Todd D. Gould, M.D. - Publications

Departments of Psychiatry, Pharmacology, and Anatomy & Neurobiology University of Maryland School of Medicine, Baltimore, MD, United States 

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zanos P, Brown KA, Georgiou P, Yuan P, Zarate CA, Thompson SM, Gould TD. NMDA RECEPTOR ACTIVATION-DEPENDENT ANTIDEPRESSANT-RELEVANT BEHAVIORAL AND SYNAPTIC ACTIONS OF KETAMINE. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36596696 DOI: 10.1523/JNEUROSCI.1316-22.2022  0.819
2022 Brown KA, Zanos P, Powels CF, Fix CJ, Michaelides M, Pereira EFR, Moaddel R, Gould TD. Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters. Neuropharmacology. 225: 109403. PMID 36565852 DOI: 10.1016/j.neuropharm.2022.109403  0.646
2022 Georgiou P, Zanos P, Mou TM, An X, Gerhard DM, Dryanovski DI, Potter LE, Highland JN, Jenne CE, Stewart BW, Pultorak KJ, Yuan P, Powels CF, Lovett J, Pereira EFR, ... ... Gould TD, et al. Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nature Neuroscience. PMID 36042309 DOI: 10.1038/s41593-022-01146-x  0.777
2022 Bonaventura J, Gomez JL, Carlton ML, Lam S, Sanchez-Soto M, Morris PJ, Moaddel R, Kang HJ, Zanos P, Gould TD, Thomas CJ, Sibley DR, Zarate CA, Michaelides M. Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search. Molecular Psychiatry. PMID 35768639 DOI: 10.1038/s41380-022-01673-w  0.628
2022 Riggs LM, Thompson SM, Gould TD. (2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity. Neuropharmacology. 214: 109153. PMID 35661657 DOI: 10.1016/j.neuropharm.2022.109153  0.785
2022 Hasin N, Riggs LM, Shekhtman T, Ashworth J, Lease R, Oshone RT, Humphries EM, Badner JA, Thomson PA, Glahn DC, Craig DW, Edenberg HJ, Gershon ES, McMahon FJ, Nurnberger JI, ... ... Gould TD, et al. Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Molecular Psychiatry. PMID 35546635 DOI: 10.1038/s41380-022-01609-4  0.738
2022 Moaddel R, Zanos P, Farmer CA, Kadriu B, Morris PJ, Lovett J, Acevedo-Diaz EE, Cavanaugh GW, Yuan P, Yavi M, Thomas CJ, Park LT, Ferrucci L, Gould TD, Zarate CA. Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration. Translational Psychiatry. 12: 179. PMID 35501309 DOI: 10.1038/s41398-022-01941-x  0.661
2022 Highland JN, Morris PJ, Konrath KM, Riggs LM, Hagen NR, Zanos P, Powels CF, Moaddel R, Thomas CJ, Wang AQ, Gould TD. Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (26)- and (5)-Methyl-(26)-hydroxynorketamines. Acs Chemical Neuroscience. 13: 510-523. PMID 35113535 DOI: 10.1021/acschemneuro.1c00761  0.799
2021 Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biological Psychiatry. PMID 35120711 DOI: 10.1016/j.biopsych.2021.11.024  0.788
2021 Highland JN, Farmer CA, Zanos P, Lovett J, Zarate CA, Moaddel R, Gould TD. Sex-dependent metabolism of ketamine and ()-hydroxynorketamine in mice and humans. Journal of Psychopharmacology (Oxford, England). 2698811211064922. PMID 34971525 DOI: 10.1177/02698811211064922  0.784
2021 Hess EM, Riggs LM, Michaelides M, Gould TD. Mechanisms of Ketamine and its Metabolites as Antidepressants. Biochemical Pharmacology. 114892. PMID 34968492 DOI: 10.1016/j.bcp.2021.114892  0.782
2021 Riggs LM, An X, Pereira EFR, Gould TD. (R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency. Translational Psychiatry. 11: 583. PMID 34772915 DOI: 10.1038/s41398-021-01685-0  0.731
2021 Morris PJ, Burke RD, Sharma AK, Lynch DC, Lemke-Boutcher LE, Mathew S, Elayan I, Rao DB, Gould TD, Zarate CA, Zanos P, Moaddel R, Thomas CJ. A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801. Neurotoxicology and Teratology. 106993. PMID 33945878 DOI: 10.1016/  0.639
2021 Highland JN, Zanos P, Riggs LM, Georgiou P, Clark SM, Morris PJ, Moaddel R, Thomas CJ, Zarate CA, Pereira EFR, Gould TD. Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications. Pharmacological Reviews. 73: 763-791. PMID 33674359 DOI: 10.1124/pharmrev.120.000149  0.81
2021 Riggs LM, Gould TD. Ketamine and the Future of Rapid-Acting Antidepressants. Annual Review of Clinical Psychology. PMID 33561364 DOI: 10.1146/annurev-clinpsy-072120-014126  0.756
2020 Elmer GI, Tapocik JD, Mayo CL, Zanos P, Gould TD. Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma. Pharmacology, Biochemistry, and Behavior. 172973. PMID 32569786 DOI: 10.1016/J.Pbb.2020.172973  0.679
2020 Farmer CA, Gilbert JR, Moaddel R, George J, Adeojo L, Lovett J, Nugent AC, Kadriu B, Yuan P, Gould TD, Park LT, Zarate CA. Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32252062 DOI: 10.1038/S41386-020-0663-6  0.329
2020 Park LT, Kadriu B, Gould TD, Zanos P, Greenstein D, Evans JW, Yuan P, Farmer CA, Oppenheimer M, George JM, Adeojo LW, Snodgrass HR, Smith MA, Henter ID, Machado-Vieira R, et al. A Randomized Trial of the N-methyl-d-aspartate Receptor Glycine Site Antagonist Prodrug 4-chlorokynurenine in Treatment-Resistant Depression. The International Journal of Neuropsychopharmacology. PMID 32236521 DOI: 10.1093/Ijnp/Pyaa025  0.681
2020 Zhang Y, Zanos P, Jackson IL, Zhang X, Zhu X, Gould T, Vujaskovic Z. Psychological stress enhances tumor growth and diminishes radiation response in preclinical model of lung cancer. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 146: 126-135. PMID 32146258 DOI: 10.1016/J.Radonc.2020.02.004  0.611
2020 Potter LE, Zanos P, Gould TD. Antidepressant Effects and Mechanisms of Group II mGlu Receptor-Specific Negative Allosteric Modulators. Neuron. 105: 1-3. PMID 31951525 DOI: 10.1016/J.Neuron.2019.12.011  0.79
2020 Wang AQ, Konrath KM, Highland JN, Riggs LM, Morris PJ, Thomas C, Gould TD, Xu X. P199 - HILIC UPLC-MS/MS methods for the assessment of hydroxynorketamines pharmacokinetics in mouse plasma and brain Drug Metabolism and Pharmacokinetics. 35. DOI: 10.1016/J.Dmpk.2020.04.200  0.75
2019 Krimmel SR, Zanos P, Georgiou P, Colloca L, Gould TD. Classical conditioning of antidepressant placebo effects in mice. Psychopharmacology. PMID 31422429 DOI: 10.1007/S00213-019-05347-4  0.8
2019 Riggs LM, Aracava Y, Zanos P, Fischell J, Albuquerque EX, Pereira EFR, Thompson SM, Gould TD. (2R,6R)-hydroxynorketamine acts through a synapse-specific presynaptic mechanism to rapidly potentiate hippocampal glutamatergic transmission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31216563 DOI: 10.1038/S41386-019-0443-3  0.787
2019 Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD. (R)-ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anesthetic doses. British Journal of Pharmacology. PMID 30941749 DOI: 10.1111/Bph.14683  0.771
2019 Highland JN, Zanos P, Georgiou P, Gould TD. Group II metabotropic glutamate receptor blockade promotes stress resilience in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30939596 DOI: 10.1038/S41386-019-0380-1  0.801
2019 Zanos P, Highland JN, Stewart BW, Georgiou P, Jenne CE, Lovett J, Morris PJ, Thomas CJ, Moaddel R, Zarate CA, Gould TD. ()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America. PMID 30867285 DOI: 10.1073/Pnas.1819540116  0.809
2019 Georgiou P, Zanos P, Jenne CE, Gould TD. Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation. Frontiers in Psychiatry. 10: 81. PMID 30863326 DOI: 10.3389/Fpsyt.2019.00081  0.805
2019 Rao X, Asico LD, Zanos P, Mahabeleshwar GH, Singh Gangwar R, Xia C, Duan L, Cisse YM, Rengasamy P, Jose PA, Gould TD, Nelson R, Biswal S, Chen LC, Zhong J, et al. Alpha2B-Adrenergic Receptor Overexpression in the Brain Potentiate Air Pollution-induced Behavior and Blood Pressure Changes. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30812033 DOI: 10.1093/Toxsci/Kfz025  0.656
2019 Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA, ... ... Gould TD, et al. Antidepressant-relevant concentrations of the ketamine metabolite (2,6)-hydroxynorketamine do not block NMDA receptor function. Proceedings of the National Academy of Sciences of the United States of America. PMID 30796190 DOI: 10.1073/Pnas.1816071116  0.807
2018 Highland JN, Morris PJ, Zanos P, Lovett J, Ghosh S, Wang AQ, Zarate CA, Thomas CJ, Moaddel R, Gould TD. Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine. Journal of Psychopharmacology (Oxford, England). 269881118812095. PMID 30488740 DOI: 10.1177/0269881118812095  0.796
2018 Gould TD, Zarate CA, Thompson SM. Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants. Annual Review of Pharmacology and Toxicology. PMID 30296896 DOI: 10.1146/Annurev-Pharmtox-010617-052811  0.643
2018 Moaddel R, Shardell M, Khadeer M, Lovett J, Kadriu B, Ravichandran S, Morris PJ, Yuan P, Thomas CJ, Gould TD, Ferrucci L, Zarate CA. Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects. Psychopharmacology. PMID 30116859 DOI: 10.1007/S00213-018-4992-7  0.373
2018 Jarvela TS, Womack T, Georgiou P, Gould TD, Eriksen JL, Lindberg I. 7B2 chaperone knockout in APP model mice results in reduced plaque burden. Scientific Reports. 8: 9813. PMID 29955078 DOI: 10.1038/S41598-018-28031-7  0.68
2018 Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA, Gould TD. Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms. Pharmacological Reviews. 70: 621-660. PMID 29945898 DOI: 10.1124/Pr.117.015198  0.791
2018 Royal W, Can A, Gould TD, Guo M, Huse J, Jackson M, Davis H, Bryant J. Cigarette smoke and nicotine effects on brain proinflammatory responses and behavioral and motor function in HIV-1 transgenic rats. Journal of Neurovirology. PMID 29644536 DOI: 10.1007/S13365-018-0623-7  0.68
2018 Brown PL, Zanos P, Wang L, Elmer GI, Gould TD, Shepard PD. Isoflurane but not Halothane Prevents and Reverses Helpless Behavior: A Role for EEG Burst Suppression? The International Journal of Neuropsychopharmacology. PMID 29554264 DOI: 10.1093/Ijnp/Pyy029  0.675
2018 Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Molecular Psychiatry. PMID 29532791 DOI: 10.1038/Mp.2017.255  0.706
2018 Zanos P, Thompson SM, Duman RS, Zarate CA, Gould TD. Convergent Mechanisms Underlying Rapid Antidepressant Action. Cns Drugs. PMID 29516301 DOI: 10.1007/S40263-018-0492-X  0.79
2018 Nugent AC, Ballard ED, Gould TD, Park LT, Moaddel R, Brutsche NE, Zarate CA. Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects. Molecular Psychiatry. PMID 29487402 DOI: 10.1038/S41380-018-0028-2  0.314
2018 Zanos P, Gould TD. Intracellular Signaling Pathways Involved in (S)- and (R)-Ketamine Antidepressant Actions. Biological Psychiatry. 83: 2-4. PMID 29173705 DOI: 10.1016/J.Biopsych.2017.10.026  0.657
2018 Georgiou P, Zanos P, Jenne C, Highland J, Gerhard D, Duman R, Gould T. F102. Human Experimenter Sex Modulates Mouse Behavioral Responses to Stress and to the Antidepressant Ketamine Biological Psychiatry. 83: S277. DOI: 10.1016/J.Biopsych.2018.02.715  0.778
2018 Highland J, Zanos P, Georgiou P, Gould T. T89. Group II Metabotropic Glutamate Receptor Blockade Promotes Stress Resilience Biological Psychiatry. 83: S163. DOI: 10.1016/J.Biopsych.2018.02.425  0.764
2017 Morris PJ, Moaddel R, Zanos P, Moore CE, Gould TD, Zarate CA, Thomas CJ. Correction to "Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites". Organic Letters. PMID 28933164 DOI: 10.1021/Acs.Orglett.7B02839  0.638
2017 Morris PJ, Moaddel R, Zanos P, Moore CE, Gould T, Zarate CA, Thomas CJ. Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites. Organic Letters. PMID 28829612 DOI: 10.1021/Acs.Orglett.7B02177  0.654
2017 Georgiou P, Zanos P, Bhat S, Tracy JK, Merchenthaler IJ, McCarthy MM, Gould TD. Dopamine and Stress System Modulation of Sex Differences in Decision Making. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28741626 DOI: 10.1038/Npp.2017.161  0.772
2017 Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KSS, Fang Y, Huang XP, Mayo CL, Albuquerque EX, ... ... Gould TD, et al. Zanos et al. reply. Nature. 546: E4-E5. PMID 28640272 DOI: 10.1038/Nature22085  0.738
2017 Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson ZR, Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry CA, Renshaw PF, Rujescu D, Smith EG, et al. Animal models to improve our understanding and treatment of suicidal behavior. Translational Psychiatry. 7: e1092. PMID 28398339 DOI: 10.1038/Tp.2017.50  0.782
2017 Zanos P, Nelson ME, Highland JN, Krimmel SR, Georgiou P, Gould TD, Thompson SM. A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice. Eneuro. 4. PMID 28275719 DOI: 10.1523/ENEURO.0285-16.2017  0.798
2017 Terrillion CE, Dao DT, Cachope R, Lobo MK, Puche AC, Cheer JF, Gould TD. Reduced levels of Cacna1c attenuate mesolimbic dopamine system function. Genes, Brain, and Behavior. PMID 28186690 DOI: 10.1111/Gbb.12371  0.795
2017 Terrillion CE, Francis TC, Puche AC, Lobo MK, Gould TD. Decreased nucleus accumbens expression of psychiatric disorder risk gene Cacna1c promotes susceptibility to social stress. The International Journal of Neuropsychopharmacology. PMID 28165117 DOI: 10.1093/Ijnp/Pyw112  0.718
2017 Gould TD, Zanos P, Zarate CA. Ketamine Mechanism of Action: Separating the Wheat from the Chaff. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 42: 368-369. PMID 27909322 DOI: 10.1038/Npp.2016.210  0.638
2017 Zanos P, Moaddel R, Morris P, Georgiou P, Fischell J, Elmer G, Alkondon M, Yuan P, Pribut H, Singh N, Dossou K, Fang Y, Huang X, Mayo C, Wainer I, ... ... Gould T, et al. 790. Ketamine Exerts NMDAR Inhibition-Independent Antidepressant Actions via Its Hydroxynorketamine Metabolites Biological Psychiatry. 81: S321. DOI: 10.1016/J.Biopsych.2017.02.857  0.785
2017 Zarate C, Gould T, Zanos P, Machado-Vieira R. 80. Theories on the Mechanism of Action of Ketamine: From NMDA Receptor Inhibition to the (2R,6R)-HNK Metabolite Biological Psychiatry. 81: S33-S34. DOI: 10.1016/J.Biopsych.2017.02.092  0.66
2016 Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, et al. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27834214 DOI: 10.1073/Pnas.1608432113  0.748
2016 Zanos P, Moaddel R, Morris PJ, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA, Gould TD. Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine. Biological Psychiatry. PMID 27817846 DOI: 10.1016/J.Biopsych.2016.08.039  0.757
2016 Can A, Frost DO, Cachope R, Cheer JF, Gould TD. Chronic Lithium Treatment Rectifies Maladaptive Dopamine Release in the Nucleus Accumbens. Journal of Neurochemistry. PMID 27513916 DOI: 10.1111/Jnc.13769  0.698
2016 Can A, Zanos P, Moaddel R, Kang HJ, Dossou KS, Wainer IW, Cheer JF, Frost DO, Huang XP, Gould TD. Effects of ketamine and ketamine metabolites on evoked striatal dopamine release, dopamine receptors, and monoamine transporters. The Journal of Pharmacology and Experimental Therapeutics. PMID 27469513 DOI: 10.1124/Jpet.116.235838  0.805
2016 Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, ... ... Gould TD, et al. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. PMID 27144355 DOI: 10.1038/Nature17998  0.801
2015 Kop WJ, Galvao TF, Synowski SJ, Xu W, Can A, O'Shea KM, Gould TD, Stanley WC. Effects of environmental stress following myocardial infarction on behavioral measures and heart failure progression: The influence of isolated and group housing conditions. Physiology & Behavior. 152: 168-174. PMID 26423786 DOI: 10.1016/J.Physbeh.2015.09.024  0.694
2015 Zanos P, Piantadosi SC, Wu HQ, Pribut HJ, Dell MJ, Can A, Snodgrass HR, Zarate CA, Schwarcz R, Gould TD. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. The Journal of Pharmacology and Experimental Therapeutics. 355: 76-85. PMID 26265321 DOI: 10.1124/Jpet.115.225664  0.804
2015 Lee RS, Pirooznia M, Guintivano J, Ly M, Ewald ER, Tamashiro KL, Gould TD, Moran TH, Potash JB. Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene. Translational Psychiatry. 5: e600. PMID 26171981 DOI: 10.1038/Tp.2015.90  0.325
2015 Zanos P, Bhat S, Terrillion CE, Smith RJ, Tonelli LH, Gould TD. Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav 1.2). The European Journal of Neuroscience. PMID 25989111 DOI: 10.1111/Ejn.12952  0.764
2015 Pezzato FA, Can A, Hoshino K, Horta Jde A, Mijares MG, Gould TD. Effect of lithium on behavioral disinhibition induced by electrolytic lesion of the median raphe nucleus. Psychopharmacology. 232: 1441-50. PMID 25345734 DOI: 10.1007/S00213-014-3775-Z  0.795
2014 Can A, Schulze TG, Gould TD. Molecular actions and clinical pharmacogenetics of lithium therapy. Pharmacology, Biochemistry, and Behavior. 123: 3-16. PMID 24534415 DOI: 10.1016/J.Pbb.2014.02.004  0.742
2014 Clark SM, Sand J, Francis TC, Nagaraju A, Michael KC, Keegan AD, Kusnecov A, Gould TD, Tonelli LH. Immune status influences fear and anxiety responses in mice after acute stress exposure. Brain, Behavior, and Immunity. 38: 192-201. PMID 24524915 DOI: 10.1016/J.Bbi.2014.02.001  0.326
2014 Safren N, El Ayadi A, Chang L, Terrillion CE, Gould TD, Boehning DF, Monteiro MJ. Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease. Plos One. 9: e87513. PMID 24475300 DOI: 10.1371/Journal.Pone.0087513  0.736
2014 Guintivano J, Arad M, Gould TD, Payne JL, Kaminsky ZA. Antenatal prediction of postpartum depression with blood DNA methylation biomarkers. Molecular Psychiatry. 19: 560-7. PMID 23689534 DOI: 10.1016/J.Comppsych.2014.08.017  0.306
2013 Halcomb ME, Gould TD, Grahame NJ. Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1937-44. PMID 23584261 DOI: 10.1038/Npp.2013.89  0.385
2013 Can A, Piantadosi SC, Gould TD. Differential antidepressant-like response to lithium treatment between mouse strains: effects of sex, maternal care, and mixed genetic background. Psychopharmacology. 228: 411-8. PMID 23503701 DOI: 10.1007/S00213-013-3045-5  0.794
2012 Bhat S, Dao DT, Terrillion CE, Arad M, Smith RJ, Soldatov NM, Gould TD. CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Progress in Neurobiology. 99: 1-14. PMID 22705413 DOI: 10.1016/J.Pneurobio.2012.06.001  0.787
2012 Can A, Dao DT, Terrillion CE, Piantadosi SC, Bhat S, Gould TD. The tail suspension test. Journal of Visualized Experiments : Jove. e3769. PMID 22315011 DOI: 10.3791/3769  0.777
2012 Can A, Dao DT, Arad M, Terrillion CE, Piantadosi SC, Gould TD. The mouse forced swim test. Journal of Visualized Experiments : Jove. e3638. PMID 22314943 DOI: 10.3791/3638  0.785
2012 Gould TD, Can A, Gottesman II, Courtet P. Differential lithium efficacy in reducing suicidal behaviors compared with suicidal thoughts. The American Journal of Psychiatry. 169: 98-9; author reply 9. PMID 22223017 DOI: 10.1176/Appi.Ajp.2011.11081220  0.745
2012 Can A, Grahame NJ, Gould TD. Affect-related behaviors in mice selectively bred for high and low voluntary alcohol consumption. Behavior Genetics. 42: 313-22. PMID 21989731 DOI: 10.1007/S10519-011-9505-Y  0.722
2011 Courtet P, Gottesman II, Jollant F, Gould TD. The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? Translational Psychiatry. 1. PMID 21761009 DOI: 10.1038/Tp.2011.6  0.495
2011 Can A, Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC, Gould TD. Antidepressant-like responses to lithium in genetically diverse mouse strains. Genes, Brain, and Behavior. 10: 434-43. PMID 21306560 DOI: 10.1111/J.1601-183X.2011.00682.X  0.788
2011 Kas MJ, Krishnan V, Gould TD, Collier DA, Olivier B, Lesch KP, Domenici E, Fuchs E, Gross C, Castrén E. Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 532-44. PMID 21237620 DOI: 10.1016/J.Euroneuro.2010.12.001  0.321
2010 Dao DT, Mahon PB, Cai X, Kovacsics CE, Blackwell RA, Arad M, Shi J, Zandi PP, O'Donnell P, Knowles JA, Weissman MM, Coryell W, Scheftner WA, Lawson WB, ... ... Gould TD, et al. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biological Psychiatry. 68: 801-10. PMID 20723887 DOI: 10.1016/J.Biopsych.2010.06.019  0.793
2010 Kovacsics CE, Gould TD. Shock-induced aggression in mice is modified by lithium. Pharmacology, Biochemistry, and Behavior. 94: 380-6. PMID 19800363 DOI: 10.1016/J.Pbb.2009.09.020  0.801
2009 Tonelli LH, Katz M, Kovacsics CE, Gould TD, Joppy B, Hoshino A, Hoffman G, Komarow H, Postolache TT. Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents. Brain, Behavior, and Immunity. 23: 784-93. PMID 19268702 DOI: 10.1016/J.Bbi.2009.02.017  0.797
2009 Kovacsics CE, Gottesman II, Gould TD. Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategies. Annual Review of Pharmacology and Toxicology. 49: 175-98. PMID 18834309 DOI: 10.1146/Annurev.Pharmtox.011008.145557  0.795
2009 Tonelli L, Katz M, Kovacsis C, Gould T, Postolache T. Experimentally Induced Allergic Rhinitis Induces Anxiety-like Behavior and Altered Social Interaction in Rodents Journal of Allergy and Clinical Immunology. 123: S155-S155. DOI: 10.1016/J.Jaci.2008.12.580  0.301
2008 Gould TD, O'Donnell KC, Picchini AM, Dow ER, Chen G, Manji HK. Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. Behavioural Brain Research. 189: 117-25. PMID 18299155 DOI: 10.1016/J.Bbr.2007.12.028  0.785
2008 Gould TD, O'Donnell KC, Dow ER, Du J, Chen G, Manji HK. Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test. Neuropharmacology. 54: 577-87. PMID 18096191 DOI: 10.1016/J.Neuropharm.2007.11.002  0.815
2008 Gould T, Kovacsics C, O'Donnell K, Dow E, Chen G, Manji H. S.20.04 Lithium responsive behavioural models: a tool for understanding atypical antipsychotic action in bipolar depression and mania European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70191-3  0.543
2007 Gould TD, Einat H. Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement. Neuroscience and Biobehavioral Reviews. 31: 825-31. PMID 17628675 DOI: 10.1016/J.Neubiorev.2007.05.007  0.326
2007 O'Donnell KC, Gould TD. The behavioral actions of lithium in rodent models: leads to develop novel therapeutics. Neuroscience and Biobehavioral Reviews. 31: 932-62. PMID 17532044 DOI: 10.1016/J.Neubiorev.2007.04.002  0.805
2007 Gould TD, Dow ER, O'Donnell KC, Chen G, Manji HK. Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway. Cns & Neurological Disorders Drug Targets. 6: 193-204. PMID 17511616 DOI: 10.2174/187152707780619308  0.786
2007 Gould NF, Holmes MK, Fantie BD, Luckenbaugh DA, Pine DS, Gould TD, Burgess N, Manji HK, Zarate CA. Performance on a virtual reality spatial memory navigation task in depressed patients. The American Journal of Psychiatry. 164: 516-9. PMID 17329478 DOI: 10.1176/Ajp.2007.164.3.516  0.5
2007 Gould TD, Einat H, O'Donnell KC, Picchini AM, Schloesser RJ, Manji HK. Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2173-83. PMID 17299510 DOI: 10.1038/Sj.Npp.1301338  0.782
2007 Gould TD, O'Donnell KC, Picchini AM, Manji HK. Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1321-33. PMID 17151598 DOI: 10.1038/Sj.Npp.1301254  0.778
2006 Gould TD, Picchini AM, Einat H, Manji HK. Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders. Current Drug Targets. 7: 1399-409. PMID 17100580 DOI: 10.2174/1389450110607011399  0.806
2006 Gould TD. Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications. Expert Opinion On Therapeutic Targets. 10: 377-92. PMID 16706678 DOI: 10.1517/14728222.10.3.377  0.338
2006 Gould TD, Gottesman II. Psychiatric endophenotypes and the development of valid animal models. Genes, Brain, and Behavior. 5: 113-9. PMID 16507002 DOI: 10.1111/J.1601-183X.2005.00186.X  0.536
2006 Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. Toward constructing an endophenotype strategy for bipolar disorders. Biological Psychiatry. 60: 93-105. PMID 16406007 DOI: 10.1016/J.Biopsych.2005.11.006  0.646
2005 Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Molecular Neurobiology. 32: 173-202. PMID 16215281 DOI: 10.1385/Mn:32:2:173  0.552
2005 Gould TD, Manji HK. Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1223-37. PMID 15827567 DOI: 10.1038/Sj.Npp.1300731  0.556
2005 Gould TD, Manji HK. DARPP-32: A molecular switch at the nexus of reward pathway plasticity. Proceedings of the National Academy of Sciences of the United States of America. 102: 253-4. PMID 15632217 DOI: 10.1073/Pnas.0408700102  0.522
2005 Quiroz JA, Singh J, Gould TD, Denicoff KD, Zarate CA, Manji HK. Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology. Molecular Psychiatry. 9: 756-76. PMID 15136795 DOI: 10.1038/Sj.Mp.4001521  0.545
2005 Gould TD, Quiroz JA, Singh J, Zarate CA, Manji HK. Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Molecular Psychiatry. 9: 734-55. PMID 15136794 DOI: 10.1038/Sj.Mp.4001518  0.55
2005 Yuan PX, Zhou R, Farzad N, Gould TD, Gray NA, Du J, Manji HK. Chapter 5.7 Enhancing resilience to stress: the role of signaling cascades Techniques in the Behavioral and Neural Sciences. 15: 751-771. DOI: 10.1016/S0921-0709(05)80040-9  0.545
2004 Quiroz JA, Gould TD, Manji HK. Molecular effects of lithium. Molecular Interventions. 4: 259-72. PMID 15471909 DOI: 10.1124/Mi.4.5.6  0.543
2004 Gould TD, Einat H, Bhat R, Manji HK. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. The International Journal of Neuropsychopharmacology. 7: 387-90. PMID 15315719 DOI: 10.1017/S1461145704004535  0.553
2004 Hao Y, Creson T, Zhang L, Li P, Du F, Yuan P, Gould TD, Manji HK, Chen G. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6590-9. PMID 15269271 DOI: 10.1523/Jneurosci.5747-03.2004  0.531
2004 Gould TD, Manji HK. The molecular medicine revolution and psychiatry: bridging the gap between basic neuroscience research and clinical psychiatry. The Journal of Clinical Psychiatry. 65: 598-604. PMID 15163244 DOI: 10.4088/Jcp.V65N0502  0.493
2004 Gould TD, Zarate CA, Manji HK. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. The Journal of Clinical Psychiatry. 65: 10-21. PMID 14744163  0.47
2004 Einat H, Manji HK, Gould TD, Du J, Chen G. Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice. Drug News & Perspectives. 16: 453-63. PMID 14668941 DOI: 10.1358/DNP.2003.16.7.829357  0.527
2004 Gould TD, Chen G, Manji HK. In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 32-8. PMID 12942141 DOI: 10.1038/Sj.Npp.1300283  0.508
2004 Picchini AM, Manji HK, Gould TD. GSK-3 and neurotrophic signaling: novel targets underlying the pathophysiology and treatment of mood disorders? Drug Discovery Today: Disease Mechanisms. 1: 419-428. DOI: 10.1016/J.Ddmec.2004.11.020  0.794
2004 Yuan P, Gould TD, Gray NA, Bachmann RF, Schloesser RJ, Lan MJK, Du J, Moore GJ, Manji HK. Neurotrophic signaling cascades are major long-term targets for lithium: Clinical implications Clinical Neuroscience Research. 4: 137-153. DOI: 10.1016/J.Cnr.2004.09.006  0.543
2004 Gould TD, Zarate CA, Manji HK. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. The Journal of Clinical Psychiatry. 65: 10-21. DOI: 10.1002/0470052171.Ch7  0.53
2003 Manji HK, Gottesman II, Gould TD. Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe49. PMID 14600293 DOI: 10.1126/Stke.2003.207.Pe49  0.642
2003 Einat H, Yuan P, Gould TD, Li J, Du J, Zhang L, Manji HK, Chen G. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7311-6. PMID 12917364 DOI: 10.1523/Jneurosci.23-19-07311.2003  0.542
2003 Gould TD, Gray NA, Manji HK. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacological Research. 48: 49-53. PMID 12770514 DOI: 10.1016/S1043-6618(03)00096-3  0.526
2003 Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. The American Journal of Psychiatry. 160: 636-45. PMID 12668349 DOI: 10.1176/Appi.Ajp.160.4.636  0.502
2003 Li J, Gould TD, Yuan P, Manji HK, Chen G. Post-mortem interval effects on the phosphorylation of signaling proteins. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1017-25. PMID 12637955 DOI: 10.1038/Sj.Npp.1300112  0.485
2002 Gould TD, Chen G, Manji HK. Mood stabilizer psychopharmacology. Clinical Neuroscience Research. 2: 193-212. PMID 22707923 DOI: 10.1016/S1566-2772(02)00044-0  0.541
2002 Gould TD, Manji HK. The Wnt signaling pathway in bipolar disorder. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 497-511. PMID 12374432 DOI: 10.1177/107385802237176  0.528
2002 Gould TD, Manji HK. Signaling networks in the pathophysiology and treatment of mood disorders. Journal of Psychosomatic Research. 53: 687-97. PMID 12169343 DOI: 10.1016/S0022-3999(02)00426-9  0.535
2002 Lenox RH, Gould TD, Manji HK. Endophenotypes in bipolar disorder. American Journal of Medical Genetics. 114: 391-406. PMID 11992561 DOI: 10.1002/Ajmg.10360  0.537
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