Takeshi Iwatsubo, MD - Publications

Affiliations: 
Neuropathology and Neuroscience The University of Tokyo 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=45
Website:
http://www.sss.jst.go.jp/english/researcher/h19-02iwatsubo.html

305 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 14: 15. PMID 30975165 DOI: 10.1186/s13024-019-0315-7  0.6
2019 Gonçalves TJM, Boutillon F, Lefebvre S, Goffin V, Iwatsubo T, Wakabayashi T, Oury F, Armand AS. Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation. Scientific Reports. 9: 5878. PMID 30971718 DOI: 10.1038/s41598-019-42296-6  0.6
2019 Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A. Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 9: 2827. PMID 30808940 DOI: 10.1038/s41598-019-39494-7  0.6
2018 Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A. Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease. Acta Neuropathologica. PMID 29770843 DOI: 10.1007/s00401-018-1866-3  0.6
2018 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ and brain Aβ deposition . The Journal of Biological Chemistry. 293: 7267. PMID 29752420 DOI: 10.1074/jbc.AAC118.003576  0.6
2018 Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Human Molecular Genetics. PMID 29425337 DOI: 10.1093/hmg/ddy046  0.6
2018 Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184  1
2017 Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, ... ... Iwatsubo T, et al. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042514 DOI: 10.1073/pnas.1707151114  0.6
2016 Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T. Familial ALS-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila Melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. The Journal of Biological Chemistry. PMID 27634045 DOI: 10.1074/jbc.M116.729152  0.6
2016 Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T. Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo. Human Molecular Genetics. PMID 27466196 DOI: 10.1093/hmg/ddw239  1
2016 Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human Molecular Genetics. PMID 27179792 DOI: 10.1093/hmg/ddw146  1
2016 Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/srep23969  1
2016 Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1362-72. PMID 26818522 DOI: 10.1523/JNEUROSCI.5090-14.2016  0.4
2015 Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DM, Iwatsubo T, Hasegawa M. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathologica. PMID 26538150 DOI: 10.1007/s00401-015-1503-3  0.44
2015 Iwatsubo T, Kishi R, Miura T, Ohzono T, Yamaguchi T. Formation of Hydroxyapatite Skeletal Materials from Hydrogel Matrices via Artificial Biomineralization. The Journal of Physical Chemistry. B. 119: 8793-9. PMID 26101802 DOI: 10.1021/acs.jpcb.5b03181  1
2015 Doody RS, Raman R, Sperling RA, Seimers E, Sethuraman G, Mohs R, Farlow M, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS. Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer's disease. Alzheimer's Research & Therapy. 7: 36. PMID 26064192 DOI: 10.1186/s13195-015-0121-6  1
2015 Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T. Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease. Cell Reports. 11: 859-65. PMID 25937280 DOI: 10.1016/j.celrep.2015.04.017  1
2015 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of Biological Chemistry. 290: 15163-74. PMID 25918154 DOI: 10.1074/jbc.M114.622209  1
2015 Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Molecular Neurodegeneration. 10: 20. PMID 25888396 DOI: 10.1186/s13024-015-0014-y  1
2015 Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T. Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2646-56. PMID 25673856 DOI: 10.1523/JNEUROSCI.3164-14.2015  1
2015 Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T. Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity. Biochemical and Biophysical Research Communications. 457: 194-9. PMID 25545059 DOI: 10.1016/j.bbrc.2014.12.087  1
2015 Goto M, Abe O, Aoki S, Hayashi N, Miyati T, Takao H, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K. Influence of parameter settings in voxel-based morphometry 8. Using DARTEL and region-of-interest on reproducibility in gray matter volumetry. Methods of Information in Medicine. 54: 171-8. PMID 25345402 DOI: 10.3414/ME14-01-0049  1
2015 Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K. Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study. Radiological Physics and Technology. 8: 64-72. PMID 25261344 DOI: 10.1007/s12194-014-0295-9  1
2015 Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H. Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Human Molecular Genetics. 24: 540-58. PMID 25231903 DOI: 10.1093/hmg/ddu475  1
2015 Hendrix JA, Finger B, Weiner MW, Frisoni GB, Iwatsubo T, Rowe CC, Kim SY, Guinjoan SM, Sevlever G, Carrillo MC. The Worldwide Alzheimer's Disease Neuroimaging Initiative: An update Alzheimer's and Dementia. 11: 850-859. DOI: 10.1016/j.jalz.2015.05.008  1
2014 Villemagne VL, Kim SY, Rowe CC, Iwatsubo T. Imago Mundi, Imago AD, Imago ADNI. Alzheimer's Research & Therapy. 6: 62. PMID 25478022 DOI: 10.1186/s13195-014-0062-5  1
2014 Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, ... ... Iwatsubo T, et al. Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America. 111: 10544-9. PMID 25009180 DOI: 10.1073/pnas.1402171111  1
2014 Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T. New photocleavable linker: α-thioacetophenone-type linker. Bioorganic & Medicinal Chemistry Letters. 24: 2831-3. PMID 24841630 DOI: 10.1016/j.bmcl.2014.04.104  1
2014 Ito G, Fujimoto T, Kamikawaji S, Kuwahara T, Iwatsubo T. Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955. Plos One. 9: e97988. PMID 24836358 DOI: 10.1371/journal.pone.0097988  1
2014 Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T. Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nature Communications. 5: 3386. PMID 24577224 DOI: 10.1038/ncomms4386  1
2014 Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1370-9. PMID 24453327 DOI: 10.1523/JNEUROSCI.2440-13.2014  1
2014 Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. The New England Journal of Medicine. 370: 311-21. PMID 24450890 DOI: 10.1056/NEJMoa1312889  1
2014 Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Molecular Neurodegeneration. 9: 7. PMID 24410857 DOI: 10.1186/1750-1326-9-7  1
2014 Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M. Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation. Angewandte Chemie (International Ed. in English). 53: 1382-5. PMID 24339209 DOI: 10.1002/anie.201308001  1
2014 Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/j.str.2013.09.018  1
2014 Yamane T, Ikari Y, Nishio T, Ishii K, Ishii K, Kato T, Ito K, Silverman DH, Senda M, Asada T, Arai H, Sugishita M, Iwatsubo T. Visual-statistical interpretation of (18)F-FDG-PET images for characteristic Alzheimer patterns in a multicenter study: inter-rater concordance and relationship to automated quantitative evaluation. Ajnr. American Journal of Neuroradiology. 35: 244-9. PMID 23907243 DOI: 10.3174/ajnr.A3665  1
2013 Imabayashi E, Matsuda H, Tabira T, Arima K, Araki N, Ishii K, Yamashita F, Iwatsubo T. Comparison between brain CT and MRI for voxel-based morphometry of Alzheimer's disease. Brain and Behavior. 3: 487-93. PMID 24381817 DOI: 10.1002/brb3.146  1
2013 Iwatsubo T. [Current status and perspectives on the development of AD therapeutics based on amyloid cascade hypothesis]. Rinshō Shinkeigaku = Clinical Neurology. 53: 1039. PMID 24291872 DOI: DN/JST.JSTAGE/clinicalneurol/53.1039  1
2013 Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956  1
2013 Doody RS, Aisen PS, Iwatsubo T. Semagacestat for treatment of Alzheimer's disease. The New England Journal of Medicine. 369: 1661. PMID 24152267 DOI: 10.1056/NEJMc1310845  1
2013 Kamikawaji S, Ito G, Sano T, Iwatsubo T. Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation. Biochemistry. 52: 6052-62. PMID 23924436 DOI: 10.1021/bi400596m  1
2013 Doody RS, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas RG, Aisen PS, Siemers E, Sethuraman G, Mohs R, et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease. The New England Journal of Medicine. 369: 341-50. PMID 23883379 DOI: 10.1056/NEJMoa1210951  1
2013 Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T. Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. Bmc Biochemistry. 14: 16. PMID 23829174 DOI: 10.1186/1471-2091-14-16  1
2013 Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T. RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Human Molecular Genetics. 22: 4474-84. PMID 23804749 DOI: 10.1093/hmg/ddt296  1
2013 Maikusa N, Yamashita F, Tanaka K, Abe O, Kawaguchi A, Kabasawa H, Chiba S, Kasahara A, Kobayashi N, Yuasa T, Sato N, Matsuda H, Iwatsubo T. Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom. Medical Physics. 40: 062303. PMID 23718605 DOI: 10.1118/1.4801913  1
2013 Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. Plos One. 8: e64050. PMID 23667698 DOI: 10.1371/journal.pone.0064050  1
2013 Goto M, Abe O, Aoki S, Hayashi N, Miyati T, Takao H, Iwatsubo T, Yamashita F, Matsuda H, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K. Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects. Neuroradiology. 55: 869-75. PMID 23619702 DOI: 10.1007/s00234-013-1193-2  1
2013 Tomita T, Iwatsubo T. Structural biology of presenilins and signal peptide peptidases. The Journal of Biological Chemistry. 288: 14673-80. PMID 23585568 DOI: 10.1074/jbc.R113.463281  1
2013 Takusagawa S, Ushigome F, Nemoto H, Takahashi Y, Li Q, Kerbusch V, Miyashita A, Iwatsubo T, Usui T. Intestinal absorption mechanism of mirabegron, a potent and selective β₃-adrenoceptor agonist: involvement of human efflux and/or influx transport systems. Molecular Pharmaceutics. 10: 1783-94. PMID 23560393 DOI: 10.1021/mp300582s  0.4
2013 Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T. Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study. Annals of Nuclear Medicine. 27: 452-9. PMID 23483370 DOI: 10.1007/s12149-013-0704-x  1
2013 Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T. Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition. Journal of Medicinal Chemistry. 56: 1443-54. PMID 23342950 DOI: 10.1021/jm301306c  1
2013 Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T. Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry. 52: 61-9. PMID 23210549 DOI: 10.1021/bi301252r  1
2013 Hashimoto T, Suzuki K, Kihara Y, Iwatsubo T, Miyashita A, Heeringa M, Onkels H, Groenendaal D, Verheggen F, van Marle S, Usui T. Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 534-47. PMID 23167531 DOI: 10.3109/00498254.2012.738045  0.4
2013 Fujimoto Y, Iwatsubo T. Strengthening/Building Alzheimer's Disease Global Clinical Trial Site Capabilities and Capacity in and for Emerging Markets: Lessons Learned from Japan Global Clinical Trials For Alzheimer's Disease: Design, Implementation, and Standardization. 289-304. DOI: 10.1016/B978-0-12-411464-7.00018-3  1
2012 Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, ... ... Iwatsubo T, et al. Activity-dependent proteolytic cleavage of neuroligin-1. Neuron. 76: 410-22. PMID 23083742 DOI: 10.1016/j.neuron.2012.10.003  1
2012 Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier. Biopharmaceutics & Drug Disposition. 33: 304-15. PMID 22847220 DOI: 10.1002/bdd.1801  0.4
2012 Takusagawa S, Miyashita A, Iwatsubo T, Usui T. In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 42: 1187-96. PMID 22834478 DOI: 10.3109/00498254.2012.700140  0.4
2012 Goto M, Abe O, Miyati T, Kabasawa H, Takao H, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Mori H, Kunimatsu A, Aoki S, Ino K, Yano K, et al. Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method. Korean Journal of Radiology. 13: 391-402. PMID 22778560 DOI: 10.3348/kjr.2012.13.4.391  1
2012 Takeo K, Watanabe N, Tomita T, Iwatsubo T. Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein. The Journal of Biological Chemistry. 287: 25834-43. PMID 22689582 DOI: 10.1074/jbc.M111.336347  1
2012 Takusagawa S, Yajima K, Miyashita A, Uehara S, Iwatsubo T, Usui T. Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 42: 957-67. PMID 22509825 DOI: 10.3109/00498254.2012.675095  0.4
2012 Sato Y, Miyashita A, Iwatsubo T, Usui T. Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1389-96. PMID 22504157 DOI: 10.1124/dmd.112.045054  0.4
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Iwatsubo T, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/NEN.0b013e31825018f7  1
2012 Goto M, Abe O, Kabasawa H, Takao H, Miyati T, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Inano S, Mori H, Kunimatsu A, Aoki S, Ino K, et al. Effects of image distortion correction on voxel-based morphometry. Magnetic Resonance in Medical Sciences : Mrms : An Official Journal of Japan Society of Magnetic Resonance in Medicine. 11: 27-34. PMID 22450384 DOI: JST.JSTAGE/mrms/11.27  1
2012 Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3306-20. PMID 22399753 DOI: 10.1523/JNEUROSCI.5367-11.2012  1
2012 Shiraga T, Yajima K, Teragaki T, Suzuki K, Hashimoto T, Iwatsubo T, Miyashita A, Usui T. Identification of enzymes responsible for the N-oxidation of darexaban glucuronide, the pharmacologically active metabolite of darexaban, and the glucuronidation of darexaban N-oxides in human liver microsomes. Biological & Pharmaceutical Bulletin. 35: 413-21. PMID 22382330 DOI: JST.JSTAGE/bpb/35.413  0.4
2012 De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine. 2: a006304. PMID 22315713 DOI: 10.1101/cshperspect.a006304  1
2012 Sato Y, Miyashita A, Iwatsubo T, Usui T. Conclusive identification of the oxybutynin-hydrolyzing enzyme in human liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 902-6. PMID 22293119 DOI: 10.1124/dmd.111.043208  0.4
2012 Takusagawa S, van Lier JJ, Suzuki K, Nagata M, Meijer J, Krauwinkel W, Schaddelee M, Sekiguchi M, Miyashita A, Iwatsubo T, van Gelderen M, Usui T. Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 815-24. PMID 22269146 DOI: 10.1124/dmd.111.043588  0.4
2012 Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T. Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans. The Journal of Biological Chemistry. 287: 7098-109. PMID 22232559 DOI: 10.1074/jbc.M111.237131  1
2012 Ito G, Iwatsubo T. Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form. The Biochemical Journal. 441: 987-94. PMID 22047502 DOI: 10.1042/BJ20111215  1
2012 Shiraga T, Yajima K, Suzuki K, Suzuki K, Hashimoto T, Iwatsubo T, Miyashita A, Usui T. Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 276-82. PMID 22031623 DOI: 10.1124/dmd.111.042614  0.4
2012 Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, ... Iwatsubo T, et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 31: 787-98. PMID 21725355 DOI: 10.1038/onc.2011.265  1
2011 Iwatsubo T. [Alzheimer's disease Neuroimaging Initiative (ADNI)]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 69: 570-4. PMID 22787853  1
2011 Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H. Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. Plos One. 6: e27408. PMID 22096569 DOI: 10.1371/journal.pone.0027408  1
2011 Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. The Journal of Biological Chemistry. 286: 44569-75. PMID 22074918 DOI: 10.1074/jbc.M111.270108  1
2011 Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The Embo Journal. 30: 4815-24. PMID 22002539 DOI: 10.1038/emboj.2011.372  1
2011 Iwai M, Minematsu T, Li Q, Iwatsubo T, Usui T. Utility of P-glycoprotein and organic cation transporter 1 double-transfected LLC-PK1 cells for studying the interaction of YM155 monobromide, novel small-molecule survivin suppressant, with P-glycoprotein. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2314-20. PMID 21918035 DOI: 10.1124/dmd.111.040733  0.4
2011 Iwatsubo T. [Dementia: progress in diagnosis and treatment; editorial, towards the preclinical treatment of Alzheimer disease]. Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine. 100: 2089-91. PMID 21899138  1
2011 Iwatsubo T. [Molecular pathology and disease-modifying therapy of Alzheimer disease]. Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica. 113: 568-73. PMID 21815468  1
2011 Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T. Three-dimensional structure of the signal peptide peptidase. The Journal of Biological Chemistry. 286: 26188-97. PMID 21636854 DOI: 10.1074/jbc.M111.260273  1
2011 Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T. Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. Journal of Neurochemistry. 118: 407-15. PMID 21585370 DOI: 10.1111/j.1471-4159.2011.07311.x  1
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1523/JNEUROSCI.6467-10.2011  1
2011 Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 280-92. PMID 21514248 DOI: 10.1016/j.jalz.2011.03.003  1
2010 Iwatsubo T. J-ADNI. Rinshō Shinkeigaku = Clinical Neurology. 50: 935. PMID 21921517 DOI: JST.JSTAGE/clinicalneurol/50.935  1
2010 Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15943-50. PMID 21106832 DOI: 10.1523/JNEUROSCI.3318-10.2010  1
2010 Morohashi Y, Tomita T, Iwatsubo T. [Molecular targeted therapy in Alzheimer disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 68: 1906-10. PMID 20954338  1
2010 Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503  1
2010 Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M. Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. The Journal of Biological Chemistry. 285: 34885-98. PMID 20805224 DOI: 10.1074/jbc.M110.148460  1
2010 Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66. PMID 20720123 DOI: 10.1523/JNEUROSCI.2884-10.2010  1
2010 Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H. Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. Bioorganic & Medicinal Chemistry Letters. 20: 5282-5. PMID 20650635 DOI: 10.1016/j.bmcl.2010.06.131  1
2010 Kamimura H, Nakada N, Suzuki K, Mera A, Souda K, Murakami Y, Tanaka K, Iwatsubo T, Kawamura A, Usui T. Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites. Drug Metabolism and Pharmacokinetics. 25: 223-35. PMID 20610881 DOI: JST.JSTAGE/dmpk/25.223  0.4
2010 Iwatsubo T. Japanese Alzheimer's Disease Neuroimaging Initiative: present status and future. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 297-9. PMID 20451880 DOI: 10.1016/j.jalz.2010.03.011  1
2010 Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. The Journal of Biological Chemistry. 285: 19738-46. PMID 20418378 DOI: 10.1074/jbc.M110.101287  1
2010 Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK. Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Science Signaling. 3: ra22. PMID 20332427 DOI: 10.1126/scisignal.2000818  1
2010 Jahan RA, Suzuki K, Mahara H, Nishimura S, Iwatsubo T, Kaminaga A, Yamamoto Y, Yamaguchi T. Perturbation mechanism and phase transition of AOT aggregates in the Fe(II)[batho(SO3)2]3 - catalyzed aqueous Belousov-Zhabotinsky reaction Chemical Physics Letters. 485: 304-308. DOI: 10.1016/j.cplett.2009.12.050  1
2010 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Corrigendum to "Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" [Bioorg. Med. Chem. Lett. 19 (2009) 6869] (DOI:10.1016/j.bmcl.2009.10.086) Bioorganic and Medicinal Chemistry Letters. 20: 1798-1799. DOI: 10.1016/j.bmcl.2010.01.025  1
2009 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorganic & Medicinal Chemistry Letters. 19: 6869-71. PMID 19892551 DOI: 10.1016/j.bmcl.2009.10.086  1
2009 Kamikawaji S, Ito G, Iwatsubo T. Identification of the autophosphorylation sites of LRRK2. Biochemistry. 48: 10963-75. PMID 19824698 DOI: 10.1021/bi9011379  1
2009 Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Science. 100: 2444-50. PMID 19775286 DOI: 10.1111/j.1349-7006.2009.01328.x  1
2009 Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T. Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11393-8. PMID 19741145 DOI: 10.1523/JNEUROSCI.2021-09.2009  1
2009 Umehara K, Nakada N, Noguchi K, Iwatsubo T, Usui T, Kamimura H. Investigation of long-term retention of unchanged (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide, a novel "funny" If current channel inhibitor, and its metabolites in the eyeball and thoracic aorta of rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 2137-44. PMID 19704029 DOI: 10.1124/dmd.109.027813  0.4
2009 Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/jbc.M109.055061  1
2009 Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, et al. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9210-8. PMID 19625511 DOI: 10.1523/JNEUROSCI.2281-09.2009  1
2009 Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H. Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biological & Pharmaceutical Bulletin. 32: 999-1003. PMID 19483305 DOI: JST.JSTAGE/bpb/32.999  1
2009 Umehara K, Shirai N, Iwatsubo T, Noguchi K, Usui T, Kamimura H. Identification of human metabolites of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel If channel inhibitor, and investigation of the transporter-mediated renal and hepatic excretion of these metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1646-57. PMID 19439489 DOI: 10.1124/dmd.108.026294  0.4
2009 Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. Journal of the American Chemical Society. 131: 7353-9. PMID 19432477 DOI: 10.1021/ja9001458  1
2009 Umehara K, Wada K, Noguchi K, Iwatsubo T, Usui T, Kamimura H. Relationship between exposure of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a "funny" if current channel inhibitor, and heart rate reduction in tachycardia-induced beagle dogs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1427-33. PMID 19359407 DOI: 10.1124/dmd.108.026385  0.4
2009 Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, ... Iwatsubo T, et al. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Molecular Psychiatry. 14: 1004-16. PMID 19204726 DOI: 10.1038/mp.2009.10  1
2009 Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P. Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease. Human Molecular Genetics. 18: 872-87. PMID 19074459 DOI: 10.1093/hmg/ddn417  1
2009 Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/jbc.M806380200  1
2009 Suzuki K, Akthar RJ, Mahara H, Hashimoto H, Iwatsubo T, Nishimura S, Yamaguchi T. Self-organization of multilayered oil droplet in water Chemistry Letters. 38: 20-21. DOI: 10.1246/cl.2009.20  1
2009 Iwatsubo T. Disease-modifying therapy of Alzheimer's disease and Japanese ADNI Japanese Journal of Geriatrics. 46: 373-379.  1
2008 Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, et al. Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Molecular Brain. 1: 17. PMID 19021916 DOI: 10.1186/1756-6606-1-17  1
2008 Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry. 283: 34554-62. PMID 18940800 DOI: 10.1074/jbc.M801487200  1
2008 Umehara KI, Seya K, Iwatsubo T, Noguchi K, Usui T, Kamimura H. Tissue distribution of YM758, a novel If channel inhibitor, in pregnant and lactating rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 38: 1274-88. PMID 18800311 DOI: 10.1080/00498250802426106  0.4
2008 Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S. Lewy body pathology involves cutaneous nerves. Journal of Neuropathology and Experimental Neurology. 67: 945-53. PMID 18800013 DOI: 10.1097/NEN.0b013e318186de48  1
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/JCI35781  1
2008 Umehara KI, Iwatsubo T, Noguchi K, Usui T, Kamimura H. Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 38: 1203-18. PMID 18686197 DOI: 10.1080/00498250802334409  0.4
2008 Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathologica. 116: 277-88. PMID 18626651 DOI: 10.1007/s00401-008-0409-8  1
2008 Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren CH, Kato T, Mitani S, Iwatsubo T. A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Human Molecular Genetics. 17: 2997-3009. PMID 18617532 DOI: 10.1093/hmg/ddn198  1
2008 Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL. Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 23: 996-1001. PMID 18608784 DOI: 10.1080/14756360701832706  1
2008 Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/j.neuron.2008.04.015  1
2008 Sato C, Takagi S, Tomita T, Iwatsubo T. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6264-71. PMID 18550769 DOI: 10.1523/JNEUROSCI.1163-08.2008  1
2008 Fujita E, Teramura Y, Mitsugi K, Ninomiya S, Iwatsubo T, Kawamura A, Kamimura H. Absorption, distribution, and excretion of 14C-labeled tacrolimus (FK506) after a single or repeated ocular instillation in rabbits. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 24: 333-43. PMID 18476802 DOI: 10.1089/jop.2007.0086  0.4
2008 Fujita E, Teramura Y, Shiraga T, Yoshioka S, Iwatsubo T, Kawamura A, Kamimura H. Pharmacokinetics and tissue distribution of tacrolimus (FK506) after a single or repeated ocular instillation in rabbits. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 24: 309-19. PMID 18476801 DOI: 10.1089/jop.2007.0083  0.4
2008 Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan CF, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A. Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia. Archives of Neurology. 65: 514-9. PMID 18413475 DOI: 10.1001/archneur.65.4.514  1
2008 Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell & Melanoma Research. 21: 70-8. PMID 18353145 DOI: 10.1111/j.1755-148X.2007.00423.x  1
2008 Umehara K, Iwai M, Adachi Y, Iwatsubo T, Usui T, Kamimura H. Hepatic uptake and excretion of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel if channel inhibitor, in rats and humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1030-8. PMID 18332079 DOI: 10.1124/dmd.108.020669  0.4
2008 Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neuro-Degenerative Diseases. 5: 222-4. PMID 18322396 DOI: 10.1159/000113708  1
2008 Umehara KI, Iwatsubo T, Noguchi K, Kamimura H. Functional involvement of the organic cation transporter 2 (rOct2) in the renal uptake of organic cations in rats. The Journal of International Medical Research. 36: 123-36. PMID 18230276  0.4
2008 Akanuma S, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T. ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier. Neurochemistry International. 52: 956-61. PMID 18201804 DOI: 10.1016/j.neuint.2007.12.002  1
2008 Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K. Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro. Journal of Biochemistry. 143: 475-86. PMID 18174189 DOI: 10.1093/jb/mvm239  1
2008 Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H. Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Experimental Neurology. 210: 409-20. PMID 18164295 DOI: 10.1016/j.expneurol.2007.11.019  1
2008 Takatori S, Ito G, Iwatsubo T. Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. Neuroscience Letters. 430: 13-7. PMID 18031932 DOI: 10.1016/j.neulet.2007.10.019  1
2008 Ichibangase T, Saimaru H, Takamura N, Kuwahara T, Koyama A, Iwatsubo T, Imai K. Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages. Biomedical Chromatography : Bmc. 22: 232-4. PMID 17939164 DOI: 10.1002/bmc.931  1
2008 Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S, Kobayashi K, Iwatsubo T, Yoshimoto M. Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice. Neurobiology of Aging. 29: 574-85. PMID 17174013 DOI: 10.1016/j.neurobiolaging.2006.11.017  1
2008 Iwatsubo T, Yamaguchi T. Hypercomplex gel changes to organic/inorganic solid solution by phase transition in an artificial biomineralization system Polymer Journal. 40: 958-964. DOI: 10.1295/polymj.PJ2008121  1
2007 Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13092-7. PMID 18045903 DOI: 10.1523/JNEUROSCI.4244-07.2007  1
2007 Iwatsubo T. Pathological biochemistry of alpha-synucleinopathy. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 27: 474-8. PMID 18018483 DOI: 10.1111/j.1440-1789.2007.00785.x  1
2007 Yanagihara T, Aoki T, Soeishi Y, Iwatsubo T, Kamimura H. Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 859: 241-5. PMID 17977808 DOI: 10.1016/j.jchromb.2007.10.005  0.4
2007 Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi T, Hisanaga S, Iwatsubo T, Hasegawa M, Kato K. Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein. Biochemical and Biophysical Research Communications. 363: 795-9. PMID 17904099 DOI: 10.1016/j.bbrc.2007.09.048  1
2007 Ishii A, Nonaka T, Taniguchi S, Saito T, Arai T, Mann D, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M. Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies. Febs Letters. 581: 4711-7. PMID 17868672 DOI: 10.1016/j.febslet.2007.08.067  1
2007 Umehara KI, Iwatsubo T, Noguchi K, Kamimura H. Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 37: 818-31. PMID 17701831 DOI: 10.1080/00498250701546012  0.4
2007 Umehara KI, Iwatsubo T, Noguchi K, Kamimura H. Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 37: 618-34. PMID 17614008 DOI: 10.1080/00498250701397705  0.4
2007 Haleem K, Lippa CF, Smith TW, Kowa H, Wu J, Iwatsubo T. Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. American Journal of Alzheimer's Disease and Other Dementias. 22: 137-44. PMID 17545141 DOI: 10.1177/1533317506298051  1
2007 Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T. Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation. Analytical Chemistry. 79: 4887-91. PMID 17536782 DOI: 10.1021/ac0701482  1
2007 Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. Acs Chemical Biology. 2: 408-18. PMID 17530731 DOI: 10.1021/cb700073y  1
2007 Fumimura Y, Ikemura M, Saito Y, Sengoku R, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Mizusawa H, Murayama S. Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease. Journal of Neuropathology and Experimental Neurology. 66: 354-62. PMID 17483692 DOI: 10.1097/nen.0b013e3180517454  1
2007 Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Organic Letters. 9: 2055-8. PMID 17480083 DOI: 10.1021/ol070376i  1
2007 Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M. Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein. Journal of Neuroscience Research. 85: 1819-25. PMID 17465029 DOI: 10.1002/jnr.21310  1
2007 Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, ... ... Iwatsubo T, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 68: 812-9. PMID 17353469 DOI: 10.1212/01.wnl.0000256715.13907.d3  1
2007 Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. The Journal of Biological Chemistry. 282: 12388-96. PMID 17329245 DOI: 10.1074/jbc.M611549200  1
2007 Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kosaka K, Kato M, Iwatsubo T, Arai H. Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies. Neuroscience Letters. 415: 219-24. PMID 17275187 DOI: 10.1016/j.neulet.2007.01.029  1
2007 Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T. GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry. 46: 1380-8. PMID 17260967 DOI: 10.1021/bi061960m  1
2007 Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. The Journal of Biological Chemistry. 282: 4916-23. PMID 17170111 DOI: 10.1074/jbc.M608220200  1
2007 Wakabayashi T, Iwatsubo T, De Strooper B. The biology of the presenilin complexes Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 35-58. DOI: 10.1007/978-0-387-35135-3_3  1
2007 Iwatsubo T. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 401-402.  1
2006 Iwatsubo T. [Beta- and gamma-secretases]. Rinshō Shinkeigaku = Clinical Neurology. 46: 925-6. PMID 17432221  1
2006 Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 52: 831-43. PMID 17145504 DOI: 10.1016/j.neuron.2006.10.035  1
2006 Zhu X, Babar A, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG. LRRK2 in Parkinson's disease and dementia with Lewy bodies. Molecular Neurodegeneration. 1: 17. PMID 17137507 DOI: 10.1186/1750-1326-1-17  1
2006 Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12081-8. PMID 17108181 DOI: 10.1523/JNEUROSCI.3614-06.2006  1
2006 Iwatsubo T. Tauopathy: an overview. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 26: 455-6. PMID 17080725 DOI: 10.1111/j.1440-1789.2006.00667.x  1
2006 Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochemical and Biophysical Research Communications. 351: 57-63. PMID 17054906 DOI: 10.1016/j.bbrc.2006.09.162  1
2006 Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min do S, Kim J, Paik SR, Chung KC. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. The Journal of Biological Chemistry. 281: 33250-7. PMID 16959772 DOI: 10.1074/jbc.M606147200  1
2006 Arawaka S, Wada M, Goto S, Karube H, Sakamoto M, Ren CH, Koyama S, Nagasawa H, Kimura H, Kawanami T, Kurita K, Tajima K, Daimon M, Baba M, Kido T, ... ... Iwatsubo T, et al. The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9227-38. PMID 16957079 DOI: 10.1523/JNEUROSCI.0341-06.2006  1
2006 Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration. 1: 2. PMID 16930449 DOI: 10.1186/1750-1326-1-2  1
2006 Sato C, Iwatsubo T. Focusing on beta-amyloid: report of the 35th Annual Meeting of the Society for Neuroscience. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 114-6. PMID 16911967 DOI: 10.1080/13506120600722738  1
2006 Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zolo P, Arima K, Iseki E, ... ... Iwatsubo T, et al. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathology and Applied Neurobiology. 32: 374-87. PMID 16866983 DOI: 10.1111/j.1365-2990.2006.00736.x  1
2006 Iwatsubo T, Ihara Y, Kanazawa I. Alzheimer disease research in Japan: public funding. Nature Medicine. 12: 778-9. PMID 16829946 DOI: 10.1038/nm0706-778  1
2006 Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quéléver G, Iwatsubo T, Kraus JL. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays. Journal of Medicinal Chemistry. 49: 4275-85. PMID 16821787 DOI: 10.1021/jm0602864  1
2006 Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharmaceutical Research. 23: 1407-16. PMID 16779710 DOI: 10.1007/s11095-006-0208-7  1
2006 Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 4184-9. PMID 16766183 DOI: 10.1016/j.bmcl.2006.05.091  1
2006 Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T. Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters. 16: 3813-6. PMID 16682195 DOI: 10.1016/j.bmcl.2006.04.025  1
2006 Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M. Small molecule inhibitors of alpha-synuclein filament assembly. Biochemistry. 45: 6085-94. PMID 16681381 DOI: 10.1021/bi0600749  1
2006 Tian J, Shi J, Smallman R, Iwatsubo T, Mann DM. Relationships in Alzheimer's disease between the extent of Abeta deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen. Neuropathology and Applied Neurobiology. 32: 332-40. PMID 16640651 DOI: 10.1111/j.1365-2990.2006.00732.x  1
2006 Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kato M, Iwatsubo T, Kosaka K, Arai H. Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies. Journal of the Neurological Sciences. 246: 95-101. PMID 16624323 DOI: 10.1016/j.jns.2006.02.016  1
2006 Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of Biological Chemistry. 281: 14670-6. PMID 16569643 DOI: 10.1074/jbc.M513012200  1
2006 de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, ... ... Iwatsubo T, et al. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathologica. 111: 329-40. PMID 16552612 DOI: 10.1007/s00401-006-0048-x  1
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158  0.64
2006 Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, et al. Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype. Journal of Neurology, Neurosurgery, and Psychiatry. 77: 515-7. PMID 16543533 DOI: 10.1136/jnnp.2005.063917  1
2006 Bensemain F, Chapuis J, Tian J, Shi J, Thaker U, Lendon C, Iwatsubo T, Amouyel P, Mann D, Lambert JC. Association study of the Ubiquilin gene with Alzheimer's disease. Neurobiology of Disease. 22: 691-3. PMID 16504527 DOI: 10.1016/j.nbd.2006.01.007  1
2006 Tomita T, Iwatsubo T. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current Pharmaceutical Design. 12: 661-70. PMID 16472155 DOI: 10.2174/138161206775474206  1
2006 Iwatsubo T, Sumaru K, Kanamori T, Shinbo T, Yamaguchi T. Construction of a new artificial biomineralization system. Biomacromolecules. 7: 95-100. PMID 16398503 DOI: 10.1021/bm0504476  1
2006 Shi J, Tian J, Pritchard A, Lendon C, Lambert JC, Iwatsubo T, Mann DM. A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathologica. 111: 15-20. PMID 16328515 DOI: 10.1007/s00401-005-1108-3  1
2006 Ito G, Ariga H, Nakagawa Y, Iwatsubo T. Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. Biochemical and Biophysical Research Communications. 339: 667-72. PMID 16316629 DOI: 10.1016/j.bbrc.2005.11.058  1
2006 Kuwahara T, Koyama A, Gengyo-Ando K, Masuda M, Kowa H, Tsunoda M, Mitani S, Iwatsubo T. Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. The Journal of Biological Chemistry. 281: 334-40. PMID 16260788 DOI: 10.1074/jbc.M504860200  1
2006 Kusumocahyo SP, Sumaru K, Iwatsubo T, Shinbo T, Kanamori T, Matsuyama H, Teramoto M. Quantitative analysis of transport process of cerium(III) ion through polymer inclusion membrane containing N,N,N′,N′-tetraoctyl-3-oxapentanediamide (TODGA) as carrier Journal of Membrane Science. 280: 73-81. DOI: 10.1016/j.memsci.2006.01.007  1
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025  1
2006 Kusumocahyo SP, Kanamori T, Iwatsubo T, Sumaru K, Shinbo T, Matsuyama H, Teramoto M. Modification of preparation method for polymer inclusion membrane (PIM) to produce hollow fiber PIM Journal of Applied Polymer Science. 102: 4372-4377. DOI: 10.1002/app.24991  1
2006 Iwatsubo T, Kusumocahyo SP, Kanamori T, Shinbo T. Mineralization of hydroxyapatite on a polymer substrate in a solution supersaturated by polyelectrolyte Journal of Applied Polymer Science. 100: 1465-1470. DOI: 10.1002/app.23496  1
2006 Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M. Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates Heterocycles. 70: 101-106.  1
2005 Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E. Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10689-99. PMID 16291942 DOI: 10.1523/JNEUROSCI.3527-05.2005  1
2005 McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, ... ... Iwatsubo T, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 65: 1863-72. PMID 16237129 DOI: 10.1212/01.wnl.0000187889.17253.b1  1
2005 Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. The Journal of Biological Chemistry. 280: 41967-75. PMID 16234244 DOI: 10.1074/jbc.M509066200  1
2005 Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, ... ... Iwatsubo T, et al. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2069-71. PMID 16204356 DOI: 10.1096/fj.05-3744fje  1
2005 Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA. Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5544-52. PMID 15944382 DOI: 10.1523/JNEUROSCI.0482-05.2005  1
2005 Pritchard A, Harris J, Pritchard CW, St Clair D, Lemmon H, Lambert JC, Chartier-Harlin MC, Hayes A, Thaker U, Iwatsubo T, Mann DM, Lendon C. Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease. Neuroscience Letters. 382: 221-6. PMID 15925094 DOI: 10.1016/j.neulet.2005.03.016  0.32
2005 Machida Y, Chiba T, Takayanagi A, Tanaka Y, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Tanaka K, Mizuno Y, Hattori N. Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells. Biochemical and Biophysical Research Communications. 332: 233-40. PMID 15896322 DOI: 10.1016/j.bbrc.2005.04.124  0.36
2005 Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma-secretase complex with lipid rafts. Journal of Lipid Research. 46: 904-12. PMID 15716592 DOI: 10.1194/jlr.M400333-JLR200  1
2005 Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. The Journal of Biological Chemistry. 280: 12967-75. PMID 15644323 DOI: 10.1074/jbc.M409829200  1
2005 Nonaka T, Iwatsubo T, Hasegawa M. Ubiquitination of alpha-synuclein. Biochemistry. 44: 361-8. PMID 15628878 DOI: 10.1021/bi0485528  0.44
2005 Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T. CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. The Journal of Biological Chemistry. 280: 8596-605. PMID 15615705 DOI: 10.1074/jbc.M413340200  0.6
2005 Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. The Journal of Biological Chemistry. 280: 7614-23. PMID 15611092 DOI: 10.1074/jbc.M408714200  1
2004 Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 17510-5. PMID 15576511 DOI: 10.1073/pnas.0405313101  1
2004 Nonaka T, Iwatsubo T, Hasegawa M. [Analysis of alpha-synuclein and its significance]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 62: 1623-8. PMID 15462375  0.44
2004 Tomita T, Iwatsubo T. [Recent advances in Alzheimer's disease-related gamma-secretase complex]. Seikagaku. the Journal of Japanese Biochemical Society. 76: 666-70. PMID 15346905  1
2004 Tomita T, Iwatsubo T. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease. Drug News & Perspectives. 17: 321-5. PMID 15334182 DOI: 10.1358/dnp.2004.17.5.829036  1
2004 Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M. Phosphorylated alpha-synuclein in normal mouse brain. Febs Letters. 572: 227-32. PMID 15304353 DOI: 10.1016/j.febslet.2004.07.046  0.44
2004 Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. The Journal of Biological Chemistry. 279: 38040-6. PMID 15215237 DOI: 10.1074/jbc.M405597200  1
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American Journal of Pathology. 165: 273-81. PMID 15215182  1
2004 Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K. Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 75: 1039-42. PMID 15201367 DOI: 10.1136/jnnp.2003.010611  1
2004 Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H. Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. The Journal of Cell Biology. 165: 893-902. PMID 15197174 DOI: 10.1083/jcb.200310024  1
2004 Zhang Y, Hayes A, Pritchard A, Thaker U, Haque MS, Lemmon H, Harris J, Cumming A, Lambert JC, Chartier-Harlin MC, St Clair D, Iwatsubo T, Mann DM, Lendon CL. Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease. Neuroscience Letters. 362: 99-102. PMID 15193763 DOI: 10.1016/j.neulet.2004.03.008  0.32
2004 Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice. The European Journal of Neuroscience. 19: 2826-38. PMID 15147316 DOI: 10.1111/j.0953-816X.2004.03397.x  1
2004 Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, ... ... Iwatsubo T, et al. Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. Neuromolecular Medicine. 5: 133-46. PMID 15075440 DOI: 10.1385/NMM:5:2:133  1
2004 Umeda Y, Taniguchi S, Arima K, Piao YS, Takahashi H, Iwatsubo T, Mann D, Hasegawa M. Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neuroscience Letters. 359: 151-4. PMID 15050686 DOI: 10.1016/j.neulet.2004.01.060  0.44
2004 Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity. Bioorganic & Medicinal Chemistry Letters. 14: 1983-5. PMID 15050642 DOI: 10.1016/j.bmcl.2004.01.067  1
2004 Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Molecular and Cellular Biology. 24: 2012-24. PMID 14966281 DOI: 10.1128/MCB.24.5.2012-2024.2004  1
2004 Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K. Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathologica. 107: 292-8. PMID 14722716 DOI: 10.1007/s00401-003-0811-1  0.44
2004 Taniguchi S, McDonagh AM, Pickering-Brown SM, Umeda Y, Iwatsubo T, Hasegawa M, Mann DM. The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathology and Applied Neurobiology. 30: 1-18. PMID 14720172  0.44
2004 Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM. Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective. The Journal of Biological Chemistry. 279: 4625-31. PMID 14627698 DOI: 10.1074/jbc.M310994200  1
2003 Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J. Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. Journal of Neuropathology and Experimental Neurology. 62: 1108-17. PMID 14656069  0.6
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/pnas.1735338100  1
2003 Mori F, Piao YS, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K. Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy. Journal of Neuropathology and Experimental Neurology. 62: 812-9. PMID 14503637  0.44
2003 Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I. Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8513-25. PMID 13679420  1
2003 Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chemical Communications (Cambridge, England). 2244-5. PMID 13678222  1
2003 Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S. Accumulation of phosphorylated alpha-synuclein in aging human brain. Journal of Neuropathology and Experimental Neurology. 62: 644-54. PMID 12834109  0.44
2003 Lambert JC, Luedecking-Zimmer E, Merrot S, Hayes A, Thaker U, Desai P, Houzet A, Hermant X, Cottel D, Pritchard A, Iwatsubo T, Pasquier F, Frigard B, Conneally PM, Chartier-Harlin MC, et al. Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. Journal of Medical Genetics. 40: 424-30. PMID 12807963  1
2003 Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7  1
2003 Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 422: 438-41. PMID 12660785 DOI: 10.1038/nature01506  1
2003 Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. The Journal of Biological Chemistry. 278: 18664-70. PMID 12637581 DOI: 10.1074/jbc.M301619200  1
2003 Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298  1
2003 Thaker U, McDonagh AM, Iwatsubo T, Lendon CL, Pickering-Brown SM, Mann DM. Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, Abeta40, in sporadic and familial Alzheimer's disease. Neuropathology and Applied Neurobiology. 29: 35-44. PMID 12581338  0.32
2003 Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T. Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila. Neuroscience Letters. 336: 155-8. PMID 12505616  0.44
2002 Ito K, Chiba K, Horikawa M, Ishigami M, Mizuno N, Aoki J, Gotoh Y, Iwatsubo T, Kanamitsu S, Kato M, Kawahara I, Niinuma K, Nishino A, Sato N, Tsukamoto Y, et al. Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data? Aaps Pharmsci. 4: E25. PMID 12645997 DOI: 10.1208/ps040425  0.4
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/nbdi.2002.0546  1
2002 Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/JCI15777  1
2002 Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. The Journal of Biological Chemistry. 277: 50198-205. PMID 12388554 DOI: 10.1074/jbc.M205352200  1
2002 Hayes A, Thaker U, Iwatsubo T, Pickering-Brown SM, Mann DM. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience Letters. 331: 171-4. PMID 12383924  0.32
2002 Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM, Trojanowski JQ, Mann D, Iwatsubo T. Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions. The Journal of Biological Chemistry. 277: 49071-6. PMID 12377775 DOI: 10.1074/jbc.M208046200  0.44
2002 Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/emboj/cdf541  1
2002 Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T. A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neuroscience Letters. 330: 84-8. PMID 12213640  0.44
2002 Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin MC, Iwatsubo T, Pickering-Brown SM, Mann DM. The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease. Neuroscience Letters. 328: 314-8. PMID 12147333  0.32
2002 Araria-Goumidi L, Lambert JC, Mann DM, Lendon C, Frigard B, Iwatsubo T, Cottel D, Amouyel P, Chartier-Harlin MC. Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 73: 62-4. PMID 12082048  0.32
2002 Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I. Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochemical and Biophysical Research Communications. 294: 429-40. PMID 12051730 DOI: 10.1016/S0006-291X(02)00498-9  0.36
2002 Tomita T, Katayama R, Takikawa R, Iwatsubo T. Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. Febs Letters. 520: 117-21. PMID 12044882 DOI: 10.1016/S0014-5793(02)02802-8  1
2002 Green EK, Harris JM, Lemmon H, Lambert JC, Chartier-Harlin MC, St Clair D, Mann DM, Iwatsubo T, Lendon CL. Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD? Neurology. 58: 1566-8. PMID 12034804  0.32
2002 Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C. Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. Embo Reports. 3: 583-8. PMID 12034752 DOI: 10.1093/embo-reports/kvf109  1
2002 Green EK, Thaker U, McDonagh AM, Iwatsubo T, Lambert JC, Chartier-Harlin MC, Harris JM, Pickering-Brown SM, Lendon CL, Mann DM. A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain. Neuroscience Letters. 324: 113-6. PMID 11988340  0.32
2002 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. The Embo Journal. 21: 1524-34. PMID 11927537 DOI: 10.1093/emboj/21.7.1524  0.6
2002 Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H. Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Annals of Neurology. 51: 525-30. PMID 11921059 DOI: 10.1002/ana.10163  0.44
2002 Miake H, Mizusawa H, Iwatsubo T, Hasegawa M. Biochemical characterization of the core structure of alpha-synuclein filaments. The Journal of Biological Chemistry. 277: 19213-9. PMID 11893734 DOI: 10.1074/jbc.M110551200  0.44
2002 Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. The Journal of Biological Chemistry. 277: 14965-75. PMID 11847232 DOI: 10.1074/jbc.M200897200  1
2002 Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biology. 4: 160-4. PMID 11813001 DOI: 10.1038/ncb748  0.44
2001 Hirota N, Ito K, Iwatsubo T, Green CE, Tyson CA, Shimada N, Suzuki H, Sugiyama Y. In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans. Biopharmaceutics & Drug Disposition. 22: 53-71. PMID 11745908 DOI: 10.1002/bdd.261  0.4
2001 Ikegaya Y, Kim JA, Baba M, Iwatsubo T, Nishiyama N, Matsuki N. Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity. Journal of Cell Science. 114: 4083-93. PMID 11739640  1
2001 Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y. Tau accumulation in a patient with pallidonigroluysian atrophy. Neuroscience Letters. 309: 89-92. PMID 11502352  0.44
2001 Mann DM, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M, Kalimo H, Iwatsubo T. Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques. Neuropathology and Applied Neurobiology. 27: 189-96. PMID 11489138 DOI: 10.1046/j.1365-2990.2001.00316.x  1
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  1
2001 Mann DM, Pickering-Brown SM, Takeuchi A, Iwatsubo T. Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease. The American Journal of Pathology. 158: 2165-75. PMID 11395394  1
2001 Lambert JC, Mann DM, Harris JM, Chartier-Harlin MC, Cumming A, Coates J, Lemmon H, StClair D, Iwatsubo T, Lendon C. The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain. Journal of Medical Genetics. 38: 353-5. PMID 11389157  0.32
2001 Verkkoniemi A, Kalimo H, Paetau A, Somer M, Iwatsubo T, Hardy J, Haltia M. Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype. Journal of Neuropathology and Experimental Neurology. 60: 483-92. PMID 11379823  1
2001 Mann DM, McDonagh AM, Pickering-Brown SM, Kowa H, Iwatsubo T. Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype. Neuroscience Letters. 304: 161-4. PMID 11343827  0.32
2001 Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T. Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis. Annals of Neurology. 49: 501-11. PMID 11310628  0.44
2001 Piao YS, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi H. Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathologica. 101: 285-93. PMID 11307630  0.44
2001 Iwata H, Tomita T, Maruyama K, Iwatsubo T. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2. The Journal of Biological Chemistry. 276: 21678-85. PMID 11283011 DOI: 10.1074/jbc.M007989200  1
2001 Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/jbc.M008511200  1
2001 Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Biochemical and Biophysical Research Communications. 282: 96-102. PMID 11263977 DOI: 10.1006/bbrc.2001.4558  1
2001 Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. Febs Letters. 489: 46-50. PMID 11231011 DOI: 10.1016/S0014-5793(00)02431-5  1
2000 Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356  1
2000 Pickering-Brown S, Baker M, Yen SH, Liu WK, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, et al. Pick's disease is associated with mutations in the tau gene. Annals of Neurology. 48: 859-67. PMID 11117542  0.44
2000 Wakabayashi K, Shibasaki Y, Hasegawa M, Horikawa Y, Soma Y, Hayashi S, Morita T, Iwatsubo T, Takahashi H. Primary progressive aphasia with focal glial tauopathy. Neuropathology and Applied Neurobiology. 26: 477-81. PMID 11054189  0.44
2000 Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American Journal of Pathology. 157: 331-9. PMID 10880403  1
2000 Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N. Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology. 54: 1787-95. PMID 10802785  0.44
2000 Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, et al. A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto) Annals of Neurology. 47: 422-9. PMID 10762152 DOI: 10.1002/1531-8249(200004)47:4<422::AID-ANA4>3.0.CO;2-G  1
2000 Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T. Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. The Journal of Biological Chemistry. 275: 11164-73. PMID 10753923 DOI: 10.1074/jbc.275.15.11164  1
2000 Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. The Journal of Biological Chemistry. 275: 17136-42. PMID 10748144 DOI: 10.1074/jbc.M909624199  1
2000 Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. International Journal of Molecular Medicine. 5: 269-73. PMID 10677567  1
2000 Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi H. Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology. Acta Neuropathologica. 99: 331-6. PMID 10663979  0.44
2000 Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C. Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. The Journal of Biological Chemistry. 275: 390-7. PMID 10617630  0.36
1999 Jakes R, Crowther RA, Lee VM, Trojanowski JQ, Iwatsubo T, Goedert M. Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein. Neuroscience Letters. 269: 13-6. PMID 10821633 DOI: 10.1016/S0304-3940(99)00411-5  1
1999 Tomita T, Iwatsubo T. [Molecular cell biology of presenilins]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 114: 337-46. PMID 10672594  1
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10627-34. PMID 10594046  1
1999 Wang GH, Mitsui K, Kotliarova S, Yamashita A, Nagao Y, Tokuhiro S, Iwatsubo T, Kanazawa I, Nukina N. Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells. Neuroreport. 10: 2435-8. PMID 10574348  1
1999 Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T. Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42. Neuroreport. 10: 2965-9. PMID 10549806  1
1999 Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H. Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans. Neuroscience Letters. 273: 203-7. PMID 10515194  1
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... ... Iwatsubo T, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/jbc.274.40.28669  1
1999 McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/nbdi.1999.0243  1
1999 Lee JA, Homma H, Tashiro K, Iwatsubo T, Imai K. D-aspartate localization in the rat pituitary gland and retina. Brain Research. 838: 193-9. PMID 10446332  0.44
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6538-48. PMID 10414982  1
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880  1
1997 Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport. 8: 2797-801. PMID 9295120  1
1996 Kanemaru K, Iwatsubo T, Ihara Y. Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain. Neuroscience Letters. 214: 196-8. PMID 8878117  0.48
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Lewy bodies: purification from diffuse Lewy body disease brains. Annals of the New York Academy of Sciences. 786: 195-205. PMID 8687019  0.48
1996 Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman ML, Rossor MN. Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. The American Journal of Pathology. 148: 1257-66. PMID 8644866  0.48
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. The American Journal of Pathology. 148: 1517-29. PMID 8623921  0.48
1996 Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T. Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. The American Journal of Pathology. 148: 259-65. PMID 8546214  0.48
1995 Mann DM, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathologica. 90: 472-7. PMID 8560980  0.48
1995 Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron. 14: 457-66. PMID 7857653  0.48
1995 Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Annals of Neurology. 37: 294-9. PMID 7695229 DOI: 10.1002/ana.410370305  0.48
1995 Mann DM, Pickering-Brown SM, Siddons MA, Iwatsubo T, Ihara Y, Asami-Odaka A, Suzuki N. The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype. Neuroscience Letters. 196: 105-8. PMID 7501233  0.48
1994 Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y. High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. The American Journal of Pathology. 145: 452-60. PMID 8053502  0.48
1994 Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13: 45-53. PMID 8043280 DOI: 10.1016/0896-6273(94)90458-8  1
1994 Iwatsubo T, Hasegawa M, Ihara Y. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathologica. 88: 129-36. PMID 7985493  0.48
1992 Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y. Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. The American Journal of Pathology. 140: 277-82. PMID 1310831  0.48
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