Wendy Noble, PhD - Publications

Affiliations: 
Department or Neuroscience King's College London, London, UK 
Area:
Alzheimer's disease, tau

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Year Citation  Score
2024 Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F, Troakes C, Golde TE, Perez-Nievas BG, Hanger DP, Noble W, Jimenez-Sanchez M. Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science Advances. 10: eadk9884. PMID 38507480 DOI: 10.1126/sciadv.adk9884  0.815
2024 Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP. Expression of Concern: Molecular motors implicated in the axonal transport of tau and α-synuclein. Journal of Cell Science. 137. PMID 38345345 DOI: 10.1242/jcs.261985  0.555
2023 Marzi SJ, Schilder BM, Nott A, Frigerio CS, Willaime-Morawek S, Bucholc M, Hanger DP, James C, Lewis PA, Lourida I, Noble W, Rodriguez-Algarra F, Sharif JA, Tsalenchuk M, Winchester LM, et al. Artificial intelligence for neurodegenerative experimental models. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37768001 DOI: 10.1002/alz.13479  0.535
2023 Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp MD, Jimenez-Sanchez M, Perkinton MS, Kassiou M, Golde TE, Hanger DP, Verkhratsky A, Perez-Nievas BG, Noble W. P2XR influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes. Brain, Behavior, and Immunity. 114: 414-429. PMID 37716378 DOI: 10.1016/j.bbi.2023.09.011  0.847
2023 Noble W, Hanger DP. Trimming away tau in neurodegeneration. Science (New York, N.Y.). 381: 377-378. PMID 37499007 DOI: 10.1126/science.adj0256  0.647
2023 Matafora V, Gorb A, Yang F, Noble W, Bachi A, Perez-Nievas BG, Jimenez-Sanchez M. Proteomics of the astrocyte secretome reveals changes in their response to soluble oligomeric Aβ. Journal of Neurochemistry. 166: 346-366. PMID 37303123 DOI: 10.1111/jnc.15875  0.419
2022 Beltran-Lobo P, Reid MJ, Jimenez-Sanchez M, Verkhratsky A, Perez-Nievas BG, Noble W. Astrocyte adaptation in Alzheimer's disease: a focus on astrocytic P2X7R. Essays in Biochemistry. PMID 36449279 DOI: 10.1042/EBC20220079  0.444
2022 Rupawala H, Shah K, Davies C, Rose J, Colom-Cadena M, Peng X, Granat L, Aljuhani M, Mizuno K, Troakes C, Perez-Nievas BG, Morgan A, So PW, Hortobagyi T, Spires-Jones TL, ... Noble W, et al. Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease. Brain Communications. 4: fcac192. PMID 35928052 DOI: 10.1093/braincomms/fcac192  0.365
2022 Gomez-Suaga P, Mórotz GM, Markovinovic A, Martín-Guerrero SM, Preza E, Arias N, Mayl K, Aabdien A, Gesheva V, Nishimura A, Annibali A, Lee Y, Mitchell JC, Wray S, Shaw C, ... Noble W, et al. Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Aging Cell. e13549. PMID 35026048 DOI: 10.1111/acel.13549  0.517
2021 Sung K, Yang F, Noble W, Jimenez-Sanchez M. Investigating the non-cell autonomous role of glial chaperones in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058572. PMID 34971177 DOI: 10.1002/alz.058572  0.433
2021 Pollack SJ, Dakkak D, Guo T, Gómez-Suaga P, Noble W, Hanger DP. Autophagy and lysosomal defects in cells expressing disease-associated tau. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058299. PMID 34971173 DOI: 10.1002/alz.058299  0.739
2021 Goniotaki D, Tamagnini F, Biasetti L, Rumpf SL, Troakes C, Pollack SJ, Ukwesa S, Sun H, Serpell L, Noble W, Staras K, Hanger DP. HCN channelopathy couples disease-associated tau to synaptic dysfunction. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058346. PMID 34971152 DOI: 10.1002/alz.058346  0.639
2021 Perez-Nievas BG, Johnson L, Beltran-Lobo P, Hughes MM, Gammallieri L, Tarsitano F, Myszczynska MA, Vazquez-Villasenor I, Jimenez-Sanchez M, Troakes C, Wharton SB, Ferraiuolo L, Noble W. Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity. Journal of Neuroinflammation. 18: 306. PMID 34963475 DOI: 10.1186/s12974-021-02371-0  0.42
2021 Derkinderen P, Rolli-Derkinderen M, Chapelet G, Neunlist M, Noble W. Tau in the gut, does it really matter? Journal of Neurochemistry. PMID 33569813 DOI: 10.1111/jnc.15320  0.376
2020 Staurenghi E, Cerrato V, Gamba P, Testa G, Giannelli S, Leoni V, Caccia C, Buffo A, Noble W, Perez-Nievas BG, Leonarduzzi G. Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2. Redox Biology. 39: 101837. PMID 33360775 DOI: 10.1016/j.redox.2020.101837  0.402
2020 Reid MJ, Beltran-Lobo P, Johnson L, Perez-Nievas BG, Noble W. Astrocytes in Tauopathies. Frontiers in Neurology. 11: 572850. PMID 33071951 DOI: 10.3389/fneur.2020.572850  0.432
2020 Lau DHW, Paillusson S, Hartopp N, Rupawala H, Mórotz GM, Gomez-Suaga P, Greig J, Troakes C, Noble W, Miller CCJ. Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain. Neurobiology of Disease. 105020. PMID 32682953 DOI: 10.1016/J.Nbd.2020.105020  0.467
2020 Glennon EB, Lau DH, Gabriele RMC, Taylor MF, Troakes C, Opie-Martin S, Elliott C, Killick R, Hanger DP, Perez-Nievas BG, Noble W. Bridging Integrator-1 protein loss in Alzheimer's disease promotes synaptic tau accumulation and disrupts tau release. Brain Communications. 2. PMID 32500121 DOI: 10.1093/braincomms/fcaa011  0.748
2020 Prigent A, Chapelet G, De Guilhem de Lataillade A, Oullier T, Durieu E, Bourreille A, Duchalais E, Hardonnière K, Neunlist M, Noble W, Kerdine-Römer S, Derkinderen P, Rolli-Derkinderen M. Tau accumulates in Crohn's disease gut. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32436623 DOI: 10.1096/Fj.202000414R  0.446
2019 Hanger DP, Goniotaki D, Noble W. Synaptic Localisation of Tau. Advances in Experimental Medicine and Biology. 1184: 105-112. PMID 32096032 DOI: 10.1007/978-981-32-9358-8_9  0.741
2019 Mórotz GM, Glennon EB, Greig J, Lau DHW, Bhembre N, Mattedi F, Muschalik N, Noble W, Vagnoni A, Miller CCJ. Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. Acta Neuropathologica Communications. 7: 200. PMID 31806024 DOI: 10.1186/S40478-019-0857-5  0.413
2019 Howard R, Zubko O, Bradley R, Harper E, Pank L, O'Brien J, Fox C, Tabet N, Livingston G, Bentham P, McShane R, Burns A, Ritchie C, Reeves S, Lovestone S, ... ... Noble W, et al. Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial. Jama Neurology. PMID 31738372 DOI: 10.1001/Jamaneurol.2019.3762  0.472
2019 Noble W, Jimenez-Sanchez M, Perez-Nievas BG, Hanger DP. Considerations for future tau-targeted therapeutics: can they deliver? Expert Opinion On Drug Discovery. 1-3. PMID 31661994 DOI: 10.1080/17460441.2020.1685977  0.648
2019 Mauricio R, Benn C, Davis J, Dawson G, Dawson LA, Evans A, Fox N, Gallacher J, Hutton M, Isaac J, Jones DNC, Jones L, Lalli G, Libri V, Lovestone S, ... ... Noble W, et al. Tackling gaps in developing life-changing treatments for dementia. Alzheimer's & Dementia (New York, N. Y.). 5: 241-253. PMID 31297438 DOI: 10.1016/J.Trci.2019.05.001  0.339
2019 Mórotz GM, Glennon EB, Gomez-Suaga P, Lau DHW, Robinson ED, Sedlák É, Vagnoni A, Noble W, Miller CCJ. LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains. Acta Neuropathologica Communications. 7: 73. PMID 31068217 DOI: 10.1186/S40478-019-0715-5  0.39
2019 Gómez-Suaga P, Pérez-Nievas BG, Glennon EB, Lau DHW, Paillusson S, Mórotz GM, Calì T, Pizzo P, Noble W, Miller CCJ. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. Acta Neuropathologica Communications. 7: 35. PMID 30841933 DOI: 10.1186/S40478-019-0688-4  0.376
2019 Guo T, Dakkak D, Rodriguez-Martin T, Noble W, Hanger DP. A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response. Acta Neuropathologica Communications. 7: 2. PMID 30606258 DOI: 10.1186/s40478-018-0651-9  0.703
2018 Lionnet A, Wade MA, Corbillé AG, Prigent A, Paillusson S, Tasselli M, Gonzales J, Durieu E, Rolli-Derkinderen M, Coron E, Duchalais E, Neunlist M, Perkinton MS, Hanger DP, Noble W, et al. Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy. Acta Neuropathologica Communications. 6: 65. PMID 30037345 DOI: 10.1186/S40478-018-0568-3  0.731
2018 Croft CL, Noble W. Preparation of organotypic brain slice cultures for the study of Alzheimer's disease. F1000research. 7: 592. PMID 29904599 DOI: 10.12688/F1000Research.14500.2  0.793
2018 Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JDH. A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathologica Communications. 6: 37. PMID 29730992 DOI: 10.1186/S40478-018-0539-8  0.786
2017 Croft CL, Kurbatskaya K, Hanger DP, Noble W. Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease. Scientific Reports. 7: 7434. PMID 28785087 DOI: 10.1038/S41598-017-07906-1  0.844
2017 Guo T, Noble W, Hanger DP. Roles of tau protein in health and disease. Acta Neuropathologica. PMID 28386764 DOI: 10.1007/s00401-017-1707-9  0.719
2017 Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ, Noble W, Hanger DP, Miller CC. α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production. Acta Neuropathologica. PMID 28337542 DOI: 10.1007/S00401-017-1704-Z  0.619
2017 Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS, Hanger DP, Noble W. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death & Disease. 8: e2671. PMID 28300838 DOI: 10.1038/Cddis.2017.97  0.841
2017 Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, et al. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. Plos Genetics. 13: e1006593. PMID 28253260 DOI: 10.1371/Journal.Pgen.1006593  0.499
2017 Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger DP, Miller CC. The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy. Current Biology : Cb. PMID 28132811 DOI: 10.1016/J.Cub.2016.12.038  0.572
2017 Hanger DP, Croft CL, Lau DH, Noble W. ACTIVITY-DEPENDENT TAU RELEASE: IMPLICATIONS FOR TAU PROPAGATION Alzheimer's & Dementia. 13: P888. DOI: 10.1016/J.Jalz.2017.07.288  0.818
2017 Giacomini C, Noble W, Hanger DP, Morris JD. [P1-223]: FUNCTIONAL ROLES FOR TAOK KINASES IN THE DEVELOPMENT OF TAU PATHOLOGY IN ALZHEIMER's DISEASE Alzheimer's & Dementia. 13: P328-P329. DOI: 10.1016/J.Jalz.2017.06.043  0.725
2016 Tiwari SS, Mizuno K, Ghosh A, Aziz W, Troakes C, Daoud J, Golash V, Noble W, Hortobágyi T, Giese KP. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain : a Journal of Neurology. PMID 27524794 DOI: 10.1093/Brain/Aww205  0.532
2016 Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE, Hanger DP, Noble W, Miller CC. ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations. Embo Reports. PMID 27418313 DOI: 10.15252/Embr.201541726  0.599
2016 Bondulich MK, Guo T, Meehan C, Manion J, Rodriguez Martin T, Mitchell JC, Hortobagyi T, Yankova N, Stygelbout V, Brion JP, Noble W, Hanger DP. Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. Brain : a Journal of Neurology. PMID 27297240 DOI: 10.1093/Brain/Aww137  0.732
2016 Lau DH, Hogseth M, Phillips EC, O'Neill MJ, Pooler AM, Noble W, Hanger DP. Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta Neuropathologica Communications. 4: 49. PMID 27193083 DOI: 10.1186/S40478-016-0317-4  0.776
2016 Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C, O'Neill MJ, Perez-Nievas BG, Hanger DP, Noble W. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathologica Communications. 4: 34. PMID 27036949 DOI: 10.1186/S40478-016-0299-2  0.822
2016 Hughes MM, Perez-Nievas BG, Troakes C, Perkinton M, Hanger DP, Noble W. Post-Mortem Brain Tissue Characterisation Of Inflammatory And Pathological Hallmarks Of Alzheimer’S Disease During Disease Progression Alzheimers & Dementia. 12: 462. DOI: 10.1016/J.Jalz.2016.06.903  0.399
2015 Tiwari SS, d'Orange M, Troakes C, Shurovi BN, Engmann O, Noble W, Hortobágyi T, Giese KP. Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease. Molecular Brain. 8: 6. PMID 25631211 DOI: 10.1186/S13041-015-0096-Z  0.472
2015 Croft CL, Hanger DP, Noble W. P3-054: The amyloid-binding agent bta-eg4 reduces pathological tau species in a novel organotypic 3xTg-AD brain slice culture model that recapitulates key in vivo degenerative phenotypes Alzheimer's & Dementia. 11: P639-P639. DOI: 10.1016/J.Jalz.2015.06.921  0.822
2014 Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W. Astrocytes and neuroinflammation in Alzheimer's disease. Biochemical Society Transactions. 42: 1321-5. PMID 25233410 DOI: 10.1042/Bst20140155  0.835
2014 Hanger DP, Lau DH, Phillips EC, Bondulich MK, Guo T, Woodward BW, Pooler AM, Noble W. Intracellular and extracellular roles for tau in neurodegenerative disease. Journal of Alzheimer's Disease : Jad. 40: S37-45. PMID 24595196 DOI: 10.3233/Jad-132054  0.755
2014 Pooler AM, Noble W, Hanger DP. A role for tau at the synapse in Alzheimer's disease pathogenesis. Neuropharmacology. 76: 1-8. PMID 24076336 DOI: 10.1016/J.Neuropharm.2013.09.018  0.73
2014 Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP, Noble W. Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease. Aging Cell. 13: 49-59. PMID 23919677 DOI: 10.1111/Acel.12148  0.819
2014 Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, Lin K, Breen G, Wroe R, To AW, Leroy K, ... ... Noble W, et al. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry. 19: 88-98. PMID 23164821 DOI: 10.1038/mp.2012.163  0.458
2014 Phillips EC, Garwood CJ, Hanger DP, Noble W. P1-116: ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY Alzheimer's & Dementia. 10: P343-P343. DOI: 10.1016/J.Jalz.2014.05.353  0.713
2014 Lau DH, Pooler AM, Noble W, Hanger DP. P1-115: IDENTIFICATION OF THE BINDING SITE BETWEEN TAU AND FYN: CONSEQUENCES FOR TAU RELEASE? Alzheimer's & Dementia. 10: P343-P343. DOI: 10.1016/J.Jalz.2014.05.352  0.6
2013 Noble W, Hanger DP, Miller CC, Lovestone S. The importance of tau phosphorylation for neurodegenerative diseases. Frontiers in Neurology. 4: 83. PMID 23847585 DOI: 10.3389/Fneur.2013.00083  0.775
2013 Vagnoni A, Glennon EB, Perkinton MS, Gray EH, Noble W, Miller CC. Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Human Molecular Genetics. 22: 4646-52. PMID 23825109 DOI: 10.1093/Hmg/Ddt313  0.431
2013 Rodríguez-Martín T, Cuchillo-Ibáñez I, Noble W, Nyenya F, Anderton BH, Hanger DP. Tau phosphorylation affects its axonal transport and degradation. Neurobiology of Aging. 34: 2146-57. PMID 23601672 DOI: 10.1016/J.Neurobiolaging.2013.03.015  0.748
2013 Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP, Morris JD. Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease. The Journal of Biological Chemistry. 288: 15418-29. PMID 23585562 DOI: 10.1074/Jbc.M112.448183  0.746
2013 Pooler AM, Phillips EC, Lau DH, Noble W, Hanger DP. Physiological release of endogenous tau is stimulated by neuronal activity. Embo Reports. 14: 389-94. PMID 23412472 DOI: 10.1038/Embor.2013.15  0.723
2013 Pooler A, Phillips E, Lau D, Noble W, Hanger D. O2-01-03: Neuronal activity regulates secretion of endogenous tau Alzheimer's & Dementia. 9: P314-P315. DOI: 10.1016/J.Jalz.2013.04.137  0.649
2012 Johnson R, Noble W, Tartaglia GG, Buckley NJ. Neurodegeneration as an RNA disorder. Progress in Neurobiology. 99: 293-315. PMID 23063563 DOI: 10.1016/J.Pneurobio.2012.09.006  0.345
2012 Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC. Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Human Molecular Genetics. 21: 2845-54. PMID 22434822 DOI: 10.1093/Hmg/Dds109  0.411
2012 Pooler AM, Usardi A, Evans CJ, Philpott KL, Noble W, Hanger DP. Dynamic association of tau with neuronal membranes is regulated by phosphorylation. Neurobiology of Aging. 33: 431.e27-38. PMID 21388709 DOI: 10.1016/J.Neurobiolaging.2011.01.005  0.704
2011 Noble W, Pooler AM, Hanger DP. Advances in tau-based drug discovery. Expert Opinion On Drug Discovery. 6: 797-810. PMID 22003359 DOI: 10.1517/17460441.2011.586690  0.736
2011 Hanger DP, Noble W. Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation. International Journal of Alzheimer's Disease. 2011: 352805. PMID 21776376 DOI: 10.4061/2011/352805  0.746
2011 Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R. Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. The Febs Journal. 278: 2927-37. PMID 21692989 DOI: 10.1111/J.1742-4658.2011.08218.X  0.737
2011 Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W. Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death & Disease. 2: e167. PMID 21633390 DOI: 10.1038/Cddis.2011.50  0.798
2010 Garwood CJ, Cooper JD, Hanger DP, Noble W. Anti-inflammatory impact of minocycline in a mouse model of tauopathy. Frontiers in Psychiatry. 1: 136. PMID 21423446 DOI: 10.3389/Fpsyt.2010.00136  0.815
2010 Noble W, Burns MP. Challenges in neurodegeneration research. Frontiers in Psychiatry. 1: 7. PMID 21423419 DOI: 10.3389/Fpsyt.2010.00007  0.647
2010 Noble W, Hanger DP, Gallo JM. Transgenic mouse models of tauopathy in drug discovery. Cns & Neurological Disorders Drug Targets. 9: 403-28. PMID 20522014 DOI: 10.2174/187152710791556131  0.707
2010 Garwood CJ, Hanger DP, Noble W. P1-315: Minocycline-mediated protection from Aβ is mediated primarily by suppression of astrocytic inflammatory responses Alzheimer's & Dementia. 6: S264-S265. DOI: 10.1016/J.Jalz.2010.05.868  0.739
2009 Hanger DP, Seereeram A, Noble W. Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert Review of Neurotherapeutics. 9: 1647-66. PMID 19903024 DOI: 10.1586/Ern.09.104  0.758
2009 Wray S, Noble W. Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9665-7. PMID 19657019 DOI: 10.1523/Jneurosci.2234-09.2009  0.687
2009 Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P. The microtubule-associated protein tau is also phosphorylated on tyrosine. Journal of Alzheimer's Disease : Jad. 18: 1-9. PMID 19542604 DOI: 10.3233/Jad-2009-1116  0.718
2009 Noble W, Garwood CJ, Hanger DP. Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding. Prion. 3: 78-83. PMID 19458490 DOI: 10.4161/Pri.3.2.8820  0.748
2009 Hanger DP, Anderton BH, Noble W. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends in Molecular Medicine. 15: 112-9. PMID 19246243 DOI: 10.1016/J.Molmed.2009.01.003  0.774
2009 Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH. Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 739-50. PMID 19001528 DOI: 10.1096/Fj.08-113795  0.834
2008 Noble W, Garwood C, Hanger DP, Anderton BH. P3-342: Amyloid-mediated NCX3 cleavage by calpain is an early and toxic event Alzheimer's & Dementia. 4: T622-T622. DOI: 10.1016/J.Jalz.2008.05.1911  0.745
2008 Garwood CJ, Anderton BH, Hanger DP, Noble W. P2-381: Minocycline reduces caspase-3 activation and prevents cleavage and aggregation of Tau in vivo Alzheimer's & Dementia. 4: T484-T484. DOI: 10.1016/J.Jalz.2008.05.1459  0.77
2007 Kelleher I, Garwood C, Hanger DP, Anderton BH, Noble W. Kinase activities increase during the development of tauopathy in htau mice. Journal of Neurochemistry. 103: 2256-67. PMID 17908241 DOI: 10.1111/J.1471-4159.2007.04930.X  0.812
2007 Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, et al. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of Neurochemistry. 103: 1132-44. PMID 17683481 DOI: 10.1111/J.1471-4159.2007.04829.X  0.795
2007 Gallo JM, Noble W, Martin TR. RNA and protein-dependent mechanisms in tauopathies: Consequences for therapeutic strategies Cellular and Molecular Life Sciences. 64: 1701-1714. PMID 17453144 DOI: 10.1007/S00018-007-6513-4  0.578
2006 Currais A, Malik B, Noble W, Towlson C, Soriano S. AbstractPoster presentation: Tuesday posterP3-410: Analysis of the role of presenilin 1 on tau homeostasis Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1681  0.471
2006 Noble W, Hanger DP, Anderton BH. O2-05-07: Minocycline reduces tau phosphorylation and protects against Aβ-induced neurotoxicity Alzheimer's & Dementia. 2: S41-S42. DOI: 10.1016/J.Jalz.2006.05.144  0.689
2005 Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. Journal of Cell Science. 118: 4645-54. PMID 16176937 DOI: 10.1242/jcs.02558  0.599
2005 Derkinderen P, Scales TM, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, Kellie S, Williamson R, Noble W, Van Etten RA, Leroy K, et al. Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6584-93. PMID 16014719 DOI: 10.1523/Jneurosci.1487-05.2005  0.724
2005 Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 6990-5. PMID 15867159 DOI: 10.1073/Pnas.0500466102  0.784
2004 Noble WJ, Utton MA, Anderton BH, Hanger DP. P3-258 Molecular motors implicated in the fast axonal transport of tau Neurobiology of Aging. 25: S428. DOI: 10.1016/S0197-4580(04)81408-8  0.554
2004 Noble WJ, Derkinderen P, Scales T, Price C, Bird IN, Kellie S, Varndell IM, Sheppard PW, Williamson R, Reynolds H, Anderton BH. P3-226 The microtubule-associated protein tau is phosphorylated on tyrosine 394 Neurobiology of Aging. 25: S419. DOI: 10.1016/S0197-4580(04)81376-9  0.355
2004 Williamson R, Noble W, Kinsey AM, Hye A, Anderton B. P1-293 Rapid lipid RAFT reorganisation and tyrosine phosphorylation of lipid RAFT components in response to amyloid-B peptide-treatment of primary neuronal cultures: involvement of FYN Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80606-7  0.375
2004 Duff K, Noble W. S3-01-01 Symposia session Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80151-9  0.447
2003 Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5645-9. PMID 12843267  0.72
2003 Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 38: 555-65. PMID 12765608 DOI: 10.1016/S0896-6273(03)00259-9  0.808
2003 Burns MP, Noble WJ, Olm V, Gaynor K, Casey E, LaFrancois J, Wang L, Duff K. Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques. Brain Research. Molecular Brain Research. 110: 119-25. PMID 12573540 DOI: 10.1016/S0169-328X(02)00647-2  0.7
2003 Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production In Vivo The Journal of Neuroscience. 23: 5645-5649. DOI: 10.1523/Jneurosci.23-13-05645.2003  0.69
2002 Duff K, Noble W, Gaynor K, Matsuoka Y. Organotypic slice cultures from transgenic mice as disease model systems. Journal of Molecular Neuroscience : Mn. 19: 317-20. PMID 12540058 DOI: 10.1385/Jmn:19:3:317  0.637
Low-probability matches (unlikely to be authored by this person)
2018 Pang CC, Kiecker C, O'Brien JT, Noble W, Chang RC. Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858418778747. PMID 29865938 DOI: 10.1177/1073858418778747  0.267
2022 Pang CCC, Sørensen MH, Lee K, Luk KC, Trojanowski JQ, Lee VMY, Noble W, Chang RCC. Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread. Neuropathology and Applied Neurobiology. e12829. PMID 35727707 DOI: 10.1111/nan.12829  0.232
2022 Martín-Guerrero SM, Markovinovic A, Mórotz GM, Salam S, Noble W, Miller CCJ. Targeting ER-Mitochondria Signaling as a Therapeutic Target for Frontotemporal Dementia and Related Amyotrophic Lateral Sclerosis. Frontiers in Cell and Developmental Biology. 10: 915931. PMID 35693938 DOI: 10.3389/fcell.2022.915931  0.216
1999 Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT. Long-term clinical efficacy of grass-pollen immunotherapy. The New England Journal of Medicine. 341: 468-75. PMID 10441602 DOI: 10.1056/Nejm199908123410702  0.212
2024 Markovinovic A, Martín-Guerrero SM, Mórotz GM, Salam S, Gomez-Suaga P, Paillusson S, Greig J, Lee Y, Mitchell JC, Noble W, Miller CCJ. Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca and synaptic defects. Acta Neuropathologica Communications. 12: 32. PMID 38395965 DOI: 10.1186/s40478-024-01742-x  0.204
2000 Nouri-Aria KT, O'Brien F, Noble W, Jabcobson MR, Rajakulasingam K, Durham SR. Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils Clinical and Experimental Allergy. 30: 1709-1716. PMID 11122208 DOI: 10.1046/J.1365-2222.2000.00998.X  0.202
2020 Derkinderen P, Noble W, Neunlist M, Rolli-Derkinderen M. Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson's disease. Gut. PMID 33203725 DOI: 10.1136/gutjnl-2020-323482  0.199
2022 Mórotz GM, Martín-Guerrero SM, Markovinovic A, Paillusson S, Russell MRG, Machado PMP, Fleck RA, Noble W, Miller CCJ. The PTPIP51 coiled-coil domain is important in VAPB binding, formation of ER-mitochondria contacts and IP3 receptor delivery of Ca to mitochondria. Frontiers in Cell and Developmental Biology. 10: 920947. PMID 36120587 DOI: 10.3389/fcell.2022.920947  0.171
2020 de Guilhem de Lataillade A, Lebouvier T, Noble W, Leclair-Visonneau L, Derkinderen P. Enteric synucleinopathy: from trendy concept to real entity. Free Neuropathology. 1. PMID 37283671 DOI: 10.17879/freeneuropathology-2020-2920  0.167
2019 Noble W, Spires-Jones TL. Sleep well to slow Alzheimer's progression? Science (New York, N.Y.). 363: 813-814. PMID 30792288 DOI: 10.1126/Science.Aaw5583  0.152
2015 Bailey TL, Johnson J, Grant CE, Noble WS. The MEME Suite. Nucleic Acids Research. PMID 25953851 DOI: 10.1093/Nar/Gkv416  0.124
2022 Hartopp N, Lau DHW, Martin-Guerrero SM, Markovinovic A, Mórotz GM, Greig J, Glennon EB, Troakes C, Gomez-Suaga P, Noble W, Miller CCJ. Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis. Frontiers in Cell and Developmental Biology. 10: 950767. PMID 36051435 DOI: 10.3389/fcell.2022.950767  0.123
2015 Gittelman RM, Hun E, Ay F, Madeoy J, Pennacchio L, Noble WS, Hawkins DR, Akey JM. Comprehensive identification and analysis of human accelerated regulatory DNA. Genome Research. PMID 26104583 DOI: 10.1101/Gr.192591.115  0.097
2012 Fioramonte M, dos Santos AM, McIlwain S, Noble WS, Franchini KG, Gozzo FC. Analysis of secondary structure in proteins by chemical cross-linking coupled to MS. Proteomics. 12: 2746-52. PMID 22778071 DOI: 10.1002/Pmic.201200040  0.09
2015 Ay F, Bunnik EM, Varoquaux N, Vert JP, Noble WS, Le Roch KG. Multiple dimensions of epigenetic gene regulation in the malaria parasite Plasmodium falciparum: gene regulation via histone modifications, nucleosome positioning and nuclear architecture in P. falciparum. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 182-94. PMID 25394267 DOI: 10.1002/Bies.201400145  0.089
2015 Riffle M, Merrihew GE, Jaschob D, Sharma V, Davis TN, Noble WS, MacCoss MJ. Visualization and Dissemination of Multidimensional Proteomics Data Comparing Protein Abundance During Caenorhabditis elegans Development. Journal of the American Society For Mass Spectrometry. PMID 26133526 DOI: 10.1007/S13361-015-1193-Z  0.082
2010 Agius P, Arvey A, Chang W, Noble WS, Leslie C. High resolution models of transcription factor-DNA affinities improve in vitro and in vivo binding predictions. Plos Computational Biology. 6. PMID 20838582 DOI: 10.1371/journal.pcbi.1000916  0.081
2010 Serang O, MacCoss MJ, Noble WS. Efficient marginalization to compute protein posterior probabilities from shotgun mass spectrometry data. Journal of Proteome Research. 9: 5346-57. PMID 20712337 DOI: 10.1021/Pr100594K  0.077
2010 Hue M, Riffle M, Vert JP, Noble WS. Large-scale prediction of protein-protein interactions from structures. Bmc Bioinformatics. 11: 144. PMID 20298601 DOI: 10.1186/1471-2105-11-144  0.075
2014 Ay F, Bunnik EM, Varoquaux N, Bol SM, Prudhomme J, Vert JP, Noble WS, Le Roch KG. Three-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene expression. Genome Research. 24: 974-88. PMID 24671853 DOI: 10.1101/Gr.169417.113  0.074
2014 Howbert JJ, Noble WS. Computing exact p-values for a cross-correlation shotgun proteomics score function. Molecular & Cellular Proteomics : McP. 13: 2467-79. PMID 24895379 DOI: 10.1074/mcp.O113.036327  0.072
2015 Berletch JB, Ma W, Yang F, Shendure J, Noble WS, Disteche CM, Deng X. Escape from X inactivation varies in mouse tissues. Plos Genetics. 11: e1005079. PMID 25785854 DOI: 10.1371/Journal.Pgen.1005079  0.072
2014 Sexton BS, Avey D, Druliner BR, Fincher JA, Vera DL, Grau DJ, Borowsky ML, Gupta S, Girimurugan SB, Chicken E, Zhang J, Noble WS, Zhu F, Kingston RE, Dennis JH. The spring-loaded genome: nucleosome redistributions are widespread, transient, and DNA-directed. Genome Research. 24: 251-9. PMID 24310001 DOI: 10.1101/Gr.160150.113  0.071
2012 Witten DM, Noble WS. On the assessment of statistical significance of three-dimensional colocalization of sets of genomic elements. Nucleic Acids Research. 40: 3849-55. PMID 22266657 DOI: 10.1093/nar/gks012  0.067
2012 Wang J, Zhuang J, Iyer S, Lin X, Whitfield TW, Greven MC, Pierce BG, Dong X, Kundaje A, Cheng Y, Rando OJ, Birney E, Myers RM, Noble WS, Snyder M, et al. Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Research. 22: 1798-812. PMID 22955990 DOI: 10.1101/Gr.139105.112  0.067
2014 Ay F, Bailey TL, Noble WS. Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts. Genome Research. 24: 999-1011. PMID 24501021 DOI: 10.1101/Gr.160374.113  0.066
2012 Cuellar-Partida G, Buske FA, McLeay RC, Whitington T, Noble WS, Bailey TL. Epigenetic priors for identifying active transcription factor binding sites. Bioinformatics (Oxford, England). 28: 56-62. PMID 22072382 DOI: 10.1093/bioinformatics/btr614  0.065
2011 Aydin Z, Singh A, Bilmes J, Noble WS. Learning sparse models for a dynamic Bayesian network classifier of protein secondary structure. Bmc Bioinformatics. 12: 154. PMID 21569525 DOI: 10.1186/1471-2105-12-154  0.065
2009 Klammer AA, Park CY, Noble WS. Statistical calibration of the SEQUEST XCorr function. Journal of Proteome Research. 8: 2106-13. PMID 19275164 DOI: 10.1021/Pr8011107  0.064
2015 Libbrecht MW, Ay F, Hoffman MM, Gilbert DM, Bilmes JA, Noble WS. Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression. Genome Research. 25: 544-57. PMID 25677182 DOI: 10.1101/Gr.184341.114  0.063
2009 Hesselberth JR, Chen X, Zhang Z, Sabo PJ, Sandstrom R, Reynolds AP, Thurman RE, Neph S, Kuehn MS, Noble WS, Fields S, Stamatoyannopoulos JA. Global mapping of protein-DNA interactions in vivo by digital genomic footprinting. Nature Methods. 6: 283-9. PMID 19305407 DOI: 10.1038/Nmeth.1313  0.063
2013 Zeitz MJ, Lerner PP, Ay F, Van Nostrand E, Heidmann JD, Noble WS, Hoffman AR. Implications of COMT long-range interactions on the phenotypic variability of 22q11.2 deletion syndrome. Nucleus (Austin, Tex.). 4: 487-93. PMID 24448439 DOI: 10.4161/Nucl.27364  0.063
2010 Hoffman MM, Buske OJ, Noble WS. The Genomedata format for storing large-scale functional genomics data. Bioinformatics (Oxford, England). 26: 1458-9. PMID 20435580 DOI: 10.1093/Bioinformatics/Btq164  0.062
2012 Spivak M, Weston J, Tomazela D, MacCoss MJ, Noble WS. Direct maximization of protein identifications from tandem mass spectra. Molecular & Cellular Proteomics : McP. 11: M111.012161. PMID 22052992 DOI: 10.1074/Mcp.M111.012161  0.062
2011 Granholm V, Noble WS, Käll L. On using samples of known protein content to assess the statistical calibration of scores assigned to peptide-spectrum matches in shotgun proteomics. Journal of Proteome Research. 10: 2671-8. PMID 21391616 DOI: 10.1021/pr1012619  0.061
2010 Sharma V, Eng JK, Feldman S, von Haller PD, MacCoss MJ, Noble WS. Precursor charge state prediction for electron transfer dissociation tandem mass spectra. Journal of Proteome Research. 9: 5438-44. PMID 20731383 DOI: 10.1021/Pr1006685  0.061
2013 Hoffman MM, Ernst J, Wilder SP, Kundaje A, Harris RS, Libbrecht M, Giardine B, Ellenbogen PM, Bilmes JA, Birney E, Hardison RC, Dunham I, Kellis M, Noble WS. Integrative annotation of chromatin elements from ENCODE data. Nucleic Acids Research. 41: 827-41. PMID 23221638 DOI: 10.1093/Nar/Gks1284  0.06
2014 Tyler R, Ji H, Perreau A, Witt S, Noble W, Coelho C. Development and validation of the tinnitus primary function questionnaire. American Journal of Audiology. 23: 260-72. PMID 24811293 DOI: 10.1044/2014_Aja-13-0014  0.06
2010 Chen X, Hoffman MM, Bilmes JA, Hesselberth JR, Noble WS. A dynamic Bayesian network for identifying protein-binding footprints from single molecule-based sequencing data. Bioinformatics (Oxford, England). 26: i334-42. PMID 20529925 DOI: 10.1093/Bioinformatics/Btq175  0.06
2011 Diament BJ, Noble WS. Faster SEQUEST searching for peptide identification from tandem mass spectra. Journal of Proteome Research. 10: 3871-9. PMID 21761931 DOI: 10.1021/Pr101196N  0.06
2012 Serang O, Noble WS. Faster mass spectrometry-based protein inference: junction trees are more efficient than sampling and marginalization by enumeration. Ieee/Acm Transactions On Computational Biology and Bioinformatics / Ieee, Acm. 9: 809-17. PMID 22331862 DOI: 10.1109/Tcbb.2012.26  0.059
2009 Hawkins J, Grant C, Noble WS, Bailey TL. Assessing phylogenetic motif models for predicting transcription factor binding sites. Bioinformatics (Oxford, England). 25: i339-47. PMID 19478008 DOI: 10.1093/Bioinformatics/Btp201  0.058
2015 Ay F, Noble WS. Analysis methods for studying the 3D architecture of the genome. Genome Biology. 16: 183. PMID 26328929 DOI: 10.1186/S13059-015-0745-7  0.058
2015 Varoquaux N, Liachko I, Ay F, Burton JN, Shendure J, Dunham MJ, Vert JP, Noble WS. Accurate identification of centromere locations in yeast genomes using Hi-C. Nucleic Acids Research. 43: 5331-9. PMID 25940625 DOI: 10.1093/Nar/Gkv424  0.057
2012 Di Rienzi SC, Lindstrom KC, Mann T, Noble WS, Raghuraman MK, Brewer BJ. Maintaining replication origins in the face of genomic change. Genome Research. 22: 1940-52. PMID 22665441 DOI: 10.1101/Gr.138248.112  0.057
2012 Singh AP, Halloran J, Bilmes JA, Kirchoff K, Noble WS. Spectrum Identification using a Dynamic Bayesian Network Model of Tandem Mass Spectra. Uncertainty in Artificial Intelligence : Proceedings of the ... Conference. Conference On Uncertainty in Artificial Intelligence. 28: 775-785. PMID 25383048  0.057
2015 Yardımcı GG, Noble WS. Predictive model of 3D domain formation via CTCF-mediated extrusion. Proceedings of the National Academy of Sciences of the United States of America. 112: 14404-5. PMID 26567152 DOI: 10.1073/Pnas.1519849112  0.057
2011 Hirsch E, Lim C, Dobrez D, Adams MG, Noble W. Meteorological factors and timing of the initiating event of human parturition. International Journal of Biometeorology. 55: 265-72. PMID 20526783 DOI: 10.1007/s00484-010-0332-2  0.055
2015 Aydin Z, Baker D, Noble WS. Template scoring methods for protein torsion angle prediction Communications in Computer and Information Science. 574: 206-223. DOI: 10.1007/978-3-319-27707-3_13  0.054
2014 Varoquaux N, Ay F, Noble WS, Vert JP. A statistical approach for inferring the 3D structure of the genome. Bioinformatics (Oxford, England). 30: i26-33. PMID 24931992 DOI: 10.1093/Bioinformatics/Btu268  0.054
2015 Ma W, Ay F, Lee C, Gulsoy G, Deng X, Cook S, Hesson J, Cavanaugh C, Ware CB, Krumm A, Shendure J, Blau CA, Disteche CM, Noble WS, Duan Z. Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes. Nature Methods. 12: 71-8. PMID 25437436 DOI: 10.1038/Nmeth.3205  0.054
2015 Ay F, Vu TH, Zeitz MJ, Varoquaux N, Carette JE, Vert JP, Hoffman AR, Noble WS. Identifying multi-locus chromatin contacts in human cells using tethered multiple 3C. Bmc Genomics. 16: 121. PMID 25887659 DOI: 10.1186/S12864-015-1236-7  0.053
2010 McIlwain S, Draghicescu P, Singh P, Goodlett DR, Noble WS. Detecting cross-linked peptides by searching against a database of cross-linked peptide pairs. Journal of Proteome Research. 9: 2488-95. PMID 20349954 DOI: 10.1021/Pr901163D  0.053
2011 Melvin I, Weston J, Noble WS, Leslie C. Detecting remote evolutionary relationships among proteins by large-scale semantic embedding. Plos Computational Biology. 7: e1001047. PMID 21298082 DOI: 10.1371/journal.pcbi.1001047  0.052
2009 Schutte NS, Noble W, Malouff JM, Bhullar N. Evaluation of a model of distress related to tinnitus. International Journal of Audiology. 48: 428-32. PMID 19925329 DOI: 10.1080/14992020802716786  0.052
2010 Aydin Z, Murray JI, Waterston RH, Noble WS. Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene expression in the developing C. elegans embryo. Bmc Bioinformatics. 11: 84. PMID 20146825 DOI: 10.1186/1471-2105-11-84  0.052
2012 McIlwain S, Mathews M, Bereman MS, Rubel EW, MacCoss MJ, Noble WS. Estimating relative abundances of proteins from shotgun proteomics data. Bmc Bioinformatics. 13: 308. PMID 23164367 DOI: 10.1186/1471-2105-13-308  0.051
2014 Ho JW, Jung YL, Liu T, Alver BH, Lee S, Ikegami K, Sohn KA, Minoda A, Tolstorukov MY, Appert A, Parker SC, Gu T, Kundaje A, Riddle NC, Bishop E, ... ... Noble WS, et al. Comparative analysis of metazoan chromatin organization. Nature. 512: 449-52. PMID 25164756 DOI: 10.1038/Nature13415  0.051
2015 Deng X, Ma W, Ramani V, Hill A, Yang F, Ay F, Berletch JB, Blau CA, Shendure J, Duan Z, Noble WS, Disteche CM. Bipartite structure of the inactive mouse X chromosome. Genome Biology. 16: 152. PMID 26248554 DOI: 10.1186/S13059-015-0728-8  0.05
2013 Zeitz MJ, Ay F, Heidmann JD, Lerner PL, Noble WS, Steelman BN, Hoffman AR. Genomic interaction profiles in breast cancer reveal altered chromatin architecture. Plos One. 8: e73974. PMID 24019942 DOI: 10.1371/Journal.Pone.0073974  0.05
2011 Harpenau LA, Noble WH, Kao RT. Diagnosis and management of dental wear. Journal of the California Dental Association. 39: 225-31. PMID 21675675  0.049
2015 Kertesz-Farkas A, Keich U, Noble WS. Tandem mass spectrum identification via cascaded search. Journal of Proteome Research. PMID 26084232 DOI: 10.1021/pr501173s  0.049
2012 Spivak M, Bereman MS, Maccoss MJ, Noble WS. Learning score function parameters for improved spectrum identification in tandem mass spectrometry experiments. Journal of Proteome Research. 11: 4499-508. PMID 22866926 DOI: 10.1021/Pr300234M  0.049
2010 Reynolds SM, Bilmes JA, Noble WS. Learning a weighted sequence model of the nucleosome core and linker yields more accurate predictions in Saccharomyces cerevisiae and Homo sapiens. Plos Computational Biology. 6: e1000834. PMID 20628623 DOI: 10.1371/Journal.Pcbi.1000834  0.049
2012 Qi Y, Oja M, Weston J, Noble WS. A unified multitask architecture for predicting local protein properties. Plos One. 7: e32235. PMID 22461885 DOI: 10.1371/Journal.Pone.0032235  0.048
2012 Arvey A, Agius P, Noble WS, Leslie C. Sequence and chromatin determinants of cell-type-specific transcription factor binding. Genome Research. 22: 1723-34. PMID 22955984 DOI: 10.1101/Gr.127712.111  0.048
2014 Ma W, Noble WS, Bailey TL. Motif-based analysis of large nucleotide data sets using MEME-ChIP. Nature Protocols. 9: 1428-50. PMID 24853928 DOI: 10.1038/nprot.2014.083  0.048
2010 Reynolds SM, Weng Z, Bilmes JA, Noble WS. Predicting nucleosome positioning using multiple evidence tracks Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 6044: 441-455. DOI: 10.1007/978-3-642-12683-3_29  0.047
2010 Duan Z, Andronescu M, Schutz K, McIlwain S, Kim YJ, Lee C, Shendure J, Fields S, Blau CA, Noble WS. A three-dimensional model of the yeast genome. Nature. 465: 363-7. PMID 20436457 DOI: 10.1038/Nature08973  0.046
2012 Ryu S, Goodlett DR, Noble WS, Minin VN. A statistical approach to peptide identification from clustered tandem mass spectrometry data. Proceedings. Ieee International Conference On Bioinformatics and Biomedicine. 648-653. PMID 23828149 DOI: 10.1109/BIBMW.2012.6470214  0.046
2009 Spivak M, Weston J, Bottou L, Käll L, Noble WS. Improvements to the percolator algorithm for Peptide identification from shotgun proteomics data sets. Journal of Proteome Research. 8: 3737-45. PMID 19385687 DOI: 10.1021/pr801109k  0.046
2015 Berletch JB, Ma W, Yang F, Shendure J, Noble WS, Disteche CM, Deng X. Identification of genes escaping X inactivation by allelic expression analysis in a novel hybrid mouse model Data in Brief. 5: 761-769. DOI: 10.1016/j.dib.2015.10.033  0.045
2011 Tanaka E, Bailey T, Grant CE, Noble WS, Keich U. Improved similarity scores for comparing motifs. Bioinformatics (Oxford, England). 27: 1603-9. PMID 21543443 DOI: 10.1093/Bioinformatics/Btr257  0.045
2013 Deng X, Berletch JB, Ma W, Nguyen DK, Hiatt JB, Noble WS, Shendure J, Disteche CM. Mammalian X upregulation is associated with enhanced transcription initiation, RNA half-life, and MOF-mediated H4K16 acetylation. Developmental Cell. 25: 55-68. PMID 23523075 DOI: 10.1016/J.Devcel.2013.01.028  0.045
2015 Yang F, Deng X, Ma W, Berletch JB, Rabaia N, Wei G, Moore JM, Filippova GN, Xu J, Liu Y, Noble WS, Shendure J, Disteche CM. The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation. Genome Biology. 16: 52. PMID 25887447 DOI: 10.1186/S13059-015-0618-0  0.045
2005 Gidiri M, Noble W, Rafique Z, Patil K, Lindow SW. Caesarean section for placenta praevia complicated by postpartum haemorrhage managed successfully with recombinant activated human coagulation Factor VIIa. Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology. 24: 925-6. PMID 16147656 DOI: 10.1080/01443610400019120  0.045
2015 Eng JK, Hoopmann MR, Jahan TA, Egertson JD, Noble WS, MacCoss MJ. A Deeper Look into Comet-Implementation and Features. Journal of the American Society For Mass Spectrometry. PMID 26115965 DOI: 10.1007/S13361-015-1179-X  0.044
2012 Hoffman MM, Buske OJ, Wang J, Weng Z, Bilmes JA, Noble WS. Unsupervised pattern discovery in human chromatin structure through genomic segmentation. Nature Methods. 9: 473-6. PMID 22426492 DOI: 10.1038/nmeth.1937  0.044
2009 Noble WS. A quick guide to organizing computational biology projects. Plos Computational Biology. 5: e1000424. PMID 19649301 DOI: 10.1371/journal.pcbi.1000424  0.043
2012 Duan Z, Andronescu M, Schutz K, Lee C, Shendure J, Fields S, Noble WS, Anthony Blau C. A genome-wide 3C-method for characterizing the three-dimensional architectures of genomes. Methods (San Diego, Calif.). 58: 277-88. PMID 22776363 DOI: 10.1016/J.Ymeth.2012.06.018  0.042
2015 Noble WS. Mass spectrometrists should search only for peptides they care about. Nature Methods. 12: 605-8. PMID 26125591 DOI: 10.1038/nmeth.3450  0.042
2012 Granholm V, Noble WS, Käll L. A cross-validation scheme for machine learning algorithms in shotgun proteomics. Bmc Bioinformatics. 13: S3. PMID 23176259 DOI: 10.1186/1471-2105-13-S16-S3  0.041
2009 Noble WS. How does multiple testing correction work? Nature Biotechnology. 27: 1135-7. PMID 20010596 DOI: 10.1038/nbt1209-1135  0.041
2013 Granholm V, Navarro JF, Noble WS, Käll L. Determining the calibration of confidence estimation procedures for unique peptides in shotgun proteomics. Journal of Proteomics. 80: 123-31. PMID 23268117 DOI: 10.1016/j.jprot.2012.12.007  0.041
2014 Zare H, Wang J, Hu A, Weber K, Smith J, Nickerson D, Song C, Witten D, Blau CA, Noble WS. Inferring clonal composition from multiple sections of a breast cancer. Plos Computational Biology. 10: e1003703. PMID 25010360 DOI: 10.1200/Jco.2014.32.15_Suppl.11077  0.041
2015 Dittmann S, Baring R, Baggalley S, Cantin A, Earl J, Gannon R, Keuning J, Mayo A, Navong N, Nelson M, Noble W, Ramsdale T. Drought and flood effects on macrobenthic communities in the estuary of Australia's largest river system Estuarine, Coastal and Shelf Science. 165: 36-51. DOI: 10.1016/j.ecss.2015.08.023  0.041
2015 Aydin Z, Baker D, Noble WS. Constructing structural profiles for protein torsion angle prediction Bioinformatics 2015 - 6th International Conference On Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference On Biomedical Engineering Systems and Technologies, Biostec 2015. 26-35.  0.041
2011 Buske OJ, Hoffman MM, Ponts N, Le Roch KG, Noble WS. Exploratory analysis of genomic segmentations with Segtools. Bmc Bioinformatics. 12: 415. PMID 22029426 DOI: 10.1186/1471-2105-12-415  0.04
2009 Bailey TL, Boden M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW, Noble WS. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Research. 37: W202-8. PMID 19458158 DOI: 10.1093/Nar/Gkp335  0.038
2011 Grant CE, Bailey TL, Noble WS. FIMO: scanning for occurrences of a given motif. Bioinformatics (Oxford, England). 27: 1017-8. PMID 21330290 DOI: 10.1093/Bioinformatics/Btr064  0.038
2012 Serang O, Noble W. A review of statistical methods for protein identification using tandem mass spectrometry Statistics and Its Interface. 5: 3-20.  0.038
2014 Halloran JT, Bilmes JA, Noble WS. Learning Peptide-Spectrum Alignment Models for Tandem Mass Spectrometry. Uncertainty in Artificial Intelligence : Proceedings of the ... Conference. Conference On Uncertainty in Artificial Intelligence. 30: 320-329. PMID 25298752  0.037
2015 Dileep V, Ay F, Sima J, Vera DL, Noble WS, Gilbert DM. Topologically associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication-timing program. Genome Research. PMID 25995270 DOI: 10.1101/Gr.183699.114  0.035
2009 Mann T, Humbert R, Dorschner M, Stamatoyannopoulos J, Noble WS. A thermodynamic approach to PCR primer design. Nucleic Acids Research. 37: e95. PMID 19528077 DOI: 10.1093/nar/gkp443  0.034
2010 Malouff JM, Noble W, Schutte NS, Bhullar N. The effectiveness of bibliotherapy in alleviating tinnitus-related distress. Journal of Psychosomatic Research. 68: 245-51. PMID 20159209 DOI: 10.1016/j.jpsychores.2009.07.023  0.034
2015 Beach EF, Noble W, Kitamura C. Modified spectral tilt affects infants' native-language discrimination of approximants and vowels. The Journal of the Acoustical Society of America. 138: EL352. PMID 26428839 DOI: 10.1121/1.4929732  0.032
2009 Käll L, Storey JD, Noble WS. QVALITY: non-parametric estimation of q-values and posterior error probabilities. Bioinformatics (Oxford, England). 25: 964-6. PMID 19193729 DOI: 10.1093/bioinformatics/btp021  0.031
2015 Keich U, Kertesz-Farkas A, Noble WS. Improved False Discovery Rate Estimation Procedure for Shotgun Proteomics. Journal of Proteome Research. 14: 3148-61. PMID 26152888 DOI: 10.1021/acs.jproteome.5b00081  0.03
2012 Tyler RS, Noble W, Coelho CB, Ji H. Tinnitus retraining therapy: mixing point and total masking are equally effective. Ear and Hearing. 33: 588-94. PMID 22609540 DOI: 10.1097/AUD.0b013e31824f2a6e  0.03
2015 Ting YS, Egertson JD, Payne SH, Kim S, MacLean B, Käll L, Aebersold RH, Smith RD, Noble WS, MacCoss MJ. Peptide-Centric Proteome Analysis: An Alternative Strategy for the Analysis of Tandem Mass Spectrometry Data. Molecular & Cellular Proteomics : McP. PMID 26217018 DOI: 10.1074/Mcp.O114.047035  0.03
2009 Noble W. Preventing the psychosocial risks of hearing loss. Australian Family Physician. 38: 591-3. PMID 19893780  0.03
2014 McIlwain S, Tamura K, Kertesz-Farkas A, Grant CE, Diament B, Frewen B, Howbert JJ, Hoopmann MR, Käll L, Eng JK, MacCoss MJ, Noble WS. Crux: rapid open source protein tandem mass spectrometry analysis. Journal of Proteome Research. 13: 4488-91. PMID 25182276 DOI: 10.1021/Pr500741Y  0.03
2011 Noble WH, Donovan TE, Geissberger M. Sports drinks and dental erosion. Journal of the California Dental Association. 39: 233-8. PMID 21675676  0.029
2012 Serang O, Noble W. A review of statistical methods for protein identification using tandem mass spectrometry. Statistics and Its Interface. 5: 3-20. PMID 22833779 DOI: 10.4310/Sii.2012.V5.N1.A2  0.029
2013 Skelly DA, Merrihew GE, Riffle M, Connelly CF, Kerr EO, Johansson M, Jaschob D, Graczyk B, Shulman NJ, Wakefield J, Cooper SJ, Fields S, Noble WS, Muller EG, Davis TN, et al. Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Research. 23: 1496-504. PMID 23720455 DOI: 10.1101/Gr.155762.113  0.028
2015 Keich U, Noble WS. On the importance of well-calibrated scores for identifying shotgun proteomics spectra. Journal of Proteome Research. 14: 1147-60. PMID 25482958 DOI: 10.1021/pr5010983  0.027
2014 Alaka KJ, Noble W, Montejo A, Dueñas H, Munshi A, Strawn JR, Lenox-Smith A, Ahl J, Bidzan L, Dorn B, Ball S. Efficacy and safety of duloxetine in the treatment of older adult patients with generalized anxiety disorder: a randomized, double-blind, placebo-controlled trial. International Journal of Geriatric Psychiatry. 29: 978-86. PMID 24644106 DOI: 10.1002/gps.4088  0.026
2012 Noble WS, MacCoss MJ. Computational and statistical analysis of protein mass spectrometry data. Plos Computational Biology. 8: e1002296. PMID 22291580 DOI: 10.1371/Journal.Pcbi.1002296  0.026
2012 McNeill C, Noble W, Purdy SC, O'Brien A, Sharma M. Bilateral cochlear implants in long-term and short-term deafness. Cochlear Implants International. 13: 50-3. PMID 22340752 DOI: 10.1179/146701011X13061407457704  0.022
2015 Libbrecht MW, Noble WS. Machine learning applications in genetics and genomics. Nature Reviews. Genetics. 16: 321-32. PMID 25948244 DOI: 10.1038/nrg3920  0.022
2015 Deng X, Ma W, Ramani V, Hill A, Yang F, Ay F, Berletch JB, Blau CA, Shendure J, Duan Z, Noble WS, Disteche CM. Bipartite structure of the inactive mouse X chromosome Genome Biology. 16. DOI: 10.1186/s13059-015-0728-8  0.021
2013 Croft C, Brown RF, Thorsteinsson EB, Noble W. Is tinnitus acceptance the same as tinnitus habituation? The International Tinnitus Journal. 18: 143-8. PMID 25773107 DOI: 10.5935/0946-5448.20130018  0.021
2013 Croft C, Brown RF, Thorsteinsson EB, Noble W. Development of the Tinnitus response scales: factor analyses, subscale reliability and validity analyses. The International Tinnitus Journal. 18: 45-56. PMID 24995899 DOI: 10.5935/0946-5448.20130007  0.016
2012 Noble WS, Blau CA, Dekker J, Duan ZJ, Mao Y. The structure and function of chromatin and chromosomes. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 434-40. PMID 22174298  0.015
2012 Harpenau LA, Noble WH, Kao RT. Diagnosis and management of dental wear. Today's Fda : Official Monthly Journal of the Florida Dental Association. 24: 50-7. PMID 23189508  0.015
2015 Noble WJ, Benkendorff K, Harris JO. Growth, settlement and survival of Dicathais orbita (Neogastropoda, Mollusca) larvae in response to temperature, diet and settlement cues Aquaculture Research. 46: 1455-1468. DOI: 10.1111/are.12298  0.014
2013 Galvin KL, Noble W. Adaptation of the speech, spatial, and qualities of hearing scale for use with children, parents, and teachers. Cochlear Implants International. 14: 135-41. PMID 23394704 DOI: 10.1179/1754762812Y.0000000014  0.014
2012 Anderson DL, Watt SE, Noble W, Shanley DC. Knowledge of attention deficit hyperactivity disorder (ADHD) and attitudes toward teaching children with ADHD: The role of teaching experience Psychology in the Schools. 49: 511-525. DOI: 10.1002/pits.21617  0.013
2013 Noble W, Jensen NS, Naylor G, Bhullar N, Akeroyd MA. A short form of the Speech, Spatial and Qualities of Hearing scale suitable for clinical use: the SSQ12. International Journal of Audiology. 52: 409-12. PMID 23651462 DOI: 10.3109/14992027.2013.781278  0.01
2012 Noble W, Naylor G, Bhullar N, Akeroyd MA. Self-assessed hearing abilities in middle- and older-age adults: a stratified sampling approach. International Journal of Audiology. 51: 174-80. PMID 22115161 DOI: 10.3109/14992027.2011.621899  0.01
2012 Kingery JE, Noble WG. Endometrial biopsy Osteopathic Family Physician. 4: 144-148. DOI: 10.1016/j.osfp.2012.05.002  0.01
2010 Noble W. Assessing binaural hearing: results using the speech, spatial and qualities of hearing scale. Journal of the American Academy of Audiology. 21: 568-74. PMID 21241644 DOI: 10.3766/jaaa.21.9.2  0.01
2010 Dunn CC, Noble W, Tyler RS, Kordus M, Gantz BJ, Ji H. Bilateral and unilateral cochlear implant users compared on speech perception in noise. Ear and Hearing. 31: 296-8. PMID 19858720 DOI: 10.1097/AUD.0b013e3181c12383  0.01
2009 Noble W, Tyler RS, Dunn CC, Bhullar N. Younger- and older-age adults with unilateral and bilateral cochlear implants: speech and spatial hearing self-ratings and performance. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 30: 921-9. PMID 19692936 DOI: 10.1097/MAO.0b013e3181b76b3b  0.01
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