S. John Mihic, Ph.D. - Publications

Affiliations: 
1997-2000 Wake Forrest 
 2000- University of Texas at Austin, Austin, Texas, U.S.A. 
Area:
ligand gated ion channels

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Cornelison GL, Daszkowski AW, Pflanz NC, Mihic SJ. Interactions between zinc and allosteric modulators of the glycine receptor. The Journal of Pharmacology and Experimental Therapeutics. PMID 28087784 DOI: 10.1124/jpet.116.239152  0.84
2016 Cornelison GL, Pflanz NC, Tipps ME, Mihic SJ. Identification and characterization of heptapeptide modulators of the glycine receptor. European Journal of Pharmacology. PMID 27038522 DOI: 10.1016/j.ejphar.2016.03.058  1
2015 Farley NM, Mihic SJ. Allosteric modulation of the glycine receptor activated by agonists differing in efficacy. Brain Research. 1606: 95-101. PMID 25721789 DOI: 10.1016/j.brainres.2015.02.024  1
2014 Cornelison GL, Mihic SJ. Contaminating levels of zinc found in commonly-used labware and buffers affect glycine receptor currents. Brain Research Bulletin. 100: 1-5. PMID 24177173 DOI: 10.1016/j.brainresbull.2013.10.012  1
2013 Kirson D, Cornelison GL, Philpo AE, Todorovic J, Mihic SJ. Physiological concentrations of zinc reduce taurine-activated GlyR responses to drugs of abuse. Neuropharmacology. 75: 286-94. PMID 23973295 DOI: 10.1016/j.neuropharm.2013.07.025  1
2012 Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI, Harris RA. Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice. Anesthesiology. 117: 765-71. PMID 22885675 DOI: 10.1097/ALN.0b013e31826a0d93  1
2012 Kirson D, Todorovic J, Mihic SJ. Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor. The Journal of Pharmacology and Experimental Therapeutics. 342: 61-70. PMID 22473615 DOI: 10.1124/jpet.112.191486  1
2012 Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. The Journal of Pharmacology and Experimental Therapeutics. 340: 304-16. PMID 22037201 DOI: 10.1124/jpet.111.185116  0.84
2010 Welsh BT, Kirson D, Allen HM, Mihic SJ. Ethanol enhances taurine-activated glycine receptor function. Alcoholism, Clinical and Experimental Research. 34: 1634-9. PMID 20586750 DOI: 10.1111/j.1530-0277.2010.01249.x  1
2010 Tipps ME, Lawshe JE, Ellington AD, Mihic SJ. Identification of novel specific allosteric modulators of the glycine receptor using phage display. The Journal of Biological Chemistry. 285: 22840-5. PMID 20501662 DOI: 10.1074/jbc.M110.130815  1
2010 Todorovic J, Welsh BT, Bertaccini EJ, Trudell JR, Mihic SJ. Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 107: 7987-92. PMID 20385800 DOI: 10.1073/pnas.1001845107  1
2010 McCracken LM, Trudell JR, Goldstein BE, Harris RA, Mihic SJ. Zinc enhances ethanol modulation of the alpha1 glycine receptor. Neuropharmacology. 58: 676-81. PMID 19913039 DOI: 10.1016/j.neuropharm.2009.11.001  1
2009 Welsh BT, Goldstein BE, Mihic SJ. Single-channel analysis of ethanol enhancement of glycine receptor function. The Journal of Pharmacology and Experimental Therapeutics. 330: 198-205. PMID 19380602 DOI: 10.1124/jpet.109.154344  1
2008 Harris RA, Trudell JR, Mihic SJ. Ethanol's molecular targets. Science Signaling. 1: re7. PMID 18632551 DOI: 10.1126/scisignal.128re7  1
2007 Dupre ML, Broyles JM, Mihic SJ. Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation. Brain Research. 1152: 1-9. PMID 17434460 DOI: 10.1016/j.brainres.2007.03.031  1
2006 Roberts MT, Phelan R, Erlichman BS, Pillai RN, Ma L, Lopreato GF, Mihic SJ. Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function. The Journal of Biological Chemistry. 281: 3305-11. PMID 16361257 DOI: 10.1074/jbc.M502000200  1
2004 Davies DL, Crawford DK, Trudell JR, Mihic SJ, Alkana RL. Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. Journal of Neurochemistry. 89: 1175-85. PMID 15147510 DOI: 10.1111/j.1471-4159.2004.02390.x  1
2004 Harris RA, Mihic SJ. Alcohol and inhibitory receptors: unexpected specificity from a nonspecific drug. Proceedings of the National Academy of Sciences of the United States of America. 101: 2-3. PMID 14695895 DOI: 10.1073/pnas.0307281101  1
2003 Lopreato GF, Banerjee P, Mihic SJ. Amino acids in transmembrane domain two influence anesthetic enhancement of serotonin-3A receptor function. Brain Research. Molecular Brain Research. 118: 45-51. PMID 14559353 DOI: 10.1016/S0169-328X(03)00332-2  1
2003 Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, Harris RA. Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8051-9. PMID 12954867  1
2003 Davies DL, Trudell JR, Mihic SJ, Crawford DK, Alkana RL. Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcoholism, Clinical and Experimental Research. 27: 743-55. PMID 12766618 DOI: 10.1097/01.ALC.0000065722.31109.A1  1
2003 Lopreato GF, Phelan R, Borghese CM, Beckstead MJ, Mihic SJ. Inhaled drugs of abuse enhance serotonin-3 receptor function. Drug and Alcohol Dependence. 70: 11-5. PMID 12681521 DOI: 10.1016/S0376-8716(02)00330-7  1
2002 Beckstead MJ, Phelan R, Trudell JR, Bianchini MJ, Mihic SJ. Anesthetic and ethanol effects on spontaneously opening glycine receptor channels. Journal of Neurochemistry. 82: 1343-51. PMID 12354281 DOI: 10.1046/j.1471-4159.2002.01086.x  1
2002 Caraiscos VB, Mihic SJ, MacDonald JF, Orser BA. Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. The Journal of Physiology. 539: 495-502. PMID 11882681 DOI: 10.1113/jphysiol.2001.013508  1
2001 Zhang Y, Stabernack CR, Dutton R, Sonner J, Trudell JR, Mihic SJ, Yamakura T, Harris RA, Gong D, Eger EI. Luciferase as a model for the site of inhaled anesthetic action. Anesthesia and Analgesia. 93: 1246-52. PMID 11682406  1
2001 Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Molecular Genetics and Metabolism. 74: 186-99. PMID 11592815 DOI: 10.1006/mgme.2001.3212  1
2001 Beckstead MJ, Phelan R, Mihic SJ. Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function. The Journal of Biological Chemistry. 276: 24959-64. PMID 11346643 DOI: 10.1074/jbc.M011627200  1
2000 Ueno S, Lin A, Nikolaeva N, Trudell JR, Mihic SJ, Harris RA, Harrison NL. Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. British Journal of Pharmacology. 131: 296-302. PMID 10991923 DOI: 10.1038/sj.bjp.0703504  1
2000 Beckstead MJ, Weiner JL, Eger EI, Gong DH, Mihic SJ. Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse. Molecular Pharmacology. 57: 1199-205. PMID 10825391  1
1999 Yamakura T, Mihic SJ, Harris RA. Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. The Journal of Biological Chemistry. 274: 23006-12. PMID 10438467 DOI: 10.1074/jbc.274.33.23006  1
1999 Mihic SJ. Acute effects of ethanol on GABAA and glycine receptor function. Neurochemistry International. 35: 115-23. PMID 10405995 DOI: 10.1016/S0197-0186(99)00053-4  1
1998 Harris RA, Mihic SJ, Valenzuela CF. Alcohol and benzodiazepines: recent mechanistic studies. Drug and Alcohol Dependence. 51: 155-64. PMID 9716937 DOI: 10.1016/S0376-8716(98)00073-8  1
1998 Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL, Harris RA. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proceedings of the National Academy of Sciences of the United States of America. 95: 6504-9. PMID 9600996 DOI: 10.1073/pnas.95.11.6504  1
1998 Ye Q, Koltchine VV, Mihic SJ, Mascia MP, Wick MJ, Finn SE, Harrison NL, Harris RA. Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. The Journal of Biological Chemistry. 273: 3314-9. PMID 9452448 DOI: 10.1074/jbc.273.6.3314  1
1998 Machu TK, Mihic SJ, Dildy-Mayfield JE. Selective actions of a detergent on ligand-gated ion channels expressed in Xenopus oocytes. The Journal of Pharmacology and Experimental Therapeutics. 284: 32-6. PMID 9435157  1
1997 Mihic SJ, Harris RA. GABA and the GABAA receptor. Alcohol Health and Research World. 21: 127-31. PMID 15704348  1
1997 Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature. 389: 385-9. PMID 9311780 DOI: 10.1038/38738  0.52
1997 Harris RA, Mihic SJ, Brozowski S, Hadingham K, Whiting PJ. Ethanol, flunitrazepam, and pentobarbital modulation of GABAA receptors expressed in mammalian cells and Xenopus oocytes. Alcoholism, Clinical and Experimental Research. 21: 444-51. PMID 9161604  1
1996 Dildy-Mayfield JE, Mihic SJ, Liu Y, Deitrich RA, Harris RA. Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects. British Journal of Pharmacology. 118: 378-84. PMID 8735641  1
1996 Mihic SJ, Harris RA. Robotic automation of Xenopus oocyte bath perfusion. Biotechniques. 20: 802-4. PMID 8723922  1
1996 Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, Harris RA. A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Molecular Pharmacology. 50: 402-6. PMID 8700149  1
1996 Mihic SJ, Harris RA. Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics. The Journal of Pharmacology and Experimental Therapeutics. 277: 411-6. PMID 8613949  1
1995 Mihic SJ, Sanna E, Whiting PJ, Harris RA. Pharmacology of recombinant GABAA receptors. Advances in Biochemical Psychopharmacology. 48: 17-40. PMID 7653324  1
1995 Harris RA, Mihic SJ, Dildy-Mayfield JE, Machu TK. Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 1454-62. PMID 7589987  1
1994 Francis J, Mihic SJ, Sneddon WB, Burnham WM. The effect of anticonvulsant drugs on GABA-stimulated chloride uptake. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 21: 3-8. PMID 8180901 DOI: 10.1017/S031716710004868X  1
1994 Mihic SJ, Whatley VJ, McQuilkin SJ, Harris RA. beta-Lumicolchicine interacts with the benzodiazepine binding site to potentiate GABAA receptor-mediated currents. Journal of Neurochemistry. 62: 1790-4. PMID 8158128  1
1994 Mihic SJ, McQuilkin SJ, Eger EI, Ionescu P, Harris RA. Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Molecular Pharmacology. 46: 851-7. PMID 7969071  1
1994 Mihic SJ, Whiting PJ, Harris RA. Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity. European Journal of Pharmacology. 268: 209-14. PMID 7957642 DOI: 10.1016/0922-4106(94)90190-2  1
1994 Whatley VJ, Mihic SJ, Allan AM, McQuilkin SJ, Harris RA. Gamma-aminobutyric acidA receptor function is inhibited by microtubule depolymerization. The Journal of Biological Chemistry. 269: 19546-52. PMID 7913471  1
1994 Mihic SJ, Whiting PJ, Klein RL, Wafford KA, Harris RA. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. The Journal of Biological Chemistry. 269: 32768-73. PMID 7806498  1
1993 Wu PH, Mihic SJ, Liu JF, Lê AD, Kalant H. Blockade of chronic tolerance to ethanol by the NMDA antagonist, (+)-MK-801. European Journal of Pharmacology. 231: 157-64. PMID 8453972 DOI: 10.1016/0014-2999(93)90444-M  0.64
1993 Mihic SJ, van Berckel BN, Wu PH, Kalant H. GABA and pentobarbital potentiation of chloride influx into microsacs is influenced by incubation time. Brain Research. 619: 319-23. PMID 8374787 DOI: 10.1016/0006-8993(93)91627-5  1
1992 Mihic SJ, Wu PH, Kalant H. Potentiation of gamma-aminobutyric acid-mediated chloride flux by pentobarbital and diazepam but not ethanol. Journal of Neurochemistry. 58: 745-51. PMID 1729416  1
1992 Khanna JM, Mihic SJ, Weiner J, Shah G, Wu PH, Kalant H. Differential inhibition by NMDA antagonists of rapid tolerance to, and cross-tolerance between, ethanol and chlordiazepoxide. Brain Research. 574: 251-6. PMID 1638398 DOI: 10.1016/0006-8993(92)90824-S  1
1992 Wu PH, Liu JF, Mihic SJ, Kalant H. Arginine-8-vasopressin potentiates acute ethanol intoxication. Pharmacology, Biochemistry, and Behavior. 41: 409-14. PMID 1574531 DOI: 10.1016/0091-3057(92)90119-Z  1
1992 Mihic SJ, Kalant H, Liu JF, Wu PH. Role of the gamma-aminobutyric acid receptor/chloride channel complex in tolerance to ethanol and cross-tolerance to diazepam and pentobarbital. The Journal of Pharmacology and Experimental Therapeutics. 261: 108-13. PMID 1373188  1
1992 Mihic SJ, Van Berckel BN, O'Dowd BF, Nguyen T, Wu PH. Effects of sedatives on GABA-mediated chloride flux into cerebral cortical microsacs prepared from emotional and non-emotional mice. European Journal of Pharmacology. 218: 283-6. PMID 1330599 DOI: 10.1016/0014-2999(92)90180-C  1
1991 Mihic SJ, Wu PH, Kalant H. Differences among effects of sedative-hypnotic drugs on GABA-mediated chloride flux: quench flow studies. Brain Research. 555: 259-64. PMID 1933338 DOI: 10.1016/0006-8993(91)90350-5  1
1991 Marchese A, Mihic SJ, Wu PH, Kalant H. Arginine8-vasopressin potentiates the motor incoordinating effects of pentobarbital. European Journal of Pharmacology. 202: 341-5. PMID 1748156 DOI: 10.1016/0014-2999(91)90276-V  1
1988 Mihic SJ, Wu PH, Kalant H. Buffer systems variably affect the interaction of norepinephrine with brain Na+-K+ ATPase. Canadian Journal of Physiology and Pharmacology. 66: 1035-40. PMID 2846134  1
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