| Year |
Citation |
Score |
| 2020 |
McAlary L, Yerbury JJ, Cashman NR. The prion-like nature of amyotrophic lateral sclerosis. Progress in Molecular Biology and Translational Science. 175: 261-296. PMID 32958236 DOI: 10.1016/Bs.Pmbts.2020.07.002 |
0.398 |
|
| 2020 |
Plotkin SS, Cashman NR. Passive immunotherapies targeting Aβ and tau in Alzheimer's disease. Neurobiology of Disease. 105010. PMID 32682954 DOI: 10.1016/J.Nbd.2020.105010 |
0.388 |
|
| 2020 |
Wright GSA, Watanabe TF, Amporndanai K, Plotkin SS, Cashman NR, Antonyuk SV, Hasnain SS. Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases. Iscience. 23: 101159. PMID 32480125 DOI: 10.1016/J.Isci.2020.101159 |
0.32 |
|
| 2020 |
Khorvash M, Blinov N, Ladner-Keay C, Lu J, Silverman JM, Gibbs E, Wang YT, Kovalenko A, Wishart D, Cashman NR. Molecular interactions between monoclonal oligomer-specific antibody 5E3 and its amyloid beta cognates. Plos One. 15: e0232266. PMID 32469918 DOI: 10.1371/Journal.Pone.0232266 |
0.326 |
|
| 2020 |
Semmler S, Gagné M, Garg P, Pickles SR, Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E, Bayne AN, Trempe JF, Cashman NR, Star AT, Haqqani AS, et al. TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation. The Journal of Biological Chemistry. PMID 32029478 DOI: 10.1074/Jbc.Ra119.011215 |
0.351 |
|
| 2020 |
Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI. Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection. Plos One. 15: e0227655. PMID 31999698 DOI: 10.1371/Journal.Pone.0227655 |
0.338 |
|
| 2019 |
McAlary L, Plotkin SS, Yerbury JJ, Cashman NR. Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis. Frontiers in Molecular Neuroscience. 12: 311. PMID 32038158 DOI: 10.3389/Fnmol.2019.00311 |
0.322 |
|
| 2019 |
McAlary L, Plotkin SS, Yerbury JJ, Cashman NR. Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis. Frontiers in Molecular Neuroscience. 12: 262. PMID 31736708 DOI: 10.3389/Fnmol.2019.00262 |
0.401 |
|
| 2019 |
McAlary L, Plotkin SS, Cashman NR. Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases. Cns Drugs. PMID 31414322 DOI: 10.1007/S40263-019-00657-9 |
0.386 |
|
| 2019 |
Zhao B, Marciniuk K, Gibbs E, Yousefi M, Napper S, Cashman NR. Therapeutic vaccines for amyotrophic lateral sclerosis directed against disease specific epitopes of superoxide dismutase 1. Vaccine. PMID 31324499 DOI: 10.1016/J.Vaccine.2019.07.044 |
0.369 |
|
| 2019 |
Gibbs E, Silverman JM, Zhao B, Peng X, Wang J, Wellington CL, Mackenzie IR, Plotkin SS, Kaplan JM, Cashman NR. A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease. Scientific Reports. 9: 9870. PMID 31285517 DOI: 10.1038/S41598-019-46306-5 |
0.347 |
|
| 2019 |
Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR. CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1) ALS mice originate from astrocytes and neurons and carry misfolded SOD1. The Journal of Biological Chemistry. PMID 30635404 DOI: 10.1074/Jbc.Ra118.004825 |
0.336 |
|
| 2019 |
Pokrishevsky E, Nan J, Cashman NR. Induction of Cu/Zn Superoxide Dismutase (SOD1) Aggregation in Living Cells. Methods in Molecular Biology (Clifton, N.J.). 1873: 213-224. PMID 30341612 DOI: 10.1007/978-1-4939-8820-4_13 |
0.36 |
|
| 2019 |
Kaplan J, Gibbs E, Silverman JM, Zhao B, Wang J, Peng X, Plotkin SS, Cashman NR. Selective Targeting Of Amyloid-Beta Oligomer Species By Pmn310, A Monoclonal Antibody Rationally Designed For Greater Therapeutic Potency In Alzheimer’S Disease Alzheimers & Dementia. 15: 1628. DOI: 10.1016/J.Jalz.2019.06.4864 |
0.317 |
|
| 2018 |
DuVal MG, Hinge VK, Snyder N, Kanyo R, Bratvold J, Pokrishevsky E, Cashman NR, Blinov N, Kovalenko A, Allison WT. Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics. Neurobiology of Disease. 124: 297-310. PMID 30528257 DOI: 10.1016/J.Nbd.2018.11.025 |
0.334 |
|
| 2018 |
Peng X, Cashman NR, Plotkin SS. Prediction of Misfolding-Specific Epitopes in SOD1 Using Collective Coordinates. The Journal of Physical Chemistry. B. PMID 30351123 DOI: 10.1021/Acs.Jpcb.8B07680 |
0.301 |
|
| 2018 |
Pokrishevsky E, McAlary L, Farrawell NE, Zhao B, Sher M, Yerbury JJ, Cashman NR. Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells. Scientific Reports. 8: 15590. PMID 30349065 DOI: 10.1038/S41598-018-32835-Y |
0.359 |
|
| 2018 |
Paré B, Lehmann M, Beaudin M, Nordström U, Saikali S, Julien JP, Gilthorpe JD, Marklund SL, Cashman NR, Andersen PM, Forsberg K, Dupré N, Gould P, Brännström T, Gros-Louis F. Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis. Scientific Reports. 8: 14223. PMID 30242181 DOI: 10.1038/S41598-018-31773-Z |
0.371 |
|
| 2018 |
Ladner-Keay CL, Ross L, Perez-Pineiro R, Zhang L, Bjorndahl TC, Cashman N, Wishart DS. A Simple In Vitro Assay for Assessing the Efficacy, Mechanisms and Kinetics of Anti-Prion Fibril Compounds. Prion. PMID 30223704 DOI: 10.1080/19336896.2018.1525254 |
0.328 |
|
| 2018 |
Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G. Investigation of anti-SOD1 antibodies yields new structural insight into SOD1 misfolding and surprising behavior of the antibodies themselves. Acs Chemical Biology. PMID 30110532 DOI: 10.1021/Acschembio.8B00729 |
0.312 |
|
| 2018 |
Ayers JI, Cashman NR. Prion-like mechanisms in amyotrophic lateral sclerosis. Handbook of Clinical Neurology. 153: 337-354. PMID 29887144 DOI: 10.1016/B978-0-444-63945-5.00018-0 |
0.387 |
|
| 2018 |
Silverman J, Gibbs E, Peng X, Martens K, Balducci C, Wang J, Yousefi M, Cowan CM, Lamour G, Louadi S, Ban Y, Robert J, Stukas S, Forloni G, Hsiung GR, ... ... Cashman NR, et al. A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers. Acs Chemical Neuroscience. PMID 29614860 DOI: 10.1021/Acschemneuro.7B00469 |
0.352 |
|
| 2018 |
Xue YC, Feuer R, Cashman N, Luo H. Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis? Frontiers in Molecular Neuroscience. 11: 63. PMID 29593492 DOI: 10.3389/Fnmol.2018.00063 |
0.334 |
|
| 2018 |
Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, et al. A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles. Plos Pathogens. 14: e1006826. PMID 29338055 DOI: 10.1371/Journal.Ppat.1006826 |
0.35 |
|
| 2017 |
Pokrishevsky E, Hong RH, Mackenzie IR, Cashman NR. Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells. Plos One. 12: e0184384. PMID 28877271 DOI: 10.1371/Journal.Pone.0184384 |
0.378 |
|
| 2017 |
Grad LI, Pokrishevsky E, Cashman NR. Intercellular Prion-Like Conversion and Transmission of Cu/Zn Superoxide Dismutase (SOD1) in Cell Culture. Methods in Molecular Biology (Clifton, N.J.). 1658: 357-367. PMID 28861801 DOI: 10.1007/978-1-4939-7244-9_24 |
0.37 |
|
| 2017 |
Robert J, Button EB, Stukas S, Boyce GK, Gibbs E, Cowan CM, Gilmour M, Cheng WH, Soo SK, Yuen B, Bahrabadi A, Kang K, Kulic I, Francis G, Cashman N, et al. High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture. Molecular Neurodegeneration. 12: 60. PMID 28830501 DOI: 10.1186/S13024-017-0201-0 |
0.305 |
|
| 2017 |
Kaplan J, Silverman JM, Gibbs E, Wang J, Peng X, Plotkin SS, Cashman NR. TARGETING OF TOXIC AMYLOID-BETA OLIGOMER SPECIES BY MONOCLONAL ANTIBODY PMN310: PRECISION DRUG DESIGN FOR ALZHEIMER’S DISEASE Alzheimer's & Dementia. 13: P592. DOI: 10.1016/J.Jalz.2017.07.225 |
0.309 |
|
| 2016 |
Grad LI, Rouleau GA, Ravits J, Cashman NR. Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS). Cold Spring Harbor Perspectives in Medicine. PMID 28003278 DOI: 10.1101/Cshperspect.A024117 |
0.344 |
|
| 2016 |
Beraldo FH, Ostapchenko VG, Caetano FA, Guimaraes AL, Ferretti GD, Daude N, Bertram L, Nogueira KO, Silva JL, Westaway D, Cashman NR, Martins VR, Prado VF, Prado MA. Regulation of Amyloid β oligomer binding to neurons and neurotoxicity by the complex prion protein/mGluR5. The Journal of Biological Chemistry. PMID 27563063 DOI: 10.1074/Jbc.M116.738286 |
0.337 |
|
| 2016 |
Pickles S, Semmler S, Broom HR, Destroismaisons L, Legroux L, Arbour N, Meiering E, Cashman NR, Vande Velde C. ALS-linked misfolded SOD1 species have divergent impacts on mitochondria. Acta Neuropathologica Communications. 4: 43. PMID 27121871 DOI: 10.1186/S40478-016-0313-8 |
0.337 |
|
| 2016 |
Pokrishevsky E, Grad LI, Cashman NR. TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion. Scientific Reports. 6: 22155. PMID 26926802 DOI: 10.1038/Srep22155 |
0.381 |
|
| 2016 |
Silverman JM, Fernando SM, Grad LI, Hill AF, Turner BJ, Yerbury JJ, Cashman NR. Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways. Cellular and Molecular Neurobiology. PMID 26908139 DOI: 10.1007/S10571-015-0294-3 |
0.388 |
|
| 2016 |
Yerbury JJ, Ooi L, Dillin A, Saunders DN, Hatters DM, Beart PM, Cashman NR, Wilson MR, Ecroyd H. Walking the tightrope: Proteostasis and neurodegenerative disease. Journal of Neurochemistry. PMID 26872075 DOI: 10.1111/Jnc.13575 |
0.394 |
|
| 2016 |
Coulthart MB, Jansen GH, Cashman NR. Evidence for transmissibility of Alzheimer disease pathology: Cause for concern? Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. PMID 26833733 DOI: 10.1503/Cmaj.151257 |
0.307 |
|
| 2016 |
Gibbs E, Silverman JM, Wellington C, Cashman NR. P3-047: The Amyloid-Beta (Aβ) Oligomer-Specific CYCLIC-SER-ASN-LYS (CSNK) Tripeptide is Highly Immunogenic and Induces Sustained Levels of ANTI-CSNK Antibodies of the IGG1 Subclass Alzheimer's & Dementia. 12: P834-P835. DOI: 10.1016/J.Jalz.2016.06.1705 |
0.309 |
|
| 2016 |
Peng X, Guest WC, Cashman NR, Plotkin SS. A Simple Method for Predicting Cancer Specific Cell Surface Epitopes Biophysical Journal. 110: 326a. DOI: 10.1016/J.Bpj.2015.11.1751 |
0.312 |
|
| 2015 |
Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, et al. SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Molecular Neurodegeneration. 10: 57. PMID 26520394 DOI: 10.1186/S13024-015-0053-4 |
0.367 |
|
| 2015 |
Mackenzie IR, Frick P, Grässer FA, Gendron TF, Petrucelli L, Cashman NR, Edbauer D, Kremmer E, Prudlo J, Troost D, Neumann M. Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. Acta Neuropathologica. PMID 26374446 DOI: 10.1007/S00401-015-1476-2 |
0.363 |
|
| 2015 |
Taschuk R, Van der Merwe J, Marciniuk K, Potter A, Cashman N, Griebel P, Napper S. In vitro neutralization of prions with PrP(Sc)-specific antibodies. Prion. 9: 292-303. PMID 26284508 DOI: 10.1080/19336896.2015.1071761 |
0.315 |
|
| 2015 |
Johnson CJ, Carlson CM, Morawski AR, Manthei A, Cashman NR. Assessing transmissible spongiform encephalopathy species barriers with an in vitro prion protein conversion assay. Journal of Visualized Experiments : Jove. PMID 25867521 DOI: 10.3791/52522 |
0.306 |
|
| 2015 |
Grad LI, Fernando SM, Cashman NR. From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis. Neurobiology of Disease. 77: 257-65. PMID 25701498 DOI: 10.1016/J.Nbd.2015.02.009 |
0.422 |
|
| 2015 |
Nykiforuk CL, Johnstone D, Reid R, Hrehorak B, Merluza J, Cheung P, Kodihalli S, Dupas B, Leonhardt M, Hoffman H, Han X, Saward L, Goertzen A, Jackson M, Silverman JM, ... ... Cashman NR, et al. O4-04-01: Characterization of a humanized amyloid beta oligomer monoclonal antibody (5E3) under preclinical development for passive immunotherapy of Alzheimer's disease Alzheimer's & Dementia. 11: P275-P275. DOI: 10.1016/J.Jalz.2015.07.363 |
0.335 |
|
| 2015 |
Silverman JM, Gibbs E, Balducci C, Cowan C, Lamour G, Forloni G, Robin Hsiung G, Saward L, Wellington C, Cashman NR. O1-05-04: An amyloid-beta oligomer epitope specific for toxic assemblages in Alzheimer's disease Alzheimer's & Dementia. 11: P136-P137. DOI: 10.1016/J.Jalz.2015.07.054 |
0.327 |
|
| 2014 |
Grad LI, Pokrishevsky E, Silverman JM, Cashman NR. Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding. Prion. 8: 331-5. PMID 25551548 DOI: 10.4161/19336896.2014.983398 |
0.378 |
|
| 2014 |
Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi LM, Yousefi M, Coleman BM, Hill AF, ... ... Cashman NR, et al. Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 111: 3620-5. PMID 24550511 DOI: 10.1073/Pnas.1312245111 |
0.381 |
|
| 2014 |
Taschuk R, Marciniuk K, Määttänen P, Madampage C, Hedlin P, Potter A, Lee J, Cashman NR, Griebel PJ, Napper S. Safety, specificity and immunogenicity of a PrP(Sc)-specific prion vaccine based on the YYR disease specific epitope. Prion. 8: 51-9. PMID 24509522 DOI: 10.4161/Pri.27962 |
0.328 |
|
| 2014 |
Coulthart MB, Jansen GH, Cashman NR. Interpretation of cerebrospinal fluid protein tests in the diagnosis of sporadic Creutzfeldt-Jakob disease: an evidence-based approach. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 186: E333-9. PMID 24446456 DOI: 10.1503/Cmaj.130720 |
0.353 |
|
| 2014 |
Grad LI, Cashman NR. Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis. Prion. 8: 33-41. PMID 24394345 DOI: 10.4161/Pri.27602 |
0.409 |
|
| 2014 |
Nykiforuk C, Johnstone D, Silverman JM, Gibbs E, Kodihalli S, Emanuel A, Cheung P, Masi A, Cassan R, Han X, Wellington C, Cashman NR, Saward L. P4-371: PRECLINICAL DEVELOPMENT OF AN AMYLOID-B OLIGMER (ABO) SPECIFIC MONOCLONAL ANTIBODY (5E3) FOR POTENTIAL PASSIVE IMMUNOTHERAPY OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P924-P924. DOI: 10.1016/J.Jalz.2014.07.140 |
0.327 |
|
| 2014 |
Uger M, Cashman NR, Lee V, Mutukura T, Plawinski E, Gundel R. P4-286: SEPARATE DETECTION OF AGGREGATED AB40 AND AGGREGATED AB42 IN CSF FROM ALZHEIMER'S DISEASE PATIENTS USING THE AMORFIX EP-AD DIAGNOSTIC CSF TEST Alzheimer's & Dementia. 10: P889-P889. DOI: 10.1016/J.Jalz.2014.07.057 |
0.317 |
|
| 2014 |
Gibbs E, Cashman NR, Silverman J, Bertram L, Wellington C, Nykiforuk CL, Masi A, Cassan R, Han X, Kodihalli S, Saward L. P2-397: MICE IMMUNIZED WITH CYCLIC-SER-ASN-LYS (CSNK) PEPTIDE GENERATE POLYCLONAL ANTIBODIES SELECTIVE FOR Aβ OLIGOMERS: A VACCINE STRATEGY FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P624-P624. DOI: 10.1016/J.Jalz.2014.05.1077 |
0.301 |
|
| 2013 |
Madampage CA, Marciniuk K, Määttänen P, Cashman NR, Potter A, Lee JS, Napper S. Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes. Prion. 7: 511-9. PMID 24401607 DOI: 10.4161/Pri.27502 |
0.311 |
|
| 2013 |
Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. The Journal of Biological Chemistry. 288: 37241-55. PMID 24225951 DOI: 10.1074/Jbc.M113.488650 |
0.322 |
|
| 2013 |
Ostapchenko VG, Beraldo FH, Mohammad AH, Xie YF, Hirata PH, Magalhaes AC, Lamour G, Li H, Maciejewski A, Belrose JC, Teixeira BL, Fahnestock M, Ferreira ST, Cashman NR, Hajj GN, et al. The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16552-64. PMID 24133259 DOI: 10.1523/Jneurosci.3214-13.2013 |
0.316 |
|
| 2013 |
Määttänen P, Taschuk R, Ross L, Marciniuk K, Bertram L, Potter A, Cashman NR, Napper S. PrP(Sc)-specific antibodies do not induce prion disease or misfolding of PrP(C) in highly susceptible Tga20 mice. Prion. 7: 434-9. PMID 24105298 DOI: 10.4161/Pri.26639 |
0.331 |
|
| 2013 |
Madampage CA, Määttänen P, Marciniuk K, Brownlie R, Andrievskaia O, Potter A, Cashman NR, Lee JS, Napper S. Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: potential implications for immunotherapy of familial prion diseases. Prion. 7: 301-11. PMID 23787697 DOI: 10.4161/Pri.25148 |
0.372 |
|
| 2013 |
Jetha NN, Semenchenko V, Wishart DS, Cashman NR, Marziali A. Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics. Plos One. 8: e54982. PMID 23393562 DOI: 10.1371/Journal.Pone.0054982 |
0.319 |
|
| 2013 |
Uger MD, Chai V, Ciolfi V, Chen H, Plawinski E, Mutukura T, Sage A, Demers R, Lau L, Lee P, Liu X, Guan J, Wang Y, Guest WC, Plotkin SS, ... Cashman NR, et al. Abstract 4636: AMF-1c-120: an antibody specific for misfolded prion protein expressed on ovarian cancer cells. Cancer Research. 73: 4636-4636. DOI: 10.1158/1538-7445.Am2013-4636 |
0.333 |
|
| 2013 |
Gibbs E, Silverman J, Balducci C, Wang J, Chen H, Uger M, Masi A, Ostapchenko V, Prado M, Song W, Forloni G, Wellington C, Saward L, Cashman N. P4-289: Normal healthy donors possess plasma IgG reactive to a neutralizing epitope for toxic and amyloid-seeding beta-amyloid oligomers Alzheimer's & Dementia. 9: P810-P810. DOI: 10.1016/J.Jalz.2013.05.1682 |
0.318 |
|
| 2013 |
Plotkin SS, Cashman NR, Das A. Computational Prediction of ALS Patient Survival Times from Protein Mechanical Properties Biophysical Journal. 104: 577a. DOI: 10.1016/J.Bpj.2012.11.3206 |
0.338 |
|
| 2012 |
Pokrishevsky E, Grad LI, Yousefi M, Wang J, Mackenzie IR, Cashman NR. Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis. Plos One. 7: e35050. PMID 22493728 DOI: 10.1371/Journal.Pone.0035050 |
0.344 |
|
| 2012 |
Toth D, Pronyk R, Blanchard M, Tighe B, Han X, Yousefi M, Cashman N, Saward L. P1-228: Naturally occurring human antibodies to misfolded Aβ epitope associated with Alzheimer's disease Alzheimer's & Dementia. 8: P187-P187. DOI: 10.1016/J.Jalz.2012.05.507 |
0.347 |
|
| 2012 |
Silverman J, Gibbs E, Rezaei H, Grznarova K, Guest W, Song W, Robin Hsiung G, Deslys J, Roucou X, Wellington C, Cashman N. O4-06-03: An immunological epitope specific for toxic oligomeric Aß in Alzheimer's disease Alzheimer's & Dementia. 8: P625-P625. DOI: 10.1016/J.Jalz.2012.05.1666 |
0.307 |
|
| 2012 |
Samuel Plotkin S, Cashman NR, Das A, Guest W. Template-Directed Protein Misfolding in Silico and in the Cell Biophysical Journal. 102: 474a. DOI: 10.1016/J.Bpj.2011.11.2599 |
0.31 |
|
| 2011 |
Guest WC, Silverman JM, Pokrishevsky E, O'Neill MA, Grad LI, Cashman NR. Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit. Journal of Toxicology and Environmental Health. Part A. 74: 1433-59. PMID 22043906 DOI: 10.1080/15287394.2011.618967 |
0.371 |
|
| 2011 |
Grad LI, Guest WC, Yanai A, Pokrishevsky E, O'Neill MA, Gibbs E, Semenchenko V, Yousefi M, Wishart DS, Plotkin SS, Cashman NR. Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 16398-403. PMID 21930926 DOI: 10.1073/Pnas.1102645108 |
0.37 |
|
| 2011 |
Taghibiglou C, Lu J, Mackenzie IR, Wang YT, Cashman NR. Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide. Biochemical and Biophysical Research Communications. 413: 159-63. PMID 21871872 DOI: 10.1016/J.Bbrc.2011.08.011 |
0.33 |
|
| 2011 |
Perez-Pineiro R, Bjorndahl TC, Berjanskii MV, Hau D, Li L, Huang A, Lee R, Gibbs E, Ladner C, Dong YW, Abera A, Cashman NR, Wishart DS. The prion protein binds thiamine. The Febs Journal. 278: 4002-14. PMID 21848803 DOI: 10.1111/J.1742-4658.2011.08304.X |
0.302 |
|
| 2011 |
Julien O, Chatterjee S, Bjorndahl TC, Sweeting B, Acharya S, Semenchenko V, Chakrabartty A, Pai EF, Wishart DS, Sykes BD, Cashman NR. Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies. Biochemistry. 50: 7536-45. PMID 21800884 DOI: 10.1021/Bi200731E |
0.303 |
|
| 2011 |
Vanderperre B, Staskevicius AB, Tremblay G, McCoy M, O'Neill MA, Cashman NR, Roucou X. An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2373-86. PMID 21478263 DOI: 10.1096/Fj.10-173815 |
0.344 |
|
| 2011 |
Van Dorsselaer A, Carapito C, Delalande F, Schaeffer-Reiss C, Thierse D, Diemer H, McNair DS, Krewski D, Cashman NR. Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach. Plos One. 6: e17815. PMID 21448279 DOI: 10.1371/Journal.Pone.0017815 |
0.317 |
|
| 2011 |
Ryu H, Jeon GS, Cashman NR, Kowall NW, Lee J. Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 342-52. PMID 21283077 DOI: 10.1038/Labinvest.2010.203 |
0.328 |
|
| 2011 |
Hinnell C, Coulthart MB, Jansen GH, Cashman NR, Lauzon J, Clark A, Costello F, White C, Midha R, Wiebe S, Furtado S. Gerstmann-Straussler-Scheinker disease due to a novel prion protein gene mutation. Neurology. 76: 485-7. PMID 21282596 DOI: 10.1212/Wnl.0B013E31820A0Ab2 |
0.312 |
|
| 2010 |
Khan MQ, Sweeting B, Mulligan VK, Arslan PE, Cashman NR, Pai EF, Chakrabartty A. Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proceedings of the National Academy of Sciences of the United States of America. 107: 19808-13. PMID 21041683 DOI: 10.1073/Pnas.1005267107 |
0.316 |
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| 2010 |
Li L, Napper S, Cashman NR. Immunotherapy for prion diseases: opportunities and obstacles. Immunotherapy. 2: 269-82. PMID 20635933 DOI: 10.2217/Imt.10.3 |
0.329 |
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| 2010 |
Rademakers R, Stewart H, Dejesus-Hernandez M, Krieger C, Graff-Radford N, Fabros M, Briemberg H, Cashman N, Eisen A, Mackenzie IR. Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis. Muscle & Nerve. 42: 170-6. PMID 20544928 DOI: 10.1002/Mus.21665 |
0.307 |
|
| 2010 |
Scrocchi LA, Karaskov E, Lee V, Chen H, Osborne M, Lehto MT, Uger MD, Cashman NR, Kus B, Lutz CM, Sasner M. Early detection of β-amyloid aggregation in in vivo and in vitro models of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.724 |
0.319 |
|
| 2010 |
Grad LI, Donkin J, O'Neill MA, Wang J, Scrocchi LA, Wellington CL, Cashman NR. Misfolded superoxide dismutase 1 (SOD1) as a novel target for Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1920 |
0.319 |
|
| 2010 |
Plotkin S, Cashman N, Guest W. Computational Prediction of Hotspots in Protein Misfolding for Rational Immunotherapy Biophysical Journal. 98: 638a. DOI: 10.1016/J.Bpj.2009.12.3494 |
0.333 |
|
| 2009 |
Wong M, Toth J, Haney S, Tyshenko MG, Darshan S, Krewski D, Leighton FA, Westaway D, Moore SS, Ricketts M, Cashman N. Prionet Canada: A network of centres of excellence for research into prions and prion diseases Journal of Toxicology and Environmental Health - Part a: Current Issues. 72: 1000-1007. PMID 19697232 DOI: 10.1080/15287390903084108 |
0.314 |
|
| 2009 |
Haddon DJ, Hughes MR, Antignano F, Westaway D, Cashman NR, McNagny KM. Prion protein expression and release by mast cells after activation. The Journal of Infectious Diseases. 200: 827-31. PMID 19642931 DOI: 10.1086/605022 |
0.333 |
|
| 2009 |
Li L, Guest W, Huang A, Plotkin SS, Cashman NR. Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding. Protein Engineering, Design & Selection : Peds. 22: 523-9. PMID 19602568 DOI: 10.1093/Protein/Gzp038 |
0.336 |
|
| 2008 |
Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, ... ... Cashman NR, et al. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. Plos Genetics. 4: e1000193. PMID 18802454 DOI: 10.1371/Journal.Pgen.1000193 |
0.338 |
|
| 2008 |
Cashman N, Tan LY, Krieger C, Mädler B, Mackay A, Mackenzie I, Benny B, Nantel S, Fabros M, Shinobu L, Yousefi M, Eisen A. Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS). Muscle & Nerve. 37: 620-5. PMID 18335482 DOI: 10.1002/Mus.20951 |
0.304 |
|
| 2008 |
Tabata RC, Wilson JMB, Ly P, Zwiegers P, Kwok D, Van Kampen JM, Cashman N, Shaw CA. Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype Neuromolecular Medicine. 10: 24-39. PMID 18196479 DOI: 10.1007/S12017-007-8020-Z |
0.34 |
|
| 2008 |
Yuan J, Dong Z, Guo JP, McGeehan J, Xiao X, Wang J, Cali I, McGeer PL, Cashman NR, Bessen R, Surewicz WK, Kneale G, Petersen RB, Gambetti P, Zou WQ. Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cellular and Molecular Life Sciences : Cmls. 65: 631-43. PMID 18193391 DOI: 10.1007/S00018-007-7478-Z |
0.336 |
|
| 2007 |
Li L, Coulthart MB, Balachandran A, Chakrabartty A, Cashman NR. Species barriers for chronic wasting disease by in vitro conversion of prion protein. Biochemical and Biophysical Research Communications. 364: 796-800. PMID 17964288 DOI: 10.1016/J.Bbrc.2007.10.087 |
0.307 |
|
| 2007 |
Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth DM, Griffin J, Cleveland DW, Cashman NR, Chakrabartty A. An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nature Medicine. 13: 754-9. PMID 17486090 DOI: 10.1038/Nm1559 |
0.36 |
|
| 2007 |
Griffin JK, Terry LA, Jackman R, Yousefi M, Cashman NR. Decreased cell surface prion protein in mouse models of prion disease. Neuroreport. 18: 1-6. PMID 17259851 DOI: 10.1097/01.Wnr.0000239967.06438.21 |
0.379 |
|
| 2006 |
Lehto MT, Peery HE, Cashman NR. Current and future molecular diagnostics for prion diseases. Expert Review of Molecular Diagnostics. 6: 597-611. PMID 16824033 DOI: 10.1586/14737159.6.4.597 |
0.346 |
|
| 2005 |
Mazzoni IE, Ledebur HC, Paramithiotis E, Cashman N. Lymphoid signal transduction mechanisms linked to cellular prion protein. Biochemistry and Cell Biology. 83: 644-653. PMID 16234853 DOI: 10.1139/O05-058 |
0.31 |
|
| 2005 |
Griffin JK, Cashman NR. Progress in prion vaccines and immunotherapies. Expert Opinion On Biological Therapy. 5: 97-110. PMID 15709913 DOI: 10.1517/14712598.5.1.97 |
0.361 |
|
| 2004 |
Fukada K, Zhang F, Vien A, Cashman NR, Zhu H. Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis. Molecular & Cellular Proteomics : McP. 3: 1211-23. PMID 15501831 DOI: 10.1074/Mcp.M400094-Mcp200 |
0.32 |
|
| 2004 |
Cashman NR, Caughey B. Prion diseases--close to effective therapy? Nature Reviews. Drug Discovery. 3: 874-84. PMID 15459678 DOI: 10.1038/Nrd1525 |
0.34 |
|
| 2004 |
Rakhit R, Crow JP, Lepock JR, Kondejewski LH, Cashman NR, Chakrabartty A. Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 279: 15499-504. PMID 14734542 DOI: 10.1074/Jbc.M313295200 |
0.325 |
|
| 2004 |
Paramithiotis E, Pinard M, Lawton T, LaBoissiere S, Leathers VL, Zou W, Estey LA, Lamontagne J, Lehto MT, Kondejewski LH, Francoeur GP, Papadopoulos M, Haghighat A, Spatz SJ, Head M, ... ... Cashman NR, et al. Reply to “Properties of a disease-specific prion probe” Nature Medicine. 10: 11-12. DOI: 10.1038/Nm0104-11B |
0.32 |
|
| 2003 |
Paramithiotis E, Pinard M, Lawton T, LaBoissiere S, Leathers VL, Zou WQ, Estey LA, Lamontagne J, Lehto MT, Kondejewski LH, Francoeur GP, Papadopoulos M, Haghighat A, Spatz SJ, Head M, ... ... Cashman NR, et al. A prion protein epitope selective for the pathologically misfolded conformation. Nature Medicine. 9: 893-9. PMID 12778138 DOI: 10.1038/Nm883 |
0.373 |
|
| 2002 |
Rakhit R, Cunningham P, Furtos-Matei A, Dahan S, Qi XF, Crow JP, Cashman NR, Kondejewski LH, Chakrabartty A. Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 277: 47551-6. PMID 12356748 DOI: 10.1074/Jbc.M207356200 |
0.345 |
|
| 2001 |
Zou WQ, Yang DS, Fraser PE, Cashman NR, Chakrabartty A. All or none fibrillogenesis of a prion peptide. European Journal of Biochemistry / Febs. 268: 4885-91. PMID 11559357 DOI: 10.1046/J.1432-1327.2001.02415.X |
0.3 |
|
| 2001 |
Usuki S, Ren J, Utsunomiya I, Cashman NR, Inokuchi J, Miyatake T. GM2 ganglioside regulates the function of ciliary neurotrophic factor receptor in murine immortalized motor neuron-like cells (NSC-34). Neurochemical Research. 26: 375-82. PMID 11495348 DOI: 10.1023/A:1010999014657 |
0.316 |
|
| 2001 |
Morelon E, Dodelet V, Lavery P, Cashman NR, Loertscher R. The failure of Daudi cells to express the cellular prion protein is caused by a lack of glycosyl-phosphatidylinositol anchor formation. Immunology. 102: 242-7. PMID 11260330 DOI: 10.1046/J.1365-2567.2001.01166.X |
0.335 |
|
| 2000 |
Jung SS, Cashman NR. Implications of cell surface expression of the Alzheimer's beta-amyloid precursor protein Neurobiology of Aging. 21: 82-83. DOI: 10.1016/S0197-4580(00)82595-6 |
0.568 |
|
| 1999 |
Jung SS, Cashman NR. Processing of the beta-amyloid precursor protein in ex vivo human brain cells. Neuroreport. 10: 3875-9. PMID 10716226 DOI: 10.1097/00001756-199912160-00028 |
0.563 |
|
| 1999 |
Jung SS, Gauthier S, Cashman NR. Beta-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease. Neurobiology of Aging. 20: 249-57. PMID 10588572 DOI: 10.1016/S0197-4580(99)00051-2 |
0.574 |
|
| 1999 |
Kalra S, Arnold DL, Cashman NR. Biological markers in the diagnosis and treatment of ALS Journal of the Neurological Sciences. 165. PMID 10448978 DOI: 10.1016/S0022-510X(99)00023-4 |
0.323 |
|
| 1999 |
Usuki S, Cashman NR, Miyatake T. GM2 promotes ciliary neurotrophic factor-dependent rescue of immortalized motor neuron-like cell (NSC-34). Neurochemical Research. 24: 281-6. PMID 9972876 DOI: 10.1023/A:1022522306946 |
0.305 |
|
| 1999 |
Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. Journal of Neurochemistry. 72: 185-95. PMID 9886069 DOI: 10.1046/J.1471-4159.1999.0720185.X |
0.32 |
|
| 1998 |
Dodelet VC, Cashman NR. Prion protein expression in human leukocyte differentiation. Blood. 91: 1556-61. PMID 9473220 DOI: 10.1182/Blood.V91.5.1556.1556_1556_1561 |
0.338 |
|
| 1997 |
Pallister C, Jung SS, Shaw I, Nalbantoglu J, Gauthier S, Cashman NR. Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging. Neurobiology of Aging. 18: 97-103. PMID 8983037 DOI: 10.1016/S0197-4580(96)00207-2 |
0.558 |
|
| 1996 |
D'Souza SD, Bonetti B, Balasingam V, Cashman NR, Barker PA, Troutt AB, Raine CS, Antel JP. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. The Journal of Experimental Medicine. 184: 2361-70. PMID 8976190 DOI: 10.1084/Jem.184.6.2361 |
0.305 |
|
| 1996 |
Jung SS, Nalbantoglu J, Cashman NR. Alzheimer's beta-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: a flow cytometric study. Journal of Neuroscience Research. 46: 336-48. PMID 8933373 DOI: 10.1002/(Sici)1097-4547(19961101)46:3<336::Aid-Jnr7>3.0.Co;2-L |
0.557 |
|
| 1995 |
McLaurin J, Trudel GC, Shaw IT, Antel JP, Cashman NR. A human glial hybrid cell line differentially expressing genes subserving oligodendrocyte and astrocyte phenotype. Journal of Neurobiology. 26: 283-93. PMID 7707048 DOI: 10.1002/Neu.480260212 |
0.315 |
|
| 1995 |
Matsumoto A, Yoshino H, Yuki N, Hara Y, Cashman NR, Handa S, Miyatake T. Ganglioside characterization of a cell line displaying motor neuron-like phenotype: GM2 as a possible major ganglioside in motor neurons. Journal of the Neurological Sciences. 131: 111-8. PMID 7595635 DOI: 10.1016/0022-510X(95)00101-7 |
0.342 |
|
| 1995 |
Antel JP, Cashman NR. Immunological findings in amyotrophic lateral sclerosis Springer Seminars in Immunopathology. 17: 17-28. PMID 7482223 DOI: 10.1007/Bf00194097 |
0.338 |
|
| 1995 |
Ledoux S, Bergeron C, Nalbantoglu J, Gauthier S, Cashman NR. Polymerase chain reaction quantification of lymphoid amyloid precursor protein mRNAs in Alzheimer's disease and Down's syndrome Neuroscience Letters. 193: 137-139. PMID 7478160 DOI: 10.1016/0304-3940(95)11681-L |
0.327 |
|
| 1992 |
Cashman NR, Durham HD, Blusztajn JK, Oda K, Tabira T, Shaw IT, Dahrouge S, Antel JP. Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 194: 209-21. PMID 1467557 DOI: 10.1002/Aja.1001940306 |
0.309 |
|
| 1992 |
Bendheim PE, Brown HR, Rudelli RD, Scala LJ, Goller NL, Wen GY, Kascsak RJ, Cashman NR, Bolton DC. Nearly ubiquitous tissue distribution of the scrapie agent precursor protein. Neurology. 42: 149-56. PMID 1346470 DOI: 10.1212/Wnl.42.1.149 |
0.315 |
|
| 1990 |
Cashman NR, Loertscher R, Nalbantoglu J, Shaw I, Kascsak RJ, Bolton DC, Bendheim PE. Cellular isoform of the scrapie agent protein participates in lymphocyte activation Cell. 61: 185-192. PMID 1969332 DOI: 10.1016/0092-8674(90)90225-4 |
0.327 |
|
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