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Lee Limbird - Publications

Affiliations: 
1979- Pharmacology Vanderbilt University, Nashville, TN 
Website:
https://medschool.vanderbilt.edu/pharmacology/person/lee-limbird

158 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Feldman RD, Ding Q, Hussain Y, Limbird LE, Pickering JG, Gros R. Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26911792 DOI: 10.1096/fj.15-275552  1
2011 Limbird LE. Historical perspective for understanding of adrenergic receptors. Current Topics in Membranes. 67: 1-17. PMID 21771483 DOI: 10.1016/B978-0-12-384921-2.00001-X  1
2011 Brady AE, Chen Y, Limbird LE, Wang Q. Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 746: 347-55. PMID 21607867 DOI: 10.1007/978-1-61779-126-0_19  1
2010 Lu R, Chen Y, Cottingham C, Peng N, Jiao K, Limbird LE, Wyss JM, Wang Q. Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor. Molecular Pharmacology. 78: 279-86. PMID 20430865 DOI: 10.1124/mol.110.065300  1
2009 Ding Q, Gros R, Limbird LE, Chorazyczewski J, Feldman RD. Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. American Journal of Physiology. Cell Physiology. 297: C1178-87. PMID 19741198 DOI: 10.1152/ajpcell.00185.2009  1
2009 Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. The Journal of Biological Chemistry. 284: 13233-43. PMID 19276088 DOI: 10.1074/jbc.M807535200  1
2009 Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. The Journal of Biological Chemistry. 284: 5742-52. PMID 19106094 DOI: 10.1074/jbc.M808507200  1
2009 Nag S, Wang Q, Limbird LE, Mokha SS. Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behavioural Brain Research. 197: 457-61. PMID 18957308 DOI: 10.1016/j.bbr.2008.09.036  1
2008 Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown NJ. Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes. Academic Medicine : Journal of the Association of American Medical Colleges. 83: 969-75. PMID 18820531 DOI: 10.1097/ACM.0b013e3181850950  1
2007 Wang Q, Limbird LE. Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochemical Pharmacology. 73: 1135-45. PMID 17229402 DOI: 10.1016/j.bcp.2006.12.024  1
2006 Gros R, Ding Q, Chorazyczewski J, Pickering JG, Limbird LE, Feldman RD. Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization. Circulation Research. 99: 845-52. PMID 16973907 DOI: 10.1161/01.RES.0000245189.21703.c0  1
2006 Wang Q, Lu R, Zhao J, Limbird LE. Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation. The Journal of Biological Chemistry. 281: 25948-55. PMID 16809338 DOI: 10.1074/jbc.M605415200  1
2005 Hu X, Friedman D, Hill S, Caprioli R, Nicholson W, Powers AC, Hunter L, Limbird LE. Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of Molecular Endocrinology. 35: 73-88. PMID 16087723 DOI: 10.1677/jme.1.01764  1
2005 Limbird LE. Cell surface receptors: A short course on theory and methods: Third edition Cell Surface Receptors: a Short Course On Theory and Methods: Third Edition. 1-219. DOI: 10.1007-0-387-23080-7  1
2004 Limbird LE. The receptor concept: a continuing evolution. Molecular Interventions. 4: 326-36. PMID 15616162 DOI: 10.1124/mi.4.6.6  1
2004 Zhang YQ, Limbird LE. Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles. Biochemical Society Transactions. 32: 856-60. PMID 15494033 DOI: 10.1042/BST0320856  1
2004 Nickols HH, Shah VN, Chazin WJ, Limbird LE. Calmodulin interacts with the V2 vasopressin receptor: elimination of binding to the C terminus also eliminates arginine vasopressin-stimulated elevation of intracellular calcium. The Journal of Biological Chemistry. 279: 46969-80. PMID 15319442 DOI: 10.1074/jbc.M407351200  1
2004 Brady AE, Wang Q, Limbird LE. Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology (Clifton, N.J.). 259: 371-8. PMID 15250505 DOI: 10.1385/1-59259-754-8:371  1
2004 Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (New York, N.Y.). 304: 1940-4. PMID 15218143 DOI: 10.1126/science.1098274  1
2004 Tan CM, Brady AE, Nickols HH, Wang Q, Limbird LE. Membrane trafficking of G protein-coupled receptors. Annual Review of Pharmacology and Toxicology. 44: 559-609. PMID 14744258 DOI: 10.1146/annurev.pharmtox.44.101802.121558  1
2004 Limbird LE. α2-Adrenergic Receptors Primer On the Autonomic Nervous System: Second Edition. 54-56. DOI: 10.1016/B978-012589762-4/50013-X  1
2003 Tan CM, Nickols HH, Limbird LE. Appropriate polarization following pharmacological rescue of V2 vasopressin receptors encoded by X-linked nephrogenic diabetes insipidus alleles involves a conformation of the receptor that also attains mature glycosylation. The Journal of Biological Chemistry. 278: 35678-86. PMID 12824183 DOI: 10.1074/jbc.M301888200  1
2003 Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. The Journal of Biological Chemistry. 278: 32405-12. PMID 12738775 DOI: 10.1074/jbc.M304195200  1
2002 Wang Q, Limbird LE. Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3. The Journal of Biological Chemistry. 277: 50589-96. PMID 12376539 DOI: 10.1074/jbc.M208503200  1
2002 Franowicz JS, Kessler LE, Borja CM, Kobilka BK, Limbird LE, Arnsten AF. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8771-7. PMID 12351753  1
2002 Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE. Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proceedings of the National Academy of Sciences of the United States of America. 99: 12471-6. PMID 12205290 DOI: 10.1073/pnas.122368499  1
2002 Brady AE, Limbird LE. G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. Cellular Signalling. 14: 297-309. PMID 11858937 DOI: 10.1016/S0898-6568(01)00239-X  1
2002 Wozniak M, Saunders C, Schramm N, Keefer JR, Limbird LE. Morphological and biochemical strategies for monitoring trafficking of epitope-tagged G protein-coupled receptors in agonist-naive and agonist-occupied states. Methods in Enzymology. 343: 530-44. PMID 11665590 DOI: 10.1016/S0076-6879(02)43156-4  1
2002 Tan CM, Limbird LE. Receptors in disease: A focus on G protein-coupled receptors Pharmaceutical News. 9: 327-336. DOI: 10.1080/10718940216620  1
2001 Schramm NL, McDonald MP, Limbird LE. The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4875-82. PMID 11425914  1
2001 Wilson MH, Highfield HA, Limbird LE. The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnover. Molecular Pharmacology. 59: 929-38. PMID 11259639  1
2001 Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. The Journal of Biological Chemistry. 276: 15003-8. PMID 11154706 DOI: 10.1074/jbc.M011679200  1
2000 Edwards SW, Tan CM, Limbird LE. Localization of G-protein-coupled receptors in health and disease. Trends in Pharmacological Sciences. 21: 304-8. PMID 10918636 DOI: 10.1016/S0165-6147(00)01513-3  1
2000 Kingery WS, Guo TZ, Davies MF, Limbird L, Maze M. The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain. 85: 345-58. PMID 10781908 DOI: 10.1016/S0304-3959(99)00286-9  1
2000 Holmes EW, Burks TF, Dzau V, Hindery MA, Jones RF, Kaye CI, Korn D, Limbird LE, Marchase RB, Perlmutter R, Sanfilippo F, Strom BL. Measuring contributions to the research mission of medical schools. Academic Medicine : Journal of the Association of American Medical Colleges. 75: 303-13. PMID 10724325  1
2000 Wilson MH, Limbird LE. Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor. Biochemistry. 39: 693-700. PMID 10651634 DOI: 10.1021/bi9920275  1
2000 Saunders C, Limbird LE. Microtubule-dependent regulation of alpha(2B) adrenergic receptors in polarized MDCKII cells requires the third intracellular loop but not G protein coupling. Molecular Pharmacology. 57: 44-52. PMID 10617677  1
1999 Saunders C, Limbird LE. Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues. Pharmacology & Therapeutics. 84: 193-205. PMID 10596906 DOI: 10.1016/S0163-7258(99)00032-7  1
1999 Schramm NL, Limbird LE. Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. The Journal of Biological Chemistry. 274: 24935-40. PMID 10455169 DOI: 10.1074/jbc.274.35.24935  1
1999 Hein L, Limbird LE, Eglen RM, Kobilka BK. Gene substitution/knockout to delineate the role of alpha 2-adrenoceptor subtypes in mediating central effects of catecholamines and imidazolines. Annals of the New York Academy of Sciences. 881: 265-71. PMID 10415924 DOI: 10.1111/j.1749-6632.1999.tb09368.x  1
1999 Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Molecular Pharmacology. 56: 154-61. PMID 10385696  1
1999 Limbird LE, Vaughan DE. Augmenting beta receptors in the heart: short-term gains offset by long-term pains? Proceedings of the National Academy of Sciences of the United States of America. 96: 7125-7. PMID 10377378 DOI: 10.1073/pnas.96.13.7125  1
1999 Edwards SW, Limbird LE. Role for the third intracellular loop in cell surface stabilization of the alpha2A-adrenergic receptor. The Journal of Biological Chemistry. 274: 16331-6. PMID 10347190 DOI: 10.1074/jbc.274.23.16331  1
1999 Prezeau L, Richman JG, Edwards SW, Limbird LE. The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. The Journal of Biological Chemistry. 274: 13462-9. PMID 10224112 DOI: 10.1074/jbc.274.19.13462  1
1999 Guo TZ, Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M. Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. Anesthesiology. 90: 470-6. PMID 9952154 DOI: 10.1097/00000542-199902000-00022  1
1998 Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George AL, McNamara JO. Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. Neurology. 51: 1730-1. PMID 9855534  1
1998 MacMillan LB, Lakhlani P, Lovinger D, Limbird LE. Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings. Recent Progress in Hormone Research. 53: 25-42. PMID 9769701  1
1998 Saunders C, Keefer JR, Bonner CA, Limbird LE. Targeting of G protein-coupled receptors to the basolateral surface of polarized renal epithelial cells involves multiple, non-contiguous structural signals. The Journal of Biological Chemistry. 273: 24196-206. PMID 9727043 DOI: 10.1074/jbc.273.37.24196  1
1998 Limbird LE, Taylor P. Endocrine disruptors signal the need for receptor models and mechanisms to inform policy. Cell. 93: 157-63. PMID 9568709 DOI: 10.1016/S0092-8674(00)81568-8  1
1998 Wozniak M, Limbird LE. Trafficking itineraries of G protein-coupled receptors in epithelial cells do not predict receptor localization in neurons. Brain Research. 780: 311-22. PMID 9507174 DOI: 10.1016/S0006-8993(97)01216-X  1
1998 Janumpalli S, Butler LS, MacMillan LB, Limbird LE, McNamara JO. A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2004-8. PMID 9482787  1
1998 MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. Advances in Pharmacology (San Diego, Calif.). 42: 493-6. PMID 9327947  1
1998 Scriabine A, Gordis E, Silva AJ, Federoff HJ, Limbird LE. Application of gene knockout technique to alcohol research. Satellite symposium to the 28(th) annual meeting of the society for neuroscience. Los Angeles, CA, November 7, 1998 Cns Drug Reviews. 4: 398-400.  1
1997 Wang RX, Limbird LE. Distribution of mRNA encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2A subtype in apoptosis. Molecular Pharmacology. 52: 1071-80. PMID 9415717  1
1997 Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL. The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7157-65. PMID 9278550  1
1997 Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proceedings of the National Academy of Sciences of the United States of America. 94: 9950-5. PMID 9275232 DOI: 10.1073/pnas.94.18.9950  1
1997 Saunders C, Limbird LE. Disruption of microtubules reveals two independent apical targeting mechanisms for G-protein-coupled receptors in polarized renal epithelial cells. The Journal of Biological Chemistry. 272: 19035-45. PMID 9228087 DOI: 10.1074/jbc.272.30.19035  1
1997 Wozniak M, Keefer JR, Saunders C, Limbird LE. Differential targeting and retention of G protein-coupled receptors in polarized epithelial cells. Journal of Receptor and Signal Transduction Research. 17: 373-83. PMID 9029502 DOI: 10.3109/10799899709036615  1
1997 MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. In Vivo Mutation of the α2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes Advances in Pharmacology. 42: 493-496. DOI: 10.1016/S1054-3589(08)60796-6  1
1996 Wang R, Macmillan LB, Fremeau RT, Magnuson MA, Lindner J, Limbird LE. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience. 74: 199-218. PMID 8843087  1
1996 Lakhlani PP, Lovinger DM, Limbird LE. Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling. Molecular Pharmacology. 50: 96-103. PMID 8700125  1
1996 MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE. Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science (New York, N.Y.). 273: 801-3. PMID 8670421  1
1996 Wozniak M, Limbird LE. The three alpha 2-adrenergic receptor subtypes achieve basolateral localization in Madin-Darby canine kidney II cells via different targeting mechanisms. The Journal of Biological Chemistry. 271: 5017-24. PMID 8617778 DOI: 10.1074/jbc.271.9.5017  1
1996 Lanier SM, Lafontan M, Limbird LE, Paris H. Summary of the ASPET-sponsored Colloquium: Alpha-2 adrenergic receptors: structure, function, and therapeutic implications, October 25-27, 1995. The Journal of Pharmacology and Experimental Therapeutics. 277: 10-6. PMID 8613905  1
1996 Saunders C, Keefer JR, Kennedy AP, Wells JN, Limbird LE. Receptors coupled to pertussis toxin-sensitive G-proteins traffic to opposite surfaces in Madin-Darby canine kidney cells. A1 adenosine receptors achieve apical and alpha 2A adrenergic receptors achieve basolateral localization. The Journal of Biological Chemistry. 271: 995-1002. PMID 8557716  1
1996 Piascik MT, Smith MS, Edelmann SE, MacMilan LB, Limbird LE. α2 and α1, -adrenergic receptors in regulation of peripheral vascular function Faseb Journal. 10: A426.  1
1996 Saunders C, Keefer JR, Limbird LE. Receptor chimeras and truncations reveal α2a adrenergic receptor (a2aar) domains involved in its basolateral localization in mdckii cells Faseb Journal. 10: A419.  1
1995 Limbird LE, MacMillan LB, Keefer JR. Specificity in α2-adrenoceptor signal transduction: Receptor subtypes, coupling to distinct signal transduction pathways and localization to discrete subdomains in target cells Pharmacology Communications. 6: 139-145.  1
1995 Uhlen S, Axelrod D, Keefer JR, Limbird LE, Neubig RR. Membrane organization and mobility of α2 adrenergic receptors in MDCK cells Pharmacology Communications. 6: 155-167.  1
1994 Keefer JR, Kennedy ME, Limbird LE. Unique structural features important for stabilization versus polarization of the alpha 2A-adrenergic receptor on the basolateral membrane of Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 269: 16425-32. PMID 8206950  1
1994 Kennedy ME, Limbird LE. Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation. The Journal of Biological Chemistry. 269: 31915-22. PMID 7989367  1
1994 Ceresa BP, Limbird LE. Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling. The Journal of Biological Chemistry. 269: 29557-64. PMID 7961941  1
1994 Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. The Journal of Biological Chemistry. 269: 5730-4. PMID 7907086  1
1994 Keefer JR, Nunnari J, Pang IH, Limbird LE. Introduction of purified alpha 2A-adrenergic receptors into uniformly oriented, unilamellar, phospholipid vesicles: productive coupling to G proteins but lack of receptor-dependent ion transport. Molecular Pharmacology. 45: 1071-81. PMID 7517495  1
1993 Keefer JR, Limbird LE. The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins. The Journal of Biological Chemistry. 268: 11340-7. PMID 8388390  1
1993 Kennedy ME, Limbird LE. Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. The Journal of Biological Chemistry. 268: 8003-11. PMID 8385131  1
1992 Domino SE, Repaske MG, Bonner CA, Kennedy ME, Wilson AL, Brandon S, Limbird LE. Synthesis of a yohimbine-agarose matrix useful for large-scale and micropurification of multiple alpha 2-receptor subtypes. Methods in Enzymology. 215: 181-200. PMID 1359387 DOI: 10.1016/0076-6879(92)15063-I  1
1992 Surprenant A, Horstman DA, Akbarali H, Limbird LE. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science (New York, N.Y.). 257: 977-80. PMID 1354394  1
1992 Wilson AL, Womble SW, Prakash C, Cragoe EJ, Blair IA, Limbird LE. Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange. Molecular Pharmacology. 42: 175-9. PMID 1325028  1
1991 Wilson AL, Seibert K, Brandon S, Cragoe EJ, Limbird LE. Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype. Molecular Pharmacology. 39: 481-6. PMID 1850091  1
1991 Clark JD, Limbird LE. Na(+)-H+ exchanger subtypes: a predictive review. The American Journal of Physiology. 261: C945-53. PMID 1662907  1
1990 Clarke JD, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors regulate Na(+)-H+ exchange via a cAMP-dependent mechanism. The American Journal of Physiology. 259: F977-85. PMID 2175564  0.6
1990 Horstman DA, Brandon S, Wilson AL, Guyer CA, Cragoe EJ, Limbird LE. An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. The Journal of Biological Chemistry. 265: 21590-5. PMID 2174879  1
1990 Wilson AL, Guyer CA, Cragoe EJ, Limbird LE. The hydrophobic tryptic core of the porcine alpha 2-adrenergic receptor retains allosteric modulation of binding by Na+, H+, and 5-amino-substituted amiloride analogs. The Journal of Biological Chemistry. 265: 17318-22. PMID 2170372  1
1990 Guyer CA, Horstman DA, Wilson AL, Clark JD, Cragoe EJ, Limbird LE. Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. The Journal of Biological Chemistry. 265: 17307-17. PMID 2170371  1
1989 Beebe SJ, Segaloff DL, Burks D, Beasley-Leach A, Limbird LE, Corbin JD. Evidence that cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation causes pig ovarian granulosa cell differentiation, including increases in two type II subclasses of this kinase. Biology of Reproduction. 41: 295-307. PMID 2553142  1
1988 Esser V, Limbird LE, Brown MS, Goldstein JL, Russell DW. Mutational analysis of the ligand binding domain of the low density lipoprotein receptor. The Journal of Biological Chemistry. 263: 13282-90. PMID 3417658  1
1988 Baron BM, Limbird LE. Human platelet phospholipase A2 activity is responsive in vitro to pH and Ca2+ variations which parallel those occurring after platelet activation in vivo. Biochimica Et Biophysica Acta. 971: 103-11. PMID 3408741 DOI: 10.1016/0167-4889(88)90166-8  1
1988 Sweatt JD, Connolly TM, Baron BM, Limbird LE. Involvement of Na+/H+ exchange in human platelet activation. Progress in Clinical and Biological Research. 283: 523-57. PMID 2850577  1
1988 Limbird LE. Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2686-95. PMID 2840317  1
1987 Nunnari JM, Repaske MG, Brandon S, Cragoe EJ, Limbird LE. Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange. The Journal of Biological Chemistry. 262: 12387-92. PMID 3040742  1
1987 Repaske MG, Nunnari JM, Limbird LE. Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix. The Journal of Biological Chemistry. 262: 12381-6. PMID 3040741  1
1987 Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Synthesis and characterization of arylamine derivatives of rauwolscine as molecular probes for alpha 2-adrenergic receptors. Hypertension. 9: III120-4. PMID 2885270  1
1987 Isom LL, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. The Journal of Biological Chemistry. 262: 6750-7. PMID 2883187  1
1987 Isom LL, Cragoe EJ, Limbird LE. Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation. The Journal of Biological Chemistry. 262: 17504-9. PMID 2826423  1
1987 Sweatt JD, Schwartzberg MS, Frazer M, Cragoe EJ, Blair IA, Reed PW, Limbird LE. Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. Circulation Research. 61: II6-11. PMID 2822286  1
1987 Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Synthesis and characterization of arylamine derivatives of rauwolscine as molecular probes for α2-adrenergic receptors Hypertension. 9: III-120-III-124.  1
1986 Lanier SM, Graham RM, Hess HJ, Grodski A, Repaske MG, Nunnari JM, Limbird LE, Homcy CJ. Photoaffinity labeling of the porcine brain alpha 2-adrenergic receptor using a radioiodinated arylazide derivative of rauwolscine: identification of the hormone-binding subunit. Proceedings of the National Academy of Sciences of the United States of America. 83: 9358-62. PMID 3025837  1
1986 Sweatt JD, Connolly TM, Cragoe EJ, Limbird LE. Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. The Journal of Biological Chemistry. 261: 8667-73. PMID 3013859  1
1986 Sweatt JD, Blair IA, Cragoe EJ, Limbird LE. Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step. The Journal of Biological Chemistry. 261: 8660-6. PMID 3013858  1
1985 Sweatt JD, Johnson SL, Cragoe EJ, Limbird LE. Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin. The Journal of Biological Chemistry. 260: 12910-9. PMID 2997148  1
1985 Limbird LE, Connolly TM, Sweatt JD, Uderman HD. Human platelet alpha 2-adrenergic receptors: effect of Na+ on interaction with the adenylate cyclase system and on epinephrine-stimulated platelet secretion. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 19: 235-42. PMID 2988299  1
1985 Limbird LE, MacMillan ST, Kalinoski DL. The resolution of agonist alpha 2-adrenergic receptor complexes from unoccupied receptors or antagonist-alpha 2 receptor complexes using DEAE chromatography. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 10: 75-82. PMID 2858502  1
1985 Limbird LE, Johnson SL. Evidence that Na+/H+ exchange modulates stimulus-provoked arachidonic acid (AA) mobilization in human platelets (PL) Federation Proceedings. 44: No. 4186.  1
1985 Sweatt JD, Limbird LE. Na+ and fibrinogen are required for release of arachidonic acid (AA) from human platelets in response to epinephrine, ADP and 0.004 U/ml thrombin Federation Proceedings. 44: No. 7341.  1
1984 Segaloff DL, May J, Schomberg DW, Limbird LE. A model system for the biochemical study of luteinizing hormone/chorionic gonadotropin receptor synthesis. Biochimica Et Biophysica Acta. 804: 31-6. PMID 6326843 DOI: 10.1016/0167-4889(84)90095-8  1
1984 Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Leukocyte beta-receptor alterations in hypertensive subjects. The Journal of Clinical Investigation. 73: 648-53. PMID 6323524 DOI: 10.1172/JCI111255  1
1984 Limbird LE. GTP and Na+ modulate receptor-adenyl cyclase coupling and receptor-mediated function. The American Journal of Physiology. 247: E59-68. PMID 6146263  1
1984 Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJ. Alterations in leukocyte beta-receptor affinity with aging. A potential explanation for altered beta-adrenergic sensitivity in the elderly. The New England Journal of Medicine. 310: 815-9. PMID 6142419 DOI: 10.1056/NEJM198403293101303  1
1984 Limbird LE, Connolly TM. Removal of extraplatelet Na+ eliminates indomethacin-sensitive secretion from human platelets stimulated by epinephrine, ADP and thrombin. Evidence that removal of extra-platelet Na+ limits stimulus-provoked Ca++ availability Prostaglandins. 27: 14.  1
1984 Connolly TM, Limbird LE. Evidence for a relationship between Na+ and Ca++-availability in the activation of human platelets Federation Proceedings. 43: no. 2197.  1
1983 Connolly TM, Limbird LE. Removal of extraplatelet Na+ eliminates indomethacin-sensitive secretion from human platelets stimulated by epinephrine, ADP, and thrombin. Proceedings of the National Academy of Sciences of the United States of America. 80: 5320-4. PMID 6577431  1
1983 Segaloff DL, Limbird LE. Luteinizing hormone receptor appearance in cultured porcine granulosa cells requires continual presence of follicle-stimulating hormone. Proceedings of the National Academy of Sciences of the United States of America. 80: 5631-5. PMID 6310585  1
1983 Limbird LE, Buhrow SA, Speck JL, Staros JV. 5'-p-Fluorosulfonylbenzoyl guanosine as a probe for the GTP-binding protein in alpha 2-adrenergic receptor-adenylate cyclase systems. The Journal of Biological Chemistry. 258: 10289-93. PMID 6309799  1
1983 Feldman RD, Limbird LE, Nadeau J, FitzGerald GA, Robertson D, Wood AJ. Dynamic regulation of leukocyte beta adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines. The Journal of Clinical Investigation. 72: 164-70. PMID 6308044  1
1983 Segaloff DL, Limbird LE. The cAMP-Dependent induction of LH receptors in primary cultures of porcine granulosa cells is not due to the expression of an intracellular pool of LH receptors. Endocrinology. 113: 825-7. PMID 6307657 DOI: 10.1210/endo-113-2-825  1
1983 Connolly TM, Limbird LE. The influence of Na+ on the alpha 2-adrenergic receptor system of human platelets. A method for removal of extraplatelet Na+. Effect of Na+ removal on aggregation, secretion, and cAMP accumulation. The Journal of Biological Chemistry. 258: 3907-12. PMID 6300061  1
1983 Limbird LE, Speck JL. N-ethylmaleimide, elevated temperature, and digitonin solubilization eliminate guanine nucleotide but not sodium effects on human platelet alpha 2-adrenergic receptor-agonist interactions. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 9: 191-201. PMID 6142062  1
1983 Limbird LE. Beta-adrenergic stimulation of adenylate cyclase and alpha-adrenergic inhibition of adenylate cyclase: GTP-binding proteins as macromolecular messengers. Advances in Experimental Medicine and Biology. 161: 91-111. PMID 6135310  1
1983 Limbird LE. α2-Adrenergic systems: models for exploring hormonal inhibition of adenylate cyclase Trends in Pharmacological Sciences. 4: 135-138. DOI: 10.1016/0165-6147(83)90331-0  1
1982 Smith SK, Limbird LE. Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin. The Journal of Biological Chemistry. 257: 10471-8. PMID 6286654  1
1982 Limbird LE, Speck JL, Smith SK. Sodium ion modulates agonist and antagonist interactions with the human platelet alpha 2-adrenergic receptor in membrane and solubilized preparations. Molecular Pharmacology. 21: 609-17. PMID 6125876  1
1982 Feldman R, Nadeau J, Limbird L. Modulation of beta adrenoreceptor affinity and response parallels dynamic changes in human sympathetic activity Clinical Research. 30: 251A.  1
1982 Limbird LE, Speck JL, Smith SK. Human platelet α2 adrenergic receptors (αAR): site(s) that confers sensitivity to Na+ is distinct from that mediating effects of GTP Federation Proceedings. 41: No. 3680.  1
1982 Connolly TM, Limbird LE. Removal of extracellular Na+ selectively diminishes responsiveness of human platelets to epinephrine (EPI) Federation Proceedings. 41: No. 4958.  1
1982 Smith SK, Limbird LE. Apparent independence of the alpha-adrenergic receptor (α-AR) of the human platelet from the ADP-ribosylated 42,000 Mr subunit of the adenylate cyclase system Federation Proceedings. 41: No. 3682.  1
1981 Limbird LE, MacMillan ST. Mn2+-uncoupling of the catecholamine-sensitive adenylate cyclase system of rat reticulocytes. Parallel effects on cholera toxin-catalyzed ADP-ribosylation of the system. Biochimica Et Biophysica Acta. 677: 408-16. PMID 7295804 DOI: 10.1016/0304-4165(81)90254-3  1
1981 Limbird LE. Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor--cyclase coupling. The Biochemical Journal. 195: 1-13. PMID 6272740  1
1981 Smith SK, Limbird LE. Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions. Proceedings of the National Academy of Sciences of the United States of America. 78: 4026-30. PMID 6270654  1
1981 Lefkowitz RJ, De Lean A, Hoffman BB, Stadel JM, Kent R, Michel T, Limbird L. Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. Advances in Cyclic Nucleotide Research. 14: 145-61. PMID 6269377  1
1981 Stadel JM, Shorr RG, Limbird LE, Lefkowitz RJ. Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. The Journal of Biological Chemistry. 256: 8718-23. PMID 6267049  1
1981 Limbird LE, MacMillan ST, Smith SK. Solubilization of human platelet alpha-adrenergic receptors: evidence for agonist-promoted receptor-effector association. Advances in Cyclic Nucleotide Research. 14: 189-98. PMID 6116384  1
1981 Smith SK, Limbird LE. Isolation of agonist (AG)-promoted α-adrenergic receptor (αAR)-effector complexes (AG.R) from human platelet membranes Federation Proceedings. 40: 1086.  1
1980 Limbird LE, Gill DM, Lefkowitz RJ. Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proceedings of the National Academy of Sciences of the United States of America. 77: 775-9. PMID 6244585  1
1980 Limbird LE, Gill DM, Stadel JM, Hickey AR, Lefkowitz RJ. Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. The Journal of Biological Chemistry. 255: 1854-61. PMID 6243651  1
1979 Limbird LE, Hickey AR, Lefkowitz RJ. The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. Journal of Cyclic Nucleotide Research. 5: 251-9. PMID 573291  1
1979 Limbird LE, Hickey AR, Lefkowitz RJ. Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. The Journal of Biological Chemistry. 254: 2677-83. PMID 429310  1
1979 Caron MG, Limbird LE, Lefkowitz RJ. Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. Molecular and Cellular Biochemistry. 28: 45-66. PMID 231201 DOI: 10.1007/BF00223359  1
1979 Limbird LE, DeLean A, Hickey AR, Pike LJ, Lefkowitz RJ. Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. Biochimica Et Biophysica Acta. 586: 298-314. PMID 224939 DOI: 10.1016/0304-4165(79)90101-6  1
1979 Pike LJ, Limbird LE, Lefkowitz RJ. Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. Nature. 280: 502-4. PMID 37448 DOI: 10.1038/280502a0  1
1978 Lefkowitz RJ, Limbird LE, Williams LT, Wessels M. Beta-adrenergic receptors: regulatory role of agonists. Journal of Supramolecular Structure. 8: 501-10. PMID 31515 DOI: 10.1002/jss.400080412  1
1978 Limbird LE, Lefkowitz RJ. Agonist-induced increase in apparent beta-adrenergic receptor size. Proceedings of the National Academy of Sciences of the United States of America. 75: 228-32. PMID 24213  1
1978 Limbird LE, Lefkowitz RJ. Agonist induced increase in apparent β-adrenergic receptor size Federation Proceedings. 37: No.718.  1
1977 Limbird LE, Lefkowitz RJ. Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. The Journal of Biological Chemistry. 252: 799-802. PMID 833154  1
1977 Limbird LE, Lefkowitz RJ. Separation of β-adrenergic receptors (βAR) from adenylate cyclase (AC) Federation Proceedings. 36: No.2437.  1
1976 Limbird LE, Lefkowitz RJ. Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. Molecular Pharmacology. 12: 559-67. PMID 958206  1
1976 Limbird LE, Lefkowitz RJ. Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. The Journal of Biological Chemistry. 251: 5007-14. PMID 956174  1
1976 Jarmakani JM, Limbird L, Graham TC, Marks RA. Effect of reperfusion on myocardial infarct, and the accuracy of estimating infarct size from serum creatine phosphokinase in the dog. Cardiovascular Research. 10: 245-53. PMID 938992 DOI: 10.1093/cvrese/10.2.245  1
1976 Lefkowitz RJ, Mukherjee C, Limbird LE, Caron MG, Williams LT, Alexander RW, Mickey JV, Tate R. Regulation of adenylate cyclase coupled beta-adrenergic receptors. Recent Progress in Hormone Research. 32: 597-632. PMID 785560  1
1976 Lefkowitz RJ, Limbird LE, Mukherjee C, Caron MG. The beta-adrenergic receptor and adenylate cyclase. Biochimica Et Biophysica Acta. 457: 1-39. PMID 769837 DOI: 10.1016/0304-4157(76)90012-5  1
1976 Lefkowitz RJ, Limbird LE. Techniques for the study of the biochemical basis of drug action. Progress in Cardiovascular Diseases. 18: 309-21. PMID 737 DOI: 10.1016/0033-0620(76)90024-4  1
1975 Limbird LE, Meyts PD, Lefkowitz RJ. Beta-adrenergic receptors: evidence for negative cooperativity. Biochemical and Biophysical Research Communications. 64: 1160-8. PMID 1137592 DOI: 10.1016/0006-291X(75)90815-3  1
1975 Limbird LE, Lefkowitz RJ. Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. Biochimica Et Biophysica Acta. 377: 186-96. PMID 235292 DOI: 10.1016/0005-2744(75)90299-5  1
1975 Limbird L, Lefkowitz R. Effects of membrane perturbation on β adrenergic receptor binding and adenylate cyclase activation Federation Proceedings. 34: No.643.  1
1974 Limbird LE, Lefkowitz RJ. Myocardial guanylate cyclase (GC): in vivo target of acetylcholine (ACh) Circulation. 50: No. 742.  1
1973 Wagner GS, Roe CR, Limbird LE, Rosati RA, Wallace AG. The importance of identification of the myocardial-specific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction. Circulation. 47: 263-9. PMID 4684926  1
1973 Dixon SH, Limbird LE, Roe CR, Wagner GS, Oldham NH, Sabiston DC. Recognition of postoperative acute myocardial infarction. Application of isoenzyme techniques. Circulation. 48: III137-40. PMID 4541741  1
1972 Roe CR, Limbird LE, Wagner GS, Nerenberg ST. Combined isoenzyme analysis in the diagnosis of myocardial injury: application of electrophoretic methods for the detection and quantitation of the creatine phosphokinase MB isoenzyme. The Journal of Laboratory and Clinical Medicine. 80: 577-90. PMID 5073897  1
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