Kivanc birsoy - Publications

Affiliations: 
Whitehead Institute, Cambridge, MA, United States 

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Birsoy K, Sancak Y. The role of metabolism in cellular processes. Molecular Biology of the Cell. 30: 733. PMID 30870095 DOI: 10.1091/mbc.E19-01-0004  0.36
2019 Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K. CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Molecular Cell. PMID 30846317 DOI: 10.1016/j.molcel.2019.01.037  0.76
2019 Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, et al. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nature Medicine. PMID 30842678 DOI: 10.1038/s41591-019-0370-1  0.76
2019 Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, ... Birsoy K, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. PMID 30760928 DOI: 10.1038/s41586-019-0945-5  0.76
2018 Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW. MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 30541894 DOI: 10.1073/pnas.1816656115  0.76
2018 Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. PMID 30089842 DOI: 10.1038/s41556-018-0184-2  0.52
2018 Dubard Gault M, Mandelker D, DeLair D, Stewart CR, Kemel Y, Sheehan MR, Siegel B, Kennedy J, Marcell V, Arnold A, Al-Ahmadie H, Modak S, Robson M, Shukla N, Roberts S, ... ... Birsoy K, et al. Germline mutations in children and adults with cancer. Cold Spring Harbor Molecular Case Studies. 4. PMID 30068732 DOI: 10.1101/mcs.a002584  0.76
2018 Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. PMID 29941933 DOI: 10.1038/s41556-018-0118-z  0.52
2018 Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Molecular Cell. 69: 610-621.e5. PMID 29452640 DOI: 10.1016/j.molcel.2018.01.024  0.76
2017 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. PMID 29168506 DOI: 10.1038/nature24637  0.76
2017 Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nature Chemical Biology. PMID 29058724 DOI: 10.1038/nchembio.2499  0.76
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/pnas.1617922114  0.76
2017 Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, ... ... Birsoy K, et al. Amplification of Adipogenic Commitment by VSTM2A. Cell Reports. 18: 93-106. PMID 28052263 DOI: 10.1016/j.celrep.2016.12.015  0.32
2016 Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM. Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 166: 1324-1337.e11. PMID 27565352 DOI: 10.1016/j.cell.2016.07.040  0.76
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, et al. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. 12: 656. PMID 27434767 DOI: 10.1038/nchembio0816-656  0.76
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. PMID 27110680 DOI: 10.1038/nchembio.2070  0.76
2015 Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science (New York, N.Y.). PMID 26472758 DOI: 10.1126/science.aac7041  0.76
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405]. Molecular Metabolism. 4: 592. PMID 26266092 DOI: 10.1016/j.molmet.2015.05.004  0.76
2015 Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 162: 540-551. PMID 26232224 DOI: 10.1016/j.cell.2015.07.016  0.76
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression. Molecular Metabolism. 4: 392-405. PMID 25973387 DOI: 10.1016/j.molmet.2015.02.002  0.76
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/nature14363  0.76
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405] Molecular Metabolism. DOI: 10.1016/j.molmet.2015.05.004  0.76
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for mTORC1 in erythropoiesis and anemia. Elife. 3: e01913. PMID 25201874 DOI: 10.7554/eLife.01913  0.76
2014 Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM. Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Reports. 7: 27-34. PMID 24685140 DOI: 10.1016/j.celrep.2014.02.046  0.76
2014 Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 508: 108-12. PMID 24670634 DOI: 10.1038/nature13110  0.76
2014 Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery. 4: 554-63. PMID 24631838 DOI: 10.1158/2159-8290.CD-13-0929  0.76
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Lamming DA, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Science Signaling. 7: ra17. PMID 24550542 DOI: 10.1126/scisignal.2004785  0.76
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. A correction to the research article titled: "The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism" (Science Signaling (2014)) Science Signaling. 7. DOI: 10.1126/scisignal.7315er2  0.76
2013 Birsoy K, Festuccia WT, Laplante M. A comparative perspective on lipid storage in animals. Journal of Cell Science. 126: 1541-52. PMID 23658371 DOI: 10.1242/jcs.104992  0.76
2013 Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics. 45: 104-8. PMID 23202129 DOI: 10.1038/ng.2471  0.76
2012 Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 151: 1126-37. PMID 23178128 DOI: 10.1016/j.cell.2012.10.039  0.76
2012 Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metabolism. 16: 202-12. PMID 22883231 DOI: 10.1016/j.cmet.2012.07.008  0.76
2012 Birsoy K, Sabatini DM, Possemato R. Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson. Nature Medicine. 18: 1022-3. PMID 22772555 DOI: 10.1038/nm.2870  0.76
2012 Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 486: 490-5. PMID 22722868 DOI: 10.1038/nature11163  0.76
2012 Ceyhan O, Birsoy K, Hoffman CS. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chemistry & Biology. 19: 155-63. PMID 22284362 DOI: 10.1016/j.chembiol.2011.12.010  0.76
2011 Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development (Cambridge, England). 138: 4709-19. PMID 21989915 DOI: 10.1242/dev.067710  0.76
2011 Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476: 346-50. PMID 21760589 DOI: 10.1038/nature10350  0.76
2010 Chen W, Zhang X, Birsoy K, Roeder RG. A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 10196-201. PMID 20479251 DOI: 10.1073/pnas.1005626107  0.76
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metabolism. 11: 11-22. PMID 20074524 DOI: 10.1016/j.cmet.2009.11.007  0.76
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene (DOI:10.1016/j.cmet.2009.11.007) Cell Metabolism. 11: 239. DOI: 10.1016/j.cmet.2010.02.010  0.76
2008 Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell. 135: 240-9. PMID 18835024 DOI: 10.1016/j.cell.2008.09.036  0.76
2008 Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proceedings of the National Academy of Sciences of the United States of America. 105: 12985-90. PMID 18753616 DOI: 10.1073/pnas.0805621105  0.76
2008 Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metabolism. 7: 339-47. PMID 18396140 DOI: 10.1016/j.cmet.2008.02.001  0.76
2005 Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschläger T. SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5. The Journal of Biological Chemistry. 280: 9937-45. PMID 15637059 DOI: 10.1074/jbc.M414149200  0.76
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