| Year |
Citation |
Score |
| 2024 |
Lahiri DK, Sokol DK. Alzheimer's Drugs APPlication for Down syndrome? Ageing Research Reviews. 102281. PMID 38513771 DOI: 10.1016/j.arr.2024.102281 |
0.335 |
|
| 2023 |
Schmued L, Maloney B, Schmued C, Lahiri DK. Treatment with 1, 10 Phenanthroline-5-Amine Reduced Amyloid Burden in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 38073385 DOI: 10.3233/JAD-221285 |
0.333 |
|
| 2020 |
Westmark CJ, Maloney B, Alisch RS, Sokol DK, Lahiri DK. FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N-Methyladenosine Dataset. Scientific Reports. 10: 10781. PMID 32612155 DOI: 10.1038/S41598-020-66394-Y |
0.343 |
|
| 2020 |
Dorszewska J, Lahiri DK. Diversity of Molecular Factors in Alzheimer's Disease. Current Alzheimer Research. 17: 205-207. PMID 32442077 DOI: 10.2174/156720501703200518081524 |
0.377 |
|
| 2020 |
Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Translational Psychiatry. 10: 81. PMID 32123156 DOI: 10.1038/S41398-020-0757-2 |
0.359 |
|
| 2020 |
Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Translational Psychiatry. 10: 47. PMID 32066688 DOI: 10.1038/S41398-020-0709-X |
0.441 |
|
| 2020 |
Chopra N, Wang R, Maloney B, Nho K, Beck JS, Pourshafie N, Niculescu A, Saykin AJ, Rinaldi C, Counts SE, Lahiri DK. MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties. Molecular Psychiatry. PMID 31942037 DOI: 10.1038/S41380-019-0610-2 |
0.425 |
|
| 2019 |
Maloney B, Balaraman Y, Liu Y, Chopra N, Edenberg HJ, Kelsoe J, Nurnberger JI, Lahiri DK. Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. Scientific Reports. 9: 18261. PMID 31797941 DOI: 10.1016/J.Biopsych.2020.02.779 |
0.309 |
|
| 2019 |
Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A, Robertson H, Jones T, Strasburger A, Williams A, Kurian SM, Lamb B, Shekhar A, Lahiri DK, Saykin AJ. Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs. Molecular Psychiatry. PMID 31792364 DOI: 10.1038/S41380-019-0602-2 |
0.38 |
|
| 2019 |
Lahiri DK. Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD. Current Alzheimer Research. 16: 279-280. PMID 31104627 DOI: 10.2174/156720501604190424114752 |
0.406 |
|
| 2019 |
Sokol DK, Maloney B, Westmark CJ, Lahiri DK. Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder. Frontiers in Psychiatry. 10: 165. PMID 31024350 DOI: 10.3389/Fpsyt.2019.00165 |
0.388 |
|
| 2019 |
Nudelman KNH, McDonald BC, Lahiri DK, Saykin AJ. Biological Hallmarks of Cancer in Alzheimer's Disease. Molecular Neurobiology. PMID 30993533 DOI: 10.1007/S12035-019-1591-5 |
0.43 |
|
| 2019 |
Duffy KB, Ray B, Lahiri DK, Tilmont EM, Tinkler GP, Herbert RL, Greig NH, Ingram DK, Ottinger MA, Mattison JA. Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta). Journal of Alzheimer's Disease : Jad. PMID 30689563 DOI: 10.3233/Jad-180487 |
0.413 |
|
| 2019 |
Wang R, Maloney B, Lahiri DK. P4-102: THE REPRESSOR ELEMENT 1-SILENCING TRANSCRIPTION FACTOR (REST) IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1314-P1314. DOI: 10.1016/J.Jalz.2019.06.3763 |
0.363 |
|
| 2019 |
Wang R, Chopra N, Maloney B, Lahiri DK. P3-150: DYSREGULATION OF THE Aβ DEGRADING ENZYME NEPRILYSIN (MME) COULD CONTRIBUTE TO ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P989-P989. DOI: 10.1016/J.Jalz.2019.06.3178 |
0.412 |
|
| 2019 |
Lecca D, Bader M, Tweedie D, Lahiri DK, Becker RE, Pick C, Hoffman AF, Lupica CR, Greig NH. P3-056: PROTECTIVE EFFECTS OF (-)-PHENSERINE (PHEN) IN ALZHEIMER'S DISEASE (AD) AND MILD TRAUMATIC BRAIN INJURY (MTBI) MURINE MODELS Alzheimer's & Dementia. 15: P947-P947. DOI: 10.1016/J.Jalz.2019.06.3083 |
0.401 |
|
| 2019 |
Niculescu AB, Le-Niculescu H, Wang S, Lamb BT, Lahiri DK, Saykin AJ. P2-260: BLOOD BIOMARKERS FOR MEMORY: TOWARDS EARLY DETECTION OF RISK FOR ALZHEIMER DISEASE, PHARMACOGENOMICS, AND REPURPOSED DRUGS Alzheimer's & Dementia. 15: P684-P685. DOI: 10.1016/J.Jalz.2019.06.2667 |
0.311 |
|
| 2019 |
Srinivasan M, Hickman D, Lahiri DK. P1-088: NOVEL NUCLEAR FACTOR-KAPPAB TARGETING PEPTIDE SUPPRESSES PATHOLOGY IN PRE-CLINICAL MODELS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P268-P268. DOI: 10.1016/J.Jalz.2019.06.113 |
0.369 |
|
| 2019 |
Niculescu A, Le-Niculescu H, Roseberry K, Wang S, Lahiri D, Saykin A. O45. Blood Biomarkers for Possible Early Detection of Risk for Alzheimer Disease (AD) Biological Psychiatry. 85: S124. DOI: 10.1016/J.Biopsych.2019.03.310 |
0.363 |
|
| 2018 |
Witek E, Hickman D, Lahiri DK, Srinivasan M. Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation. Frontiers in Aging Neuroscience. 10: 432. PMID 30740047 DOI: 10.3389/Fnagi.2018.00432 |
0.325 |
|
| 2018 |
Long JM, Maloney B, Rogers JT, Lahiri DK. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease. Molecular Psychiatry. PMID 30470799 DOI: 10.1038/S41380-018-0266-3 |
0.571 |
|
| 2018 |
Srinivasan M, Lahiri N, Thyagarajan A, Witek E, Hickman D, Lahiri DK. Nuclear factor-kappa B: Glucocorticoid-induced leucine zipper interface analogs suppress pathology in an Alzheimer's disease model. Alzheimer's & Dementia (New York, N. Y.). 4: 488-498. PMID 30338290 DOI: 10.1016/J.Trci.2018.04.004 |
0.38 |
|
| 2018 |
Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, et al. Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin. Journal of Neurochemistry. PMID 30152072 DOI: 10.1111/Jnc.14580 |
0.312 |
|
| 2018 |
Becker RE, Greig NH, Lahiri DK, Bledsoe J, Majercik S, Ballard C, Aarsland D, Schneiderh LS, Flanagan D, Govindarajani R, Sano M, Ferrucci L, Kapogiannisk D. (-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer's Disease. Current Alzheimer Research. PMID 29318971 DOI: 10.2174/1567205015666180110120026 |
0.452 |
|
| 2017 |
Lahiri DK, Maloney B, Greig NH. Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders. The Journal of Biological Chemistry. 292: 20353. PMID 29222197 DOI: 10.1074/Jbc.L117.000502 |
0.311 |
|
| 2017 |
Bayon BL, Maloney B, Chopra N, White FA, Xu X, Ratan RR, Lahiri DK. [O4-06-01]: SP1-MODULATING COMPOUNDS AS A NOVEL DRUG TARGET FOR ALZHEIMER'S DISEASE (AD) Alzheimer's & Dementia. 13: P1241-P1241. DOI: 10.1016/J.Jalz.2017.07.448 |
0.383 |
|
| 2017 |
Lahiri DK, Maloney B, Ray B, Sokol DK. [P2-159]: DOES THE “BIOCHEMICAL INVERSION” OF ALZHEIMER's DISEASE AND AUTISM SPECTRUM DISORDER PROVIDE LATE-LIFE PROTECTION FROM AN EARLY-LIFE CONDITION? Alzheimer's & Dementia. 13: P668-P669. DOI: 10.1016/J.Jalz.2017.06.810 |
0.319 |
|
| 2017 |
Bayon BL, Nho K, Saykin AJ, Srinivasan M, Lahiri DK. [P4-030]: ROLE OF SP1 AND OTHER TRANSCRIPTION FACTORS (TFS) IN ALZHEIMER's DISEASE (AD) Alzheimer's & Dementia. 13: P1266-P1267. DOI: 10.1016/J.Jalz.2017.06.1894 |
0.412 |
|
| 2017 |
Nudelman KN, Nho K, McDonald BC, Lahiri DK, Bennett DA, Saykin AJ. [P3-087]: MICRORNA AND GENE NETWORKS UNDERLYING THE INVERSE ASSOCIATION OF CANCER AND ALZHEIMER's DISEASE Alzheimer's & Dementia. 13: P966-P966. DOI: 10.1016/J.Jalz.2017.06.1297 |
0.341 |
|
| 2016 |
Srinivasan M, Lahiri DK. Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease. Molecular Neurobiology. PMID 27889894 DOI: 10.1007/S12035-016-0277-5 |
0.331 |
|
| 2016 |
Srinivasan M, Bayon B, Chopra N, Lahiri DK. Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells. Plos One. 11: e0160314. PMID 27764084 DOI: 10.1371/Journal.Pone.0160314 |
0.41 |
|
| 2016 |
Decourt B, Lahiri DK, Sabbagh MN. Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease. Current Alzheimer Research. PMID 27697064 DOI: 10.2174/1567205013666160930110551 |
0.418 |
|
| 2016 |
Westmark CJ, Sokol DK, Maloney B, Lahiri DK. Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism. Molecular Psychiatry. PMID 27573877 DOI: 10.1038/Mp.2016.134 |
0.443 |
|
| 2016 |
Erickson CA, Wink LK, Baindu B, Ray B, Schaefer TL, Pedapati EV, Lahiri D. Analysis of peripheral amyloid precursor protein in Angelman Syndrome. American Journal of Medical Genetics. Part A. PMID 27327493 DOI: 10.1002/Ajmg.A.37811 |
0.35 |
|
| 2016 |
Maloney B, Lahiri DK. Epigenetics of dementia: understanding the disease as a transformation rather than a state. The Lancet. Neurology. 15: 760-74. PMID 27302240 DOI: 10.1016/S1474-4422(16)00065-X |
0.341 |
|
| 2016 |
Ray B, Sokol DK, Maloney B, Lahiri DK. Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue. Scientific Reports. 6: 26052. PMID 27212113 DOI: 10.1038/Srep26052 |
0.417 |
|
| 2016 |
Bali P, Lahiri DK, Banik A, Nehru B, Anand A. Potential for Stem Cells Therapy in Alzheimer's disease: Do neurotrophic factors play critical role? Current Alzheimer Research. PMID 26971940 DOI: 10.2174/1567205013666160314145347 |
0.336 |
|
| 2016 |
Shah K, Lahiri DK. A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5. Molecular Neurobiology. PMID 26944284 DOI: 10.1007/S12035-016-9792-7 |
0.336 |
|
| 2016 |
Huang Y, Lahiri DK. Editorial: Translational Alzheimer's Disease Research. Current Alzheimer Research. 13: 214. PMID 26906353 DOI: 10.2174/156720501303160217102238 |
0.381 |
|
| 2016 |
Lahiri DK, Maloney B, Ray B, Sokol DK. P4-305: Novel Parallels and Distinctions Among App Metabolite Pathways in Alzheimer's Disease and Neurodevelopmental Disorders Alzheimer's & Dementia. 12: P1150-P1150. DOI: 10.1016/J.Jalz.2016.07.048 |
0.386 |
|
| 2015 |
Sarkar S, Raymick J, Ray B, Lahiri DK, Paule MG, Schmued L. Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice. Current Alzheimer Research. 12: 837-46. PMID 26510980 DOI: 10.2174/156720501209151019105647 |
0.439 |
|
| 2015 |
Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y, Mudher A, Padjen AL, Mukaetova-Ladinska E, Ihara M, Srivastava S, Padma Srivastava MV, Masters CL, et al. Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?1. Journal of Alzheimer's Disease : Jad. 47: 815-43. PMID 26401762 DOI: 10.3233/Jad-150136 |
0.41 |
|
| 2015 |
Srinivasan M, Lahiri DK. Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis. Expert Opinion On Therapeutic Targets. 19: 471-87. PMID 25652642 DOI: 10.1517/14728222.2014.989834 |
0.387 |
|
| 2015 |
Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Current Alzheimer Research. 12: 32-46. PMID 25523424 DOI: 10.2174/1567205012666141218140953 |
0.459 |
|
| 2015 |
Lahiri DK, Maloney B, Long J, Chopra N, Bayon BL, Greig NH, Sambamurti K, Spence J, Ray B. P2-048: Does the mini-mental state examination (MMSE) measure a deeper biological process? modeling mmse score versus three selected mirna levels may reveal pathological roles in Alzheimer's disease progression Alzheimer's & Dementia. 11: P499-P500. DOI: 10.1016/J.Jalz.2015.06.584 |
0.548 |
|
| 2015 |
Sambamurti K, Greig NH, Baranello RJ, Chinnakkanu P, Lahiri DK, Padmaraju V. P4-156: Methionine restriction leads to Aβ reduction and neuroprotection: Implications in Alzheimer's disease pathogenesis and prevention Alzheimer's & Dementia. 11: P838-P839. DOI: 10.1016/J.Jalz.2015.06.1863 |
0.443 |
|
| 2014 |
Srinivasan M, Blackburn C, Lahiri DK. Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. Drug Design, Development and Therapy. 8: 2409-21. PMID 25584020 DOI: 10.2147/Dddt.S59722 |
0.322 |
|
| 2014 |
Erickson CA, Ray B, Maloney B, Wink LK, Bowers K, Schaefer TL, McDougle CJ, Sokol DK, Lahiri DK. Impact of acamprosate on plasma amyloid-β precursor protein in youth: a pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker. Journal of Psychiatric Research. 59: 220-8. PMID 25300441 DOI: 10.1016/J.Jpsychires.2014.07.011 |
0.306 |
|
| 2014 |
Ray B, Chopra N, Long JM, Lahiri DK. Human primary mixed brain cultures: preparation, differentiation, characterization and application to neuroscience research. Molecular Brain. 7: 63. PMID 25223359 DOI: 10.1186/S13041-014-0063-0 |
0.526 |
|
| 2014 |
Counts SE, Lahiri DK. Overview of immunotherapy in Alzheimer's disease (AD) and mechanisms of IVIG neuroprotection in preclinical models of AD. Current Alzheimer Research. 11: 623-5. PMID 25156573 DOI: 10.2174/156720501107140815102453 |
0.322 |
|
| 2014 |
Greig NH, Sambamurti K, Lahiri DK, Becker RE. Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment. Annals of Neurology. 76: 629-30. PMID 25146731 DOI: 10.1002/Ana.24254 |
0.431 |
|
| 2014 |
Lahiri DK, Ray B. Intravenous immunoglobulin treatment preserves and protects primary rat hippocampal neurons and primary human brain cultures against oxidative insults. Current Alzheimer Research. 11: 645-54. PMID 25115544 DOI: 10.2174/1567205011666140812113851 |
0.387 |
|
| 2014 |
Shah K, Lahiri DK. Cdk5 activity in the brain - multiple paths of regulation. Journal of Cell Science. 127: 2391-400. PMID 24879856 DOI: 10.1242/Jcs.147553 |
0.368 |
|
| 2014 |
Modgil S, Lahiri DK, Sharma VL, Anand A. Role of early life exposure and environment on neurodegeneration: implications on brain disorders. Translational Neurodegeneration. 3: 9. PMID 24847438 DOI: 10.1186/2047-9158-3-9 |
0.37 |
|
| 2014 |
Counts SE, Ray B, Mufson EJ, Perez SE, He B, Lahiri DK. Intravenous immunoglobulin (IVIG) treatment exerts antioxidant and neuropreservatory effects in preclinical models of Alzheimer's disease. Journal of Clinical Immunology. 34: S80-5. PMID 24760109 DOI: 10.1007/S10875-014-0020-9 |
0.411 |
|
| 2014 |
Greig NH, Lahiri DK. Advances in understanding Alzheimer's disease, and the contributions of current Alzheimer research: ten years on and beyond. Current Alzheimer Research. 11: 107-9. PMID 24661146 DOI: 10.2174/156720501102140313162901 |
0.365 |
|
| 2014 |
Zhang YH, Mann D, Raymick J, Sarkar S, Paule MG, Lahiri DK, Dumas M, Bell-Cohen A, Schmued LC. K114 inhibits A-beta aggregation and inflammation in vitro and in vivo in AD/Tg mice. Current Alzheimer Research. 11: 299-308. PMID 24552157 DOI: 10.2174/1567205011666140220125324 |
0.435 |
|
| 2014 |
Lahiri DK, Maloney B, Long JM, Greig NH. Lessons from a BACE1 inhibitor trial: off-site but not off base. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S411-9. PMID 24530026 DOI: 10.1016/J.Jalz.2013.11.004 |
0.602 |
|
| 2014 |
Reale M, Di Nicola M, Velluto L, D'Angelo C, Costantini E, Lahiri DK, Kamal MA, Yu QS, Greig NH. Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway. Current Alzheimer Research. 11: 608-22. PMID 24359497 DOI: 10.2174/1567205010666131212113218 |
0.454 |
|
| 2014 |
Long JM, Ray B, Lahiri DK. MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. The Journal of Biological Chemistry. 289: 5184-98. PMID 24352696 DOI: 10.1074/Jbc.M113.518241 |
0.587 |
|
| 2014 |
Perez FP, Bose D, Maloney B, Nho K, Shah K, Lahiri DK. Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process. Journal of Alzheimer's Disease : Jad. 40: 1-17. PMID 24326519 DOI: 10.3233/Jad-131544 |
0.361 |
|
| 2014 |
Bayon BL, Lahiri DK. P1-066: TREATMENT WITH SP1 INHIBITING DRUGS MODULATES APP AND BACE1 LEVELS IN HUMAN CELLS: IMPLICATION IN TESTING A NOVEL TARGET FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P327-P327. DOI: 10.1016/J.Jalz.2014.05.302 |
0.392 |
|
| 2014 |
Lahiri DK, Long JM. P4-219: MICRORNA-339-5P IS DYSREGULATED IN ALZHEIMER'S DISEASE AND IS INVERSELY PROPORTIONAL TO BACE1 EXPRESSION: IMPLICATION IN TESTING NOVEL DRUG TARGETS Alzheimer's & Dementia. 10: P868-P868. DOI: 10.1016/J.Jalz.2014.05.1737 |
0.552 |
|
| 2013 |
Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, Huang X, Rogers JT. Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. Plos One. 8: e65978. PMID 23935819 DOI: 10.1371/Journal.Pone.0065978 |
0.392 |
|
| 2013 |
Lahiri DK, Sokol DK, Erickson C, Ray B, Ho CY, Maloney B. Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway. Frontiers in Cellular Neuroscience. 7: 94. PMID 23801940 DOI: 10.3389/Fncel.2013.00094 |
0.382 |
|
| 2013 |
Zhang YH, Raymick J, Sarkar S, Lahiri DK, Ray B, Holtzman D, Dumas M, Schmued LC. Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease. Current Alzheimer Research. 10: 494-506. PMID 23627708 DOI: 10.2174/1567205011310050005 |
0.437 |
|
| 2013 |
Lahiri DK, Maloney B, Rogers JT, Ge YW. PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE). Bmc Genomics. 14: 68. PMID 23368879 DOI: 10.1186/1471-2164-14-68 |
0.471 |
|
| 2013 |
Lahiri DK. Progress of "Current Alzheimer Research" and future direction. Current Alzheimer Research. 10: 1-3. PMID 23368431 DOI: 10.2174/1567205011310010001 |
0.328 |
|
| 2013 |
Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 12: 117-28. PMID 23360256 DOI: 10.2174/1871523011312020003 |
0.402 |
|
| 2013 |
Bayon B, Lahiri D, Bailey J. P1-399: BACE1 gene regulation: A novel drug target in Alzheimer's disease Alzheimer's & Dementia. 9: P304-P304. DOI: 10.1016/J.Jalz.2013.05.626 |
0.365 |
|
| 2013 |
Lahiri D, Long J, Chopra N, Ray B. O5-06-02: MicroRNA-346 stimulates APP expression by blockading an iron response element in the APP 5'-UTR: A novel therapeutic target for Alzheimer's disease (AD) Alzheimer's & Dementia. 9: P839-P839. DOI: 10.1016/J.Jalz.2013.04.500 |
0.598 |
|
| 2012 |
Holohan KN, Lahiri DK, Schneider BP, Foroud T, Saykin AJ. Functional microRNAs in Alzheimer's disease and cancer: differential regulation of common mechanisms and pathways. Frontiers in Genetics. 3: 323. PMID 23335942 DOI: 10.3389/Fgene.2012.00323 |
0.342 |
|
| 2012 |
Lahiri DK. Prions: a piece of the puzzle? Science (New York, N.Y.). 337: 1172. PMID 22955815 DOI: 10.1126/Science.337.6099.1172-A |
0.425 |
|
| 2012 |
Ray B, Bailey JA, Simon JR, Lahiri DK. High-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in neuronal cultures for mechanistic and drug discovery studies. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 7.23. PMID 22752895 DOI: 10.1002/0471142301.Ns0723S60 |
0.31 |
|
| 2012 |
Long JM, Ray B, Lahiri DK. MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. The Journal of Biological Chemistry. 287: 31298-310. PMID 22733824 DOI: 10.1074/Jbc.M112.366336 |
0.56 |
|
| 2012 |
Tweedie D, Ferguson RA, Fishman K, Frankola KA, Van Praag H, Holloway HW, Luo W, Li Y, Caracciolo L, Russo I, Barlati S, Ray B, Lahiri DK, Bosetti F, Greig NH, et al. Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. Journal of Neuroinflammation. 9: 106. PMID 22642825 DOI: 10.1186/1742-2094-9-106 |
0.438 |
|
| 2012 |
Bailey JA, Lahiri DK. Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer's disease versus controls. Journal of Neurochemistry. 122: 672-80. PMID 22607230 DOI: 10.1111/J.1471-4159.2012.07793.X |
0.327 |
|
| 2012 |
Lahiri DK, Maloney B. The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders. Journal of Alzheimer's Disease : Jad. 30: S15-30. PMID 22555376 DOI: 10.3233/Jad-2012-120373 |
0.332 |
|
| 2012 |
Li Y, Chigurupati S, Holloway HW, Mughal M, Tweedie D, Bruestle DA, Mattson MP, Wang Y, Harvey BK, Ray B, Lahiri DK, Greig NH. Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis. Plos One. 7: e32008. PMID 22384126 DOI: 10.1371/Journal.Pone.0032008 |
0.319 |
|
| 2012 |
Zawia NH, Lahiri DK. Epigenetics: a paradigm shift in understanding Alzheimer's disease. Current Alzheimer Research. 9: 525-6. PMID 22364524 DOI: 10.2174/156720512800617973 |
0.39 |
|
| 2012 |
Maloney B, Lahiri DK. Structural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease. Gene. 501: 63-78. PMID 22310385 DOI: 10.1016/J.Gene.2012.01.049 |
0.39 |
|
| 2012 |
Maloney B, Sambamurti K, Zawia N, Lahiri DK. Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model. Current Alzheimer Research. 9: 589-99. PMID 22300406 DOI: 10.2174/156720512800617955 |
0.438 |
|
| 2012 |
Bihaqi SW, Schumacher A, Maloney B, Lahiri DK, Zawia NH. Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm. Current Alzheimer Research. 9: 574-88. PMID 22300405 DOI: 10.2174/156720512800617982 |
0.372 |
|
| 2012 |
Long JM, Lahiri DK. Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders. Experimental Neurology. 235: 402-18. PMID 22245616 DOI: 10.1016/J.Expneurol.2011.12.043 |
0.509 |
|
| 2012 |
Olivares D, Deshpande VK, Shi Y, Lahiri DK, Greig NH, Rogers JT, Huang X. N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Current Alzheimer Research. 9: 746-58. PMID 21875407 DOI: 10.2174/156720512801322564 |
0.354 |
|
| 2012 |
Lahiri D, Long J, Ray B. P4-316: A specific microRNA (miR-339-5p) is reduced in Alzheimer's disease brain and able to lower BACE1 and BETA-AMYLOID peptide levels in human fetal brain cultures, suggesting a novel drug target for ALZHEIMER'S Alzheimer's & Dementia. 8: S769-S769. DOI: 10.1016/J.Jalz.2013.08.097 |
0.607 |
|
| 2012 |
Ray B, Bailey J, Nelson P, Greig N, Lahiri D. P1-215: Rivastigmine promotes APP processing via α-secretase pathway: Studies from neuron culture and animal model to postmortem brain tissues and its implications in Alzheimer's disease (AD) Alzheimer's & Dementia. 8: P182-P183. DOI: 10.1016/J.Jalz.2012.05.494 |
0.436 |
|
| 2011 |
Bailey JA, Ray B, Greig NH, Lahiri DK. Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. Plos One. 6: e21954. PMID 21799757 DOI: 10.1371/Journal.Pone.0021954 |
0.43 |
|
| 2011 |
Ray B, Long JM, Sokol DK, Lahiri DK. Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker. Plos One. 6: e20405. PMID 21731612 DOI: 10.1371/Journal.Pone.0020405 |
0.539 |
|
| 2011 |
Ray B, Chauhan NB, Lahiri DK. The "aged garlic extract:" (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD). Current Medicinal Chemistry. 18: 3306-13. PMID 21728972 DOI: 10.2174/092986711796504664 |
0.465 |
|
| 2011 |
Long JM, Lahiri DK. Current drug targets for modulating Alzheimer's amyloid precursor protein: role of specific micro-RNA species. Current Medicinal Chemistry. 18: 3314-21. PMID 21728971 DOI: 10.2174/092986711796504592 |
0.57 |
|
| 2011 |
Bailey JA, Maloney B, Ge YW, Lahiri DK. Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis. Gene. 488: 13-22. PMID 21708232 DOI: 10.1016/J.Gene.2011.06.017 |
0.45 |
|
| 2011 |
Maloney B, Lahiri DK. The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif. Gene. 488: 1-12. PMID 21699964 DOI: 10.1016/J.Gene.2011.06.004 |
0.421 |
|
| 2011 |
Sokol DK, Maloney B, Long JM, Ray B, Lahiri DK. Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links. Neurology. 76: 1344-52. PMID 21482951 DOI: 10.1212/Wnl.0B013E3182166Dc7 |
0.621 |
|
| 2011 |
Ray B, Gaskins DL, Sajdyk TJ, Spence JP, Fitz SD, Shekhar A, Lahiri DK. Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteins in the prefrontal cortex of rats. Neuroscience. 184: 139-50. PMID 21477639 DOI: 10.1016/J.Neuroscience.2011.03.067 |
0.347 |
|
| 2011 |
Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from γ-secretase inhibitors. Journal of Neurochemistry. 117: 359-74. PMID 21320126 DOI: 10.1111/J.1471-4159.2011.07213.X |
0.452 |
|
| 2011 |
Lahiri DK. Application of a multidisciplinary approach to Alzheimer's disease to develop novel drug targets by integrating biomarkers, imaging, genetic and molecular strategies. Current Alzheimer Research. 8: 1-3. PMID 21265731 DOI: 10.2174/156720511794604534 |
0.325 |
|
| 2011 |
Long JM, Lahiri DK. MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed. Biochemical and Biophysical Research Communications. 404: 889-95. PMID 21172309 DOI: 10.1016/J.Bbrc.2010.12.053 |
0.538 |
|
| 2011 |
Ray B, Chauhan NB, Lahiri DK. Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. Journal of Neurochemistry. 117: 388-402. PMID 21166677 DOI: 10.1111/J.1471-4159.2010.07145.X |
0.428 |
|
| 2011 |
Ray B, Bisht S, Maitra A, Maitra A, Lahiri DK. Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 23: 61-77. PMID 20930270 DOI: 10.3233/Jad-2010-101374 |
0.432 |
|
| 2011 |
Ray B, Reyes PF, Lahiri DK. Biochemical studies in Normal Pressure Hydrocephalus (NPH) patients: change in CSF levels of amyloid precursor protein (APP), amyloid-beta (Aβ) peptide and phospho-tau. Journal of Psychiatric Research. 45: 539-47. PMID 20828718 DOI: 10.1016/J.Jpsychires.2010.07.011 |
0.436 |
|
| 2011 |
Lahiri DK, Long JM, Ray B, Sokol D. Biochemical evidence for the dysregulation of Alzheimer’s Amyloid Precursor Protein (APP) expression and metabolism in Fragile X Syndrome (FXS) and severe autism F1000research. 2. DOI: 10.7490/F1000Research.1597.1 |
0.535 |
|
| 2011 |
Lahiri D, Bailey J, Ray B. P3-441: Rapamycin treatment reverses memantine-mediated increase in synaptic signaling proteins in degenerating primary neurons: Implications in Alzheimer's disease Alzheimer's & Dementia. 7: S656-S656. DOI: 10.1016/J.Jalz.2011.05.1885 |
0.369 |
|
| 2011 |
Long J, Lahiri D. P3-157: A novel microRNA interaction relevant to alzheimer's disease pathogenesis and drug target discovery: miR-346 induces expression of amyloid precursor protein Alzheimer's & Dementia. 7: S566-S567. DOI: 10.1016/J.Jalz.2011.05.1597 |
0.586 |
|
| 2010 |
Lahiri DK. 'Current Alzheimer research' helps accelerate the progress of the field. Current Alzheimer Research. 7: 1-2. PMID 21418013 DOI: 10.2174/156720510790274419 |
0.307 |
|
| 2010 |
Bandyopadhyay S, Huang X, Lahiri DK, Rogers JT. Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opinion On Therapeutic Targets. 14: 1177-97. PMID 20942746 DOI: 10.1517/14728222.2010.525352 |
0.449 |
|
| 2010 |
Liu D, Pitta M, Lee JH, Ray B, Lahiri DK, Furukawa K, Mughal M, Jiang H, Villarreal J, Cutler RG, Greig NH, Mattson MP. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 22: 443-57. PMID 20847430 DOI: 10.3233/Jad-2010-101017 |
0.382 |
|
| 2010 |
Lahiri DK, Maloney B. Beyond the signaling effect role of amyloid-ß42 on the processing of APP, and its clinical implications. Experimental Neurology. 225: 51-4. PMID 20451519 DOI: 10.1016/J.Expneurol.2010.04.018 |
0.44 |
|
| 2010 |
Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, Tweedie D, Perry T, Mattson MP, Kapogiannis D, Sambamurti K, Lahiri DK, Greig NH. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1205-19. PMID 20308787 DOI: 10.3233/Jad-2010-1314 |
0.432 |
|
| 2010 |
Lahiri DK, Maloney B. The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps. Experimental Gerontology. 45: 291-6. PMID 20064601 DOI: 10.1016/J.Exger.2010.01.001 |
0.392 |
|
| 2010 |
Ray B, Banerjee PK, Greig NH, Lahiri DK. Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cells. Neuroscience Letters. 470: 1-5. PMID 19948208 DOI: 10.1016/J.Neulet.2009.11.016 |
0.403 |
|
| 2010 |
Bailey JA, Lahiri DK. A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer's disease. Journal of Neurochemistry. 112: 843-53. PMID 19912467 DOI: 10.1111/J.1471-4159.2009.06490.X |
0.466 |
|
| 2010 |
Alley GM, Bailey JA, Chen D, Ray B, Puli LK, Tanila H, Banerjee PK, Lahiri DK. Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice. Journal of Neuroscience Research. 88: 143-54. PMID 19642202 DOI: 10.1002/Jnr.22172 |
0.417 |
|
| 2010 |
Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Pérez-Tur J, Lahiri DK. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 185-201. PMID 19504470 DOI: 10.1002/Ajmg.B.30973 |
0.387 |
|
| 2010 |
Konietzko U, Goodger ZV, Meyer M, Kohli BM, Bosset J, Lahiri DK, Nitsch RM. Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiology of Aging. 31: 58-73. PMID 18403052 DOI: 10.1016/J.Neurobiolaging.2008.03.001 |
0.341 |
|
| 2010 |
Ray B, Chauhan NB, Lahiri DK. P4-098: Potential of SAC (S-allyl-L-cysteine), a Component of Garlic, as a Novel Drug Target for Alzheimer's Disease (AD) Based on Studies from Primary Neuronal Cultures and In Vivo Alzheimer's & Dementia. 6: e51-e51. DOI: 10.1016/J.Jalz.2010.08.156 |
0.403 |
|
| 2010 |
Long JM, Lahiri DK. S4-03-03: Novel Specific MicroRNAs in Regulating Neuronal Genes Implicated In Alzheimer's Disease Alzheimer's & Dementia. 6: e13-e13. DOI: 10.1016/J.Jalz.2010.08.042 |
0.581 |
|
| 2010 |
Lahiri DK, Bailey JA, Ray B, Tanila H, Banerjee P, Long J. P3-438: The effect of memantine and rivastigmine on synaptic markers and amyloid processing in cell culture and animal models of Alzheimer's disease Alzheimer's & Dementia. 6: S581-S582. DOI: 10.1016/J.Jalz.2010.05.1980 |
0.588 |
|
| 2009 |
Ray B, Simon JR, Lahiri DK. Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells. Brain Research. 1297: 160-8. PMID 19660442 DOI: 10.1016/J.Brainres.2009.07.096 |
0.302 |
|
| 2009 |
Ray B, Lahiri DK. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Current Opinion in Pharmacology. 9: 434-44. PMID 19656726 DOI: 10.1016/J.Coph.2009.06.012 |
0.448 |
|
| 2009 |
Dosunmu R, Wu J, Adwan L, Maloney B, Basha MR, McPherson CA, Harry GJ, Rice DC, Zawia NH, Lahiri DK. Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. Journal of Alzheimer's Disease : Jad. 18: 211-30. PMID 19584442 DOI: 10.3233/Jad-2009-1138 |
0.439 |
|
| 2009 |
MartÃnez A, Lahiri DK, Giacobini E, Greig NH. Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. Current Alzheimer Research. 6: 83-5. PMID 19355842 DOI: 10.2174/156720509787602924 |
0.379 |
|
| 2009 |
Zawia NH, Lahiri DK, Cardozo-Pelaez F. Epigenetics, oxidative stress, and Alzheimer disease. Free Radical Biology & Medicine. 46: 1241-9. PMID 19245828 DOI: 10.1016/J.Freeradbiomed.2009.02.006 |
0.408 |
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| 2009 |
Schneider LS, Lahiri DK. The perils of Alzheimer's drug development. Current Alzheimer Research. 6: 77-8. PMID 19199878 DOI: 10.2174/156720509787313871 |
0.312 |
|
| 2009 |
Lahiri DK. Celebrating the fifth year anniversary of current Alzheimer research. Current Alzheimer Research. 6: 1-3. PMID 19199869 DOI: 10.2174/156720509787313989 |
0.386 |
|
| 2009 |
Cahill CM, Lahiri DK, Huang X, Rogers JT. Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochimica Et Biophysica Acta. 1790: 615-28. PMID 19166904 DOI: 10.1016/J.Bbagen.2008.12.001 |
0.384 |
|
| 2009 |
Lahiri DK, Maloney B, Ray B, Rogers JT, Zawia N. S4-03-03: The “LEARn” (Latent Early-life Associated Regulation) model may explain the etiology of sporadic cases of Alzheimer's disease Alzheimer's & Dementia. 5: P146-P146. DOI: 10.1016/J.Jalz.2009.05.501 |
0.358 |
|
| 2009 |
Rogers JT, Huang X, Goldstein LE, Moncaster JA, Lahiri DK, Cahill CM, Cho H, Fischer M, Glicksman MA, Cuny GD, Rogers MS, Greig NH, Smith DH, Branden LJ. Specific APP translation blockers as a therapeutic intervention for Alzheimer's disease Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.470 |
0.389 |
|
| 2009 |
Bailey JA, Maloney BJ, Ge Y, Lahiri DK. P2-187: Internalization of the amyloid beta (Aβ) peptide may result in binding to the regulatory region of the APP gene promoter Alzheimer's & Dementia. 5: P315-P316. DOI: 10.1016/J.Jalz.2009.04.499 |
0.367 |
|
| 2008 |
Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochemical Society Transactions. 36: 1282-7. PMID 19021541 DOI: 10.1042/Bst0361282 |
0.371 |
|
| 2008 |
Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology. 9: 375-9. PMID 18668339 DOI: 10.1007/S10522-008-9162-6 |
0.398 |
|
| 2008 |
Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, et al. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 57: 680-90. PMID 18341989 DOI: 10.1016/J.Neuron.2008.02.024 |
0.379 |
|
| 2008 |
Brock B, Basha R, DiPalma K, Anderson A, Harry GJ, Rice DC, Maloney B, Lahiri DK, Zawia NH. Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis. Journal of Alzheimer's Disease : Jad. 13: 71-80. PMID 18334759 DOI: 10.3233/Jad-2008-13108 |
0.394 |
|
| 2008 |
Lahiri DK. 'Current Alzheimer Research': update on lipids, estrogen, neurotrophins and their roles in neurodegeneration. Current Alzheimer Research. 5: 1-3. PMID 18288925 DOI: 10.2174/156720508783884639 |
0.324 |
|
| 2008 |
Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J, Rice DC, Maloney B, Chen D, Lahiri DK, Zawia NH. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3-9. PMID 18171917 DOI: 10.1523/Jneurosci.4405-07.2008 |
0.456 |
|
| 2008 |
Sambamurti K, Prakasam A, Jayachandran AD, Venugopal C, Rao JK, Lahiri DK, Greig NH, Pappolla MA, Zhou Y. P1-412: Isoprenoids phenocopy familial Alzheimer's disease mutations and regulate gamma-secretase Alzheimer's & Dementia. 4: T340-T340. DOI: 10.1016/J.Jalz.2008.05.994 |
0.344 |
|
| 2008 |
Lahiri DK, Maloney B, Basha MR, Chen D, Zawia N. P3-234: Early-life environment affects expression of genes invoved in Alzheimer's disease by an epigenetic mechanism Alzheimer's & Dementia. 4: T589-T589. DOI: 10.1016/J.Jalz.2008.05.1801 |
0.364 |
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| 2008 |
Bailey JA, Lahiri DK. P2-317: Rivastigmine decreases amyloid-β precursor protein and increases synaptic markers in primary neuronal cultures Alzheimer's & Dementia. 4: T465-T465. DOI: 10.1016/J.Jalz.2008.05.1394 |
0.316 |
|
| 2007 |
Bandyopadhyay S, Goldstein LE, Lahiri DK, Rogers JT. Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease. Current Medicinal Chemistry. 14: 2848-64. PMID 18045131 DOI: 10.2174/092986707782360060 |
0.438 |
|
| 2007 |
Maloney B, Ge YW, Alley GM, Lahiri DK. Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease. Journal of Neurochemistry. 103: 1237-57. PMID 17854398 DOI: 10.1111/J.1471-4159.2007.04831.X |
0.425 |
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| 2007 |
Rice SG, Nowak L, Duysen EG, Lockridge O, Lahiri DK, Reyes PF. Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 11: 481-9. PMID 17656828 DOI: 10.3233/Jad-2007-11410 |
0.405 |
|
| 2007 |
Lahiri DK, Alley GM, Tweedie D, Chen D, Greig NH. Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease. Neuromolecular Medicine. 9: 157-68. PMID 17627035 DOI: 10.1007/Bf02685889 |
0.466 |
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| 2007 |
Lahiri DK, Maloney B, Basha MR, Ge YW, Zawia NH. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD. Current Alzheimer Research. 4: 219-28. PMID 17430250 DOI: 10.2174/156720507780362164 |
0.431 |
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| 2007 |
Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, Giordano T, Sambamurti K, Greig NH. The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 386-96. PMID 17003227 DOI: 10.1124/Jpet.106.112102 |
0.452 |
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| 2007 |
Lahiri DK. Alzheimer's disease: Highlights from research on hormones, growth factors and signaling pathways Current Alzheimer Research. 4: 1-2. DOI: 10.2174/156720507779939797 |
0.331 |
|
| 2007 |
Banerjee P, Tanila H, Wisniewski T, Gupta S, LaFerla F, Lahiri DK. P-188: Memantine lowers amyloid beta levels in neuronal cells and transgenic mouse models of Alzheimer's disease Alzheimer's & Dementia. 3: S158-S158. DOI: 10.1016/J.Jalz.2007.04.151 |
0.421 |
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| 2006 |
Bailey JA, Lahiri DK. Neuronal differentiation is accompanied by increased levels of SNAP-25 protein in fetal rat primary cortical neurons: implications in neuronal plasticity and Alzheimer's disease. Annals of the New York Academy of Sciences. 1086: 54-65. PMID 17185505 DOI: 10.1196/Annals.1377.001 |
0.351 |
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| 2006 |
Lahiri DK. Where the actions of environment (nutrition), gene and protein meet: beneficial role of fruit and vegetable juices in potentially delaying the onset of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 10: 359-61; discussion 3. PMID 17183145 DOI: 10.3233/Jad-2006-10402 |
0.418 |
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| 2006 |
Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Current Alzheimer Research. 3: 475-83. PMID 17168646 DOI: 10.2174/156720506779025224 |
0.406 |
|
| 2006 |
Tweedie D, Brossi A, Chen D, Ge YW, Bailey J, Yu QS, Kamal MA, Sambamurti K, Lahiri DK, Greig NH. Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 10: 9-16. PMID 16988475 DOI: 10.3233/Jad-2006-10102 |
0.442 |
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| 2006 |
Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA, Lahiri DK. High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. Journal of Child Neurology. 21: 444-9. PMID 16948926 DOI: 10.1177/08830738060210062201 |
0.37 |
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| 2006 |
Maloney B, Ge YW, Greig NH, Lahiri DK. Characterization of the human β-secretase 2 (BACE2) 5′-flanking region: Identification of a 268-bp region as the basal BACE2 promoter Journal of Molecular Neuroscience. 29: 81-99. PMID 16757812 DOI: 10.1385/Jmn:29:1:81 |
0.368 |
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| 2006 |
Lahiri DK, Maloney B, Ge YW. Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells Journal of Molecular Neuroscience. 29: 65-80. PMID 16757811 DOI: 10.1385/Jmn:29:1:65 |
0.357 |
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| 2006 |
Becaria A, Lahiri DK, Bondy SC, Chen D, Hamadeh A, Li H, Taylor R, Campbell A. Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain. Journal of Neuroimmunology. 176: 16-23. PMID 16697052 DOI: 10.1016/J.Jneuroim.2006.03.025 |
0.328 |
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| 2006 |
Utsuki T, Yu QS, Davidson D, Chen D, Holloway HW, Brossi A, Sambamurti K, Lahiri DK, Greig NH, Giordano T. Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. The Journal of Pharmacology and Experimental Therapeutics. 318: 855-62. PMID 16690718 DOI: 10.1124/Jpet.106.103309 |
0.421 |
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| 2006 |
Lahiri DK, Maloney B, Ge YW. BACE1 gene promoter is differentially regulated: Detection of a novel promoter region for its cell type-specific regulation Journal of Molecular Neuroscience. 28: 193-210. PMID 16679558 DOI: 10.1385/Jmn:28:2:193 |
0.414 |
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| 2006 |
Bolin CM, Basha R, Cox D, Zawia NH, Maloney B, Lahiri DK, Cardozo-Pelaez F. Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 788-90. PMID 16484331 DOI: 10.1096/Fj.05-5091Fje |
0.344 |
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| 2006 |
Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH. A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Current Alzheimer Research. 3: 81-90. PMID 16472208 DOI: 10.2174/156720506775697142 |
0.324 |
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| 2006 |
Bondy SC, Lahiri DK, Perreau VM, Sharman KZ, Campbell A, Zhou J, Sharman EH. Retardation of brain aging by chronic treatment with melatonin. Annals of the New York Academy of Sciences. 1035: 197-215. PMID 15681809 DOI: 10.1196/Annals.1332.013 |
0.389 |
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| 2006 |
Lahiri DK, LaFerla FM. Marking the centennial of Alzheimer's first report of the disease with a perspective of ongoing research and future challenge Current Alzheimer Research. 3: 409-410. DOI: 10.2174/156720506779025260 |
0.379 |
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| 2006 |
Lahiri DK. Editorial- Update on Current Alzheimer Research Current Alzheimer Research. 3: 93-94. DOI: 10.2174/156720506776383040 |
0.326 |
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| 2006 |
Lahiri DK. Editorial - A milestone for current Alzheimer research Current Alzheimer Research. 3: 1. DOI: 10.2174/156720506775697115 |
0.324 |
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| 2006 |
Sobue G, Takahashi M, Yoshida J, Kaibuchi K, Naoe T, Lahiri DK. Integrated molecular medicine for neuronal and neoplastic disorders Annals of the New York Academy of Sciences. 1086: xi-xii. DOI: 10.1196/Annals.1377.015 |
0.359 |
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| 2006 |
Wang R, Maloney B, Lahiri DK. P2-269: ROLE OF THE REPRESSOR ELEMENT 1-SILENCING TRANSCRIPTION FACTOR (REST) IN NEURONAL DIFFERENTIATION AND ITS IMPLICATION IN ALZHEIMER'S DISEASE (AD) Alzheimer's & Dementia. 14: P780-P780. DOI: 10.1016/J.Jalz.2018.06.958 |
0.415 |
|
| 2006 |
Lahiri DK, Chopra N, Maloney B, Greig NH, Chakrabarti S. P3-061: CONSTITUTIVE IN VIVO OVEREXPRESSION OF MIR146A AND MIR200B INDEPENDENTLY MODULATES LEVELS OF ALZHEIMER'S DISEASE (AD)- RELATED PROTEINS IN THE MOUSE HIPPOCAMPUS AND CEREBRAL CORTEX Alzheimer's & Dementia. 14: P1088-P1088. DOI: 10.1016/J.Jalz.2018.06.1417 |
0.426 |
|
| 2006 |
Lecca D, Bader M, Tweedie D, Lahiri DK, Becker RE, Pick C, Greig NH. P3-053: (-)-PHENSERINE (PHEN) AND THE PREVENTION OF PRE-PROGRAMMED CELL DEATH IN ALZHEIMER'S DISEASE (AD) AND MILD TRAUMATIC BRAIN INJURY (MTBI) Alzheimer's & Dementia. 14: P1083-P1083. DOI: 10.1016/J.Jalz.2018.06.1409 |
0.385 |
|
| 2006 |
Lahiri DK, Hickman D, Srinivasan M. P3-050: GLUCOCORTICOID-INDUCED LEUCINE ZIPPER ANALOGS SUPPRESS NEUROINFLAMMATION IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1082-P1082. DOI: 10.1016/J.Jalz.2018.06.1405 |
0.391 |
|
| 2006 |
Bruinsma G, Cullen E, Greig NH, Lahiri D, Sambamurti K, Friedhoff L. P1-004: Oral treatment of mice with Posiphen™
significantly lowers brain levels of beta amyloid (1-42) Alzheimer's & Dementia. 2: S95-S95. DOI: 10.1016/J.Jalz.2006.05.379 |
0.329 |
|
| 2006 |
Lahiri DK, Ge Y, Basha MR, Maloney B, Chen D, Zawia N. S2-01-06: Genetics & epigenetic studies in AD Alzheimer's & Dementia. 2: S24-S24. DOI: 10.1016/J.Jalz.2006.05.079 |
0.348 |
|
| 2006 |
Sokol D, Maloney B, Kardatzke D, Chen D, Lahiri D. [P128]: Role of two Alzheimer's disease protein markers: Amyloid precursor protein and acetylcholinesterase with aggression in autism International Journal of Developmental Neuroscience. 24: 551-551. DOI: 10.1016/J.Ijdevneu.2006.09.190 |
0.416 |
|
| 2005 |
Lahiri DK, Chen DM, Lahiri P, Bondy S, Greig NH. Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases. Annals of the New York Academy of Sciences. 1056: 430-49. PMID 16387707 DOI: 10.1196/Annals.1352.008 |
0.428 |
|
| 2005 |
Lahiri DK. Editorial - Advances of Alzheimer's disease research: Crossroad of basic and translational studies Current Alzheimer Research. 2: 495-496. PMID 16375652 DOI: 10.2174/156720505774932250 |
0.381 |
|
| 2005 |
Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW, Giordano T, Chen D, Furukawa K, Sambamurti K, Brossi A, Lahiri DK. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. 102: 17213-8. PMID 16275899 DOI: 10.1073/Pnas.0508575102 |
0.428 |
|
| 2005 |
Lahiri DK, Ge YW, Maloney B, Wavrant-De Vrièze F, Hardy J. Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease Neurobiology of Aging. 26: 1329-1341. PMID 16243604 DOI: 10.1016/J.Neurobiolaging.2004.11.005 |
0.416 |
|
| 2005 |
Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH. Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2083-4. PMID 16230335 DOI: 10.1096/Fj.05-4375Fje |
0.421 |
|
| 2005 |
Greig NH, Sambamurti K, Yu QS, Brossi A, Bruinsma GB, Lahiri DK. An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current Alzheimer Research. 2: 281-90. PMID 15974893 DOI: 10.2174/1567205054367829 |
0.446 |
|
| 2005 |
Du Y, Chen X, Wei X, Bales KR, Berg DT, Paul SM, Farlow MR, Maloney B, Ge YW, Lahiri DK. NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells. Brain Research. Molecular Brain Research. 136: 177-88. PMID 15893602 DOI: 10.1016/J.Molbrainres.2005.02.001 |
0.36 |
|
| 2005 |
Lahiri DK, Ge YW, Maloney B. Characterization of the APP proximal promoter and 5′-untranslated regions: Identification or cell type-specific domains and implications in APP gene expression and Alzheimer's disease Faseb Journal. 19: 653-655. PMID 15703276 DOI: 10.1096/Fj.04-2900Fje |
0.398 |
|
| 2005 |
Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 823-9. PMID 15673661 DOI: 10.1523/Jneurosci.4335-04.2005 |
0.444 |
|
| 2005 |
Lahiri DK. Editorial - The A's and M's of Alzheimer's disease Current Alzheimer Research. 2: 387. DOI: 10.2174/156720505774330546 |
0.335 |
|
| 2005 |
Lahiri DK. Editorial - Progress of Current Alzheimer Research Current Alzheimer Research. 2: 1-2. DOI: 10.2174/1567205052772696 |
0.334 |
|
| 2004 |
Lahiri DK. Advances in the four major pillars of Alzheimer's disease research: pathobiology, genetics, diagnosis, and treatment Curr Alzheimer Res. 1. PMID 15975062 DOI: 10.2174/1567205043480537 |
0.347 |
|
| 2004 |
Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Annals of the New York Academy of Sciences. 1035: 290-315. PMID 15681814 DOI: 10.1196/Annals.1332.018 |
0.407 |
|
| 2004 |
Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. Annals of the New York Academy of Sciences. 1035: 216-30. PMID 15681810 DOI: 10.1196/Annals.1332.014 |
0.395 |
|
| 2004 |
Kulkarni AP, Kellaway LA, Lahiri DK, Kotwal GJ. Neuroprotection from complement-mediated inflammatory damage. Annals of the New York Academy of Sciences. 1035: 147-64. PMID 15681806 DOI: 10.1196/Annals.1332.010 |
0.31 |
|
| 2004 |
Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT. The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Annals of the New York Academy of Sciences. 1035: 34-48. PMID 15681799 DOI: 10.1196/Annals.1332.003 |
0.365 |
|
| 2004 |
Lahiri DK, Ge YW. Role of the APP promoter in Alzheimer's disease: Cell type-specific expression of the β-amyloid precursor protein Annals of the New York Academy of Sciences. 1030: 310-316. PMID 15659812 DOI: 10.1196/Annals.1329.039 |
0.462 |
|
| 2004 |
Lahiri DK. Functional characterization of amyloid β precursor protein regulatory elements: Rationale for the identification of genetic polymorphism Annals of the New York Academy of Sciences. 1030: 282-288. PMID 15659808 DOI: 10.1196/Annals.1329.035 |
0.448 |
|
| 2004 |
Lahiri DK, Rogers JT, Greig NH, Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Current Pharmaceutical Design. 10: 3111-9. PMID 15544501 DOI: 10.2174/1381612043383331 |
0.446 |
|
| 2004 |
Ge YW, Ghosh C, Song W, Maloney B, Lahiri DK. Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. Journal of Neurochemistry. 90: 1432-44. PMID 15341527 DOI: 10.1111/J.1471-4159.2004.02608.X |
0.43 |
|
| 2004 |
Rogers JT, Lahiri DK. Metal and inflammatory targets for Alzheimer's disease. Current Drug Targets. 5: 535-51. PMID 15270200 DOI: 10.2174/1389450043345272 |
0.444 |
|
| 2004 |
Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Current Drug Targets. 5: 517-28. PMID 15270198 DOI: 10.2174/1389450043345335 |
0.461 |
|
| 2004 |
Maloney B, Ge YW, Greig N, Lahiri DK. Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: Implications in Alzheimer's disease Faseb Journal. 18: 1288-1290. PMID 15208260 DOI: 10.1096/Fj.03-1703Fje |
0.441 |
|
| 2004 |
Lahiri DK. Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene Journal of Molecular Neuroscience : Mn. 23: 225-233. PMID 15181251 DOI: 10.1385/Jmn:23:3:225 |
0.442 |
|
| 2004 |
Lahiri DK, Sambamurti K, Bennett DA. Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. Neurobiology of Aging. 25: 651-60. PMID 15172744 DOI: 10.1016/J.Neurobiolaging.2003.12.024 |
0.439 |
|
| 2004 |
Lahiri DK, Greig NH. Lethal weapon: Amyloid β-peptide, role in the oxidative stress and neurodegeneration of Alzheimer's disease Neurobiology of Aging. 25: 581-587. PMID 15172733 DOI: 10.1016/J.Neurobiolaging.2004.02.002 |
0.338 |
|
| 2004 |
Evans RM, Hui S, Perkins A, Lahiri DK, Poirier J, Farlow MR. Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology. 62: 1869-71. PMID 15159498 DOI: 10.1212/01.Wnl.0000125323.15458.3F |
0.384 |
|
| 2004 |
Lahiri DK, Chen D, Ge YW, Bondy SC, Sharman EH. Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex. Journal of Pineal Research. 36: 224-31. PMID 15066046 DOI: 10.1111/J.1600-079X.2004.00121.X |
0.385 |
|
| 2004 |
Ge YW, Maloney B, Sambamurti K, Lahiri DK. Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1037-9. PMID 15059977 DOI: 10.1096/Fj.03-1379Fje |
0.357 |
|
| 2004 |
Sambamurti K, Kinsey R, Maloney B, Ge YW, Lahiri DK. Gene structure and organization of the human beta-secretase (BACE) promoter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1034-6. PMID 15059975 DOI: 10.1096/Fj.03-1378Fje |
0.387 |
|
| 2004 |
Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J. Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. The Journal of Biological Chemistry. 279: 20378-86. PMID 14985339 DOI: 10.1074/Jbc.M400805200 |
0.432 |
|
| 2004 |
Campbell A, Becaria A, Lahiri DK, Sharman K, Bondy SC. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. Journal of Neuroscience Research. 75: 565-72. PMID 14743440 DOI: 10.1002/Jnr.10877 |
0.346 |
|
| 2004 |
Lahiri DK. Alzheimer's disease - Current trends in basic and clinical research. Highlights from the 16th ECNP Expert Opinion On Investigational Drugs. 13: 79-86. PMID 14680456 DOI: 10.1517/13543784.13.1.79 |
0.345 |
|
| 2004 |
Lahiri D. Preface: Developments in Understanding of Alzheimer Disease Current Alzheimer Research. 1: ii-ii. DOI: 10.2174/15672050104010400Ii |
0.393 |
|
| 2004 |
Lahiri D. Preface [Hot Topic: Advances in the Four Pillars of Alzheimer Disease Research: Pathobiology, Genetics, Diagnosis, and Treatment (Debomoy K. Lahiri)] Current Alzheimer Research. 1: ii-ii. DOI: 10.2174/15672050104010300Ii |
0.309 |
|
| 2004 |
Lahiri D. Preface: Scope of Current Alzheimer Research Debomoy Current Alzheimer Research. 1: ii-ii. DOI: 10.2174/15672050104010200Ii |
0.324 |
|
| 2004 |
Lahiri D. Preface: Highlights of Recent Progress in Alzheimers Disease Research [ Hot Topics in Alzheimers Disease Research (Guest Editor: Debomoy K. Lahiri)] Current Drug Targets. 5: ii-ii. DOI: 10.2174/13894501104050600Ii |
0.36 |
|
| 2004 |
Greig NH, Utsuki T, Wang Y, Ingram DK, Mamczar J, Rogers J, Yun Q, Holloway HW, Perry TA, Sambamurti K, Scali C, Pepeu G, Lahiri DK. P1-414 Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers amyloid-beta peptide in rodents: a new treatment strategy for Alzheimer's disease Neurobiology of Aging. 25: S216. DOI: 10.1016/S0197-4580(04)80726-7 |
0.396 |
|
| 2004 |
Lahiri DK, Bailey J, Alley G, Chen D, Sambamurti K, Greig N. O3-06-01 Effects of diverse cholinesterase inhibitors and memantine on the amyloid pathway and its implications in Alzheimer's disease Neurobiology of Aging. 25: S63-S64. DOI: 10.1016/S0197-4580(04)80214-8 |
0.395 |
|
| 2003 |
Lahiri DK, Ghosh C, Ge YW. A Proximal Gene Promoter Region for the β-Amyloid Precursor Protein Provides a Link between Development, Apoptosis, and Alzheimer's Disease Annals of the New York Academy of Sciences. 1010: 643-647. PMID 15033805 DOI: 10.1196/Annals.1299.118 |
0.402 |
|
| 2003 |
Lahiri DK, Chen D, Ge YW, Farlow M, Kotwal G, Kanthasamy A, Ingram DK, Greig NH. Does nitric oxide synthase contribute to the pathogenesis of Alzheimer's disease?: effects of beta-amyloid deposition on NOS in transgenic mouse brain with AD pathology. Annals of the New York Academy of Sciences. 1010: 639-42. PMID 15033804 DOI: 10.1196/annals.1299.117 |
0.307 |
|
| 2003 |
Lahiri DK, Farlow MR. Review: cholinesterase inhibitors have a modest effect on neuropsychiatric and functional outcomes in Alzheimer's disease. Evidence-Based Mental Health. 6: 94. PMID 12893805 DOI: 10.1136/Ebmh.6.3.94 |
0.347 |
|
| 2003 |
Lahiri DK. 6th International Conference on Alzheimer's Disease and Parkinson's Disease Expert Opinion On Investigational Drugs. 12: 1433-1440. PMID 12882629 DOI: 10.1517/13543784.12.8.1433 |
0.352 |
|
| 2003 |
Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K. APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 502-9. PMID 12763021 DOI: 10.1016/S0006-291X(03)00797-6 |
0.414 |
|
| 2003 |
Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. Journal of Neuroscience Research. 72: 603-12. PMID 12749025 DOI: 10.1002/Jnr.10611 |
0.377 |
|
| 2003 |
Lahiri DK, Chen D, Vivien D, Ge YW, Greig NH, Rogers JT. Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 5: 81-90. PMID 12719626 DOI: 10.3233/Jad-2003-5203 |
0.406 |
|
| 2003 |
Lesné S, Docagne F, Gabriel C, Liot G, Lahiri DK, Buée L, Plawinski L, Delacourte A, MacKenzie ET, Buisson A, Vivien D. Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. The Journal of Biological Chemistry. 278: 18408-18. PMID 12626500 DOI: 10.1074/Jbc.M300819200 |
0.358 |
|
| 2003 |
Lahiri DK, Farlow MR, Sambamurti K, Greig NH, Giacobini E, Schneider LS. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Current Drug Targets. 4: 97-112. PMID 12558063 DOI: 10.2174/1389450033346957 |
0.468 |
|
| 2003 |
Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K. Addendum “APH1, PEN2, and Nicastrin increase Aβ levels and γ-secretase activity” [Biochem. Biophys. Res. Commun. 305 (2003) 502–509] Biochemical and Biophysical Research Communications. 307: 756. DOI: 10.1016/S0006-291X(03)01247-6 |
0.304 |
|
| 2002 |
Greig NH, Lahiri DK, Sambamurti K. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. International Psychogeriatrics / Ipa. 14: 77-91. PMID 12636181 DOI: 10.1017/S1041610203008676 |
0.429 |
|
| 2002 |
Ge YW, Lahiri DK. Regulation of promoter activity of the APP gene by cytokines and growth factors: Implications in Alzheimer's disease Annals of the New York Academy of Sciences. 973: 463-467. PMID 12485912 DOI: 10.1111/J.1749-6632.2002.Tb04684.X |
0.392 |
|
| 2002 |
Lahiri DK, Alley GM, Ge YW, Du Y. Functional characterization of the 5′-regulatory region of the murine apolipoprotein gene Annals of the New York Academy of Sciences. 973: 340-344. PMID 12485890 DOI: 10.1111/J.1749-6632.2002.Tb04662.X |
0.355 |
|
| 2002 |
Lahiri DK, Kotwal GJ, Farlow MR, Sima A, Kupsky W, Sarkar FH, Sambamurti K. The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease. Annals of the New York Academy of Sciences. 973: 334-9. PMID 12485889 DOI: 10.1111/J.1749-6632.2002.Tb04661.X |
0.447 |
|
| 2002 |
Kotwal GJ, Lahiri DK, Hicks R. Potential intervention by vaccinia virus complement control protein of the signals contributing to the progression of central nervous system injury to Alzheimer's disease Annals of the New York Academy of Sciences. 973: 317-322. PMID 12485887 DOI: 10.1111/J.1749-6632.2002.Tb04659.X |
0.418 |
|
| 2002 |
Utsuki T, Shoaib M, Holloway HW, Ingram DK, Wallace WC, Haroutunian V, Sambamurti K, Lahiri DK, Greig NH. Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat. Journal of Alzheimer's Disease : Jad. 4: 405-15. PMID 12446972 DOI: 10.3233/Jad-2002-4507 |
0.365 |
|
| 2002 |
Zhu X, Yu QS, Cutler RG, Culmsee CW, Holloway HW, Lahiri DK, Mattson MP, Greig NH. Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives. Journal of Medicinal Chemistry. 45: 5090-7. PMID 12408720 DOI: 10.1021/Jm020044D |
0.33 |
|
| 2002 |
Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, et al. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. Journal of Molecular Neuroscience : Mn. 19: 77-82. PMID 12212798 DOI: 10.1007/S12031-002-0014-6 |
0.386 |
|
| 2002 |
Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, et al. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. The Journal of Biological Chemistry. 277: 45518-28. PMID 12198135 DOI: 10.1074/Jbc.M207435200 |
0.322 |
|
| 2002 |
Lahiri DK, Utsuki T, Chen D, Farlow MR, Shoaib M, Ingram DK, Greig NH. Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins. Annals of the New York Academy of Sciences. 965: 364-72. PMID 12105112 DOI: 10.1111/J.1749-6632.2002.Tb04178.X |
0.374 |
|
| 2002 |
Lahiri DK, Nall C, Chen D, Zaphiriou M, Morgan C, Nurnberger JI. Developmental expression of the beta-amyloid precursor protein and heat-shock protein 70 in the cerebral hemisphere region of the rat brain. Annals of the New York Academy of Sciences. 965: 324-33. PMID 12105108 DOI: 10.1111/J.1749-6632.2002.Tb04174.X |
0.383 |
|
| 2002 |
Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Medicine. 1: 1-31. PMID 12025813 DOI: 10.1385/Nmm:1:1:1 |
0.453 |
|
| 2002 |
Greig NH, Utsuki T, Yu Q, Zhu X, Holloway HW, Perry T, Lee B, Ingram DK, Lahiri DK. A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Current Medical Research and Opinion. 17: 159-65. PMID 11900310 DOI: 10.1185/0300799039117057 |
0.408 |
|
| 2002 |
Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH. A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. The Journal of Pharmacology and Experimental Therapeutics. 300: 958-66. PMID 11861804 DOI: 10.1124/Jpet.300.3.958 |
0.321 |
|
| 2002 |
Lahiri DK, Farlow MR, Greig NH, Sambamurti K. Current drug targets for Alzheimer's disease treatment Drug Development Research. 56: 267-281. DOI: 10.1002/Ddr.10081 |
0.478 |
|
| 2002 |
Sambamurti K, Hardy J, Refolo LM, Lahiri DK. Targeting APP metabolism for the treatment of Alzheimer's disease Drug Development Research. 56: 211-227. DOI: 10.1002/Ddr.10077 |
0.468 |
|
| 2001 |
Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proceedings of the National Academy of Sciences of the United States of America. 98: 7605-10. PMID 11404470 DOI: 10.1073/Pnas.131152998 |
0.408 |
|
| 2000 |
Lahiri DK, Farlow MR, Hintz N, Utsuki T, Greig NH. Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease. Acta Neurologica Scandinavica. Supplementum. 176: 60-7. PMID 11273593 DOI: 10.1034/J.1600-0404.2000.00309.X |
0.465 |
|
| 2000 |
Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Perry TA, Brossi A, Ingram DK, Deutsch J, Lahiri DK, Soncrant TT. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta Neurologica Scandinavica. Supplementum. 176: 74-84. PMID 11261809 DOI: 10.1034/J.1600-0404.2000.00311.X |
0.328 |
|
| 2000 |
Lahiri DK, Song W, Ge YW. Analysis of the 5'-flanking region of the β-amyloid precursor protein gene that contributes to increased promoter activity in differentiated neuronal cells Molecular Brain Research. 77: 185-198. PMID 10837914 DOI: 10.1016/S0169-328X(00)00051-6 |
0.342 |
|
| 2000 |
Lahiri DK, Ge YW, Farlow MR. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Annals of the New York Academy of Sciences. 903: 387-93. PMID 10818529 DOI: 10.1111/J.1749-6632.2000.Tb06390.X |
0.334 |
|
| 2000 |
Lahiri DK, Xu Y, Klaunig J, Baiyewu O, Ogunniyi A, Hall K, Hendrie H, Sahota A. Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population. Annals of the New York Academy of Sciences. 893: 331-6. PMID 10672260 DOI: 10.1111/J.1749-6632.1999.Tb07848.X |
0.379 |
|
| 2000 |
Lahiri DK, Glasky MS, Farlow MR. Increased secretion of the β-amyloid precursor protein in PC12 cells treated with a memory-enhancing drug AIT-082 Neurobiology of Aging. 21: 274. DOI: 10.1016/S0197-4580(00)83184-X |
0.303 |
|
| 2000 |
Greig NH, Yu Q, Utsuki T, Halloway HW, Ingram DK, Haroutinian V, Sambamurti K, Lahiri DK. Novel selective butyrylcholinesterase inhibitors as a new strategy for the treatment of Alzheimer's disease Neurobiology of Aging. 21: 274. DOI: 10.1016/S0197-4580(00)83183-8 |
0.353 |
|
| 2000 |
Kotwal GJ, Lahiri DK. Regulation of Aβ-mediated complement activation by vaccinia virus complement control protein Neurobiology of Aging. 21: 128. DOI: 10.1016/S0197-4580(00)82375-1 |
0.313 |
|
| 1999 |
Ghosh C, Lahiri DK. Increased vulnerability of neuronal cell lines to sodium nitroprusside- mediated toxicity is caused by the decreased level of nitric oxide metabolites Journal of Molecular Neuroscience. 13: 77-92. PMID 10691295 DOI: 10.1385/Jmn:13:1-2:77 |
0.306 |
|
| 1999 |
Farlow MR, Cyrus PA, Nadel A, Lahiri DK, Brashear A, Gulanski B. Metrifonate treatment of AD: influence of APOE genotype. Neurology. 53: 2010-6. PMID 10599773 DOI: 10.1212/Wnl.53.9.2010 |
0.358 |
|
| 1999 |
Daly J, Lahiri DK, Kotwal GJ. Examination of the interactions of the amyloid precursor protein carboxyl terminus to intracellular protein: Possible role in apoptosis Progress in Neuro-Psychopharmacology and Biological Psychiatry. 23: 861-875. PMID 10509380 DOI: 10.1016/S0278-5846(99)00046-9 |
0.408 |
|
| 1999 |
Lahiri DK, Nall C, Ge YW. Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element Molecular Brain Research. 71: 32-41. PMID 10407184 DOI: 10.1016/S0169-328X(99)00150-3 |
0.391 |
|
| 1999 |
Lahiri DK. Melatonin affects the metabolism of the β-amyloid precursor protein in different cell types Journal of Pineal Research. 26: 137-146. PMID 10231726 DOI: 10.1111/J.1600-079X.1999.Tb00575.X |
0.41 |
|
| 1998 |
Song W, Lahiri DK. Isolation of the genomic clone of the rhesus monkey beta-amyloid precursor protein Biochemistry and Molecular Biology International. 46: 755-764. PMID 9844737 DOI: 10.1080/15216549800204302 |
0.327 |
|
| 1998 |
Song W, Lahiri DK. Molecular cloning of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein: Structural characterization and a comparative study with other species Gene. 217: 151-164. PMID 9841227 DOI: 10.1016/S0378-1119(98)00337-0 |
0.331 |
|
| 1998 |
Daly J, Lahiri DK, Justus DE, Kotwal GJ. Detection of the membrane-retained carboxy-terminal tail containing polypeptides of the amyloid precursor protein in tissue from Alzheimer's disease brain. Life Sciences. 63: 2121-31. PMID 9839536 DOI: 10.1016/S0024-3205(99)80009-5 |
0.432 |
|
| 1998 |
Lahiri DK, Farlow MR, Sambamurti K. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Research. Molecular Brain Research. 62: 131-40. PMID 9813282 DOI: 10.1016/S0169-328X(98)00236-8 |
0.431 |
|
| 1998 |
Song W, Lahiri DK. Functional identification of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein Gene. 217: 165-176. PMID 9795200 DOI: 10.1016/S0378-1119(98)00340-0 |
0.303 |
|
| 1998 |
Sambamurti K, Lahiri DK. ERAB contains a putative noncleavable signal peptide Biochemical and Biophysical Research Communications. 249: 546-549. PMID 9712734 DOI: 10.1006/Bbrc.1998.9178 |
0.397 |
|
| 1998 |
Lahiri DK. An region upstream of the gene promoter for the β-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells Molecular Brain Research. 58: 112-122. PMID 9685602 DOI: 10.1016/S0169-328X(98)00115-6 |
0.394 |
|
| 1998 |
Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL. Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology. 50: 669-77. PMID 9521254 DOI: 10.1212/Wnl.50.3.669 |
0.368 |
|
| 1997 |
Song W, Lahiri DK. Melatonin alters the metabolism of the β-amyloid precursor protein in the neuroendocrine cell line PC12 Journal of Molecular Neuroscience. 9: 75-92. PMID 9407389 DOI: 10.1007/Bf02736852 |
0.393 |
|
| 1997 |
Lahiri DK, Farlow MR, Sambamurti K, Nall C. The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells. Life Sciences. 61: 1985-92. PMID 9366505 DOI: 10.1016/S0024-3205(97)00868-0 |
0.395 |
|
| 1997 |
Lahiri DK, Farlow MR, Nurnberger JI, Greig NH. Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures. Annals of the New York Academy of Sciences. 826: 416-21. PMID 9329715 DOI: 10.1111/J.1749-6632.1997.Tb48495.X |
0.374 |
|
| 1996 |
Farlow MR, Lahiri DK, Poirier J, Davignon J, Hui S. Apolipoprotein E genotype and gender influence response to tacrine therapy. Annals of the New York Academy of Sciences. 802: 101-10. PMID 8993489 DOI: 10.1111/J.1749-6632.1996.Tb32603.X |
0.344 |
|
| 1996 |
Lahiri DK, Farlow MR. Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines. Journal of Molecular Neuroscience : Mn. 7: 41-9. PMID 8835781 DOI: 10.1007/Bf02736847 |
0.353 |
|
| 1996 |
Lahiri D, Nall C, Zaphiriou M, Nurnberger J, Nurnberger J. Expression of beta-amyloid precursor protein in the developing rat brain Biological Psychiatry. 39: 589. DOI: 10.1016/0006-3223(96)84249-1 |
0.357 |
|
| 1995 |
Hendrie HC, Hall KS, Hui S, Unverzagt FW, Yu CE, Lahiri DK, Sahota A, Farlow M, Musick B, Class CA. Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans. Annals of Neurology. 37: 118-20. PMID 7818244 DOI: 10.1002/Ana.410370123 |
0.371 |
|
| 1995 |
Lahiri DK, Nall C. Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1 Molecular Brain Research. 32: 233-240. PMID 7500834 DOI: 10.1016/0169-328X(95)00078-7 |
0.313 |
|
| 1994 |
Lahiri DK, Lewis S, Farlow MR. Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines. Journal of Neuroscience Research. 37: 777-87. PMID 8046778 DOI: 10.1002/Jnr.490370612 |
0.422 |
|
| 1994 |
Lahiri DK. Reversibility of the effect of tacrine on the secretion of the β-amyloid precursor protein in cultured cells Neuroscience Letters. 181: 149-152. PMID 7898757 DOI: 10.1016/0304-3940(94)90581-9 |
0.401 |
|
| 1994 |
Lahiri DK. Effect of ionophores on the processing of the beta-amyloid precursor protein in different cell lines. Cellular and Molecular Neurobiology. 14: 297-313. PMID 7788640 DOI: 10.1007/Bf02088713 |
0.341 |
|
| 1988 |
Lafauci G, Lahiri D, Refolo L, Wallace W, Anderson J, Mehta P, Robakis NK. STRUCTURAL AND EXPRESSION STUDIES OF THE ALZHEIMER AMYLOID PRECURSOR Alzheimer Disease & Associated Disorders. 2: 279. DOI: 10.1097/00002093-198802030-00128 |
0.395 |
|
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