Robert Raffa - Publications

Affiliations: 
Temple University, Philadelphia, PA, United States 
Area:
Pharmaceutical Chemistry, Biochemistry

23/393 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Christoph T, Raffa R, De Vry J, Schröder W. Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model. Pharmacology Research & Perspectives. 6: e00444. PMID 30519474 DOI: 10.1002/Prp2.444  0.405
2016 Pergolizzi JV, Raffa RB, LeQuang JA. The Centers for Disease Control and Prevention opioid guidelines: potential for unintended consequences and will they be abused? Journal of Clinical Pharmacy and Therapeutics. 41: 592-593. PMID 27576604 DOI: 10.1111/Jcpt.12444  0.317
2015 Nguyen V, Raffa RB, Taylor R, Pergolizzi JV. The role of abuse-deterrent formulations in countering opioid misuse and abuse. Journal of Clinical Pharmacy and Therapeutics. PMID 26595258 DOI: 10.1111/Jcpt.12337  0.337
2014 Tallarida CS, Egan E, Alejo GD, Raffa R, Tallarida RJ, Rawls SM. Levamisole and cocaine synergism: a prevalent adulterant enhances cocaine's action in vivo. Neuropharmacology. 79: 590-5. PMID 24440755 DOI: 10.1016/J.Neuropharm.2014.01.002  0.365
2008 Rawls SM, Gerber K, Ding Z, Roth C, Raffa RB. Agmatine: identification and inhibition of methamphetamine, kappa opioid, and cannabinoid withdrawal in planarians. Synapse (New York, N.Y.). 62: 927-34. PMID 18792993 DOI: 10.1002/Syn.20571  0.342
2008 Raffa RB, Stagliano GW, Ross G, Powell JA, Phillips AG, Ding Z, Rawls SM. The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'. Brain Research. 1193: 51-6. PMID 18178175 DOI: 10.1016/J.Brainres.2007.12.001  0.779
2007 Raffa RB, Cavallo F, Capasso A. Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists. European Journal of Pharmacology. 564: 88-93. PMID 17368613 DOI: 10.1016/j.ejphar.2007.02.006  0.312
2007 Raffa RB, Stagliano GW, Tallarida RJ. Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians. European Journal of Pharmacology. 556: 89-90. PMID 17141755 DOI: 10.1016/J.Ejphar.2006.10.051  0.77
2006 Raffa RB, Stagliano GW, Tallarida RJ. Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria. Brain Research. 1114: 31-5. PMID 16914122 DOI: 10.1016/J.Brainres.2006.07.037  0.784
2006 Rawls SM, Gomez T, Stagliano GW, Raffa RB. Measurement of glutamate and aspartate in Planaria. Journal of Pharmacological and Toxicological Methods. 53: 291-5. PMID 16332445 DOI: 10.1016/J.Vascn.2005.10.004  0.729
2005 Schulingkamp RJ, Aloyo V, Tallarida RJ, Raffa RB. Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats. Pharmacology. 74: 23-30. PMID 15640611 DOI: 10.1159/000083211  0.737
2005 Umeda S, Stagliano GW, Borenstein MR, Raffa RB. A reverse-phase HPLC and fluorescence detection method for measurement of 5-hydroxytryptamine (serotonin) in Planaria. Journal of Pharmacological and Toxicological Methods. 51: 73-6. PMID 15596117 DOI: 10.1016/J.Vascn.2004.07.002  0.762
2004 Spencer SD, Raffa RB. Isothermal titration calorimetric study of RNase-A kinetics (cCMP --> 3'-CMP) involving end-product inhibition. Pharmaceutical Research. 21: 1642-7. PMID 15497691 DOI: 10.1023/B:Pham.0000041460.78128.0F  0.623
2004 Umeda S, Stagliano GW, Raffa RB. Cocaine and kappa-opioid withdrawal in Planaria blocked by D-, but not L-, glucose. Brain Research. 1018: 181-5. PMID 15276876 DOI: 10.1016/J.Brainres.2004.05.057  0.771
2004 Raffa RB, Stagliano GW, Spencer SD. Protonation effect on drug affinity. European Journal of Pharmacology. 483: 323-4. PMID 14729124 DOI: 10.1016/J.Ejphar.2003.10.019  0.736
2003 Raffa RB, Stagliano GW, Umeda S. kappa-Opioid withdrawal in Planaria. Neuroscience Letters. 349: 139-42. PMID 12951188 DOI: 10.1016/S0304-3940(03)00814-0  0.782
2002 Raffa RB, Spencer SD, Schulingkamp RJ. Toward RNase inhibitors: thermodynamics of 2'-CMP/RNase-A binding in multi-ion buffer. Biochemical Pharmacology. 63: 1937-9. PMID 12093469 DOI: 10.1016/S0006-2952(02)00977-2  0.731
2002 Citver AS, Shields AM, Ciaccia LM, Schulingkamp RJ, Raffa RB. Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: III. Retinoids. Journal of Clinical Pharmacy and Therapeutics. 27: 161-8. PMID 12081629 DOI: 10.1046/J.1365-2710.2002.00410.X  0.759
2002 Spencer SD, Abdul O, Schulingkamp RJ, Raffa RB. Toward the design of ribonuclease (RNase) inhibitors: ion effects on the thermodynamics of binding of 2'-CMP to RNase A. The Journal of Pharmacology and Experimental Therapeutics. 301: 925-9. PMID 12023520 DOI: 10.1124/Jpet.301.3.925  0.73
2001 Raffa RB, Holland LJ, Schulingkamp RJ. Quantitative assessment of dopamine D2 antagonist activity using invertebrate (Planaria) locomotion as a functional endpoint. Journal of Pharmacological and Toxicological Methods. 45: 223-6. PMID 11755386 DOI: 10.1016/S1056-8719(01)00152-6  0.777
2000 Schulingkamp RJ, Pagano TC, Hung D, Raffa RB. Insulin receptors and insulin action in the brain: review and clinical implications. Neuroscience and Biobehavioral Reviews. 24: 855-72. PMID 11118610 DOI: 10.1016/S0149-7634(00)00040-3  0.729
2000 Raffa RB, Valdez JM, Holland LJ, Schulingkamp RJ. Energy-dependent UV light-induced disruption of (-)sulpiride antagonism of dopamine. European Journal of Pharmacology. 406: R11-2. PMID 11040357 DOI: 10.1016/S0014-2999(00)00730-5  0.76
1994 Raffa RB, Codd EE. Lack of glibenclamide or TEA affinity for opioid receptors: further evidence for in vivo modulation of antinociception at K+ channels. Brain Research. 650: 146-8. PMID 7953665 DOI: 10.1016/0006-8993(94)90217-8  0.304
Low-probability matches (unlikely to be authored by this person)
2006 Raffa R. Pharmacological aspects of successful long-term analgesia. Clinical Rheumatology. S9-15. PMID 16741785 DOI: 10.1007/S10067-006-0201-X  0.298
2014 Raffa R, Pergolizzi J, Taylor R, Kinzler E. (465) Trends and characteristics of individuals who abuse ER morphine: data from the RADARS System The Journal of Pain. 15: S92. DOI: 10.1016/J.Jpain.2014.01.376  0.296
2014 Pergolizzi J, Taylor R, Raffa R, Kinzler E. (448) Practitioners knowledge, attitudes, and practices regarding opioid abuse deterrent formulations The Journal of Pain. 15: S88. DOI: 10.1016/J.Jpain.2014.01.359  0.294
2013 Raffa RB, Baron S, Bhandal JS, Brown T, Song K, Tallarida CS, Rawls SM. Opioid receptor types involved in the development of nicotine physical dependence in an invertebrate (Planaria) model. Pharmacology, Biochemistry, and Behavior. 112: 9-14. PMID 24084318 DOI: 10.1016/J.Pbb.2013.09.012  0.28
1996 Raffa RB. A novel approach to the pharmacology of analgesics. The American Journal of Medicine. 101: 40S-46S. PMID 8764759 DOI: 10.1016/S0002-9343(96)00137-4  0.279
2012 Raffa RB, Buschmann H, Christoph T, Eichenbaum G, Englberger W, Flores CM, Hertrampf T, Kögel B, Schiene K, Straßburger W, Terlinden R, Tzschentke TM. Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opinion On Pharmacotherapy. 13: 1437-49. PMID 22698264 DOI: 10.1517/14656566.2012.696097  0.278
2011 Taylor R, Raffa RB, Pergolizzi JV. Naltrexone extended-release injection: an option for the management of opioid abuse. Substance Abuse and Rehabilitation. 2: 219-26. PMID 24474859 DOI: 10.2147/SAR.S17920  0.271
2016 Albert-Vartanian A, Boyd MR, Hall AL, Morgado SJ, Nguyen E, Nguyen VP, Patel SP, Russo LJ, Shao AJ, Raffa RB. Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? Journal of Clinical Pharmacy and Therapeutics. PMID 27245498 DOI: 10.1111/jcpt.12404  0.271
2006 Raffa RB, Baron DA, Tallarida RJ. Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria. European Journal of Pharmacology. 540: 200-1. PMID 16737694 DOI: 10.1016/j.ejphar.2006.04.027  0.27
2006 Rawls SM, Rodriguez T, Baron DA, Raffa RB. A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in Planaria. Brain Research. 1099: 82-7. PMID 16782070 DOI: 10.1016/J.Brainres.2006.04.103  0.268
2019 Raffa RB, Taylor R, Pergolizzi JV. Treating opioid-induced constipation in patients taking other medications: Avoiding CYP450 drug interactions. Journal of Clinical Pharmacy and Therapeutics. PMID 30793348 DOI: 10.1111/jcpt.12812  0.267
2008 Rawls SM, Cavallo F, Capasso A, Ding Z, Raffa RB. The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians. European Journal of Pharmacology. 584: 278-84. PMID 18342307 DOI: 10.1016/J.Ejphar.2008.02.018  0.267
1998 Raffa RB, Stone DJ. Mu receptor and Gi2alpha antisense attenuate [D-Met2]-FMRFamide antinociception in mice. Peptides. 19: 1171-5. PMID 9786166 DOI: 10.1016/S0196-9781(98)00065-5  0.266
1986 Zhu XZ, Raffa RB. Low affinity inhibition of opioid receptor binding by FMRFamide. Neuropeptides. 8: 55-61. PMID 3020469 DOI: 10.1016/0143-4179(86)90065-X  0.265
2009 Varga LI, Ako-Agugua N, Colasante J, Hertweck L, Houser T, Smith J, Watty AA, Nagar S, Raffa RB. Critical review of ropinirole and pramipexole - putative dopamine D(3)-receptor selective agonists - for the treatment of RLS. Journal of Clinical Pharmacy and Therapeutics. 34: 493-505. PMID 19744006 DOI: 10.1111/j.1365-2710.2009.01025.x  0.264
1999 Dixon DA, Fenix LA, Kim DM, Raffa RB. Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: I. Adenosine agonists. The Annals of Pharmacotherapy. 33: 480-8. PMID 10332540 DOI: 10.1345/aph.18215  0.262
2002 Raffa RB, Valdez JM. Cocaine withdrawal in Planaria. European Journal of Pharmacology. 430: 143-5. PMID 11698074 DOI: 10.1016/S0014-2999(01)01358-9  0.262
1992 Tallarida RJ, Raffa RB. Receptor regulation, competitive antagonism and pA2. Life Sciences. 51: PL61-5. PMID 1640794 DOI: 10.1016/0024-3205(92)90033-L  0.261
1994 Wild KD, Porreca F, Yamamura HI, Raffa RB. Differentiation of receptor subtypes by thermodynamic analysis: application to opioid delta receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 12018-21. PMID 7991576 DOI: 10.1073/pnas.91.25.12018  0.261
1995 Raffa RB, Martinez RP, Renzi MJ, Codd EE. LiCl uncouples signal transduction in morphine-induced supraspinal antinociception in mice. General Pharmacology. 26: 317-20. PMID 7590080 DOI: 10.1016/0306-3623(94)00207-4  0.261
1988 Heyman JS, Vaught JL, Raffa RB, Porreca F. Can supraspinal delta-opioid receptors mediate antinociception? Trends in Pharmacological Sciences. 9: 134-8. PMID 2854316 DOI: 10.1016/0165-6147(88)90195-2  0.26
1987 Mathiasen JR, Raffa RB, Vaught JL. C57BL/6J-bgJ (beige) mice: differential sensitivity in the tail flick test to centrally administered mu- and delta-opioid receptor agonists. Life Sciences. 40: 1989-94. PMID 3033418 DOI: 10.1016/0024-3205(87)90288-8  0.26
1989 Raffa RB. The action of FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides on mammals. Peptides. 9: 915-22. PMID 3067224 DOI: 10.1016/0196-9781(88)90141-6  0.259
2012 Pergolizzi JV, Raffa RB, Pergolizzi JS, Taylor R. Non-analgesic effects of opioids: factors relevant to opioid abuse and abuse- deterrent formulations. Current Pharmaceutical Design. 18: 6109-15. PMID 22747546  0.259
1982 Raffa RB, Porreca F, Cowan A, Tallarida RJ. Morphine-receptor dissociation constant and the stimulus-effect relation for inhibition of gastrointestinal transit in the rat. European Journal of Pharmacology. 79: 11-6. PMID 6282596 DOI: 10.1016/0014-2999(82)90569-6  0.256
2014 Raffa RB, Haidery M, Huang HM, Kalladeen K, Lockstein DE, Ono H, Shope MJ, Sowunmi OA, Tran JK, Pergolizzi JV. The clinical analgesic efficacy of buprenorphine. Journal of Clinical Pharmacy and Therapeutics. 39: 577-83. PMID 25070601 DOI: 10.1111/jcpt.12196  0.256
1999 Raffa RB. (Extra)thermodynamics of the drug-receptor interaction. Life Sciences. 65: 967-80. PMID 10499865 DOI: 10.1016/S0024-3205(99)00197-6  0.254
2012 Raffa RB, Ward SJ. CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant). Journal of Clinical Pharmacy and Therapeutics. 37: 260-5. PMID 21740450 DOI: 10.1111/j.1365-2710.2011.01284.x  0.254
2012 Raffa RB, Pergolizzi JV, Muñiz E, Taylor R, Pergolizzi J. Designing opioids that deter abuse. Pain Research and Treatment. 2012: 282981. PMID 23213510 DOI: 10.1155/2012/282981  0.254
2021 Pergolizzi JV, Dahan A, LeQuang JA, Raffa RB. The conundrum of polysubstance overdose. Journal of Clinical Pharmacy and Therapeutics. PMID 33460173 DOI: 10.1111/jcpt.13362  0.252
2012 Owaisat S, Raffa RB, Rawls SM. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neuroscience Letters. 525: 12-6. PMID 22877698 DOI: 10.1016/J.Neulet.2012.07.052  0.251
1987 Raffa RB, Mathiasen JR, Jacoby HI. Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of mu- and delta-opioid agonists. Life Sciences. 41: 2229-34. PMID 2823042 DOI: 10.1016/0024-3205(87)90520-0  0.251
2013 Zhang C, Tallarida CS, Raffa RB, Rawls SM. Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians. Physiology & Behavior. 112: 8-13. PMID 23415661 DOI: 10.1016/J.Physbeh.2013.02.002  0.251
2013 Lamarre NS, Raffa RB, Tallarida RJ. Cocaine synergism with α agonists in rat aorta: computational analysis reveals an action beyond reuptake inhibition. Drug and Alcohol Dependence. 129: 226-31. PMID 23270987 DOI: 10.1016/j.drugalcdep.2012.11.020  0.25
1994 Raffa RB, Schupsky JJ. Opioid mu receptor subtypes (possibly mu 1 and mu 2) revealed by morphine-induced antinociception vs endothelin-1 in recombinant inbred CXBK mice. Life Sciences. 54: PL57-62. PMID 8289581 DOI: 10.1016/0024-3205(94)00822-1  0.25
2018 Pergolizzi JV, LeQuang JA, Taylor R, Ossipov MH, Colucci D, Raffa RB. Designing safer analgesics: a focus on μ-opioid receptor pathways. Expert Opinion On Drug Discovery. 1-8. PMID 30175624 DOI: 10.1080/17460441.2018.1511539  0.249
1989 Raffa RB, Porreca F. Thermodynamic analysis of the drug-receptor interaction Life Sciences. 44: 245-258. PMID 2536880 DOI: 10.1016/0024-3205(89)90182-3  0.249
1998 Li JG, Raffa RB, Cheung P, Tzeng TB, Liu-Chen LY. Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor. European Journal of Pharmacology. 354: 227-37. PMID 9754924 DOI: 10.1016/S0014-2999(98)00444-0  0.247
2012 Pagán OR, Baker D, Deats S, Montgomery E, Tenaglia M, Randolph C, Kotturu D, Tallarida C, Bach D, Wilk G, Rawls S, Raffa RB. Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina. The International Journal of Developmental Biology. 56: 193-6. PMID 22451007 DOI: 10.1387/Ijdb.113486Op  0.246
1995 Raffa RB, Martinez RP. The 'glibenclamide-shift' of centrally-acting antinociceptive agents in mice Brain Research. 677: 277-282. PMID 7552253 DOI: 10.1016/0006-8993(95)00164-L  0.245
2010 Rawls SM, Patil T, Yuvasheva E, Raffa RB. First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians. Behavioural Pharmacology. 21: 301-13. PMID 20512030 DOI: 10.1097/Fbp.0B013E32833B0098  0.245
2013 Taylor R, Pergolizzi JV, Porreca F, Raffa RB. Opioid antagonists for pain. Expert Opinion On Investigational Drugs. 22: 517-25. PMID 23484859 DOI: 10.1517/13543784.2013.778973  0.245
2021 Peppin JF, Pergolizzi JV, Dahan A, Raffa RB. Are opioid receptor antagonists adequate for "Opioid" overdose in a changing reality? Journal of Clinical Pharmacy and Therapeutics. PMID 33913179 DOI: 10.1111/jcpt.13320  0.245
2000 Zebraski SE, Kochenash SM, Raffa RB. Lung opioid receptors: pharmacology and possible target for nebulized morphine in dyspnea. Life Sciences. 66: 2221-31. PMID 10855942 DOI: 10.1016/S0024-3205(00)00434-3  0.244
2010 Pergolizzi JV, Pappagallo M, Raffa RB, Gharibo C, Phillips RB, Desjonquères S, Tabor A. Preliminary observations of a novel topical oil with analgesic properties for treatment of acute and chronic pain syndromes. Pain Practice : the Official Journal of World Institute of Pain. 10: 201-13. PMID 20230451 DOI: 10.1016/J.Eujps.2011.08.031  0.244
2015 Peppin JF, Raffa RB. Delta opioid agonists: a concise update on potential therapeutic applications. Journal of Clinical Pharmacy and Therapeutics. 40: 155-66. PMID 25726896 DOI: 10.1111/jcpt.12244  0.243
2015 Vouga A, Gregg RA, Haidery M, Ramnath A, Al-Hassani HK, Tallarida CS, Grizzanti D, Raffa RB, Smith GR, Reitz AB, Rawls SM. Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates. Neuropharmacology. 91: 109-16. PMID 25496724 DOI: 10.1016/J.Neuropharm.2014.11.010  0.243
2016 Raffa RB, Burdge G, Gambrah J, Kinecki HE, Lin F, Lu B, Nguyen JT, Phan V, Ruan A, Sesay MA, Watkins TN. Cebranopadol: novel dual opioid/NOP receptor agonist analgesic. Journal of Clinical Pharmacy and Therapeutics. PMID 27778406 DOI: 10.1111/jcpt.12461  0.242
2008 Rawls SM, Baron S, Ding Z, Roth C, Zaveri N, Raffa RB. Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians. Neuropeptides. 42: 229-37. PMID 18479746 DOI: 10.1016/J.Npep.2008.03.005  0.242
1992 Raffa RB, Connelly CD. Supraspinal antinociception produced by [D-Met2]-FMRFamide in mice Neuropeptides. 22: 195-203. PMID 1331846 DOI: 10.1016/0143-4179(92)90162-P  0.242
1982 Porreca F, Raffa RB, Cowan A, Tallarida RJ. A comparison of the receptor constants of morphine and ethylketocyclazocine for analgesia and inhibition of gastrointestinal transit in the rat Life Sciences. 31: 1955-1961. PMID 6294424 DOI: 10.1016/0024-3205(82)90034-0  0.242
1993 Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic parameters for [D-Pen2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens European Journal of Pharmacology: Molecular Pharmacology. 244: 231-238. PMID 8384567 DOI: 10.1016/0922-4106(93)90148-3  0.24
2007 Rawls SM, Gomez T, Raffa RB. An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2). Pharmacology, Biochemistry, and Behavior. 86: 499-504. PMID 17306870 DOI: 10.1016/J.Pbb.2007.01.010  0.239
1996 Lai J, Ma SW, Porreca F, Raffa RB. Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. European Journal of Pharmacology. 316: 369-72. PMID 8982709 DOI: 10.1016/S0014-2999(96)00770-4  0.238
2008 Sacavage S, Patel H, Zielinski M, Acker J, Phillips AG, Raffa RB, Rawls SM. Withdrawal-like behavior in planarians is dependent on drug exposure duration. Neuroscience Letters. 439: 84-8. PMID 18511196 DOI: 10.1016/J.Neulet.2008.04.086  0.237
2005 Raffa RB, Martley AF. Amphetamine-induced increase in planarian locomotor activity and block by UV light. Brain Research. 1031: 138-40. PMID 15621023 DOI: 10.1016/j.brainres.2004.10.051  0.236
1989 Raffa RB. Supraspinal FMRFamide antagonizes morphine-induced horizontal, but not vertical, locomotor activity. Peptides. 10: 403-6. PMID 2755878 DOI: 10.1016/0196-9781(89)90050-8  0.236
2017 Silverman S, Raffa RB, Cataldo MJ, Kwarcinski M, Ripa SR. Use of immediate-release opioids as supplemental analgesia during management of moderate-to-severe chronic pain with buprenorphine transdermal system. Journal of Pain Research. 10: 1255-1263. PMID 28579823 DOI: 10.2147/JPR.S132595  0.236
2021 Peppin JF, Pergolizzi JV, Fudin J, Meyer TA, Raffa RB. History of Respiratory Stimulants. Journal of Pain Research. 14: 1043-1049. PMID 33889020 DOI: 10.2147/JPR.S298607  0.235
2008 Nagar S, Raffa RB. Looking beyond the administered drug: metabolites of opioid analgesics. The Journal of Family Practice. 57: S25-32. PMID 18655760  0.235
2008 Kadiev E, Patel V, Rad P, Thankachan L, Tram A, Weinlein M, Woodfin K, Raffa RB, Nagar S. Role of pharmacogenetics in variable response to drugs: focus on opioids. Expert Opinion On Drug Metabolism & Toxicology. 4: 77-91. PMID 18370860 DOI: 10.1517/17425255.4.1.77  0.235
1985 Raffa RB, Tallarida RJ. The concept of a changing receptor concentration: implications for the theory of drug action. Journal of Theoretical Biology. 115: 625-32. PMID 3930884 DOI: 10.1016/S0022-5193(85)80145-4  0.235
2017 Pergolizzi JV, Taylor R, LeQuang JA, Zampogna G, Raffa RB. Concise review of the management of iatrogenic emesis using cannabinoids: emphasis on nabilone for chemotherapy-induced nausea and vomiting. Cancer Chemotherapy and Pharmacology. PMID 28235999 DOI: 10.1007/s00280-017-3257-1  0.235
2014 Smith HS, Raffa RB, Pergolizzi JV, Taylor R, Tallarida RJ. Combining opioid and adrenergic mechanisms for chronic pain. Postgraduate Medicine. 126: 98-114. PMID 25141248 DOI: 10.3810/pgm.2014.07.2788  0.234
1987 Vaught JL, Mathiasen JR, Raffa RB. Utilization of μ opioid receptor deficient mice prove δ opioid receptor mediated analgesia: Differentiation between spinal and supraspinal receptor mechanisms Pain. 30: S248. DOI: 10.1016/0304-3959(87)91556-9  0.233
2014 Taylor R, Pergolizzi J, Raffa R, Kinzler E. (450) Abuse rates of oxycodone in the US: data from the RADARS System The Journal of Pain. 15: S88. DOI: 10.1016/J.Jpain.2014.01.361  0.233
2010 Raffa RB, Pergolizzi JV. Opioid formulations designed to resist/deter abuse. Drugs. 70: 1657-75. PMID 20731474 DOI: 10.2165/11537940-000000000-00000  0.232
1994 Raffa RB, Martinez RP, Connelly CD. G-protein antisense oligodeoxyribonucleotides and μ-opioid supraspinal antinociception European Journal of Pharmacology. 258. PMID 7925586 DOI: 10.1016/0014-2999(94)90073-6  0.232
2010 Tallarida RJ, Raffa RB. The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations. Pharmacology & Therapeutics. 127: 165-74. PMID 20546783 DOI: 10.1016/j.pharmthera.2010.04.011  0.231
1994 Raffa RB, Kim A, Rice KC, de Costa BR, Codd EE, Rothman RB. Low affinity of FMRFamide and four FaRPs (FMRFamide-related peptides), including the mammalian-derived FaRPs F-8-Famide (NPFF) and A-18-Famide, for opioid mu, delta, kappa 1, kappa 2a, or kappa 2b receptors. Peptides. 15: 401-4. PMID 7937312 DOI: 10.1016/0196-9781(94)90195-3  0.23
2014 Raffa RB, Taylor R, Pergolizzi JV. Sequestered naltrexone in sustained release morphine or oxycodone - a way to inhibit illicit use? Expert Opinion On Drug Safety. 13: 181-90. PMID 24206269 DOI: 10.1517/14740338.2013.841136  0.23
1988 Raffa RB, Mathiasen JR, Brown DQ. Mu-, but not delta-, opioid receptor-mediated antinociception in mice is attenuated by gamma-irradiation. Brain Research. 447: 393-7. PMID 2839268 DOI: 10.1016/0006-8993(88)91147-X  0.23
1994 Connelly CD, Martinez RP, Schupsky JJ, Porreca F, Raffa RB. Etonitazene-induced antinociception in μ1 opioid receptor deficient CXBK mice: Evidence for a role for μ2 receptors in supraspinal antinociception Life Sciences. 54. PMID 7910928 DOI: 10.1016/0024-3205(94)90037-X  0.229
2011 Raffa RB, Raffa KF. Potential insight for drug discovery from high fidelity receptor-mediated transduction mechanisms in insects. Expert Opinion On Drug Discovery. 6: 1091-1101. PMID 21984882 DOI: 10.1517/17460441.2011.611497  0.229
2011 Pergolizzi JV, Raffa R, Taylor R. Prophylaxis of postoperative nausea and vomiting in adolescent patients: a review with emphasis on combination of fixed-dose ondansetron and transdermal scopolamine. Journal of Drug Delivery. 2011: 426813. PMID 21773046 DOI: 10.1155/2011/426813  0.228
1992 Raffa RB, Connelly CD, Martinez RP. Opioid efficacy is linked to the LiCl-sensitive, inositol-1,4,5-trisphosphate-restorable pathway European Journal of Pharmacology. 217: 221-223. PMID 1330592 DOI: 10.1016/0014-2999(92)90879-9  0.228
2018 Pergolizzi JV, LeQuang JA, Taylor R, Raffa RB. Going beyond prescription pain relievers to understand the opioid epidemic: the role of illicit fentanyl, new psychoactive substances, and street heroin. Postgraduate Medicine. 130: 1-8. PMID 29190175 DOI: 10.1080/00325481.2018.1407618  0.228
2007 Xie S, Furjanic MA, Ferrara JJ, McAndrew NR, Ardino EL, Ngondara A, Bernstein Y, Thomas KJ, Kim E, Walker JM, Nagar S, Ward SJ, Raffa RB. The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use. Journal of Clinical Pharmacy and Therapeutics. 32: 209-31. PMID 17489873 DOI: 10.1111/j.1365-2710.2007.00817.x  0.228
2017 Pergolizzi JV, Raffa RB, Pappagallo M, Fleischer C, Pergolizzi J, Zampogna G, Duval E, Hishmeh J, LeQuang JA, Taylor R. Peripherally acting μ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy. Patient Preference and Adherence. 11: 107-119. PMID 28176913 DOI: 10.2147/PPA.S78042  0.227
2002 Raffa RB. Harmonic mean relationship between affinity for wild-type receptors and alanine-scan mutants. Journal of Theoretical Biology. 218: 207-14. PMID 12381293 DOI: 10.1006/jtbi.2002.3069  0.227
2005 Raffa RB, Desai P. Description and quantification of cocaine withdrawal signs in Planaria. Brain Research. 1032: 200-2. PMID 15680960 DOI: 10.1016/j.brainres.2004.10.052  0.226
2012 Tallarida RJ, Lamarre N, Raffa RB. 'Null method' determination of drug biophase concentration. Pharmaceutical Research. 29: 637-42. PMID 22037914 DOI: 10.1007/s11095-011-0612-5  0.225
2019 Pergolizzi JV, Raffa RB. Safety And Efficacy Of The Unique Opioid Buprenorphine For The Treatment Of Chronic Pain. Journal of Pain Research. 12: 3299-3317. PMID 31997882 DOI: 10.2147/JPR.S231948  0.225
2004 Raffa RB, Walker EA, Sterious SN. Opioid receptors and acetaminophen (paracetamol). European Journal of Pharmacology. 503: 209-10. PMID 15496316 DOI: 10.1016/j.ejphar.2004.08.055  0.224
2014 Miller K, Yarlas A, Wen W, Dain B, Lynch SY, Ripa SR, Pergolizzi JV, Raffa R. The impact of buprenorphine transdermal delivery system on activities of daily living among patients with chronic low back pain: an application of the international classification of functioning, disability and health. The Clinical Journal of Pain. 30: 1015-22. PMID 24394747 DOI: 10.1097/Ajp.0000000000000068  0.223
1986 Raffa RB, Bianchi CP. Antagonism of receptor-activated biological effects mediated by second messenger pathways. Life Sciences. 38: 251-7. PMID 3001466 DOI: 10.1016/0024-3205(86)90310-3  0.223
1997 Goode TL, Raffa RB. An examination of the relationship between mu-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins. Life Sciences. 60: PL107-13. PMID 9042382 DOI: 10.1016/S0024-3205(96)00684-4  0.223
1988 Raffa RB, Baldy WJ, Shank RP, Mathiasen JR, Vaught JL. [3H][D-Ala2,NMePhe4,Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice. Peptides. 9: 637-42. PMID 2843835 DOI: 10.1016/0196-9781(88)90176-3  0.222
2020 Pergolizzi JV, Raffa RB, Rosenblatt MH. Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management. Journal of Clinical Pharmacy and Therapeutics. PMID 31986228 DOI: 10.1111/jcpt.13114  0.222
2015 Pham TC, Fudin J, Raffa RB. Is levorphanol a better option than methadone? Pain Medicine (Malden, Mass.). 16: 1673-9. PMID 26307179 DOI: 10.1111/pme.12795  0.221
1992 Raffa RB, Martinez RP, Porreca F. Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the μ-opioid receptor deficient CXBX mouse European Journal of Pharmacology. 216: 453-456. PMID 1330585 DOI: 10.1016/0014-2999(92)90446-B  0.221
2019 Pergolizzi JJ, LeQuang J, Taylor JR, Ossipov M, Raffa R. Kappa-opioid receptor agonists in pain treatment Drugs of the Future. 44: 39. DOI: 10.1358/dof.2019.44.1.2885875  0.221
2000 Carfagno ML, Hoskins LA, Pinto ME, Yeh JC, Raffa RB. Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: II. Glutamate (Ant)agonists. The Annals of Pharmacotherapy. 34: 788-97. PMID 10860140 DOI: 10.1345/aph.19146  0.22
2010 Pergolizzi J, Aloisi AM, Dahan A, Filitz J, Langford R, Likar R, Mercadante S, Morlion B, Raffa RB, Sabatowski R, Sacerdote P, Torres LM, Weinbroum AA. Current knowledge of buprenorphine and its unique pharmacological profile. Pain Practice : the Official Journal of World Institute of Pain. 10: 428-50. PMID 20492579 DOI: 10.1111/j.1533-2500.2010.00378.x  0.22
1989 Raffa RB, Vaught JL, Porreca F. Can equal pA2 values be compatible with receptor differences? Trends in Pharmacological Sciences. 10: 183-185. PMID 2667226 DOI: 10.1016/0165-6147(89)90234-4  0.22
2018 Pergolizzi JV, Taylor R, LeQuang JA, Raffa RB. What's Holding Back Abuse-Deterrent Opioid Formulations? Considering 12 U.S. Stakeholders. Expert Opinion On Drug Delivery. PMID 29739241 DOI: 10.1080/17425247.2018.1473374  0.219
1982 Porreca F, Cowan A, Raffa RB, Tallarida RJ. Estimation in vivo of the receptor constants of morphine in naive and morphine-tolerant rats Life Sciences. 31: 2355-2358. PMID 6298527 DOI: 10.1016/0024-3205(82)90155-2  0.219
1993 Raffa RB, Mathiasen JR, Kimball ES, Vaught JL. The combined immunological and antinociceptive defects of beige-J mice: the possible existence of a 'mu-repressin'. Life Sciences. 52: 1-8. PMID 8380213 DOI: 10.1016/0024-3205(93)90281-7  0.219
2008 Farrell MS, Gilmore K, Raffa RB, Walker EA. Behavioral characterization of serotonergic activation in the flatworm Planaria. Behavioural Pharmacology. 19: 177-82. PMID 18469535 DOI: 10.1097/FBP.0b013e3282fe885e  0.217
2007 Raffa RB, Ding Z. Examination of the preclinical antinociceptive efficacy of buprenorphine and its designation as full- or partial-agonist Acute Pain. 9: 145-152. DOI: 10.1016/J.Acpain.2007.07.002  0.217
1996 Raffa RB, Stone DJ. Could dual G-protein coupling explain [D-Met2]FMRFamide's mixed action in vivo? Peptides. 17: 1261-5. PMID 8971917 DOI: 10.1016/S0196-9781(96)00196-9  0.216
2015 Yarlas A, Miller K, Wen W, Lynch SY, Munera C, Pergolizzi JV, Raffa R, Ripa SR. Buprenorphine transdermal system compared with placebo reduces interference in functioning for chronic low back pain. Postgraduate Medicine. 127: 38-45. PMID 25526229 DOI: 10.1080/00325481.2014.992715  0.215
2013 Raffa RB, Pergolizzi JV. Opioid-induced hyperalgesia: is it clinically relevant for the treatment of pain patients? Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses. 14: e67-83. PMID 23972873 DOI: 10.1016/j.pmn.2011.04.002  0.215
2009 Ding Z, Raffa RB. Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. British Journal of Pharmacology. 157: 831-43. PMID 19422392 DOI: 10.1111/J.1476-5381.2009.00209.X  0.215
1985 Raffa RB, Robinson MJ, Tallarida RJ. Ultraviolet light-induced photorelaxation of agonist-contracted rabbit aorta: Further characterization and the estimation of drug-receptor rate constants Drug Development Research. 5: 359-369. DOI: 10.1002/ddr.430050409  0.215
2008 Pergolizzi J, Böger RH, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa RB, Sacerdote P. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Practice : the Official Journal of World Institute of Pain. 8: 287-313. PMID 18503626 DOI: 10.1111/J.1533-2500.2008.00204.X  0.213
2015 Yarlas A, Miller K, Wen W, Lynch SY, Munera C, Dain B, Pergolizzi JV, Raffa R, Ripa SR. A Subgroup Analysis Found no Diminished Response to Buprenorphine Transdermal System Treatment for Chronic Low Back Pain Patients Classified with Depression. Pain Practice : the Official Journal of World Institute of Pain. PMID 25865734 DOI: 10.1111/Papr.12298  0.213
2000 Betz C, Mihalic D, Pinto ME, Raffa RB. Could a common biochemical mechanism underlie addictions? Journal of Clinical Pharmacy and Therapeutics. 25: 11-20. PMID 10771460 DOI: 10.1046/j.1365-2710.2000.00260.x  0.211
2013 Raffa RB, Shah S, Tallarida CS, Rawls SM. Amphetamine Conditioned Place Preference in Planarians Journal of Behavioral and Brain Science. 3: 131-136. DOI: 10.4236/Jbbs.2013.31012  0.21
1998 Raffa RB. Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. Life Sciences. 62: PL265-70. PMID 9585174 DOI: 10.1016/S0024-3205(98)00085-X  0.209
2018 Raffa RB, Elling C, Tzschentke TM. Does 'Strong Analgesic' Equal 'Strong Opioid'? Tapentadol and the Concept of 'µ-Load'. Advances in Therapy. PMID 30206823 DOI: 10.1007/s12325-018-0778-x  0.208
2017 Pergolizzi JV, Raffa RB, Taylor R, Vacalis S. Abuse-deterrent opioids: an update on current approaches and considerations. Current Medical Research and Opinion. 1-42. PMID 29262730 DOI: 10.1080/03007995.2017.1419171  0.208
1983 Porreca F, Cowan A, Raffa RB, Tallarida RJ. Ketazocines and morphine: Effects on gastrointestinal transit after central and peripheral administration Life Sciences. 32: 1785-1790. PMID 6339861 DOI: 10.1016/0024-3205(83)90843-3  0.207
2020 Pergolizzi JV, Magnusson P, Raffa RB, LeQuang JA, Coluzzi F. Developments in Combined Analgesic Regimens for Improved Safety in Postoperative Pain Management. Expert Review of Neurotherapeutics. PMID 32749896 DOI: 10.1080/14737175.2020.1806058  0.206
2021 Pergolizzi JV, Webster LR, Vortsman E, Ann LeQuang J, Raffa RB. Wooden Chest syndrome: The atypical pharmacology of fentanyl overdose. Journal of Clinical Pharmacy and Therapeutics. PMID 34240442 DOI: 10.1111/jcpt.13484  0.205
2018 Raffa RB, Pergolizzi JV, Taylor R, Ossipov MH. Nature's first "atypical opioids": Kratom and mitragynines. Journal of Clinical Pharmacy and Therapeutics. PMID 29520812 DOI: 10.1111/jcpt.12676  0.204
1992 Raffa RB, Addo MF, Gill A. Supraspinal administration of [D-Met2]FMRFamide produces a naloxone-sensitive increase in heart rate in unrestrained spontaneously hypertensive rats. Neuropeptides. 21: 201-5. PMID 1355596 DOI: 10.1016/0143-4179(92)90023-P  0.204
2016 Raffa RB, Taylor R, Pergolizzi JV, Nalamachu S, Edwards ES, Edwards ET. Application of human factors engineering (HFE) to the design of a naloxone auto-injector for the treatment of opioid emergencies. Drug Delivery and Translational Research. PMID 27562292 DOI: 10.1007/s13346-016-0323-x  0.204
2018 Pergolizzi JV, Taylor R, LeQuang JA, Raffa RB. The role and mechanism of action of menthol in topical analgesic products. Journal of Clinical Pharmacy and Therapeutics. PMID 29524352 DOI: 10.1111/jcpt.12679  0.204
2010 Rawls SM, Shah H, Ayoub G, Raffa RB. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neuroscience Letters. 484: 113-7. PMID 20709144 DOI: 10.1016/J.Neulet.2010.08.027  0.203
2000 Xin L, Geller EB, Bastepe M, Raffa RB, Mao GF, Ashby B, Adler MW. Suppression of fever and hyperalgesic responses to the EP3-receptor agonist GR 63799X by EP3-receptor antisense in rats Journal of Thermal Biology. 25: 77-79. DOI: 10.1016/S0306-4565(99)00093-5  0.202
2012 Taylor R, Pergolizzi J, Raffa R. Tapentadol for the Treatment of Chronic Pain International Journal of Clinical Reviews. DOI: 10.5275/Ijcr.2012.10.01  0.202
2014 Cowan A, Raffa RB, Tallarida CS, Tallarida RJ, Christoph T, Schröder W, Tzschentke TM. Lack of synergistic interaction between the two mechanisms of action of tapentadol in gastrointestinal transit. European Journal of Pain (London, England). 18: 1148-56. PMID 24574066 DOI: 10.1002/J.1532-2149.2014.00461.X  0.202
2018 Pergolizzi JV, Taylor R, LeQuang JA, Raffa RB. Managing severe pain and abuse potential: the potential impact of a new abuse-deterrent formulation oxycodone/naltrexone extended-release product. Journal of Pain Research. 11: 301-311. PMID 29445297 DOI: 10.2147/JPR.S127602  0.2
2023 Pergolizzi J, Raffa R, LeQuang JAK, Breve F, Varrassi G. Old Drugs and New Challenges: A Narrative Review of Nitazenes. Cureus. 15: e40736. PMID 37485167 DOI: 10.7759/cureus.40736  0.2
1991 Vaught JL, Connelly CD, Martinez RP, Codd EE, Raffa RB. Evidence for an Unexpected Non-Opioid Component of Tramadol-Induced Antinociception In Vivo The Clinical Journal of Pain. 7: 55. DOI: 10.1097/00002508-199103000-00068  0.2
1987 Scott RW, Goode TL, Raffa RB. Pilocarpine-induced reciprocal hindlimb scratching in mice. Pharmacology, Biochemistry, and Behavior. 26: 327-31. PMID 2437594 DOI: 10.1016/0091-3057(87)90126-2  0.2
2020 Webster L, Gudin J, Raffa RB, Kuchera J, Rauck R, Fudin J, Adler J, Mallick-Searle T. Understanding Buprenorphine for Use in Chronic Pain: Expert Opinion. Pain Medicine (Malden, Mass.). PMID 31917418 DOI: 10.1093/pm/pnz356  0.199
2018 Raffa RB, Pergolizzi JV, Taylor R, Ossipov MH. Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs). Journal of Clinical Pharmacy and Therapeutics. PMID 29722031 DOI: 10.1111/jcpt.12687  0.199
2017 Raffa RB, Colucci R, Pergolizzi JV. The effects of food on opioid-induced nausea and vomiting and pharmacological parameters: a systematic review. Postgraduate Medicine. PMID 28635354 DOI: 10.1080/00325481.2017.1345282  0.198
2008 Raffa RB. Basic pharmacology relevant to drug abuse assessment: tramadol as example. Journal of Clinical Pharmacy and Therapeutics. 33: 101-8. PMID 18315774 DOI: 10.1111/j.1365-2710.2008.00897.x  0.198
2018 Pergolizzi JV, Taylor R, LeQuang JA, Bisney J, Raffa RB, Pergolizzi F, Colucci D, Batastini L. Driving under the influence of opioids: What prescribers should know. Journal of Opioid Management. 14: 415-427. PMID 30629278 DOI: 10.5055/jom.2018.0474  0.197
2018 Eke-Okoro UJ, Raffa RB, Pergolizzi JV, Breve F, Taylor R. Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia. Journal of Clinical Pharmacy and Therapeutics. PMID 29722036 DOI: 10.1111/jcpt.12703  0.197
1993 Mattia A, Vanderah T, Raffa RB, Vaught JL, Tallarida RJ, Porreca F. Characterization of the unusual antinociceptive profile of tramadol in mice Drug Development Research. 28: 176-182. DOI: 10.1002/ddr.430280208  0.195
2011 Ward SJ, Raffa RB. Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies. Obesity (Silver Spring, Md.). 19: 1325-34. PMID 21475141 DOI: 10.1038/oby.2011.69  0.195
1999 Lashbrook JM, Ossipov MH, Hunter JC, Raffa RB, Tallarida RJ, Porreca F. Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. Pain. 82: 65-72. PMID 10422661 DOI: 10.1016/S0304-3959(99)00031-7  0.193
2013 Raffa RB, Pergolizzi JV. A modern analgesics pain 'pyramid'. Journal of Clinical Pharmacy and Therapeutics. 39: 4-6. PMID 24383938 DOI: 10.1111/jcpt.12110  0.19
1991 Raffa RB, Orr N, Connelly CD, Hollingworth RM. XAMI and DCDM, agonists at cAMP-associated octopamine receptors in cockroach nerve cord, produce centrally mediated antinociception in mice Brain Research. 559: 211-219. PMID 1686573 DOI: 10.1016/0006-8993(91)90004-F  0.19
1992 Raffa RB, Shank RP, Vaught JL. Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity. Psychopharmacology. 108: 320-6. PMID 1387963 DOI: 10.1007/BF02245118  0.19
1995 Raffa RB, Martinez RP. Antinociceptive defect of beige-J mice reversed by i.c.v. IP<inf>3</inf> or myo-inositol Neuroreport. 6: 1434-1436. PMID 7488742 DOI: 10.1097/00001756-199507100-00018  0.189
1994 Press JB, Raffa RB. Patent Update Central & Peripheral Nervous System: Recent advances in opioid and non-opioid analgesia (1992–1993) Expert Opinion On Therapeutic Patents. 4: 379-393. DOI: 10.1517/13543776.4.4.379  0.189
2019 Raffa RB, Pergolizzi JV, Taylor R, James RP, Pirner M. Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine Pharmacology &Amp; Pharmacy. 10: 1-10. DOI: 10.4236/PP.2019.101001  0.188
2014 Raffa RB. On subclasses of opioid analgesics. Current Medical Research and Opinion. 30: 2579-84. PMID 25105308 DOI: 10.1185/03007995.2014.952717  0.188
1987 Jacoby MB, Jacoby HI, Mathiasen JR, Raffa RB. The effect of Phe-Met-Arg-Phe-NH2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice. Neuroscience Letters. 83: 128-32. PMID 3441291 DOI: 10.1016/0304-3940(87)90228-X  0.188
2012 Tallarida C, Song K, Raffa RB, Rawls SM. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids. 42: 2521-4. PMID 21850438 DOI: 10.1007/S00726-011-1052-6  0.186
2019 Raffa RB, Pergolizzi JV. <i>Commentary</i>: Benzodiazepine (BZD) and Related BZD-Receptor Agonists: Basic Science Reasons to Limit to Four Weeks or Less Pharmacology &Amp; Pharmacy. 10: 357-364. DOI: 10.4236/PP.2019.108029  0.186
2017 Pergolizzi JV, LeQuang JA, Berger GK, Raffa RB. The Basic Pharmacology of Opioids Informs the Opioid Discourse about Misuse and Abuse: A Review. Pain and Therapy. PMID 28341939 DOI: 10.1007/s40122-017-0068-3  0.185
1996 Raffa RB, Goode TL, Martinez RP, Jacoby HI. A Gi2alpha antisense oligonucleotide differentiates morphine antinociception, constipation and acute dependence in mice. Life Sciences. 58: PL 73-6. PMID 8594299 DOI: 10.1016/0024-3205(95)02300-3  0.185
2018 Pergolizzi JV, Ossipov MH, Taylor R, Raffa RB. “New-Look” Opioids: Biased Ligands Pharmacology &Amp; Pharmacy. 9: 242-249. DOI: 10.4236/pp.2018.97018  0.184
1999 Raffa RB, Stone DJ, Hipp SJ. Differential cholera-toxin sensitivity of supraspinal antinociception induced by the cannabinoid agonists delta9-THC, WIN 55,212-2 and anandamide in mice. Neuroscience Letters. 263: 29-32. PMID 10218903 DOI: 10.1016/S0304-3940(99)00096-8  0.184
1989 Raffa RB, Jacoby HI. A-18-famide and F-8-famide, endogenous mammalian equivalents of the molluscan neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2), inhibit colonic bead expulsion time in mice. Peptides. 10: 873-5. PMID 2587427 DOI: 10.1016/0196-9781(89)90127-7  0.184
2015 Pergolizzi JV, Zampogna G, Taylor R, Raffa RB. Long-term efficacy, safety and tolerability of Remoxy for the management of chronic pain. Expert Review of Neurotherapeutics. 15: 231-8. PMID 25683255 DOI: 10.1586/14737175.2015.1015418  0.183
1991 Vaught JL, Raffa RB. Centrally-mediated antinociceptive action of RWJ-22757 (formerly McN-5195): involvement of spinal descending inhibitory pathways (an hypothesis). Life Sciences. 48: 2233-41. PMID 2046456 DOI: 10.1016/0024-3205(91)90338-C  0.181
1992 Raffa RB, Martinez RP. Morphine antinociception is mediated through a LiCl-sensitive, IP3-restorable pathway European Journal of Pharmacology. 215: 357-358. PMID 1327809 DOI: 10.1016/0014-2999(92)90060-H  0.181
2010 Raffa RB, Pergolizzi JV, Segarnick DJ, Tallarida RJ. Oxycodone combinations for pain relief. Drugs of Today (Barcelona, Spain : 1998). 46: 379-98. PMID 20571607 DOI: 10.1358/dot.2010.46.6.1470106  0.18
2021 Hale M, Garofoli M, Raffa RB. Benefit-Risk Analysis of Buprenorphine for Pain Management. Journal of Pain Research. 14: 1359-1369. PMID 34079354 DOI: 10.2147/JPR.S305146  0.18
1991 Jacoby HI, Bonfilio AC, Raffa RB. Central and peripheral administration of serotonin produces opposite effects on mouse colonic propulsive motility. Neuroscience Letters. 122: 122-6. PMID 2057128 DOI: 10.1016/0304-3940(91)90208-B  0.179
2021 Pergolizzi JV, Dahan A, Ann LeQuang J, Raffa RB. Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit. Journal of Clinical Pharmacy and Therapeutics. PMID 34111307 DOI: 10.1111/jcpt.13462  0.179
2017 Pergolizzi JV, Breve F, Taylor R, Raffa RB, Strasburger SE, LeQuang JA. Considering tapentadol as a first-line analgesic: 14 questions. Pain Management. PMID 28434283 DOI: 10.2217/pmt-2016-0063  0.179
1995 Raffa RB, Connelly CD, Martinez RP, Schupsky JJ, Argentieri DC, Singer MM, Smith IL. Antinociceptive effects of a novel dual cyclooxygenase/5-lipoxygenase inhibitor (Tepoxalin) and its primary (carboxylic acid) metabolite (RWJ 20142) in acute tests in mice and rats Drug Development Research. 36: 81-90. DOI: 10.1002/ddr.430360203  0.178
2003 Tallarida RJ, Cowan A, Raffa RB. Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice. The Journal of Pharmacology and Experimental Therapeutics. 307: 699-704. PMID 12966152 DOI: 10.1124/jpet.103.054320  0.178
2012 Pergolizzi JV, Raffa RB, Tallarida R, Taylor R, Labhsetwar SA. Continuous multimechanistic postoperative analgesia: a rationale for transitioning from intravenous acetaminophen and opioids to oral formulations. Pain Practice : the Official Journal of World Institute of Pain. 12: 159-73. PMID 21676161 DOI: 10.1111/j.1533-2500.2011.00476.x  0.178
2005 Prabandham A, Raffa R, Tallarida R, Walker E. B111 EVALUATION OF MULTIPLICATIVE OPIOID ANTAGONIST INTERACTIONS IN THE RAT WARM-WATER TAIL-WITHDRAWAL ASSAY Behavioural Pharmacology. 16: S101. DOI: 10.1097/00008877-200509001-00316  0.178
1997 Tallarida RJ, Stone DJ, Raffa RB. Efficient designs for studying synergistic drug combinations. Life Sciences. 61: PL 417-25. PMID 9416783 DOI: 10.1016/S0024-3205(97)01030-8  0.178
2009 Pergolizzi JV, Raffa RB. Oxymorphone and Opioid Rotation Pain Medicine. 10: S39-S48. DOI: 10.1111/j.1526-4637.2009.00598.x  0.176
1991 Raffa RB, Schupsky JJ, Martinez RP, Jacoby HI. Endothelin-1-induced nociception. Life Sciences. 49: PL61-5. PMID 1875787 DOI: 10.1016/0024-3205(91)90252-7  0.176
2012 Raffa RB, Pergolizzi JV. Intracerebroventricular opioids for intractable pain. British Journal of Clinical Pharmacology. 74: 34-41. PMID 22295988 DOI: 10.1111/j.1365-2125.2012.04201.x  0.175
1982 Raffa RB, Porreca F, Cowan A, Tallarida RJ. Extraction and measurement of morphine: Correlation of brain level and s.c. dose in drug-naive and morphine-tolerant rats Life Sciences. 31: 2299-2302. PMID 7162345 DOI: 10.1016/0024-3205(82)90142-4  0.173
2012 Raffa RB, Burmeister JJ, Yuvasheva E, Pergolizzi JV. QTc interval prolongation by d-propoxyphene: what about other analgesics? Expert Opinion On Pharmacotherapy. 13: 1397-409. PMID 22568597 DOI: 10.1517/14656566.2012.682150  0.173
1989 Raffa RB, Ortegón ME, Robisch DM, Martin GE. In vivo demonstration of the enhancement of MK-801 by L-glutamate. Life Sciences. 44: 1593-9. PMID 2567482 DOI: 10.1016/0024-3205(89)90454-2  0.171
1999 Li QS, Connelly CD, Codd EE, Raffa RB. Method for comparison of the hemodynamic effects of equi-antinociceptive oral doses of drugs in anesthetized rats Journal of Pharmacological and Toxicological Methods. 42: 127-133. PMID 10964010 DOI: 10.1016/S1056-8719(00)00041-1  0.171
2000 Ross TM, Jetter MC, McDonnell ME, Boyd RE, Connelly CD, Martinez RP, Lewis MA, Codd EE, Raffa RB, Reitz AB. Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor. Journal of Medicinal Chemistry. 43: 1423-6. PMID 10753480 DOI: 10.1021/Jm000128R  0.171
2014 Taylor R, Raffa RB, Pergolizzi JV. Opioid formulations with sequestered naltrexone: a perspective review. Therapeutic Advances in Drug Safety. 5: 129-37. PMID 25083268 DOI: 10.1177/2042098614526769  0.17
1996 Raffa RB, Connelly CD, Chambers JR, Stone DJ. Alpha-subunit G-protein antisense oligodeoxynucleotide effects on supraspinal (i.c.v.) alpha2-adrenoceptor antinociception in mice. Life Sciences. 58: PL 77-80. PMID 8594300 DOI: 10.1016/0024-3205(95)02301-1  0.17
2010 Raffa RB. The M5 muscarinic receptor as possible target for treatment of drug abuse. Journal of Clinical Pharmacy and Therapeutics. 34: 623-9. PMID 20175795 DOI: 10.1111/j.1365-2710.2009.01059.x  0.168
1995 Stone DJ, Wild KD, Raffa RB. Time-Course of Gi2α Oligodeoxyribonucleotide Antisense Antagonism of μ-Opioid Antinociception in the Mouse Tail-Immersion Test Analgesia. 1: 770-773. DOI: 10.3727/107156995819564022  0.168
1987 Raffa RB, Mathiasen JR, Goode TL, Vaught JL. Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M1 type receptors. Life Sciences. 41: 1831-6. PMID 2443784 DOI: 10.1016/0024-3205(87)90702-8  0.167
2010 Raffa RB, Finno KE, Tallarida CS, Rawls SM. Topiramate-antagonism of L-glutamate-induced paroxysms in planarians. European Journal of Pharmacology. 649: 150-3. PMID 20863783 DOI: 10.1016/J.Ejphar.2010.09.021  0.167
2010 Raffa RB, Pergolizzi JV, Tallarida RJ. The determination and application of fixed-dose analgesic combinations for treating multimodal pain. The Journal of Pain : Official Journal of the American Pain Society. 11: 701-9. PMID 20338825 DOI: 10.1016/j.jpain.2009.12.010  0.165
2015 Pergolizzi JV, Taylor R, Raffa RB. The Potential Role of an Extended-Release, Abuse-Deterrent Oxycodone/Acetaminophen Fixed-Dose Combination Product for the Treatment of Acute Pain. Advances in Therapy. 32: 485-95. PMID 26026272 DOI: 10.1007/s12325-015-0213-5  0.163
1998 Raffa RB. THE POTENTIAL AND PITFALLS OF IN VIVO AFFINITY AND EFFICACY MEASURES AS APPLIED TO CENTRALLY-ACTING ANALGESICS Behavioural Pharmacology. 9: S76. DOI: 10.1097/00008877-199808000-00174  0.16
2017 Raffa RB, Pergolizzi JV, Taylor R. The rapid-onset antidepressant effect of ketamine: More surprises? Journal of Clinical Pharmacy and Therapeutics. 43: 308-311. PMID 29178131 DOI: 10.1111/jcpt.12656  0.158
2014 Nalamachu S, Pergolizzi JV, Raffa RB, Lakkireddy DR, Taylor R. Drug-drug interaction between NSAIDS and low-dose aspirin: a focus on cardiovascular and GI toxicity. Expert Opinion On Drug Safety. 13: 903-17. PMID 24905189 DOI: 10.1517/14740338.2014.924924  0.158
2006 Raffa RB, Tallarida RJ. Modified 'Joyce model' of opioid dependence/withdrawal. European Journal of Pharmacology. 551: 54-7. PMID 17045985 DOI: 10.1016/j.ejphar.2006.09.003  0.158
2013 Cangoz S, Chang YY, Chempakaseril SJ, Guduru RC, Huynh LM, John JS, John ST, Joseph ME, Judge R, Kimmey R, Kudratov K, Lee PJ, Madhani IC, Shim PJ, Singh S, ... ... Raffa RB, et al. The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors. Journal of Clinical Pharmacy and Therapeutics. 38: 350-9. PMID 23909868 DOI: 10.1111/jcpt.12077  0.156
2001 Raffa RB. Antihistamines as analgesics. Journal of Clinical Pharmacy and Therapeutics. 26: 81-5. PMID 11350529 DOI: 10.1046/j.1365-2710.2001.00330.x  0.156
2005 Raffa RB, Iannuzzo JR, Levine DR, Saeid KK, Schwartz RC, Sucic NT, Terleckyj OD, Young JM. Bacterial communication ("quorum sensing") via ligands and receptors: a novel pharmacologic target for the design of antibiotic drugs. The Journal of Pharmacology and Experimental Therapeutics. 312: 417-23. PMID 15528454 DOI: 10.1124/jpet.104.075150  0.155
1996 Tallarida RJ, Raffa RB. Testing for synergism over a range of fixed ratio drug combinations: replacing the isobologram. Life Sciences. 58: PL 23-8. PMID 8606615 DOI: 10.1016/0024-3205(95)02271-6  0.155
2016 Lin TC, Ger LP, Pergolizzi JV, Raffa RB, Wang JO, Ho ST. Long-term use of opioids in 210 officially registered patients with chronic noncancer pain in Taiwan: A cross-sectional study. Journal of the Formosan Medical Association = Taiwan Yi Zhi. PMID 28024664 DOI: 10.1016/j.jfma.2016.10.015  0.154
1994 Shank RP, Gardocki JF, Vaught JL, Davis CB, Schupsky JJ, Raffa RB, Dodgson SJ, Nortey SO, Maryanoff BE. Topiramate: Preclinical evaluation of a structurally novel anticonvulsant Epilepsia. 35: 450-460. PMID 8156972 DOI: 10.1111/j.1528-1157.1994.tb02459.x  0.153
1993 Raffa RB, Martinez RP, Connelly CD. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo Neuroscience Letters. 158: 87-91. PMID 8233078 DOI: 10.1016/0304-3940(93)90619-V  0.153
2006 Bruns IR, Chhum S, Dinh AT, Doerr H, Dunn NR, Ly YT, Mitman CL, Rickards HD, Sol C, Wan EW, Raffa RB. A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor: beta-arrestin2/G-protein coupling antagonists. Journal of Clinical Pharmacy and Therapeutics. 31: 119-28. PMID 16635045 DOI: 10.1111/j.1365-2710.2006.00714.x  0.153
1993 Nordberg LO, Raffa RB, Tallarida RJ. Determination of the drug-receptor dissociation constant of endothelin-1 using photorelaxation of rabbit isolated thoracic aorta. Life Sciences. 53: PL33-8. PMID 8321080 DOI: 10.1016/0024-3205(93)90682-S  0.152
2007 Rawls SM, Gomez T, Ding Z, Raffa RB. Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5). European Journal of Pharmacology. 575: 103-4. PMID 17765220 DOI: 10.1016/J.Ejphar.2007.07.060  0.152
1994 Codd EE, Press JB, Raffa RB. Alpha2-adrenoceptors vs. imidazoline receptors: Implications for analgesia and other non-cardiovascular therapeutic uses Life Sciences. 56: 63-74. DOI: 10.1016/0024-3205(94)00926-0  0.151
2015 Pergolizzi JV, Seow-Choen F, Wexner SD, Zampogna G, Raffa RB, Taylor R. Perspectives on Intravenous Oxycodone for Control of Postoperative Pain. Pain Practice : the Official Journal of World Institute of Pain. PMID 26393529 DOI: 10.1111/papr.12345  0.151
2012 Raffa RB, Gallo DA, Tallarida CS, Rawls SM, Tallarida RJ. Isobolographic Method and Invertebrate (Planarian) Model for Evaluating Combinations of Waterways Pollutants Pharmacology &Amp; Pharmacy. 3: 381-387. DOI: 10.4236/Pp.2012.34051  0.15
2015 Li Z, Pergolizzi JV, Huttner RP, Zampogna G, Breve F, Raffa RB. Management of opioid-induced constipation in pregnancy: a concise review with emphasis on the PAMORAs. Journal of Clinical Pharmacy and Therapeutics. PMID 26573866 DOI: 10.1111/jcpt.12331  0.15
1998 Kovelowski CJ, Raffa RB, Porreca F. Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus. European Journal of Pain (London, England). 2: 211-9. PMID 15102381 DOI: 10.1016/S1090-3801(98)90017-9  0.149
2009 Rawls SM, Thomas T, Adeola M, Patil T, Raymondi N, Poles A, Loo M, Raffa RB. Topiramate antagonizes NMDA- and AMPA-induced seizure-like activity in planarians. Pharmacology, Biochemistry, and Behavior. 93: 363-7. PMID 19447129 DOI: 10.1016/J.Pbb.2009.05.005  0.149
2002 Martinez RP, Raffa RB. LiCl attenuates M1AChR-mediated intrathecal pilocarpine-induced reciprocal hindlimb scratching in mice Pharmacology. 65: 210-214. PMID 12119451 DOI: 10.1159/000064346  0.148
1986 Raffa RB, Heyman J, Porreca F. Intrathecal FMRFamide (Phe-Met-Arg-Phe-NH2) induces excessive grooming behavior in mice Neuroscience Letters. 65: 94-98. PMID 2422608 DOI: 10.1016/0304-3940(86)90126-6  0.147
2015 Pergolizzi JV, Köknel Talu G, Zmponga G, Erdine S, Taylor R, Ayan B, Raffa RB. Maximizing value in opioid utilization: Is oxycodone immediate release a good option for pain management? AǧRı : ağRı (Algoloji) DerneğI'Nin YayıN OrganıDıR = the Journal of the Turkish Society of Algology. 27: 1-11. PMID 25867868  0.147
1986 Raffa RB, Porreca F. Evidence for a role of conditioning in the development of tolerance to morphine-induced inhibition of gastrointestinal transit in rats Neuroscience Letters. 67: 229-232. PMID 3737009 DOI: 10.1016/0304-3940(86)90313-7  0.146
1999 Bian D, Ossipov MH, Ibrahim M, Raffa RB, Tallarida RJ, Malan TP, Lai J, Porreca F. Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum. Brain Research. 831: 55-63. PMID 10411983 DOI: 10.1016/S0006-8993(99)01393-1  0.146
1996 Raffa RB, Codd EE. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life Sciences. 59: PL37-40. PMID 8699917 DOI: 10.1016/0024-3205(96)00273-1  0.145
2013 Raffa RB, Beckett JR, Brahmbhatt VN, Ebinger TM, Fabian CA, Nixon JR, Orlando ST, Rana CA, Tejani AH, Tomazic RJ. Orally active opioid compounds from a non-poppy source. Journal of Medicinal Chemistry. 56: 4840-8. PMID 23517479 DOI: 10.1021/jm400143z  0.145
2017 Raffa RB, Pawasauskas J, Pergolizzi JV, Lu L, Chen Y, Wu S, Jarrett B, Fain R, Hill L, Devarakonda K. Pharmacokinetics of Oral and Intravenous Paracetamol (Acetaminophen) When Co-Administered with Intravenous Morphine in Healthy Adult Subjects. Clinical Drug Investigation. PMID 29214506 DOI: 10.1007/s40261-017-0610-4  0.145
2001 Raffa RB. Pharmacology of oral combination analgesics: rational therapy for pain. Journal of Clinical Pharmacy and Therapeutics. 26: 257-64. PMID 11493367 DOI: 10.1046/j.1365-2710.2001.00355.x  0.143
2017 Raffa RB, Pergolizzi JV, LeQuang JA, Taylor R, Colucci S, Annabi MH. The fentanyl family: A distinguished medical history tainted by abuse. Journal of Clinical Pharmacy and Therapeutics. PMID 28980330 DOI: 10.1111/jcpt.12640  0.143
1999 Boyd RE, Press JB, Rasmussen CR, Raffa RB, Codd EE, Connelly CD, Bennett DJ, Kirifides AL, Gardocki JF, Reynolds B, Hortenstein JT, Reitz AB. Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles. Journal of Medicinal Chemistry. 42: 5064-71. PMID 10602691 DOI: 10.1021/jm990005a  0.142
2022 Miller TL, Raab LM, Shaffer TH, Schweikert A, Diana F, Fort P, Frum AS, Pergolizzi J, Raffa RB. A Novel Agnostic Respiratory Stimulant as a Treatment for Apnea of Prematurity: A Proof-of-Concept Study. Cureus. 14: e28900. PMID 36237747 DOI: 10.7759/cureus.28900  0.142
2016 Pergolizzi JV, Raffa RB, Zampogna G, Breve F, Colucci R, Schmidt WK, LeQuang JA. Comments and Suggestions from Pain Specialists Regarding the CDC's Proposed Opioid Guidelines. Pain Practice : the Official Journal of World Institute of Pain. 16: 794-808. PMID 27600924 DOI: 10.1111/papr.12475  0.142
2020 Raffa RB, Pergolizzi JV, Taylor R. “Atropisomeric” Drugs: Basic Concept and Example of Application to Drug Development Pharmacology &Amp; Pharmacy. 11: 1-8. DOI: 10.4236/pp.2020.111001  0.141
2000 Raffa RB, Wu C, Stone DJ, Borenstein MR, Codd EE, Coogan TP. Determination of the adsorption of tramadol hydrochloride by activated charcoal in vitro and in vivo. Journal of Pharmacological and Toxicological Methods. 43: 205-10. PMID 11257485 DOI: 10.1016/S1056-8719(00)00091-5  0.14
2011 Pergolizzi JV, Taylor R, Raffa RB. Extended-release formulations of tramadol in the treatment of chronic pain. Expert Opinion On Pharmacotherapy. 12: 1757-68. PMID 21609187 DOI: 10.1517/14656566.2011.576250  0.14
2009 Dhami H, Fritz CE, Gankin B, Pak SH, Yi W, Seya MJ, Raffa RB, Nagar S. The chemokine system and CCR5 antagonists: potential in HIV treatment and other novel therapies. Journal of Clinical Pharmacy and Therapeutics. 34: 147-60. PMID 19250135 DOI: 10.1111/j.1365-2710.2008.00978.x  0.14
2008 Raffa RB, Stone DJ. Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. The Journal of Pharmacology and Experimental Therapeutics. 325: 500-6. PMID 18292293 DOI: 10.1124/jpet.108.137273  0.139
2000 Baby S, Nguyen M, Tran D, Raffa RB. Substance P antagonists: the next breakthrough in treating depression? Journal of Clinical Pharmacy and Therapeutics. 24: 461-9. PMID 10651979 DOI: 10.1046/j.1365-2710.1999.00257.x  0.139
2010 Rawls SM, Karaca F, Madhani I, Bhojani V, Martinez RL, Abou-Gharbia M, Raffa RB. β-lactamase inhibitors display anti-seizure properties in an invertebrate assay. Neuroscience. 169: 1800-4. PMID 20600649 DOI: 10.1016/J.Neuroscience.2010.06.041  0.138
1989 Raffa RB, Ortegón ME, Watson M. Reciprocal hindlimb scratching and putative subtype-selective muscarinic agents. European Journal of Pharmacology. 158: 289-92. PMID 3253103 DOI: 10.1016/0014-2999(88)90082-9  0.136
2000 Hunsinger DM, Nguyen T, Zebraski SE, Raffa RB. Is there a basis for novel pharmacotherapy of autism? Life Sciences. 67: 1667-82. PMID 11021352 DOI: 10.1016/S0024-3205(00)00763-3  0.136
1989 Raffa RB, Mathiasen JR, Goode TL. Central administration of p-octopamine to mice: assessment of antinociception. European Journal of Pharmacology. 169: 317-20. PMID 2509222 DOI: 10.1016/0014-2999(89)90030-7  0.135
2016 Coluzzi F, Taylor R, Pergolizzi JV, Mattia C, Raffa RB. Good clinical practice guide for opioids in pain management: the three Ts - titration (trial), tweaking (tailoring), transition (tapering). Brazilian Journal of Anesthesiology (Elsevier). 66: 310-7. PMID 27108830 DOI: 10.1016/j.bjane.2014.09.005  0.134
2016 Coluzzi F, Taylor R, Pergolizzi JV, Mattia C, Raffa RB. [Good clinical practice guide for opioids in pain management: the three Ts - titration (trial), tweaking (tailoring), transition (tapering)]. Revista Brasileira De Anestesiologia. PMID 26993413 DOI: 10.1016/j.bjan.2016.02.008  0.134
2017 Pergolizzi JV, LeQuang JA, Taylor R, Raffa RB. The "Darknet": The new street for street drugs. Journal of Clinical Pharmacy and Therapeutics. PMID 28921578 DOI: 10.1111/jcpt.12628  0.134
2016 Pergolizzi JV, Zampogna G, Taylor R, Gonima E, Posada J, Raffa RB. A Guide for Pain Management in Low and Middle Income Communities. Managing the Risk of Opioid Abuse in Patients with Cancer Pain. Frontiers in Pharmacology. 7: 42. PMID 26973529 DOI: 10.3389/fphar.2016.00042  0.133
2000 Logani S, Chen MC, Tran T, Le T, Raffa RB. Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. Life Sciences. 67: 1389-96. PMID 10983836 DOI: 10.1016/S0024-3205(00)00741-4  0.133
2010 Raffa RB, Pergolizzi JV. The evolving understanding of the analgesic mechanism of action of flupirtine. Journal of Clinical Pharmacy and Therapeutics. 37: 4-6. PMID 21114508 DOI: 10.1111/j.1365-2710.2010.01233.x  0.132
2011 Vyas CA, Rawls SM, Raffa RB, Shackman JG. Glutamate and aspartate measurements in individual planaria by rapid capillary electrophoresis. Journal of Pharmacological and Toxicological Methods. 63: 119-22. PMID 20708699 DOI: 10.1016/J.Vascn.2010.08.002  0.131
1989 Raffa RB, Jacoby HI. FMRFamide enhances acetylcholine-induced contractions of guinea pig ileum. Peptides. 10: 693-5. PMID 2780424 DOI: 10.1016/0196-9781(89)90161-7  0.131
2017 Strasburger SE, Bhimani PM, Kaabe JH, Krysiak JT, Nanchanatt DL, Nguyen TN, Pough KA, Prince TA, Ramsey NS, Savsani KH, Scandlen L, Cavaretta MJ, Raffa RB. What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities. Journal of Clinical Pharmacy and Therapeutics. PMID 28111761 DOI: 10.1111/jcpt.12497  0.13
1982 Porreca F, Cowan A, Raffa RB, Tallarida RJ. Tolerance and cross-tolerance studies with morphine and ethylketocyclazocine Journal of Pharmacy and Pharmacology. 34: 666-667. PMID 6128391 DOI: 10.1111/J.2042-7158.1982.Tb04698.X  0.128
2019 Pergolizzi JV, LeQuang JA, Taylor R, Raffa RB. The Place of Community Rescue Naloxone in a Public Health Crisis of Opioid Overdose Pharmacology &Amp; Pharmacy. 10: 61-81. DOI: 10.4236/pp.2019.102006  0.128
1982 Raffa RB, O'Neill JJ, Tallarida RJ. Rapid extraction and measurement of morphine and opiate antagonists from rat brain using high-performance liquid chromatography and electrochemical detection. Journal of Chromatography. 238: 515-9. PMID 7096495 DOI: 10.1016/S0021-9673(00)81342-4  0.128
2018 Pergolizzi JV, Taylor R, LeQuang JA, Raffa RB, Bisney J. Tapentadol Extended Release in the Treatment of Severe Chronic Low Back Pain and Osteoarthritis Pain. Pain and Therapy. PMID 29623654 DOI: 10.1007/s40122-018-0095-8  0.127
2012 Raffa RB, Pergolizzi JV. Is morphine medicine's biggest misnomer? The Annals of Pharmacotherapy. 46: 1122-3. PMID 22764325 DOI: 10.1345/aph.1R133  0.127
2001 Boyd RE, Rasmussen CR, Press JB, Raffa RB, Codd EE, Connelly CD, Li QS, Martinez RP, Lewis MA, Almond HR, Reitz AB. α2 adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes Journal of Medicinal Chemistry. 44: 863-872. PMID 11300868 DOI: 10.1021/jm0003891  0.126
1982 Porreca F, Cowan A, Raffa RB, Tallarida RJ. On the criteria for classifying opiate agonists in rats Journal of Pharmacy and Pharmacology. 34: 525-526. PMID 6126567 DOI: 10.1111/J.2042-7158.1982.Tb04780.X  0.125
2020 Pergolizzi JV, LeQuang JA, Raffa RB. Benzodiazepines: Thinking outside the black box. Journal of Clinical Pharmacy and Therapeutics. PMID 33347636 DOI: 10.1111/jcpt.13333  0.125
2018 Sheng W, Raffa RB. Surprising Separation of Cannabinoid Physical Dependence and Withdrawal in an Invertebrate Model Pharmacology &Amp; Pharmacy. 9: 489-502. DOI: 10.4236/pp.2018.912038  0.124
2018 Raffa RB, Pergolizzi JV, Taylor R. The First Approved “Deuterated” Drug: A Short Review of the Concept Pharmacology &Amp; Pharmacy. 9: 440-446. DOI: 10.4236/PP.2018.910033  0.123
2015 Pergolizzi JV, Taylor R, Raffa RB. Intranasal ketorolac as part of a multimodal approach to postoperative pain. Pain Practice : the Official Journal of World Institute of Pain. 15: 378-88. PMID 25169467 DOI: 10.1111/papr.12239  0.123
2016 Pergolizzi JV, Raffa RB, Fleischer C, Zampogna G, Taylor R. Management of moderate to severe chronic low back pain with buprenorphine buccal film using novel bioerodible mucoadhesive technology. Journal of Pain Research. 9: 909-916. PMID 27826213 DOI: 10.2147/JPR.S87952  0.123
2010 Tallarida RJ, Cowan A, Raffa RB. On deriving the dose-effect relation of an unknown second component: an example using buprenorphine preclinical data. Drug and Alcohol Dependence. 109: 126-9. PMID 20061095 DOI: 10.1016/J.Drugalcdep.2009.12.014  0.121
2024 Raffa RB, Pergolizzi JV, Mathews J, Schatman ME. A New Rat Study Suggests There May Be a Biologic Explanation for Higher Fentanyl Mortality in Men Than in Women. Cureus. 16: e54354. PMID 38371439 DOI: 10.7759/cureus.54354  0.12
2010 Toussaint K, Yang XC, Zielinski MA, Reigle KL, Sacavage SD, Nagar S, Raffa RB. What do we (not) know about how paracetamol (acetaminophen) works? Journal of Clinical Pharmacy and Therapeutics. 35: 617-38. PMID 21054454 DOI: 10.1111/j.1365-2710.2009.01143.x  0.119
1989 Kimball ES, Raffa RB. Obligatory role of B cells and adherent accessory cells in the transfer of a defect in morphine-mediated antinociception in C57BL/6J-bg/bg (beige-J) mice. Journal of Neuroimmunology. 22: 185-92. PMID 2784797 DOI: 10.1016/0165-5728(89)90016-7  0.119
2018 Nalamachu S, Pergolizzi JV, Taylor R, Quang JAL, Pergolizzi JV, Raffa RB. Hormone Replacement Therapy for Restoring the HPG Axis in Pain Patients Treated with Long-Term Opioid Analgesics Pharmacology &Amp; Pharmacy. 9: 473-480. DOI: 10.4236/pp.2018.911036  0.117
2011 Walker EA, Foley JJ, Clark-Vetri R, Raffa RB. Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice. Psychopharmacology. 217: 539-48. PMID 21537942 DOI: 10.1007/s00213-011-2310-8  0.116
2001 Raffa RB, Stone DJ, Tallarida RJ. Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine. European Journal of Pharmacology. 412: R1-2. PMID 11165231 DOI: 10.1016/S0014-2999(01)00722-1  0.115
1991 Raffa RB, Vaught JL, Setler PE. The novel anticonvulsant loreclezole (R 72063) does not produce diazepam-like anterograde amnesia in a passive avoidance test in rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 342: 613-5. PMID 2090955 DOI: 10.1007/BF00169053  0.113
2012 Taylor R, Raffa RB, Pergolizzi JV. Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature. Journal of Pain Research. 5: 77-87. PMID 22570559 DOI: 10.2147/JPR.S21965  0.111
2016 Pergolizzi JV, Raffa RB, Nalamachu S, Taylor R. Evolution to low-dose NSAID therapy. Pain Management. PMID 26980438 DOI: 10.2217/pmt.15.69  0.108
2013 Taylor R, Pergolizzi JV, Raffa RB. Tapentadol extended release for chronic pain patients. Advances in Therapy. 30: 14-27. PMID 23328938 DOI: 10.1007/s12325-013-0002-y  0.108
2015 Drewniany E, Han J, Hancock C, Jones RL, Lim J, Nemat Gorgani N, Sperry JK, Yu HJ, Raffa RB. Rapid-onset antidepressant action of ketamine: potential revolution in understanding and future pharmacologic treatment of depression. Journal of Clinical Pharmacy and Therapeutics. 40: 125-30. PMID 25545040 DOI: 10.1111/jcpt.12238  0.108
2018 Raffa RB, Pergolizzi JV, Taylor R, Ossipov MH. Discovery of "folded DNA" structures in human cells: Potential drug targets. Journal of Clinical Pharmacy and Therapeutics. PMID 30144395 DOI: 10.1111/jcpt.12758  0.108
2014 Raffa RB, Pergolizzi JV, Taylor R, Decker JF, Patrick JT. Acetaminophen (paracetamol) oral absorption and clinical influences. Pain Practice : the Official Journal of World Institute of Pain. 14: 668-77. PMID 26013309 DOI: 10.1111/papr.12130  0.106
2012 Pergolizzi JV, van de Laar M, Langford R, Mellinghoff HU, Merchante IM, Nalamachu S, O'Brien J, Perrot S, Raffa RB. Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain. Journal of Pain Research. 5: 327-46. PMID 23055775 DOI: 10.2147/JPR.S33112  0.106
2019 Raffa RB, Pergolizzi JV. Directing the Metabolism of Drugs Away from CYP450: The Use of Oxetane Rings Pharmacology &Amp; Pharmacy. 10: 465-473. DOI: 10.4236/pp.2019.1011038  0.105
2013 Taylor R, Pergolizzi JV, Sinclair A, Raffa RB, Aldington D, Plavin S, Apfel CC. Transversus abdominis block: clinical uses, side effects, and future perspectives. Pain Practice : the Official Journal of World Institute of Pain. 13: 332-44. PMID 22967210 DOI: 10.1111/j.1533-2500.2012.00595.x  0.104
2010 Raffa RB. A proposed mechanism for chemotherapy-related cognitive impairment ('chemo-fog'). Journal of Clinical Pharmacy and Therapeutics. 36: 257-9. PMID 21545608 DOI: 10.1111/j.1365-2710.2010.01188.x  0.104
2016 Lin TC, Ger LP, Pergolizzi JV, Raffa RB, Wang JO, Ho ST. Knowledge, Attitude and Practice Survey of Prescribing Opioids for Chronic Noncancer Pain in Taiwan-Comparison of Pain and Non-Pain Physicians. Pain Medicine (Malden, Mass.). PMID 27550948 DOI: 10.1093/pm/pnw189  0.104
2010 Raffa RB, Tallarida RJ. Effects on the visual system might contribute to some of the cognitive deficits of cancer chemotherapy-induced 'chemo-fog'. Journal of Clinical Pharmacy and Therapeutics. 35: 249-55. PMID 20831527 DOI: 10.1111/j.1365-2710.2009.01086.x  0.101
2010 Morlion B, Pergolizzi JV, Raffa RB. European perspectives on upcoming analgesics: What do they have that we don't—and what do they think about them? Techniques in Regional Anesthesia and Pain Management. 14: 86-98. DOI: 10.1053/j.trap.2010.03.002  0.1
2015 Coluzzi F, Pergolizzi J, Raffa RB, Mattia C. The unsolved case of "bone-impairing analgesics": the endocrine effects of opioids on bone metabolism. Therapeutics and Clinical Risk Management. 11: 515-23. PMID 25848298 DOI: 10.2147/TCRM.S79409  0.1
1992 Raffa RB, Aceto JF, Goldschmidt JE, Tallarida RJ. The effect of lowered extracellular Na+ concentration on ultraviolet light-induced relaxation of vasoconstricted rabbit isolated thoracic aorta. Life Sciences. 51: PL249-54. PMID 1453873 DOI: 10.1016/0024-3205(92)90118-9  0.098
2012 Pergolizzi JV, Philip BK, Leslie JB, Taylor R, Raffa RB. Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting. Journal of Clinical Anesthesia. 24: 334-45. PMID 22608591 DOI: 10.1016/j.jclinane.2011.07.019  0.097
1992 Carson JR, Carmosin RJ, Vaught JL, Gardocki JF, Costanzo MJ, Raffa RB, Almond HR. 2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents. Journal of Medicinal Chemistry. 35: 2855-63. PMID 1495016 DOI: 10.1021/jm00093a019  0.097
2009 Pergolizzi JV, Raffa RB, Gould E. Considerations on the use of oxymorphone in geriatric patients. Expert Opinion On Drug Safety. 8: 603-13. PMID 19614559 DOI: 10.1517/14740330903153854  0.096
2011 Rawls SM, Patil T, Tallarida CS, Baron S, Kim M, Song K, Ward S, Raffa RB. Nicotine behavioral pharmacology: clues from planarians. Drug and Alcohol Dependence. 118: 274-9. PMID 21530106 DOI: 10.1016/J.Drugalcdep.2011.04.001  0.094
2011 Pappagallo M, Leslie JB, Raffa RB, Kash P, Fleischer C, Sinclair N, Labhestwar S, Di Lorenzo L, Tabor A. Evaluation of a novel topical essential oxygen oil for the treatment of pain in acute tendinopathy and sprains. Muscles, Ligaments and Tendons Journal. 1: 25-30. PMID 23738241  0.094
1991 Raffa RB, Jacoby HI. Endothelin-1, -2 and -3 directly and big-endothelin-1 indirectly elicit an abdominal constriction response in mice. Life Sciences. 48: PL85-90. PMID 1826753 DOI: 10.1016/0024-3205(91)90130-4  0.093
2020 Pergolizzi JV, Raffa RB, Varrassi G, Magnusson P, LeQuang JA, Paladini A, Taylor R, Wollmuth C, Breve F, Chopra M, Nalamasu R, Christo PJ. Potential Neurological Manifestations of COVID-19: A Narrative Review. Postgraduate Medicine. PMID 33089707 DOI: 10.1080/00325481.2020.1837503  0.091
2003 Raffa RB, Clark-Vetri R, Tallarida RJ, Wertheimer AI. Combination strategies for pain management. Expert Opinion On Pharmacotherapy. 4: 1697-708. PMID 14521480 DOI: 10.1517/14656566.4.10.1697  0.087
1985 Aceto JF, Kitzen J, Raffa RB, Tallarida RJ. Altered vascular responsiveness to norepinephrine following withdrawal of verapamil in rabbits. Journal of Cardiovascular Pharmacology. 7: 1011-2. PMID 2413285 DOI: 10.1097/00005344-198509000-00033  0.087
1999 Raffa RB. Possible role(s) of neurokinins in CNS development and neurodegenerative or other disorders. Neuroscience and Biobehavioral Reviews. 22: 789-813. PMID 9809312 DOI: 10.1016/S0149-7634(97)00070-5  0.086
1987 Raffa RB, Mathiasen JR, Vaught JL. Restoration of analgesic response of C57BL/6J-bgJ (beige-J) mice to morphine by carbachol. European Journal of Pharmacology. 141: 507-10. PMID 3666044 DOI: 10.1016/0014-2999(87)90575-9  0.086
1988 Raffa RB, Kimball ES, Mathiasen JR. The analgesic defect of C57BL/6J-bgJ/bgJ (beige-J: Chediak-Higashi syndrome) mice transmitted by adoptive transfer of spleen cells to normal littermates. Life Sciences. 42: 1231-6. PMID 3347148 DOI: 10.1016/0024-3205(88)90554-1  0.086
2008 Foley JJ, Raffa RB, Walker EA. Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory. Psychopharmacology. 199: 527-38. PMID 18463849 DOI: 10.1007/s00213-008-1175-y  0.086
1998 Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-fq/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats European Journal of Pain. 2: 267-280. DOI: 10.1016/S1090-3801(98)90023-4  0.085
2012 Raffa RB, Tallarida RJ, Taylor R, Pergolizzi JV. Fixed-dose combinations for emerging treatment of pain. Expert Opinion On Pharmacotherapy. 13: 1261-70. PMID 22420908 DOI: 10.1517/14656566.2012.668531  0.082
1994 Wild KD, Press JB, Raffa RB. Alpha2-Adrenoceptors: Can Subtypes Mediate Selective Analgesia? Analgesia. 1: 15-25. DOI: 10.3727/107156994819564384  0.081
2018 Kitzen JM, Pergolizzi Jr. JV, Taylor Jr. R, Raffa RB. The Role of Medical Literature, Clinical Trials and Experimental Research in Drug Product-Injury Litigation: A Primer with Two Examples Pharmacology &Amp; Pharmacy. 9: 208-227. DOI: 10.4236/pp.2018.96016  0.08
2002 Wu WN, McKown LA, Gauthier AD, Jones WJ, Raffa RB. Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 31: 423-41. PMID 11531006 DOI: 10.1080/00498250110057378  0.079
2010 Raffa RB. Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment. Journal of Clinical Pharmacy and Therapeutics. 36: 437-45. PMID 21729110 DOI: 10.1111/j.1365-2710.2010.01208.x  0.077
2011 Akter K, Lanza EA, Martin SA, Myronyuk N, Rua M, Raffa RB. Diabetes mellitus and Alzheimer's disease: shared pathology and treatment? British Journal of Clinical Pharmacology. 71: 365-76. PMID 21284695 DOI: 10.1111/j.1365-2125.2010.03830.x  0.076
2003 Raffa RB. Mechanism of action of analgesics used to treat osteoarthritis pain. Rheumatic Diseases Clinics of North America. 29: 733-45. PMID 14603580 DOI: 10.1016/S0889-857X(03)00058-9  0.076
2016 Pergolizzi JV, Paladini A, Varrassi G, Raffa RB. Change Pain: Ever Evolving-An Update for 2016. Pain and Therapy. PMID 27743137 DOI: 10.1007/s40122-016-0058-x  0.076
2013 Yarlas A, Miller K, Wen W, Dain B, Lynch SY, Pergolizzi JV, Raffa RB, Ripa SR. A randomized, placebo-controlled study of the impact of the 7-day buprenorphine transdermal system on health-related quality of life in opioid-naïve patients with moderate-to-severe chronic low back pain. The Journal of Pain : Official Journal of the American Pain Society. 14: 14-23. PMID 23200931 DOI: 10.1016/j.jpain.2012.09.016  0.076
2013 Pergolizzi JV, Raffa RB, Taylor R, Rodriguez G, Nalamachu S, Langley P. A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic osteoarthritis pain and low back pain. Pain Practice : the Official Journal of World Institute of Pain. 13: 239-52. PMID 22716295 DOI: 10.1111/j.1533-2500.2012.00578.x  0.076
2006 Raffa RB, Jacoby HI. Endothelin antagonists in CION injury model Pain. 126: 322. PMID 16938396 DOI: 10.1016/j.pain.2006.07.013  0.075
2001 Tao Q, Stone DJ, Borenstein MR, Jean-Bart V, Codd EE, Coogan TP, Desai-Krieger D, Liao S, Raffa RB. Gas chromatographic method using nitrogen-phosphorus detection for the measurement of tramadol and its O-desmethyl metabolite in plasma and brain tissue of mice and rats. Journal of Chromatography. B, Biomedical Sciences and Applications. 763: 165-71. PMID 11710575 DOI: 10.1016/S0378-4347(01)00388-7  0.073
2012 Pergolizzi JV, Raffa RB, Taylor R, Nagar S, Labhsetwar S, Sinclair N, Gould EM. An open-label pharmacokinetic study of oxymorphone extended release in the presence of naltrexone in the older adult. Journal of Opioid Management. 8: 383-93. PMID 23264316 DOI: 10.5055/jom.2012.0138  0.073
2013 Morón Merchante I, Pergolizzi JV, van de Laar M, Mellinghoff HU, Nalamachu S, O'Brien J, Perrot S, Raffa RB. Tramadol/Paracetamol fixed-dose combination for chronic pain management in family practice: a clinical review. Isrn Family Medicine. 2013: 638469. PMID 24959571 DOI: 10.5402/2013/638469  0.072
2005 Farrell M, Raffa R, Walker E. B120 BEHAVIORAL EFFECTS OF SEROTONIN IN PLANARIA Behavioural Pharmacology. 16: S104. DOI: 10.1097/00008877-200509001-00325  0.072
2012 Akter K, Gallo DA, Martin SA, Myronyuk N, Roberts RT, Stercula K, Raffa RB. A review of the possible role of the essential fatty acids and fish oils in the aetiology, prevention or pharmacotherapy of schizophrenia. Journal of Clinical Pharmacy and Therapeutics. 37: 132-9. PMID 21501206 DOI: 10.1111/j.1365-2710.2011.01265.x  0.068
2005 Raffa RB. Analgesic Patent Applications: I Reviews in Analgesia. 8: 71-84. DOI: 10.3727/000000005783992917  0.068
2012 van Laar M, Pergolizzi JV, Mellinghoff HU, Merchante IM, Nalamachu S, O'Brien J, Perrot S, Raffa RB. Pain treatment in arthritis-related pain: beyond NSAIDs. The Open Rheumatology Journal. 6: 320-30. PMID 23264838 DOI: 10.2174/1874312901206010320  0.068
2010 Raffa RB, Pergolizzi JV. Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example. Journal of Clinical Pharmacy and Therapeutics. 36: 283-98. PMID 21545611 DOI: 10.1111/j.1365-2710.2010.01190.x  0.068
2002 Raffa RB. Acetaminophen and metabolite: lack of effect on nitric oxide synthase (constitutive or inducible). Headache. 42: 237-8. PMID 11903555 DOI: 10.1046/j.1526-4610.2002.02063.x  0.067
2021 Hunt AM, Fachner J, Clark-Vetri R, Raffa RB, Rupnow-Kidd C, Maidhof C, Dileo C. Neuronal Effects of Listening to Entrainment Music Versus Preferred Music in Patients With Chronic Cancer Pain as Measured via EEG and LORETA Imaging. Frontiers in Psychology. 12: 588788. PMID 33716859 DOI: 10.3389/fpsyg.2021.588788  0.066
2005 Yue H, Borenstein MR, Jansen SA, Raffa RB. Liquid chromatography-mass spectrometric analysis of buprenorphine and its N-dealkylated metabolite norbuprenorphine in rat brain tissue and plasma. Journal of Pharmacological and Toxicological Methods. 52: 314-22. PMID 15935707 DOI: 10.1016/J.Vascn.2005.04.012  0.065
2010 Raffa RB, Martin KJ. Patient's perspective. Advances in Experimental Medicine and Biology. 678: 11-2. PMID 20738000  0.065
2018 Pergolizzi JV, Lequang JA, Taylor R, Raffa RB, Colucci D. The role of cannabinoids in pain control: the good, the bad, and the ugly. Minerva Anestesiologica. PMID 29338150 DOI: 10.23736/S0375-9393.18.12287-5  0.064
2021 Pergolizzi JV, Varrassi G, Magnusson P, Breve F, Raffa RB, Christo PJ, Chopra M, Paladini A, LeQuang JA, Mitchell K, Coluzzi F. Pharmacologic agents directed at the treatment of pain associated with maladaptive neuronal plasticity. Expert Opinion On Pharmacotherapy. 1-12. PMID 34461795 DOI: 10.1080/14656566.2021.1970135  0.062
2010 Raffa RB. Is a picture worth a thousand (forgotten) words?: neuroimaging evidence for the cognitive deficits in 'chemo-fog'/'chemo-brain'. Journal of Clinical Pharmacy and Therapeutics. 35: 1-9. PMID 20175809 DOI: 10.1111/j.1365-2710.2009.01044.x  0.06
2006 Wu WN, McKown LA, Codd EE, Raffa RB. Metabolism of two analgesic agents, tramadol-n-oxide and tramadol, in specific pathogen-free and axenic mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 36: 551-65. PMID 16769648 DOI: 10.1080/00498250600653372  0.058
2012 Taylor R, Gan TJ, Raffa RB, Gharibo C, Pappagallo M, Sinclair NR, Fleischer C, Tabor A. A randomized, double-blind comparison shows the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain demonstrates incremental benefit over time. Pain Practice : the Official Journal of World Institute of Pain. 12: 610-9. PMID 22304620 DOI: 10.1111/j.1533-2500.2012.00529.x  0.057
2010 Raffa RB, Martin KJ. Patient's perspective Advances in Experimental Medicine and Biology. 678: 11-12. DOI: 10.1007/978-1-4419-6306-2_2  0.057
2011 Raffa RB, Porreca F. The pain chronicles Journal of Clinical Investigation. 121: 825-825. DOI: 10.1172/JCI45953  0.057
2021 Peppin JF, Pergolizzi JV, Gan TJ, Raffa RB. The problem of postoperative respiratory depression. Journal of Clinical Pharmacy and Therapeutics. PMID 33655504 DOI: 10.1111/jcpt.13382  0.055
2018 Kitzen JM, Pergolizzi Jr. JV, Taylor Jr. R, Raffa RB. Crisaborole and Apremilast: PDE4 Inhibitors with Similar Mechanism of Action, Different Indications for Management of Inflammatory Skin Conditions Pharmacology &Amp; Pharmacy. 9: 357-381. DOI: 10.4236/PP.2018.99028  0.053
2014 Pergolizzi JV, Taylor R, Nalamachu S, Raffa RB, Carlson DR, Varanasi RK, Kopecky EA. Challenges of treating patients with chronic pain with dysphagia (CPD): physician and patient perspectives. Current Medical Research and Opinion. 30: 191-202. PMID 24117419 DOI: 10.1185/03007995.2013.854197  0.053
2014 Pergolizzi JV, Raffa RB, Taylor R. Treating acute pain in light of the chronification of pain. Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses. 15: 380-90. PMID 24602441 DOI: 10.1016/j.pmn.2012.07.004  0.052
1995 Wild KD, Raffa RB. Current Research in Analgesia IV to VI. Aug. 8, 1994–Feb. 27, 1995 Analgesia. 1: 211-242. DOI: 10.3727/107156995819563410  0.052
2012 Raffa RB, Breve F, Jr. RT, Jr. JVP. Vitamin D and Number of Falls in a Long-Term Care Facility Pharmacology &Amp; Pharmacy. 3: 453-457. DOI: 10.4236/PP.2012.34061  0.051
2002 Tao Q, Stone DJ, Borenstein MR, Codd EE, Coogan TP, Desai-Krieger D, Liao S, Raffa RB. Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally. Journal of Clinical Pharmacy and Therapeutics. 27: 99-106. PMID 11975693 DOI: 10.1046/J.1365-2710.2002.00384.X  0.05
1998 Wild KD, Raffa RB. Current Research in Analgesia XIII. Oct 1996 - Jan 1997 Analgesia. 3: 307-493. DOI: 10.3727/107156998819565910  0.049
2011 Taylor R, Pergolizzi JV, Raffa RB, Muniz E. 009. Safe use of fluoroquinolones: A focus on limiting CNS and peripheral neuropathy adverse events European Journal of Pain Supplements. 5: 510-510. DOI: 10.1016/j.eujps.2011.08.032  0.048
2014 Pergolizzi JV, Taylor R, Raffa RB, Nalamachu S, Chopra M. Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness. Sleep Disorders. 2014: 527109. PMID 24649369 DOI: 10.1155/2014/527109  0.046
2005 Craig MA, Beppler GA, Santos C, Raffa RB. A second (non-genomic) steroid mechanism of action: possible opportunity for novel pharmacotherapy? Journal of Clinical Pharmacy and Therapeutics. 30: 305-12. PMID 15985043 DOI: 10.1111/j.1365-2710.2005.00664.x  0.046
1995 Wild KD, Raffa RB. Current Research in Analgesia III. July 18–August 1, 1994 Analgesia. 1: 145-150. DOI: 10.3727/107156995819564211  0.045
1994 Wild KD, Raffa RB. Current Research in Analgesia I. May 1–June 6, 1994 Analgesia. 1: 1-9. DOI: 10.3727/107156994819564410  0.045
2011 Taylor R, Gan TJ, Raffa RB, Gharibo C, Pappagallo M, Sinclair NR, Fleischer C, Tabor A. 007. A randomized, double-blind comparison of the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain European Journal of Pain Supplements. 5: 509-510. DOI: 10.1016/j.eujps.2011.08.030  0.044
1997 Wild KD, Raffa RB. Current Research in Analgesia XI. March 19 - June 29, 1996 Analgesia. 3: 51-100. DOI: 10.3727/107156997819566073  0.044
1996 Wild KD, Raffa RB. Current Research in Analgesia VII. Feb. 28 - April 10, 1995 Analgesia. 2: 1-10. DOI: 10.3727/107156996819564832  0.044
1999 Wild KD, Raffa RB. Current Research in Analgesia XIV. January - July 1,1997 Analgesia. 4: 33-171. DOI: 10.3727/107156999819565874  0.044
1999 McCary JD, Wild KD, Raffa RB. Current Research in Analgesia XV. July - December 1997 Analgesia. 4: 197-375. DOI: 10.3727/107156999819565810  0.043
2019 Pergolizzi JV, Raffa RB, Paladini A, Varrasi G, LeQuang JA. Treating pain in patients with dementia and the possible concomitant relief of symptoms of agitation. Pain Management. 9: 569-582. PMID 31755371 DOI: 10.2217/pmt-2019-0024  0.042
2013 Raffa RB. Cancer 'survivor-care': II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment). Journal of Clinical Pharmacy and Therapeutics. 38: 265-8. PMID 23656522 DOI: 10.1111/jcpt.12071  0.042
2015 Yarlas A, Miller K, Wen W, Lynch SY, Ripa SR, Pergolizzi JV, Raffa RB. Buprenorphine Transdermal System Improves Sleep Quality and Reduces Sleep Disturbance in Patients with Moderate-to-Severe Chronic Low Back Pain: Results from Two Randomized Controlled Trials. Pain Practice : the Official Journal of World Institute of Pain. PMID 25599968 DOI: 10.1111/papr.12281  0.042
2003 Bassi N, Cohen AR, Desai S, Espinosa MG, Flynn EE, Franchetti KE, Kuriakose A, Lam ST, Ly KS, McGraw MJ, Namazi NN, Nemeh GA, Oliva CD, Pastakia SD, Riley KM, ... ... Raffa RB, et al. Critical Evaluation of Reported Plant Sources of Possibly Novel Analgesic Compounds Reviews in Analgesia. 7: 97-117. DOI: 10.3727/000000003783992973  0.041
2016 Pergolizzi JV, Raffa RB, Marcum Z, Colucci S, Ripa SR. Safety of Buprenorphine Transdermal System in the Management of Pain in Older Adults. Postgraduate Medicine. PMID 27929709 DOI: 10.1080/00325481.2017.1270699  0.04
1999 McCary JD, Wild KD, Raffa RB. Current Research in Analgesia XVI. January – December 1998 Analgesia. 4: 409-459. DOI: 10.3727/107156999819565793  0.04
2012 Raffa RB, Eltoukhy NS, Raffa KF. Implications of climate change (global warming) for the healthcare system. Journal of Clinical Pharmacy and Therapeutics. 37: 502-4. PMID 22591287 DOI: 10.1111/J.1365-2710.2012.01355.X  0.04
2018 Raffa RB, Pergolizzi JV, Taylor R, Kitzen JM. Sunscreen bans: Coral reefs and skin cancer. Journal of Clinical Pharmacy and Therapeutics. PMID 30484882 DOI: 10.1111/jcpt.12778  0.039
1995 Wild KD, Raffa RB. Current Research in Analgesia II. June 7–July 11, 1994 Analgesia. 1: 83-90. DOI: 10.3727/107156995819564329  0.039
2019 Pergolizzi JV, Taylor R, LeQuang JA, Gould E, Raffa RB. Treating Insomnia in Older Adult Patients: Limiting Benzodiazepine Use Pharmacology &Amp; Pharmacy. 10: 116-129. DOI: 10.4236/PP.2019.103010  0.039
2002 Raffa RG, Raivio TL. A third envelope stress signal transduction pathway in Escherichia coli. Molecular Microbiology. 45: 1599-611. PMID 12354228 DOI: 10.1046/j.1365-2958.2002.03112.x  0.038
2015 Coluzzi F, Raffa RB, Pergolizzi J, Rocco A, Locarini P, Cenfra N, Cimino G, Mattia C. Tapentadol prolonged release for patients with multiple myeloma suffering from moderate-to-severe cancer pain due to bone disease. Journal of Pain Research. 8: 229-38. PMID 26064064 DOI: 10.2147/JPR.S83490  0.037
1986 Raffa RB, Paul Bianchi C. Further evidence for a neuromodulatory role of fmrfamide involving intracellular ca2+ pools in smooth muscle of mytilus edulis Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 84: 23-28. DOI: 10.1016/0742-8413(86)90159-3  0.036
2022 Pergolizzi J, Kraus A, Magnusson P, Breve F, Mitchell K, Raffa R, LeQuang JAK, Varrassi G. Treating Apnea of Prematurity. Cureus. 14: e21783. PMID 35251853 DOI: 10.7759/cureus.21783  0.036
2010 Raffa RB. Diselenium, instead of disulfide, bonded analogs of conotoxins: novel synthesis and pharmacotherapeutic potential. Life Sciences. 87: 451-6. PMID 20691706 DOI: 10.1016/j.lfs.2010.07.011  0.036
2020 Grundmann O, Babin JK, Henningfield JE, Garcia-Romeu A, Kruegel AC, Prozialeck WC, Raffa RB, Singh D, Smith KE. Kratom Use in the United States: A Diverse and Complex Profile. Addiction (Abingdon, England). PMID 32602213 DOI: 10.1111/Add.15173  0.034
2014 Taylor R, Pergolizzi JV, Raffa RB, Nalamachu S, Balestrieri PJ. Pain and obesity in the older adult. Current Pharmaceutical Design. 20: 6037-41. PMID 24641223  0.033
2020 Peppin JF, Raffa RB, Schatman ME. The Polysubstance Overdose-Death Crisis. Journal of Pain Research. 13: 3405-3408. PMID 33364823 DOI: 10.2147/JPR.S295715  0.031
1997 Raffa RB. Comments on Carmody, Pain, 63 (1995) 136. Pain. 67: 215-8. PMID 8895252 DOI: 10.1016/0304-3959(96)03148-X  0.03
2020 Umeda-Raffa S, Pergolizzi JV, Raffa RB. Bone fractures during the time of coronavirus. Journal of Clinical Pharmacy and Therapeutics. PMID 33104253 DOI: 10.1111/jcpt.13297  0.029
2013 Mikulca JA, Nguyen V, Gajdosik DA, Teklu SG, Giunta EA, Lessa EA, Tran CH, Terak EC, Raffa RB. Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches. Journal of Clinical Pharmacy and Therapeutics. 39: 25-37. PMID 24313554 DOI: 10.1111/jcpt.12112  0.028
2010 Raffa RB, Tallarida RJ. Future directions. Advances in Experimental Medicine and Biology. 678: 165-7. PMID 20738019  0.028
2019 Kitzen JM, McConaha JL, Bookser ML, Pergolizzi JV, Taylor R, Raffa RB. e-Cigarettes for smoking cessation: Do they deliver? Journal of Clinical Pharmacy and Therapeutics. PMID 30950094 DOI: 10.1111/jcpt.12833  0.025
2010 Raffa RB. Short introduction and history. Advances in Experimental Medicine and Biology. 678: 1-10. PMID 20737999  0.022
2006 Raffa RB, Duong PV, Finney J, Garber DA, Lam LM, Mathew SS, Patel NN, Plaskett KC, Shah M, Jen Weng HF. Is 'chemo-fog'/'chemo-brain' caused by cancer chemotherapy? Journal of Clinical Pharmacy and Therapeutics. 31: 129-38. PMID 16635046 DOI: 10.1111/j.1365-2710.2006.00726.x  0.022
2023 Tey A, Schwarer J, Raffa R, Shi E, Paul E, Opat S, Dendle C, Shortt J. High risk of infection in 'real-world' patients receiving ibrutinib, idelalisib or venetoclax for mature B-cell leukaemia/lymphoma. European Journal of Haematology. PMID 36656100 DOI: 10.1111/ejh.13928  0.021
2015 Goldberg EJ, Bhalodia S, Jacob S, Patel H, Trinh KV, Varghese B, Yang J, Young SR, Raffa RB. Clostridium difficile infection: A brief update on emerging therapies. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 72: 1007-12. PMID 26025991 DOI: 10.2146/ajhp140645  0.021
2010 Raffa RB. Imaging as a means of studying chemotherapy-related cognitive impairment. Advances in Experimental Medicine and Biology. 678: 70-6. PMID 20738008  0.019
1985 Raffa RB. Coated pits and coated vesicles: histological findings and pharmacological implications Trends in Pharmacological Sciences. 6: 133-136. DOI: 10.1016/0165-6147(85)90058-6  0.018
2002 Maiorini AF, Gaunt MJ, Jacobsen TM, McKay AE, Waldman LD, Raffa RB. Potential novel targets for Alzheimer pharmacotherapy: I. Secretases. Journal of Clinical Pharmacy and Therapeutics. 27: 169-83. PMID 12081630 DOI: 10.1046/j.1365-2710.2002.00415.x  0.017
2002 Raffa RB. An Elective Course on Writing and Publishing a Review Article Pharmacy Education. 2: 51-58. DOI: 10.1080/1560221021000010982  0.017
2010 Raffa RB, Tallarida RJ. Chemo fog: cancer chemotherapy-related cognitive impairment. Preface. Advances in Experimental Medicine and Biology. 678: vii-viii. PMID 20737998  0.017
2018 Raffa RB, Pergolizzi JV, Taylor R, Choudhuri S, Rodenbeck R. Persistence of Healthcare-Associated (Nosocomial) Infections Due to Inadequate Hand Hygiene: Part 1—Biological and Treatment Factors Pharmacology &Amp; Pharmacy. 9: 293-309. DOI: 10.4236/pp.2018.98023  0.011
1998 Bennett DA, Phun L, Polk JF, Voglino SA, Zlotnik V, Raffa RB. Neuropharmacology of St. John's Wort (Hypericum). The Annals of Pharmacotherapy. 32: 1201-8. PMID 9825087 DOI: 10.1345/aph.18026  0.011
2010 Raffa RB. Chemotherapy-related visual system toxicity. Advances in Experimental Medicine and Biology. 678: 113-8. PMID 20738012  0.011
2022 Pergolizzi JV, Fort P, Miller TL, LeQuang JA, Raffa RB. The epidemiology of apnoea of prematurity. Journal of Clinical Pharmacy and Therapeutics. PMID 35018653 DOI: 10.1111/jcpt.13587  0.01
2021 Pergolizzi JV, Fort P, Miller TL, LeQuang JA, Raffa RB. The limited management options for apnoea of prematurity. Journal of Clinical Pharmacy and Therapeutics. PMID 34734423 DOI: 10.1111/jcpt.13547  0.01
2020 Pergolizzi J, LeQuang JA, Umeda-Raffa S, Fleischer C, Pergolizzi J, Pergolizzi C, Raffa RB. The Zika virus: Lurking behind the COVID-19 pandemic? Journal of Clinical Pharmacy and Therapeutics. PMID 33217046 DOI: 10.1111/jcpt.13310  0.01
2019 Raffa RB, Westfield G. More Rapid Sleep Onset with Lingual-Spray vs Oral-Tablet Delivery Zolpidem Pharmacology &Amp; Pharmacy. 10: 329-342. DOI: 10.4236/PP.2019.107027  0.01
2018 Raffa RB, Pergolizzi JV, Taylor R, Choudhuri S, Rodenbeck R. Persistence of Healthcare-Associated (Nosocomial) Infections Due to Inadequate Hand Hygiene: Part 3—Application of Human Factors Engineering to an Ozone Hand Sanitizer Pharmacology &Amp; Pharmacy. 9: 324-330. DOI: 10.4236/pp.2018.98025  0.01
2018 Raffa RB, Pergolizzi JV, Taylor R, Choudhuri S, Rodenbeck R. Persistence of Healthcare-Associated (Nosocomial) Infections Due to Inadequate Hand Hygiene: Part 2—Human Factors Pharmacology &Amp; Pharmacy. 9: 310-323. DOI: 10.4236/pp.2018.98024  0.01
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