Claus U. Pietrzik - Publications

1998-2003 Pathobiochemistry University of Mainz, Germany, Mainz, Rheinland-Pfalz, Germany 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Marques ARA, Di Spiezio A, Thießen N, Schmidt L, Grötzinger J, Lüllmann-Rauch R, Damme M, Storck SE, Pietrzik CU, Fogh J, Bär J, Mikhaylova M, Glatzel M, Bassal M, Bartsch U, et al. Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis. Autophagy. PMID 31282275 DOI: 10.1080/15548627.2019.1637200  0.64
2019 Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, et al. Degradome of soluble ADAM10 and ADAM17 metalloproteases. Cellular and Molecular Life Sciences : Cmls. PMID 31209506 DOI: 10.1007/s00018-019-03184-4  0.44
2019 Van Gool B, Storck SE, Reekmans SM, Lechat B, Gordts PLSM, Pradier L, Pietrzik CU, Roebroek AJM. LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 31004319 DOI: 10.1007/s12035-019-1594-2  0.64
2019 Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C. Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802391R. PMID 30916990 DOI: 10.1096/fj.201802391R  0.44
2018 Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, et al. The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Acta Neuropathologica. PMID 30426203 DOI: 10.1007/s00401-018-1929-5  0.68
2018 Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain, Behavior, and Immunity. PMID 30041013 DOI: 10.1016/j.bbi.2018.07.017  0.68
2018 Goel P, Jumpertz T, Tichá A, Ogorek I, Mikles DC, Hubalek M, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29463448 DOI: 10.1016/j.bmcl.2018.02.017  0.68
2017 Di Spiezio A, Sandin ES, Dore R, Müller-Fielitz H, Storck SE, Bernau M, Mier W, Oster H, Jöhren O, Pietrzik CU, Lehnert H, Schwaninger M. The LepR-mediated leptin transport across brain barriers controls food reward. Molecular Metabolism. PMID 29254602 DOI: 10.1016/j.molmet.2017.12.001  0.64
2017 Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases. Biochemistry. PMID 29185711 DOI: 10.1021/acs.biochem.7b01066  0.68
2017 Storck SE, Pietrzik CU. Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease. Pharmaceutical Research. PMID 28948494 DOI: 10.1007/s11095-017-2267-3  0.64
2017 Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J. Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice. Acta Neuropathologica Communications. 5: 49. PMID 28637503 DOI: 10.1186/s40478-017-0448-2  0.4
2017 Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S. LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Frontiers in Molecular Neuroscience. 10: 118. PMID 28496400 DOI: 10.3389/fnmol.2017.00118  0.64
2016 Becker-Pauly C, Pietrzik CU. The Metalloprotease Meprin β Is an Alternative β-Secretase of APP. Frontiers in Molecular Neuroscience. 9: 159. PMID 28105004 DOI: 10.3389/fnmol.2016.00159  0.44
2016 Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, ... Pietrzik CU, et al. Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28003343 DOI: 10.1096/fj.201601113R  0.44
2016 Becker-Pauly C, Pietrzik CU. Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models. Ebiomedicine. PMID 27396345 DOI: 10.1016/j.ebiom.2016.06.035  0.44
2016 Safina D, Schlitt F, Romeo R, Pflanzner T, Pietrzik CU, Narayanaswami V, Edenhofer F, Faissner A. Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation. Glia. PMID 27258849 DOI: 10.1002/glia.23009  0.76
2016 Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU. Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site. Molecular Neurodegeneration. 11: 19. PMID 26895626 DOI: 10.1186/s13024-016-0084-5  0.76
2015 Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, ... Pietrzik CU, et al. Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. The Journal of Clinical Investigation. PMID 26619118 DOI: 10.1172/JCI81108  0.76
2015 Rabiej VK, Pflanzner T, Wagner T, Götze K, Storck S, Eble JA, Weggen S, Mueller-Klieser W, Pietrzik CU. Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration. Experimental Cell Research. PMID 26610862 DOI: 10.1016/j.yexcr.2015.11.020  0.76
2015 Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C. Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding. The Biochemical Journal. 470: 91-103. PMID 26251449 DOI: 10.1042/BJ20141417  0.44
2015 Meister S, Storck SE, Hameister E, Behl C, Weggen S, Clement AM, Pietrzik CU. Expression of the ALS-causing variant hSOD1(G93A) leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 1112-21. PMID 25853911 DOI: 10.1038/jcbfm.2015.57  0.76
2015 Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C. Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding Biochemical Journal. 470: 91-103. DOI: 10.1042/BJ20141417  0.76
2013 Meister S, Zlatev I, Stab J, Docter D, Baches S, Stauber RH, Deutsch M, Schmidt R, Ropele S, Windisch M, Langer K, Wagner S, von Briesen H, Weggen S, Pietrzik CU. Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood-brain barrier model. Alzheimer's Research & Therapy. 5: 51. PMID 24280275 DOI: 10.1186/alzrt225  0.76
2013 Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, Pietrzik CU. LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Molecular Neurodegeneration. 8: 25. PMID 23866919 DOI: 10.1186/1750-1326-8-25  0.76
2013 Wagner T, Dieckmann M, Jaeger S, Weggen S, Pietrzik CU. Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing. Experimental Cell Research. 319: 1956-72. PMID 23701949 DOI: 10.1016/j.yexcr.2013.05.010  0.76
2013 Gil SY, Youn BS, Byun K, Huang H, Namkoong C, Jang PG, Lee JY, Jo YH, Kang GM, Kim HK, Shin MS, Pietrzik CU, Lee B, Kim YB, Kim MS. Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nature Communications. 4: 1862. PMID 23673647 DOI: 10.1038/ncomms2896  0.76
2013 Jefferson T, Auf Dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, ... Pietrzik CU, et al. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10 Cellular and Molecular Life Sciences. 70: 309-333. PMID 22940918 DOI: 10.1007/s00018-012-1106-2  0.76
2012 Rennhack A, Jumpertz T, Ness J, Baches S, Pietrzik CU, Weggen S, Bulic B. Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells. Bioorganic & Medicinal Chemistry. 20: 6523-32. PMID 23000293 DOI: 10.1016/j.bmc.2012.08.034  0.76
2012 Bien J, Jefferson T, Causević M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. The Journal of Biological Chemistry. 287: 33304-13. PMID 22879596 DOI: 10.1074/jbc.M112.395608  0.76
2012 Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S. Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening. Acs Chemical Biology. 7: 1488-95. PMID 22725102 DOI: 10.1021/cb3001952  0.76
2012 Wagner S, Zensi A, Wien SL, Tschickardt SE, Maier W, Vogel T, Worek F, Pietrzik CU, Kreuter J, von Briesen H. Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model. Plos One. 7: e32568. PMID 22396775 DOI: 10.1371/journal.pone.0032568  0.76
2012 Müller UC, Pietrzik CU, Deller T. The physiological functions of the β-amyloid precursor protein APP. Experimental Brain Research. 217: 325-9. PMID 22349563 DOI: 10.1007/s00221-012-3039-2  0.76
2012 Pflanzner T, Petsch B, André-Dohmen B, Müller-Schiffmann A, Tschickardt S, Weggen S, Stitz L, Korth C, Pietrzik CU. Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 628-32. PMID 22293988 DOI: 10.1038/jcbfm.2012.7  0.76
2012 Jumpertz T, Rennhack A, Ness J, Baches S, Pietrzik CU, Bulic B, Weggen S. Presenilin is the molecular target of acidic γ-secretase modulators in living cells. Plos One. 7: e30484. PMID 22238696 DOI: 10.1371/journal.pone.0030484  0.76
2012 Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cellular and Molecular Life Sciences : Cmls. 69: 1353-75. PMID 22105709 DOI: 10.1007/s00018-011-0882-4  0.76
2012 Wagner T, Pietrzik CU. The role of lipoprotein receptors on the physiological function of APP. Experimental Brain Research. 217: 377-87. PMID 21947084 DOI: 10.1007/s00221-011-2876-8  0.76
2011 Jefferson T, ÄŒauÅ¡ević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. The Journal of Biological Chemistry. 286: 27741-50. PMID 21646356 DOI: 10.1074/jbc.M111.252718  0.76
2011 Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU. Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Current Alzheimer Research. 8: 115-31. PMID 21345168  0.76
2011 Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/s00702-010-0572-7  0.76
2011 Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. Journal of Neurochemistry. 116: 385-95. PMID 21091478 DOI: 10.1111/j.1471-4159.2010.07118.x  0.76
2011 Pflanzner T, Janko MC, André-Dohmen B, Reuss S, Weggen S, Roebroek AJ, Kuhlmann CR, Pietrzik CU. LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier. Neurobiology of Aging. 32: 2323.e1-11. PMID 20630619 DOI: 10.1016/j.neurobiolaging.2010.05.025  0.76
2010 Pflanzner T, Kuhlmann CR, Pietrzik CU. Blood-brain-barrier models for the investigation of transporter- and receptor-mediated amyloid-β clearance in Alzheimer's disease Current Alzheimer Research. 7: 578-590. PMID 20704558  0.76
2010 Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cellular and Molecular Life Sciences : Cmls. 67: 135-45. PMID 19856143 DOI: 10.1007/s00018-009-0171-7  0.76
2009 Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. Journal of Neurochemistry. 111: 1369-82. PMID 19804379 DOI: 10.1111/j.1471-4159.2009.06420.x  0.76
2009 Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik CU, de Curtis M, Luhmann HJ. Mechanisms of C-reactive protein-induced blood-brain barrier disruption. Stroke; a Journal of Cerebral Circulation. 40: 1458-66. PMID 19246692 DOI: 10.1161/STROKEAHA.108.535930  0.76
2009 Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S. Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein. Neuro-Degenerative Diseases. 6: 1-8. PMID 18349521 DOI: 10.1159/000121391  0.76
2008 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/JNEUROSCI.2635-08.2008  0.76
2008 Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, Ghebremedhin E, Thal DR. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. Journal of Neuropathology and Experimental Neurology. 67: 842-56. PMID 18716559 DOI: 10.1097/NEN.0b013e3181836a71  0.76
2008 Waldron E, Heilig C, Schweitzer A, Nadella N, Jaeger S, Martin AM, Weggen S, Brix K, Pietrzik CU. LRP1 modulates APP trafficking along early compartments of the secretory pathway. Neurobiology of Disease. 31: 188-97. PMID 18559293 DOI: 10.1016/j.nbd.2008.04.006  0.76
2008 Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. Experimental Cell Research. 314: 2419-33. PMID 18559276 DOI: 10.1016/j.yexcr.2008.05.003  0.76
2008 Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of Biological Chemistry. 283: 17049-54. PMID 18426795 DOI: 10.1074/jbc.M802912200  0.76
2008 Martin AM, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann HJ, Laatsch A, Weggen S, Lessmann V, Pietrzik CU. The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 283: 12004-13. PMID 18321860 DOI: 10.1074/jbc.M707607200  0.76
2008 Jaeger S, Pietrzik CU. Functional role of lipoprotein receptors in Alzheimer's disease. Current Alzheimer Research. 5: 15-25. PMID 18288927 DOI: 10.2174/156720508783884675  0.76
2007 Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7817-26. PMID 17634375 DOI: 10.1523/JNEUROSCI.1026-07.2007  0.76
2007 Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. The Journal of Biological Chemistry. 282: 24504-13. PMID 17573346 DOI: 10.1074/jbc.M700618200  0.76
2006 Waldron E, Jaeger S, Pietrzik CU. Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 233-8. PMID 17047362 DOI: 10.1159/000095261  0.76
2006 Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. The Journal of Biological Chemistry. 281: 7583-94. PMID 16344553 DOI: 10.1074/jbc.M508340200  0.76
2006 Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/j.1471-4159.2005.03553.x  0.76
2005 Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. The Journal of Biological Chemistry. 280: 27303-9. PMID 15917251 DOI: 10.1074/jbc.M413969200  0.76
2005 Yoon IS, Pietrzik CU, Kang DE, Koo EH. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. The Journal of Biological Chemistry. 280: 20140-7. PMID 15772078 DOI: 10.1074/jbc.M413729200  0.76
2004 Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4259-65. PMID 15115822 DOI: 10.1523/JNEUROSCI.5451-03.2004  0.76
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. The Journal of Biological Chemistry. 278: 31831-7. PMID 12805356 DOI: 10.1074/jbc.M303592200  0.76
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. The Journal of Biological Chemistry. 278: 30748-54. PMID 12777371 DOI: 10.1074/jbc.M304824200  0.76
2002 Pietrzik CU, Busse T, Merriam DE, Weggen S, Koo EH. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. The Embo Journal. 21: 5691-700. PMID 12411487 DOI: 10.1093/emboj/cdf568  0.76
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  0.76
2001 Soriano S, Lu DC, Chandra S, Pietrzik CU, Koo EH. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. The Journal of Biological Chemistry. 276: 29045-50. PMID 11397796 DOI: 10.1074/jbc.M102456200  0.76
2000 Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. The Journal of Clinical Investigation. 106: 1159-66. PMID 11067868 DOI: 10.1172/JCI11013  0.76
1999 Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, Herzog V. Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 47: 373-82. PMID 10026239  0.76
1998 Pietrzik CU, Hoffmann J, Stöber K, Chen CY, Bauer C, Otero DA, Roch JM, Herzog V. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 1770-5. PMID 9465092 DOI: 10.1073/pnas.95.4.1770  0.76
1996 Popp GM, Graebert KS, Pietrzik CU, Rosentreter SM, Lemansky P, Herzog V. Growth regulation of rat thyrocytes (FRTL-5 cells) by the secreted ectodomain of beta-amyloid precursor-like proteins. Endocrinology. 137: 1975-83. PMID 8612538 DOI: 10.1210/endo.137.5.8612538  0.76
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