Taisuke Tomita - Publications

Affiliations: 
The University of Tokyo 
Area:
Alzheimer's disease

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Imai S, Cai T, Yoshida C, Tomita T, Futai E. Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid beta trimming. Journal of Biochemistry. PMID 30289529 DOI: 10.1093/jb/mvy081  0.48
2018 Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184  1
2017 Cai T, Yonaga M, Tomita T. Activation of γ-secretase trimming activity by topological changes of transmembrane domain 1 of presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29118109 DOI: 10.1523/JNEUROSCI.1628-17.2017  0.48
2017 Liu CY, Ohki Y, Tomita T, Osawa S, Reed BR, Jagust W, Berlo VV, Jin LW, Chui HC, Coppola G, Ringman JM. Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28550247 DOI: 10.3233/JAD-161203  0.68
2016 Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T. Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo. Human Molecular Genetics. PMID 27466196 DOI: 10.1093/hmg/ddw239  1
2016 Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S. Cell-free methods to produce structurally intact mammalian membrane proteins. Scientific Reports. 6: 30442. PMID 27465719 DOI: 10.1038/srep30442  1
2016 Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human Molecular Genetics. PMID 27179792 DOI: 10.1093/hmg/ddw146  1
2016 Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/srep23969  1
2016 Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1362-72. PMID 26818522 DOI: 10.1523/JNEUROSCI.5090-14.2016  1
2016 Nakajima S, Tomita T, Taie S, Ichinose T, Ozawa H, Wang L, Troyer M, Takahashi Y. Topological Thouless pumping of ultracold fermions Nature Physics. DOI: 10.1038/nphys3622  0.36
2015 Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T. Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities. The Journal of Biological Chemistry. PMID 26559975 DOI: 10.1074/jbc.M114.629287  1
2015 Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T. Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2646-56. PMID 25673856 DOI: 10.1523/JNEUROSCI.3164-14.2015  1
2015 Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T. Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity. Biochemical and Biophysical Research Communications. 457: 194-9. PMID 25545059 DOI: 10.1016/j.bbrc.2014.12.087  1
2015 Gotou M, Arakawa T, Watanabe N, Hara T, Tomita T, Hashimoto A, Takanashi H, Koiwa I. Molybdenum source for increase of molybdenum content in electrodeposited Cu-Mo composites Bulletin of the Chemical Society of Japan. 88: 173-175. DOI: 10.1246/bcsj.20140225  0.76
2015 Arimoto Y, Higashi N, Igarashi Y, Iwashita Y, Ino T, Katayama R, Kitaguchi M, Kitahara R, Matsumura H, Mishima K, Nagakura N, Oide H, Otono H, Sakakibara R, Shima T, ... ... Tomita T, et al. Development of time projection chamber for precise neutron lifetime measurement using pulsed cold neutron beams Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 799: 187-196. DOI: 10.1016/j.nima.2015.08.006  0.4
2015 Hosoda S, Nonaka M, Tomita T, Taguchi B, Tomita H, Iwasaka N. Impact of downward heat penetration below the shallow seasonal thermocline on the sea surface temperature Journal of Oceanography. DOI: 10.1007/s10872-015-0275-7  0.48
2014 Tomita T. Molecular mechanism of intramembrane proteolysis by γ-secretase. Journal of Biochemistry. 156: 195-201. PMID 25108625 DOI: 10.1093/jb/mvu049  1
2014 Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, ... ... Tomita T, et al. Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America. 111: 10544-9. PMID 25009180 DOI: 10.1073/pnas.1402171111  1
2014 Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T. New photocleavable linker: α-thioacetophenone-type linker. Bioorganic & Medicinal Chemistry Letters. 24: 2831-3. PMID 24841630 DOI: 10.1016/j.bmcl.2014.04.104  1
2014 Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K. Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 5986-91. PMID 24711412 DOI: 10.1073/pnas.1401671111  1
2014 Tomita T. [Modulation of intramembrane proteolysis and its biological function]. Seikagaku. the Journal of Japanese Biochemical Society. 86: 28-40. PMID 24693696  1
2014 Miura T, Miyashita Y, Motoki H, Shimada K, Kobayashi M, Nakajima H, Kimura H, Akanuma H, Mawatari E, Sato T, Hotta S, Kamiyoshi Y, Maruyama T, Watanabe N, Eisawa T, ... ... Tomita T, et al. In-hospital clinical outcomes of elderly patients (≥80 years) undergoing percutaneous coronary intervention. Circulation Journal : Official Journal of the Japanese Circulation Society. 78: 1097-103. PMID 24662401 DOI: DN/JST.JSTAGE/circj/CJ-14-0129  0.76
2014 Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T. Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nature Communications. 5: 3386. PMID 24577224 DOI: 10.1038/ncomms4386  1
2014 Tomita T, Tanaka S, Sato K, Nakaya K. Pectoral fin of the megamouth shark: skeletal and muscular systems, skin histology, and functional morphology. Plos One. 9: e86205. PMID 24465959 DOI: 10.1371/journal.pone.0086205  0.44
2014 Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Molecular Neurodegeneration. 9: 7. PMID 24410857 DOI: 10.1186/1750-1326-9-7  1
2014 Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M. Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation. Angewandte Chemie (International Ed. in English). 53: 1382-5. PMID 24339209 DOI: 10.1002/anie.201308001  1
2014 Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/j.str.2013.09.018  1
2014 Gotou M, Arakawa T, Watanabe N, Hara T, Tomita T, Hashimoto A, Takanashi H, Koiwa I. Codeposition of copper and molybdenum by electroplating Ecs Electrochemistry Letters. 3: D19-D21. DOI: 10.1149/2.013406eel  0.76
2014 Gotou M, Arakawa T, Watanabe N, Hara T, Tomita T, Hashimoto A, Takanashi H, Koiwa I. Copper-molybdenum source ratio and complexing agent for high molybdenum content in electrodeposited cu-mo Journal of the Electrochemical Society. 161: D628-D631. DOI: 10.1149/2.0051412jes  0.76
2013 Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956  1
2013 Tanaka K, Shiina T, Tomita T, Suzuki S, Hosomichi K, Sano K, Doi H, Kono A, Komiyama T, Inoko H, Kulski JK, Tanaka S. Evolutionary relations of Hexanchiformes deep-sea sharks elucidated by whole mitochondrial genome sequences. Biomed Research International. 2013: 147064. PMID 24089661 DOI: 10.1155/2013/147064  0.44
2013 Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T. Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. Bmc Biochemistry. 14: 16. PMID 23829174 DOI: 10.1186/1471-2091-14-16  1
2013 Morohashi Y, Tomita T. Protein trafficking and maturation regulate intramembrane proteolysis. Biochimica Et Biophysica Acta. 1828: 2855-61. PMID 23770323 DOI: 10.1016/j.bbamem.2013.06.001  1
2013 Toyn JH, Rowley A, Matsuoka Y, Tomita T, Imbimbo BP. γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease? International Journal of Alzheimer's Disease. 2013: 849128. PMID 23710414 DOI: 10.1155/2013/849128  1
2013 Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. Plos One. 8: e64050. PMID 23667698 DOI: 10.1371/journal.pone.0064050  1
2013 Tomita T, Iwatsubo T. Structural biology of presenilins and signal peptide peptidases. The Journal of Biological Chemistry. 288: 14673-80. PMID 23585568 DOI: 10.1074/jbc.R113.463281  1
2013 Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T. Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition. Journal of Medicinal Chemistry. 56: 1443-54. PMID 23342950 DOI: 10.1021/jm301306c  1
2013 Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T. Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry. 52: 61-9. PMID 23210549 DOI: 10.1021/bi301252r  1
2012 Tomita T. [Understanding the structure-and-function relationships of gamma-secretase toward the modulation of intramembrane-cleaving activity]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 70: 321-5. PMID 23513859  1
2012 Tomita T. [Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity]. Rinshō Shinkeigaku = Clinical Neurology. 52: 1165-7. PMID 23196551 DOI: DN/JST.JSTAGE/clinicalneurol/52.1165  1
2012 Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, ... ... Tomita T, et al. Activity-dependent proteolytic cleavage of neuroligin-1. Neuron. 76: 410-22. PMID 23083742 DOI: 10.1016/j.neuron.2012.10.003  1
2012 Takeo K, Watanabe N, Tomita T, Iwatsubo T. Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein. The Journal of Biological Chemistry. 287: 25834-43. PMID 22689582 DOI: 10.1074/jbc.M111.336347  1
2012 Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 31: 787-98. PMID 21725355 DOI: 10.1038/onc.2011.265  1
2011 Tomita T. [Presenilin gene]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 69: 98-102. PMID 22787762  1
2011 Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. The Journal of Biological Chemistry. 286: 44569-75. PMID 22074918 DOI: 10.1074/jbc.M111.270108  1
2011 Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The Embo Journal. 30: 4815-24. PMID 22002539 DOI: 10.1038/emboj.2011.372  1
2011 Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T. Three-dimensional structure of the signal peptide peptidase. The Journal of Biological Chemistry. 286: 26188-97. PMID 21636854 DOI: 10.1074/jbc.M111.260273  1
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1523/JNEUROSCI.6467-10.2011  1
2011 Tomita T, Wong PC. Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's Research & Therapy. 3: 7. PMID 21418547 DOI: 10.1186/alzrt66  1
2011 Tomita T, Sakurai Y, Ishibashi S, Maru Y. Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis. Oncogene. 30: 3429-39. PMID 21399660 DOI: 10.1038/onc.2011.53  1
2010 Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15943-50. PMID 21106832 DOI: 10.1523/JNEUROSCI.3318-10.2010  1
2010 Morohashi Y, Tomita T, Iwatsubo T. [Molecular targeted therapy in Alzheimer disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 68: 1906-10. PMID 20954338  1
2010 Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503  1
2010 Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66. PMID 20720123 DOI: 10.1523/JNEUROSCI.2884-10.2010  1
2010 Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H. Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. Bioorganic & Medicinal Chemistry Letters. 20: 5282-5. PMID 20650635 DOI: 10.1016/j.bmcl.2010.06.131  1
2010 Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. The Journal of Biological Chemistry. 285: 19738-46. PMID 20418378 DOI: 10.1074/jbc.M110.101287  1
2010 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Corrigendum to "Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" [Bioorg. Med. Chem. Lett. 19 (2009) 6869] (DOI:10.1016/j.bmcl.2009.10.086) Bioorganic and Medicinal Chemistry Letters. 20: 1798-1799. DOI: 10.1016/j.bmcl.2010.01.025  1
2009 Tomita T. [Structure and function analysis of gamma-secretase complex toward development of therapeutics for Alzheimer's disease]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 54: 1684-9. PMID 21089607  1
2009 Tomita T. [Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity]. Rinshō Shinkeigaku = Clinical Neurology. 49: 845-7. PMID 20030227 DOI: 10.5692/clinicalneurol.49.845  1
2009 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorganic & Medicinal Chemistry Letters. 19: 6869-71. PMID 19892551 DOI: 10.1016/j.bmcl.2009.10.086  1
2009 Tomita T. [Biology and pathobiology of the intramembrane proteolysis by gamma-secretase]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 54: 1747-53. PMID 19827607  1
2009 Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Science. 100: 2444-50. PMID 19775286 DOI: 10.1111/j.1349-7006.2009.01328.x  1
2009 Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/jbc.M109.055061  1
2009 Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. Journal of the American Chemical Society. 131: 7353-9. PMID 19432477 DOI: 10.1021/ja9001458  1
2009 Tomita T. Secretase inhibitors and modulators for Alzheimer's disease treatment. Expert Review of Neurotherapeutics. 9: 661-79. PMID 19402777 DOI: 10.1586/ern.09.24  1
2009 Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/jbc.M806380200  1
2008 Tomita T. [Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease]. Rinshō Shinkeigaku = Clinical Neurology. 48: 907-9. PMID 19198114  1
2008 Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL. Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 23: 996-1001. PMID 18608784 DOI: 10.1080/14756360701832706  1
2008 Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/j.neuron.2008.04.015  1
2008 Sato C, Takagi S, Tomita T, Iwatsubo T. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6264-71. PMID 18550769 DOI: 10.1523/JNEUROSCI.1163-08.2008  1
2008 Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell & Melanoma Research. 21: 70-8. PMID 18353145 DOI: 10.1111/j.1755-148X.2007.00423.x  1
2008 Tomita T. At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 295-300. PMID 18038124 DOI: 10.1007/s00210-007-0206-2  1
2008 Tomita T. Peptides inhibiting specific cleaving activities of presenilins Expert Opinion On Therapeutic Patents. 18: 1097-1100. DOI: 10.1517/13543776.18.9.1097  1
2007 Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. Acs Chemical Biology. 2: 408-18. PMID 17530731 DOI: 10.1021/cb700073y  1
2007 Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Organic Letters. 9: 2055-8. PMID 17480083 DOI: 10.1021/ol070376i  1
2007 Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. The Journal of Biological Chemistry. 282: 12388-96. PMID 17329245 DOI: 10.1074/jbc.M611549200  1
2006 Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 52: 831-43. PMID 17145504 DOI: 10.1016/j.neuron.2006.10.035  1
2006 Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12081-8. PMID 17108181 DOI: 10.1523/JNEUROSCI.3614-06.2006  1
2006 Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochemical and Biophysical Research Communications. 351: 57-63. PMID 17054906 DOI: 10.1016/j.bbrc.2006.09.162  1
2006 Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration. 1: 2. PMID 16930449 DOI: 10.1186/1750-1326-1-2  1
2006 Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quéléver G, Iwatsubo T, Kraus JL. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays. Journal of Medicinal Chemistry. 49: 4275-85. PMID 16821787 DOI: 10.1021/jm0602864  1
2006 Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 4184-9. PMID 16766183 DOI: 10.1016/j.bmcl.2006.05.091  1
2006 Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T. Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters. 16: 3813-6. PMID 16682195 DOI: 10.1016/j.bmcl.2006.04.025  1
2006 Keller PC, Tomita T, Hayashi I, Chandu D, Weber JD, Cistola DP, Kopan R. A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry. 45: 5351-8. PMID 16618124 DOI: 10.1021/bi052228a  1
2006 Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of Biological Chemistry. 281: 14670-6. PMID 16569643 DOI: 10.1074/jbc.M513012200  1
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158  1
2006 Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental Neuroscience. 28: 102-17. PMID 16508308 DOI: 10.1159/000090757  1
2006 Tomita T, Iwatsubo T. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current Pharmaceutical Design. 12: 661-70. PMID 16472155 DOI: 10.2174/138161206775474206  1
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025  1
2006 Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M. Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates Heterocycles. 70: 101-106.  1
2005 Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. The Journal of Biological Chemistry. 280: 41967-75. PMID 16234244 DOI: 10.1074/jbc.M509066200  1
2005 Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, ... ... Tomita T, et al. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2069-71. PMID 16204356 DOI: 10.1096/fj.05-3744fje  1
2005 Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma-secretase complex with lipid rafts. Journal of Lipid Research. 46: 904-12. PMID 15716592 DOI: 10.1194/jlr.M400333-JLR200  1
2005 Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. The Journal of Biological Chemistry. 280: 12967-75. PMID 15644323 DOI: 10.1074/jbc.M409829200  1
2004 Tomita T, Iwatsubo T. [Recent advances in Alzheimer's disease-related gamma-secretase complex]. Seikagaku. the Journal of Japanese Biochemical Society. 76: 666-70. PMID 15346905  1
2004 Tomita T, Iwatsubo T. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease. Drug News & Perspectives. 17: 321-5. PMID 15334182 DOI: 10.1358/dnp.2004.17.5.829036  1
2004 Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. The Journal of Biological Chemistry. 279: 38040-6. PMID 15215237 DOI: 10.1074/jbc.M405597200  1
2004 Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice. The European Journal of Neuroscience. 19: 2826-38. PMID 15147316 DOI: 10.1111/j.0953-816X.2004.03397.x  1
2004 Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity. Bioorganic & Medicinal Chemistry Letters. 14: 1983-5. PMID 15050642 DOI: 10.1016/j.bmcl.2004.01.067  1
2004 Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Molecular and Cellular Biology. 24: 2012-24. PMID 14966281 DOI: 10.1128/MCB.24.5.2012-2024.2004  1
2004 Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H. Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues Tetrahedron Letters. 45: 2323-2326. DOI: 10.1016/j.tetlet.2004.01.087  1
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/pnas.1735338100  1
2003 Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I. Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8513-25. PMID 13679420  1
2003 Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chemical Communications (Cambridge, England). 2244-5. PMID 13678222  1
2003 Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7  1
2003 Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 422: 438-41. PMID 12660785 DOI: 10.1038/nature01506  1
2003 Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. The Journal of Biological Chemistry. 278: 18664-70. PMID 12637581 DOI: 10.1074/jbc.M301619200  1
2003 Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298  1
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/nbdi.2002.0546  1
2002 Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. The Journal of Biological Chemistry. 277: 50198-205. PMID 12388554 DOI: 10.1074/jbc.M205352200  1
2002 Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/emboj/cdf541  1
2002 Tomita T, Katayama R, Takikawa R, Iwatsubo T. Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. Febs Letters. 520: 117-21. PMID 12044882 DOI: 10.1016/S0014-5793(02)02802-8  1
2002 Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. The Journal of Biological Chemistry. 277: 14965-75. PMID 11847232 DOI: 10.1074/jbc.M200897200  1
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  1
2001 Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/jbc.M008511200  1
2001 Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Biochemical and Biophysical Research Communications. 282: 96-102. PMID 11263977 DOI: 10.1006/bbrc.2001.4558  1
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... Tomita T, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/jbc.274.40.28669  1
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