Rodrigo A. Cunha, PhD - Publications

Affiliations: 
Center for Neuroscience and Cell Biology University of Coimbra, Coimbra, Coimbra, Portugal 
Area:
Neuromodulation
Website:
http://www.cnbc.pt/research/areaA4_2.asp?lg=2

179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, ... ... Cunha RA, et al. Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. Eneuro. 5. PMID 30627646 DOI: 10.1523/ENEURO.0385-18.2018  0.44
2018 Leffa DT, Pandolfo P, Gonçalves N, Machado NJ, de Souza CM, Real JI, Silva AC, Silva HB, Köfalvi A, Cunha RA, Ferreira SG. Adenosine A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making. Frontiers in Molecular Neuroscience. 11: 475. PMID 30618621 DOI: 10.3389/fnmol.2018.00475  0.32
2018 Rodrigues RJ, Marques JM, Cunha RA. Purinergic signalling and brain development. Seminars in Cell & Developmental Biology. PMID 30529149 DOI: 10.1016/j.semcdb.2018.12.001  0.32
2018 Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F. Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation. Human Molecular Genetics. PMID 30010864 DOI: 10.1093/hmg/ddy264  0.32
2018 Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, ... ... Cunha RA, et al. Age-related shift in LTD is dependent on neuronal adenosine A receptors interplay with mGluR5 and NMDA receptors. Molecular Psychiatry. PMID 29950682 DOI: 10.1038/s41380-018-0110-9  0.48
2018 Simões AP, Silva CG, Marques JM, Pochmann D, Porciúncula LO, Ferreira S, Oses JP, Beleza RO, Real JI, Köfalvi A, Bahr BA, Lerma J, Cunha RA, Rodrigues RJ. Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation. Cell Death & Disease. 9: 297. PMID 29463792 DOI: 10.1038/s41419-018-0351-1  0.32
2017 Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F. The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. Scientific Reports. 7: 9452. PMID 28842709 DOI: 10.1038/s41598-017-10147-x  0.32
2016 Fonseca R, Carvalho RA, Lemos C, Sequeira AC, Pita IR, Carvalho F, Silva CD, Prediger RD, Jarak I, Cunha RA, Fontes Ribeiro CA, Köfalvi A, Pereira FC. Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice. Cns Neuroscience & Therapeutics. PMID 27762079 DOI: 10.1111/cns.12649  0.32
2016 Pinheiro BS, Lemos C, Neutzling-Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, Köfalvi A. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Research Bulletin. PMID 27208730 DOI: 10.1016/j.brainresbull.2016.05.009  0.32
2016 Köfalvi A, Lemos C, Martín-Moreno AM, Pinheiro BS, García-García L, Pozo MA, Valério-Fernandes Â, Beleza RO, Agostinho P, Rodrigues RJ, Pasquaré SJ, Cunha RA, de Ceballos ML. Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. Neuropharmacology. PMID 26976670 DOI: 10.1016/j.neuropharm.2016.03.015  0.32
2016 Machado NJ, Simões AP, Silva HB, Ardais AP, Kaster MP, Garção P, Rodrigues DI, Pochmann D, Santos AI, Araújo IM, Porciúncula LO, Tomé ÂR, Köfalvi A, Vaugeois JM, Agostinho P, ... ... Cunha RA, et al. Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. Molecular Neurobiology. PMID 26860412 DOI: 10.1007/s12035-016-9774-9  1
2016 Rodrigues RJ, Almeida T, Díaz-Hernández M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F, Cunha RA. Presynaptic P2X1-3 and α3-containing Nicotinic Receptors Assemble Into Functionally Interacting Ion Channels in the Rat Hippocampus. Neuropharmacology. PMID 26801076 DOI: 10.1016/j.neuropharm.2016.01.022  1
2016 Lemos C, Rial D, Gonçalves FQ, Pires J, Silva HB, Matheus FC, da Silva AC, Marques JM, Rodrigues RJ, Jarak I, Prediger RD, Reis F, Carvalho RA, Pereira FC, Cunha RA. High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus Neuroscience. 315: 196-205. DOI: 10.1016/j.neuroscience.2015.12.018  1
2016 Canas PM, Cunha RA. Subsynaptic membrane fractionation Neuromethods. 110: 31-37. DOI: 10.1007/978-1-4939-3064-73  1
2015 Rial D, Lemos C, Pinheiro H, Duarte JM, Gonçalves FQ, Real JI, Prediger RD, Gonçalves N, Gomes CA, Canas PM, Agostinho P, Cunha RA. Depression as a Glial-Based Synaptic Dysfunction. Frontiers in Cellular Neuroscience. 9: 521. PMID 26834566 DOI: 10.3389/fncel.2015.00521  1
2015 Duarte JM, Cunha RA, Carvalho RA. Adenosine A1 receptors control the metabolic recovery after hypoxia in rat hippocampal slices. Journal of Neurochemistry. PMID 26709861 DOI: 10.1111/jnc.13512  1
2015 Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV. Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity. Cerebral Cortex (New York, N.Y. : 1991). PMID 26534909 DOI: 10.1093/cercor/bhv268  0.48
2015 Pliássova A, Lopes JP, Lemos C, Oliveira CR, Cunha RA, Agostinho P. The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease. Molecular Neurobiology. PMID 26497029 DOI: 10.1007/s12035-015-9491-9  1
2015 Lemos C, Pinheiro BS, Beleza RO, Marques JM, Rodrigues RJ, Cunha RA, Rial D, Köfalvi A. Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signalling. PMID 26446689 DOI: 10.1007/s11302-015-9474-3  1
2015 Bitencourt RM, Alpár A, Cinquina V, Ferreira SG, Pinheiro BS, Lemos C, Ledent C, Takahashi RN, Sialana FJ, Lubec G, Cunha RA, Harkany T, Köfalvi A. Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents. Neurochemistry International. PMID 26196379 DOI: 10.1016/j.neuint.2015.07.014  0.44
2015 Valente-Silva P, Lemos C, Köfalvi A, Cunha RA, Jones JG. Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices. Nmr in Biomedicine. PMID 26174755 DOI: 10.1002/nbm.3355  1
2015 Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues AL, Porciúncula LO, Chen JF, Tomé ÂR, Agostinho P, Canas PM, Cunha RA. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proceedings of the National Academy of Sciences of the United States of America. 112: 7833-8. PMID 26056314 DOI: 10.1073/pnas.1423088112  0.44
2015 Madeira MH, Elvas F, Boia R, Gonçalves FQ, Cunha RA, Ambrósio AF, Santiago AR. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure. Journal of Neuroinflammation. 12: 115. PMID 26054642 DOI: 10.1186/s12974-015-0333-5  1
2015 Rodrigues RJ, Tomé AR, Cunha RA. ATP as a multi-target danger signal in the brain. Frontiers in Neuroscience. 9: 148. PMID 25972780 DOI: 10.3389/fnins.2015.00148  1
2015 Li W, Silva HB, Real J, Wang YM, Rial D, Li P, Payen MP, Zhou Y, Muller CE, Tomé AR, Cunha RA, Chen JF. Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models. Neurobiology of Disease. 79: 70-80. PMID 25892655 DOI: 10.1016/j.nbd.2015.03.030  1
2015 Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF. Deletion of Adenosine A2A Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia. Biological Psychiatry. PMID 25869810 DOI: 10.1016/j.biopsych.2015.02.026  1
2015 Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F. The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. Journal of Neurochemistry. 134: 135-46. PMID 25824528 DOI: 10.1111/jnc.13109  1
2015 Li P, Rial D, Canas PM, Yoo JH, Li W, Zhou X, Wang Y, van Westen GJ, Payen MP, Augusto E, Gonçalves N, Tomé AR, Li Z, Wu Z, Hou X, ... ... Cunha RA, et al. Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Molecular Psychiatry. PMID 25802981 DOI: 10.1038/mp.2015.43  0.44
2015 Gonçalves FQ, Pires J, Pliassova A, Beleza R, Lemos C, Marques JM, Rodrigues RJ, Canas PM, Köfalvi A, Cunha RA, Rial D. Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus. The European Journal of Neuroscience. 41: 878-88. PMID 25704806 DOI: 10.1111/ejn.12851  0.32
2015 Li P, Rial D, Canas PM, Yoo JH, Li W, Zhou X, Wang Y, van Westen GJ, Payen MP, Augusto E, Gonçalves N, Tomé AR, Li Z, Wu Z, Hou X, ... ... Cunha RA, et al. Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Molecular Psychiatry. PMID 25687775 DOI: 10.1038/mp.2014.182  0.44
2015 Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-García JM, Alberch J, Cunha RA, Gruart A, Pérez-Navarro E. Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease. Neurobiology of Disease. 74: 41-57. PMID 25449908 DOI: 10.1016/j.nbd.2014.11.004  1
2015 Ferreira SG, Gonçalves FQ, Marques JM, Tomé ÂR, Rodrigues RJ, Nunes-Correia I, Ledent C, Harkany T, Venance L, Cunha RA, Köfalvi A. Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. British Journal of Pharmacology. 172: 1074-86. PMID 25296982 DOI: 10.1111/bph.12970  1
2015 Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues ALS, Porciúncula LO, Chen JF, Tomé ÂR, Agostinho P, Canas PM, Cunha RA. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress Proceedings of the National Academy of Sciences of the United States of America. 112: 7833-7838. DOI: 10.1073/pnas.1423088112  1
2015 Gomes C, George J, Chen JF, Cunha RA. Role of adenosine A2A receptors in the control of neuroinflammation-relevance for parkinson's disease The Adenosinergic System: a Non-Dopaminergic Target in Parkinson's Disease. 81-99. DOI: 10.1007/978-3-319-20273-0_5  1
2015 Prediger RD, Matheus FC, De Oliveira PA, Rial D, Moretti M, De Souza ACG, Aguiar AS, Cunha RA. Adenosine A2A receptor-mediated control of non-motor functions in parkinson's disease The Adenosinergic System: a Non-Dopaminergic Target in Parkinson's Disease. 183-205. DOI: 10.1007/978-3-319-20273-0_10  1
2014 Rial D, Castro AA, Machado N, Garção P, Gonçalves FQ, Silva HB, Tomé AR, Köfalvi A, Corti O, Raisman-Vozari R, Cunha RA, Prediger RD. Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease. Plos One. 9: e114216. PMID 25486126 DOI: 10.1371/journal.pone.0114216  1
2014 Zappettini S, Grilli M, Olivero G, Chen J, Padolecchia C, Pittaluga A, Tomé AR, Cunha RA, Marchi M. Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens. Frontiers in Cellular Neuroscience. 8: 332. PMID 25360085 DOI: 10.3389/fncel.2014.00332  1
2014 Rial D, Lara DR, Cunha RA. The adenosine neuromodulation system in schizophrenia. International Review of Neurobiology. 119: 395-449. PMID 25175974 DOI: 10.1016/B978-0-12-801022-8.00016-7  1
2014 Santiago AR, Baptista FI, Santos PF, Cristóvão G, Ambrósio AF, Cunha RA, Gomes CA. Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases. Mediators of Inflammation. 2014: 465694. PMID 25132733 DOI: 10.1155/2014/465694  1
2014 Coelho JE, Alves P, Canas PM, Valadas JS, Shmidt T, Batalha VL, Ferreira DG, Ribeiro JA, Bader M, Cunha RA, do Couto FS, Lopes LV. Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety. Frontiers in Psychiatry. 5: 67. PMID 24982640 DOI: 10.3389/fpsyt.2014.00067  1
2014 Rial D, Pandolfo P, Bitencourt RM, Pamplona FA, Moreira KM, Hipolide D, Dombrowski PA, Da Cunha C, Walz R, Cunha RA, Takahashi RN, Prediger RD. Cellular prion protein (PrP(C)) modulates ethanol-induced behavioral adaptive changes in mice. Behavioural Brain Research. 271: 325-32. PMID 24975422 DOI: 10.1016/j.bbr.2014.05.067  1
2014 Cristovão G, Pinto MJ, Cunha RA, Almeida RD, Gomes CA. Activation of microglia bolsters synapse formation. Frontiers in Cellular Neuroscience. 8: 153. PMID 24917790 DOI: 10.3389/fncel.2014.00153  1
2014 Rial D, Pamplona FA, Moreira EL, Moreira KM, Hipolide D, Rodrigues DI, Dombrowski PA, Da Cunha C, Agostinho P, Takahashi RN, Walz R, Cunha RA, Prediger RD. Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system. The European Journal of Neuroscience. 40: 2479-86. PMID 24766164 DOI: 10.1111/ejn.12600  1
2014 Ardais AP, Borges MF, Rocha AS, Sallaberry C, Cunha RA, Porciúncula LO. Caffeine triggers behavioral and neurochemical alterations in adolescent rats. Neuroscience. 270: 27-39. PMID 24726984 DOI: 10.1016/j.neuroscience.2014.04.003  1
2014 Ribeiro PO, Tomé AR, Silva HB, Cunha RA, Antunes LM. Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices. Brain Research. 1560: 10-7. PMID 24637258 DOI: 10.1016/j.brainres.2014.03.004  1
2014 Garção P, Oliveira CR, Cunha RA, Agostinho P. Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neuroscience Letters. 566: 106-10. PMID 24607281 DOI: 10.1016/j.neulet.2014.02.018  1
2014 Rodrigues DI, Gutierres J, Pliássova A, Oliveira CR, Cunha RA, Agostinho P. Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus. Journal of Alzheimer's Disease : Jad. 40: 981-92. PMID 24531160 DOI: 10.3233/JAD-132030  1
2014 Carmo MR, Menezes AP, Nunes AC, Pliássova A, Rolo AP, Palmeira CM, Cunha RA, Canas PM, Andrade GM. The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis. Neuropharmacology. 81: 142-52. PMID 24508709 DOI: 10.1016/j.neuropharm.2014.01.045  1
2014 Salamone A, Zappettini S, Grilli M, Olivero G, Agostinho P, Tomé AR, Chen J, Pittaluga A, Cunha RA, Marchi M. Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens. Neuropharmacology. 79: 488-97. PMID 24373903 DOI: 10.1016/j.neuropharm.2013.12.014  1
2014 Carmo MR, Simões AP, Fonteles AA, Souza CM, Cunha RA, Andrade GM. ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice. The European Journal of Neuroscience. 39: 614-22. PMID 24304101 DOI: 10.1111/ejn.12435  1
2014 Silva CD, Neves AF, Dias AI, Freitas HJ, Mendes SM, Pita I, Viana SD, de Oliveira PA, Cunha RA, Fontes Ribeiro CA, Prediger RD, Pereira FC. A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice. Neurotoxicity Research. 25: 295-304. PMID 24072398 DOI: 10.1007/s12640-013-9423-2  1
2014 Canas PM, Simões AP, Rodrigues RJ, Cunha RA. Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease. Neuropharmacology. 76: 51-6. PMID 24029236 DOI: 10.1016/j.neuropharm.2013.08.026  1
2014 Wei CJ, Augusto E, Gomes CA, Singer P, Wang Y, Boison D, Cunha RA, Yee BK, Chen JF. Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain. Biological Psychiatry. 75: 855-63. PMID 23820821 DOI: 10.1016/j.biopsych.2013.05.003  1
2014 Bitencourt RM, Alpár A, Cinquina V, Ferreira SG, Pinheiro BS, Lemos C, Ledent C, Takahashi RN, Sialana FJ, Lubec G, Cunha RA, Harkany T, Köfalvi A. Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents Neurochemistry International. DOI: 10.1016/j.neuint.2015.07.014  1
2013 Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF. Adenosine Aâ‚‚A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. Plos One. 8: e80902. PMID 24312250 DOI: 10.1371/journal.pone.0080902  1
2013 Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18492-502. PMID 24259572 DOI: 10.1523/JNEUROSCI.1828-13.2013  0.44
2013 Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, ... ... Cunha RA, et al. Adenosine receptor antagonists including caffeine alter fetal brain development in mice. Science Translational Medicine. 5: 197ra104. PMID 23926202 DOI: 10.1126/scitranslmed.3006258  1
2013 Soares E, Prediger RD, Nunes S, Castro AA, Viana SD, Lemos C, De Souza CM, Agostinho P, Cunha RA, Carvalho E, Fontes Ribeiro CA, Reis F, Pereira FC. Spatial memory impairments in a prediabetic rat model. Neuroscience. 250: 565-77. PMID 23912035 DOI: 10.1016/j.neuroscience.2013.07.055  1
2013 Augusto E, Matos M, Sévigny J, El-Tayeb A, Bynoe MS, Müller CE, Cunha RA, Chen JF. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11390-9. PMID 23843511 DOI: 10.1523/JNEUROSCI.5817-12.2013  1
2013 Garção P, Szabó EC, Wopereis S, Castro AA, Tomé ÂR, Prediger RD, Cunha RA, Agostinho P, Köfalvi A. Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. British Journal of Pharmacology. 169: 1600-11. PMID 23638679 DOI: 10.1111/bph.12234  1
2013 Gonçalves N, Simões AT, Cunha RA, de Almeida LP. Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. Annals of Neurology. 73: 655-66. PMID 23625556 DOI: 10.1002/ana.23866  1
2013 Aguiar AS, Moreira EL, Hoeller AA, Oliveira PA, Córdova FM, Glaser V, Walz R, Cunha RA, Leal RB, Latini A, Prediger RD. Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 243: 46-53. PMID 23558088 DOI: 10.1016/j.neuroscience.2013.03.039  1
2013 Gomes C, Ferreira R, George J, Sanches R, Rodrigues DI, Gonçalves N, Cunha RA. Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia. Journal of Neuroinflammation. 10: 16. PMID 23363775 DOI: 10.1186/1742-2094-10-16  1
2013 Espinosa J, Rocha A, Nunes F, Costa MS, Schein V, Kazlauckas V, Kalinine E, Souza DO, Cunha RA, Porciúncula LO. Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia. Journal of Alzheimer's Disease : Jad. 34: 509-18. PMID 23241554 DOI: 10.3233/JAD-111982  1
2012 Simões AP, Duarte JA, Agasse F, Canas PM, Tomé AR, Agostinho P, Cunha RA. Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway. Journal of Neuroinflammation. 9: 204. PMID 22901528 DOI: 10.1186/1742-2094-9-204  1
2012 Matos M, Augusto E, Machado NJ, dos Santos-Rodrigues A, Cunha RA, Agostinho P. Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake. Journal of Alzheimer's Disease : Jad. 31: 555-67. PMID 22647260 DOI: 10.3233/JAD-2012-120469  1
2012 Duarte JM, Agostinho PM, Carvalho RA, Cunha RA. Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice. Plos One. 7: e21899. PMID 22514596 DOI: 10.1371/journal.pone.0021899  1
2012 Matos M, Augusto E, Santos-Rodrigues AD, Schwarzschild MA, Chen JF, Cunha RA, Agostinho P. Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia. 60: 702-16. PMID 22298379 DOI: 10.1002/glia.22290  1
2012 Duarte JM, Ferreira SG, Carvalho RA, Cunha RA, Köfalvi A. CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus. Neurochemistry International. 60: 1-8. PMID 22085448 DOI: 10.1016/j.neuint.2011.10.019  1
2011 Costenla AR, Diógenes MJ, Canas PM, Rodrigues RJ, Nogueira C, Maroco J, Agostinho PM, Ribeiro JA, Cunha RA, de Mendonça A. Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing. The European Journal of Neuroscience. 34: 12-21. PMID 21615561 DOI: 10.1111/j.1460-9568.2011.07719.x  1
2011 Musante V, Summa M, Cunha RA, Raiteri M, Pittaluga A. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of Neurochemistry. 117: 516-27. PMID 21348870 DOI: 10.1111/j.1471-4159.2011.07223.x  1
2011 Pandolfo P, Silveirinha V, dos Santos-Rodrigues A, Venance L, Ledent C, Takahashi RN, Cunha RA, Köfalvi A. Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum. European Journal of Pharmacology. 655: 38-45. PMID 21266173 DOI: 10.1016/j.ejphar.2011.01.013  1
2011 Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA. Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction. Journal of Neurochemistry. 117: 100-11. PMID 21235574 DOI: 10.1111/j.1471-4159.2011.07178.x  1
2011 Gomes CV, Kaster MP, Tomé AR, Agostinho PM, Cunha RA. Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochimica Et Biophysica Acta. 1808: 1380-99. PMID 21145878 DOI: 10.1016/j.bbamem.2010.12.001  1
2011 Martire A, Tebano MT, Chiodi V, Ferreira SG, Cunha RA, Köfalvi A, Popoli P. Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission. Journal of Neurochemistry. 116: 273-80. PMID 21062287 DOI: 10.1111/j.1471-4159.2010.07101.x  1
2010 Agostinho P, Cunha RA, Oliveira C. Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Current Pharmaceutical Design. 16: 2766-78. PMID 20698820  1
2010 Gaspar JM, Baptista FI, Galvão J, Castilho AF, Cunha RA, Ambrósio AF. Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals. Neuroscience. 169: 1589-600. PMID 20600668 DOI: 10.1016/j.neuroscience.2010.06.021  1
2010 de Mendonça A, Cunha RA. Putative neuroprotective effects of caffeine in clinical trials. Concluding remarks. Journal of Alzheimer's Disease : Jad. 20: S249-52. PMID 20448306 DOI: 10.3233/JAD-2010-01411  1
2010 de Mendonça A, Cunha RA. Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders. Journal of Alzheimer's Disease : Jad. 20: S1-2. PMID 20448305 DOI: 10.3233/JAD-2010-01420  1
2010 Cunha RA, Agostinho PM. Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline. Journal of Alzheimer's Disease : Jad. 20: S95-116. PMID 20182043 DOI: 10.3233/JAD-2010-1408  1
2010 Costenla AR, Cunha RA, de Mendonça A. Caffeine, adenosine receptors, and synaptic plasticity. Journal of Alzheimer's Disease : Jad. 20: S25-34. PMID 20182030 DOI: 10.3233/JAD-2010-091384  1
2010 Cognato GP, Agostinho PM, Hockemeyer J, Müller CE, Souza DO, Cunha RA. Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life. Journal of Neurochemistry. 112: 453-62. PMID 19878534 DOI: 10.1111/j.1471-4159.2009.06465.x  1
2009 Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14741-51. PMID 19940169 DOI: 10.1523/JNEUROSCI.3728-09.2009  1
2009 Quiroz C, Luján R, Uchigashima M, Simoes AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S. Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. Thescientificworldjournal. 9: 1321-44. PMID 19936569 DOI: 10.1100/tsw.2009.143  1
2009 Duarte JM, Carvalho RA, Cunha RA, Gruetter R. Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. Journal of Neurochemistry. 111: 368-79. PMID 19694901 DOI: 10.1111/j.1471-4159.2009.06349.x  1
2009 Velloso NA, Dalmolin GD, Gomes GM, Rubin MA, Canas PM, Cunha RA, Mello CF. Spermine improves recognition memory deficit in a rodent model of Huntington's disease. Neurobiology of Learning and Memory. 92: 574-80. PMID 19632348 DOI: 10.1016/j.nlm.2009.07.006  1
2009 Gomes CA, Simões PF, Canas PM, Quiroz C, Sebastião AM, Ferré S, Cunha RA, Ribeiro JA. GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors. Journal of Neurochemistry. 108: 1208-19. PMID 19141075 DOI: 10.1111/j.1471-4159.2009.05876.x  1
2009 Ferreira SG, Lomaglio T, Avelino A, Cruz F, Oliveira CR, Cunha RA, Köfalvi A. N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. Neuropharmacology. 56: 676-83. PMID 19101577 DOI: 10.1016/j.neuropharm.2008.12.001  1
2009 Canas PM, Duarte JM, Rodrigues RJ, Köfalvi A, Cunha RA. Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiology of Aging. 30: 1877-84. PMID 18304697 DOI: 10.1016/j.neurobiolaging.2008.01.003  1
2008 Cunha RA. [Caffeine, adenosine receptors, memory and Alzheimer disease]. Medicina ClíNica. 131: 790-5. PMID 19094882 DOI: 10.1016/S0025-7753(08)75506-4  1
2008 Cunha RA, Ferré S, Vaugeois JM, Chen JF. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Current Pharmaceutical Design. 14: 1512-24. PMID 18537674 DOI: 10.2174/138161208784480090  1
2008 Ferré S, Quiroz C, Woods AS, Cunha R, Popoli P, Ciruela F, Lluis C, Franco R, Azdad K, Schiffmann SN. An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. Current Pharmaceutical Design. 14: 1468-74. PMID 18537670 DOI: 10.2174/138161208784480108  1
2008 Donato R, Rodrigues RJ, Takahashi M, Tsai MC, Soto D, Miyagi K, Villafuertes RG, Cunha RA, Edwards FA. GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx. Cell Calcium. 44: 521-32. PMID 18468677 DOI: 10.1016/j.ceca.2008.03.006  1
2008 Silva AM, Rodrigues RJ, Tomé AR, Cunha RA, Misler S, Rosário LM, Santos RM. Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells. Pancreas. 36: 279-83. PMID 18362842 DOI: 10.1097/MPA.0b013e31815a8473  1
2008 Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2970-5. PMID 18354001 DOI: 10.1523/JNEUROSCI.5255-07.2008  1
2008 Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF. Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Annals of Neurology. 63: 338-46. PMID 18300283 DOI: 10.1002/ana.21313  1
2008 Cunha GM, Canas PM, Melo CS, Hockemeyer J, Müller CE, Oliveira CR, Cunha RA. Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Experimental Neurology. 210: 776-81. PMID 18191838 DOI: 10.1016/j.expneurol.2007.11.013  1
2008 Rebola N, Lujan R, Cunha RA, Mulle C. Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron. 57: 121-34. PMID 18184569 DOI: 10.1016/j.neuron.2007.11.023  1
2008 Cunha RA. Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity. Neurochemistry International. 52: 65-72. PMID 17664029 DOI: 10.1016/j.neuint.2007.06.026  1
2008 Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA. Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats. Neurobiology of Aging. 29: 1597-601. PMID 17481781 DOI: 10.1016/j.neurobiolaging.2007.03.025  1
2007 Ferré S, Ciruela F, Quiroz C, Luján R, Popoli P, Cunha RA, Agnati LF, Fuxe K, Woods AS, Lluis C, Franco R. Adenosine receptor heteromers and their integrative role in striatal function. Thescientificworldjournal. 7: 74-85. PMID 17982579 DOI: 10.1100/tsw.2007.211  1
2007 Duarte JM, Oses JP, Rodrigues RJ, Cunha RA. Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats. Neuroscience. 149: 382-91. PMID 17869435 DOI: 10.1016/j.neuroscience.2007.08.005  1
2007 Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferré S. Adenosine A2A receptors and basal ganglia physiology. Progress in Neurobiology. 83: 277-92. PMID 17646043 DOI: 10.1016/j.pneurobio.2007.05.001  1
2007 Silva CG, Porciúncula LO, Canas PM, Oliveira CR, Cunha RA. Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiology of Disease. 27: 182-9. PMID 17596953 DOI: 10.1016/j.nbd.2007.04.018  1
2007 Köfalvi A, Pereira MF, Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA. Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. British Journal of Pharmacology. 151: 551-63. PMID 17435795 DOI: 10.1038/sj.bjp.0707252  1
2007 Rebola N, Sachidhanandam S, Perrais D, Cunha RA, Mulle C. Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3987-93. PMID 17428973 DOI: 10.1523/JNEUROSCI.5182-06.2007  1
2007 Borycz J, Pereira MF, Melani A, Rodrigues RJ, Köfalvi A, Panlilio L, Pedata F, Goldberg SR, Cunha RA, Ferré S. Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments. Journal of Neurochemistry. 101: 355-63. PMID 17254024 DOI: 10.1111/j.1471-4159.2006.04386.x  1
2007 Duarte JM, Nogueira C, Mackie K, Oliveira CR, Cunha RA, Köfalvi A. Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats. Experimental Neurology. 204: 479-84. PMID 17222407 DOI: 10.1016/j.expneurol.2006.11.013  1
2007 Duarte JM, Cunha RA, Carvalho RA. Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy. Neuroscience. 144: 1305-13. PMID 17197104 DOI: 10.1016/j.neuroscience.2006.11.027  1
2007 Dall'Igna OP, Fett P, Gomes MW, Souza DO, Cunha RA, Lara DR. Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Experimental Neurology. 203: 241-5. PMID 17007839 DOI: 10.1016/j.expneurol.2006.08.008  1
2006 Rodrigues RJ, Almeida T, de Mendonça A, Cunha RA. Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus. Journal of Molecular Neuroscience : Mn. 30: 173-6. PMID 17192669 DOI: 10.1385/JMN:30:1:173  1
2006 Ciruela F, Ferré S, Casadó V, Cortés A, Cunha RA, Lluis C, Franco R. Heterodimeric adenosine receptors: a device to regulate neurotransmitter release. Cellular and Molecular Life Sciences : Cmls. 63: 2427-31. PMID 17058035 DOI: 10.1007/s00018-006-6216-2  1
2006 Degroot A, Köfalvi A, Wade MR, Davis RJ, Rodrigues RJ, Rebola N, Cunha RA, Nomikos GG. CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action. Molecular Pharmacology. 70: 1236-45. PMID 16855179 DOI: 10.1124/mol.106.024661  1
2006 Cunha GM, Canas PM, Oliveira CR, Cunha RA. Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress. Neuroscience. 141: 1775-81. PMID 16797134 DOI: 10.1016/j.neuroscience.2006.05.024  1
2006 Köfalvi A, Oliveira CR, Cunha RA. Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals. Neuroscience Letters. 403: 151-6. PMID 16672175 DOI: 10.1016/j.neulet.2006.04.030  1
2006 Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, ... Cunha RA, et al. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2080-7. PMID 16481441 DOI: 10.1523/JNEUROSCI.3574-05.2006  1
2006 Pereira DB, Rebola N, Rodrigues RJ, Cunha RA, Carvalho AP, Duarte CB. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of Neuroscience Research. 83: 832-44. PMID 16477614 DOI: 10.1002/jnr.20784  1
2006 Coelho JE, Rebola N, Fragata I, Ribeiro JA, de Mendonça A, Cunha RA. Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience. 138: 1195-203. PMID 16442739 DOI: 10.1016/j.neuroscience.2005.12.012  1
2005 Tebano MT, Martire A, Rebola N, Pepponi R, Domenici MR, Grò MC, Schwarzschild MA, Chen JF, Cunha RA, Popoli P. Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects. Journal of Neurochemistry. 95: 1188-200. PMID 16271052 DOI: 10.1111/j.1471-4159.2005.03455.x  0.44
2005 Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA. Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons. Neurochemistry International. 47: 317-25. PMID 16011860 DOI: 10.1016/j.neuint.2005.05.009  0.32
2005 Rodrigues RJ, Almeida T, Richardson PJ, Oliveira CR, Cunha RA. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6286-95. PMID 16000618 DOI: 10.1523/JNEUROSCI.0628-05.2005  0.32
2005 Rebola N, Porciúncula LO, Lopes LV, Oliveira CR, Soares-da-Silva P, Cunha RA. Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. Epilepsia. 46: 159-65. PMID 15987272 DOI: 10.1111/j.1528-1167.2005.01026.x  0.48
2005 Rebola N, Rodrigues RJ, Lopes LV, Richardson PJ, Oliveira CR, Cunha RA. Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus. Neuroscience. 133: 79-83. PMID 15893632 DOI: 10.1016/j.neuroscience.2005.01.054  0.48
2005 Pinto-Duarte A, Coelho JE, Cunha RA, Ribeiro JA, Sebastião AM. Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus. Journal of Neurochemistry. 93: 595-604. PMID 15836618 DOI: 10.1111/j.1471-4159.2005.03071.x  1
2005 Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM. Adenosine and brain function. International Review of Neurobiology. 63: 191-270. PMID 15797469 DOI: 10.1016/S0074-7742(05)63007-3  1
2005 Köfalvi A, Rodrigues RJ, Ledent C, Mackie K, Vizi ES, Cunha RA, Sperlágh B. Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2874-84. PMID 15772347 DOI: 10.1523/JNEUROSCI.4232-04.2005  0.44
2005 Rodrigues RJ, Alfaro TM, Rebola N, Oliveira CR, Cunha RA. Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. Journal of Neurochemistry. 92: 433-41. PMID 15659214 DOI: 10.1111/j.1471-4159.2004.02887.x  0.32
2004 Halldner L, Lopes LV, Daré E, Lindström K, Johansson B, Ledent C, Cunha RA, Fredholm BB. Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus. Naunyn-Schmiedeberg's Archives of Pharmacology. 370: 270-8. PMID 15378230 DOI: 10.1007/s00210-004-0970-1  1
2004 Lopes LV, Halldner L, Rebola N, Johansson B, Ledent C, Chen JF, Fredholm BB, Cunha RA. Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice. British Journal of Pharmacology. 141: 1006-14. PMID 14993095 DOI: 10.1038/sj.bjp.0705692  1
2004 Cunha RA, Ribeiro JA, Malva JO. Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid. Neurochemistry International. 44: 371-9. PMID 14643755 DOI: 10.1016/S0197-0186(03)00167-0  1
2003 Almeida T, Rodrigues RJ, de Mendonça A, Ribeiro JA, Cunha RA. Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Neuroscience. 122: 111-21. PMID 14596853 DOI: 10.1016/S0306-4522(03)00523-2  1
2003 Lopes LV, Rebola N, Pinheiro PC, Richardson PJ, Oliveira CR, Cunha RA. Adenosine A3 receptors are located in neurons of the rat hippocampus. Neuroreport. 14: 1645-8. PMID 14502093 DOI: 10.1097/01.wnr.0000088406.04452.44  0.48
2003 Rebola N, Coelho JE, Costenla AR, Lopes LV, Parada A, Oliveira CR, Soares-da-Silva P, de Mendonça A, Cunha RA. Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. The European Journal of Neuroscience. 18: 820-8. PMID 12925008 DOI: 10.1046/j.1460-9568.2003.02815.x  1
2003 Rebola N, Sebastião AM, de Mendonca A, Oliveira CR, Ribeiro JA, Cunha RA. Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. Journal of Neurophysiology. 90: 1295-303. PMID 12904509 DOI: 10.1152/jn.00896.2002  1
2003 Magalhães-Cardoso MT, Pereira MF, Oliveira L, Ribeiro JA, Cunha RA, Correia-de-Sá P. Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. The Journal of Physiology. 549: 399-408. PMID 12679375 DOI: 10.1113/jphysiol.2003.040410  1
2003 Almeida CG, de Mendonça A, Cunha RA, Ribeiro JA. Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices. Neuroscience Letters. 339: 127-30. PMID 12614911 DOI: 10.1016/S0304-3940(02)01478-7  1
2003 Fredholm BB, Cunha RA, Svenningsson P. Pharmacology of adenosine A2A receptors and therapeutic applications. Current Topics in Medicinal Chemistry. 3: 413-26. PMID 12570759  1
2003 Pinheiro PS, Rodrigues RJ, Silva AP, Cunha RA, Oliveira CR, Malva JO. Solubilization and immunological identification of presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus. Neuroscience Letters. 336: 97-100. PMID 12499049 DOI: 10.1016/S0304-3940(02)01217-X  1
2002 Cunha RA, Coelho JE, Costenla AR, Lopes LV, Parada A, de Mendonça A, Sebastião AM, Ribeiro JA. Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices. Pharmacology & Toxicology. 90: 208-13. PMID 12076316 DOI: 10.1034/j.1600-0773.2002.900407.x  1
2002 Lopes LV, Cunha RA, Kull B, Fredholm BB, Ribeiro JA. Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience. 112: 319-29. PMID 12044450 DOI: 10.1016/S0306-4522(02)00080-5  1
2002 Díaz-Hernández M, Pereira MF, Pintor J, Cunha RA, Ribeiro JA, Miras-Portugal MT. Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 301: 441-50. PMID 11961042 DOI: 10.1124/jpet.301.2.441  1
2001 Cunha RA, Constantino MD, Fonseca E, Ribeiro JA. Age-dependent decrease in adenosine A1 receptor binding sites in the rat brain. Effect of cis unsaturated free fatty acids. European Journal of Biochemistry / Febs. 268: 2939-47. PMID 11358511 DOI: 10.1046/j.1432-1327.2001.02183.x  1
2001 Cunha RA, Almeida T, Ribeiro JA. Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. Journal of Neurochemistry. 76: 372-82. PMID 11208900 DOI: 10.1046/j.1471-4159.2001.00095.x  1
2000 Cunha RA, Ribeiro JA. ATP as a presynaptic modulator. Life Sciences. 68: 119-37. PMID 11191632  1
2000 Sebastião AM, Cunha RA, de Mendonça A, Ribeiro JA. Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats. British Journal of Pharmacology. 131: 1629-34. PMID 11139440 DOI: 10.1038/sj.bjp.0703736  1
2000 Pereira MF, Hernández MD, Pintor J, Miras-Portugal MT, Cunha RA, Ribeiro JA. Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals. Brain Research. 879: 50-4. PMID 11011005 DOI: 10.1016/S0006-8993(00)02726-8  1
2000 Salgado AI, Cunha RA, Ribeiro JA. Facilitation by P(2) receptor activation of acetylcholine release from rat motor nerve terminals: interaction with presynaptic nicotinic receptors. Brain Research. 877: 245-50. PMID 10986338  0.48
2000 Cunha RA, Almeida T, Ribeiro JA. Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus. The Journal of Biological Chemistry. 275: 37572-81. PMID 10978314 DOI: 10.1074/jbc.M003011200  1
2000 Cunha RA, Ribeiro JA. Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation. Neuroscience Letters. 289: 127-30. PMID 10904136  0.48
2000 Pereira MF, Cunha RA, Ribeiro JA. Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats. Neurochemistry International. 36: 563-6. PMID 10771114  0.48
2000 Cunha RA, Ribeiro JA. Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals. Neuropharmacology. 39: 1156-67. PMID 10760359  0.48
2000 Cunha RA, Malva JO, Ribeiro JA. Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [(3)H]GABA release. Febs Letters. 469: 159-62. PMID 10713263  0.48
2000 Cunha RA, Brendel P, Zimmermann H, Ribeiro JA. Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus. Journal of Neurochemistry. 74: 334-8. PMID 10617137  0.48
1999 Lopes LV, Cunha RA, Ribeiro JA. Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats. Journal of Neurophysiology. 82: 3196-203. PMID 10601453  0.48
1999 Lopes LV, Cunha RA, Ribeiro JA. ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A(1) receptor responses. European Journal of Pharmacology. 383: 395-8. PMID 10594334  0.48
1999 Sebastião AM, Cunha RA, Cascalheira JF, Ribeiro JA. Adenine nucleotides as inhibitors of synaptic transmission: role of localised ectonucleotidases. Progress in Brain Research. 120: 183-92. PMID 10550997  1
1999 Lopes LV, Cunha RA, Ribeiro JA. Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats. Journal of Neurochemistry. 73: 1733-8. PMID 10501222  0.48
1999 Cunha RA, Malva JO, Ribeiro JA. Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus. Molecular Pharmacology. 56: 429-33. PMID 10419564  0.48
1999 Cunha RA, Constantino MD, Ribeiro JA. G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 359: 295-302. PMID 10344528  0.48
1999 Cunha RA, Ribeiro JA. Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes. The European Journal of Neuroscience. 11: 2171-4. PMID 10336686  0.48
1999 Almeida T, Cunha RA, Ribeiro JA. Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus. Brain Research. 826: 104-11. PMID 10216201  0.48
1998 Cunha RA. On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology. Trends in Neurosciences. 21: 286; author reply 28. PMID 9683318  1
1998 Cunha RA, Sebastião AM, Ribeiro JA. Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1987-95. PMID 9482785  0.48
1997 Gonçalves ML, Cunha RA, Ribeiro JA. Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neuroscience Letters. 238: 73-7. PMID 9464658  0.48
1997 Cunha RA, Constantino MD, Ribeiro JA. ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. British Journal of Pharmacology. 122: 1279-84. PMID 9421273 DOI: 10.1038/sj.bjp.0701507  0.48
1997 Cunha RA, Constantino MD, Ribeiro JA. Inhibition of [3H] gamma-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes. European Journal of Pharmacology. 323: 167-72. PMID 9128835  0.48
1996 Ribeiro JA, Cunha RA, Correia-de-Sá P, Sebastião AM. Purinergic regulation of acetylcholine release. Progress in Brain Research. 109: 231-41. PMID 9009712  1
1996 Cunha RA, Correia-de-Sá P, Sebastião AM, Ribeiro JA. Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides. British Journal of Pharmacology. 119: 253-60. PMID 8886406  0.48
1996 Cunha RA, Vizi ES, Ribeiro JA, Sebastião AM. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. Journal of Neurochemistry. 67: 2180-7. PMID 8863529  0.48
1996 Cunha RA, Johansson B, Constantino MD, Sebastião AM, Fredholm BB. Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 353: 261-71. PMID 8692280  1
1995 Cunha RA, Constantino MC, Sebastião AM, Ribeiro JA. Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport. 6: 1583-8. PMID 7579154  0.48
1995 Malva JO, Ambrósio AF, Cunha RA, Ribeiro JA, Carvalho AP, Carvalho CM. A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion. Neuroscience Letters. 185: 83-6. PMID 7538212  0.48
1995 Cunha RA, Johansson B, Fredholm BB, Ribeiro JA, Sebastião AM. Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neuroscience Letters. 196: 41-4. PMID 7501252  1
1994 Cunha RA, Milusheva E, Vizi ES, Ribeiro JA, Sebastião AM. Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus. Journal of Neurochemistry. 63: 207-14. PMID 8207430  0.48
1994 Cunha RA, Ribeiro JA, Sebastião AM. Purinergic modulation of the evoked release of [3H]acetylcholine from the hippocampus and cerebral cortex of the rat: role of the ectonucleotidases. The European Journal of Neuroscience. 6: 33-42. PMID 8130931  0.48
1994 Cunha RA, Johansson B, van der Ploeg I, Sebastião AM, Ribeiro JA, Fredholm BB. Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Brain Research. 649: 208-16. PMID 7953635  1
1993 Cunha RA, Sebastião AM. Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog. PflüGers Archiv : European Journal of Physiology. 424: 503-10. PMID 8255734  0.44
1992 Cunha RA, Sebastião AM, Ribeiro JA. Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat. Journal of Neurochemistry. 59: 657-66. PMID 1629736  0.48
1991 Cunha RA, Sebastião AM. Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog. European Journal of Pharmacology. 197: 83-92. PMID 1654262  0.44
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