Year |
Citation |
Score |
2023 |
Futai E, Kawasaki H, Sato S, Daoudi K, Hidaka M, Tomita T, Ogawa T. A Metalloproteinase Cocktail from the Venom of Cleaves Amyloid Beta Peptides at the α-Cleavage Site. Toxins. 15. PMID 37624257 DOI: 10.3390/toxins15080500 |
0.318 |
|
2023 |
Tomizawa I, Chiu YW, Hori Y, Tomita T. [Identification of novel regulators involved in AD pathogenesis using the CRISPR-Cas9 system]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 158: 21-25. PMID 36596482 DOI: 10.1254/fpj.22081 |
0.303 |
|
2022 |
Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. Iscience. 25: 103869. PMID 35243232 DOI: 10.1016/j.isci.2022.103869 |
0.673 |
|
2022 |
Islam S, Sun Y, Gao Y, Nakamura T, Noorani AA, Li T, Wong PC, Kimura N, Matsubara E, Kasuga K, Ikeuchi T, Tomita T, Zou K, Michikawa M. Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34987110 DOI: 10.1523/JNEUROSCI.2039-21.2021 |
0.328 |
|
2021 |
Cai T, Tomita T. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation. Journal of Biochemistry. PMID 33739423 DOI: 10.1093/jb/mvab033 |
0.351 |
|
2020 |
Chiu YW, Hori Y, Ebinuma I, Sato H, Hara N, Ikeuchi T, Tomita T. Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9-based screening system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32307772 DOI: 10.1096/fj.201902966RR |
0.424 |
|
2020 |
Cai T, Tomita T. Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage. Seminars in Cell & Developmental Biology. PMID 32171519 DOI: 10.1016/j.semcdb.2020.02.006 |
0.439 |
|
2019 |
Cai T, Hatano A, Kanatsu K, Tomita T. Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH. Journal of Biochemistry. PMID 31816046 DOI: 10.1093/jb/mvz110 |
0.402 |
|
2019 |
Cai T, Morishima K, Takagi-Niidome S, Tominaga A, Tomita T. Conformational dynamics of transmembrane domain 3 of presenilin 1 is associated with the trimming activity of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31527118 DOI: 10.1523/JNEUROSCI.0838-19.2019 |
0.438 |
|
2019 |
Furusawa K, Takasugi T, Chiu YW, Hori Y, Tomita T, Fukuda M, Hisanaga SI. CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway. The Journal of Biological Chemistry. PMID 31138646 DOI: 10.1074/jbc.RA118.005385 |
0.43 |
|
2019 |
Suzuki T, Hori Y, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T. Photo-oxygenation inhibits tau amyloid formation. Chemical Communications (Cambridge, England). PMID 31049495 DOI: 10.1039/c9cc01728c |
0.381 |
|
2019 |
Brummer T, Müller SA, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, Endres K, Lichtenthaler SF. NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease. Embo Molecular Medicine. PMID 30833305 DOI: 10.15252/emmm.201809695 |
0.419 |
|
2019 |
Takatori S, Wang W, Iguchi A, Tomita T. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in Experimental Medicine and Biology. 1118: 83-116. PMID 30747419 DOI: 10.1007/978-3-030-05542-4_5 |
0.38 |
|
2019 |
Tomita T, Ozawa S, Sohma Y, Kanai M, Hori Y. P2-059: PHOTOOXYGENATION BY BIOCOMPATIBLE CATALYST REDUCES THE Aβ LEVEL IN THE BRAINS OF ALZHEIMER DISEASE MODEL MICE Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2466 |
0.307 |
|
2018 |
Imai S, Cai T, Yoshida C, Tomita T, Futai E. Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid beta trimming. Journal of Biochemistry. PMID 30289529 DOI: 10.1093/jb/mvy081 |
0.434 |
|
2018 |
Kanatsu K, Hori Y, Ebinuma I, Chiu YW, Tomita T. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production. Journal of Neurochemistry. PMID 29851073 DOI: 10.1111/jnc.14477 |
0.425 |
|
2018 |
Takatori S, Tomita T. AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease. Advances in Experimental Medicine and Biology. PMID 29774507 DOI: 10.1007/5584_2018_218 |
0.376 |
|
2018 |
Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Doré V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, et al. High performance plasma amyloid-β biomarkers for Alzheimer's disease. Nature. 554: 249-254. PMID 29420472 DOI: 10.1038/Nature25456 |
0.325 |
|
2018 |
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184 |
0.533 |
|
2018 |
Kaneko N, Matsuzaki M, Yoshizawa Y, Iwamoto S, Tanaka K, Tomita T. P1-200: ANALYSIS OF THE AMYLOID β-RELATED PEPTIDES IN MOUSE PLASMA AND CELL CULTURE MEDIA Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.204 |
0.301 |
|
2018 |
Ni J, Taniguchi A, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido TC, Tomita T, Sohma Y, Kanai M. Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide Chem. 4: 807-820. DOI: 10.1016/J.Chempr.2018.02.008 |
0.386 |
|
2017 |
Cai T, Yonaga M, Tomita T. Activation of γ-secretase trimming activity by topological changes of transmembrane domain 1 of presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29118109 DOI: 10.1523/JNEUROSCI.1628-17.2017 |
0.449 |
|
2017 |
Ito K, Makino M, Okado K, Tomita T. Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochemical and Biophysical Research Communications. PMID 28917837 DOI: 10.1016/j.bbrc.2017.09.058 |
0.378 |
|
2017 |
Liu CY, Ohki Y, Tomita T, Osawa S, Reed BR, Jagust W, Berlo VV, Jin LW, Chui HC, Coppola G, Ringman JM. Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28550247 DOI: 10.3233/JAD-161203 |
0.413 |
|
2017 |
Kikuchi K, Kidana K, Tatebe T, Tomita T. Dysregulated metabolism of the amyloid-β protein and therapeutic approaches in Alzheimer disease. Journal of Cellular Biochemistry. PMID 28488760 DOI: 10.1002/jcb.26129 |
0.388 |
|
2017 |
Sakurai S, Tomita T, Shimizu T, Ohto U. The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif. Acta Crystallographica. Section F, Structural Biology Communications. 73: 130-137. PMID 28291748 DOI: 10.1107/S2053230X17001911 |
0.34 |
|
2017 |
Ito K, Tatebe T, Suzuki K, Hirayama T, Hayakawa M, Kubo H, Tomita T, Makino M. Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking. European Journal of Pharmacology. PMID 28167259 DOI: 10.1016/j.ejphar.2017.02.001 |
0.402 |
|
2017 |
Tomita T. Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease. Advances in Biological Regulation. PMID 28082052 DOI: 10.1016/j.jbior.2017.01.001 |
0.401 |
|
2017 |
Tomita T. Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method Methods in Enzymology. 584: 185-205. PMID 28065263 DOI: 10.1016/Bs.Mie.2016.10.033 |
0.386 |
|
2017 |
Tomita T, Ebinuma I, Tsuruya N, Hori Y. Genomewide Screening Of Molecules Involved In Uptake Of Alzheimer Disease-Associated Proteins By Cripsr/Cas9 System Alzheimers & Dementia. 13: 996. DOI: 10.1016/J.Jalz.2017.06.1374 |
0.311 |
|
2016 |
Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T. Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo. Human Molecular Genetics. PMID 27466196 DOI: 10.1093/hmg/ddw239 |
0.563 |
|
2016 |
Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S. Cell-free methods to produce structurally intact mammalian membrane proteins. Scientific Reports. 6: 30442. PMID 27465719 DOI: 10.1038/srep30442 |
0.301 |
|
2016 |
Kanatsu K, Tomita T. Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer disease. Biological Chemistry. PMID 27390881 DOI: 10.1515/hsz-2016-0146 |
0.415 |
|
2016 |
Reinhardt S, Grimm MO, Stahlmann C, Hartmann T, Shudo K, Tomita T, Endres K. Rescue of Hypovitaminosis A induces non-amyloidogenic Amyloid Precursor Protein (APP) Processing. Current Alzheimer Research. PMID 27335034 DOI: 10.2174/1567205013666160603002105 |
0.378 |
|
2016 |
Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human Molecular Genetics. PMID 27179792 DOI: 10.1093/Hmg/Ddw146 |
0.571 |
|
2016 |
Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/Srep23969 |
0.635 |
|
2016 |
Ueda N, Tomita T, Yanagisawa K, Kimura N. Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance. Journal of Neurochemistry. PMID 26896628 DOI: 10.1111/jnc.13586 |
0.432 |
|
2016 |
Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1362-72. PMID 26818522 DOI: 10.1523/JNEUROSCI.5090-14.2016 |
0.576 |
|
2016 |
Ito K, Tatebe T, Suzuki K, Tomita T, Makino M. P4-072: The Inhibitory Effect of Memantine on the Production of Abeta Peptides Alzheimer's & Dementia. 12: P1041-P1041. DOI: 10.1016/j.jalz.2016.06.2162 |
0.337 |
|
2016 |
Kanatsu K, Hori Y, Takatori S, Tomita T. Partial Loss Of Picalm Predominantly Affects The Amyloid-Beta Deposition In The Piriform Cortex Of Mouse Model Of Alzheimer Disease Alzheimers & Dementia. 12: 1030. DOI: 10.1016/J.Jalz.2016.06.2130 |
0.36 |
|
2015 |
Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T. Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities. The Journal of Biological Chemistry. PMID 26559975 DOI: 10.1074/jbc.M114.629287 |
0.391 |
|
2015 |
Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T. Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2646-56. PMID 25673856 DOI: 10.1523/JNEUROSCI.3164-14.2015 |
0.537 |
|
2015 |
Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T. Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity. Biochemical and Biophysical Research Communications. 457: 194-9. PMID 25545059 DOI: 10.1016/j.bbrc.2014.12.087 |
0.565 |
|
2015 |
Tomita T, Kidana K, Tatebe T, Ouchi Y, Akishita M, Iwatsubo T. Pathophysiological impact of astrocyte-derived kallikrein-related peptidase 7 on Aβ metabolism in brain Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.594 |
0.444 |
|
2014 |
Tomita T. Molecular mechanism of intramembrane proteolysis by γ-secretase. Journal of Biochemistry. 156: 195-201. PMID 25108625 DOI: 10.1093/jb/mvu049 |
0.41 |
|
2014 |
Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, ... ... Tomita T, et al. Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America. 111: 10544-9. PMID 25009180 DOI: 10.1073/Pnas.1402171111 |
0.537 |
|
2014 |
Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T. New photocleavable linker: α-thioacetophenone-type linker. Bioorganic & Medicinal Chemistry Letters. 24: 2831-3. PMID 24841630 DOI: 10.1016/J.Bmcl.2014.04.104 |
0.454 |
|
2014 |
Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T. Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nature Communications. 5: 3386. PMID 24577224 DOI: 10.1038/ncomms4386 |
0.566 |
|
2014 |
Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Molecular Neurodegeneration. 9: 7. PMID 24410857 DOI: 10.1186/1750-1326-9-7 |
0.568 |
|
2014 |
Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M. Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation. Angewandte Chemie (International Ed. in English). 53: 1382-5. PMID 24339209 DOI: 10.1002/anie.201308001 |
0.515 |
|
2014 |
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/J.Str.2013.09.018 |
0.51 |
|
2014 |
Miyagawa T, Morohashi Y, Ojima R, Tsuji S, Iwatsubo T, Tomita T. Bin1 Regulates Bace1 Trafficking And Ab Production Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.314 |
0.435 |
|
2014 |
Tomita T, Tominaga A, Takagi-Niidome S, Iwatsubo T. Conformational Changes In The Transmembrane Domains 4 And 5 Of Presenilin 1 Associated With Altered Abeta42 Production Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.1113 |
0.507 |
|
2013 |
Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956 |
0.599 |
|
2013 |
Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T. Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. Bmc Biochemistry. 14: 16. PMID 23829174 DOI: 10.1186/1471-2091-14-16 |
0.517 |
|
2013 |
Morohashi Y, Tomita T. Protein trafficking and maturation regulate intramembrane proteolysis. Biochimica Et Biophysica Acta. 1828: 2855-61. PMID 23770323 DOI: 10.1016/j.bbamem.2013.06.001 |
0.323 |
|
2013 |
Toyn JH, Rowley A, Matsuoka Y, Tomita T, Imbimbo BP. γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease? International Journal of Alzheimer's Disease. 2013: 849128. PMID 23710414 DOI: 10.1155/2013/849128 |
0.39 |
|
2013 |
Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. Plos One. 8: e64050. PMID 23667698 DOI: 10.1371/journal.pone.0064050 |
0.551 |
|
2013 |
Tomita T, Iwatsubo T. Structural biology of presenilins and signal peptide peptidases. The Journal of Biological Chemistry. 288: 14673-80. PMID 23585568 DOI: 10.1074/jbc.R113.463281 |
0.534 |
|
2013 |
Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T. Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition. Journal of Medicinal Chemistry. 56: 1443-54. PMID 23342950 DOI: 10.1021/Jm301306C |
0.535 |
|
2013 |
Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T. Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry. 52: 61-9. PMID 23210549 DOI: 10.1021/bi301252r |
0.547 |
|
2013 |
Takasugi N, Sasaki T, Tomita T, Iwatsubo T. FTY720/Fingolimod, a sphingosine analogue, reduces beta-amyloid production in neurons Alzheimers & Dementia. 9: 184. DOI: 10.1016/J.Jalz.2013.05.311 |
0.555 |
|
2013 |
Tomita T, Suzuki K, Shiohara A, Osawa S, Iwatsubo T. Pathophysiological role of proteolytic cleavage of neuroligins Alzheimers & Dementia. 9: 144. DOI: 10.1016/J.Jalz.2013.04.097 |
0.444 |
|
2012 |
Tomita T. [Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity]. Rinshō Shinkeigaku = Clinical Neurology. 52: 1165-7. PMID 23196551 DOI: DN/JST.JSTAGE/clinicalneurol/52.1165 |
0.419 |
|
2012 |
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, ... ... Tomita T, et al. Activity-dependent proteolytic cleavage of neuroligin-1. Neuron. 76: 410-22. PMID 23083742 DOI: 10.1016/J.Neuron.2012.10.003 |
0.479 |
|
2012 |
Takeo K, Watanabe N, Tomita T, Iwatsubo T. Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein. The Journal of Biological Chemistry. 287: 25834-43. PMID 22689582 DOI: 10.1074/jbc.M111.336347 |
0.549 |
|
2012 |
Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 31: 787-98. PMID 21725355 DOI: 10.1038/Onc.2011.265 |
0.516 |
|
2012 |
Tomita T, Morohashi Y, Kanatsu K, Iwatsubo T. PICALM regulates Aβ42 production by modulation of gamma-secretase trafficking Alzheimers & Dementia. 8: 312. DOI: 10.1016/J.Jalz.2012.05.857 |
0.515 |
|
2011 |
Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. The Journal of Biological Chemistry. 286: 44569-75. PMID 22074918 DOI: 10.1074/jbc.M111.270108 |
0.528 |
|
2011 |
Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The Embo Journal. 30: 4815-24. PMID 22002539 DOI: 10.1038/Emboj.2011.372 |
0.554 |
|
2011 |
Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T. Three-dimensional structure of the signal peptide peptidase. The Journal of Biological Chemistry. 286: 26188-97. PMID 21636854 DOI: 10.1074/jbc.M111.260273 |
0.513 |
|
2011 |
Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1016/J.Jalz.2011.05.1193 |
0.521 |
|
2011 |
Tomita T, Wong PC. Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's Research & Therapy. 3: 7. PMID 21418547 DOI: 10.1186/Alzrt66 |
0.421 |
|
2010 |
Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15943-50. PMID 21106832 DOI: 10.1523/JNEUROSCI.3318-10.2010 |
0.694 |
|
2010 |
Morohashi Y, Tomita T, Iwatsubo T. [Molecular targeted therapy in Alzheimer disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 68: 1906-10. PMID 20954338 |
0.493 |
|
2010 |
Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503 |
0.538 |
|
2010 |
Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66. PMID 20720123 DOI: 10.1523/JNEUROSCI.2884-10.2010 |
0.556 |
|
2010 |
Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H. Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. Bioorganic & Medicinal Chemistry Letters. 20: 5282-5. PMID 20650635 DOI: 10.1016/j.bmcl.2010.06.131 |
0.463 |
|
2010 |
Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. The Journal of Biological Chemistry. 285: 19738-46. PMID 20418378 DOI: 10.1074/jbc.M110.101287 |
0.58 |
|
2010 |
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Corrigendum to "Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" [Bioorg. Med. Chem. Lett. 19 (2009) 6869] (DOI:10.1016/j.bmcl.2009.10.086) Bioorganic and Medicinal Chemistry Letters. 20: 1798-1799. DOI: 10.1016/J.Bmcl.2010.01.025 |
0.39 |
|
2009 |
Tomita T. [Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity]. Rinshō Shinkeigaku = Clinical Neurology. 49: 845-7. PMID 20030227 DOI: 10.5692/clinicalneurol.49.845 |
0.456 |
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2009 |
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorganic & Medicinal Chemistry Letters. 19: 6869-71. PMID 19892551 DOI: 10.1016/J.Bmcl.2009.10.086 |
0.472 |
|
2009 |
Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Science. 100: 2444-50. PMID 19775286 DOI: 10.1111/j.1349-7006.2009.01328.x |
0.443 |
|
2009 |
Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/Jbc.M109.055061 |
0.573 |
|
2009 |
Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. Journal of the American Chemical Society. 131: 7353-9. PMID 19432477 DOI: 10.1021/ja9001458 |
0.57 |
|
2009 |
Tomita T. Secretase inhibitors and modulators for Alzheimer's disease treatment. Expert Review of Neurotherapeutics. 9: 661-79. PMID 19402777 DOI: 10.1586/ern.09.24 |
0.443 |
|
2009 |
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/Jbc.M806380200 |
0.586 |
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2009 |
Tomita T, Hayashi I, Takatori S, Urano Y, Iwanari H, Kodama T, Hamakubo T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the γ-secretase activity Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.225 |
0.457 |
|
2009 |
Takatori S, Hayashi I, Urano Y, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Intrabody against immature nicastrin disrupts the proper folding and the glycosyl maturation of the extracellular domain of nicastrin Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.504 |
0.475 |
|
2009 |
Miyashita H, Maruyama Y, Ogura T, Mio K, Iwatsubo T, Tomita T, Sato C. Three dimensional structure of signal peptide peptidase Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.503 |
0.45 |
|
2008 |
Tomita T. [Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease]. Rinshō Shinkeigaku = Clinical Neurology. 48: 907-9. PMID 19198114 DOI: 10.5692/Clinicalneurol.48.907 |
0.49 |
|
2008 |
Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL. Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 23: 996-1001. PMID 18608784 DOI: 10.1080/14756360701832706 |
0.527 |
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2008 |
Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/J.Neuron.2008.04.015 |
0.486 |
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2008 |
Sato C, Takagi S, Tomita T, Iwatsubo T. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6264-71. PMID 18550769 DOI: 10.1523/JNEUROSCI.1163-08.2008 |
0.69 |
|
2008 |
Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell & Melanoma Research. 21: 70-8. PMID 18353145 DOI: 10.1111/j.1755-148X.2007.00423.x |
0.452 |
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2008 |
Tomita T. At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 295-300. PMID 18038124 DOI: 10.1007/s00210-007-0206-2 |
0.478 |
|
2008 |
Tomita T. Peptides inhibiting specific cleaving activities of presenilins Expert Opinion On Therapeutic Patents. 18: 1097-1100. DOI: 10.1517/13543776.18.9.1097 |
0.413 |
|
2008 |
Tomita T, Sato C, Takagi S, Iwatsubo T. O4-03-03: C-terminal PAL motif of presenilin 1 comprises the subsite of gamma-secretase within the catalytic pore Alzheimer's & Dementia. 4: T189-T189. DOI: 10.1016/j.jalz.2008.05.520 |
0.624 |
|
2008 |
Watanabe N, Tomita T, Iwatsubo T. P4-211: The functional roles of transmembrane domains of presenilin 1 in the formation of active gamma-secretase complex Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2279 |
0.524 |
|
2008 |
Takagi S, Sato C, Tomita T, Iwatsubo T. P4-208: Transmembrane domain 1 of presenilin 1 contributes to the formation of the catalytic pore of gamma-secretase Alzheimer's & Dementia. 4: T732-T732. DOI: 10.1016/j.jalz.2008.05.2276 |
0.647 |
|
2008 |
Sugimoto Y, Fuwa H, Yokoshima S, Fukuyama T, Sasaki M, Tomita T, Iwatsubo T. P4-207: Chemical biological analysis of gamma-secretase using arylsulfonamide-type inhibitors Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2275 |
0.466 |
|
2008 |
Takasugi N, Suzuki K, Isshiki H, Tomita T, Iwatsubo T. P3-348: Neuron-specific regulation of beta-secretase activity by sphingosine kinase Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1917 |
0.467 |
|
2007 |
Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. Acs Chemical Biology. 2: 408-18. PMID 17530731 DOI: 10.1021/Cb700073Y |
0.51 |
|
2007 |
Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Organic Letters. 9: 2055-8. PMID 17480083 DOI: 10.1021/Ol070376I |
0.466 |
|
2007 |
Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. The Journal of Biological Chemistry. 282: 12388-96. PMID 17329245 DOI: 10.1074/jbc.M611549200 |
0.709 |
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2007 |
Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Photoaffinity Probes for Alzheimer’s Disease Synfacts. 2007: 995-995. DOI: 10.1055/S-2007-968915 |
0.357 |
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2007 |
Hayashi Y, Tomita T, Kopan R, Iwatsubo T. The role of Notch signaling in synaptogenesis Neuroscience Research. 58. DOI: 10.1016/J.Neures.2007.06.863 |
0.589 |
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2006 |
Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 52: 831-43. PMID 17145504 DOI: 10.1016/J.Neuron.2006.10.035 |
0.645 |
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2006 |
Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12081-8. PMID 17108181 DOI: 10.1523/JNEUROSCI.3614-06.2006 |
0.686 |
|
2006 |
Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochemical and Biophysical Research Communications. 351: 57-63. PMID 17054906 DOI: 10.1016/j.bbrc.2006.09.162 |
0.51 |
|
2006 |
Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration. 1: 2. PMID 16930449 DOI: 10.1186/1750-1326-1-2 |
0.573 |
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2006 |
Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quéléver G, Iwatsubo T, Kraus JL. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays. Journal of Medicinal Chemistry. 49: 4275-85. PMID 16821787 DOI: 10.1021/jm0602864 |
0.512 |
|
2006 |
Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 4184-9. PMID 16766183 DOI: 10.1016/J.Bmcl.2006.05.091 |
0.465 |
|
2006 |
Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T. Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters. 16: 3813-6. PMID 16682195 DOI: 10.1016/J.Bmcl.2006.04.025 |
0.459 |
|
2006 |
Keller PC, Tomita T, Hayashi I, Chandu D, Weber JD, Cistola DP, Kopan R. A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry. 45: 5351-8. PMID 16618124 DOI: 10.1021/Bi052228A |
0.768 |
|
2006 |
Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of Biological Chemistry. 281: 14670-6. PMID 16569643 DOI: 10.1074/Jbc.M513012200 |
0.679 |
|
2006 |
Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158 |
0.685 |
|
2006 |
Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental Neuroscience. 28: 102-17. PMID 16508308 DOI: 10.1159/000090757 |
0.517 |
|
2006 |
Tomita T, Iwatsubo T. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current Pharmaceutical Design. 12: 661-70. PMID 16472155 DOI: 10.2174/138161206775474206 |
0.591 |
|
2006 |
Tomita T, Takahashi Y, Fuwa H, Konno Y, Morohashi Y, Kan T, Sugimoto Y, Fukuyama T, Sasaki M, Natsugari H, Iwatsubo T. O1-02-07 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.259 |
0.482 |
|
2006 |
Sato C, Watanabe N, Morohashi Y, Tomita T, Iwatsubo T. P3-416: Probing the structural changes of presenilin 1 by substituted-cysteine accessibility method Alzheimer's & Dementia. 2: S498-S498. DOI: 10.1016/j.jalz.2006.05.1687 |
0.59 |
|
2006 |
Hayashi I, Urano Y, Iwanari H, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. P3-412: Generation of monoclonal antibodies against the extracellular domain of nicastrin Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1683 |
0.428 |
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2006 |
Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025 |
0.605 |
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2006 |
Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M. Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates Heterocycles. 70: 101-106. DOI: 10.1002/CHIN.200722128 |
0.41 |
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2005 |
Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. The Journal of Biological Chemistry. 280: 41967-75. PMID 16234244 DOI: 10.1074/jbc.M509066200 |
0.682 |
|
2005 |
Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, ... ... Tomita T, et al. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2069-71. PMID 16204356 DOI: 10.1096/Fj.05-3744Fje |
0.451 |
|
2005 |
Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma-secretase complex with lipid rafts. Journal of Lipid Research. 46: 904-12. PMID 15716592 DOI: 10.1194/jlr.M400333-JLR200 |
0.57 |
|
2005 |
Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. The Journal of Biological Chemistry. 280: 12967-75. PMID 15644323 DOI: 10.1074/jbc.M409829200 |
0.561 |
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2004 |
Tomita T, Iwatsubo T. [Recent advances in Alzheimer's disease-related gamma-secretase complex]. Seikagaku. the Journal of Japanese Biochemical Society. 76: 666-70. PMID 15346905 |
0.447 |
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2004 |
Tomita T, Iwatsubo T. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease. Drug News & Perspectives. 17: 321-5. PMID 15334182 DOI: 10.1358/dnp.2004.17.5.829036 |
0.578 |
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2004 |
Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. The Journal of Biological Chemistry. 279: 38040-6. PMID 15215237 DOI: 10.1074/jbc.M405597200 |
0.55 |
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2004 |
Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice. The European Journal of Neuroscience. 19: 2826-38. PMID 15147316 DOI: 10.1111/j.0953-816X.2004.03397.x |
0.54 |
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2004 |
Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity. Bioorganic & Medicinal Chemistry Letters. 14: 1983-5. PMID 15050642 DOI: 10.1016/J.Bmcl.2004.01.067 |
0.433 |
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2004 |
Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Molecular and Cellular Biology. 24: 2012-24. PMID 14966281 DOI: 10.1128/MCB.24.5.2012-2024.2004 |
0.446 |
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2004 |
Fukumoto H, Kosaka T, Sagayama M, Kawamoto M, Tomita T, Terauchi J, Tarui N, Kakihana M, Iwatsubo T, Miyamoto M. P4-376 TAK-070, a non-peptidic bace inhibitor inhibits secretion of amyloid beta 40/42 and enhances sappalpha production in neuronal cell cultures Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81934-1 |
0.515 |
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2004 |
Morohashi Y, Tominari Y, Watanabe N, Kan T, Fuwa H, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. P4-322 Presenilin-1 is a molecular target of a dipeptidic γ-secretase inhibitor, DAPT Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81880-3 |
0.455 |
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2004 |
Tomita T, Niimura M, Hayashi I, Sato C, Tanaka S, Shinohara M, Takahashi Y, Morohashi Y, Iwatsubo T. O3-05-04 Roles of presenilin cofactors in the assembly and activity of {gamma}-secretase complex Neurobiology of Aging. 25: S62. DOI: 10.1016/S0197-4580(04)80209-4 |
0.627 |
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2004 |
Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H. Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues Tetrahedron Letters. 45: 2323-2326. DOI: 10.1016/J.Tetlet.2004.01.087 |
0.427 |
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2003 |
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100 |
0.794 |
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2003 |
Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I. Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8513-25. PMID 13679420 DOI: 10.1523/Jneurosci.23-24-08513.2003 |
0.502 |
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2003 |
Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chemical Communications (Cambridge, England). 2244-5. PMID 13678222 DOI: 10.1039/B306970B |
0.408 |
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2003 |
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7 |
0.531 |
|
2003 |
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 422: 438-41. PMID 12660785 DOI: 10.1038/Nature01506 |
0.585 |
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2003 |
Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. The Journal of Biological Chemistry. 278: 18664-70. PMID 12637581 DOI: 10.1074/Jbc.M301619200 |
0.58 |
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2003 |
Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298 |
0.462 |
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2002 |
Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546 |
0.556 |
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2002 |
Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. The Journal of Biological Chemistry. 277: 50198-205. PMID 12388554 DOI: 10.1074/jbc.M205352200 |
0.573 |
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2002 |
Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/Emboj/Cdf541 |
0.606 |
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2002 |
Tomita T, Katayama R, Takikawa R, Iwatsubo T. Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. Febs Letters. 520: 117-21. PMID 12044882 DOI: 10.1016/S0014-5793(02)02802-8 |
0.524 |
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2002 |
Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. The Journal of Biological Chemistry. 277: 14965-75. PMID 11847232 DOI: 10.1074/jbc.M200897200 |
0.529 |
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2001 |
Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200 |
0.711 |
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2001 |
Iwata H, Tomita T, Maruyama K, Iwatsubo T. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2. The Journal of Biological Chemistry. 276: 21678-85. PMID 11283011 DOI: 10.1074/jbc.M007989200 |
0.564 |
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2001 |
Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/Jbc.M008511200 |
0.499 |
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2001 |
Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Biochemical and Biophysical Research Communications. 282: 96-102. PMID 11263977 DOI: 10.1006/bbrc.2001.4558 |
0.46 |
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2000 |
Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2 |
0.58 |
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2000 |
Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, et al. Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Annals of Neurology. 48: 806-8. PMID 11079548 DOI: 10.1002/1531-8249(200011)48:5<806::Aid-Ana18>3.0.Co;2-F |
0.382 |
|
2000 |
Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. The Journal of Biological Chemistry. 275: 17136-42. PMID 10748144 DOI: 10.1074/Jbc.M909624199 |
0.592 |
|
2000 |
Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. International Journal of Molecular Medicine. 5: 269-73. PMID 10677567 DOI: 10.3892/Ijmm.5.3.269 |
0.489 |
|
2000 |
Leem JY, Saura C, Tomita T, Iwatsubo T, Thinakaran G. Structural domain requirements for presenilin endoproteolysis and Aβ42 overproduction Neurobiology of Aging. 21: 261. DOI: 10.1016/S0197-4580(00)83129-2 |
0.512 |
|
2000 |
Kamenetz F, Borchelt DR, Tomita T, Iwatsubo T, Sisodia S, Malinow R. Aβ as a homeostatic negative regulator of synaptic function? Neurobiology of Aging. 21: 76-77. DOI: 10.1016/S0197-4580(00)82567-1 |
0.457 |
|
2000 |
Iwatsubo T, Tomita T, Takikawa R, Watabiki T, Morohashi Y, Takasugi N. Structure-function analysis of presenilins Neurobiology of Aging. 21: 140. DOI: 10.1016/S0197-4580(00)82428-8 |
0.433 |
|
2000 |
Tomita T, Takasugi N, Takikawa R, Watabiki T, Yauchi M, Iwatsubo T. The integrity of carboxyl terminus of presenilin 2 is essential for its functions Neurobiology of Aging. 21: 110-111. DOI: 10.1016/S0197-4580(00)82295-2 |
0.436 |
|
1999 |
Tomita T, Iwatsubo T. [Molecular cell biology of presenilins]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 114: 337-46. PMID 10672594 DOI: 10.1254/Fpj.114.337 |
0.57 |
|
1999 |
Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10627-34. PMID 10594046 |
0.513 |
|
1999 |
Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T. Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42. Neuroreport. 10: 2965-9. PMID 10549806 DOI: 10.1097/00001756-199909290-00017 |
0.485 |
|
1999 |
Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H. Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans. Neuroscience Letters. 273: 203-7. PMID 10515194 DOI: 10.1016/S0304-3940(99)00644-8 |
0.504 |
|
1999 |
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... Tomita T, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669 |
0.717 |
|
1999 |
Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease. Neuroscience Letters. 265: 61-3. PMID 10327206 DOI: 10.1016/S0304-3940(99)00187-1 |
0.569 |
|
1999 |
Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing Journal of Biological Chemistry. 274: 13818-13823. PMID 10318786 DOI: 10.1074/Jbc.274.20.13818 |
0.558 |
|
1999 |
Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C Terminus of Presenilin Is Required for Overproduction of Amyloidogenic Aβ42 through Stabilization and Endoproteolysis of Presenilin The Journal of Neuroscience. 19: 10627-10634. DOI: 10.1523/Jneurosci.19-24-10627.1999 |
0.568 |
|
1999 |
Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 Upregulation Activates β-Secretase–Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer’s Disease The Journal of Neuroscience. 19: 6538-6548. DOI: 10.1523/Jneurosci.19-15-06538.1999 |
0.558 |
|
1998 |
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6 |
0.512 |
|
1998 |
Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K. The presenilin 2 loop domain interacts with the mu-calpain C-terminal region. International Journal of Molecular Medicine. 1: 797-9. PMID 9852298 DOI: 10.3892/Ijmm.1.5.797 |
0.545 |
|
1998 |
Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Annals of Neurology. 44: 415-22. PMID 9749615 DOI: 10.1002/Ana.410440324 |
0.442 |
|
1998 |
Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. The Journal of Biological Chemistry. 273: 21153-60. PMID 9694871 DOI: 10.1074/Jbc.273.33.21153 |
0.72 |
|
1998 |
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X |
0.619 |
|
1998 |
Tomita T, Chang TY, Kodama T, Iwatsubo T. βAPP γ-secretase and SREBP site 2 protease are two different enzymes Neuroreport. 9: 911-913. PMID 9579689 DOI: 10.1097/00001756-199803300-00027 |
0.551 |
|
1998 |
Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells. Biochemical and Biophysical Research Communications. 244: 751-5. PMID 9535737 DOI: 10.1006/bbrc.1998.8336 |
0.485 |
|
1998 |
Iwatsubo T, Baba M, Nakaio S, Tu P-, Tomita T, Nakaya K, -Y. Lee VM, Trojanowski JQ. α-SYNUCLEIN IS A COMPONENT OF LEWY BODIES Journal of Neuropathology and Experimental Neurology. 57: 509. DOI: 10.1097/00005072-199805000-00179 |
0.309 |
|
1997 |
Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898 DOI: 10.1073/Pnas.94.5.2025 |
0.551 |
|
1996 |
Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K. Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43). Biochemical and Biophysical Research Communications. 227: 730-5. PMID 8886002 DOI: 10.1006/bbrc.1996.1577 |
0.532 |
|
1996 |
Kume H, Maruyama K, Tomita T, Iwatsubo T, Saido TC, Obata K. Molecular cloning of a novel basic helix-loop-helix protein from the rat brain. Biochemical and Biophysical Research Communications. 219: 526-30. PMID 8605021 DOI: 10.1006/bbrc.1996.0267 |
0.477 |
|
1996 |
Maruyama K, Tomita T, Ishiura S, Kume H, Kuzume H, Asada H, Kawamura Y, Kanbara N, Saido TC, Iwatsubo T, Obata K. 399 The familial Alzheimer disease-linked mutations of Val717 of amyloid precursor protein is specific for the increased secretion of the longer Aβ Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80401-5 |
0.542 |
|
1996 |
Tomita T, Maruyama K, Saido T, Hosoda R, Tokuhiro S, Kume H, Kuzume H, Asada H, Kawamura Y, Iwatsubo T, Obata K. 59 Characterization of presenilins overexpressed in culture cells Neurobiology of Aging. 17: S15. DOI: 10.1016/S0197-4580(96)80061-3 |
0.421 |
|
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