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Simone Eggert, PhD - Publications

Affiliations: 
2011- Human Biology and Human Genetics TU Kaiserslautern 
Area:
Alzheimer's disease, APP as a synaptic adhesion molecule, APP dimerization, APP processing, APP family members APLP1 and APLP2
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S, Eggert S. APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell & Bioscience. 13: 141. PMID 37533067 DOI: 10.1186/s13578-023-01092-6  0.658
2023 Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S, Eggert S. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity. Acta Neuropathologica Communications. 11: 87. PMID 37259128 DOI: 10.1186/s40478-023-01577-y  0.642
2022 Busch L, Eggert S, Endres K, Bufe B. The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease. Cells. 11. PMID 36359817 DOI: 10.3390/cells11213421  0.429
2021 Eggert S, Kins S, Endres K, Brigadski T. Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer's disease. Biological Chemistry. PMID 34619027 DOI: 10.1515/hsz-2021-0330  0.345
2020 Eggert S, Gruebl T, Rajender R, Rupp C, Sander B, Heesch A, Zimmermann M, Hoepfner S, Zentgraf H, Kins S. The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif. Cellular and Molecular Life Sciences : Cmls. PMID 32065241 DOI: 10.1007/s00018-020-03467-1  0.499
2017 Eggert S, Thomas C, Kins S, Hermey G. Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Molecular Neurobiology. PMID 29079999 DOI: 10.1007/s12035-017-0806-x  0.485
2017 Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cellular and Molecular Life Sciences : Cmls. PMID 28799085 DOI: 10.1007/S00018-017-2625-7  0.759
2017 Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S. LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Frontiers in Molecular Neuroscience. 10: 118. PMID 28496400 DOI: 10.3389/fnmol.2017.00118  0.65
2017 Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller U, Kins S, Eggert S. APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28450540 DOI: 10.1523/Jneurosci.1875-16.2017  0.662
2014 Stahl R, Schilling S, Soba P, Rupp C, Hartmann T, Wagner K, Merdes G, Eggert S, Kins S. Shedding of APP limits its synaptogenic activity and cell adhesion properties. Frontiers in Cellular Neuroscience. 8: 410. PMID 25520622 DOI: 10.3389/Fncel.2014.00410  0.755
2014 Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S. Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11159-72. PMID 25122912 DOI: 10.1523/JNEUROSCI.0180-14.2014  0.334
2013 Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15596-602. PMID 24068826 DOI: 10.1523/Jneurosci.5195-12.2013  0.584
2013 Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, Waschbüsch D, Eggert S, Formstecher E, Müthing J, Dreisewerd K, Kins S, Goud B, Barnekow A. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. Plos One. 8: e64149. PMID 23737971 DOI: 10.1371/Journal.Pone.0064149  0.406
2012 Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, Ku L, Eggert S, Hof PR, Koo EH, Dickstein DL. Amyloid precursor protein (APP) regulates synaptic structure and function. Molecular and Cellular Neurosciences. 51: 43-52. PMID 22884903 DOI: 10.1016/J.Mcn.2012.07.009  0.688
2012 Midthune B, Tyan SH, Walsh JJ, Sarsoza F, Eggert S, Hof PR, Dickstein DL, Koo EH. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Molecular and Cellular Neurosciences. 49: 448-55. PMID 22353605 DOI: 10.1016/J.Mcn.2012.02.001  0.756
2012 Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cellular and Molecular Life Sciences : Cmls. 69: 1353-75. PMID 22105709 DOI: 10.1007/S00018-011-0882-4  0.739
2012 Baumkötter F, Wagner K, Eggert S, Wild K, Kins S. Structural aspects and physiological consequences of APP/APLP trans-dimerization. Experimental Brain Research. 217: 389-95. PMID 21952790 DOI: 10.1007/s00221-011-2878-6  0.524
2011 Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, et al. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. The Journal of Biological Chemistry. 286: 39804-12. PMID 21868378 DOI: 10.1074/Jbc.M111.274696  0.668
2010 Walsh JJ, Tyan S, Midthune B, Yu-Jung Shih A, Eggert S, Hof PR, Koo E, Dickstein DL. P1-135: Comparison of neuronal morphology in pyramidal neurons of the CA1, dentate gyrus, and prefrontal cortex of APP knockout and APLP2 knockout mice Alzheimer's & Dementia. 6: S213-S213. DOI: 10.1016/J.Jalz.2010.05.684  0.686
2010 Kukar T, Ladd T, Robertson P, Moore B, Jansen-West K, Eggert S, Koo E, Golde T. O2-03-01: Insight into the mechanism of gamma-secretase cleavage: Juxtamembrane amino acids are key to the length of secreted amyloid beta peptide Alzheimer's & Dementia. 6: S100-S100. DOI: 10.1016/J.Jalz.2010.05.314  0.566
2010 Nagahara AH, Mateling M, Eggert S, Blesch A, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. P3-323: Early BDNF gene delivery into entorhinal cortex in APP transgenic mice ameliorates cells loss and preserves context-dependent fear conditioning Alzheimer's & Dementia. 6: S547-S547. DOI: 10.1016/J.Jalz.2010.05.1824  0.506
2010 Tyan S, Midthune B, Eggert S, Dickstein DL, Koo EH. P2-328: Role of amyloid precursor proteins and beta-amyloid-induced synaptic dysfunction Alzheimer's & Dementia. 6: S409-S409. DOI: 10.1016/J.Jalz.2010.05.1379  0.74
2009 Eggert S, Midthune B, Cottrell B, Koo EH. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. The Journal of Biological Chemistry. 284: 28943-52. PMID 19596858 DOI: 10.1074/Jbc.M109.038646  0.758
2006 Kuan YH, Gruebl T, Soba P, Eggert S, Nesic I, Back S, Kirsch J, Beyreuther K, Kins S. PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2. The Journal of Biological Chemistry. 281: 40114-23. PMID 17050537 DOI: 10.1074/Jbc.M605407200  0.784
2005 Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K. Homo- and heterodimerization of APP family members promotes intercellular adhesion. The Embo Journal. 24: 3624-34. PMID 16193067 DOI: 10.1038/Sj.Emboj.7600824  0.762
2004 Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, Beyreuther K. The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. The Journal of Biological Chemistry. 279: 18146-56. PMID 14970212 DOI: 10.1074/Jbc.M311601200  0.777
2003 Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/Bi027375C  0.632
2002 Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry. 41: 2825-35. PMID 11851430 DOI: 10.1021/Bi015794O  0.597
2000 Reinhard FB, Eggert S, Kreger S, Soba PA, Weidemann A. Analysis of the role of charge residues in the transmembrane domains of presenilin-2 Neurobiology of Aging. 21: 112. DOI: 10.1016/S0197-4580(00)82304-0  0.611
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