Takeshi Iwatsubo, MD - Publications

Affiliations: 
Neuropathology and Neuroscience The University of Tokyo 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=45
Website:
http://www.sss.jst.go.jp/english/researcher/h19-02iwatsubo.html

331 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kishino Y, Matsukawa K, Matsumoto T, Miyazaki R, Wakabayashi T, Nonaka T, Kametani F, Hasegawa M, Hashimoto T, Iwatsubo T. Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration. The Journal of Biological Chemistry. 102191. PMID 35753345 DOI: 10.1016/j.jbc.2022.102191  0.547
2022 Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. Iscience. 25: 103869. PMID 35243232 DOI: 10.1016/j.isci.2022.103869  0.677
2022 Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. The Journal of Experimental Medicine. 219. PMID 35212707 DOI: 10.1084/jem.20211275  0.604
2021 An H, Litscher G, Watanabe N, Wei W, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity. Neurobiology of Disease. 162: 105585. PMID 34915152 DOI: 10.1016/j.nbd.2021.105585  0.57
2021 Matsukawa K, Kukharsky MS, Park SK, Park S, Watanabe N, Iwatsubo T, Hashimoto T, Liebman SW, Shelkovnikova TA. Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy. Rna Biology. 1-9. PMID 33427561 DOI: 10.1080/15476286.2020.1860580  0.583
2020 Hashimoto T, Fujii D, Naka Y, Kashiwagi-Hakozaki M, Matsuo Y, Matsuura Y, Wakabayashi T, Iwatsubo T. Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques. Acta Neuropathologica Communications. 8: 212. PMID 33287899 DOI: 10.1186/s40478-020-01075-5  0.641
2020 Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, ... ... Iwatsubo T, et al. Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Acta Neuropathologica Communications. 8: 67. PMID 32398151 DOI: 10.1186/S40478-020-00936-3  0.639
2020 Kuwahara T, Iwatsubo T. The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System. Frontiers in Neuroscience. 14: 227. PMID 32256311 DOI: 10.3389/fnins.2020.00227  0.324
2020 Suzuki K, Hirakawa A, Ihara R, Iwata A, Ishii K, Ikeuchi T, Sun CK, Donohue M, Iwatsubo T. Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 6: e12007. PMID 32211510 DOI: 10.1002/Trc2.12007  0.338
2019 Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T. Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. Cell Reports. 29: 4362-4376.e6. PMID 31875546 DOI: 10.1016/J.Celrep.2019.11.112  0.567
2019 Tanaka Y, Yamada K, Satake K, Nishida I, Heuberger M, Kuwahara T, Iwatsubo T. Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis. Frontiers in Neuroscience. 13: 1258. PMID 31824253 DOI: 10.3389/fnins.2019.01258  0.337
2019 Yagi T, Kanekiyo M, Ito J, Ihara R, Suzuki K, Iwata A, Iwatsubo T, Aoshima K. Identification of prognostic factors to predict cognitive decline of patients with early Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative study. Alzheimer's & Dementia (New York, N. Y.). 5: 364-373. PMID 31440579 DOI: 10.1016/j.trci.2019.06.004  0.336
2019 Sato K, Mano T, Matsuda H, Senda M, Ihara R, Suzuki K, Arai H, Ishii K, Ito K, Ikeuchi T, Kuwano R, Toda T, Iwatsubo T, Iwata A. Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis. Neuroimage. Clinical. 24: 101957. PMID 31400633 DOI: 10.1016/j.nicl.2019.101957  0.336
2019 Park S, Park SK, Watanabe N, Hashimoto T, Iwatsubo T, Shelkovnikova TA, Liebman SW. Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies. Plos Genetics. 15: e1008308. PMID 31390360 DOI: 10.1371/Journal.Pgen.1008308  0.633
2019 Eto M, Hashimoto T, Shimizu T, Iwatsubo T. Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils. Plos One. 14: e0219465. PMID 31291354 DOI: 10.1371/Journal.Pone.0219465  0.649
2019 Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 14: 15. PMID 30975165 DOI: 10.1186/S13024-019-0315-7  0.625
2019 Sato K, Mano T, Ihara R, Suzuki K, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Iwatsubo T, Toda T, Iwata A, et al. Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer's Disease in the Japanese Alzheimer's Disease Neuroimaging Initiative. Journal of Alzheimer's Disease : Jad. PMID 30814351 DOI: 10.3233/JAD-181115  0.317
2019 Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A. Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 9: 2827. PMID 30808940 DOI: 10.1038/S41598-019-39494-7  0.654
2019 Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T, Initiative JADN. P4-231: Clinical And Cognitive Characteristics Of Participants With Preclinical Alzheimer'S Disease In The Japanese Alzheimer'S Disease Neuroimaging Initiative Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3894  0.328
2019 Sato K, Ihara R, Iwatsubo T, Suzuki K, Iwata A. P3‐300: Lower Serum Calcium As A Potentially Associated Factor For Conversion Of Mild Cognitive Impairment To Early Alzheimer'S Disease In Japanese Alzheimer'S Disease Neuroimaging Initiatives Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3331  0.314
2018 Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T. Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort. Alzheimer's & Dementia (New York, N. Y.). 4: 645-651. PMID 30511010 DOI: 10.1016/j.trci.2018.10.004  0.335
2018 Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A. Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease. Acta Neuropathologica. PMID 29770843 DOI: 10.1007/S00401-018-1866-3  0.661
2018 Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Sun CK, Beckett LA, Petersen RC, et al. Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29753531 DOI: 10.1016/J.Jalz.2018.03.009  0.325
2018 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ and brain Aβ deposition . The Journal of Biological Chemistry. 293: 7267. PMID 29752420 DOI: 10.1074/jbc.AAC118.003576  0.655
2018 Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Human Molecular Genetics. PMID 29425337 DOI: 10.1093/Hmg/Ddy046  0.617
2018 Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184  0.56
2018 Bannai T, Iwata A, Mano T, Ohtomo R, Ohtomo G, Hashimoto T, Iwatsubo T, Toda T. P2-070: Chronic Cerebral Hypoperfusion Increases Amyloid Plaques By Accelerating Amyloid Beta Aggregation In App/Ps1 Transgenic Mice Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.755  0.654
2018 Okada Y, Iwata K, Kato T, Kimura Y, Kizawa G, Nakamura A, Hattori H, Toyama H, Matsuda H, Ito K, Iwatsubo T, Initiative JADN. P3-448: The Effect Of Age And Sex On Evaluation Of Hippocampal Atrophy In Normal And Mild Alzheimer'S Disease Dementia: A J-Adni Study Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1811  0.329
2017 Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T. Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology. Biochemical and Biophysical Research Communications. PMID 29223392 DOI: 10.1016/j.bbrc.2017.12.024  0.302
2017 Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, ... ... Iwatsubo T, et al. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042514 DOI: 10.1073/Pnas.1707151114  0.662
2017 Miyagawa T, Iwatsubo T. [Toward Preclinical Trials for Alzheimer's Disease]. Brain and Nerve = Shinkei Kenkyu No Shinpo. 69: 711-722. PMID 28739984 DOI: 10.11477/mf.1416200812  0.343
2017 Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, et al. [DIAN/DIAN-J/DIAN-TU]. Brain and Nerve = Shinkei Kenkyu No Shinpo. 69: 701-709. PMID 28739983 DOI: 10.11477/Mf.1416200811  0.332
2017 Tagami S, Yanagida K, Ikeuchi T, Iwatsubo T, Waragai M, Ikeda M, Okochi M. CAN A BLOOD-BASED Aβ42 SURROGATE MARKER BE PRACTICALLY USED FOR SCREENING OF BRAIN Aβ42 ACCUMULATION? Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.1416  0.319
2016 Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T. Familial ALS-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila Melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. The Journal of Biological Chemistry. PMID 27634045 DOI: 10.1074/Jbc.M116.729152  0.6
2016 Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T. Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo. Human Molecular Genetics. PMID 27466196 DOI: 10.1093/hmg/ddw239  0.569
2016 Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human Molecular Genetics. PMID 27179792 DOI: 10.1093/Hmg/Ddw146  0.568
2016 Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/Srep23969  0.629
2016 Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1362-72. PMID 26818522 DOI: 10.1523/JNEUROSCI.5090-14.2016  0.555
2016 Iwata A, Mano T, Ohtomo R, Nagata K, Saido TC, Yamashita S, Ushijima T, Hashimoto T, Iwatsubo T, Tamaoka A, Tsuji S. Neuron-Specific Methylome Analysis Reveals New Pathomechanism In Alzheimer’S Disease Brains Alzheimers & Dementia. 12: 240. DOI: 10.1016/J.Jalz.2016.06.427  0.599
2016 Mano T, Ohtomo R, Nagata K, Murayama S, Saido TC, Yamashita S, Ushijima T, Hashimoto T, Tamaoka A, Iwatsubo T, Tsuji S, Iwata A. P2-073: Epigenetic Regulation of BRCA1 in Alzheimer’S Disease: Evaluation of Postmortem Brain and Model Mice Reveals Importance of Aggregated TAU Alzheimer's & Dementia. 12: P635-P636. DOI: 10.1016/J.Jalz.2016.06.1278  0.627
2015 Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DM, Iwatsubo T, Hasegawa M. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathologica. PMID 26538150 DOI: 10.1007/S00401-015-1503-3  0.369
2015 Hendrix JA, Finger B, Weiner MW, Frisoni GB, Iwatsubo T, Rowe CC, Kim SY, Guinjoan SM, Sevlever G, Carrillo MC. The Worldwide Alzheimer's Disease Neuroimaging Initiative: An update. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 850-9. PMID 26194318 DOI: 10.1016/J.Jalz.2015.05.008  0.32
2015 Doody RS, Raman R, Sperling RA, Seimers E, Sethuraman G, Mohs R, Farlow M, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS. Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer's disease. Alzheimer's Research & Therapy. 7: 36. PMID 26064192 DOI: 10.1186/S13195-015-0121-6  0.345
2015 Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T. Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease. Cell Reports. 11: 859-65. PMID 25937280 DOI: 10.1016/J.Celrep.2015.04.017  0.643
2015 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of Biological Chemistry. 290: 15163-74. PMID 25918154 DOI: 10.1074/Jbc.M114.622209  0.71
2015 Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Molecular Neurodegeneration. 10: 20. PMID 25888396 DOI: 10.1186/S13024-015-0014-Y  0.615
2015 Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T. Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2646-56. PMID 25673856 DOI: 10.1523/JNEUROSCI.3164-14.2015  0.5
2015 Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T. Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity. Biochemical and Biophysical Research Communications. 457: 194-9. PMID 25545059 DOI: 10.1016/j.bbrc.2014.12.087  0.559
2015 Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H. Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Human Molecular Genetics. 24: 540-58. PMID 25231903 DOI: 10.1093/hmg/ddu475  0.399
2015 Tomita T, Kidana K, Tatebe T, Ouchi Y, Akishita M, Iwatsubo T. Pathophysiological impact of astrocyte-derived kallikrein-related peptidase 7 on Aβ metabolism in brain Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.594  0.474
2014 Villemagne VL, Kim SY, Rowe CC, Iwatsubo T. Imago Mundi, Imago AD, Imago ADNI. Alzheimer's Research & Therapy. 6: 62. PMID 25478022 DOI: 10.1186/s13195-014-0062-5  0.356
2014 Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, ... ... Iwatsubo T, et al. Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America. 111: 10544-9. PMID 25009180 DOI: 10.1073/Pnas.1402171111  0.505
2014 Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T. New photocleavable linker: α-thioacetophenone-type linker. Bioorganic & Medicinal Chemistry Letters. 24: 2831-3. PMID 24841630 DOI: 10.1016/J.Bmcl.2014.04.104  0.433
2014 Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T. Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nature Communications. 5: 3386. PMID 24577224 DOI: 10.1038/ncomms4386  0.564
2014 Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1370-9. PMID 24453327 DOI: 10.1523/Jneurosci.2440-13.2014  0.584
2014 Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. The New England Journal of Medicine. 370: 311-21. PMID 24450890 DOI: 10.1056/Nejmoa1312889  0.345
2014 Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Molecular Neurodegeneration. 9: 7. PMID 24410857 DOI: 10.1186/1750-1326-9-7  0.537
2014 Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M. Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation. Angewandte Chemie (International Ed. in English). 53: 1382-5. PMID 24339209 DOI: 10.1002/anie.201308001  0.513
2014 Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/J.Str.2013.09.018  0.562
2014 Miyagawa T, Morohashi Y, Ojima R, Tsuji S, Iwatsubo T, Tomita T. Bin1 Regulates Bace1 Trafficking And Ab Production Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.314  0.421
2014 Tomita T, Tominaga A, Takagi-Niidome S, Iwatsubo T. Conformational Changes In The Transmembrane Domains 4 And 5 Of Presenilin 1 Associated With Altered Abeta42 Production Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.1113  0.484
2013 Iwatsubo T. [Current status and perspectives on the development of AD therapeutics based on amyloid cascade hypothesis]. Rinshå Shinkeigaku = Clinical Neurology. 53: 1039. PMID 24291872 DOI: DN/JST.JSTAGE/clinicalneurol/53.1039  0.357
2013 Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956  0.614
2013 Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T. Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. Bmc Biochemistry. 14: 16. PMID 23829174 DOI: 10.1186/1471-2091-14-16  0.473
2013 Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T. RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Human Molecular Genetics. 22: 4474-84. PMID 23804749 DOI: 10.1093/Hmg/Ddt296  0.59
2013 Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. Plos One. 8: e64050. PMID 23667698 DOI: 10.1371/journal.pone.0064050  0.552
2013 Tomita T, Iwatsubo T. Structural biology of presenilins and signal peptide peptidases. The Journal of Biological Chemistry. 288: 14673-80. PMID 23585568 DOI: 10.1074/jbc.R113.463281  0.505
2013 Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T. Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study. Annals of Nuclear Medicine. 27: 452-9. PMID 23483370 DOI: 10.1007/s12149-013-0704-x  0.308
2013 Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T. Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition. Journal of Medicinal Chemistry. 56: 1443-54. PMID 23342950 DOI: 10.1021/Jm301306C  0.498
2013 Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T. Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry. 52: 61-9. PMID 23210549 DOI: 10.1021/bi301252r  0.508
2013 Takasugi N, Sasaki T, Tomita T, Iwatsubo T. FTY720/Fingolimod, a sphingosine analogue, reduces beta-amyloid production in neurons Alzheimers & Dementia. 9: 184. DOI: 10.1016/J.Jalz.2013.05.311  0.559
2013 Hashimoto T, Kunugi H, Matsukawa K, Uchigami H, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T. Two distinct pathways leading to retinal degeneration in transgenic Drosophila melanogaster overexpressing human FUS Alzheimers & Dementia. 9: 170. DOI: 10.1016/J.Jalz.2013.05.269  0.641
2013 Tomita T, Suzuki K, Shiohara A, Osawa S, Iwatsubo T. Pathophysiological role of proteolytic cleavage of neuroligins Alzheimers & Dementia. 9: 144. DOI: 10.1016/J.Jalz.2013.04.097  0.43
2013 Iwata A, Iwatsubo T. Disease-modifying therapy for Alzheimer's disease: Challenges and hopes Neurology and Clinical Neuroscience. 1: 49-54. DOI: 10.1002/Ncn3.20  0.322
2012 Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, ... ... Iwatsubo T, et al. Activity-dependent proteolytic cleavage of neuroligin-1. Neuron. 76: 410-22. PMID 23083742 DOI: 10.1016/J.Neuron.2012.10.003  0.467
2012 Takeo K, Watanabe N, Tomita T, Iwatsubo T. Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein. The Journal of Biological Chemistry. 287: 25834-43. PMID 22689582 DOI: 10.1074/jbc.M111.336347  0.508
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Iwatsubo T, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.491
2012 Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T. Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans. The Journal of Biological Chemistry. 287: 7098-109. PMID 22232559 DOI: 10.1074/jbc.M111.237131  0.332
2012 Ito G, Iwatsubo T. Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form. The Biochemical Journal. 441: 987-94. PMID 22047502 DOI: 10.1042/BJ20111215  0.309
2012 Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, ... Iwatsubo T, et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 31: 787-98. PMID 21725355 DOI: 10.1038/Onc.2011.265  0.48
2012 Tomita T, Morohashi Y, Kanatsu K, Iwatsubo T. PICALM regulates Aβ42 production by modulation of gamma-secretase trafficking Alzheimers & Dementia. 8: 312. DOI: 10.1016/J.Jalz.2012.05.857  0.493
2012 Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Sugishita M, Kuwano R, Iwatsubo T. Effects of APOE-ε4 on regional cerebral amyloid deposition and glucose metabolism in amnestic mild cognitive impairment with amyloid pathology confirmed by PiB-PET: Results from J-ADNI Alzheimers & Dementia. 8: 686. DOI: 10.1016/J.Jalz.2012.05.2181  0.322
2012 Ishii K, Haneda E, Sakata M, Oda K, Toyohara J, Ishiwata K, Senda M, Ito K, Kuwano R, Iwatsubo T. Influence of APOE-ɛ4 genotype on global and regional Aβ deposition: Results from three WW-ADNI [C-11]PiB data studies Alzheimers & Dementia. 8: 56. DOI: 10.1016/J.Jalz.2012.05.130  0.313
2012 Ishii K, Haneda E, Sakata M, Oda K, Toyohara J, Ishiwata K, Senda M, Ito K, Kuwano R, Iwatsubo T. Influence of APOE genotype on global and regional amyloid deposition: Results from three WW-ADNI [C-11]PiB data Alzheimers & Dementia. 8: 454. DOI: 10.1016/J.Jalz.2012.05.1210  0.322
2011 Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. The Journal of Biological Chemistry. 286: 44569-75. PMID 22074918 DOI: 10.1074/jbc.M111.270108  0.485
2011 Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The Embo Journal. 30: 4815-24. PMID 22002539 DOI: 10.1038/Emboj.2011.372  0.526
2011 Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T. Three-dimensional structure of the signal peptide peptidase. The Journal of Biological Chemistry. 286: 26188-97. PMID 21636854 DOI: 10.1074/jbc.M111.260273  0.471
2011 Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T. Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. Journal of Neurochemistry. 118: 407-15. PMID 21585370 DOI: 10.1111/J.1471-4159.2011.07311.X  0.621
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1016/J.Jalz.2011.05.1193  0.504
2011 Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 280-92. PMID 21514248 DOI: 10.1016/J.Jalz.2011.03.003  0.354
2011 Iwatsubo T. Alzheimer's disease: From molecular pathology to disease-modifying therapy Neuroscience Research. 71. DOI: 10.1016/J.Neures.2011.07.1828  0.321
2010 Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15943-50. PMID 21106832 DOI: 10.1523/JNEUROSCI.3318-10.2010  0.668
2010 Morohashi Y, Tomita T, Iwatsubo T. [Molecular targeted therapy in Alzheimer disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 68: 1906-10. PMID 20954338  0.509
2010 Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503  0.535
2010 Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M. Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. The Journal of Biological Chemistry. 285: 34885-98. PMID 20805224 DOI: 10.1074/jbc.M110.148460  0.387
2010 Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66. PMID 20720123 DOI: 10.1523/JNEUROSCI.2884-10.2010  0.57
2010 Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H. Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. Bioorganic & Medicinal Chemistry Letters. 20: 5282-5. PMID 20650635 DOI: 10.1016/j.bmcl.2010.06.131  0.438
2010 Iwatsubo T. Japanese Alzheimer's Disease Neuroimaging Initiative: present status and future. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 297-9. PMID 20451880 DOI: 10.1016/j.jalz.2010.03.011  0.36
2010 Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. The Journal of Biological Chemistry. 285: 19738-46. PMID 20418378 DOI: 10.1074/jbc.M110.101287  0.516
2010 Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK. Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Science Signaling. 3: ra22. PMID 20332427 DOI: 10.1126/Scisignal.2000818  0.349
2010 Ishii K, Sakata M, Oda K, Ishiwata K, Senda M, Ito K, Kuwano R, Iwatsubo T. The first results of amyloid imaging in Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) study Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.968  0.373
2010 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Corrigendum to "Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" [Bioorg. Med. Chem. Lett. 19 (2009) 6869] (DOI:10.1016/j.bmcl.2009.10.086) Bioorganic and Medicinal Chemistry Letters. 20: 1798-1799. DOI: 10.1016/J.Bmcl.2010.01.025  0.389
2009 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorganic & Medicinal Chemistry Letters. 19: 6869-71. PMID 19892551 DOI: 10.1016/J.Bmcl.2009.10.086  0.447
2009 Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Science. 100: 2444-50. PMID 19775286 DOI: 10.1111/j.1349-7006.2009.01328.x  0.426
2009 Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T. Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11393-8. PMID 19741145 DOI: 10.1523/Jneurosci.2021-09.2009  0.646
2009 Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/Jbc.M109.055061  0.526
2009 Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. Journal of the American Chemical Society. 131: 7353-9. PMID 19432477 DOI: 10.1021/ja9001458  0.552
2009 Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, ... Iwatsubo T, et al. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Molecular Psychiatry. 14: 1004-16. PMID 19204726 DOI: 10.1038/Mp.2009.10  0.334
2009 Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P. Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease. Human Molecular Genetics. 18: 872-87. PMID 19074459 DOI: 10.1093/Hmg/Ddn417  0.323
2009 Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/Jbc.M806380200  0.571
2009 Iwatsubo T. Alzheimer disease: From basic study to disease-modifying therapy Neuroscience Research. 65. DOI: 10.1016/J.Neures.2009.09.1482  0.304
2009 Tomita T, Hayashi I, Takatori S, Urano Y, Iwanari H, Kodama T, Hamakubo T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the γ-secretase activity Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.225  0.433
2009 Takatori S, Hayashi I, Urano Y, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Intrabody against immature nicastrin disrupts the proper folding and the glycosyl maturation of the extracellular domain of nicastrin Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.504  0.442
2009 Miyashita H, Maruyama Y, Ogura T, Mio K, Iwatsubo T, Tomita T, Sato C. Three dimensional structure of signal peptide peptidase Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.503  0.426
2008 Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry. 283: 34554-62. PMID 18940800 DOI: 10.1074/Jbc.M801487200  0.629
2008 Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL. Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 23: 996-1001. PMID 18608784 DOI: 10.1080/14756360701832706  0.505
2008 Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/J.Neuron.2008.04.015  0.486
2008 Sato C, Takagi S, Tomita T, Iwatsubo T. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6264-71. PMID 18550769 DOI: 10.1523/JNEUROSCI.1163-08.2008  0.66
2008 Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan CF, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A. Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia. Archives of Neurology. 65: 514-9. PMID 18413475 DOI: 10.1001/archneur.65.4.514  0.301
2008 Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell & Melanoma Research. 21: 70-8. PMID 18353145 DOI: 10.1111/j.1755-148X.2007.00423.x  0.446
2008 Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neuro-Degenerative Diseases. 5: 222-4. PMID 18322396 DOI: 10.1159/000113708  0.347
2008 Akanuma S, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T. ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier. Neurochemistry International. 52: 956-61. PMID 18201804 DOI: 10.1016/J.Neuint.2007.12.002  0.616
2008 Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K. Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro. Journal of Biochemistry. 143: 475-86. PMID 18174189 DOI: 10.1093/Jb/Mvm239  0.606
2008 Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H. Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Experimental Neurology. 210: 409-20. PMID 18164295 DOI: 10.1016/j.expneurol.2007.11.019  0.405
2008 Takatori S, Ito G, Iwatsubo T. Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. Neuroscience Letters. 430: 13-7. PMID 18031932 DOI: 10.1016/j.neulet.2007.10.019  0.312
2008 Tomita T, Sato C, Takagi S, Iwatsubo T. O4-03-03: C-terminal PAL motif of presenilin 1 comprises the subsite of gamma-secretase within the catalytic pore Alzheimer's & Dementia. 4: T189-T189. DOI: 10.1016/j.jalz.2008.05.520  0.61
2008 Watanabe N, Tomita T, Iwatsubo T. P4-211: The functional roles of transmembrane domains of presenilin 1 in the formation of active gamma-secretase complex Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2279  0.479
2008 Takagi S, Sato C, Tomita T, Iwatsubo T. P4-208: Transmembrane domain 1 of presenilin 1 contributes to the formation of the catalytic pore of gamma-secretase Alzheimer's & Dementia. 4: T732-T732. DOI: 10.1016/j.jalz.2008.05.2276  0.63
2008 Sugimoto Y, Fuwa H, Yokoshima S, Fukuyama T, Sasaki M, Tomita T, Iwatsubo T. P4-207: Chemical biological analysis of gamma-secretase using arylsulfonamide-type inhibitors Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2275  0.446
2008 Takasugi N, Suzuki K, Isshiki H, Tomita T, Iwatsubo T. P3-348: Neuron-specific regulation of beta-secretase activity by sphingosine kinase Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1917  0.476
2008 Hori Y, Hashimoto T, Nomoto H, Iwatsubo T. P1-478: Isoform-specific effects of apolipoprotein E on the stability of Abeta protofibrils Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1061  0.609
2007 Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13092-7. PMID 18045903 DOI: 10.1523/JNEUROSCI.4244-07.2007  0.43
2007 Haleem K, Lippa CF, Smith TW, Kowa H, Wu J, Iwatsubo T. Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins. American Journal of Alzheimer's Disease and Other Dementias. 22: 137-44. PMID 17545141 DOI: 10.1177/1533317506298051  0.414
2007 Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T. Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation. Analytical Chemistry. 79: 4887-91. PMID 17536782 DOI: 10.1021/Ac0701482  0.655
2007 Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. Acs Chemical Biology. 2: 408-18. PMID 17530731 DOI: 10.1021/Cb700073Y  0.468
2007 Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Organic Letters. 9: 2055-8. PMID 17480083 DOI: 10.1021/Ol070376I  0.462
2007 Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M. Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein. Journal of Neuroscience Research. 85: 1819-25. PMID 17465029 DOI: 10.1002/jnr.21310  0.301
2007 Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. The Journal of Biological Chemistry. 282: 12388-96. PMID 17329245 DOI: 10.1074/jbc.M611549200  0.694
2007 Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. The Journal of Biological Chemistry. 282: 4916-23. PMID 17170111 DOI: 10.1074/Jbc.M608220200  0.669
2007 Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Photoaffinity Probes for Alzheimer’s Disease Synfacts. 2007: 995-995. DOI: 10.1055/S-2007-968915  0.371
2007 Hayashi Y, Tomita T, Kopan R, Iwatsubo T. The role of Notch signaling in synaptogenesis Neuroscience Research. 58. DOI: 10.1016/J.Neures.2007.06.863  0.585
2006 Iwatsubo T. [Beta- and gamma-secretases]. Rinshå Shinkeigaku = Clinical Neurology. 46: 925-6. PMID 17432221  0.345
2006 Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 52: 831-43. PMID 17145504 DOI: 10.1016/J.Neuron.2006.10.035  0.651
2006 Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12081-8. PMID 17108181 DOI: 10.1523/JNEUROSCI.3614-06.2006  0.664
2006 Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochemical and Biophysical Research Communications. 351: 57-63. PMID 17054906 DOI: 10.1016/j.bbrc.2006.09.162  0.499
2006 Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min do S, Kim J, Paik SR, Chung KC. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. The Journal of Biological Chemistry. 281: 33250-7. PMID 16959772 DOI: 10.1074/jbc.M606147200  0.318
2006 Arawaka S, Wada M, Goto S, Karube H, Sakamoto M, Ren CH, Koyama S, Nagasawa H, Kimura H, Kawanami T, Kurita K, Tajima K, Daimon M, Baba M, Kido T, ... ... Iwatsubo T, et al. The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9227-38. PMID 16957079 DOI: 10.1523/Jneurosci.0341-06.2006  0.321
2006 Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration. 1: 2. PMID 16930449 DOI: 10.1186/1750-1326-1-2  0.533
2006 Sato C, Iwatsubo T. Focusing on beta-amyloid: report of the 35th Annual Meeting of the Society for Neuroscience. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 114-6. PMID 16911967 DOI: 10.1080/13506120600722738  0.571
2006 Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zolo P, Arima K, Iseki E, ... ... Iwatsubo T, et al. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathology and Applied Neurobiology. 32: 374-87. PMID 16866983 DOI: 10.1111/J.1365-2990.2006.00736.X  0.376
2006 Iwatsubo T, Ihara Y, Kanazawa I. Alzheimer disease research in Japan: public funding. Nature Medicine. 12: 778-9. PMID 16829946 DOI: 10.1038/nm0706-778  0.478
2006 Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quéléver G, Iwatsubo T, Kraus JL. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays. Journal of Medicinal Chemistry. 49: 4275-85. PMID 16821787 DOI: 10.1021/jm0602864  0.495
2006 Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharmaceutical Research. 23: 1407-16. PMID 16779710 DOI: 10.1007/S11095-006-0208-7  0.623
2006 Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 4184-9. PMID 16766183 DOI: 10.1016/J.Bmcl.2006.05.091  0.434
2006 Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T. Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters. 16: 3813-6. PMID 16682195 DOI: 10.1016/J.Bmcl.2006.04.025  0.432
2006 Tian J, Shi J, Smallman R, Iwatsubo T, Mann DM. Relationships in Alzheimer's disease between the extent of Abeta deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen. Neuropathology and Applied Neurobiology. 32: 332-40. PMID 16640651 DOI: 10.1111/J.1365-2990.2006.00732.X  0.323
2006 Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of Biological Chemistry. 281: 14670-6. PMID 16569643 DOI: 10.1074/Jbc.M513012200  0.657
2006 de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, ... ... Iwatsubo T, et al. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathologica. 111: 329-40. PMID 16552612 DOI: 10.1007/S00401-006-0048-X  0.315
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158  0.625
2006 Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, et al. Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype. Journal of Neurology, Neurosurgery, and Psychiatry. 77: 515-7. PMID 16543533 DOI: 10.1136/Jnnp.2005.063917  0.395
2006 Bensemain F, Chapuis J, Tian J, Shi J, Thaker U, Lendon C, Iwatsubo T, Amouyel P, Mann D, Lambert JC. Association study of the Ubiquilin gene with Alzheimer's disease. Neurobiology of Disease. 22: 691-3. PMID 16504527 DOI: 10.1016/J.Nbd.2006.01.007  0.336
2006 Tomita T, Iwatsubo T. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current Pharmaceutical Design. 12: 661-70. PMID 16472155 DOI: 10.2174/138161206775474206  0.583
2006 Shi J, Tian J, Pritchard A, Lendon C, Lambert JC, Iwatsubo T, Mann DM. A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathologica. 111: 15-20. PMID 16328515 DOI: 10.1007/S00401-005-1108-3  0.389
2006 Kuwahara T, Koyama A, Gengyo-Ando K, Masuda M, Kowa H, Tsunoda M, Mitani S, Iwatsubo T. Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. The Journal of Biological Chemistry. 281: 334-40. PMID 16260788 DOI: 10.1074/jbc.M504860200  0.302
2006 Hashimoto T, Fujii D, Matsuo Y, Matsuura Y, Westaway D, Iwatsubo T. P1-114: Pathological effects of CLAC in the brains of APP/CLAC-P double transgenic mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.490  0.599
2006 Tomita T, Takahashi Y, Fuwa H, Konno Y, Morohashi Y, Kan T, Sugimoto Y, Fukuyama T, Sasaki M, Natsugari H, Iwatsubo T. O1-02-07 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.259  0.467
2006 Yamada K, Yabuki C, Tachikawa M, Ohtsuki S, Strickland DK, Bu G, Terasaki T, Hashimoto T, Iwatsubo T. AbstractPoster presentation: Wednesday posterP4-069: Modeling amyloid β-peptide transport across the blood-brain barrier in TR-BBB cells Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1807  0.601
2006 Sato C, Watanabe N, Morohashi Y, Tomita T, Iwatsubo T. P3-416: Probing the structural changes of presenilin 1 by substituted-cysteine accessibility method Alzheimer's & Dementia. 2: S498-S498. DOI: 10.1016/j.jalz.2006.05.1687  0.593
2006 Hayashi I, Urano Y, Iwanari H, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. P3-412: Generation of monoclonal antibodies against the extracellular domain of nicastrin Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1683  0.424
2006 Tian J, Shi J, Smallman R, Iwatsubo T, Mann D. P3-185: Relationships in Alzheimer’s disease between the extent of Aβ deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1453  0.326
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025  0.599
2006 Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M. Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates Heterocycles. 70: 101-106. DOI: 10.1002/CHIN.200722128  0.396
2005 Iwatsubo T. [Molecular pathology and therapeutic perspectives of Alzheimer's disease]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 42: 651-4. PMID 16408507 DOI: 10.3143/Geriatrics.42.651  0.353
2005 Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. The Journal of Biological Chemistry. 280: 41967-75. PMID 16234244 DOI: 10.1074/jbc.M509066200  0.651
2005 Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, ... ... Iwatsubo T, et al. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2069-71. PMID 16204356 DOI: 10.1096/Fj.05-3744Fje  0.45
2005 Pritchard A, Harris J, Pritchard CW, St Clair D, Lemmon H, Lambert JC, Chartier-Harlin MC, Hayes A, Thaker U, Iwatsubo T, Mann DM, Lendon C. Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease. Neuroscience Letters. 382: 221-6. PMID 15925094 DOI: 10.1016/J.Neulet.2005.03.016  0.382
2005 Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma-secretase complex with lipid rafts. Journal of Lipid Research. 46: 904-12. PMID 15716592 DOI: 10.1194/jlr.M400333-JLR200  0.549
2005 Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. The Journal of Biological Chemistry. 280: 12967-75. PMID 15644323 DOI: 10.1074/jbc.M409829200  0.522
2005 Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T. CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. The Journal of Biological Chemistry. 280: 8596-605. PMID 15615705 DOI: 10.1074/Jbc.M413340200  0.681
2005 Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. The Journal of Biological Chemistry. 280: 7614-23. PMID 15611092 DOI: 10.1074/Jbc.M408714200  0.358
2004 Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H. Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease. Journal of Neurochemistry. 91: 451-61. PMID 15447678 DOI: 10.1111/j.1471-4159.2004.02728.x  0.319
2004 Tomita T, Iwatsubo T. [Recent advances in Alzheimer's disease-related gamma-secretase complex]. Seikagaku. the Journal of Japanese Biochemical Society. 76: 666-70. PMID 15346905  0.449
2004 Tomita T, Iwatsubo T. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease. Drug News & Perspectives. 17: 321-5. PMID 15334182 DOI: 10.1358/dnp.2004.17.5.829036  0.573
2004 Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. The Journal of Biological Chemistry. 279: 38040-6. PMID 15215237 DOI: 10.1074/jbc.M405597200  0.516
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American Journal of Pathology. 165: 273-81. PMID 15215182 DOI: 10.1016/S0002-9440(10)63295-6  0.664
2004 Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K. Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 75: 1039-42. PMID 15201367 DOI: 10.1136/jnnp.2003.010611  0.393
2004 Iwatsubo T. The gamma-secretase complex: machinery for intramembrane proteolysis. Current Opinion in Neurobiology. 14: 379-83. PMID 15194119 DOI: 10.1016/j.conb.2004.05.010  0.396
2004 Zhang Y, Hayes A, Pritchard A, Thaker U, Haque MS, Lemmon H, Harris J, Cumming A, Lambert JC, Chartier-Harlin MC, St Clair D, Iwatsubo T, Mann DM, Lendon CL. Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease. Neuroscience Letters. 362: 99-102. PMID 15193763 DOI: 10.1016/J.Neulet.2004.03.008  0.349
2004 Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice. The European Journal of Neuroscience. 19: 2826-38. PMID 15147316 DOI: 10.1111/j.0953-816X.2004.03397.x  0.558
2004 Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, ... ... Iwatsubo T, et al. Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. Neuromolecular Medicine. 5: 133-46. PMID 15075440 DOI: 10.1385/Nmm:5:2:133  0.324
2004 Umeda Y, Taniguchi S, Arima K, Piao YS, Takahashi H, Iwatsubo T, Mann D, Hasegawa M. Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neuroscience Letters. 359: 151-4. PMID 15050686 DOI: 10.1016/J.Neulet.2004.01.060  0.32
2004 Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity. Bioorganic & Medicinal Chemistry Letters. 14: 1983-5. PMID 15050642 DOI: 10.1016/J.Bmcl.2004.01.067  0.413
2004 Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Molecular and Cellular Biology. 24: 2012-24. PMID 14966281 DOI: 10.1128/MCB.24.5.2012-2024.2004  0.444
2004 Taniguchi S, McDonagh AM, Pickering-Brown SM, Umeda Y, Iwatsubo T, Hasegawa M, Mann DM. The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathology and Applied Neurobiology. 30: 1-18. PMID 14720172 DOI: 10.1046/J.0305-1846.2003.00481.X  0.351
2004 Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM. Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective. The Journal of Biological Chemistry. 279: 4625-31. PMID 14627698 DOI: 10.1074/jbc.M310994200  0.323
2004 Fukumoto H, Kosaka T, Sagayama M, Kawamoto M, Tomita T, Terauchi J, Tarui N, Kakihana M, Iwatsubo T, Miyamoto M. P4-376 TAK-070, a non-peptidic bace inhibitor inhibits secretion of amyloid beta 40/42 and enhances sappalpha production in neuronal cell cultures Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81934-1  0.51
2004 Morohashi Y, Tominari Y, Watanabe N, Kan T, Fuwa H, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. P4-322 Presenilin-1 is a molecular target of a dipeptidic γ-secretase inhibitor, DAPT Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81880-3  0.439
2004 Lambert J, Mann D, Richard F, Tian J, Shi J, Thaker U, Merrot S, Harris J, Chartier-Harlin M, Sazdovitch V, Mohr M, Frigard B, Hauw J, Lendon C, Iwatsubo T, et al. P4-083 Is there a relation between APOE expression and amyloid depositions in the brain of Alzheimer's disease cases? Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81641-5  0.394
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Tsuji S, Mann DM, Hashimoto T, Iwatsubo T. P1-235 CLAC-positive senile plaques in Alzheimer brains: mutually exclusive distribution to Aβ40 and acquisition of protease resistance Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80548-7  0.633
2004 Tomita T, Niimura M, Hayashi I, Sato C, Tanaka S, Shinohara M, Takahashi Y, Morohashi Y, Iwatsubo T. O3-05-04 Roles of presenilin cofactors in the assembly and activity of {gamma}-secretase complex Neurobiology of Aging. 25: S62. DOI: 10.1016/S0197-4580(04)80209-4  0.614
2004 Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H. Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues Tetrahedron Letters. 45: 2323-2326. DOI: 10.1016/J.Tetlet.2004.01.087  0.408
2003 Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J. Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. Journal of Neuropathology and Experimental Neurology. 62: 1108-17. PMID 14656069 DOI: 10.1093/Jnen/62.11.1108  0.679
2003 Iwatsubo T. Aggregation of alpha-synuclein in the pathogenesis of Parkinson's disease. Journal of Neurology. 250: III11-4. PMID 14579119 DOI: 10.1007/s00415-003-1303-x  0.319
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  0.682
2003 Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I. Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8513-25. PMID 13679420 DOI: 10.1523/Jneurosci.23-24-08513.2003  0.519
2003 Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chemical Communications (Cambridge, England). 2244-5. PMID 13678222 DOI: 10.1039/B306970B  0.397
2003 Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S. Accumulation of phosphorylated alpha-synuclein in aging human brain. Journal of Neuropathology and Experimental Neurology. 62: 644-54. PMID 12834109 DOI: 10.1093/Jnen/62.6.644  0.306
2003 Lambert JC, Luedecking-Zimmer E, Merrot S, Hayes A, Thaker U, Desai P, Houzet A, Hermant X, Cottel D, Pritchard A, Iwatsubo T, Pasquier F, Frigard B, Conneally PM, Chartier-Harlin MC, et al. Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. Journal of Medical Genetics. 40: 424-30. PMID 12807963 DOI: 10.1136/Jmg.40.6.424  0.336
2003 Iwatsubo T. Molecular pathogenesis of Alzheimer's disease. Internal Medicine (Tokyo, Japan). 42: 312. PMID 12705809 DOI: 10.2169/Internalmedicine.42.312  0.343
2003 Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7  0.534
2003 Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 422: 438-41. PMID 12660785 DOI: 10.1038/Nature01506  0.557
2003 Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. The Journal of Biological Chemistry. 278: 18664-70. PMID 12637581 DOI: 10.1074/Jbc.M301619200  0.547
2003 Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298  0.44
2003 Thaker U, McDonagh AM, Iwatsubo T, Lendon CL, Pickering-Brown SM, Mann DM. Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, Abeta40, in sporadic and familial Alzheimer's disease. Neuropathology and Applied Neurobiology. 29: 35-44. PMID 12581338 DOI: 10.1046/J.1365-2990.2003.00425.X  0.417
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546  0.529
2002 Matsushita S, Arai H, Okamura N, Ohmori T, Takasugi K, Matsui T, Maruyama M, Iwatsubo T, Higuchi S. Clinical and biomarker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer's disease. Biological Psychiatry. 52: 907-10. PMID 12399144 DOI: 10.1016/S0006-3223(02)01386-0  0.365
2002 Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. The Journal of Biological Chemistry. 277: 50198-205. PMID 12388554 DOI: 10.1074/jbc.M205352200  0.544
2002 Hayes A, Thaker U, Iwatsubo T, Pickering-Brown SM, Mann DM. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience Letters. 331: 171-4. PMID 12383924 DOI: 10.1016/S0304-3940(02)00888-1  0.41
2002 Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/Emboj/Cdf541  0.578
2002 Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T. A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neuroscience Letters. 330: 84-8. PMID 12213640 DOI: 10.1016/S0304-3940(02)00616-X  0.349
2002 Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin MC, Iwatsubo T, Pickering-Brown SM, Mann DM. The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease. Neuroscience Letters. 328: 314-8. PMID 12147333 DOI: 10.1016/S0304-3940(02)00553-0  0.378
2002 Araria-Goumidi L, Lambert JC, Mann DM, Lendon C, Frigard B, Iwatsubo T, Cottel D, Amouyel P, Chartier-Harlin MC. Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 73: 62-4. PMID 12082048 DOI: 10.1136/Jnnp.73.1.62  0.408
2002 Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I. Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochemical and Biophysical Research Communications. 294: 429-40. PMID 12051730 DOI: 10.1016/S0006-291X(02)00498-9  0.345
2002 Tomita T, Katayama R, Takikawa R, Iwatsubo T. Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. Febs Letters. 520: 117-21. PMID 12044882 DOI: 10.1016/S0014-5793(02)02802-8  0.497
2002 Green EK, Thaker U, McDonagh AM, Iwatsubo T, Lambert JC, Chartier-Harlin MC, Harris JM, Pickering-Brown SM, Lendon CL, Mann DM. A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain. Neuroscience Letters. 324: 113-6. PMID 11988340 DOI: 10.1016/S0304-3940(02)00190-8  0.34
2002 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. The Embo Journal. 21: 1524-34. PMID 11927537 DOI: 10.1093/Emboj/21.7.1524  0.672
2002 Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H. Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Annals of Neurology. 51: 525-30. PMID 11921059 DOI: 10.1002/ana.10163  0.341
2002 Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. The Journal of Biological Chemistry. 277: 14965-75. PMID 11847232 DOI: 10.1074/jbc.M200897200  0.499
2002 Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biology. 4: 160-4. PMID 11813001 DOI: 10.1038/Ncb748  0.304
2001 Kahle PJ, Neumann M, Ozmen L, Müller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. The American Journal of Pathology. 159: 2215-25. PMID 11733371 DOI: 10.1016/S0002-9440(10)63072-6  0.333
2001 Lambert JC, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon C, Chartier-Harlin MC. Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet. 357: 608-9. PMID 11558492 DOI: 10.1016/S0140-6736(00)04063-0  0.302
2001 Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y. Tau accumulation in a patient with pallidonigroluysian atrophy. Neuroscience Letters. 309: 89-92. PMID 11502352 DOI: 10.1016/S0304-3940(01)02034-1  0.369
2001 Mann DM, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M, Kalimo H, Iwatsubo T. Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques. Neuropathology and Applied Neurobiology. 27: 189-96. PMID 11489138 DOI: 10.1046/J.1365-2990.2001.00316.X  0.432
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  0.698
2001 Mann DM, Pickering-Brown SM, Takeuchi A, Iwatsubo T. Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease. The American Journal of Pathology. 158: 2165-75. PMID 11395394 DOI: 10.1016/S0002-9440(10)64688-3  0.439
2001 Lambert JC, Mann DM, Harris JM, Chartier-Harlin MC, Cumming A, Coates J, Lemmon H, StClair D, Iwatsubo T, Lendon C. The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain. Journal of Medical Genetics. 38: 353-5. PMID 11389157 DOI: 10.1136/Jmg.38.6.353  0.384
2001 Verkkoniemi A, Kalimo H, Paetau A, Somer M, Iwatsubo T, Hardy J, Haltia M. Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype. Journal of Neuropathology and Experimental Neurology. 60: 483-92. PMID 11379823 DOI: 10.1093/Jnen/60.5.483  0.42
2001 Mann DM, McDonagh AM, Pickering-Brown SM, Kowa H, Iwatsubo T. Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype. Neuroscience Letters. 304: 161-4. PMID 11343827 DOI: 10.1016/S0304-3940(01)01785-2  0.381
2001 Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T. Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis. Annals of Neurology. 49: 501-11. PMID 11310628 DOI: 10.1002/Ana.100  0.336
2001 Piao YS, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi H. Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathologica. 101: 285-93. PMID 11307630 DOI: 10.1007/S004010000292  0.323
2001 Iwata H, Tomita T, Maruyama K, Iwatsubo T. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2. The Journal of Biological Chemistry. 276: 21678-85. PMID 11283011 DOI: 10.1074/jbc.M007989200  0.547
2001 Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/Jbc.M008511200  0.49
2001 Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Biochemical and Biophysical Research Communications. 282: 96-102. PMID 11263977 DOI: 10.1006/bbrc.2001.4558  0.447
2001 Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. Febs Letters. 489: 46-50. PMID 11231011 DOI: 10.1016/S0014-5793(00)02431-5  0.342
2000 Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2  0.581
2000 Pickering-Brown S, Baker M, Yen SH, Liu WK, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, et al. Pick's disease is associated with mutations in the tau gene. Annals of Neurology. 48: 859-67. PMID 11117542 DOI: 10.1002/1531-8249(200012)48:6<859::Aid-Ana6>3.0.Co;2-1  0.355
2000 Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B, Cottel D, Lendon C, Iwatsubo T, Amouyel P, Chartier-Harlin MC. A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains. Neuroscience Letters. 293: 29-32. PMID 11065130 DOI: 10.1016/S0304-3940(00)01477-4  0.396
2000 Yamazaki M, Arai Y, Baba M, Iwatsubo T, Mori O, Katayama Y, Oyanagi K. Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam. Journal of Neuropathology and Experimental Neurology. 59: 585-91. PMID 10901229 DOI: 10.1093/Jnen/59.7.585  0.307
2000 Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American Journal of Pathology. 157: 331-9. PMID 10880403 DOI: 10.1016/S0002-9440(10)64544-0  0.524
2000 Iwatsubo T. [Alzheimer's disease: basic aspects]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 37: 207-11. PMID 10879068 DOI: 10.3143/Geriatrics.37.207  0.426
2000 Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N. Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology. 54: 1787-95. PMID 10802785 DOI: 10.1212/Wnl.54.9.1787  0.355
2000 Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, et al. A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto) Annals of Neurology. 47: 422-9. PMID 10762152 DOI: 10.1002/1531-8249(200004)47:4<422::Aid-Ana4>3.0.Co;2-G  0.337
2000 Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. The Journal of Biological Chemistry. 275: 17136-42. PMID 10748144 DOI: 10.1074/Jbc.M909624199  0.563
2000 Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. International Journal of Molecular Medicine. 5: 269-73. PMID 10677567 DOI: 10.3892/Ijmm.5.3.269  0.471
2000 Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi H. Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology. Acta Neuropathologica. 99: 331-6. PMID 10663979 DOI: 10.1007/S004010050049  0.348
2000 Lambert J, Mann DM, Goumidi L, Harris JM, Amouyel P, Lendon CL, Iwatsubo T, Chatier-Harlin M. Impact of the APOE promoter polymorphisms on aβ loading in AD brains Neurobiology of Aging. 21: 205. DOI: 10.1016/S0197-4580(00)83249-2  0.331
2000 Leem JY, Saura C, Tomita T, Iwatsubo T, Thinakaran G. Structural domain requirements for presenilin endoproteolysis and Aβ42 overproduction Neurobiology of Aging. 21: 261. DOI: 10.1016/S0197-4580(00)83129-2  0.489
2000 Kamenetz F, Borchelt DR, Tomita T, Iwatsubo T, Sisodia S, Malinow R. Aβ as a homeostatic negative regulator of synaptic function? Neurobiology of Aging. 21: 76-77. DOI: 10.1016/S0197-4580(00)82567-1  0.457
2000 Iwatsubo T, Tomita T, Takikawa R, Watabiki T, Morohashi Y, Takasugi N. Structure-function analysis of presenilins Neurobiology of Aging. 21: 140. DOI: 10.1016/S0197-4580(00)82428-8  0.416
2000 Tomita T, Takasugi N, Takikawa R, Watabiki T, Yauchi M, Iwatsubo T. The integrity of carboxyl terminus of presenilin 2 is essential for its functions Neurobiology of Aging. 21: 110-111. DOI: 10.1016/S0197-4580(00)82295-2  0.414
1999 Tomita T, Iwatsubo T. [Molecular cell biology of presenilins]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 114: 337-46. PMID 10672594 DOI: 10.1254/Fpj.114.337  0.576
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10627-34. PMID 10594046  0.498
1999 Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T. Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42. Neuroreport. 10: 2965-9. PMID 10549806 DOI: 10.1097/00001756-199909290-00017  0.499
1999 Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H. Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans. Neuroscience Letters. 273: 203-7. PMID 10515194 DOI: 10.1016/S0304-3940(99)00644-8  0.535
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... ... Iwatsubo T, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669  0.705
1999 McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/Nbdi.1999.0243  0.403
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6538-48. PMID 10414982  0.351
1999 Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease. Neuroscience Letters. 265: 61-3. PMID 10327206 DOI: 10.1016/S0304-3940(99)00187-1  0.577
1999 Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing Journal of Biological Chemistry. 274: 13818-13823. PMID 10318786 DOI: 10.1074/Jbc.274.20.13818  0.533
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C Terminus of Presenilin Is Required for Overproduction of Amyloidogenic Aβ42 through Stabilization and Endoproteolysis of Presenilin The Journal of Neuroscience. 19: 10627-10634. DOI: 10.1523/Jneurosci.19-24-10627.1999  0.559
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 Upregulation Activates β-Secretase–Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer’s Disease The Journal of Neuroscience. 19: 6538-6548. DOI: 10.1523/Jneurosci.19-15-06538.1999  0.571
1999 Iwatsubo T. Amyloid β Peptides and Presenilins in the Pathogenesis of Alzheimer's Disease Acta Histochemica Et Cytochemica. 32: 13-15. DOI: 10.1267/Ahc.32.13  0.373
1998 Trojanowski JQ, Goedert M, Iwatsubo T, Lee VM. Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death and Differentiation. 5: 832-7. PMID 10203692 DOI: 10.1038/Sj.Cdd.4400432  0.371
1998 Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6  0.506
1998 Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K. The presenilin 2 loop domain interacts with the mu-calpain C-terminal region. International Journal of Molecular Medicine. 1: 797-9. PMID 9852298 DOI: 10.3892/Ijmm.1.5.797  0.527
1998 Hosoda R, Saido TC, Otvos L, Arai T, Mann DM, Lee VM, Trojanowski JQ, Iwatsubo T. Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains. Journal of Neuropathology and Experimental Neurology. 57: 1089-95. PMID 9825946 DOI: 10.1097/00005072-199811000-00012  0.356
1998 Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM, ... Iwatsubo T, et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. The American Journal of Pathology. 153: 1365-70. PMID 9811326 DOI: 10.1016/S0002-9440(10)65722-7  0.354
1998 Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Annals of Neurology. 44: 415-22. PMID 9749615 DOI: 10.1002/Ana.410440324  0.473
1998 Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. The Journal of Biological Chemistry. 273: 21153-60. PMID 9694871 DOI: 10.1074/Jbc.273.33.21153  0.719
1998 Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, et al. Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Annals of Neurology. 44: 17-26. PMID 9667589 DOI: 10.1002/ana.410440108  0.37
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X  0.634
1998 Tomita T, Chang TY, Kodama T, Iwatsubo T. βAPP γ-secretase and SREBP site 2 protease are two different enzymes Neuroreport. 9: 911-913. PMID 9579689 DOI: 10.1097/00001756-199803300-00027  0.528
1998 Iwatsubo T. Aβ42, Presenilins, and Alzheimer’s Disease Neurobiology of Aging. 19. PMID 9562460 DOI: 10.1016/S0197-4580(98)00027-X  0.42
1998 Iwatsubo T. Amyloid β Protein in Plasma as a Diagnostic Marker for Alzheimer’s Disease Neurobiology of Aging. 19: 161-163. PMID 9558155 DOI: 10.1016/S0197-4580(98)00015-3  0.395
1998 Davies P, Resnick J, Resnick B, Gilman S, Growdon JH, Khachaturian ZS, Radebaugh TS, Roses AD, Selkoe DJ, Trojanowski JQ, Blass JP, Gibson GE, Sheu KFR, Blennow K, Delacourte A, ... ... Iwatsubo T, et al. Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' Neurobiology of Aging. 19: 109-116. PMID 9558143 DOI: 10.1016/S0197-4580(98)00022-0  0.631
1998 Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells. Biochemical and Biophysical Research Communications. 244: 751-5. PMID 9535737 DOI: 10.1006/bbrc.1998.8336  0.485
1998 Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. Acta Neuropathologica. 95: 117-22. PMID 9498044 DOI: 10.1007/S004010050774  0.433
1998 Iwatsubo T, Baba M, Nakaio S, Tu P-, Tomita T, Nakaya K, -Y. Lee VM, Trojanowski JQ. α-SYNUCLEIN IS A COMPONENT OF LEWY BODIES Journal of Neuropathology and Experimental Neurology. 57: 509. DOI: 10.1097/00005072-199805000-00179  0.406
1998 Schmidt ML, -Y. Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Troianowski JO. AMYLOID PLAQUES IN GUAM AMYOTROPHIC LATERAL SCLEROSIS/AND PARKINSONISM-DEMENTIA COMPLEX (ALS/PDC) CONTAIN SPECIES OF Aβ SIMILAR TO THOSE FOUND IN THE AMYLOID PLAQUES OF ALZHEIMERʼS DISEASE (AD) AND PATHOLOGICAL AGING (PA) Journal of Neuropathology and Experimental Neurology. 57: 475. DOI: 10.1097/00005072-199805000-00037  0.405
1997 Galvin JE, Lee VM, Baba M, Mann DM, Dickson DW, Yamaguchi H, Schmidt ML, Iwatsubo T, Trojanowski JQ. Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit. Annals of Neurology. 42: 595-603. PMID 9382471 DOI: 10.1002/Ana.410420410  0.36
1997 Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport. 8: 2797-801. PMID 9295120 DOI: 10.1097/00001756-199708180-00029  0.48
1997 Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM, Doms RW. Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nature Medicine. 3: 1021-3. PMID 9288730 DOI: 10.1038/Nm0997-1021  0.357
1997 Nishimoto I, Okamoto T, Giambarella U, Iwatsubo T. Apoptosis in neurodegenerative diseases. Advances in Pharmacology. 41: 337-368. PMID 9204151 DOI: 10.1016/S1054-3589(08)61064-9  0.316
1997 Takamatsu J, Kimura T, Kondo A, Iwatsubo T. Subpial amyloid plaques in the cerebellum in a case of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 8: 157-62. PMID 9137893 DOI: 10.1159/000106625  0.429
1997 Mann DM, Pickering-Brown SM, Bayatti NN, Wright AE, Owen F, Iwatsubo T, Saido TC. An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease. Neuroscience Letters. 222: 57-60. PMID 9121723 DOI: 10.1016/S0304-3940(97)13342-0  0.363
1997 Mann DM, Iwatsubo T, Pickering-Brown SM, Owen F, Saido TC, Perry RH. Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neuroscience Letters. 221: 81-4. PMID 9121705 DOI: 10.1016/S0304-3940(96)13294-8  0.387
1997 Kosaka T, Imagawa M, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A, Fukushima T, Imai K, Iwatsubo T. The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta 42(43) Neurology. 48: 741-745. PMID 9065558 DOI: 10.1212/Wnl.48.3.741  0.342
1997 Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898 DOI: 10.1073/Pnas.94.5.2025  0.549
1997 Mann DM, Iwatsubo T, Nochlin D, Sumi SM, Levy-Lahad E, Bird TD. Amyloid (Abeta) deposition in chromosome 1-linked Alzheimer's disease: the Volga German families. Annals of Neurology. 41: 52-7. PMID 9005865 DOI: 10.1002/Ana.410410110  0.429
1996 Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S. Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain. Neuroscience Letters. 215: 173-6. PMID 8899741 DOI: 10.1016/0304-3940(96)12970-0  0.403
1996 Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K. Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43). Biochemical and Biophysical Research Communications. 227: 730-5. PMID 8886002 DOI: 10.1006/bbrc.1996.1577  0.537
1996 Kanemaru K, Iwatsubo T, Ihara Y. Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain. Neuroscience Letters. 214: 196-8. PMID 8878117 DOI: 10.1016/0304-3940(96)12893-7  0.504
1996 Mann DM, Iwatsubo T. Diffuse plaques in the cerebellum and corpus striatum in Down's syndrome contain amyloid beta protein (A beta) only in the form of A beta 42(43). Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 115-20. PMID 8819131 DOI: 10.1006/Neur.1996.0017  0.325
1996 Nakano I, Iwatsubo T, Otsuka N, Kamei M, Matsumura K, Mannen T. Some unusual responses of astrocytes to ghost tangles in a long duration case of juvenile Alzheimer's disease: an electron microscopic study. Journal of the Neurological Sciences. 136: 41-6. PMID 8815177 DOI: 10.1016/0022-510X(95)00256-2  0.324
1996 Mann DM, Iwatsubo T, Snowden JS. Atypical amyloid (A beta) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific A beta monoclonal antibodies. Acta Neuropathologica. 91: 647-53. PMID 8781665 DOI: 10.1007/S004010050479  0.415
1996 Mann DM, Iwatsubo T, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD, Poorkaj P, Hardy J, Hutton M, Prihar G, Crook R, Rossor MN, Haltia M. Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Annals of Neurology. 40: 149-56. PMID 8773595 DOI: 10.1002/Ana.410400205  0.436
1996 Fukumoto H, Asami-Odaka A, Suzuki N, Iwatsubo T. Association of Aβ40-positive Senile Plaques with Microglial Cells in the Brains of Patients with Alzheimer's Disease and in Non-demented Aged Individuals Neurodegeneration. 5: 13-17. PMID 8731377 DOI: 10.1006/Neur.1996.0002  0.399
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Lewy bodies: purification from diffuse Lewy body disease brains. Annals of the New York Academy of Sciences. 786: 195-205. PMID 8687019 DOI: 10.1111/J.1749-6632.1996.Tb39062.X  0.449
1996 Yamatsuji T, Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H, Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, Kinane TB, Giambarella U, Nishimoto I. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science (New York, N.Y.). 272: 1349-52. PMID 8650548 DOI: 10.1126/Science.272.5266.1349  0.38
1996 Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman ML, Rossor MN. Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. The American Journal of Pathology. 148: 1257-66. PMID 8644866  0.485
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. The American Journal of Pathology. 148: 1517-29. PMID 8623921  0.431
1996 Kume H, Maruyama K, Tomita T, Iwatsubo T, Saido TC, Obata K. Molecular cloning of a novel basic helix-loop-helix protein from the rat brain. Biochemical and Biophysical Research Communications. 219: 526-30. PMID 8605021 DOI: 10.1006/bbrc.1996.0267  0.467
1996 Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T. Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. The American Journal of Pathology. 148: 259-65. PMID 8546214  0.46
1996 Saido T, Iwatsubo T, Yokota M, Kawashima S. 795 Post-secretory catabolism of ß-amyloid in brain Neurobiology of Aging. 17: S197-S198. DOI: 10.1016/S0197-4580(96)80797-4  0.346
1996 Hosoda R, Saido T, Otvos L, Arai T, Iwatsubo T. 703 Detection of isoaspartyl form of amyloid β protein in Aizheimer's disease brains Neurobiology of Aging. 17: S175. DOI: 10.1016/S0197-4580(96)80705-6  0.355
1996 Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. 507 Distribution of Phosphorylated Tau in Neonatal and Adult Rat Brains Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80509-4  0.449
1996 Maruyama K, Tomita T, Ishiura S, Kume H, Kuzume H, Asada H, Kawamura Y, Kanbara N, Saido TC, Iwatsubo T, Obata K. 399 The familial Alzheimer disease-linked mutations of Val717 of amyloid precursor protein is specific for the increased secretion of the longer Aβ Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80401-5  0.556
1996 Kosaka T, Imagawa M, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A, Fukushima T, Imai K, Iwatsubo T. 326 The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid β protein ending at Aβ42(43) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80328-9  0.364
1996 Tomita T, Maruyama K, Saido T, Hosoda R, Tokuhiro S, Kume H, Kuzume H, Asada H, Kawamura Y, Iwatsubo T, Obata K. 59 Characterization of presenilins overexpressed in culture cells Neurobiology of Aging. 17: S15. DOI: 10.1016/S0197-4580(96)80061-3  0.418
1995 Mann DM, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathologica. 90: 472-7. PMID 8560980 DOI: 10.1007/Bf00294808  0.507
1995 Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron. 14: 457-66. PMID 7857653 DOI: 10.1016/0896-6273(95)90301-1  0.512
1995 Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Annals of Neurology. 37: 294-9. PMID 7695229 DOI: 10.1002/Ana.410370305  0.499
1995 Mann DM, Pickering-Brown SM, Siddons MA, Iwatsubo T, Ihara Y, Asami-Odaka A, Suzuki N. The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype. Neuroscience Letters. 196: 105-8. PMID 7501233 DOI: 10.1016/0304-3940(95)11860-Y  0.512
1995 Mann DMA, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid ? protein (A?) deposition: association with A?40-containing plaques Acta Neuropathologica. 90: 472-477. DOI: 10.1007/S004010050358  0.538
1994 Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y. High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. The American Journal of Pathology. 145: 452-60. PMID 8053502  0.432
1994 Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13: 45-53. PMID 8043280 DOI: 10.1016/0896-6273(94)90458-8  0.509
1994 Iwatsubo T, Hasegawa M, Ihara Y. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathologica. 88: 129-36. PMID 7985493 DOI: 10.1007/Bf00294505  0.539
1994 Arai H, Higuchi S, Muramatsu T, Iwatsubo T, Sasaki H, Trojanowski JQ. Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease The Lancet. 344: 1307-1307. PMID 7818703 DOI: 10.1016/S0140-6736(94)90799-4  0.304
1993 Endoh R, Ogawara M, Iwatsubo T, Nakano I, Mori H. Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease. Brain Research. 601: 164-72. PMID 8431763 DOI: 10.1016/0006-8993(93)91707-Y  0.399
1992 Nakano I, Iwatsubo T, Otsuka N, Kamei M, Matsumura K, Mannen T. Paired helical filaments in astrocytes: electron microscopy and immunohistochemistry in a case of atypical Alzheimer's disease. Acta Neuropathologica. 83: 228-32. PMID 1557954 DOI: 10.1007/BF00296783  0.334
1992 Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y. Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. The American Journal of Pathology. 140: 277-82. PMID 1310831  0.446
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