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Theodore Slotkin - Publications

Affiliations: 
Duke University, Durham, NC 
Area:
Pharmacology, Toxicology, Neuroscience Biology
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Year Citation  Score
2021 Slotkin TA, Levin ED, Seidler FJ. Paternal Cannabis Exposure Prior to Mating, but Not Δ9-Tetrahydrocannabinol, Elicits Deficits in Dopaminergic Synaptic Activity in the Offspring. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 34590702 DOI: 10.1093/toxsci/kfab117  0.377
2021 Hawkey AB, Holloway Z, Dean C, Koburov R, Slotkin TA, Seidler FJ, Levin ED. Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact? Neurotoxicology and Teratology. 106985. PMID 33901621 DOI: 10.1016/j.ntt.2021.106985  0.329
2020 Slotkin TA, Skavicus S, Levin ED, Seidler FJ. Paternal Δ9-Tetrahydrocannabinol Exposure Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in the Offspring. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32077955 DOI: 10.1093/toxsci/kfaa004  0.431
2020 Hawkey AB, Glazer L, Dean C, Wells CN, Odamah KA, Slotkin TA, Seidler FJ, Levin ED. Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. Neurotoxicology and Teratology. 106853. PMID 31911208 DOI: 10.1016/j.ntt.2019.106853  0.322
2019 Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. PERINATAL DIAZINON EXPOSURE COMPROMISES THE DEVELOPMENT OF ACETYLCHOLINE AND SEROTONIN SYSTEMS. Toxicology. 152240. PMID 31251962 DOI: 10.1016/j.tox.2019.152240  0.398
2018 Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30247698 DOI: 10.1093/toxsci/kfy241  0.376
2018 Cauley M, Hall BJ, Abreu-Villaça Y, Junaid S, White H, Kiany A, Slotkin TA, Levin ED. Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance. Neurotoxicology. PMID 30036564 DOI: 10.1016/j.neuro.2018.07.012  0.344
2017 Slotkin TA, Skavicus S, Seidler FJ. Diazinon And Parathion Diverge In Their Effects On Development Of Noradrenergic Systems. Brain Research Bulletin. PMID 28235599 DOI: 10.1016/j.brainresbull.2017.02.004  0.398
2016 England LJ, Aagaard K, Bloch M, Conway K, Cosgrove K, Grana R, Gould TJ, Hatsukami D, Jensen F, Kandel D, Lanphear B, Leslie F, Pauly JR, Neiderhiser J, Rubinstein M, ... Slotkin TA, et al. Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products. Neuroscience and Biobehavioral Reviews. PMID 27890689 DOI: 10.1016/J.Neubiorev.2016.11.013  0.38
2016 Slotkin TA, Stadler A, Skavicus S, Card J, Ruff J, Levin ED, Seidler FJ. Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure? Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27633979 DOI: 10.1093/toxsci/kfw180  0.374
2016 Slotkin TA, Stadler A, Skavicus S, Seidler FJ. Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine. Brain Research Bulletin. 122: 71-5. PMID 26993795 DOI: 10.1016/j.brainresbull.2016.03.006  0.372
2016 Hall BJ, Cauley M, Burke DA, Kiany A, Slotkin TA, Levin ED. Cognitive and Behavioral Impairments Evoked by Low Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26919958 DOI: 10.1093/Toxsci/Kfw042  0.315
2015 Slotkin TA, Skavicus S, Seidler FJ. Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos. Toxicology. 338: 8-16. PMID 26419632 DOI: 10.1016/j.tox.2015.09.005  0.416
2015 Slotkin TA, Skavicus S, Card J, Stadler A, Levin ED, Seidler FJ. Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 147: 178-89. PMID 26085346 DOI: 10.1093/toxsci/kfv123  0.377
2015 Slotkin TA, Skavicus S, Card J, Levin ED, Seidler FJ. Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. Toxicology. 333: 63-75. PMID 25891525 DOI: 10.1016/j.tox.2015.04.005  0.303
2015 Slotkin TA, Skavicus S, Levin ED, Seidler FJ. Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. Brain Research Bulletin. 111: 84-96. PMID 25592617 DOI: 10.1016/j.brainresbull.2015.01.003  0.455
2015 Slotkin TA, Seidler FJ. Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". Brain Research Bulletin. 110: 54-67. PMID 25510202 DOI: 10.1016/j.brainresbull.2014.12.003  0.446
2014 Slotkin TA, Card J, Seidler FJ. Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. Brain Research Bulletin. 102: 1-8. PMID 24487013 DOI: 10.1016/j.brainresbull.2014.01.004  0.435
2014 Slotkin TA, Card J, Seidler FJ. Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. Brain Research Bulletin. 100: 44-54. PMID 24280657 DOI: 10.1016/j.brainresbull.2013.10.014  0.316
2014 Levin ED, Cauley M, Johnson JE, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicology and Teratology. 41: 35-42. PMID 24177596 DOI: 10.1016/J.Ntt.2013.10.004  0.362
2013 Slotkin TA, Card J, Seidler FJ. Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. Environmental Health Perspectives. 121: 825-31. PMID 23603068 DOI: 10.1289/ehp.1306528  0.353
2013 Slotkin TA, Card J, Infante A, Seidler FJ. Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor. Neurotoxicology and Teratology. 37: 1-12. PMID 23416428 DOI: 10.1016/j.ntt.2013.02.002  0.415
2012 Slotkin TA, Card J, Seidler FJ. Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. Neurotoxicology and Teratology. 34: 505-12. PMID 22796634 DOI: 10.1016/j.ntt.2012.07.002  0.334
2012 Levin E, Cauley M, Johnson J, Sexton H, Gordon K, Seidler F, Slotkin T. Does pharmacotherapy of preterm labor sensitize the brain to neurotoxicants? Sequential exposure to dexamethasone and chlorpyrifos Neurotoxicology and Teratology. 34: 368. DOI: 10.1016/J.Ntt.2012.05.002  0.402
2011 Slotkin TA, Seidler FJ. Mimicking maternal smoking and pharmacotherapy of preterm labor: fetal nicotine exposure enhances the effect of late gestational dexamethasone treatment on noradrenergic circuits. Brain Research Bulletin. 86: 435-40. PMID 21875656 DOI: 10.1016/j.brainresbull.2011.08.009  0.437
2011 Seidler FJ, Slotkin TA. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids. Brain Research Bulletin. 85: 225-30. PMID 21453761 DOI: 10.1016/j.brainresbull.2011.03.021  0.395
2011 Slotkin TA, Seidler FJ, Spindel ER. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. Neurotoxicology and Teratology. 33: 431-4. PMID 21320590 DOI: 10.1016/j.ntt.2011.02.001  0.387
2010 Adigun AA, Ryde IT, Seidler FJ, Slotkin TA. Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. Brain Research. 1329: 36-44. PMID 20298678 DOI: 10.1016/J.Brainres.2010.03.025  0.812
2010 Slotkin TA, Seidler FJ. Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood. Brain Research Bulletin. 82: 124-34. PMID 20211707 DOI: 10.1016/j.brainresbull.2010.02.015  0.351
2010 Adigun AA, Wrench N, Seidler FJ, Slotkin TA. Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. Environmental Health Perspectives. 118: 210-5. PMID 20123610 DOI: 10.1289/Ehp.0901237  0.793
2010 Adigun AA, Wrench N, Levin ED, Seidler FJ, Slotkin TA. Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum. Brain Research Bulletin. 81: 605-12. PMID 20074626 DOI: 10.1016/J.Brainresbull.2010.01.003  0.808
2010 Adigun AA, Seidler FJ, Slotkin TA. Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. Brain Research. 1316: 1-16. PMID 20026089 DOI: 10.1016/J.Brainres.2009.12.025  0.789
2010 Levin ED, Timofeeva OA, Yang L, Petro A, Ryde IT, Wrench N, Seidler FJ, Slotkin TA. Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behavioural Brain Research. 208: 319-27. PMID 20015457 DOI: 10.1016/j.bbr.2009.11.007  0.385
2010 Slotkin TA, Ryde IT, Seidler FJ. Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery. Brain Research Bulletin. 81: 552-60. PMID 19913076 DOI: 10.1016/j.brainresbull.2009.11.003  0.443
2010 Adigun AA, Wrench N, Seidler FJ, Slotkin TA. Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood. Neurotoxicology and Teratology. 32: 193-9. PMID 19853034 DOI: 10.1016/J.Ntt.2009.10.002  0.8
2009 Billauer-Haimovitch H, Slotkin TA, Dotan S, Langford R, Pinkas A, Yanai J. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation. Behavioural Brain Research. 205: 499-504. PMID 19682500 DOI: 10.1016/j.bbr.2009.08.006  0.318
2009 Yanai J, Pinkas A, Seidler FJ, Ryde IT, Van der Zee EA, Slotkin TA. Neurobehavioral teratogenicity of sarin in an avian model. Neurotoxicology and Teratology. 31: 406-12. PMID 19660543 DOI: 10.1016/j.ntt.2009.07.007  0.324
2009 Slotkin TA, Wrench N, Ryde IT, Lassiter TL, Levin ED, Seidler FJ. Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Neurotoxicology and Teratology. 31: 390-9. PMID 19616088 DOI: 10.1016/j.ntt.2009.07.003  0.325
2009 Slotkin TA, Lassiter TL, Ryde IT, Wrench N, Levin ED, Seidler FJ. Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. Environmental Health Perspectives. 117: 916-22. PMID 19590683 DOI: 10.1289/ehp.0800459  0.351
2009 Slotkin TA, Seidler FJ. Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood. Developmental Neuroscience. 31: 58-70. PMID 19372687 DOI: 10.1159/000207494  0.374
2009 Slotkin TA, Seidler FJ. Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Research. 1263: 23-32. PMID 19368821 DOI: 10.1016/j.brainres.2009.01.049  0.325
2009 Timofeeva O, Yang L, Seidler F, Slotkin T, Levin E. Late-emerging cognitive impairment in male rats after neonatal parathion exposure Neurotoxicology and Teratology. 31: 242. DOI: 10.1016/J.Ntt.2009.04.027  0.362
2008 Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ. Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Environmental Health Perspectives. 116: 1308-14. PMID 18941570 DOI: 10.1289/ehp.11451  0.405
2008 Timofeeva OA, Sanders D, Seemann K, Yang L, Hermanson D, Regenbogen S, Agoos S, Kallepalli A, Rastogi A, Braddy D, Wells C, Perraut C, Seidler FJ, Slotkin TA, Levin ED. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Research Bulletin. 77: 404-11. PMID 18817854 DOI: 10.1016/j.brainresbull.2008.08.019  0.422
2008 Slotkin TA, Ryde IT, Mackillop EA, Bodwell BE, Seidler FJ. Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects. Brain Research Bulletin. 76: 522-30. PMID 18534261 DOI: 10.1016/j.brainresbull.2008.03.001  0.451
2008 Slotkin TA, Seidler FJ, Ryde IT, Yanai J. Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. Neurotoxicology and Teratology. 30: 433-9. PMID 18436430 DOI: 10.1016/j.ntt.2008.02.005  0.37
2008 Slotkin TA, Bodwell BE, Ryde IT, Seidler FJ. Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood. Brain Research Bulletin. 76: 152-65. PMID 18395624 DOI: 10.1016/j.brainresbull.2007.12.009  0.41
2008 Slotkin TA. If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents? Neurotoxicology and Teratology. 30: 1-19. PMID 18380035 DOI: 10.1016/j.ntt.2007.09.002  0.382
2008 Slotkin TA, Ryde IT, Levin ED, Seidler FJ. Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Brain Research Bulletin. 75: 640-7. PMID 18355640 DOI: 10.1016/j.brainresbull.2007.10.008  0.304
2008 Slotkin TA, Bodwell BE, Levin ED, Seidler FJ. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environmental Health Perspectives. 116: 340-8. PMID 18335101 DOI: 10.1289/ehp.11005  0.434
2008 Timofeeva OA, Roegge CS, Seidler FJ, Slotkin TA, Levin ED. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicology and Teratology. 30: 38-45. PMID 18096363 DOI: 10.1016/J.Ntt.2007.10.002  0.314
2008 Levin E, Timofeeva O, Seidler F, Slotkin T. Long-term cognitive effects of low-level developmental organophosphate pesticide exposure: Divergent effects of chlorpyrifos, diazinon and parathion Neurotoxicology and Teratology. 30: 251. DOI: 10.1016/J.Ntt.2008.03.031  0.354
2007 Slotkin TA, Ryde IT, Seidler FJ. Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions. Brain Research Bulletin. 74: 91-103. PMID 17683794 DOI: 10.1016/j.brainresbull.2007.05.007  0.436
2007 Slotkin TA, Seidler FJ. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Research Bulletin. 73: 301-9. PMID 17562396 DOI: 10.1016/j.brainresbull.2007.04.004  0.365
2007 Slotkin TA, Ryde IT, Tate CA, Seidler FJ. Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. Brain Research Bulletin. 73: 259-72. PMID 17562392 DOI: 10.1016/j.brainresbull.2007.03.012  0.483
2007 Slotkin TA, Seidler FJ. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Research Bulletin. 72: 232-74. PMID 17452286 DOI: 10.1016/j.brainresbull.2007.01.005  0.34
2007 Levin ED, Lawrence SS, Petro A, Horton K, Rezvani AH, Seidler FJ, Slotkin TA. Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates. Neurotoxicology and Teratology. 29: 458-65. PMID 17433619 DOI: 10.1016/j.ntt.2007.02.002  0.329
2007 Ginzel KH, Maritz GS, Marks DF, Neuberger M, Pauly JR, Polito JR, Schulte-Hermann R, Slotkin TA. Critical review: nicotine for the fetus, the infant and the adolescent? Journal of Health Psychology. 12: 215-24. PMID 17284486 DOI: 10.1177/1359105307074240  0.306
2007 Slotkin TA, Seidler FJ. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reproductive Toxicology (Elmsford, N.Y.). 23: 421-7. PMID 17267174 DOI: 10.1016/j.reprotox.2006.07.010  0.351
2007 Slotkin TA, MacKillop EA, Rudder CL, Ryde IT, Tate CA, Seidler FJ. Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1082-97. PMID 17047666 DOI: 10.1038/sj.npp.1301231  0.471
2007 Slotkin TA, Seidler FJ. A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. Neurotoxicology and Teratology. 29: 10-6. PMID 16919421 DOI: 10.1016/j.ntt.2006.06.001  0.364
2006 Levin ED, Lawrence S, Petro A, Horton K, Seidler FJ, Slotkin TA. Increased nicotine self-administration following prenatal exposure in female rats. Pharmacology, Biochemistry, and Behavior. 85: 669-74. PMID 17196243 DOI: 10.1016/j.pbb.2006.11.006  0.351
2006 Slotkin TA, Levin ED, Seidler FJ. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environmental Health Perspectives. 114: 746-51. PMID 16675431 DOI: 10.1289/ehp.8828  0.311
2006 Slotkin TA, Seidler FJ. Anomalous regulation of β-adrenoceptor signaling in brain regions of the newborn rat Brain Research. 1077: 54-58. PMID 16487945 DOI: 10.1016/j.brainres.2006.01.047  0.303
2006 Slotkin TA, Pinkerton KE, Seidler FJ. Perinatal environmental tobacco smoke exposure in rhesus monkeys: Critical periods and regional selectivity for effects on brain cell development and lipid peroxidation Environmental Health Perspectives. 114: 34-39. PMID 16393655 DOI: 10.1289/ehp.8286  0.356
2006 Jacobsen LK, Slotkin TA, Westerveld M, Mencl WE, Pugh KR. Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smoking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1550-61. PMID 16341023 DOI: 10.1038/Sj.Npp.1300981  0.319
2006 Slotkin TA, Tate CA, Cousins MM, Seidler FJ. Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2462-75. PMID 16341021 DOI: 10.1038/sj.npp.1300988  0.422
2006 Slotkin TA, Kreider ML, Tate CA, Seidler FJ. Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 904-11. PMID 16160705 DOI: 10.1038/sj.npp.1300892  0.304
2006 Kreider ML, Tate CA, Cousins MM, Oliver CA, Seidler FJ, Slotkin TA. Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 12-35. PMID 15920497 DOI: 10.1038/sj.npp.1300783  0.365
2005 Garcia SJ, Seidler FJ, Slotkin TA. Developmental neurotoxicity of chlorpyrifos: targeting glial cells. Environmental Toxicology and Pharmacology. 19: 455-61. PMID 21783512 DOI: 10.1016/J.Etap.2004.12.007  0.68
2005 Slikker W, Xu ZA, Levin ED, Slotkin TA. Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine. Critical Reviews in Toxicology. 35: 703-11. PMID 16417037 DOI: 10.1080/10408440591007421  0.422
2005 Slotkin TA, Tate CA, Cousins MM, Seidler FJ. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Brain Research. Developmental Brain Research. 160: 219-30. PMID 16256208 DOI: 10.1016/j.devbrainres.2005.09.006  0.411
2005 Slotkin TA, Brown KK, Seidler FJ. Developmental exposures of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood Environmental Health Perspectives. 113: 1291-1294. PMID 16203236 DOI: 10.1289/ehp.8133  0.347
2005 Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environmental Health Perspectives. 113: 1027-31. PMID 16079074 DOI: 10.1289/Ehp.7968  0.769
2005 Slotkin TA, Seidler FJ. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent Developmental Brain Research. 158: 115-119. PMID 16024092 DOI: 10.1016/j.devbrainres.2005.06.008  0.34
2005 Slotkin TA, Oliver CA, Seidler FJ. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Brain Research. Developmental Brain Research. 157: 172-80. PMID 15963356 DOI: 10.1016/j.devbrainres.2005.04.001  0.36
2005 Qiao D, Seidler FJ, Slotkin TA. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos Toxicology and Applied Pharmacology. 206: 17-26. PMID 15963341 DOI: 10.1016/j.taap.2004.11.003  0.389
2005 Aldridge JE, Levin ED, Seidler FJ, Slotkin TA. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environmental Health Perspectives. 113: 527-31. PMID 15866758 DOI: 10.1289/Ehp.7867  0.755
2005 Kreider ML, Aldridge JE, Cousins MM, Oliver CA, Seidler FJ, Slotkin TA. Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1841-55. PMID 15841102 DOI: 10.1038/Sj.Npp.1300743  0.785
2005 Meyer A, Seidler FJ, Aldridge JE, Slotkin TA. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicology and Applied Pharmacology. 203: 154-66. PMID 15710176 DOI: 10.1016/J.Taap.2004.08.005  0.802
2005 Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicology and Applied Pharmacology. 203: 132-44. PMID 15710174 DOI: 10.1016/J.Taap.2004.08.002  0.762
2005 Abreu-Villaça Y, Seidler FJ, Qiao D, Slotkin TA. Modeling the developmental neurotoxicity of nicotine in vitro: Cell acquisition, growth and viability in PC12 cells Developmental Brain Research. 154: 239-246. PMID 15707677 DOI: 10.1016/j.devbrainres.2004.10.018  0.347
2005 Beer A, Slotkin TA, Seidler FJ, Aldridge JE, Yanai J. Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 156-65. PMID 15496940 DOI: 10.1038/Sj.Npp.1300582  0.783
2005 Slotkin TA, Seidler FJ, Qiao D, Aldridge JE, Tate CA, Cousins MM, Proskocil BJ, Sekhon HS, Clark JA, Lupo SL, Spindel ER. Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 129-44. PMID 15316571 DOI: 10.1038/Sj.Npp.1300544  0.785
2004 Slotkin TA, Cousins MM, Seidler FJ. Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS α7 nicotinic acetylcholine receptors Brain Research. 1030: 159-163. PMID 15567348 DOI: 10.1016/j.brainres.2004.10.009  0.375
2004 Yanai J, Beer A, Huleihel R, Izrael M, Katz S, Levi Y, Rozenboim I, Yaniv SP, Slotkin TA. Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models. Annals of the New York Academy of Sciences. 1025: 595-601. PMID 15542768 DOI: 10.1196/annals.1316.074  0.33
2004 Izrael M, Van der Zee EA, Slotkin TA, Yanai J. Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. Journal of Neuroscience Research. 78: 499-507. PMID 15470723 DOI: 10.1002/jnr.20287  0.31
2004 Slotkin TA, Southard MC, Adam SJ, Cousins MM, Seidler FJ. α7 Nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: Nicotine and chlorpyrifos Brain Research Bulletin. 64: 227-235. PMID 15464859 DOI: 10.1016/j.brainresbull.2004.07.005  0.371
2004 Slotkin TA. Cholinergic systems in brain development and disruption by neurotoxicants: Nicotine, environmental tobacco smoke, organophosphates Toxicology and Applied Pharmacology. 198: 132-151. PMID 15236950 DOI: 10.1016/j.taap.2003.06.001  0.409
2004 Abreu-Villaça Y, Seidler FJ, Slotkin TA. Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence? Neuropsychopharmacology. 29: 1440-1450. PMID 15039772 DOI: 10.1038/sj.npp.1300443  0.405
2004 Icenogle LM, Christopher NC, Blackwelder WP, Caldwell DP, Qiao D, Seidler FJ, Slotkin TA, Levin ED. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicology and Teratology. 26: 95-101. PMID 15001218 DOI: 10.1016/j.ntt.2003.09.001  0.352
2004 Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA. Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environmental Health Perspectives. 112: 295-301. PMID 14998743 DOI: 10.1289/Ehp.6755  0.805
2004 Rhodes MC, Seidler FJ, Qiao D, Tate CA, Cousins MM, Slotkin TA. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicology and Applied Pharmacology. 195: 203-17. PMID 14998686 DOI: 10.1016/j.taap.2003.11.008  0.452
2004 Abreu-Villaça Y, Seidler FJ, Tate CA, Cousins MM, Slotkin TA. Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 879-90. PMID 14970833 DOI: 10.1038/sj.npp.1300401  0.406
2004 Roy TS, Seidler FJ, Slotkin TA. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: Regionally selective alterations in neurons and glia Developmental Brain Research. 148: 197-206. PMID 14766197 DOI: 10.1016/j.devbrainres.2003.12.004  0.32
2004 Qiao D, Seidler FJ, Abreu-Villaça Y, Tate CA, Cousins MM, Slotkin TA. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Brain Research. Developmental Brain Research. 148: 43-52. PMID 14757517 DOI: 10.1016/j.devbrainres.2003.10.004  0.416
2004 Meyer A, Seidler FJ, Slotkin TA. Developmental effects of chlorpyrifos extend beyond neurotoxicity: Critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling Environmental Health Perspectives. 112: 170-178. PMID 14754571  0.429
2004 Aldridge JE, Seidler FJ, Slotkin TA. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environmental Health Perspectives. 112: 148-55. PMID 14754568 DOI: 10.1289/Ehp.6713  0.76
2004 Rhodes MC, Seidler FJ, Abdel-Rahman A, Tate CA, Nyska A, Rincavage HL, Slotkin TA. Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex. The Journal of Pharmacology and Experimental Therapeutics. 308: 529-37. PMID 14610225 DOI: 10.1124/jpet.103.060095  0.356
2003 Qiao D, Seidler FJ, Violin JD, Slotkin TA. Nicotine is a developmental neurotoxicant and neuroprotectant: Stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos Developmental Brain Research. 147: 183-190. PMID 14741763 DOI: 10.1016/S0165-3806(03)00222-0  0.354
2003 Xu Z, Seidler FJ, Tate CA, Garcia SJ, Slikker W, Slotkin TA. Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteins. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 5: 955-60. PMID 14668080 DOI: 10.1080/14622200310001615321  0.685
2003 Navarro HA, Basta PV, Seidler FJ, Slotkin TA. Short-term adolescent nicotine exposure in rats elicits immediate and delayed deficits in T-lymphocyte function: Critical periods, patterns of exposure, dose thresholds Nicotine and Tobacco Research. 5: 859-868. PMID 14668069 DOI: 10.1080/14622200310001614610  0.391
2003 Meyer A, Seidler FJ, Cousins MM, Slotkin TA. Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: When is adenylyl cyclase a target? Environmental Health Perspectives. 111: 1871-1876. PMID 14644659 DOI: 10.1289/EHP.6468  0.37
2003 Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environmental Health Perspectives. 111: 1736-43. PMID 14594624 DOI: 10.1289/Ehp.6489  0.761
2003 Abreu-Villaça Y, Seidler FJ, Slotkin TA. Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: Enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal Brain Research. 988: 164-172. PMID 14519538 DOI: 10.1016/S0006-8993(03)03368-7  0.453
2003 Slotkin TA, Seidler FJ, Yanai J. Heroin neuroteratogenicity: Delayed-onset deficits in catecholaminergic synaptic activity Brain Research. 984: 189-197. PMID 12932853 DOI: 10.1016/S0006-8993(03)03152-4  0.314
2003 Slotkin TA, Freibaum BD, Tate CA, Thillai I, Ferguson SA, Cada AM, Seidler FJ. Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. Brain Research. 981: 118-25. PMID 12885432 DOI: 10.1016/S0006-8993(03)02993-7  0.459
2003 Abreu-Villaça Y, Seidler FJ, Tate CA, Slotkin TA. Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations. Brain Research. 979: 114-28. PMID 12850578 DOI: 10.1016/S0006-8993(03)02885-3  0.43
2003 Abreu-Villaça Y, Seidler FJ, Qiao D, Tate CA, Cousins MM, Thillai I, Slotkin TA. Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1935-49. PMID 12784097 DOI: 10.1038/sj.npp.1300221  0.441
2003 Slotkin TA, Auman JT, Seidler FJ. Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs. The Journal of Pharmacology and Experimental Therapeutics. 306: 1-7. PMID 12682213 DOI: 10.1124/jpet.102.048421  0.696
2003 Qiao D, Seidler FJ, Tate CA, Cousins MM, Slotkin TA. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environmental Health Perspectives. 111: 536-44. PMID 12676612 DOI: 10.1289/ehp.5828  0.442
2003 Garcia SJ, Seidler FJ, Slotkin TA. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environmental Health Perspectives. 111: 297-303. PMID 12611658 DOI: 10.1289/Ehp.5791  0.667
2003 Shahak H, Slotkin TA, Yanai J. Alterations in PKCγ in the mouse hippocampus after prenatal exposure to heroin: A link from cell signaling to behavioral outcome Developmental Brain Research. 140: 117-125. PMID 12524182 DOI: 10.1016/S0165-3806(02)00607-7  0.35
2003 Garofolo MC, Seidler FJ, Cousins MM, Tate CA, Qiao D, Slotkin TA. Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver. Brain Research Bulletin. 59: 319-29. PMID 12464406 DOI: 10.1016/S0361-9230(02)00925-5  0.34
2002 Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology and Teratology. 24: 733-41. PMID 12460655 DOI: 10.1016/S0892-0362(02)00272-6  0.372
2002 Qiao D, Seidler FJ, Padilla S, Slotkin TA. Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? Environmental Health Perspectives. 110: 1097-103. PMID 12417480 DOI: 10.1289/ehp.021101097  0.307
2002 Auman JT, Seidler FJ, Slotkin TA. Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 283: R1236-44. PMID 12376418 DOI: 10.1152/Ajpregu.00409.2002  0.651
2002 Xu Z, Seidler FJ, Cousins MM, Slikker W, Slotkin TA. Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. Brain Research. 951: 280-92. PMID 12270507 DOI: 10.1016/S0006-8993(02)03174-8  0.414
2002 Yanai J, Vatury O, Slotkin TA. Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis Annals of the New York Academy of Sciences. 965: 473-478. PMID 12105122  0.316
2002 Auman JT, Seidler FJ, Tate CA, Slotkin TA. Are developing beta-adrenoceptors able to desensitize? Acute and chronic effects of beta-agonists in neonatal heart and liver. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 283: R205-17. PMID 12069947 DOI: 10.1152/ajpregu.00122.2002  0.679
2002 Slotkin TA. Nicotine and the adolescent brain: Insights from an animal model Neurotoxicology and Teratology. 24: 369-384. PMID 12009492 DOI: 10.1016/S0892-0362(02)00199-X  0.421
2002 Garofolo MC, Seidler FJ, Auman JT, Slotkin TA. beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R1356-63. PMID 11959676 DOI: 10.1152/ajpregu.00598.2001  0.678
2002 Slotkin TA, Pinkerton KE, Auman JT, Qiao D, Seidler FJ. Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. Brain Research. Developmental Brain Research. 133: 175-9. PMID 11882347  0.738
2002 Slotkin TA, Tate CA, Cousins MM, Seidler FJ. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Brain Research. Developmental Brain Research. 133: 163-73. PMID 11882346 DOI: 10.1016/S0165-3806(02)00284-5  0.454
2002 Garcia SJ, Seidler FJ, Qiao D, Slotkin TA. Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Brain Research. Developmental Brain Research. 133: 151-61. PMID 11882345 DOI: 10.1016/S0165-3806(02)00283-3  0.653
2002 Roy TS, Seidler FJ, Slotkin TA. Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex Journal of Pharmacology and Experimental Therapeutics. 300: 124-133. PMID 11752107 DOI: 10.1124/jpet.300.1.124  0.394
2001 Slotkin TA, Seidler FJ, Yanai J. Heroin neuroteratogenicity: Targeting adenylyl cyclase as an underlying biochemical mechanism Developmental Brain Research. 132: 69-79. PMID 11744108 DOI: 10.1016/S0165-3806(01)00296-6  0.351
2001 Slotkin TA, Tate CA, Cousins MM, Seidler FJ. Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline. Brain Research. Developmental Brain Research. 131: 113-25. PMID 11718842 DOI: 10.1016/S0165-3806(01)00282-6  0.361
2001 Auman JT, Seidler FJ, Tate CA, Slotkin TA. Beta-adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281: R1895-901. PMID 11705775  0.689
2001 Navarro HA, Basta PV, Seidler FJ, Slotkin TA. Adolescent nicotine: Deficits in immune function Developmental Brain Research. 130: 253-256. PMID 11675127 DOI: 10.1016/S0165-3806(01)00256-5  0.472
2001 Navarro HA, Basta PV, Seidler FJ, Slotkin TA. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: A neural effect? Developmental Brain Research. 130: 249-252. PMID 11675126 DOI: 10.1016/S0165-3806(01)00254-1  0.479
2001 Xu Z, Seidler FJ, Ali SF, Slikker W, Slotkin TA. Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. Brain Research. 914: 166-78. PMID 11578609 DOI: 10.1016/S0006-8993(01)02797-4  0.403
2001 Auman JT, Seidler FJ, Slotkin TA. Regulation of fetal cardiac and hepatic beta-adrenoceptors and adenylyl cyclase signaling: terbutaline effects. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281: R1079-89. PMID 11557613  0.663
2001 Levin ED, Addy N, Nakajima A, Christopher NC, Seidler FJ, Slotkin TA. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Research. Developmental Brain Research. 130: 83-9. PMID 11557096 DOI: 10.1016/S0165-3806(01)00215-2  0.388
2001 Raines KW, Seidler FJ, Slotkin TA. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos Developmental Brain Research. 130: 65-72. PMID 11557094 DOI: 10.1016/S0165-3806(01)00211-5  0.304
2001 Buznikov GA, Nikitina LA, Bezuglov VV, Lauder JM, Padilla S, Slotkin TA. An invertebrate model of the developmental neurotoxicity of insecticides: Effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae Environmental Health Perspectives. 109: 651-661. PMID 11485862 DOI: 10.1289/Ehp.01109651  0.331
2001 Slotkin TA, Cousins MM, Tate CA, Seidler FJ. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Research. 902: 229-43. PMID 11384617 DOI: 10.1016/S0006-8993(01)02387-3  0.426
2001 Slotkin TA, Pinkerton KE, Garofolo MC, Auman JT, McCook EC, Seidler FJ. Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats. Brain Research. 898: 73-81. PMID 11292450 DOI: 10.1016/S0006-8993(01)02145-X  0.736
2001 Trauth JA, Seidler FJ, Ali SF, Slotkin TA. Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. Brain Research. 892: 269-80. PMID 11172774 DOI: 10.1016/S0006-8993(00)03227-3  0.813
2001 Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Research. 891: 54-68. PMID 11164809 DOI: 10.1016/S0006-8993(00)03189-9  0.63
2001 Slotkin TA, Pinkerton KE, Seidler FJ. Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung. Brain Research. Developmental Brain Research. 124: 53-8. PMID 11113511 DOI: 10.1016/S0165-3806(00)00105-X  0.355
2000 Slotkin TA, Ferguson SA, Cada AM, McCook EC, Seidler FJ. Neonatal polyamine depletion by α-difluoromethylornithine: Effects on adenylyl cyclase cell signaling are separable from effects on brain region growth Brain Research. 887: 16-22. PMID 11134585 DOI: 10.1016/S0006-8993(00)02961-9  0.372
2000 Trauth JA, Seidler FJ, Slotkin TA. Persistent and delayed behavioral changes after nicotine treatment in adolescent rats. Brain Research. 880: 167-72. PMID 11033001 DOI: 10.1016/S0006-8993(00)02823-7  0.814
2000 Chow FA, Seidler FJ, McCook EC, Slotkin TA. Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase. Brain Research. 878: 119-26. PMID 10996142 DOI: 10.1016/S0006-8993(00)02697-4  0.432
2000 Steingart RA, Abu-Roumi M, Newman ME, Silverman WF, Slotkin TA, Yanai J. Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts. Brain Research. Developmental Brain Research. 122: 125-33. PMID 10960681 DOI: 10.1016/S0165-3806(00)00063-8  0.334
2000 Trauth JA, McCook EC, Seidler FJ, Slotkin TA. Modeling adolescent nicotine exposure: effects on cholinergic systems in rat brain regions. Brain Research. 873: 18-25. PMID 10915806 DOI: 10.1016/S0006-8993(00)02465-3  0.812
2000 Dam K, Seidler FJ, Slotkin TA. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Research. Developmental Brain Research. 121: 179-87. PMID 10876030 DOI: 10.1016/S0165-3806(00)00044-4  0.36
2000 Slotkin TA, Zhang J, Dancel R, Garcia SJ, Willis C, Seidler FJ. Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. Breast Cancer Research and Treatment. 60: 153-66. PMID 10845278 DOI: 10.1023/A:1006338232150  0.614
2000 Auman JT, Seidler FJ, Slotkin TA. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Brain Research. Developmental Brain Research. 121: 19-27. PMID 10837889 DOI: 10.1016/S0165-3806(00)00021-3  0.722
2000 Trauth JA, Seidler FJ, Slotkin TA. An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions. Brain Research. 867: 29-39. PMID 10837795 DOI: 10.1016/S0006-8993(00)02208-3  0.817
1999 Trauth JA, Seidler FJ, McCook EC, Slotkin TA. Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions. Brain Research. 851: 9-19. PMID 10642823 DOI: 10.1016/S0006-8993(99)01994-0  0.821
1999 Dam K, Garcia SJ, Seidler FJ, Slotkin TA. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Brain Research. Developmental Brain Research. 116: 9-20. PMID 10446342 DOI: 10.1016/S0165-3806(99)00067-X  0.651
1999 Slotkin TA. Developmental cholinotoxicants: Nicotine and chlorpyrifos Environmental Health Perspectives. 107: 71-80. PMID 10229709 DOI: 10.1289/ehp.99107s171  0.385
1999 Slotkin TA, Epps TA, Stenger ML, Sawyer KJ, Seidler FJ. Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. Brain Research. Developmental Brain Research. 113: 1-12. PMID 10064868 DOI: 10.1016/s0165-3806(98)00173-4  0.402
1999 Trauth JA, Seidler FJ, McCook EC, Slotkin TA. Persistent c-fos induction by nicotine in developing rat brain regions: interaction with hypoxia. Pediatric Research. 45: 38-45. PMID 9890606 DOI: 10.1203/00006450-199901000-00007  0.814
1998 Roy TS, Andrews JE, Seidler FJ, Slotkin TA. Nicotine evokes cell death in embryonic rat brain during neurulation Journal of Pharmacology and Experimental Therapeutics. 287: 1136-1144. PMID 9864303  0.409
1998 Song X, Violin JD, Seidler FJ, Slotkin TA. Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. Toxicology and Applied Pharmacology. 151: 182-91. PMID 9705902 DOI: 10.1006/taap.1998.8424  0.327
1998 Dam K, Seidler FJ, Slotkin TA. Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration. Brain Research. Developmental Brain Research. 108: 39-45. PMID 9693782 DOI: 10.1016/S0165-3806(98)00028-5  0.339
1998 Slotkin TA. Fetal nicotine or cocaine exposure: Which one is worse? Journal of Pharmacology and Experimental Therapeutics. 285: 931-945. PMID 9618392  0.369
1998 Johnson DE, Seidler FJ, Slotkin TA. Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos. Brain Research Bulletin. 45: 143-7. PMID 9443830 DOI: 10.1016/S0361-9230(97)00329-8  0.345
1997 Campbell CG, Seidler FJ, Slotkin TA. Chlorpyrifos interferes with cell development in rat brain regions. Brain Research Bulletin. 43: 179-89. PMID 9222531 DOI: 10.1016/S0361-9230(96)00436-4  0.33
1997 Song X, Seidler FJ, Saleh JL, Zhang J, Padilla S, Slotkin TA. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicology and Applied Pharmacology. 145: 158-74. PMID 9221834 DOI: 10.1006/taap.1997.8171  0.405
1997 Slotkin TA, Saleh JL, McCook EC, Seidler FJ. Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome. Teratology. 55: 177-84. PMID 9181671 DOI: 10.1002/(SICI)1096-9926(199703)55:3<177::AID-TERA2>3.0.CO;2  0.352
1997 Zeiders JL, Seidler FJ, Slotkin TA. Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. Journal of Molecular and Cellular Cardiology. 29: 603-15. PMID 9140819 DOI: 10.1006/jmcc.1996.0303  0.332
1997 Slotkin TA. Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression Brain Research. 750: 180-188. PMID 9098543 DOI: 10.1016/S0006-8993(96)01345-5  0.415
1996 Slotkin TA, Saleh JL, Zhang J, Seidler FJ. Ontogeny of beta-adrenoceptor/adenylyl cyclase desensitization mechanisms: the role of neonatal innervation. Brain Research. 742: 317-28. PMID 9117411 DOI: 10.1016/S0006-8993(96)00978-X  0.328
1996 Giannuzzi CE, Seidler FJ, Slotkin TA. Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization. Brain Research. 694: 271-8. PMID 8974654 DOI: 10.1016/0006-8993(95)00781-K  0.324
1996 Tolson CM, Seidler FJ, McCook EC, Slotkin TA. Does concurrent or prior nicotine exposure interact with neonatal hypoxia to produce cardiac cell damage? Teratology. 52: 298-305. PMID 8838253 DOI: 10.1002/tera.1420520508  0.415
1995 Schachat F, Seidler FJ, Slotkin TA. The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic amp Reproduction, Fertility and Development. 7: 1361-1367. PMID 8848612 DOI: 10.1071/Rd9951361  0.3
1995 Slotkin TA, Lappi SE, McCook EC, Lorber BA, Seidler FJ. Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: Implications for sudden infant death syndrome Brain Research Bulletin. 38: 69-75. PMID 7552377 DOI: 10.1016/0361-9230(95)00073-N  0.352
1995 Whitney KD, Seidler FJ, Slotkin TA. Developmental neurotoxicity of chlorpyrifos: cellular mechanisms. Toxicology and Applied Pharmacology. 134: 53-62. PMID 7545834 DOI: 10.1006/taap.1995.1168  0.339
1994 Slotkin TA, Lau C, Mccook EC, Lappi SE, Seidler FJ. Glucocorticoids Enhance Intracellular Signaling via Adenylate Cyclase at Three Distinct Loci in the Fetus: A Mechanism for Heterologous Teratogenic Sensitization? Toxicology and Applied Pharmacology. 127: 64-75. PMID 8048055 DOI: 10.1006/taap.1994.1140  0.336
1994 Seidler FJ, Albright ES, Lappi SE, Slotkin TA. In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions Developmental Brain Research. 82: 1-8. PMID 7842497 DOI: 10.1016/0165-3806(94)90142-2  0.414
1993 Zahalka EA, Seidler FJ, Yanai J, Slotkin TA. Fetal nicotine exposure alters ontogeny of M1-receptors and their link to G-proteins. Neurotoxicology and Teratology. 15: 107-15. PMID 8510605 DOI: 10.1016/0892-0362(93)90069-Z  0.415
1993 Slotkin TA, Lappi SE, Seidler FJ. Impact of fetal nicotine exposure on development of rat brain regions: Critical sensitive periods or effects of withdrawal? Brain Research Bulletin. 31: 319-328. PMID 8490731 DOI: 10.1016/0361-9230(93)90224-Y  0.45
1993 Yanai J, Rogel-Fuchs Y, Pick CG, Slotkin T, Seidler FJ, Zahalka EA, Newman ME. Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. Neuropharmacology. 32: 113-7. PMID 8450940 DOI: 10.1016/0028-3908(93)90090-P  0.35
1993 Seidler FJ, Slotkin TA. Prenatal cocaine and cell development in rat brain regions: Effects on ornithine decarboxylase and macromolecules Brain Research Bulletin. 30: 91-99. PMID 8420640 DOI: 10.1016/0361-9230(93)90043-B  0.305
1993 Slotkin TA, McCook EC, Seidler FJ. Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure. Brain Research Bulletin. 32: 359-64. PMID 8221125 DOI: 10.1016/0361-9230(93)90200-U  0.341
1993 Bian X, Seidler FJ, Olsen C, Raymond JR, Slotkin TA. Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein. Teratology. 48: 169-77. PMID 8211822 DOI: 10.1002/tera.1420480211  0.317
1992 Carlos RQ, Seidler FJ, Slotkin TA. Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis. Brain Research. Developmental Brain Research. 64: 161-6. PMID 1786639 DOI: 10.1016/0165-3806(91)90220-D  0.311
1992 Slotkin TA, Seidler FJ. Transient postnatal elevation of norepinephrine content and turnover in brain regions of rats exposed to terbutaline prenatally: Evidence for autoregulation of noradrenergic development? Research Communications in Chemical Pathology and Pharmacology. 76: 269-278. PMID 1636051  0.325
1992 Zahalka EA, Seidler FJ, Lappi SE, Mccook EC, Yanai J, Slotkin TA. Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: Differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding Neurotoxicology and Teratology. 14: 375-382. PMID 1488031 DOI: 10.1016/0892-0362(92)90047-E  0.416
1992 Seidler FJ, Levin ED, Lappi SE, Slotkin TA. Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions. Brain Research. Developmental Brain Research. 69: 288-91. PMID 1424104 DOI: 10.1016/0165-3806(92)90170-2  0.426
1992 Slotkin TA, McCook EC, Lappi SE, Seidler FJ. Altered development of basal and forskolin-stimulated adenylate cyclase activity in brain regions of rats exposed to nicotine prenatally Developmental Brain Research. 68: 233-239. PMID 1394969 DOI: 10.1016/0165-3806(92)90065-5  0.435
1992 Slotkin TA, Lappi SE, McCook EC, Tayyeb MI, Eylers JP, Seidlcr FJ. Glucocorticoids and the development of neuronal function: Effects of prenatal dexamethasone exposure on central noradrenergic activity Neonatology. 61: 326-336. PMID 1391259 DOI: 10.1159/000243761  0.367
1992 Seidler FJ, Slotkin TA. Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: Effects on neurotransmitter turnover and receptors Journal of Pharmacology and Experimental Therapeutics. 263: 413-421. PMID 1331397  0.3
1991 Slotkin TA, Navarro HA, McCook EC, Seidler FJ. Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. Life Sciences. 47: 1561-7. PMID 2174490 DOI: 10.1016/0024-3205(90)90185-T  0.529
1991 Carlos RQ, Seidler FJ, Lappi SE, Slotkin TA. Fetal dexamethasone exposure affects basal ornithine decarboxylase activity in developing rat brain regions and alters acute responses to hypoxia and maternal separation Neonatology. 59: 69-77. PMID 2036470 DOI: 10.1159/000243325  0.365
1991 McFarland BJ, Seidler FJ, Slotkin TA. Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration Developmental Brain Research. 58: 223-229. PMID 2029766 DOI: 10.1016/0165-3806(91)90008-7  0.392
1991 Slotkin TA, Lappi SE, Tayyeb MI, Seidler FJ. Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase Life Sciences. 49: 665-670. PMID 1865760 DOI: 10.1016/0024-3205(91)90113-P  0.425
1991 Smith IV WT, Seidler FJ, Slotkin TA. Acute stimulation of ornithine decarboxylase in neonatal rat brain regions by nicotine: a central receptor-mediated process? Developmental Brain Research. 63: 85-93. PMID 1790600 DOI: 10.1016/0165-3806(91)90069-U  0.425
1991 Navarro HA, Kudlacz EM, Kavlock RJ, Slotkin TA. Prenatal terbutaline treatment: tissue-selective dissociation of perinatal changes in beta-adrenergic receptor binding from regulation of adenylate cyclase activity. Life Sciences. 48: 269-74. PMID 1671519 DOI: 10.1016/0024-3205(91)90354-E  0.388
1991 Wagner JP, Seidler FJ, Slotkin TA. Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol. Brain Research Bulletin. 26: 885-90. PMID 1657319 DOI: 10.1016/0361-9230(91)90253-G  0.347
1991 Navarro HA, Kudlacz EM, Slotkin TA. Control of adenylate cyclase activity in developing rat heart and liver: effects of prenatal exposure to terbutaline or dexamethasone. Biology of the Neonate. 60: 127-36. PMID 1657219 DOI: 10.1159/000243398  0.305
1990 Navarro HA, Mills E, Seidler FJ, Baker FE, Lappi SE, Tayyeb MI, Spencer JR, Slotkin TA. Prenatal nicotine exposure impairs β-adrenergic function: Persistent chronotropic subsensitivity despite recovery from deficits in receptor binding Brain Research Bulletin. 25: 233-237. PMID 2171720 DOI: 10.1016/0361-9230(90)90066-9  0.481
1990 Seidler FJ, Slotkin TA. Effects of acute hypoxia on neonatal rat brain: Regionally selective, long-term alterations in catecholamine levels and turnover Brain Research Bulletin. 24: 157-161. PMID 2157528 DOI: 10.1016/0361-9230(90)90200-J  0.32
1990 Seidler FJ, Bell JM, Slotkin TA. Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions. Pediatric Research. 27: 191-7. PMID 2156213 DOI: 10.1203/00006450-199002000-00021  0.323
1989 Navarro HA, Seidler FJ, Schwartz RD, Baker FE, Dobbins SS, Slotkin TA. Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth. Brain Research Bulletin. 23: 187-92. PMID 2819477 DOI: 10.1016/0361-9230(89)90146-9  0.379
1989 Slotkin TA, Baker FE, Dobbins SS, Eylers JP, Lappi SE, Seidler FJ. Prenatal terbutaline exposure in the rat: Selective effects on development of noradrenergic projections to cerebellum Brain Research Bulletin. 23: 263-265. PMID 2590837 DOI: 10.1016/0361-9230(89)90206-2  0.363
1989 Kudlacz EM, Navarro HA, Eylers JP, Lappi SE, Dobbins SS, Slotkin TA. Effects of prenatal terbutaline exposure on cellular development in lung and liver of neonatal rat: Ornithine decarboxylase activity and macromolecules Pediatric Research. 25: 617-622. PMID 2472593 DOI: 10.1203/00006450-198906000-00013  0.406
1988 Bell JM, Whitmore WL, Barnes G, Seidler FJ, Slotkin TA. Perinatal dietary exposure to soy lecithin: altered sensitivity to central cholinergic stimulation. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 4: 497-501. PMID 3455608 DOI: 10.1016/0736-5748(86)90001-8  0.419
1987 Slotkin TA, Orband-Miller L, Queen KL. Development of [3H]nicotine binding sites in brain regions of rats exposed to nicotine prenatally via maternal injections or infusions Journal of Pharmacology and Experimental Therapeutics. 242: 232-237. PMID 3612529  0.411
1987 Slotkin TA, Cho H, Whitmore WL. Effects of prenatal nicotine exposure on neuronal development: Selective actions on central and peripheral catecholaminergic pathways Brain Research Bulletin. 18: 601-611. PMID 3607529 DOI: 10.1016/0361-9230(87)90130-4  0.427
1987 Slotkin TA, Bartolome J. Biochemical mechanisms of developmental neurotoxicity of methylmercury Neurotoxicology. 8: 65-84. PMID 2882450  0.352
1986 Slotkin TA, Greer N, Faust J, Cho H, Seidler FJ. Effects of maternal nicotine injections on brain development in the rat: ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions. Brain Research Bulletin. 17: 41-50. PMID 3756543 DOI: 10.1016/0361-9230(86)90159-0  0.367
1986 Bell JM, Whitmore WL, Cowdery T, Slotkin TA. Perinatal dietary supplementation with a soy lecithin preparation: Effects on development of central catecholaminergic neurotransmitter systems Brain Research Bulletin. 17: 189-195. PMID 2876756 DOI: 10.1016/0361-9230(86)90115-2  0.335
1985 Slotkin TA, Pachman S, Kavlock RJ, Bartolome J. Early biochemical detection of adverse effects of a neurobehavioral teratogen: influence of prenatal methylmercury exposure on ornithine decarboxylase in brain and other tissues of fetal and neonatal rat. Teratology. 32: 195-202. PMID 4049277 DOI: 10.1002/tera.1420320207  0.304
1985 Bartolome J, Grignolo A, Bartolome M, Trepanier P, Lerea L, Weigel S, Whitmore W, Michalopoulos G, Kavlock R, Slotkin T. Postnatal methyl mercury exposure: effects on ontogeny of renal and hepatic ornithine decarboxylase responses to trophic stimuli. Toxicology and Applied Pharmacology. 80: 147-54. PMID 4024102 DOI: 10.1016/0041-008X(85)90109-7  0.354
1985 Morris G, Nadler JV, Nemeroff CB, Slotkin TA. Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity in cerebellum of the development rat. Biochemical Pharmacology. 34: 3281-4. PMID 2931085 DOI: 10.1016/0006-2952(85)90346-6  0.355
1985 Morris G, Slotkin TA. Beta-2 adrenergic control of ornithine decarboxylase activity in brain regions of the developing rat Journal of Pharmacology and Experimental Therapeutics. 233: 141-147. PMID 2858576  0.363
1985 Bell JM, Slotkin TA. Perinatal dietary supplementation with a commercial soy lecithin preparation: Effects on behavior and brain biochemistry in the developing rat Developmental Psychobiology. 18: 383-394. PMID 2415412  0.346
1985 Slotkin TA, Pachman S, Kavlock RJ, Bartolome J. Effects of neonatal methylmercury exposure on development of nucleic acids and proteins in rat brain: regional specificity. Brain Research Bulletin. 14: 397-400. PMID 2411358 DOI: 10.1016/0361-9230(85)90015-2  0.301
1984 Bartolome J, Whitmore WL, Seidler FJ, Slotkin TA. Exposure to methylmercury in utero: effects on biochemical development of catecholamine neurotransmitter systems. Life Sciences. 35: 657-70. PMID 6146912 DOI: 10.1016/0024-3205(84)90261-3  0.337
1983 Slotkin TA, Seidler FJ, Whitmore WL, Weigel SJ, Slepetis RJ, Lerea L, Trepanier PA, Bartolome J. Critical periods for the role of ornithine decarboxylase and the polyamines in growth and development of the rat: Effects of exposure to α-difluoromethylornithine during discrete prenatal or postnatal intervals. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 1: 113-27. PMID 24875723 DOI: 10.1016/0736-5748(83)90038-2  0.31
1982 Lau C, Burke SP, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart. IX. Development of transsynaptic regulation of cardiac adrenergic sensitivity Journal of Pharmacology and Experimental Therapeutics. 233: 675-680. PMID 6292395  0.307
1982 Slotkin TA, Weigel SJ, Whitmore WL, Seidler FJ. Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo. Biochemical Pharmacology. 31: 1899-902. PMID 6285928 DOI: 10.1016/0006-2952(82)90494-4  0.361
1981 Subramanian N, Whitmore WL, Slotkin TA. Transsynaptic modulation of histamine H-1 receptor development in rat brain Federation Proceedings. 40: 461. DOI: 10.1523/Jneurosci.01-06-00674.1981  0.373
1977 Bartolome J, Lau C, Slotkin TA. Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation Journal of Pharmacology and Experimental Therapeutics. 202: 510-518. PMID 894518  0.347
1977 Lau C, Bartolomé M, Slotkin TA. Development of central and peripheral catecholaminergic systems in rats addicted perinatally to methadone Neuropharmacology. 16: 473-478. PMID 21355 DOI: 10.1016/0028-3908(77)90003-X  0.36
1977 ROSENTHAL RN, SLOTKIN TA. DEVELOPMENT OF NICOTINIC RESPONSES IN THE RAT ADRENAL MEDULLA AND LONG‐TERM EFFECTS OF NEONATAL NICOTINE ADMINISTRATION British Journal of Pharmacology. 60: 59-64. PMID 18246 DOI: 10.1111/j.1476-5381.1977.tb16747.x  0.355
1976 Bartolome J, Seidler FJ, Anderson TR, Slotkin TA. Effects of prenatal reserpine administration on development of the rat adrenal medulla and central nervous system Journal of Pharmacology and Experimental Therapeutics. 197: 293-302. PMID 1271281  0.33
1976 Slotkin TA, Lau C, Bartolome M. Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats Journal of Pharmacology and Experimental Therapeutics. 199: 141-148. PMID 978475  0.375
1976 SEIDLER FJ, SLOTKIN TA. EFFECTS OF CHRONIC NICOTINE ADMINISTRATION ON THE DENERVATED RAT ADRENAL MEDULLA British Journal of Pharmacology. 56: 201-207. PMID 3249 DOI: 10.1111/j.1476-5381.1976.tb07443.x  0.321
Low-probability matches (unlikely to be authored by this person)
2022 Hawkey AB, Pippen E, Kenou B, Holloway Z, Slotkin TA, Seidler FJ, Levin ED. Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure. Toxicology. 472: 153189. PMID 35452779 DOI: 10.1016/j.tox.2022.153189  0.299
2008 Slotkin TA, Seidler FJ, Wood CR, Lau C. Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants. Brain Research Bulletin. 76: 531-5. PMID 18534262 DOI: 10.1016/j.brainresbull.2008.03.002  0.299
2008 Roegge CS, Timofeeva OA, Seidler FJ, Slotkin TA, Levin ED. Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Research Bulletin. 75: 166-72. PMID 18158111 DOI: 10.1016/J.Brainresbull.2007.08.008  0.299
2014 Slotkin TA, Card J, Stadler A, Levin ED, Seidler FJ. Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene. Neurotoxicology and Teratology. 43: 19-24. PMID 24642111 DOI: 10.1016/j.ntt.2014.03.002  0.299
1988 Slotkin TA. Perinatal exposure to methadone: How do early biochemical alterations cause neurofunctional disturbances? Progress in Brain Research. 73: 265-279. PMID 3047797  0.298
2003 Dam K, Seidler FJ, Slotkin TA. Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics. Brain Research Bulletin. 59: 261-5. PMID 12464398 DOI: 10.1016/S0361-9230(02)00874-2  0.298
2013 Slotkin TA, Cooper EM, Stapleton HM, Seidler FJ. Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos? Environmental Toxicology and Pharmacology. 36: 284-7. PMID 23686008 DOI: 10.1016/J.Etap.2013.04.003  0.298
2006 Slotkin TA, Pinkerton KE, Tate CA, Seidler FJ. Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke. Brain Research. 1111: 30-5. PMID 16876770 DOI: 10.1016/j.brainres.2006.06.094  0.297
2006 Slotkin TA, Tate CA, Ryde IT, Levin ED, Seidler FJ. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environmental Health Perspectives. 114: 1542-6. PMID 17035140 DOI: 10.1289/ehp.9337  0.296
1986 Slotkin TA, Cowdery TS, Orband L, Pachman S, Whitmore WL. Effects of neonatal hypoxia on brain development in the rat: immediate and long-term biochemical alterations in discrete regions. Brain Research. 374: 63-74. PMID 3719331 DOI: 10.1016/0006-8993(86)90395-1  0.295
2007 Jacobsen LK, Slotkin TA, Mencl WE, Frost SJ, Pugh KR. Gender-specific effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attention. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2453-64. PMID 17375135 DOI: 10.1038/Sj.Npp.1301398  0.294
2013 Slotkin TA, Card J, Infante A, Seidler FJ. BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. Neurotoxicology and Teratology. 37: 13-7. PMID 23422510 DOI: 10.1016/j.ntt.2013.02.001  0.294
2006 Slotkin TA. Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos Toxicology of Organophosphate &Amp; Carbamate Compounds. 293-314. DOI: 10.1016/B978-012088523-7/50022-3  0.294
1989 Slotkin TA, Windh R, Whitmore WL, Seidler FJ. Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Research Bulletin. 21: 737-40. PMID 3219605 DOI: 10.1016/0361-9230(88)90040-8  0.294
1983 Slotkin TA. Effects of perinatal exposure to methadone on development of neurotransmission: biochemical bases for behavioral alterations Monographs in Neural Sciences. 9: 153-158. PMID 6136907  0.292
1998 McGrath KE, Seidler FJ, Slotkin TA. Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. Brain Research. Developmental Brain Research. 104: 209-13. PMID 9466725 DOI: 10.1016/S0165-3806(97)00144-2  0.292
2009 Slotkin T, Seidler F. Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. Brain Research Bulletin. 78: 211-25. PMID 18812211 DOI: 10.1016/j.brainresbull.2008.08.021  0.292
2004 Vatury O, Barg J, Slotkin TA, Yanai J. Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure Brain Research Bulletin. 63: 25-32. PMID 15121236 DOI: 10.1016/j.brainresbull.2003.11.004  0.292
2005 Roy TS, Sharma V, Seidler FJ, Slotkin TA. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Brain Research. Developmental Brain Research. 155: 71-80. PMID 15763277 DOI: 10.1016/j.devbrainres.2004.12.004  0.291
2010 Yanai J, Brick-Turin Y, Dotan S, Langford R, Pinkas A, Slotkin TA. A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity. Neurotoxicology and Teratology. 32: 109-13. PMID 19217940 DOI: 10.1016/j.ntt.2009.02.001  0.289
1986 Bell JM, Slotkin TA. Polyamines as intermediates in developmental neurotoxic events Neurotoxicology. 7: 147-160. PMID 3097591  0.289
2007 Zerrate MC, Pletnikov M, Connors SL, Vargas DL, Seidler FJ, Zimmerman AW, Slotkin TA, Pardo CA. Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. The Journal of Pharmacology and Experimental Therapeutics. 322: 16-22. PMID 17400887 DOI: 10.1124/jpet.107.121483  0.288
2006 Jameson RR, Seidler FJ, Qiao D, Slotkin TA. Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environmental Health Perspectives. 114: 667-72. PMID 16675418 DOI: 10.1289/ehp.8750  0.287
2011 Slotkin TA. Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? Reproductive Toxicology (Elmsford, N.Y.). 31: 297-301. PMID 20850519 DOI: 10.1016/j.reprotox.2010.07.012  0.286
1990 Lau C, Cameron A, Antolick L, Slotkin TA. Trophic control of the ornithine decarboxylase/polyamine system in neonatal rat brain regions: lesions caused by 6-hydroxydopamine produce effects selective for cerebellum Developmental Brain Research. 52: 167-173. PMID 2110039 DOI: 10.1016/0165-3806(90)90232-N  0.284
1981 Lau C, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart. VII. Suppression of sympathetic responses by dexamethasone Journal of Pharmacology and Experimental Therapeutics. 216: 6-11. PMID 6256527  0.284
1999 Dam K, Seidler FJ, Slotkin TA. Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes. Brain Research. Developmental Brain Research. 118: 129-33. PMID 10611511 DOI: 10.1016/S0165-3806(99)00139-X  0.284
1998 Roy TS, Andrews JE, Seidler FJ, Slotkin TA. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. Teratology. 58: 62-8. PMID 9787407 DOI: 10.1002/(SICI)1096-9926(199808)58:2<62::AID-TERA7>3.0.CO;2-2  0.283
1984 Bartolome J, Whitmore WL, Slotkin TA. Effects of neonatal mercuric chloride administration on growth and biochemical development of neuronal and non-neuronal tissues in the rat: Comparison with methylmercury Toxicology Letters. 22: 101-111. PMID 6147034 DOI: 10.1016/0378-4274(84)90052-3  0.282
1983 Morris G, Seidler FJ, Slotkin TA. Stimulation of ornithine decarboxylase by histamine or norepinephrine in brain regions of the developing rat: Evidence for biogenic amines as trophic agents in neonatal brain development Life Sciences. 32: 1565-1571. PMID 6835005 DOI: 10.1016/0024-3205(83)90862-7  0.28
1990 Kudlacz EM, Slotkin TA. Regulation of neonatal rat lung compliance by β-adrenergic receptor stimulation: Effects of prenatal exposure to terbutaline or dexamethasone Journal of Developmental Physiology. 14: 307-310. PMID 2101403  0.28
2007 Buznikov GA, Nikitina LA, Rakić LM, Milosević I, Bezuglov VV, Lauder JM, Slotkin TA. The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. Brain Research Bulletin. 74: 221-31. PMID 17720543 DOI: 10.1016/J.Brainresbull.2007.06.012  0.279
1986 Slotkin TA, Kavlock RJ, Cowdery T, Orband L, Bartolome M, Whitmore WL, Bartolome J. Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat. Toxicology. 41: 95-106. PMID 3018964 DOI: 10.1016/0300-483X(86)90107-1  0.278
1991 Slotkin TA, Seidler FJ, Kavlock RJ, Bartolome JV. Fetal dexamethasone exposure impairs cellular development in neonatal rat heart and kidney: effects on DNA and protein in whole tissues. Teratology. 43: 301-6. PMID 2048038 DOI: 10.1002/tera.1420430404  0.277
2018 Slotkin TA, Ko A, Seidler FJ. Does Growth Impairment Underlie the Adverse Effects of Dexamethasone on Development of Noradrenergic Systems? Toxicology. PMID 29935188 DOI: 10.1016/j.tox.2018.06.008  0.275
2011 Powers CM, Levin ED, Seidler FJ, Slotkin TA. Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. Neurotoxicology and Teratology. 33: 329-32. PMID 21035540 DOI: 10.1016/j.ntt.2010.10.006  0.274
1987 Slotkin TA, Orband-Miller L, Queen KL. Do catecholamines contribute to the effects of neonatal hypoxia on development of brain and heart? Influence of concurrent α-adrenergic blockade on ornithine decarboxylase activity International Journal of Developmental Neuroscience. 5: 135-143. PMID 2845716 DOI: 10.1016/0736-5748(87)90059-1  0.273
2010 Lassiter TL, Ryde IT, Levin ED, Seidler FJ, Slotkin TA. Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits. Brain Research Bulletin. 81: 85-91. PMID 19615431 DOI: 10.1016/j.brainresbull.2009.07.002  0.272
1981 Slotkin TA, Weigel SJ, Barnes GA, Whitmore WL, Seidler FJ. Alterations in the development of catecholamine turnover induced by perinatal methadone: Differences in central vs. peripheral sympathetic nervous systems Life Sciences. 29: 2519-2525. PMID 7321774 DOI: 10.1016/0024-3205(81)90707-4  0.271
1998 Slotkin TA, Zhang J, McCook EC, Seidler FJ. Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats. Brain Research. 800: 236-44. PMID 9685660 DOI: 10.1016/S0006-8993(98)00518-6  0.27
1983 Slotkin TA, Slepetis RJ, Weigel SJ, Whitmore WL. Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. Life Sciences. 32: 2897-903. PMID 6855476 DOI: 10.1016/0024-3205(83)90326-0  0.27
1988 Navarro HA, Lachowicz J, Bartolome J, Whitmore WL, Slotkin TA. Effects of prenatal dexamethasone on development of ornithine decarboxylase activity in brain and peripheral tissues of rats. Pediatric Research. 24: 465-9. PMID 3174289 DOI: 10.1203/00006450-198810000-00009  0.27
1992 Carlos RQ, Seidler FJ, Slotkin TA. Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: a critical period for regionally selective alterations? Teratology. 46: 45-59. PMID 1641811 DOI: 10.1002/tera.1420460108  0.27
2003 Rhodes MC, Nyska A, Seidler FJ, Slotkin TA. Does Terbutaline Damage the Developing Heart? Birth Defects Research Part B - Developmental and Reproductive Toxicology. 68: 449-455. PMID 14745978 DOI: 10.1002/bdrb.10043  0.269
1977 Lau C, Bartolomé J, Seidler F, Slotkin T. Critical periods for effects of prenatal reserpine administration on development of rat brain and adrenal medulla Neuropharmacology. 16: 799-809. DOI: 10.1016/0028-3908(77)90141-1  0.269
1996 Thai L, Galluzzo JM, McCook EC, Seidler FJ, Slotkin TA. Atypical regulation of hepatic adenylyl cyclase and adrenergic receptors during a critical developmental period: agonists evoke supersensitivity accompanied by failure of receptor down-regulation. Pediatric Research. 39: 697-707. PMID 8848348 DOI: 10.1203/00006450-199604000-00023  0.268
2004 Kreider ML, Seidler FJ, Cousins MM, Tate CA, Slotkin TA. Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain. Brain Research. Developmental Brain Research. 152: 233-9. PMID 15351511 DOI: 10.1016/j.devbrainres.2004.07.001  0.268
1984 Slotkin TA, Bartolome J, Persons D, Whitmore WL. Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase. Life Sciences. 35: 1125-31. PMID 6434889 DOI: 10.1016/0024-3205(84)90078-X  0.268
2012 Slotkin TA, Seidler FJ. Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. Neurotoxicology and Teratology. 34: 232-41. PMID 22222554 DOI: 10.1016/j.ntt.2011.12.001  0.268
2012 Rauh VA, Perera FP, Horton MK, Whyatt RM, Bansal R, Hao X, Liu J, Barr DB, Slotkin TA, Peterson BS. Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proceedings of the National Academy of Sciences of the United States of America. 109: 7871-6. PMID 22547821 DOI: 10.1073/Pnas.1203396109  0.267
1990 Slotkin TA, Kudlacz EM, Lappi SE, Tayyeb MI, Seidler FJ. Fetal terbutaline exposure causes selective postnatal increases in cerebellar α-adrenergic receptor binding Life Sciences. 47: 2051-2057. PMID 2177130 DOI: 10.1016/0024-3205(90)90440-3  0.267
2007 Levin E, Linney E, Slotkin T. Complementary zebrafish and rat models of developmental neurobehavioral toxicity: The case of organophosphate pesticide exposure Neurotoxicology and Teratology. 29: 406. DOI: 10.1016/J.NTT.2007.03.038  0.266
1987 Slotkin TA, Orband L, Cowdery T, Kavlock RJ, Bartolome J. Prenatal exposure to methylmercury alters development of adrenergic receptor binding sites in peripheral sympathetic target tissues. Toxicology Letters. 35: 285-95. PMID 3029903 DOI: 10.1016/0378-4274(87)90218-9  0.265
1998 Slotkin TA, Zhang J, McCook EC, Seidler FJ. Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. Brain Research. Developmental Brain Research. 111: 11-24. PMID 9804869 DOI: 10.1016/S0165-3806(98)00115-1  0.265
2004 Kreider ML, Seidler FJ, Slotkin TA. β-Adrenoceptor modulation of transiently overexpressed α 2-adrenoceptors in brain and peripheral tissues: Cellular mechanisms underlying the developmental toxicity of terbutaline Brain Research Bulletin. 62: 305-314. PMID 14709345 DOI: 10.1016/j.brainresbull.2003.09.017  0.265
2009 Slotkin TA, Levin ED, Seidler FJ. Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicology and Teratology. 31: 11-7. PMID 18773955 DOI: 10.1016/j.ntt.2008.08.004  0.265
1980 Bartolome J, Huguenard J, Slotkin TA. Role of ornithine decarboxylase in cardiac growth and hypertrophy Science. 210: 793-794. PMID 6449079 DOI: 10.1126/Science.6449079  0.265
1982 Bartolome J, Chait EA, Trepanier P, Whitmore WL, Weigel S, Slotkin TA. Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues. Toxicology Letters. 13: 267-76. PMID 7147271 DOI: 10.1016/0378-4274(82)90222-3  0.265
1991 Huff RA, Seidler FJ, Slotkin TA. Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver. Life Sciences. 48: 1059-65. PMID 1847731 DOI: 10.1016/0024-3205(91)90507-8  0.265
2006 Roegge C, Timofeva O, Seidler F, Slotkin TA, Levin ED. Persisting effects of early postnatal diazinon exposure on emotional reactivity in rats Neurotoxicology and Teratology. 28: 709. DOI: 10.1016/J.Ntt.2006.09.015  0.264
1976 Bartolome J, Lau C, Slotkin TA. Development of cardiac biochemical responses to sympathetic stimulation: effects of nicotine and reserpine Pharmacologist. 18.  0.263
2014 Cauley M, Burke D, Hall B, Seidler F, Slotkin T, Levin E. Sex-selective interaction of prenatal nicotine with neonatal chlorpyrifos on novel object recognition in rats Neurotoxicology and Teratology. 43: 88-89. DOI: 10.1016/J.Ntt.2014.04.043  0.262
1989 Hou QC, Slotkin TA. Effects of prenatal dexamethasone or terbutaline exposure on development of neural and intrinsic control of heart rate Pediatric Research. 26: 554-555. PMID 2602033  0.262
1999 Zeiders JL, Seidler FJ, Iaccarino G, Koch WJ, Slotkin TA. Ontogeny of cardiac β-adrenoceptor desensitization mechanisms: Agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling Journal of Molecular and Cellular Cardiology. 31: 413-423. PMID 10093053 DOI: 10.1006/Jmcc.1998.0875  0.262
1982 Lau C, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart. VIII. Slowed development of noradrenergic synapses resulting from hypothyroidism Journal of Pharmacology and Experimental Therapeutics. 220: 629-636. PMID 6278128  0.262
2009 Slotkin TA, Seidler FJ. Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. Brain Research Bulletin. 80: 17-21. PMID 19539729 DOI: 10.1016/j.brainresbull.2009.06.003  0.262
2009 Slotkin TA, Ryde IT, Wrench N, Card JA, Seidler FJ. Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions. Neurotoxicology and Teratology. 31: 183-6. PMID 19452616 DOI: 10.1016/j.ntt.2008.12.007  0.261
1987 Seidler FJ, Brown KK, Smith PG, Slotkin TA. Toxic effects of hypoxia on neonatal cardiac function in the rat: α-adrenergic mechanisms Toxicology Letters. 37: 79-84. PMID 3035753 DOI: 10.1016/0378-4274(87)90170-6  0.261
1986 Seidler FJ, Slotkin TA. Non-neurogenic adrenal catecholamine release in the neonatal rat: Exocytosis or diffusion? Developmental Brain Research. 28: 274-277. DOI: 10.1016/0165-3806(86)90031-3  0.261
1975 Slotkin TA, Anderson TR. Sympatho-adrenal development in perinatally addicted rats Addictive Diseases. 2: 293-306. PMID 240252  0.261
1997 Slotkin TA, Wang XF, Symonds HS, Seidler FJ. Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain. Brain Research. Developmental Brain Research. 99: 61-5. PMID 9088566 DOI: 10.1016/S0165-3806(96)00199-X  0.261
1982 Chantry CJ, Seidler FJ, Slotkin TA. Non-neurogenic mechanism for reserpine-induced release of catecholamines from the adrenal medulla of neonatal rats: possible modulation by opiate receptors. Neuroscience. 7: 673-8. PMID 6280102 DOI: 10.1016/0306-4522(82)90073-2  0.26
1977 Thadani PV, Lau C, Slotkin TA, Schanberg SM. Effect of maternal ethanol ingestion on neonatal rat brain and heart ornithine decarboxylase. Biochemical Pharmacology. 26: 523-7. PMID 849350 DOI: 10.1016/0006-2952(77)90328-8  0.26
2009 Lassiter TL, MacKillop EA, Ryde IT, Seidler FJ, Slotkin TA. Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. Brain Research Bulletin. 78: 313-22. PMID 18977280 DOI: 10.1016/j.brainresbull.2008.09.020  0.259
1990 Navarro HA, Kudlacz EM, Eylers JP, Slotkin TA. Prenatal dexamethasone administration disrupts the pattern of cellular development in rat lung. Teratology. 40: 433-8. PMID 2623631 DOI: 10.1002/tera.1420400504  0.258
1991 Duncan CP, Seidler FJ, Slotkin TA. Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions. Brain Research. Developmental Brain Research. 58: 67-71. PMID 1826644 DOI: 10.1016/0165-3806(91)90238-E  0.258
2008 Buznikov GA, Nikitina LA, Seidler FJ, Slotkin TA, Bezuglov VV, Milosević I, Lazarević L, Rogac L, Ruzdijić S, Rakić LM. Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids. Neurotoxicology and Teratology. 30: 503-9. PMID 18565728 DOI: 10.1016/j.ntt.2008.05.003  0.258
2008 Lassiter TL, Ryde IT, Mackillop EA, Brown KK, Levin ED, Seidler FJ, Slotkin TA. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environmental Health Perspectives. 116: 1456-62. PMID 19057696 DOI: 10.1289/ehp.11673  0.257
1990 Duncan CP, Seidler FJ, Lappi SE, Slotkin TA. Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. Brain Research. Developmental Brain Research. 55: 29-33. PMID 2170056 DOI: 10.1016/0165-3806(90)90102-5  0.257
1970 Slotkin T, DiStefano V. Urinary metabolites of harmine in the rat and their inhibition of monoamine oxidase Biochemical Pharmacology. 19: 125-131. PMID 5507632 DOI: 10.1016/0006-2952(70)90333-3  0.256
1995 Slotkin TA, Lorber BA, McCook EC, Barnes GA, Seidler FJ. Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase Developmental Brain Research. 88: 17-29. PMID 7493404 DOI: 10.1016/0165-3806(95)00067-N  0.256
1992 Pracyk JB, Slotkin TA. Thyroid hormone regulates ontogeny of beta adrenergic receptors and adenylate cyclase in rat heart and kidney: Effects of propylthiouracil- induced perinatal hypothyroidism Journal of Pharmacology and Experimental Therapeutics. 261: 951-958. PMID 1318378  0.256
1977 Bartolomé J, Bartolomé M, Seidler J, Anderson TR, Slotkin TA. Effects of early postnatal guanethidine administration on adrenal medulla and brain of developing rats. Biochemical Pharmacology. 25: 2387-90. PMID 999726 DOI: 10.1016/0006-2952(76)90033-2  0.256
2010 Pinkas A, Slotkin TA, Brick-Turin Y, Van der Zee EA, Yanai J. Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. Neurotoxicology and Teratology. 32: 182-6. PMID 19945530 DOI: 10.1016/j.ntt.2009.11.004  0.255
1994 Slotkin TA, Lau C, Seidler FJ. β-Adrenergic Receptor Overexpression in the Fetal Rat: Distribution, Receptor Subtypes, and Coupling to Adenylate Cyclase Activity via G-Proteins Toxicology and Applied Pharmacology. 129: 223-234. PMID 7992312 DOI: 10.1006/taap.1994.1247  0.255
2016 Slotkin TA, Skavicus S, Card J, Giulio RT, Seidler FJ. In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. Toxicology. 377: 49-56. PMID 28049045 DOI: 10.1016/j.tox.2016.12.008  0.254
1977 Thadani PV, Slotkin TA, Schanberg SM. Effects of late prenatal or early postnatal ethanol exposure on ornithine decarboxylase activity in brain and heart of developing rats. Neuropharmacology. 16: 289-93. PMID 859687 DOI: 10.1016/0028-3908(77)90109-5  0.253
1985 Jones LS, Gauger LL, Davis JN, Slotkin TA, Bartolome JV. Postnatal development of brain alpha 1-adrenergic receptors: in vitro autoradiography with [125I]HEAT in normal rats and rats treated with alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. Neuroscience. 15: 1195-1202. PMID 2864658 DOI: 10.1016/0306-4522(85)90262-3  0.252
2008 Yanai J, Dotan S, Goz R, Pinkas A, Seidler FJ, Slotkin TA, Zimmerman F. Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development. Journal of Toxicology and Environmental Health. Part A. 71: 131-3. PMID 18080903 DOI: 10.1080/15287390701613280  0.252
1981 Subramanian N, Whitmore WL, Slotkin TA. Trans-synaptic modulation of histamine H-1 receptor development in rat brain Journal of Neuroscience. 1: 674-678. PMID 7346575  0.249
1988 Bell JM, Whitmore WL, Queen KL, Orband-Miller L, Slotkin TA. Biochemical determinants of growth sparing during neonatal nutritional deprivation or enhancement: ornithine decarboxylase, polyamines, and macromolecules in brain regions and heart. Pediatric Research. 22: 599-604. PMID 2446242 DOI: 10.1203/00006450-198711000-00024  0.249
2005 Kreider ML, Levin ED, Seidler FJ, Slotkin TA. Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1617-23. PMID 15812569 DOI: 10.1038/sj.npp.1300716  0.248
2005 Slotkin TA, Cousins MM, Tate CA, Seidler FJ. Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 52-7. PMID 15367926 DOI: 10.1038/sj.npp.1300569  0.247
1996 Slotkin TA, Barnes GA, McCook EC, Seidler FJ. Programming of brainstem serotonin transporter development by prenatal glucocorticoids Developmental Brain Research. 93: 155-161. PMID 8804702 DOI: 10.1016/0165-3806(96)00027-2  0.247
2019 Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. Corrigendum to "The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems". Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30615185 DOI: 10.1093/toxsci/kfy304  0.247
2000 Crumpton TL, Seidler FJ, Slotkin TA. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: Effects on nuclear transcription factors involved in cell replication and differentiation Brain Research. 857: 87-98. PMID 10700556 DOI: 10.1016/S0006-8993(99)02357-4  0.247
1983 Morris G, Lau C, Slotkin TA. Regulation of brain ornithine decarboxylase activity in the neonatal rat European Journal of Pharmacology. 88: 177-184. PMID 6852109 DOI: 10.1016/0014-2999(83)90004-3  0.246
2006 Jameson RR, Seidler FJ, Qiao D, Slotkin TA. Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1647-58. PMID 16319912 DOI: 10.1038/sj.npp.1300967  0.245
1978 Bareis DL, Slotkin TA. Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adult rats Journal of Pharmacology and Experimental Therapeutics. 205: 164-174. PMID 633081  0.245
2008 Slotkin TA, Seidler FJ. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicology and Applied Pharmacology. 233: 211-9. PMID 18835401 DOI: 10.1016/j.taap.2008.08.020  0.245
1993 Zahalka EA, Seidler FJ, Lappi SE, Yanai J, Slotkin TA. Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression Brain Research. 601: 221-229. PMID 8431769 DOI: 10.1016/0006-8993(93)91714-4  0.245
1985 Seidler FJ, Slotkin TA. Adrenomedullary function in the neonatal rat: responses to acute hypoxia The Journal of Physiology. 358: 1-16. PMID 2858585 DOI: 10.1113/jphysiol.1985.sp015536  0.245
1975 Anderson TR, Slotkin TA. Maturation of the adrenal medulla-IV. Effects of morphine Biochemical Pharmacology. 24: 1469-1474. PMID 7 DOI: 10.1016/0006-2952(75)90020-9  0.244
1983 Slotkin TA, Weigel SJ, Seidler FJ, Whitmore WL. Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment. Toxicology Letters. 14: 131-5. PMID 7167972 DOI: 10.1016/0378-4274(82)90041-8  0.243
1982 Seidler FJ, Whitmore WL, Slotkin TA. Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake? Developmental Neuroscience. 5: 13-8. PMID 6125371 DOI: 10.1159/000112657  0.243
1984 Slotkin TA, Slepetis RJ. Obligatory role of thyroid hormones in development of peripheral sympathetic and central nervous system catecholaminergic neurons: Effects of propylthiouracil-induced hypothyroidism on transmitter levels, turnover and release Journal of Pharmacology and Experimental Therapeutics. 230: 53-61. PMID 6747831  0.243
2011 Dishaw LV, Powers CM, Ryde IT, Roberts SC, Seidler FJ, Slotkin TA, Stapleton HM. Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. Toxicology and Applied Pharmacology. 256: 281-9. PMID 21255595 DOI: 10.1016/J.Taap.2011.01.005  0.243
1987 Slotkin TA, Kavlock RJ, Cowdery T, Orband L, Bartolome M, Gray JA, Rehnberg BF, Bartolome J. Functional consequences of prenatal methylmercury exposure: effects on renal and hepatic responses to trophic stimuli and on renal excretory mechanisms. Toxicology Letters. 34: 231-45. PMID 3798482 DOI: 10.1016/0378-4274(86)90215-8  0.241
2004 Slotkin TA. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: A personal view from an academic perspective Neurotoxicology. 25: 631-640. PMID 15183016 DOI: 10.1016/S0161-813X(03)00050-0  0.24
2000 Slotkin TA, Seidler FJ, Ali SF. Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. Brain Research. 879: 163-73. PMID 11011018 DOI: 10.1016/S0006-8993(00)02767-0  0.24
1975 SLOTKIN TA. EFFECTS OF RESERPINE ON THE ADRENAL MEDULLA OF THE SPONTANEOUSLY HYPERTENSIVE RAT British Journal of Pharmacology. 53: 349-356. PMID 1137729 DOI: 10.1111/j.1476-5381.1975.tb07370.x  0.24
1983 Slotkin TA, Whitmore WL, Lerea L, Slepetis RJ, Weigel SJ, Trepanier PA, Seidler FJ. Role of ornithine decarboxylase and the polyamines in nervous system development: Short-term postnatal administration of α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 1: 7-16. PMID 24875600 DOI: 10.1016/0736-5748(83)90004-7  0.239
2008 Slotkin TA, Seidler FJ, Fumagalli F. Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Research Bulletin. 76: 424-38. PMID 18502319 DOI: 10.1016/j.brainresbull.2008.01.001  0.239
1986 Bell JM, Whitmore WL, Slotkin TA. Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity. Neuroscience. 17: 399-407. PMID 2422585 DOI: 10.1016/0306-4522(86)90255-1  0.238
1984 Slotkin TA, Persons D, Slepetis RJ, Taylor D, Bartolome J. Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. Teratology. 30: 211-24. PMID 6208628 DOI: 10.1002/tera.1420300209  0.237
2008 Pauly JR, Slotkin TA. Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatrica (Oslo, Norway : 1992). 97: 1331-7. PMID 18554275 DOI: 10.1111/j.1651-2227.2008.00852.x  0.235
1995 Slotkin TA, Lappi SE, Seidler FJ. β-Adrenergic Control of c-fos Expression in Fetal and Neonatal Rat Tissues: Relationship to Cell Differentiation and Teratogenesis Toxicology and Applied Pharmacology. 133: 188-195. PMID 7544033 DOI: 10.1006/taap.1995.1141  0.235
1982 Smith P, Slotkin TA, Mills E. Development of sympathetic ganglionic neurotransmission in the neonatal rat. Pre- and postganglionic nerve response to asphyxia and 2-deoxyglucose Neuroscience. 7: 501-507. PMID 6281684 DOI: 10.1016/0306-4522(82)90283-4  0.235
1980 Bartolome J, Mills E, Lau C, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart. V. Development of baroreceptor control of sympathetic tone Journal of Pharmacology and Experimental Therapeutics. 215: 596-600. PMID 6255133  0.235
1991 Pracyk JB, Slotkin TA. Thyroid hormone differentially regulates development of β-adrenergic receptors, adenylate cyclase and ornithine decarboxylase in rat heart and kidney Journal of Developmental Physiology. 16: 251-261. PMID 1667405  0.235
2000 Crumpton TL, Seidler FJ, Slotkin TA. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos? Developmental Brain Research. 121: 189-195. PMID 10876031 DOI: 10.1016/S0165-3806(00)00045-6  0.234
2001 Steingart RA, Silverman WF, Barron S, Slotkin TA, Awad Y, Yanai J. Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits. Brain Research. Developmental Brain Research. 125: 9-19. PMID 11154756 DOI: 10.1016/S0165-3806(00)00123-1  0.234
1981 Subramanian N, Whitmore WL, Seidler FJ, Slotkin TA. Ontogeny of histaminergic neurotransmission in the rat brain: concomitant development of neuronal histamine, H-1 receptors, and H-1 receptor-mediated stimulation of phospholipid turnover. Journal of Neurochemistry. 36: 1137-41. PMID 6259281 DOI: 10.1111/j.1471-4159.1981.tb01710.x  0.234
1975 Slotkin TA, Seidler FJ. Acute and chronic effects of nicotine on synthesis and storage of catecholamines in the rat adrenal medulla Life Sciences. 16: 1613-1622. PMID 567 DOI: 10.1016/0024-3205(75)90079-X  0.233
1983 Slotkin TA, Bartolome J, Whitmore WL. Developmental effects of α-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines Life Sciences. 33: 2137-2145. PMID 6645794 DOI: 10.1016/0024-3205(83)90338-7  0.233
1992 Slotkin TA, Seidler FJ, Kavlock RJ, Bartolome JV. Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney. Teratology. 45: 303-12. PMID 1631783 DOI: 10.1002/tera.1420450309  0.232
1993 Bian X, Seidler FJ, Slotkin TA. Fetal dexamethasone exposure interferes with establishment of cardiac noradrenergic innervation and sympathetic activity Teratology. 47: 109-117. PMID 8446924 DOI: 10.1002/tera.1420470203  0.232
2014 Slotkin TA, Johnson A, Whitmore WL, Slepetis RJ. Ornithine decarboxylase and polyamines in developing rat brain and heart: Effects of perinatal hypothyroidism. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 2: 155-61. PMID 24873959 DOI: 10.1016/0736-5748(84)90007-8  0.232
1981 Smith PG, Mills E, Slotkin TA. Maturation of sympathetic neurotransmission in the efferent pathway to the rat heart: Ultrastructural analysis of ganglionic synaptogenesis in euthyroid and hyperthyroid neonates Neuroscience. 6: 911-918. PMID 6264344 DOI: 10.1016/0306-4522(81)90172-X  0.231
1986 Bell JM, Madwed DS, Slotkin TA. Critical development periods for inhibition of ornithine decarboxylase by alpha-difluoromethylornithine: effects on ontogeny of sensorimotor behavior. Neuroscience. 19: 457-64. PMID 3095679 DOI: 10.1016/0306-4522(86)90274-5  0.23
2010 Slotkin TA, Seidler FJ, Fumagalli F. Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model. Neurotoxicology and Teratology. 32: 42-51. PMID 19130878 DOI: 10.1016/j.ntt.2008.11.006  0.229
1997 Renick SE, Seidler FJ, McCook EC, Slotkin TA. Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: Effects of sympathectomy Pediatric Research. 41: 359-363. PMID 9078535 DOI: 10.1203/00006450-199703000-00009  0.229
1982 Slotkin TA, Chantry CJ, Bartolome J. Development of central control of adrenal catecholamine biosynthesis and release Advances in the Biosciences. 36: 95-102.  0.229
1996 Metz LD, Seidler FJ, McCook EC, Slotkin TA. Cardiac alpha-adrenergic receptor expression is regulated by thyroid hormone during a critical developmental period. Journal of Molecular and Cellular Cardiology. 28: 1033-44. PMID 8762041 DOI: 10.1006/jmcc.1996.0096  0.228
1976 Bartolomé J, Slotkin TA. Effects of postnatal reserpine administration on sympatho-adrenal development in the rat Biochemical Pharmacology. 25: 1513-1519. PMID 942452 DOI: 10.1016/0006-2952(76)90070-8  0.227
2013 Behl M, Rao D, Aagaard K, Davidson TL, Levin ED, Slotkin TA, Srinivasan S, Wallinga D, White MF, Walker VR, Thayer KA, Holloway AC. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environmental Health Perspectives. 121: 170-80. PMID 23232494 DOI: 10.1289/Ehp.1205404  0.227
2010 Powers CM, Yen J, Linney EA, Seidler FJ, Slotkin TA. Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival. Neurotoxicology and Teratology. 32: 391-7. PMID 20116428 DOI: 10.1016/j.ntt.2010.01.009  0.226
1988 Slotkin TA, Seidler FJ. Adrenomedullary catecholamine release in the fetus and newborn: Secretory mechanisms and their role in stress and survival Journal of Developmental Physiology. 10: 1-16. PMID 3280659  0.226
2022 Hawkey AB, Evans J, Holloway ZR, Pippen E, Jarrett O, Kenou B, Slotkin TA, Seidler FJ, Levin ED. Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction. Birth Defects Research. PMID 36369782 DOI: 10.1002/bdr2.2125  0.226
1988 Lau C, Ross LL, Whitmore WL, Slotkin TA. Regulation of adrenal chromaffin cell development by the central monoaminergic system: differential control of norepinephrine and epinephrine levels and secretory responses. Neuroscience. 22: 1067-75. PMID 3120031 DOI: 10.1016/0306-4522(87)92981-2  0.226
2008 Connors SL, Levitt P, Matthews SG, Slotkin TA, Johnston MV, Kinney HC, Johnson WG, Dailey RM, Zimmerman AW. Fetal mechanisms in neurodevelopmental disorders. Pediatric Neurology. 38: 163-76. PMID 18279750 DOI: 10.1016/j.pediatrneurol.2007.10.009  0.225
1995 Seidler FJ, Temple SW, McCook EC, Slotkin TA. Cocaine inhibits central noradrenergic and dopaminergic activity during the critical developmental period in which catecholamines influence cell development. Brain Research. Developmental Brain Research. 85: 48-53. PMID 7781166 DOI: 10.1016/0165-3806(94)00186-4  0.225
2006 Slotkin TA, Seidler FJ. Cholinergic receptor subtypes in the olfactory bulbectomy model of depression Brain Research Bulletin. 68: 341-345. PMID 16377441 DOI: 10.1016/j.brainresbull.2005.09.005  0.224
2016 Slotkin TA, Skavicus S, Card J, Levin ED, Seidler FJ. Diverse Neurotoxicants Target the Differentiation of Embryonic Neural Stem Cells into Neuronal and Glial Phenotypes. Toxicology. PMID 27816694 DOI: 10.1016/j.tox.2016.10.015  0.223
1981 Bartolome JV, Schanberg SM, Slotkin TA. Premature development of cardiac sympathetic neurotransmission in the fetal alcohol syndrome. Life Sciences. 28: 571-6. PMID 7010040 DOI: 10.1016/0024-3205(81)90151-X  0.223
1976 Lau C, Thadani PV, Schanberg SM, Slotkin TA. Effects of maternal ethanol ingestion on development of adrenal catecholamines and dopamine-beta-hydroxylase in the offspring. Neuropharmacology. 15: 505-7. PMID 980225 DOI: 10.1016/0028-3908(76)90063-0  0.223
2015 Slotkin TA, Skavicus S, Card J, Levin ED, Seidler FJ. Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors Toxicology. 333: 63-75. DOI: 10.1016/j.tox.2015.04.005  0.223
2003 Buznikov GA, Slotkin TA, Lauder JM. Sea urchin embryos and larvae as biosensors for neurotoxicants. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit1.6. PMID 23045086 DOI: 10.1002/0471140856.Tx0106S16  0.222
1988 Bell JM, Whitmore WL, Slotkin TA. Neonatal nutritional deprivation or enhancement: the cardiac-sympathetic axis and its role in cardiac growth and stress responses. Pediatric Research. 23: 423-7. PMID 3374996 DOI: 10.1203/00006450-198804000-00017  0.222
1979 Lau C, Slotkin TA. Accelerated development of rat sympathetic neurotransmission caused by neonatal triiodothyronine administration Journal of Pharmacology and Experimental Therapeutics. 208: 485-490. PMID 219177  0.221
2007 Jameson RR, Seidler FJ, Slotkin TA. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Environmental Health Perspectives. 115: 65-70. PMID 17366821 DOI: 10.1289/ehp.9487  0.221
2011 Slotkin T. Concerning "Absence of neurotoxicity with medicinal grade terbutaline in the rat model," by M.Y. Owens, K.L. Wallace, N. Mamoon, J. Wyatt-Ashmead and W.A. Bennett. Reproductive Toxicology (Elmsford, N.Y.). 32: 368-9; author reply . PMID 21708245 DOI: 10.1016/J.Reprotox.2011.05.017  0.22
1989 Schweitzer L, Robbins AJ, Slotkin TA. Dendritic development of Purkinje and granule cells in the cerebellar cortex of rats treated postnatally with alpha-difluoromethylornithine. Journal of Neuropathology and Experimental Neurology. 48: 11-22. PMID 2462023 DOI: 10.1097/00005072-198901000-00002  0.219
1980 Slotkin TA, Seidler FJ, Whitmore WL. Effects of maternal methadone administration on ornithine decarboxylase in brain and heart of the offspring: relationships of enzyme activity to dose and to growth impairment in the rat. Life Sciences. 26: 861-7. PMID 7374351 DOI: 10.1016/0024-3205(80)90348-3  0.219
1981 Deskin R, Seidler FJ, Whitmore WL, Slotkin TA. Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain. Journal of Neurochemistry. 36: 1683-90. PMID 6264034 DOI: 10.1111/j.1471-4159.1981.tb00419.x  0.218
1973 Kirshner N, Slotkin T. Recovery of catecholamine stores following secretion by the adrenal medulla Life Sciences. 13. DOI: 10.1016/0024-3205(73)90309-3  0.218
1995 Spraggins YR, Seidler FJ, Slotkin TA. Cocaine exacerbates hypoxia-induced cell damage in the developing brain: effects on ornithine decarboxylase activity and protein synthesis. Biology of the Neonate. 66: 254-66. PMID 7873692 DOI: 10.1159/000244115  0.218
1987 Schweitzer L, Bell JM, Slotkin TA. Impaired morphological development of the dorsal cochlear nucleus in hamsters treated postnatally with α -difluoromethylornithine Neuroscience. 23: 1123-1132. PMID 3125489 DOI: 10.1016/0306-4522(87)90186-2  0.216
1980 Bareis DL, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart. I. Ontogeny of the synaptic vesicle uptake mechanism and correlation with development of synaptic function. Effects of neonatal methadone administration on development of synaptic vesicles Journal of Pharmacology and Experimental Therapeutics. 212: 120-125. PMID 6243356  0.216
1993 Slotkin TA, Johnson DJ, Seidler FJ. Acute effects of cocaine on ornithine decarboxylase activity in fetal and neonatal rat heart: evidence for cardiotoxicity. Biology of the Neonate. 63: 290-6. PMID 8353157 DOI: 10.1159/000243944  0.216
1982 Bartolome J, Trepanier P, Chait EA, Seidler FJ, Deskin R, Slotkin TA. Neonatal methylmercury poisoning in the rat: effects on development of central catecholamine neurotransmitter systems. Toxicology and Applied Pharmacology. 65: 92-9. PMID 6128806 DOI: 10.1016/0041-008X(82)90366-0  0.215
1979 KIRKSEY DF, SLOTKIN TA. CONCOMITANT DEVELOPMENT OF [3H]‐DOPAMINE AND [3H]‐5‐HYDROXYTRYPTAMINE UPTAKE SYSTEMS IN RAT BRAIN REGIONS British Journal of Pharmacology. 67: 387-391. PMID 497539 DOI: 10.1111/j.1476-5381.1979.tb08692.x  0.213
1982 Bartolome J, Lau C, Slotkin TA. Neonatal hyperthyroidism causes premature development of baroreceptor-mediated cardiac sympathetic reflexes Developmental Neuroscience. 5: 208-215. PMID 7128484 DOI: 10.1159/000112678  0.211
2005 Fumagalli F, Bedogni F, Slotkin TA, Racagni G, Riva MA. Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress Neurobiology of Disease. 20: 731-737. PMID 15967670 DOI: 10.1016/J.Nbd.2005.05.005  0.211
2018 Slotkin TA, Skavicus S, Seidler FJ. Developmental Neurotoxicity Resulting from Pharmacotherapy of Preterm Labor, Modeled In Vitro: Terbutaline and Dexamethasone, Separately and Together. Toxicology. PMID 29524569 DOI: 10.1016/j.tox.2018.03.001  0.211
2000 Slotkin TA, Seidler FJ. Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells Breast Cancer Research and Treatment. 64: 259-267. PMID 11200776 DOI: 10.1023/A:1026508605951  0.211
2007 Golub MS, Slotkin TA, Tarantal AF, Pinkerton KE. Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke. Brain Research. 1151: 102-6. PMID 17399690 DOI: 10.1016/J.Brainres.2007.03.001  0.21
1986 Slotkin TA, Bartolome J. Role of ornithine decarboxylase and the polyamines in nervous system development: A review Brain Research Bulletin. 17: 307-320. PMID 3094839 DOI: 10.1016/0361-9230(86)90236-4  0.209
1978 Kirksey DF, Seidler FJ, Slotkin TA. Ontogeny of (--)-[3H]norepinephrine uptake properties of synaptic storage vesicles of rat brain. Brain Research. 150: 367-75. PMID 678975 DOI: 10.1016/0006-8993(78)90287-1  0.208
1976 Slotkin TA, Seidler FJ, Lau C, Bartolomé J, Schanberg SM. Effects of chronic chlorisondamine administration on the sympatho-adrenal axis. Biochemical Pharmacology. 25: 1311-5. PMID 938554 DOI: 10.1016/0006-2952(76)90095-2  0.208
2012 Rauh VA, Slotkin TA, Bansal R. Reply to Juberg: Using the biologically based dose response to compare exposures across species Proceedings of the National Academy of Sciences of the United States of America. 109. DOI: 10.1073/pnas.1209095109  0.207
2007 Slotkin TA, Seidler FJ, Fumagalli F. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environmental Health Perspectives. 115: 909-16. PMID 17589599 DOI: 10.1289/ehp.9901  0.206
2001 Qiao D, Seidler FJ, Slotkin TA. Developmental neurotoxicity of chlorpyrifos modeled in vitro: Comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells Environmental Health Perspectives. 109: 909-913. PMID 11673119  0.206
1979 Slotkin TA, Whitmore WL, Salvaggio M, Seidler FJ. Perinatal methadone addiction affects brain synaptic development of biogenic amine systems in the rat. Life Sciences. 24: 1223-9. PMID 571949 DOI: 10.1016/0024-3205(79)90059-6  0.205
2010 Slotkin TA, Seidler FJ. Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Research. 1353: 36-52. PMID 20682304 DOI: 10.1016/j.brainres.2010.07.073  0.204
1984 Morris G, Slotkin TA. Evidence for a trophic role of catecholamines in rat cerebellar development: Stimulation of brain ornithine decarboxylase (ODC) by isoproterenol (ISO) Federation Proceedings. 43.  0.204
1997 Tan JP, Seidler FJ, Schwinn DA, Page SO, Slotkin TA. A critical period for the role of thyroid hormone in development of renal alpha-adrenergic receptors. Pediatric Research. 42: 93-102. PMID 9212043 DOI: 10.1203/00006450-199707000-00015  0.204
2017 Slotkin TA, Skavicus S, Stapleton HM, Seidler FJ. Brominated and Organophosphate Flame Retardants Target Different Neurodevelopmental Stages, Characterized with Embryonic Neural Stem Cells and Neuronotypic PC12 Cells. Toxicology. PMID 28851516 DOI: 10.1016/J.Tox.2017.08.009  0.203
1978 Slotkin TA, Seidler FJ, Whitmore WL. Methadone inhibits serotonin and norephinephrine uptake into rat brain synaptosomes and synaptic vesicles in vitro but not in vivo. European Journal of Pharmacology. 49: 357-62. PMID 668807 DOI: 10.1016/0014-2999(78)90309-6  0.202
1988 Bell JM, Slotkin TA. Postnatal nutritional status influences development of cardiac adrenergic receptor binding sites Brain Research Bulletin. 21: 893-896. PMID 3224282 DOI: 10.1016/0361-9230(88)90023-8  0.2
2013 Slotkin TA, Seidler FJ. Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor. Neurotoxicology and Teratology. 36: 91-6. PMID 22813780 DOI: 10.1016/j.ntt.2012.07.003  0.199
1976 Bartolome J, Slotkin TA. Effects of antihypertensives on the neonatal rat adrenal medulla Federation Proceedings. 35.  0.195
2002 Zeiders JL, Seidler FJ, Slotkin TA. Ontogeny of G-protein expression: control by beta-adrenoceptors. Brain Research. Developmental Brain Research. 120: 125-34. PMID 10775765 DOI: 10.1016/S0165-3806(99)00188-1  0.195
2000 Slotkin TA, Seidler FJ, Ritchie JC. Regional differences in brain monoamine oxidase subtypes in an animal model of geriatric depression: effects of olfactory bulbectomy in young versus aged rats. Brain Research. 882: 149-54. PMID 11056194 DOI: 10.1016/S0006-8993(00)02859-6  0.195
1980 Lau C, Slotkin TA. Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats Molecular Pharmacology. 18: 247-252. PMID 6158669  0.194
2021 Gearhart-Serna LM, Tacam M, Slotkin TA, Devi GR. Analysis of polycyclic aromatic hydrocarbon intake in the US adult population from NHANES 2005-2014 identifies vulnerable subpopulations, suggests interaction between tobacco smoke exposure and sociodemographic factors. Environmental Research. 111614. PMID 34216610 DOI: 10.1016/j.envres.2021.111614  0.194
1986 Seidler FJ, Slotkin TA. Ontogeny of adrenomedullary responses to hypoxia and hypoglycemia: Role of splanchnic innervation Brain Research Bulletin. 16: 11-14. PMID 3513906 DOI: 10.1016/0361-9230(86)90005-5  0.193
1975 Bartolome J, Slotkin TA. Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine β hydroxylase Psychopharmacology Communications. 1: 465-472. PMID 7001  0.192
2003 Qiao D, Nikitina LA, Buznikov GA, Lauder JM, Seidler FJ, Slotkin TA. The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. Environmental Health Perspectives. 111: 1730-5. PMID 14594623  0.191
1997 Slotkin TA, McCook EC, Ritchie JC, Carroll BJ, Seidler FJ. Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biological Psychiatry. 41: 172-83. PMID 9018387 DOI: 10.1016/S0006-3223(96)00215-6  0.191
1981 Seidler FJ, Slotkin TA. Development of central control of norepinephrine turnover and release in the rat heart: Responses to tyramine, 2-Deoxyglucose and Hydralazine Neuroscience. 6: 2081-2086. PMID 6272159 DOI: 10.1016/0306-4522(81)90047-6  0.191
1979 Slotkin TA. Ornithine decarboxylase as a tool in developmental neurobiology Life Sciences. 24: 1623-1629. PMID 384123 DOI: 10.1016/0024-3205(79)90244-3  0.191
2012 Levin E, Cauley M, Johnson J, Sexton H, Gordon K, Seidler F, Slotkin T. WITHDRAWN: NBTS 2012 abstracts. Neurotoxicology and Teratology. PMID 22607826 DOI: 10.1016/J.Ntt.2012.04.003  0.19
1985 Slotkin TA, Pachman S, Bartolome J, Kavlock RJ. Biochemical and functional alterations in renal and cardiac development resulting from neonatal methylmercury treatment. Toxicology. 36: 231-41. PMID 4049432 DOI: 10.1016/0300-483X(85)90056-3  0.19
1981 Subramanian N, Whitmore WL, Seidler FJ, Slotkin TA. Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism. Life Sciences. 27: 1315-9. PMID 7442445 DOI: 10.1016/0024-3205(80)90225-8  0.19
2009 Pauly JR, Slotkin TA. Material tobacco smoking, nicotine replacement and neurobehavioural development (Acta Paediatrica, International Journal of Paediatrics (2008) 97, (1331-1337)) Acta Paediatrica, International Journal of Paediatrics. 98: 208. DOI: 10.1111/j.1651-2227.2008.01178.x  0.189
1988 Lau C, Bartolome JV, Bartolome MB, Slotkin TA. Central and sympatho-adrenal responses to insulin in adult and neonatal rats. Brain Research. 433: 277-80. PMID 3319047 DOI: 10.1016/0165-3806(87)90031-9  0.186
1979 SEIDLER FJ, SLOTKIN TA. PRESYNAPTIC AND POSTSYNAPTIC CONTRIBUTIONS TO ONTOGENY OF SYMPATHETIC CONTROL OF HEART RATE IN THE PRE‐WEANLING RAT British Journal of Pharmacology. 65: 431-434. PMID 427316 DOI: 10.1111/j.1476-5381.1979.tb07847.x  0.185
1988 Schweitzer L, Nadler JV, Slotkin TA. Ontogenetic changes in laminar distribution of ornithine decarboxylase during development of cerebellar cortex: autoradiographic localization with [3H]alpha-difluoromethylornithine. Neuroscience. 27: 453-64. PMID 3146032 DOI: 10.1016/0306-4522(88)90280-1  0.185
1990 Anderson-Brown T, Slotkin TA, Seidler FJ. Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions Brain Research. 537: 197-202. PMID 2085773 DOI: 10.1016/0006-8993(90)90358-I  0.184
2013 Coppola A, Wenner BR, Ilkayeva O, Stevens RD, Maggioni M, Slotkin TA, Levin ED, Newgard CB. Branched-chain amino acids alter neurobehavioral function in rats. American Journal of Physiology. Endocrinology and Metabolism. 304: E405-13. PMID 23249694 DOI: 10.1152/Ajpendo.00373.2012  0.183
1989 Gray JA, Rehnberg BF, Rogers EH, Lau C, Slotkin TA, Kavlock RJ. Prenatal alpha-difluoromethylornithine treatment: effects on postnatal renal growth and function in the rat. Teratology. 40: 105-11. PMID 2505399 DOI: 10.1002/tera.1420400204  0.182
2008 Buznikov GA, Nikitina LA, Bezuglov VV, Milosević I, Lazarević L, Rogac L, Ruzdijić S, Slotkin TA, Rakić LM. Sea urchin embryonic development provides a model for evaluating therapies against beta-amyloid toxicity. Brain Research Bulletin. 75: 94-100. PMID 18158101 DOI: 10.1016/j.brainresbull.2007.07.026  0.181
2012 Slotkin TA, Seidler FJ. Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. Neurotoxicology and Teratology. 34: 395-402. PMID 22546817 DOI: 10.1016/j.ntt.2012.04.008  0.181
1996 Fumagalli F, Jones SR, Caron MG, Seidler FJ, Slotkin TA. Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain Research. 719: 225-8. PMID 8782886 DOI: 10.1016/0006-8993(96)00119-9  0.181
2011 Slotkin TA, Seidler FJ. Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo. Brain Research Bulletin. 86: 340-7. PMID 21968025 DOI: 10.1016/j.brainresbull.2011.09.017  0.181
1978 Slotkin TA, Salvaggio M, Lau C, Kirksey DF. 3H-Dopamine uptake by synaptic storage vesicles of rat whole brain and brain regions. Life Sciences. 22: 823-30. PMID 642699 DOI: 10.1016/0024-3205(78)90605-7  0.179
1981 DESKIN R, SLOTKIN TA. CENTRAL CATECHOLAMINERGIC LESIONS IN THE DEVELOPING RAT: EFFECTS ON CARDIAC NORADRENALINE LEVELS, TURNOVER AND RELEASE Journal of Autonomic Pharmacology. 1: 205-210. PMID 7338526 DOI: 10.1111/j.1474-8673.1981.tb00448.x  0.178
1980 Slotkin TA, Seidler FJ, Whitmore WL. Precocious development of sympatho-adrenal function in rats whose mothers received methadone. Life Sciences. 26: 1657-63. PMID 6993823 DOI: 10.1016/0024-3205(80)90173-3  0.177
1978 Lau C, Slotkin TA. Acceleration of development of sympathetic nervous system in rat adrenal medulla and heart produced by neonatal triiodothyronine treatment Federation Proceedings. 37.  0.177
1978 Slotkin TA, Seidler FJ, Whitmore WL, Lau C, Salvaggio M, Kirksey DF. Rat brain synaptic vesicles: uptake specificities of [3H]norepinephrine and [3H]serotonin in preparations from whole brain and brain regions. Journal of Neurochemistry. 31: 961-8. PMID 702157 DOI: 10.1111/j.1471-4159.1978.tb00134.x  0.175
1980 Slotkin TA, Schanberg SM, Kuhn CM. Synaptic development in brains of rats exposed perinatally to ethanol. Experientia. 36: 1005-7. PMID 7439320 DOI: 10.1007/BF01953850  0.175
1981 Smith PG, Mills E, Slotkin T. Development of sympathetic ganglionic neurotransmission in the rat Federation Proceedings. 40: 80.  0.174
1970 Slotkin TA, DiStefano V. Cardiovascular and Respiratory Effects of Harmine (34539) Proceedings of the Society For Experimental Biology and Medicine. 133: 662-664. PMID 5414252 DOI: 10.3181/00379727-133-34539  0.172
2007 Slotkin TA, MacKillop EA, Ryde IT, Seidler FJ. Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environmental Health Perspectives. 115: 1306-13. PMID 17805420 DOI: 10.1289/ehp.10194  0.172
1991 Koegler SM, Seidler FJ, Spencer JR, Slotkin TA. Ischemia contributes to adverse effects of cocaine on brain development: suppression of ornithine decarboxylase activity in neonatal rat. Brain Research Bulletin. 27: 829-34. PMID 1786562 DOI: 10.1016/0361-9230(91)90217-8  0.171
2011 Powers CM, Slotkin TA, Seidler FJ, Badireddy AR, Padilla S. Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition. Neurotoxicology and Teratology. 33: 708-14. PMID 21315816 DOI: 10.1016/J.Ntt.2011.02.002  0.171
1998 Slotkin TA, Seidler FJ, Ritchie JC. Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: therapeutic implications. Brain Research Bulletin. 47: 345-8. PMID 9886786 DOI: 10.1016/S0361-9230(98)00111-7  0.169
2011 Turgeman G, Pinkas A, Slotkin TA, Tfilin M, Langford R, Yanai J. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells. Journal of Neuroscience Research. 89: 1185-93. PMID 21520219 DOI: 10.1002/jnr.22631  0.167
1982 Grignolo A, Seidler FJ, Bartolome M, Kuhn CM, Slotkin TA, Schanberg SM. Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone. Life Sciences. 31: 3009-16. PMID 7162362 DOI: 10.1016/0024-3205(82)90068-6  0.166
1977 Bartolome J, Lau C, Slotkin T. Changes of functional development of the sympathetic innervation of the rat heart brought about by neonatal administration of antihypertensive drugs Boletin De Estudios Medicos Y Biologicos. 29: 432-433.  0.165
1986 Morris G, Nadler JV, Slotkin TA. Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine. Neuroscience. 17: 183-8. PMID 3083283 DOI: 10.1016/0306-4522(86)90235-6  0.164
2010 Powers CM, Wrench N, Ryde IT, Smith AM, Seidler FJ, Slotkin TA. Silver impairs neurodevelopment: studies in PC12 cells. Environmental Health Perspectives. 118: 73-9. PMID 20056586 DOI: 10.1289/ehp.0901149  0.163
1980 Slotkin TA, Seidler FJ, Whitmore WL, Salvaggio M, Bareis DL. Release of [3H]norepinephrine from synaptic vesicles isolated from rat brain after the intracisternal administration of [3H]norepinephrine: influence of nucleotides, ions and drugs, and destabilization of transmitter storage caused by acute or chronic lithium administration. Neuroscience. 5: 753-62. PMID 6771674 DOI: 10.1016/0306-4522(80)90168-2  0.162
1980 Lau C, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart. II. Enhanced development of presynaptic and postsynaptic components of noradrenergic synapses as a result of neonatal hyperthyroidism Journal of Pharmacology and Experimental Therapeutics. 212: 126-130. PMID 6243357  0.161
1988 Bell JM, Slotkin TA. Coordination of cell development by the ornithine decarboxylase (ODC)/polyamine pathway as an underlying mechanism in developmental neurotoxic events Progress in Brain Research. 73: 349-362. PMID 3047803  0.161
2008 Slotkin TA, MacKillop EA, Melnick RL, Thayer KA, Seidler FJ. Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. Environmental Health Perspectives. 116: 716-22. PMID 18560525 DOI: 10.1289/ehp.11253  0.161
2010 Dotan S, Pinkas A, Slotkin TA, Yanai J. An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells. Neurotoxicology and Teratology. 32: 481-8. PMID 20211723 DOI: 10.1016/j.ntt.2010.02.003  0.16
1973 Slotkin TA, Edwards K. Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles Biochemical Pharmacology. 22: 549-560. PMID 4692166 DOI: 10.1016/0006-2952(73)90368-7  0.16
1975 Slotkin TA. Maturation of the adrenal medulla-III. Practical and theoretical considerations of age-dependent alterations in kinetics of incorporation of catecholamines and non-catecholamines Biochemical Pharmacology. 24: 89-97. PMID 1092305 DOI: 10.1016/0006-2952(75)90319-6  0.158
1986 Friedman L, Gaines DW, Alleva FR, Seidler FJ, Flynn TJ, Slotkin TA, Balazs T. Macromolecular levels, DNA synthesis and ornithine decarboxylase activity in leg muscles from 6-mercaptopurine-treated rats. Toxicology and Industrial Health. 2: 57-68. PMID 2431517 DOI: 10.1177/074823378600200207  0.157
1976 LAU C, SLOTKIN TA. INDIRECT AND DIRECT INHIBITION OF DOPAMINE β‐HYDROXYLASE BY AMPHETAMINE IN STORAGE VESICLES AND SYNAPTOSOMES British Journal of Pharmacology. 57: 223-228. PMID 779909 DOI: 10.1111/j.1476-5381.1976.tb07471.x  0.157
1980 Bareis DL, Slotkin TA. Maturation of sympathetic neurotransmission in the rat heart-III. Developmental changes in reserpine inhibition of norepinephrine uptake into isolated synaptic vesicles Biochemical Pharmacology. 29: 1595-1598. PMID 6249322 DOI: 10.1016/0006-2952(80)90615-2  0.157
2010 Slotkin TA, Lobner D, Seidler FJ. Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. Brain Research Bulletin. 83: 76-83. PMID 20600679 DOI: 10.1016/J.Brainresbull.2010.06.010  0.155
1976 Anderson TR, Slotkin TA. The role of neural input in the effects of morphine on the rat adrenal medulla Biochemical Pharmacology. 25: 1071-1074. PMID 5098 DOI: 10.1016/0006-2952(76)90499-8  0.155
2010 Slotkin TA, Seidler FJ. Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. Neurotoxicology and Teratology. 32: 124-31. PMID 20004241 DOI: 10.1016/j.ntt.2009.12.001  0.155
1980 Slotkin TA, Burwell B, Lau C. An intracellular opiate receptor Life Sciences. 27: 1975-1978. PMID 6259468 DOI: 10.1016/0024-3205(80)90417-8  0.155
1977 Seidler FJ, Kirksey DF, Lau C, Whitmore WL, Slotkin TA. Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs. Life Sciences. 21: 1075-85. PMID 21338 DOI: 10.1016/0024-3205(77)90105-9  0.154
1990 Slotkin TA, Seidler FJ, Crain BJ, Bell JM, Bissette G, Nemeroff CB. Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. Proceedings of the National Academy of Sciences of the United States of America. 87: 2452-5. PMID 2320567 DOI: 10.1073/Pnas.87.7.2452  0.152
1976 Slotkin TA, Lau C, Bartolomé M, Seidler FJ. Catecholamine synthesis, storage and release in adrenal medulla and whole brain during acute and chronic methadone administration. Biochemical Pharmacology. 25: 2523-7. PMID 10926 DOI: 10.1016/0006-2952(76)90459-7  0.151
1974 Anderson TR, Slotkin TA. Effects of morphine, on the adrenal medulla of developing rats Pharmacologist. 16.  0.149
1986 Smith MA, Bissette G, Slotkin TA, Knight DL, Nemeroff CB. Release of corticotropin-releasing factor from rat brain regions in vitro. Endocrinology. 118: 1997-2001. PMID 3486117 DOI: 10.1210/endo-118-5-1997  0.146
1979 Lau C, Slotkin TA. Regulation of rat heart ornithine decarboxylase: Change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli Molecular Pharmacology. 16: 504-512. PMID 229401  0.145
1979 Bareis DL, Slotkin TA. SYNAPTIC VESICLES ISOLATED FROM RAT HEART: l‐[3H]NOREPINEPHRINE UPTAKE PROPERTIES Journal of Neurochemistry. 32: 345-351. PMID 762551 DOI: 10.1111/j.1471-4159.1979.tb00357.x  0.145
1994 Slotkin TA, Nemeroff CB, Bissette G, Seidler FJ. Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies. The Journal of Clinical Investigation. 94: 696-702. PMID 8040324 DOI: 10.1172/JCI117387  0.145
1981 Evoniuk G, Slotkin TA. pH dependence of [3H]norepinephrine uptake into catecholamine storage vesicles isolated from rat brain, heart and adrenal medulla. Biochemical Pharmacology. 30: 2872-3. PMID 7317082 DOI: 10.1016/0006-2952(81)90430-5  0.144
2003 Oncken CA, Henry KM, Campbell WA, Kuhn CM, Slotkin TA, Kranzler HR. Effect of maternal smoking on fetal catecholamine concentrations at birth. Pediatric Research. 53: 119-24. PMID 12508090 DOI: 10.1203/00006450-200301000-00020  0.143
2010 Barbon A, Fumagalli F, Caracciolo L, Madaschi L, Lesma E, Mora C, Carelli S, Slotkin TA, Racagni G, Di Giulio AM, Gorio A, Barlati S. Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. Journal of Neurochemistry. 114: 397-407. PMID 20456005 DOI: 10.1111/J.1471-4159.2010.06767.X  0.142
1973 Green HO, Slotkin TA. Reserpine like effects of harmine on isolated adrenal medullary vesicles Molecular Pharmacology. 9: 748-755. PMID 4148654  0.14
1981 Subramanian N, Slotkin TA. Solubilization of a [3H]cimetidine binding site from rat brain. A clonidine-sensitive H-2 receptor subtype? Molecular Pharmacology. 20: 240-243. PMID 6272082  0.14
1986 Slotkin TA, Whitmore WL, Dew KL, Kilts CD. Uptake of serotonin into rat platelets and synaptosomes: comparative structure-activity relationships, energetics and evaluation of the effects of acute and chronic nortriptyline administration. Brain Research Bulletin. 17: 67-73. PMID 3756546 DOI: 10.1016/0361-9230(86)90162-0  0.14
1974 Anderson TR, Slotkin TA. Acute and chronic effects of morphine on rat adrenal medulla Federation Proceedings. 33.  0.139
1975 Slotkin TA, Green HO. Adrenal medullary storage vesicles of the spontaneously hypertensive rat Biochemical Pharmacology. 24: 173-180. PMID 234230 DOI: 10.1016/0006-2952(75)90274-9  0.139
1973 Slotkin TA. Maturation of the adrenal medulla-I. Uptake and storage of amines in isolated storage vesicles of the rat Biochemical Pharmacology. 22: 2023-2032. PMID 4726565 DOI: 10.1016/0006-2952(73)90083-X  0.136
2000 Meyer JS, Slotkin TA, Buckley NE, Sircar R. Receptors for abused drugs: development and plasticity. Neurotoxicology and Teratology. 22: 773-84. PMID 11188756 DOI: 10.1016/S0892-0362(00)00103-3  0.135
1996 Slotkin TA, McCook EC, Ritchie JC, Seidler FJ. Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological Psychiatry. 40: 576-84. PMID 8886290 DOI: 10.1016/0006-3223(95)00469-6  0.134
1975 Anderson TR, Slotkin TA. Effects of morphine on the rat adrenal medulla Biochemical Pharmacology. 24: 671-679. PMID 235930 DOI: 10.1016/0006-2952(75)90242-7  0.133
1982 Lau C, Slotkin TA. Stimulation of rat heart ornithine decarboxylase by isoproterenol: Evidence for post-translational control of enzyme activity? European Journal of Pharmacology. 78: 99-105. PMID 7075668 DOI: 10.1016/0014-2999(82)90376-4  0.132
1986 Rosenberg MR, Strom SC, Pachman S, Slotkin TA, Michalopoulos G. Induction of rat kidney ornithine decarboxylase by nicotinamide without a concomitant increase in DNA synthesis. Carcinogenesis. 7: 175-8. PMID 2935321 DOI: 10.1093/Carcin/7.1.175  0.132
1981 Seidler FJ, Slotkin TA. Development of central control of cardiac norepinephrine turnover in the rat heart Federation Proceedings. 40: 82.  0.126
1970 Slotkin TA, DiStefano V, Au WY. Blood levels and urinary excretion of harmine and its metabolites in man and rats Journal of Pharmacology and Experimental Therapeutics. 173: 26-30. PMID 5442301  0.124
1970 Slotkin TA, DiStefano V. A model of harmine metabolism in the rat Journal of Pharmacology and Experimental Therapeutics. 174: 456-462. PMID 5456178  0.124
1973 Slotkin TA. Maturation of the adrenal medulla-II. Content and properties of catecholamine storage vesicles of the rat Biochemical Pharmacology. 22: 2033-2044. PMID 4726566 DOI: 10.1016/0006-2952(73)90084-1  0.123
1976 Slotkin TA, Lau C, Bartolomé M, Seidler FJ. Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles. Life Sciences. 19: 483-91. PMID 957884 DOI: 10.1016/0024-3205(76)90226-5  0.121
1996 Bissette G, Seidler FJ, Nemeroff CB, Slotkin TA. High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy. Annals of the New York Academy of Sciences. 777: 197-204. PMID 8624084 DOI: 10.1111/j.1749-6632.1996.tb34419.x  0.118
1984 Bell JM, Slotkin TA. Effects of dietary phosphatidylcholine (PC) on developmental neurochemistry and sensorimotor behavior Federation Proceedings. 43.  0.116
1981 Slotkin TA, Deskin R, Bartolome J. Effects of hormone and drug treatments on the development of sympathetic nervous system (SNS) cardiac reflex to hypotension Federation Proceedings. 40: 81.  0.112
2009 Slotkin TA, Seidler FJ. Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Environmental Health Perspectives. 117: 587-96. PMID 19440498 DOI: 10.1289/ehp.0800251  0.112
2013 Slotkin TA. Maternal smoking and conduct disorder in the offspring. Jama Psychiatry. 70: 901-2. PMID 23884399 DOI: 10.1001/jamapsychiatry.2013.1951  0.11
2009 Slotkin TA, Seidler FJ, Wu C, MacKillop EA, Linden KG. Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells. Environmental Health Perspectives. 117: 338-43. PMID 19337505 DOI: 10.1289/Ehp.11592  0.107
1983 Slotkin TA, Bartolome J. Ornithine decarboxylase: Marker of neuroendocrine and neurotransmitter actions Methods in Enzymology. 590-603. PMID 6142400  0.106
2011 Powers CM, Badireddy AR, Ryde IT, Seidler FJ, Slotkin TA. Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. Environmental Health Perspectives. 119: 37-44. PMID 20840908 DOI: 10.1289/Ehp.1002337  0.104
1977 Bareis DL, Slotkin TA. Role of the sympathetic system in the response of heart ornithine decarboxylase (ODC) to acute and chronic methadone Federation Proceedings. 36.  0.104
2007 Slotkin TA, MacKillop EA, Ryde IT, Tate CA, Seidler FJ. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. Environmental Health Perspectives. 115: 93-101. PMID 17366826 DOI: 10.1289/ehp.9527  0.103
1974 Slotkin TA. Structure-activity relationships for the reserpine-like actions of derivatives of β-carboline in vitro Life Sciences. 15: 439-454. PMID 4549926 DOI: 10.1016/0024-3205(74)90342-7  0.103
1984 Seidler FJ, Slotkin TA. Adrenomedullary catecholamine (CA) release in the neonatal rat Federation Proceedings. 43.  0.103
1990 Douglas JM, Swain ME, Slotkin TA, Smith PK, Cox JL. Cryosurgical denervation of the heart: Acute and chronic effects The Journal of Thoracic and Cardiovascular Surgery. 100: 198-209. DOI: 10.1016/s0022-5223(19)35559-x  0.102
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