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Robert Vassar - Publications

Northwestern University, Evanston, IL 

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cuddy LK, Prokopenko D, Cunningham EP, Brimberry R, Song P, Kirchner R, Chapman BA, Hofmann O, Hide W, Procissi D, Hanania T, Leiser SC, Tanzi RE, Vassar R. Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice. Science Translational Medicine. 12. PMID 32998969 DOI: 10.1126/scitranslmed.aaz2541  0.413
2020 Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Vassar R, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2  0.432
2020 Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, et al. The β-Secretase BACE1 in Alzheimer's Disease. Biological Psychiatry. PMID 32223911 DOI: 10.1016/J.Biopsych.2020.02.001  0.523
2020 Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y  0.517
2019 Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. The Journal of Experimental Medicine. PMID 30647119 DOI: 10.1084/Jem.20181035  0.475
2018 Ou-Yang MH, Kurz JE, Nomura T, Popovic J, Rajapaksha TW, Dong H, Contractor A, Chetkovich DM, Tourtellotte WG, Vassar R. Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Science Translational Medicine. 10. PMID 30232227 DOI: 10.1126/Scitranslmed.Aao5620  0.514
2018 Kukreja L, Shahidehpour R, Kim G, Keegan J, Sadleir KR, Russell T, Csernansky J, Mesulam M, Vassar RJ, Wang L, Dong H, Geula C. Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29807909 DOI: 10.1523/Jneurosci.1836-17.2018  0.591
2018 Stern AL, Ghura S, Gannon PJ, Akay-Espinoza C, Phan JM, Yee AC, Vassar R, Gelman BB, Kolson DL, Jordan-Sciutto KL. BACE1 mediates HIV-associated and excitotoxic neuronal damage through an APP-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29632166 DOI: 10.1523/Jneurosci.1280-17.2018  0.41
2017 Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. Plos Genetics. 13: e1006962. PMID 28806762 DOI: 10.1371/Journal.Pgen.1006962  0.483
2017 Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. APP mouse models for Alzheimer's disease preclinical studies. The Embo Journal. PMID 28768718 DOI: 10.15252/Embj.201797397  0.485
2017 Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. Journal of Alzheimer's Disease : Jad. PMID 28059792 DOI: 10.3233/Jad-161027  0.498
2017 Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, et al. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. The American Journal of Pathology. 187: 91-109. PMID 27993242 DOI: 10.1016/J.Ajpath.2016.09.006  0.415
2016 Iram T, Trudler D, Kain D, Kanner S, Galron R, Vassar R, Barzilai A, Blinder P, Fishelson Z, Frenkel D. Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection. Neurobiology of Disease. PMID 27544484 DOI: 10.1016/J.Nbd.2016.08.001  0.471
2016 Yan R, Fan Q, Zhou J, Vassar R. Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease. Neuroscience and Biobehavioral Reviews. PMID 27044452 DOI: 10.1016/J.Neubiorev.2016.03.025  0.453
2016 Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathologica. PMID 26993139 DOI: 10.1007/S00401-016-1558-9  0.541
2015 Liao F, Zhang TJ, Jiang H, Lefton KB, Robinson GO, Vassar R, Sullivan PM, Holtzman DM. Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models. Acta Neuropathologica Communications. 3: 70. PMID 26556230 DOI: 10.1186/S40478-015-0250-Y  0.465
2015 Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A. Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6544-53. PMID 25904804 DOI: 10.1523/Jneurosci.0314-14.2015  0.684
2015 Sadleir KR, Eimer WA, Cole SL, Vassar R. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Molecular Neurodegeneration. 10: 1. PMID 25567526 DOI: 10.1186/1750-1326-10-1  0.801
2014 Vassar R, Zheng H. Molecular neurodegeneration: basic biology and disease pathways. Molecular Neurodegeneration. 9: 34. PMID 25248568 DOI: 10.1186/1750-1326-9-34  0.308
2014 Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. Plos One. 9: e101643. PMID 24992504 DOI: 10.1371/Journal.Pone.0101643  0.812
2014 Kandalepas PC, Vassar R. The normal and pathologic roles of the Alzheimer's β-secretase, BACE1. Current Alzheimer Research. 11: 441-9. PMID 24893886 DOI: 10.2174/1567205011666140604122059  0.472
2014 Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Molecular Neurodegeneration. 9: 16. PMID 24885175 DOI: 10.1186/1750-1326-9-16  0.666
2014 Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/Jnc.12715  0.471
2014 Yan R, Vassar R. Targeting the β secretase BACE1 for Alzheimer's disease therapy. The Lancet. Neurology. 13: 319-29. PMID 24556009 DOI: 10.1016/S1474-4422(13)70276-X  0.395
2014 Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Molecular Neurodegeneration. 9: 1. PMID 24386896 DOI: 10.1186/1750-1326-9-1  0.698
2013 Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, ... ... Vassar R, et al. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Reports. 5: 1552-63. PMID 24373286 DOI: 10.1016/J.Celrep.2013.12.006  0.443
2013 Sadleir KR, Bennett DA, Schneider JA, Vassar R. Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis. Current Alzheimer Research. 10: 785-9. PMID 23919773 DOI: 10.2174/15672050113109990152  0.399
2013 Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathologica. 126: 329-52. PMID 23820808 DOI: 10.1007/S00401-013-1152-3  0.813
2013 Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/J.Ajpath.2013.05.005  0.34
2013 Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-f. PMID 23704555 DOI: 10.1126/Science.1235505  0.449
2013 Eimer WA, Vassar R. Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation. Molecular Neurodegeneration. 8: 2. PMID 23316765 DOI: 10.1186/1750-1326-8-2  0.79
2013 Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Udayar V, Elie A, Lefkow M, Roseman J, Meckler X, Bhattacharyya S, George M, Waters J, Bindokas VP, Parent AT, Rajendran L, ... ... Vassar R, et al. Regulation of dynamic BACE1 trafficking in neurons Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O8  0.696
2013 Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. Erratum to: The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques Acta Neuropathologica. 126: 623-623. DOI: 10.1007/S00401-013-1176-8  0.768
2012 Perez SE, Nadeem M, Sadleir KR, Matras J, Kelley CM, Counts SE, Vassar R, Mufson EJ. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. International Journal of Physiology, Pathophysiology and Pharmacology. 4: 115-27. PMID 23071869  0.412
2012 Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R. β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. The Journal of Biological Chemistry. 287: 38408-25. PMID 22988240 DOI: 10.1074/Jbc.M112.415505  0.748
2012 Kandalepas PC, Vassar R. Identification and biology of β-secretase. Journal of Neurochemistry. 120: 55-61. PMID 22122287 DOI: 10.1111/j.1471-4159.2011.07512.x  0.509
2011 Rajapaksha TW, Eimer WA, Bozza TC, Vassar R. The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb. Molecular Neurodegeneration. 6: 88. PMID 22204380 DOI: 10.1186/1750-1326-6-88  0.798
2011 Zhao J, O'Connor T, Vassar R. The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis. Journal of Neuroinflammation. 8: 150. PMID 22047170 DOI: 10.1186/1742-2094-8-150  0.436
2011 Vassar R, Kandalepas PC. The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease. Alzheimer's Research & Therapy. 3: 20. PMID 21639952 DOI: 10.1186/alzrt82  0.476
2011 Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M. Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. Plos One. 6: e16564. PMID 21305046 DOI: 10.1371/Journal.Pone.0016564  0.462
2011 Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods. 196: 51-9. PMID 21219931 DOI: 10.1016/J.Jneumeth.2010.12.025  0.432
2011 Kaczorowski CC, Sametsky E, Shah S, Vassar R, Disterhoft JF. Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease. Neurobiology of Aging. 32: 1452-65. PMID 19833411 DOI: 10.1016/J.Neurobiolaging.2009.09.003  0.721
2010 Hitt BD, Jaramillo TC, Chetkovich DM, Vassar R. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Molecular Neurodegeneration. 5: 31. PMID 20731874 DOI: 10.1186/1750-1326-5-31  0.786
2010 Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiology of Aging. 31: 1690-9. PMID 19022536 DOI: 10.1016/J.Neurobiolaging.2008.09.019  0.399
2009 Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12787-94. PMID 19828790 DOI: 10.1523/Jneurosci.3657-09.2009  0.478
2009 Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/Jbc.M808920200  0.428
2009 Cole SL, Vassar R. Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1. Neurobiology of Aging. 30: 1535-44. PMID 18289733 DOI: 10.1016/j.neurobiolaging.2007.12.012  0.452
2008 O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, ... Vassar R, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/J.Neuron.2008.10.047  0.77
2008 Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. The Journal of Biological Chemistry. 283: 35763-71. PMID 18845544 DOI: 10.1074/Jbc.M801353200  0.439
2008 Cole SL, Vassar R. The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology. The Journal of Biological Chemistry. 283: 29621-5. PMID 18650431 DOI: 10.1074/jbc.R800015200  0.516
2008 Cole SL, Vassar R. BACE1 structure and function in health and Alzheimer's disease. Current Alzheimer Research. 5: 100-20. PMID 18393796 DOI: 10.2174/156720508783954758  0.511
2007 Cole SL, Vassar R. The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease. Current Genomics. 8: 509-30. PMID 19415126 DOI: 10.2174/138920207783769512  0.495
2007 Cole SL, Vassar R. The Alzheimer's disease beta-secretase enzyme, BACE1. Molecular Neurodegeneration. 2: 22. PMID 18005427 DOI: 10.1186/1750-1326-2-22  0.487
2007 Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 104: 8167-72. PMID 17470798 DOI: 10.1073/Pnas.0609521104  0.446
2007 Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3639-49. PMID 17409228 DOI: 10.1523/Jneurosci.4396-06.2007  0.817
2007 Ohno M, Cole SL, Yasvoina M, Zhao J, Citron M, Berry R, Disterhoft JF, Vassar R. BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiology of Disease. 26: 134-45. PMID 17258906 DOI: 10.1016/J.Nbd.2006.12.008  0.542
2006 Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10129-40. PMID 17021169 DOI: 10.1523/JNEUROSCI.1202-06.2006  0.548
2006 Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. The European Journal of Neuroscience. 23: 251-60. PMID 16420434 DOI: 10.1111/j.1460-9568.2005.04551.x  0.482
2006 Cole SL, Vassar R. Isoprenoids and Alzheimer's disease: a complex relationship. Neurobiology of Disease. 22: 209-22. PMID 16406223 DOI: 10.1016/j.nbd.2005.11.007  0.427
2006 Vassar R, Oakley H, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R. O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer's disease mutations Alzheimer's & Dementia. 2: S88-S88. DOI: 10.1016/j.jalz.2006.05.339  0.472
2005 Kelly BL, Vassar R, Ferreira A. Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. The Journal of Biological Chemistry. 280: 31746-53. PMID 16002400 DOI: 10.1074/Jbc.M503259200  0.486
2005 Cole SL, Grudzien A, Manhart IO, Kelly BL, Oakley H, Vassar R. Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism. The Journal of Biological Chemistry. 280: 18755-70. PMID 15718241 DOI: 10.1074/Jbc.M413895200  0.384
2004 Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 41: 27-33. PMID 14715132 DOI: 10.1016/S0896-6273(03)00810-9  0.53
2004 Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. P2-037 Genetic evidence for therapeutic inhibition of BACE1 in an Alzheimer's mouse model Neurobiology of Aging. 25: S234. DOI: 10.1016/S0197-4580(04)80784-X  0.355
2003 Luo Y, Bolon B, Damore MA, Fitzpatrick D, Liu H, Zhang J, Yan Q, Vassar R, Citron M. BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiology of Disease. 14: 81-8. PMID 13678669 DOI: 10.1016/S0969-9961(03)00104-9  0.491
2003 Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7504-9. PMID 12930788  0.393
2003 Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease The Journal of Neuroscience. 23: 7504-7509. DOI: 10.1523/Jneurosci.23-20-07504.2003  0.489
2002 Estus S, Borchelt D, Kindy MS, Vassar R. Abeta deposition is essential to AD neuropathology. Journal of Alzheimer's Disease : Jad. 4: 133-8. PMID 12226531 DOI: 10.3233/Jad-2002-4302  0.422
2001 Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, ... Vassar R, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nature Neuroscience. 4: 231-2. PMID 11224535 DOI: 10.1038/85059  0.453
2000 Vassar R, Citron M. Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron. 27: 419-22. PMID 11055423 DOI: 10.1016/S0896-6273(00)00051-9  0.339
2000 Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase. The Journal of Biological Chemistry. 275: 37712-7. PMID 10956649 DOI: 10.1074/Jbc.M005339200  0.412
1996 Mombaerts P, Wang F, Dulac C, Vassar R, Chao SK, Nemes A, Mendelsohn M, Edmondson J, Axel R. The molecular biology of olfactory perception. Cold Spring Harbor Symposia On Quantitative Biology. 61: 135-45. PMID 9246442 DOI: 10.1101/Sqb.1996.061.01.016  0.742
1995 Fülle HJ, Vassar R, Foster DC, Yang RB, Axel R, Garbers DL. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 3571-5. PMID 7724600 DOI: 10.1073/Pnas.92.8.3571  0.572
1994 Vassar R, Chao SK, Sitcheran R, Nuñez JM, Vosshall LB, Axel R. Topographic organization of sensory projections to the olfactory bulb. Cell. 79: 981-91. PMID 8001145 DOI: 10.1016/0092-8674(94)90029-9  0.71
1993 Vassar R, Ngai J, Axel R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell. 74: 309-18. PMID 8343958 DOI: 10.1016/0092-8674(93)90422-M  0.666
1991 Coulombe PA, Hutton ME, Vassar R, Fuchs E. A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. The Journal of Cell Biology. 115: 1661-74. PMID 1721910 DOI: 10.1083/Jcb.115.6.1661  0.351
1991 Vassar R, Coulombe PA, Degenstein L, Albers K, Fuchs E. Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell. 64: 365-80. PMID 1703046 DOI: 10.1016/0092-8674(91)90645-F  0.352
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