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James Trudell - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Anesthesia
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Borghese CM, Wang HL, McHardy SF, Messing RO, Trudell JR, Harris RA, Bertaccini EJ. Modulation of α1β3γ2 GABA receptors expressed in oocytes using a propofol photoswitch tethered to the transmembrane helix. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33593898 DOI: 10.1073/pnas.2008178118  0.302
2020 Popova M, Rodriguez L, Trudell JR, Nguyen S, Bloomfield M, Davies DL, Asatryan L. Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity. International Journal of Molecular Sciences. 21. PMID 32252459 DOI: 10.3390/Ijms21072471  0.398
2018 Pflanz NC, Daszkowski AW, Cornelison GL, Trudell JR, Mihic SJ. An intersubunit electrostatic interaction in the GABA receptor facilitates its responses to benzodiazepines. The Journal of Biological Chemistry. 293: 8264-8274. PMID 29622679 DOI: 10.1074/jbc.RA118.002128  0.319
2015 Borghese CM, Ruiz CI, Lee US, Cullins MA, Bertaccini EJ, Trudell JR, Harris RA. Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors. Acs Chemical Neuroscience. PMID 26571107 DOI: 10.1021/Acschemneuro.5B00246  0.373
2015 Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ. Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors. Alcoholism, Clinical and Experimental Research. 39: 962-8. PMID 25973519 DOI: 10.1111/Acer.12735  0.418
2014 Bertaccini EJ, Dickinson R, Trudell JR, Franks NP. Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics. Acs Chemical Neuroscience. 5: 1246-52. PMID 25340635 DOI: 10.1021/cn500172e  0.32
2014 Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL. Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. Molecular Pharmacology. 86: 635-46. PMID 25245406 DOI: 10.1124/Mol.114.093773  0.405
2014 Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL. P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Frontiers in Neuroscience. 8: 176. PMID 25009459 DOI: 10.3389/Fnins.2014.00176  0.327
2014 Trudell JR, Messing RO, Mayfield J, Harris RA. Alcohol dependence: molecular and behavioral evidence. Trends in Pharmacological Sciences. 35: 317-23. PMID 24865944 DOI: 10.1016/J.Tips.2014.04.009  0.326
2014 Howard RJ, Trudell JR, Harris RA. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacological Reviews. 66: 396-412. PMID 24515646 DOI: 10.1124/Pr.113.007468  0.322
2014 Asatryan L, Yardley MM, Khoja S, Trudell JR, Hyunh N, Louie SG, Petasis NA, Alkana RL, Davies DL. Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 907-16. PMID 24451653 DOI: 10.1017/S1461145713001703  0.37
2014 Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcoholism, Clinical and Experimental Research. 38: 595-603. PMID 24164436 DOI: 10.1111/Acer.12283  0.427
2014 Borghese CM, Hicks JA, Lapid DJ, Trudell JR, Harris RA. GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites. Journal of Neurochemistry. 128: 363-75. PMID 24117469 DOI: 10.1111/Jnc.12476  0.333
2014 Riederer E, Yoluk O, Trudell J, Lindahl E, Harris A, Howard R. Alcohol Modulation of a Eukaryotic Ligand-Gated Ion Channel of Known Structure Biophysical Journal. 106: 545a. DOI: 10.1016/J.Bpj.2013.11.3034  0.401
2013 Yoluk O, Brömstrup T, Bertaccini EJ, Trudell JR, Lindahl E. Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin. Biophysical Journal. 105: 640-7. PMID 23931312 DOI: 10.1016/J.Bpj.2013.06.037  0.357
2013 McCracken LM, Trudell JR, McCracken ML, Harris RA. Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol. Alcoholism, Clinical and Experimental Research. 37: 2002-10. PMID 23895467 DOI: 10.1111/Acer.12192  0.367
2013 Popova M, Trudell J, Li K, Alkana R, Davies D, Asatryan L. Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors. Purinergic Signalling. 9: 621-32. PMID 23817978 DOI: 10.1007/S11302-013-9373-4  0.367
2013 Bertaccini EJ, Yoluk O, Lindahl ER, Trudell JR. Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor. Anesthesiology. 119: 1087-95. PMID 23770602 DOI: 10.1097/ALN.0b013e31829e47e3  0.322
2013 McCracken LM, Blednov YA, Trudell JR, Benavidez JM, Betz H, Harris RA. Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. The Journal of Pharmacology and Experimental Therapeutics. 344: 489-500. PMID 23230213 DOI: 10.1124/Jpet.112.197707  0.369
2012 Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E. Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. Plos Computational Biology. 8: e1002710. PMID 23055913 DOI: 10.1371/Journal.Pcbi.1002710  0.446
2012 Perkins DI, Trudell JR, Asatryan L, Davies DL, Alkana RL. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. The Journal of Pharmacology and Experimental Therapeutics. 341: 543-51. PMID 22357974 DOI: 10.1124/Jpet.111.190942  0.377
2012 Johnson WD, Howard RJ, Trudell JR, Harris RA. The TM2 6' position of GABA(A) receptors mediates alcohol inhibition. The Journal of Pharmacology and Experimental Therapeutics. 340: 445-56. PMID 22072732 DOI: 10.1124/Jpet.111.188037  0.333
2012 Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. The Journal of Pharmacology and Experimental Therapeutics. 340: 304-16. PMID 22037201 DOI: 10.1124/Jpet.111.185116  0.386
2012 Xu M, Smothers CT, Trudell J, Woodward JJ. Ethanol inhibition of constitutively open N-methyl-D-aspartate receptors. The Journal of Pharmacology and Experimental Therapeutics. 340: 218-26. PMID 22005043 DOI: 10.1124/jpet.111.187179  0.404
2011 Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA. Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 12149-54. PMID 21730162 DOI: 10.1073/Pnas.1104480108  0.368
2011 Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcoholism, Clinical and Experimental Research. 35: 1561-73. PMID 21676006 DOI: 10.1111/J.1530-0277.2011.01502.X  0.357
2011 Murail S, Wallner B, Trudell JR, Bertaccini E, Lindahl E. Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor. Biophysical Journal. 100: 1642-50. PMID 21463577 DOI: 10.1016/J.Bpj.2011.02.032  0.442
2010 Bertaccini EJ, Wallner B, Trudell JR, Lindahl E. Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. Journal of Chemical Information and Modeling. 50: 2248-55. PMID 21117677 DOI: 10.1021/Ci100266C  0.36
2010 McCracken ML, Borghese CM, Trudell JR, Harris RA. A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics. The Journal of Pharmacology and Experimental Therapeutics. 335: 600-6. PMID 20826568 DOI: 10.1124/Jpet.110.170472  0.387
2010 Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL. Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. The Journal of Pharmacology and Experimental Therapeutics. 334: 720-8. PMID 20543096 DOI: 10.1124/jpet.110.167908  0.378
2010 Perkins DI, Trudell JR, Crawford DK, Alkana RL, Davies DL. Molecular targets and mechanisms for ethanol action in glycine receptors. Pharmacology & Therapeutics. 127: 53-65. PMID 20399807 DOI: 10.1016/J.Pharmthera.2010.03.003  0.343
2010 Todorovic J, Welsh BT, Bertaccini EJ, Trudell JR, Mihic SJ. Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 107: 7987-92. PMID 20385800 DOI: 10.1073/Pnas.1001845107  0.338
2010 McCracken LM, Trudell JR, Goldstein BE, Harris RA, Mihic SJ. Zinc enhances ethanol modulation of the alpha1 glycine receptor. Neuropharmacology. 58: 676-81. PMID 19913039 DOI: 10.1016/J.Neuropharm.2009.11.001  0.388
2009 Perkins DI, Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL. Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. The Journal of Biological Chemistry. 284: 27304-14. PMID 19656948 DOI: 10.1074/Jbc.M109.023598  0.381
2008 Crawford DK, Perkins DI, Trudell JR, Bertaccini EJ, Davies DL, Alkana RL. Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. The Journal of Biological Chemistry. 283: 27698-706. PMID 18658152 DOI: 10.1074/Jbc.M802384200  0.318
2008 Jenkins A, Lobo IA, Gong D, Trudell JR, Solt K, Harris RA, Eger EI. General anesthetics have additive actions on three ligand gated ion channels. Anesthesia and Analgesia. 107: 486-93. PMID 18633027 DOI: 10.1213/Ane.0B013E31817B70C1  0.374
2008 Harris RA, Trudell JR, Mihic SJ. Ethanol's molecular targets. Science Signaling. 1: re7. PMID 18632551 DOI: 10.1126/Scisignal.128Re7  0.34
2008 Perkins DI, Trudell JR, Crawford DK, Alkana RL, Davies DL. Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. Journal of Neurochemistry. 106: 1337-49. PMID 18485105 DOI: 10.1111/J.1471-4159.2008.05476.X  0.326
2008 Lobo IA, Harris RA, Trudell JR. Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. Journal of Neurochemistry. 104: 1649-62. PMID 18036150 DOI: 10.1111/J.1471-4159.2007.05090.X  0.38
2007 Crawford DK, Trudell JR, Bertaccini EJ, Li K, Davies DL, Alkana RL. Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors. Journal of Neurochemistry. 102: 2097-109. PMID 17561937 DOI: 10.1111/J.1471-4159.2007.04680.X  0.371
2006 Lobo IA, Trudell JR, Harris RA. Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharmacology. 50: 174-81. PMID 16225893 DOI: 10.1016/J.Neuropharm.2005.08.017  0.361
2005 Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends in Pharmacological Sciences. 26: 503-10. PMID 16126282 DOI: 10.1016/J.Tips.2005.08.006  0.316
2005 Bertaccini EJ, Shapiro J, Brutlag DL, Trudell JR. Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site. Journal of Chemical Information and Modeling. 45: 128-35. PMID 15667138 DOI: 10.1021/Ci0497399  0.366
2004 Kash TL, Kim T, Trudell JR, Harrison NL. Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neuroscience Letters. 371: 230-4. PMID 15519763 DOI: 10.1016/j.neulet.2004.09.002  0.385
2004 Lobo IA, Trudell JR, Harris RA. Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. Journal of Neurochemistry. 90: 962-9. PMID 15287902 DOI: 10.1111/J.1471-4159.2004.02561.X  0.365
2004 Schofield CM, Trudell JR, Harrison NL. Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry. 43: 10058-63. PMID 15287733 DOI: 10.1021/Bi036159G  0.365
2004 Lobo IA, Mascia MP, Trudell JR, Harris RA. Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. The Journal of Biological Chemistry. 279: 33919-27. PMID 15169788 DOI: 10.1074/Jbc.M313941200  0.356
2004 Davies DL, Crawford DK, Trudell JR, Mihic SJ, Alkana RL. Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. Journal of Neurochemistry. 89: 1175-85. PMID 15147510 DOI: 10.1111/J.1471-4159.2004.02390.X  0.303
2004 Castaldo P, Stefanoni P, Miceli F, Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL, Annunziato L, Taglialatela M. A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. The Journal of Biological Chemistry. 279: 25598-604. PMID 15066993 DOI: 10.1074/jbc.M311021200  0.361
2004 Kash TL, Dizon MJ, Trudell JR, Harrison NL. Charged residues in the beta2 subunit involved in GABAA receptor activation. The Journal of Biological Chemistry. 279: 4887-93. PMID 14610076 DOI: 10.1074/jbc.M311441200  0.335
2003 Borghese CM, Henderson LA, Bleck V, Trudell JR, Harris RA. Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors. The Journal of Pharmacology and Experimental Therapeutics. 307: 42-52. PMID 14500778 DOI: 10.1124/Jpet.102.053710  0.307
2003 Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesthesia and Analgesia. 97: 718-40. PMID 12933393 DOI: 10.1213/01.Ane.0000081063.76651.33  0.361
2003 Arias HR, Trudell JR, Bayer EZ, Hester B, McCardy EA, Blanton MP. Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives. Biochemistry. 42: 7358-70. PMID 12809491 DOI: 10.1021/bi034052n  0.311
2003 Arias HR, Kem WR, Trudell JR, Blanton MP. Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor. International Review of Neurobiology. 54: 1-50. PMID 12785284 DOI: 10.1016/S0074-7742(03)54002-8  0.33
2003 Davies DL, Trudell JR, Mihic SJ, Crawford DK, Alkana RL. Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcoholism, Clinical and Experimental Research. 27: 743-55. PMID 12766618 DOI: 10.1097/01.Alc.0000065722.31109.A1  0.346
2003 Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL. Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature. 421: 272-5. PMID 12529644 DOI: 10.1038/nature01280  0.361
2002 Jenkins A, Andreasen A, Trudell JR, Harrison NL. Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology. 43: 669-78. PMID 12367612 DOI: 10.1016/S0028-3908(02)00175-2  0.31
2002 Beckstead MJ, Phelan R, Trudell JR, Bianchini MJ, Mihic SJ. Anesthetic and ethanol effects on spontaneously opening glycine receptor channels. Journal of Neurochemistry. 82: 1343-51. PMID 12354281 DOI: 10.1046/j.1471-4159.2002.01086.x  0.475
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