cell.2013.01.008  1
2013 Chung KY, Day PW, Vélez-Ruiz G, Sunahara RK, Kobilka BK. Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach. Plos One. 8: e54942. PMID 23372797 DOI: 10.1371/journal.pone.0054942  1
2013 Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH. Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chemical Communications (Cambridge, England). 49: 2287-9. PMID 23165475 DOI: 10.1039/c2cc36844g  1
2012 Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 492: 387-92. PMID 23222541 DOI: 10.1038/nature11701  1
2012 Zocher M, Zhang C, Rasmussen SG, Kobilka BK, Müller DJ. Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 109: E3463-72. PMID 23151510 DOI: 10.1073/pnas.1210373109  1
2012 Zou Y, Weis WI, Kobilka BK. N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. Plos One. 7: e46039. PMID 23056231 DOI: 10.1371/journal.pone.0046039  1
2012 Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. Role of detergents in conformational exchange of a G protein-coupled receptor. The Journal of Biological Chemistry. 287: 36305-11. PMID 22893704 DOI: 10.1074/jbc.M112.406371  1
2012 Granier S, Kobilka B. A new era of GPCR structural and chemical biology Nature Chemical Biology. 8: 670-673. PMID 22810761 DOI: 10.1038/nchembio.1025  1
2012 Zocher M, Fung JJ, Kobilka BK, Müller DJ. Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor. Structure (London, England : 1993). 20: 1391-402. PMID 22748765 DOI: 10.1016/j.str.2012.05.010  1
2012 Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 9485-90. PMID 22730191 DOI: 10.1002/chem.201200069  1
2012 Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. Structure of the δ-opioid receptor bound to naltrindole. Nature. 485: 400-4. PMID 22596164 DOI: 10.1038/nature11111  1
2012 Shoichet BK, Kobilka BK. Structure-based drug screening for G-protein-coupled receptors. Trends in Pharmacological Sciences. 33: 268-72. PMID 22503476 DOI: 10.1016/j.tips.2012.03.007  1
2012 Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 485: 321-6. PMID 22437502 DOI: 10.1038/nature10954  1
2012 Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 482: 552-6. PMID 22358844 DOI: 10.1038/nature10867  1
2012 Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature. 482: 547-51. PMID 22278061 DOI: 10.1038/nature10753  1
2012 Bockenhauer S, Fürstenberg A, Yao XJ, Kobilka BK, Moerner WE. Anti-Brownian ELectrokinetic (ABEL) trapping of single β 2- adrenergic receptors in the absence and presence of agonist Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8228. DOI: 10.1117/12.910018  1
2012 Lefkowitz R, Kobilka B. A signal honour Chemistry World. 9: 46-49.  1
2011 Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL, Sunahara RK. Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature. 477: 611-5. PMID 21956331 DOI: 10.1038/nature10488  1
2011 Bockenhauer S, Fürstenberg A, Yao XJ, Kobilka BK, Moerner WE. Conformational dynamics of single G protein-coupled receptors in solution. The Journal of Physical Chemistry. B. 115: 13328-38. PMID 21928818 DOI: 10.1021/jp204843r  1
2011 Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, ... Kobilka BK, et al. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 16086-91. PMID 21914848 DOI: 10.1073/pnas.1113645108  1
2011 Steyaert J, Kobilka BK. Nanobody stabilization of G protein-coupled receptor conformational states. Current Opinion in Structural Biology. 21: 567-72. PMID 21782416 DOI: 10.1016/j.sbi.2011.06.011  1
2011 Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, ... ... Kobilka BK, et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature. 477: 549-55. PMID 21772288 DOI: 10.1038/nature10361  1
2011 Kobilka BK. Structural insights into adrenergic receptor function and pharmacology. Trends in Pharmacological Sciences. 32: 213-8. PMID 21414670 DOI: 10.1016/j.tips.2011.02.005  1
2011 Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, ... ... Kobilka BK, et al. Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 469: 236-40. PMID 21228876 DOI: 10.1038/nature09665  1
2011 Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, ... ... Kobilka BK, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 469: 175-80. PMID 21228869 DOI: 10.1038/nature09648  1
2010 Chae PS, Gotfryd K, Pacyna J, Miercke LJ, Rasmussen SG, Robbins RA, Rana RR, Loland CJ, Kobilka B, Stroud R, Byrne B, Gether U, Gellman SH. Tandem facial amphiphiles for membrane protein stabilization. Journal of the American Chemical Society. 132: 16750-2. PMID 21049926 DOI: 10.1021/ja1072959  1
2010 Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, ... ... Kobilka B, et al. Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature Methods. 7: 1003-8. PMID 21037590 DOI: 10.1038/nmeth.1526  1
2010 Deupi X, Kobilka BK. Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. Physiology (Bethesda, Md.). 25: 293-303. PMID 20940434 DOI: 10.1152/physiol.00002.2010  1
2010 Kenakin T, Agnati LF, Caron M, Fredholm B, Guidoli D, Kobilka B, Lefkowitz RW, Lohse M, Woods A, Fuxe K. International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? Journal of Receptor and Signal Transduction Research. 30: 284-6. PMID 20858022 DOI: 10.3109/10799893.2010.512438  1
2010 Chen MQ, Whittington RH, Day PW, Kobilka BK, Giovangrandi L, Kovacs GT. A device for separated and reversible co-culture of cardiomyocytes. Biotechnology Progress. 26: 1164-71. PMID 20730771 DOI: 10.1002/btpr.431  1
2010 Angelotti T, Daunt D, Shcherbakova OG, Kobilka B, Hurt CM. Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Traffic (Copenhagen, Denmark). 11: 560-78. PMID 20059747 DOI: 10.1111/j.1600-0854.2010.01033.x  1
2010 Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, ... Kobilka BK, et al. Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature. 463: 108-12. PMID 20054398 DOI: 10.1038/nature08650  1
2010 Kuszak AJ, Yao XJ, Rasmussen SGF, Kobilka BK, Sunahara RK. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles G Protein-Coupled Receptors: Structure, Signaling, and Physiology. 32-52. DOI: 10.1017/CBO9780511760334.003  1
2010 Rosenbaum DM, Rasmussen SGF, Kobilka BK. The γ2 adrenergic receptor as a model for g-protein-coupled receptor structure and activation by diffusible hormones Handbook of Cell Signaling, 2/E. 1: 163-169. DOI: 10.1016/B978-0-12-374145-5.00025-5  1
2009 Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara RK, Kobilka BK. Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. The Embo Journal. 28: 3315-28. PMID 19763081 DOI: 10.1038/emboj.2009.267  1
2009 Ratnala VR, Kobilka B. Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery Methods in Molecular Biology (Clifton, N.J.). 552: 67-77. PMID 19513642 DOI: 10.1007/978-1-60327-317-6_5  1
2009 Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara RK, Kobilka B. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proceedings of the National Academy of Sciences of the United States of America. 106: 9501-6. PMID 19470481 DOI: 10.1073/pnas.0811437106  1
2009 Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 459: 356-63. PMID 19458711 DOI: 10.1038/nature08144  1
2009 Kolb P, Rosenbaum DM, Irwin JJ, Fung JJ, Kobilka BK, Shoichet BK. Structure-based discovery of beta2-adrenergic receptor ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 6843-8. PMID 19342484 DOI: 10.1073/pnas.0812657106  1
2009 Weis WI, Rosenbaum DM, Rasmussen SGF, Choi HJ, Thian FS, Kobilka TS, Yao XJ, Day PW, Parnot C, Fung JJ, Ratnala VRP, Kobilka BK, Cherezov V, Hanson MA, Kuhn P, et al. Crystal structures of the β2-adrenergic receptor Nato Science For Peace and Security Series a: Chemistry and Biology. 217-230. DOI: 10.1007/978-90-481-2339-1-14  1
2009 Bockenhauer S, Fürstenberg A, Wang Q, Bokoch M, Yao XJ, DeVree B, Sunahara RK, Kobilka BK, Moerner WE. Anti-Brownian ELectrokinetic (ABEL) trapping of single high density lipoprotein (HDL) particles Optics Infobase Conference Papers 1
2009 Weis WI, Rosenbaum DM, Rasmussen SGF, Choi HJ, Thian FS, Kobilka TS, Yao XJ, Day PW, Parnot C, Fung JJ, Ratnala VRP, Kobilka BK, Cherezov V, Hanson MA, Kuhn P, et al. Crystal structures of the β2-adrenergic receptor Nato Science For Peace and Security Series a: Chemistry and Biology. 217-230.  1
2008 Weis WI, Kobilka BK. Structural insights into G-protein-coupled receptor activation. Current Opinion in Structural Biology. 18: 734-40. PMID 18957321 DOI: 10.1016/j.sbi.2008.09.010  1
2008 Kobilka B, Schertler GFX. New G-protein-coupled receptor crystal structures: insights and limitations Trends in Pharmacological Sciences. 29: 79-83. PMID 18194818 DOI: 10.1016/j.tips.2007.11.009  1
2008 Richter W, Day P, Agrawal R, Bruss MD, Granier S, Wang YL, Rasmussen SGF, Horner K, Wang P, Lei T, Patterson AJ, Kobilka B, Conti M. Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4 Embo Journal. 27: 384-393. PMID 18188154 DOI: 10.1038/sj.emboj.7601968  1
2007 Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (New York, N.Y.). 318: 1258-65. PMID 17962520 DOI: 10.1126/science.1150577  1
2007 Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (New York, N.Y.). 318: 1266-73. PMID 17962519 DOI: 10.1126/science.1150609  1
2007 Day PW, Rasmussen SG, Parnot C, Fung JJ, Masood A, Kobilka TS, Yao XJ, Choi HJ, Weis WI, Rohrer DK, Kobilka BK. A monoclonal antibody for G protein-coupled receptor crystallography. Nature Methods. 4: 927-9. PMID 17952087 DOI: 10.1038/nmeth1112  1
2007 Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature. 450: 383-7. PMID 17952055 DOI: 10.1038/nature06325  1
2007 Deupi X, Kobilka B. Activation of G Protein-Coupled Receptors Advances in Protein Chemistry. 74: 137-166. PMID 17854657 DOI: 10.1016/S0065-3233(07)74004-4  1
2007 Kobilka BK, Deupi X. Conformational complexity of G-protein-coupled receptors. Trends in Pharmacological Sciences. 28: 397-406. PMID 17629961 DOI: 10.1016/j.tips.2007.06.003  1
2007 Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y. N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Molecular Pharmacology. 72: 429-39. PMID 17510209 DOI: 10.1124/mol.107.037747  1
2007 Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proceedings of the National Academy of Sciences of the United States of America. 104: 7682-7. PMID 17452637 DOI: 10.1073/pnas.0611448104  1
2007 Granier S, Kim S, Shafer AM, Ratnala VR, Fung JJ, Zare RN, Kobilka B. Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies. The Journal of Biological Chemistry. 282: 13895-905. PMID 17347144 DOI: 10.1074/jbc.M611904200  1
2007 Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. The Journal of Cell Biology. 176: 521-33. PMID 17296797 DOI: 10.1083/jcb.200604167  1
2007 Huang B, Wu H, Bhaya D, Grossman A, Granier S, Kobilka BK, Zare RN. Counting low-copy number proteins in a single cell. Science (New York, N.Y.). 315: 81-4. PMID 17204646 DOI: 10.1126/science.1133992  1
2007 Kobilka BK. G protein coupled receptor structure and activation. Biochimica Et Biophysica Acta. 1768: 794-807. PMID 17188232 DOI: 10.1016/j.bbamem.2006.10.021  1
2007 Sun Y, Huang J, Xiang Y, Bastepe M, Jüppner H, Kobilka BK, Zhang JJ, Huang XY. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. The Embo Journal. 26: 53-64. PMID 17170700 DOI: 10.1038/sj.emboj.7601502  1
2007 Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/jpet.106.104463  1
2006 Day P, Kobilka B. PDZ-domain arrays for identifying components of GPCR signaling complexes Trends in Pharmacological Sciences. 27: 509-511. PMID 16904197 DOI: 10.1016/j.tips.2006.08.003  1
2006 Yao X, Parnot C, Deupi X, Ratnala VR, Swaminath G, Farrens D, Kobilka B. Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nature Chemical Biology. 2: 417-22. PMID 16799554 DOI: 10.1038/nchembio801  1
2006 Brum PC, Hurt CM, Shcherbakova OG, Kobilka B, Angelotti T. Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons. Neuropharmacology. 51: 397-413. PMID 16750543 DOI: 10.1016/j.neuropharm.2006.03.032  1
2006 Huang B, Wu H, Kim S, Kobilka BK, Zare RN. Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization. Lab On a Chip. 6: 369-73. PMID 16511619 DOI: 10.1039/b515840k  1
2006 Ecker PM, Lin CC, Powers J, Kobilka BK, Dubin AM, Bernstein D. Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability. American Journal of Physiology. Heart and Circulatory Physiology. 290: H192-9. PMID 16113068 DOI: 10.1152/ajpheart.00032.2005  1
2005 Bernstein D, Fajardo G, Zhao M, Urashima T, Powers J, Berry G, Kobilka BK. Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2441-9. PMID 16040722 DOI: 10.1152/ajpheart.00005.2005  1
2005 Yao Z, Kobilka B. Using synthetic lipids to stabilize purified β2 adrenoceptor in detergent micelles Analytical Biochemistry. 343: 344-346. PMID 16005425 DOI: 10.1016/j.ab.2005.05.002  1
2005 Trester-Zedlitz M, Burlingame A, Kobilka B, von Zastrow M. Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry. 44: 6133-43. PMID 15835901 DOI: 10.1021/bi0475469  1
2005 Swaminath G, Deupi X, Lee TW, Zhu W, Thian FS, Kobilka TS, Kobilka B. Probing the β2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists Journal of Biological Chemistry. 280: 22165-22171. PMID 15817484 DOI: 10.1074/jbc.M502352200  1
2005 Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff EY, Jan LY. A fluorescent probe designed for studying protein conformational change. Proceedings of the National Academy of Sciences of the United States of America. 102: 965-70. PMID 15657131 DOI: 10.1073/pnas.0409469102  1
2005 Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B. Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 102: 909-14. PMID 15644445 DOI: 10.1073/pnas.0405263102  1
2004 Swaminath G, Xiang Y, Lee TW, Steenhuis J, Parnot C, Kobilka BK. Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. The Journal of Biological Chemistry. 279: 686-91. PMID 14559905 DOI: 10.1074/jbc.M310888200  1
2003 Chakir K, Xiang Y, Yang D, Zhang SJ, Cheng H, Kobilka BK, Xiao RP. The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. Molecular Pharmacology. 64: 1048-58. PMID 14573753 DOI: 10.1124/mol.64.5.1048  1
2003 McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of Clinical Investigation. 112: 619-26. PMID 12925702 DOI: 10.1172/JCI18193  1
2003 Xiang Y, Kobilka BK. Myocyte adrenoceptor signaling pathways. Science (New York, N.Y.). 300: 1530-2. PMID 12791980 DOI: 10.1126/science.1079206  1
2003 Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. The Journal of Clinical Investigation. 111: 617-25. PMID 12618516 DOI: 10.1172/JCI16326  1
2002 Kobilka BK. Agonist-induced conformational changes in the beta2 adrenergic receptor. The Journal of Peptide Research : Official Journal of the American Peptide Society. 60: 317-21. PMID 12464109 DOI: 10.1034/j.1399-3011.2002.21062.x  1
2002 Seifert R, Wenzel-Seifert K, Arthur JM, Jose PO, Kobilka BK. Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein. Biochemical and Biophysical Research Communications. 298: 824-8. PMID 12419329 DOI: 10.1016/S0006-291X(02)02569-X  1
2002 Neumann L, Wohland T, Whelan RJ, Zare RN, Kobilka BK. Functional immobilization of a ligand-activated G-protein-coupled receptor. Chembiochem : a European Journal of Chemical Biology. 3: 993-8. PMID 12362365 DOI: 10.1002/1439-7633(20021004)3:10<993::AID-CBIC993>3.0.CO;2-Y  1
2002 Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8771-7. PMID 12351753  1
2002 Whelan RJ, Wohland T, Neumann L, Huang B, Kobilka BK, Zare RN. Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensor. Analytical Chemistry. 74: 4570-6. PMID 12236371 DOI: 10.1021/ac025669y  1
2002 Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proceedings of the National Academy of Sciences of the United States of America. 99: 12471-6. PMID 12205290 DOI: 10.1073/pnas.122368499  1
2002 Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (New York, N.Y.). 297: 843-5. PMID 12161655 DOI: 10.1126/science.1073160  1
2002 Lähdesmäki J, Sallinen J, MacDonald E, Kobilka BK, Fagerholm V, Scheinin M. Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice. Neuroscience. 113: 289-99. PMID 12127086 DOI: 10.1016/S0306-4522(02)00185-9  1
2002 Hinkle RT, Hodge KM, Cody DB, Sheldon RJ, Kobilka BK, Isfort RJ. Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor. Muscle & Nerve. 25: 729-34. PMID 11994968 DOI: 10.1002/mus.10092  1
2002 Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M. Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology. 96: 367-74. PMID 11818770  1
2002 Kobilka BK, Gether U. Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor. Methods in Enzymology. 343: 170-82. PMID 11665566 DOI: 10.1016/S0076-6879(02)43134-5  1
2001 Chruscinski A, Brede ME, Meinel L, Lohse MJ, Kobilka BK, Hein L. Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Molecular Pharmacology. 60: 955-62. PMID 11641423  1
2001 Aravanis AM, DeBusschere BD, Chruscinski AJ, Gilchrist KH, Kobilka BK, Kovacs GT. A genetically engineered cell-based biosensor for functional classification of agents. Biosensors & Bioelectronics. 16: 571-7. PMID 11544051 DOI: 10.1016/S0956-5663(01)00171-3  1
2001 Peleg G, Ghanouni P, Kobilka BK, Zare RN. Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 8469-74. PMID 11438704 DOI: 10.1073/pnas.151239698  1
2001 Seifert R, Wenzel-Seifert K, Gether U, Kobilka BK. Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations. The Journal of Pharmacology and Experimental Therapeutics. 297: 1218-26. PMID 11356949  1
2001 Ghanouni P, Steenhuis JJ, Farrens DL, Kobilka BK. Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 98: 5997-6002. PMID 11353823 DOI: 10.1073/pnas.101126198  1
2001 Ghanouni P, Gryczynski Z, Steenhuis JJ, Lee TW, Farrens DL, Lakowicz JR, Kobilka BK. Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. The Journal of Biological Chemistry. 276: 24433-6. PMID 11320077 DOI: 10.1074/jbc.C100162200  1
2001 Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 98: 1607-12. PMID 11171998 DOI: 10.1073/pnas.98.4.1607  1
2000 Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M. Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 9242-51. PMID 11125002  1
2000 Zhou YY, Yang D, Zhu WZ, Zhang SJ, Wang DJ, Rohrer DK, Devic E, Kobilka BK, Lakatta EG, Cheng H, Xiao RP. Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice. Molecular Pharmacology. 58: 887-94. PMID 11040034  1
2000 Zheng M, Zhang SJ, Zhu WZ, Ziman B, Kobilka BK, Xiao RP. beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes. The Journal of Biological Chemistry. 275: 40635-40. PMID 11018034 DOI: 10.1074/jbc.M006325200  1
2000 Zhou YY, Wang SQ, Zhu WZ, Chruscinski A, Kobilka BK, Ziman B, Wang S, Lakatta EG, Cheng H, Xiao RP. Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. American Journal of Physiology. Heart and Circulatory Physiology. 279: H429-36. PMID 10899083  1
2000 Hoare SRJ, Seifert R, Wenzel-Seifert K, Kobilka BK. G-protein-coupled receptors: What limits high-affinity agonist binding? [1] (multiple letters) Trends in Pharmacological Sciences. 21: 82-84. PMID 10689358 DOI: 10.1016/S0165-6147(99)01426-1  1
2000 Ghanouni P, Schambye H, Seifert R, Lee TW, Rasmussen SG, Gether U, Kobilka BK. The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation. The Journal of Biological Chemistry. 275: 3121-7. PMID 10652295 DOI: 10.1074/jbc.275.5.3121  1
1999 Hein L, Altman JD, Kobilka BK. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature. 402: 181-4. PMID 10647009 DOI: 10.1038/46040  1
1999 Lee TW, Seifert R, Guan X, Kobilka BK. Restricting the mobility of Gs alpha: impact on receptor and effector coupling. Biochemistry. 38: 13801-9. PMID 10529225 DOI: 10.1021/bi9908282  1
1999 Sallinen J, Haapalinna A, MacDonald E, Viitamaa T, Lähdesmäki J, Rybnikova E, Pelto-Huikko M, Kobilka BK, Scheinin M. Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels. Molecular Psychiatry. 4: 443-52. PMID 10523817  1
1999 Seifert R, Wenzel-Seifert K, Kobilka BK. GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling. Trends in Pharmacological Sciences. 20: 383-9. PMID 10462762 DOI: 10.1016/S0165-6147(99)01368-1  1
1999 Seifert R, Gether U, Wenzel-Seifert K, Kobilka BK. Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations. Molecular Pharmacology. 56: 348-58. PMID 10419554  1
1999 Hein L, Limbird LE, Eglen RM, Kobilka BK. Gene substitution/knockout to delineate the role of alpha 2-adrenoceptor subtypes in mediating central effects of catecholamines and imidazolines. Annals of the New York Academy of Sciences. 881: 265-71. PMID 10415924 DOI: 10.1111/j.1749-6632.1999.tb09368.x  1
1999 Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Molecular Pharmacology. 56: 154-61. PMID 10385696  1
1999 Rohrer DK, Chruscinski A, Schauble EH, Bernstein D, Kobilka BK. Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors. The Journal of Biological Chemistry. 274: 16701-8. PMID 10358009 DOI: 10.1074/jbc.274.24.16701  1
1999 Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK. Targeted disruption of the beta2 adrenergic receptor gene. The Journal of Biological Chemistry. 274: 16694-700. PMID 10358008 DOI: 10.1074/jbc.274.24.16694  1
1999 Björklund M, Sirviö J, Sallinen J, Scheinin M, Kobilka BK, Riekkinen P. Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns. Neuroscience. 88: 1187-98. PMID 10336129 DOI: 10.1016/S0306-4522(98)00306-6  1
1999 Seifert R, Wenzel-Seifert K, Gether U, Lam VT, Kobilka BK. Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein. European Journal of Biochemistry / Febs. 260: 661-6. PMID 10102993 DOI: 10.1046/j.1432-1327.1999.00161.x  1
1998 Rohrer DK, Schauble EH, Desai KH, Kobilka BK, Bernstein D. Alterations in dynamic heart rate control in the β-adrenergic receptor knockout mouse. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1184-H1193. PMID 29585980 DOI: 10.1152/ajpheart.1998.274.4.H1184  0.36
1998 Björklund M, Sirviö J, Puoliväli J, Sallinen J, Jäkälä P, Scheinin M, Kobilka BK, Riekkinen P. Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies. Molecular Pharmacology. 54: 569-76. PMID 9730916  1
1998 Wenzel-Seifert K, Lee TW, Seifert R, Kobilka BK. Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity. The Biochemical Journal. 334: 519-24. PMID 9729456  1
1998 Seifert R, Lee TW, Lam VT, Kobilka BK. Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein. European Journal of Biochemistry / Febs. 255: 369-82. PMID 9716378 DOI: 10.1046/j.1432-1327.1998.2550369.x  1
1998 Sallinen J, Haapalinna A, Viitamaa T, Kobilka BK, Scheinin M. D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype. Neuroscience. 86: 959-65. PMID 9692731 DOI: 10.1016/S0306-4522(98)00100-6  1
1998 Gether U, Kobilka BK. G protein-coupled receptors. II. Mechanism of agonist activation. The Journal of Biological Chemistry. 273: 17979-82. PMID 9660746 DOI: 10.1074/jbc.273.29.17979  1
1998 Rohrer DK, Kobilka BK. Insights from in vivo modification of adrenergic receptor gene expression. Annual Review of Pharmacology and Toxicology. 38: 351-73. PMID 9597159 DOI: 10.1146/annurev.pharmtox.38.1.351  1
1998 Rohrer DK, Schauble EH, Desai KH, Kobilka BK, Bernstein D. Alterations in dynamic heart rate control in the beta 1-adrenergic receptor knockout mouse. The American Journal of Physiology. 274: H1184-93. PMID 9575921  1
1998 Seifert R, Wenzel-Seifert K, Lee TW, Gether U, Sanders-Bush E, Kobilka BK. Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. The Journal of Biological Chemistry. 273: 5109-16. PMID 9556548  1
1998 Sallinen J, Haapalinna A, Viitamaa T, Kobilka BK, Scheinin M. Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3035-42. PMID 9526020  1
1998 Seifert R, Wenzel-Seifert K, Lee TW, Gether U, Sanders-Bush E, Kobilka BK. Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. The Journal of Biological Chemistry. 273: 5109-16. PMID 9478963 DOI: 10.1074/jbc.273.9.5109  1
1998 Rohrer DK, Kobilka BK. G protein-coupled receptors: functional and mechanistic insights through altered gene expression. Physiological Reviews. 78: 35-52. PMID 9457168  1
1998 Rohrer DK, Bernstein D, Chruscinski A, Desai KH, Schauble E, Kobilka BK. The developmental and physiological consequences of disrupting genes encoding beta 1 and beta 2 adrenoceptors. Advances in Pharmacology (San Diego, Calif.). 42: 499-501. PMID 9327949  1
1998 Kobilka BK, Gether U. Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by fluorescence spectroscopy. Advances in Pharmacology (San Diego, Calif.). 42: 470-3. PMID 9327941  1
1998 Wenzel-Seifert K, Lee TW, Seifert R, Kobilka BK. Restricting mobility of G(s)α relative to the β2-adrenoceptor enhances adenylate cyclase activity by reducing G(s)α GTPase activity Biochemical Journal. 334: 519-524.  1
1998 Rohrer DK, Schauble EH, Desai KH, Kobilka BK, Bernstein D. Alterations in dynamic heart rate control in the β1-adrenergic receptor knockout mouse American Journal of Physiology - Heart and Circulatory Physiology. 43: H1184-H1193.  1
1998 Hein L, Spindler M, Altman JD, Kobilka BK. Alpha-2-adrenoceptor subtypes: Distribution and function Pharmacology and Toxicology, Supplement. 83: 26-28.  1
1997 Hein L, Kobilka BK. Adrenergic Receptors From Molecular Structure to in vivo function. Trends in Cardiovascular Medicine. 7: 137-45. PMID 21235877 DOI: 10.1016/S1050-1738(97)00034-0  1
1997 Parola AL, Lin S, Kobilka BK. Site-specific fluorescence labeling of the beta2 adrenergic receptor amino terminus. Analytical Biochemistry. 254: 88-95. PMID 9398350 DOI: 10.1006/abio.1997.2361  1
1997 Gether U, Lin S, Ghanouni P, Ballesteros JA, Weinstein H, Kobilka BK. Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. The Embo Journal. 16: 6737-47. PMID 9362488 DOI: 10.1093/emboj/16.22.6737  1
1997 Hein L, Meinel L, Pratt RE, Dzau VJ, Kobilka BK. Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. Molecular Endocrinology (Baltimore, Md.). 11: 1266-77. PMID 9259318 DOI: 10.1210/mend.11.9.9975  1
1997 Klein U, Ramirez MT, Kobilka BK, von Zastrow M. A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B. The Journal of Biological Chemistry. 272: 19099-102. PMID 9235896 DOI: 10.1074/jbc.272.31.19099  1
1997 MacDonald E, Kobilka BK, Scheinin M. Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. Trends in Pharmacological Sciences. 18: 211-9. PMID 9227000 DOI: 10.1016/S0165-6147(97)01063-8  1
1997 Hein L, Stevens ME, Barsh GS, Pratt RE, Kobilka BK, Dzau VJ. Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proceedings of the National Academy of Sciences of the United States of America. 94: 6391-6. PMID 9177228 DOI: 10.1073/pnas.94.12.6391  1
1997 Daunt DA, Hurt C, Hein L, Kallio J, Feng F, Kobilka BK. Subtype-specific intracellular trafficking of alpha2-adrenergic receptors. Molecular Pharmacology. 51: 711-20. PMID 9145909  1
1997 Desai KH, Sato R, Schauble E, Barsh GS, Kobilka BK, Bernstein D. Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. The American Journal of Physiology. 272: H1053-61. PMID 9124413  1
1997 Sallinen J, Link RE, Haapalinna A, Viitamaa T, Kulatunga M, Sjöholm B, Macdonald E, Pelto-Huikko M, Leino T, Barsh GS, Kobilka BK, Scheinin M. Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Molecular Pharmacology. 51: 36-46. PMID 9016344  1
1997 Gether U, Ballesteros JA, Seifert R, Sanders-Bush E, Weinstein H, Kobilka BK. Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility. The Journal of Biological Chemistry. 272: 2587-90. PMID 9006889 DOI: 10.1074/jbc.272.5.2587  1
1997 Rohrer DK, Bernstein D, Chruscinski A, Desai KH, Schauble E, Kobilka BK. The Developmental and Physiological Consequences of Disrupting Genes Encoding β1 and β2 Adrenoceptors Advances in Pharmacology. 42: 499-501. DOI: 10.1016/S1054-3589(08)60798-X  1
1997 Kobilka BK, Gether U. Examination of Ligand-Induced Conformational Changes in the β2-Adrenergic Receptor by Fluorescence Spectroscopy Advances in Pharmacology. 42: 470-473. DOI: 10.1016/S1054-3589(08)60790-5  1
1996 Mostafapour S, Kobilka BK, von Zastrow M. Pharmacological sequestration of a chimeric beta 3/beta 2 adrenergic receptor occurs without a corresponding amount of receptor internalization. Receptors & Signal Transduction. 6: 151-63. PMID 9259050  1
1996 Lin S, Gether U, Kobilka BK. Ligand stabilization of the beta 2 adrenergic receptor: effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy. Biochemistry. 35: 14445-51. PMID 8931540 DOI: 10.1021/bi961619+  1
1996 Kudo M, Osuga Y, Kobilka BK, Hsueh AJ. Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. The Journal of Biological Chemistry. 271: 22470-8. PMID 8798412 DOI: 10.1074/jbc.271.37.22470  1
1996 Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DP, Barsh GS, Bernstein D, Kobilka BK. Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proceedings of the National Academy of Sciences of the United States of America. 93: 7375-80. PMID 8693001 DOI: 10.1073/pnas.93.14.7375  1
1996 Link RE, Desai K, Hein L, Stevens ME, Chruscinski A, Bernstein D, Barsh GS, Kobilka BK. Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science (New York, N.Y.). 273: 803-5. PMID 8670422  1
1996 Mizobe T, Maze M, Lam V, Suryanarayana S, Kobilka BK. Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin. The Journal of Biological Chemistry. 271: 2387-9. PMID 8576196  1
1996 Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Correction: Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice (Nature (1995) 377 (744-747)) Nature. 380: 366. DOI: 10.1038/380366a0  1
1996 Lin S, Gether U, Kobilka BK. Ligand stabilization of the β2 adrenergic receptor: Effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy Biochemistry. 35: X-14451.  1
1995 Kobilka BK. Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor. Analytical Biochemistry. 231: 269-71. PMID 8678314 DOI: 10.1006/abio.1995.1533  1
1995 Dzau VJ, Gibbons GH, Kobilka BK, Lawn RM, Pratt RE. Genetic models of human vascular disease. Circulation. 91: 521-31. PMID 7805258  1
1995 Link RE, Stevens MS, Kulatunga M, Scheinin M, Barsh GS, Kobilka BK. Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. Molecular Pharmacology. 48: 48-55. PMID 7623774  1
1995 Hein L, Kobilka BK. Adrenergic receptor signal transduction and regulation. Neuropharmacology. 34: 357-66. PMID 7566466 DOI: 10.1016/0028-3908(95)00018-2  1
1995 Gether U, Lin S, Kobilka BK. Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. The Journal of Biological Chemistry. 270: 28268-75. PMID 7499324  1
1995 Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 377: 744-7. PMID 7477266 DOI: 10.1038/377744a0  1
1995 Suryanarayana S, Kobilka BK. [15] Receptor chimers Methods in Neurosciences. 25: 278-301. DOI: 10.1016/S1043-9471(05)80045-X  1
1995 Kobilka BK. Adrenergic receptor structure and activation Pharmacology Communications. 6: 119-124.  1
1994 Parola AL, Kobilka BK. The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis. The Journal of Biological Chemistry. 269: 4497-505. PMID 8308019  1
1994 Hein L, Ishii K, Coughlin SR, Kobilka BK. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. The Journal of Biological Chemistry. 269: 27719-26. PMID 7961693  1
1994 von Zastrow M, Kobilka BK. Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization. The Journal of Biological Chemistry. 269: 18448-52. PMID 7518433  1
1993 Jasper JR, Link RE, Chruscinski AJ, Kobilka BK, Bernstein D. Primary structure of the mouse beta 1-adrenergic receptor gene. Biochimica Et Biophysica Acta. 1178: 307-9. PMID 8395893 DOI: 10.1016/0167-4889(93)90209-8  1
1993 Link RE, Kobilka BK, Barsh GS. Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 4: 650-5. PMID 8281014 DOI: 10.1007/BF00360902  1
1993 Suryanarayana S, Kobilka BK. Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand-binding specificity. Molecular Pharmacology. 44: 111-4. PMID 8101966  1
1992 Sasamura H, Hein L, Krieger JE, Pratt RE, Kobilka BK, Dzau VJ. Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochemical and Biophysical Research Communications. 185: 253-9. PMID 1599461 DOI: 10.1016/S0006-291X(05)80983-0  1
1992 von Zastrow M, Kobilka BK. Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. The Journal of Biological Chemistry. 267: 3530-8. PMID 1371121  1
1992 Chruscinski AJ, Link RE, Daunt DA, Barsh GS, Kobilka BK. Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor. Biochemical and Biophysical Research Communications. 186: 1280-7. PMID 1354956 DOI: 10.1016/S0006-291X(05)81544-X  1
1992 Guan XM, Peroutka SJ, Kobilka BK. Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors. Molecular Pharmacology. 41: 695-8. PMID 1349154  1
1992 Guan XM, Kobilka TS, Kobilka BK. Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide. The Journal of Biological Chemistry. 267: 21995-8. PMID 1331042  1
1992 Suryanarayana S, von Zastrow M, Kobilka BK. Identification of intramolecular interactions in adrenergic receptors. The Journal of Biological Chemistry. 267: 21991-4. PMID 1331041  1
1991 Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK. A single point mutation in the seventh hydrophobic domain of the alpha 2-adrenergic receptor changes antagonist binding specificity to that of a beta receptor. Transactions of the Association of American Physicians. 104: 62-8. PMID 1688262  1
1991 Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK. A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists. The Journal of Biological Chemistry. 266: 15488-92. PMID 1678390  1
1991 Suryanarayana S, Kobilka BK. Construction and expression of chimeric receptors to understand the structure-function relationships in adrenergic receptors Methods. 3: 193-204. DOI: 10.1016/S1046-2023(05)80172-0  1
1990 Cotecchia S, Kobilka BK, Daniel KW, Nolan RD, Lapetina EY, Caron MG, Lefkowitz RJ, Regan JW. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. The Journal of Biological Chemistry. 265: 63-9. PMID 2152928  1
1990 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. Cell Regulation. 1: 445-51. PMID 1981685  1
1990 Kobilka BK. The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system. The Journal of Biological Chemistry. 265: 7610-8. PMID 1692024  1
1990 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. α2-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene Molecular Biology of the Cell. 1: 445-451.  1
1989 Lefkowitz RJ, Kobilka BK, Caron MG. The new biology of drug receptors. Biochemical Pharmacology. 38: 2941-8. PMID 2551299 DOI: 10.1016/0006-2952(89)90001-4  1
1989 Catterall WA, Kobilka BK, Kobilka TS, Daniels KW, Regan JW, Caran MG, Lefkowitz RJ. Analysis of ligand binding specificity of receptor chimeras Science. 243: 236-237. PMID 2536189  1
1989 Bouvier M, Collins S, O'Dowd BF, Campbell PT, de Blasi A, Kobilka BK, MacGregor C, Irons GP, Caron MG, Lefkowitz RJ. Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. The Journal of Biological Chemistry. 264: 16786-92. PMID 2476447  1
1988 Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature. 335: 358-60. PMID 3138543 DOI: 10.1038/335358a0  1
1988 Lefkowitz RJ, Kobilka BK, Benovic JL, Bouvier M, Cotecchia S, Hausdorff WP, Dohlman HG, Regan JW, Caron MG. Molecular biology of adrenergic receptors. Cold Spring Harbor Symposia On Quantitative Biology. 53: 507-14. PMID 2855490  1
1988 Cotecchia S, Schwinn DA, Randall RR, Lefkowitz RJ, Caron MG, Kobilka BK. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 85: 7159-63. PMID 2845398  1
1988 Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proceedings of the National Academy of Sciences of the United States of America. 85: 6301-5. PMID 2842764  1
1988 Caron MG, Kobilka BK, Frielle T, Bolanowski MA, Benovic JL, Lefkowitz RJ. Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. Journal of Receptor Research. 8: 7-21. PMID 2838630 DOI: 10.3109/10799898809048975  1
1988 Kobilka BK, Kobilka TS, Daniel K, Regan JW, Caron MG, Lefkowitz RJ. Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (New York, N.Y.). 240: 1310-6. PMID 2836950  1
1988 Bouvier M, Hausdorff WP, De Blasi A, O'Dowd BF, Kobilka BK, Caron MG, Lefkowitz RJ. Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature. 333: 370-3. PMID 2836733 DOI: 10.1038/333370a0  1
1988 Bouvier M, Hnatowich M, Collins S, Kobilka BK, Deblasi A, Lefkowitz RJ, Caron MG. Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. Molecular Pharmacology. 33: 133-9. PMID 2828911  1
1987 Kobilka BK, Frielle T, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, Caron MG. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature. 329: 75-9. PMID 3041227 DOI: 10.1038/329075a0  1
1987 Kobilka BK, Frielle T, Dohlman HG, Bolanowski MA, Dixon RA, Keller P, Caron MG, Lefkowitz RJ. Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. The Journal of Biological Chemistry. 262: 7321-7. PMID 3034889  1
1987 Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proceedings of the National Academy of Sciences of the United States of America. 84: 46-50. PMID 3025863 DOI: 10.1073/pnas.84.1.46  1
1987 Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning of the cDNA for the human beta 1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 84: 7920-4. PMID 2825170  1
1987 Kobilka BK, MacGregor C, Daniel K, Kobilka TS, Caron MG, Lefkowitz RJ. Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. The Journal of Biological Chemistry. 262: 15796-802. PMID 2824467  1
1987 Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (New York, N.Y.). 238: 650-6. PMID 2823383  1
1986 Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, Bolanowski MA, Bennett CD, Rands E, Diehl RE, Mumford RA, Slater EE, Sigal IS, Caron MG, Lefkowitz RJ, et al. Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature. 321: 75-9. PMID 3010132 DOI: 10.1038/321075a0  1
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