| Year |
Citation |
Score |
| 2024 |
Elezaby A, Lin AJ, Vijayan V, Pokhrel S, Kraemer BR, Bechara LRG, Larus I, Sun J, Baena V, Syed ZA, Murphy E, Glancy B, Ostberg NP, Queliconi BB, Campos JC, ... ... Mochly-Rosen D, et al. Cardiac troponin I directly binds and inhibits mitochondrial ATP synthase with a noncanonical role in the post-ischemic heart. Nature Cardiovascular Research. 3: 987-1002. PMID 39196031 DOI: 10.1038/s44161-024-00512-1 |
0.306 |
|
| 2024 |
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D. Author Correction: A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nature Communications. 15: 2889. PMID 38570501 DOI: 10.1038/s41467-024-47288-3 |
0.347 |
|
| 2023 |
Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D. Corrigendum to "Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy" [Journal: Molecular of and Cellular Cardiology (2019) May 130;160-169]. Journal of Molecular and Cellular Cardiology. PMID 38000978 DOI: 10.1016/j.yjmcc.2023.11.004 |
0.441 |
|
| 2022 |
Frumkin LR, Lucas M, Scribner CL, Ortega-Heinly N, Rogers J, Yin G, Hallam TJ, Yam A, Bedard K, Begley R, Cohen CA, Badger CV, Abbasi SA, Dye JM, McMillan B, ... ... Mochly-Rosen D, et al. Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19. Frontiers in Immunology. 13: 899617. PMID 35720389 DOI: 10.3389/fimmu.2022.899617 |
0.745 |
|
| 2022 |
Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D. A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury. Pharmaceuticals (Basel, Switzerland). 15. PMID 35337069 DOI: 10.3390/ph15030271 |
0.32 |
|
| 2022 |
Mukherjee R, Tompkins CA, Ostberg NP, Joshi AU, Massis LM, Vijayan V, Gera K, Monack D, Cornell TT, Hall MW, Mochly-Rosen D, Haileselassie B. Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance. Critical Care Medicine. PMID 35067534 DOI: 10.1097/CCM.0000000000005437 |
0.432 |
|
| 2021 |
Lin AJ, Joshi AU, Mukherjee R, Tompkins CA, Vijayan V, Mochly-Rosen D, Haileselassie B. δPKC-Mediated Drp1 Phosphorylation Impacts Macrophage Mitochondrial Function and Inflammatory Response to Endotoxin. Shock (Augusta, Ga.). PMID 34738957 DOI: 10.1097/SHK.0000000000001885 |
0.425 |
|
| 2021 |
Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, ... ... Mochly-Rosen D, et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. PMID 33473210 DOI: 10.1038/s41586-020-03160-0 |
0.386 |
|
| 2020 |
Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D. Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience. PMID 33324000 DOI: 10.1038/s41593-020-00774-5 |
0.372 |
|
| 2020 |
Chen CH, Ferreira JCB, Joshi AU, Stevens MC, Li SJ, Hsu JH, Maclean R, Ferreira ND, Cervantes PR, Martinez DD, Barrientos FL, Quintanares GHR, Mochly-Rosen D. Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity. Ebiomedicine. 55: 102753. PMID 32403082 DOI: 10.1016/J.Ebiom.2020.102753 |
0.574 |
|
| 2020 |
Haileselassie B, Joshi AU, Minhas PS, Mukherjee R, Andreasson KI, Mochly-Rosen D. Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy. Journal of Neuroinflammation. 17: 36. PMID 31987040 DOI: 10.1186/S12974-019-1689-8 |
0.517 |
|
| 2020 |
Haileselassie B, Joshi A, Minhas P, Andreasson K, Mochly-Rosen D. 1693 Critical Care Medicine. 48: 821. DOI: 10.1097/01.Ccm.0000648672.84703.Fc |
0.473 |
|
| 2019 |
Joshi AU, Van Wassenhove LD, Logas KR, Minhas PS, Andreasson KI, Weinberg KI, Chen CH, Mochly-Rosen D. Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology. Acta Neuropathologica Communications. 7: 190. PMID 31829281 DOI: 10.1186/S40478-019-0839-7 |
0.477 |
|
| 2019 |
Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, ... ... Mochly-Rosen D, et al. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 140: 1205-1216. PMID 31769940 DOI: 10.1161/Circulationaha.119.040551 |
0.315 |
|
| 2019 |
Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D. Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience. 22: 1635-1648. PMID 31551592 DOI: 10.1038/S41593-019-0486-0 |
0.499 |
|
| 2019 |
Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D. Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 30981733 DOI: 10.1016/J.Yjmcc.2019.04.006 |
0.519 |
|
| 2019 |
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D. A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nature Communications. 10: 329. PMID 30659190 DOI: 10.1038/S41467-018-08276-6 |
0.539 |
|
| 2019 |
Tsai J, Logas KR, Van Wassenhove LD, Dejene B, Chen C, Mochly-Rosen D, Weinberg KI. Pharmacologic Activation of Aldehyde Metabolism to Protect Hematopoietic Stem Cells (HSC) in Murine Models of Fanconi Anemia (FA) Blood. 134: 105-105. DOI: 10.1182/Blood-2019-124439 |
0.306 |
|
| 2019 |
Haileselassie B, Joshi A, Mukherjee R, Napier BN, Massis L, Ostberg N, Monack D, Bernstein D, Mochly-Rosen D. 41 Critical Care Medicine. 47: 21. DOI: 10.1097/01.Ccm.0000550833.50487.Ba |
0.473 |
|
| 2018 |
Joshi AU, Ebert AE, Haileselassie B, Mochly-Rosen D. Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease. Journal of Molecular and Cellular Cardiology. 127: 125-133. PMID 30550751 DOI: 10.1016/J.Yjmcc.2018.12.004 |
0.521 |
|
| 2018 |
Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, et al. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nature Immunology. PMID 30478397 DOI: 10.1038/S41590-018-0255-3 |
0.473 |
|
| 2018 |
Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D. Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. Scientific Reports. 8: 14034. PMID 30232469 DOI: 10.1038/S41598-018-32228-1 |
0.316 |
|
| 2018 |
Kiyuna LA, Prestes E Albuquerque R, Chen CH, Mochly-Rosen D, Ferreira JCB. Targeting mitochondrial dysfunction and oxidative stress in heart failure: challenges and opportunities. Free Radical Biology & Medicine. PMID 30227272 DOI: 10.1016/J.Freeradbiomed.2018.09.019 |
0.33 |
|
| 2018 |
Joshi AU, Mochly-Rosen D. Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases. Pharmacological Research. PMID 30144530 DOI: 10.1016/J.Phrs.2018.08.010 |
0.52 |
|
| 2018 |
Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, ... ... Mochly-Rosen D, et al. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29794221 DOI: 10.1073/Pnas.1802184115 |
0.487 |
|
| 2018 |
Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW. MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science (New York, N.Y.). 360: 336-341. PMID 29674596 DOI: 10.1126/Science.Aao1785 |
0.334 |
|
| 2018 |
Ueta CB, Campos JC, Albuquerque RPE, Lima VM, Disatnik MH, Sanchez AB, Chen CH, Medeiros MHG, Yang W, Mochly-Rosen D, Ferreira JCB. Cardioprotection induced by a brief exposure to acetaldehyde:role of aldehyde dehydrogenase 2. Cardiovascular Research. PMID 29579152 DOI: 10.1093/Cvr/Cvy070 |
0.312 |
|
| 2018 |
Joshi AU, Saw NL, Shamloo M, Mochly-Rosen D. Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease. Oncotarget. 9: 6128-6143. PMID 29464060 DOI: 10.18632/Oncotarget.23640 |
0.504 |
|
| 2018 |
Deshwal S, Forkink M, Hu CH, Buonincontri G, Antonucci S, Di Sante M, Murphy MP, Paolocci N, Mochly-Rosen D, Krieg T, Di Lisa F, Kaludercic N. Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes. Cell Death and Differentiation. PMID 29459772 DOI: 10.1038/S41418-018-0071-1 |
0.349 |
|
| 2018 |
Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D. Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis. Embo Molecular Medicine. PMID 29335339 DOI: 10.15252/Emmm.201708166 |
0.447 |
|
| 2018 |
Chandramouleeswaran PM, Whelan KA, Engel N, Correnti J, Tanaka K, Srinivasan S, Guha M, Carr R, Klein-Szanto AJ, Kalyanaraman B, Chen C, Mochly-Rosen D, Avadhani NG, Nakagawa H. Abstract 5061: ALDH2 restricts esophageal stem/progenitor cell expansion via autophagy under alcohol-induced mitochondrial stress Cancer Research. 78: 5061-5061. DOI: 10.1158/1538-7445.Am2018-5061 |
0.333 |
|
| 2018 |
Haileselassie B, Joshi A, Bernstein D, Mochly-Rosen D. 1517 Critical Care Medicine. 46: 742. DOI: 10.1097/01.Ccm.0000529519.11903.9B |
0.473 |
|
| 2018 |
Kiyuna L, MacRae IJ, Chen C, Mochly-Rosen D, Ferreira JC. 4-HNE-mediated post-translational modulation of DICER in heart failure Free Radical Biology and Medicine. 128: S29. DOI: 10.1016/J.Freeradbiomed.2018.10.026 |
0.382 |
|
| 2017 |
Kim J, Shin JH, Chen CH, Cruz L, Farnebo L, Yang J, Borges P, Kang G, Mochly-Rosen D, Sunwoo JB. Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor. Oncotarget. 8: 52345-52356. PMID 28881734 DOI: 10.18632/Oncotarget.17017 |
0.308 |
|
| 2017 |
Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. Autophagy. 0. PMID 28598232 DOI: 10.1080/15548627.2017.1325062 |
0.359 |
|
| 2017 |
Qvit N, Kornfeld OS, Mochly-Rosen D. Corrigendum: Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics. Angewandte Chemie (International Ed. in English). 56: 2236. PMID 28194928 DOI: 10.1002/Anie.201700072 |
0.315 |
|
| 2017 |
Cunningham AD, Qvit N, Mochly-Rosen D. Peptides and peptidomimetics as regulators of protein-protein interactions. Current Opinion in Structural Biology. 44: 59-66. PMID 28063303 DOI: 10.1016/J.Sbi.2016.12.009 |
0.353 |
|
| 2017 |
Nene A, Chen CH, Disatnik MH, Cruz L, Mochly-Rosen D. Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites. Journal of Biomedical Science. 24: 3. PMID 28056995 DOI: 10.1186/S12929-016-0312-X |
0.385 |
|
| 2016 |
Chen CH, Joshi AU, Mochly-Rosen D. The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration. Acta Neurologica Taiwanica. 25: 111-123. PMID 28382610 |
0.438 |
|
| 2016 |
Disatnik MH, Joshi AU, Saw NL, Shamloo M, Leavitt BR, Qi X, Mochly-Rosen D. Potential biomarkers to follow the progression and treatment response of Huntington's disease. The Journal of Experimental Medicine. PMID 27821553 DOI: 10.1084/Jem.20160776 |
0.56 |
|
| 2016 |
Yu YH, Liao PR, Guo CJ, Chen CH, Mochly-Rosen D, Chuang LM. PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation. Plos One. 11: e0161993. PMID 27575855 DOI: 10.1371/Journal.Pone.0161993 |
0.34 |
|
| 2016 |
Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nature Communications. 7: 12646. PMID 27561680 DOI: 10.1038/Ncomms12646 |
0.605 |
|
| 2016 |
Qvit N, Disatnik MH, Sho J, Mochly-Rosen D. Selective phosphorylation inhibitor of δPKC-PDK protein-protein inter-actions; application for myocardial injury in vivo. Journal of the American Chemical Society. PMID 27218445 DOI: 10.1021/Jacs.6B02724 |
0.408 |
|
| 2016 |
Joshi AU, Kornfeld OS, Mochly-Rosen D. The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained. Cell Calcium. PMID 27212603 DOI: 10.1016/J.Ceca.2016.04.010 |
0.516 |
|
| 2016 |
Qvit N, Joshi AU, Cunningham AD, Ferreira JC, Mochly-Rosen D. GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death. The Journal of Biological Chemistry. PMID 27129213 DOI: 10.1074/Jbc.M115.711630 |
0.595 |
|
| 2016 |
Qvit N, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang LA, Baron LA, Teh-Poot C, Martínez-Vega P, Ramirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, ... ... Mochly-Rosen D, et al. Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors. International Journal For Parasitology. Drugs and Drug Resistance. 6: 74-84. PMID 27054066 DOI: 10.1016/J.Ijpddr.2016.02.003 |
0.354 |
|
| 2015 |
Hwang S, Disatnik MH, Mochly-Rosen D. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. Embo Molecular Medicine. 7: 1307-26. PMID 26268247 DOI: 10.15252/Emmm.201505256 |
0.336 |
|
| 2015 |
Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D. Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases. Circulation Research. 116: 1783-99. PMID 25999419 DOI: 10.1161/Circresaha.116.305432 |
0.301 |
|
| 2015 |
Disatnik MH, Hwang S, Ferreira JC, Mochly-Rosen D. New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases. Journal of Molecular Medicine (Berlin, Germany). 93: 279-87. PMID 25652199 DOI: 10.1007/S00109-015-1256-4 |
0.345 |
|
| 2015 |
Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. International Journal of Cardiology. 179: 129-38. PMID 25464432 DOI: 10.1016/J.Ijcard.2014.10.140 |
0.355 |
|
| 2015 |
Chiu CC, Yeh TH, Lai SC, Wu-Chou YH, Chen CH, Mochly-Rosen D, Huang YC, Chen YJ, Chen CL, Chang YM, Wang HL, Lu CS. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental Neurology. 263: 244-53. PMID 25263579 DOI: 10.1016/J.Expneurol.2014.09.016 |
0.354 |
|
| 2014 |
Qvit N, Mochly-Rosen D. The many hats of protein kinase Cδ: one enzyme with many functions. Biochemical Society Transactions. 42: 1529-33. PMID 25399565 DOI: 10.1042/Bst20140189 |
0.372 |
|
| 2014 |
Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine. 6: 255ra130. PMID 25253673 DOI: 10.1126/Scitranslmed.3009027 |
0.359 |
|
| 2014 |
Mochly-Rosen D, Disatnik MH, Qi X. The challenge in translating basic research discoveries to treatment of Huntington disease. Rare Diseases (Austin, Tex.). 2: e28637. PMID 25054095 DOI: 10.4161/rdis.28637 |
0.304 |
|
| 2014 |
Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling. Cardiovascular Research. 103: 498-508. PMID 24817685 DOI: 10.1093/Cvr/Cvu125 |
0.374 |
|
| 2014 |
Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. Journal of Medicinal Chemistry. 57: 714-22. PMID 24444054 DOI: 10.1021/Jm401377V |
0.306 |
|
| 2014 |
Qvit N, Disatnik M, Mochly-Rosen D. Engineering a delta protein kinase C inhibitor that selectively inhibits interaction and phosphorylation of one substrate of the multi-substrate kinase (582.3) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.582.3 |
0.438 |
|
| 2013 |
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X. Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. The Journal of Clinical Investigation. 123: 5371-88. PMID 24231356 DOI: 10.1172/Jci70911 |
0.467 |
|
| 2013 |
Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D. Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. Journal of the American Heart Association. 2: e000461. PMID 24103571 DOI: 10.1161/Jaha.113.000461 |
0.494 |
|
| 2013 |
Gross ER, Hsu AK, Urban TJ, Mochly-Rosen D, Gross GJ. Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C. Basic Research in Cardiology. 108: 381. PMID 23982492 DOI: 10.1007/S00395-013-0381-X |
0.376 |
|
| 2013 |
Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury. The Journal of Biological Chemistry. 288: 18947-60. PMID 23653351 DOI: 10.1074/Jbc.M113.466870 |
0.409 |
|
| 2013 |
Solito R, Corti F, Chen CH, Mochly-Rosen D, Giachetti A, Ziche M, Donnini S. Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis. Journal of Cell Science. 126: 1952-61. PMID 23447675 DOI: 10.1242/Jcs.117184 |
0.352 |
|
| 2013 |
Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG. Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice. Journal of Neuroscience Research. 91: 799-807. PMID 23426889 DOI: 10.1002/Jnr.23186 |
0.437 |
|
| 2013 |
Qi X, Qvit N, Su YC, Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. Journal of Cell Science. 126: 789-802. PMID 23239023 DOI: 10.1242/Jcs.114439 |
0.462 |
|
| 2013 |
Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate. Nmr in Biomedicine. 26: 607-12. PMID 23225495 DOI: 10.1002/Nbm.2897 |
0.312 |
|
| 2012 |
Campos JC, Queliconi BB, Dourado PM, Cunha TF, Zambelli VO, Bechara LR, Kowaltowski AJ, Brum PC, Mochly-Rosen D, Ferreira JC. Exercise training restores cardiac protein quality control in heart failure. Plos One. 7: e52764. PMID 23300764 DOI: 10.1371/Journal.Pone.0052764 |
0.369 |
|
| 2012 |
Mochly-Rosen D, Das K, Grimes KV. Protein kinase C, an elusive therapeutic target? Nature Reviews. Drug Discovery. 11: 937-57. PMID 23197040 DOI: 10.1038/Nrd3871 |
0.357 |
|
| 2012 |
Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3. Plos One. 7: e33175. PMID 22479367 DOI: 10.1371/Journal.Pone.0033175 |
0.44 |
|
| 2012 |
Budas G, Costa HM, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D. Identification of εPKC targets during cardiac ischemic injury. Circulation Journal : Official Journal of the Japanese Circulation Society. 76: 1476-85. PMID 22453000 DOI: 10.1253/Circj.Cj-11-1360 |
0.435 |
|
| 2012 |
Ferreira JC, Mochly-Rosen D, Boutjdir M. Regulation of cardiac excitability by protein kinase C isozymes. Frontiers in Bioscience (Scholar Edition). 4: 532-46. PMID 22202075 DOI: 10.2741/283 |
0.406 |
|
| 2012 |
Ferreira JC, Mochly-Rosen D. Nitroglycerin use in myocardial infarction patients. Circulation Journal : Official Journal of the Japanese Circulation Society. 76: 15-21. PMID 22040938 DOI: 10.1253/Circj.Cj-11-1133 |
0.341 |
|
| 2012 |
Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase Cε is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes Oncogene. 31: 2593-2600. PMID 21996750 DOI: 10.1038/Onc.2011.428 |
0.31 |
|
| 2011 |
Sun L, Ferreira JC, Mochly-Rosen D. ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Science Translational Medicine. 3: 107ra111. PMID 22049071 DOI: 10.1126/Scitranslmed.3002067 |
0.388 |
|
| 2011 |
Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy. Journal of Molecular and Cellular Cardiology. 51: 980-7. PMID 21920368 DOI: 10.1016/J.Yjmcc.2011.08.025 |
0.363 |
|
| 2011 |
Mochly-Rosen D, Grimes KV. Myocardial salvage in acute myocardial infarction--challenges in clinical translation. Journal of Molecular and Cellular Cardiology. 51: 451-3. PMID 21851825 DOI: 10.1016/J.Yjmcc.2011.08.002 |
0.34 |
|
| 2011 |
Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D. β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways. Journal of Molecular and Cellular Cardiology. 51: 781-9. PMID 21756913 DOI: 10.1016/J.Yjmcc.2011.06.019 |
0.308 |
|
| 2011 |
Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W. Therapeutic potential for protein kinase C inhibitor in vascular restenosis. Journal of Cardiovascular Pharmacology and Therapeutics. 16: 160-7. PMID 21183728 DOI: 10.1177/1074248410382106 |
0.361 |
|
| 2011 |
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo. Molecular Biology of the Cell. 22: 256-65. PMID 21119009 DOI: 10.1091/Mbc.E10-06-0551 |
0.493 |
|
| 2011 |
Ferreira JC, Brum PC, Mochly-Rosen D. βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. Journal of Molecular and Cellular Cardiology. 51: 479-84. PMID 21035454 DOI: 10.1016/J.Yjmcc.2010.10.020 |
0.393 |
|
| 2011 |
Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D. PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses. Journal of Cellular and Molecular Medicine. 15: 1769-77. PMID 20874717 DOI: 10.1111/J.1582-4934.2010.01174.X |
0.417 |
|
| 2010 |
Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D. Regulation of mitochondrial processes: a target for heart failure. Drug Discovery Today. Disease Mechanisms. 7: e95-e102. PMID 21278905 DOI: 10.1016/J.Ddmec.2010.07.002 |
0.468 |
|
| 2010 |
Qvit N, Mochly-Rosen D. Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discovery Today. Disease Mechanisms. 7: e87-e93. PMID 21151743 DOI: 10.1016/J.Ddmec.2010.07.001 |
0.391 |
|
| 2010 |
Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting. Circulation. 122: S170-8. PMID 20837910 DOI: 10.1055/S-0030-1268922 |
0.359 |
|
| 2010 |
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells. Circulation. 122: 771-81. PMID 20697027 DOI: 10.1161/Circulationaha.110.952481 |
0.333 |
|
| 2010 |
Chen CH, Sun L, Mochly-Rosen D. Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovascular Research. 88: 51-7. PMID 20558439 DOI: 10.1093/Cvr/Cvq192 |
0.336 |
|
| 2010 |
Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D. Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. Cardiovascular Research. 88: 83-92. PMID 20558438 DOI: 10.1093/Cvr/Cvq154 |
0.421 |
|
| 2010 |
Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice. Journal of Molecular and Cellular Cardiology. 48: 757-64. PMID 19913552 DOI: 10.1016/J.Yjmcc.2009.10.030 |
0.402 |
|
| 2010 |
Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M. deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification. Journal of Molecular and Cellular Cardiology. 48: 746-56. PMID 19913548 DOI: 10.1016/J.Yjmcc.2009.11.002 |
0.377 |
|
| 2010 |
Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion. Cardiovascular Research. 85: 385-94. PMID 19820255 DOI: 10.1093/Cvr/Cvp334 |
0.443 |
|
| 2010 |
Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-rosen D. Mitochondrial import of PKCε is mediated by HSP90: A role in cardioprotection from ischaemia and reperfusion injury Continuing Education in Anaesthesia, Critical Care and Pain. 88: 83-92. |
0.307 |
|
| 2009 |
Budas GR, Disatnik MH, Mochly-Rosen D. Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? Trends in Cardiovascular Medicine. 19: 158-64. PMID 20005475 DOI: 10.1016/J.Tcm.2009.09.003 |
0.462 |
|
| 2009 |
Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. Protein kinase C in heart failure: a therapeutic target? Cardiovascular Research. 82: 229-39. PMID 19168855 DOI: 10.1093/Cvr/Cvp001 |
0.42 |
|
| 2009 |
Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK. Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats. Brain Research. 1251: 256-61. PMID 19063870 DOI: 10.1016/J.Brainres.2008.11.051 |
0.376 |
|
| 2009 |
Churchill EN, Qvit N, Mochly-Rosen D. Rationally designed peptide regulators of protein kinase C. Trends in Endocrinology and Metabolism: Tem. 20: 25-33. PMID 19056296 DOI: 10.1016/J.Tem.2008.10.002 |
0.425 |
|
| 2009 |
Churchill EN, Disatnik MH, Mochly-Rosen D. Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. Journal of Molecular and Cellular Cardiology. 46: 278-84. PMID 18983847 DOI: 10.1016/J.Yjmcc.2008.09.713 |
0.397 |
|
| 2009 |
Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model. International Journal of Cardiology. 133: 256-9. PMID 18242734 DOI: 10.1016/J.Ijcard.2007.11.021 |
0.348 |
|
| 2009 |
Schrepfer S, Deuse T, Reichenspurner H, Robbins R, Mochly-Rosen D. Identifying PKC epsilon as a target molecule to control intimal hyperplasia Transplantationsmedizin: Organ Der Deutschen Transplantationsgesellschaft. 21: 43-44. DOI: 10.1055/S-0029-1246862 |
0.322 |
|
| 2008 |
Palaniyandi SS, Inagaki K, Mochly-Rosen D. Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure. Journal of Molecular and Cellular Cardiology. 45: 779-86. PMID 18804478 DOI: 10.1016/J.Yjmcc.2008.08.009 |
0.383 |
|
| 2008 |
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science (New York, N.Y.). 321: 1493-5. PMID 18787169 DOI: 10.1126/Science.1158554 |
0.396 |
|
| 2008 |
Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D. epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury. Neuroscience Letters. 441: 120-4. PMID 18586397 DOI: 10.1016/J.Neulet.2008.05.080 |
0.598 |
|
| 2008 |
Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats. American Journal of Physiology. Heart and Circulatory Physiology. 295: H220-6. PMID 18487446 DOI: 10.1152/Ajpheart.00289.2008 |
0.317 |
|
| 2008 |
Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D. Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure. Hypertension. 51: 1565-9. PMID 18413490 DOI: 10.1161/Hypertensionaha.107.109637 |
0.371 |
|
| 2008 |
Qi X, Mochly-Rosen D. The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. Journal of Cell Science. 121: 804-13. PMID 18285444 DOI: 10.1242/Jcs.024653 |
0.474 |
|
| 2008 |
Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 117: 886-96. PMID 18250271 DOI: 10.1161/Circulationaha.107.759167 |
0.343 |
|
| 2008 |
Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I. Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways. Molecular Pharmacology. 73: 1105-12. PMID 18202306 DOI: 10.1124/Mol.107.042580 |
0.383 |
|
| 2008 |
Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. The Journal of Clinical Investigation. 118: 173-82. PMID 18097471 DOI: 10.1172/Jci32636 |
0.435 |
|
| 2008 |
Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D. PKC isozymes in chronic cardiac disease: possible therapeutic targets? Annual Review of Pharmacology and Toxicology. 48: 569-99. PMID 17919087 DOI: 10.1146/Annurev.Pharmtox.48.121806.154902 |
0.395 |
|
| 2008 |
Sun L, Mochly-Rosen D. Protein Kinase Cε Regulates Histone Deacetylase 6 in Cardiac Fibrosis Journal of Cardiac Failure. 14: S78. DOI: 10.1016/J.Cardfail.2008.06.434 |
0.358 |
|
| 2008 |
Palaniyandi SS, Inagaki K, Mochly-Rosen D. Inhibition of Epsilon Protein Kinase C Attenuates Cardiac Mast Cell Degranulation and Remodeling in Hypertension Induced Heart Failure Journal of Cardiac Failure. 14: S78. DOI: 10.1016/J.Cardfail.2008.06.432 |
0.417 |
|
| 2007 |
Budas GR, Mochly-Rosen D. Mitochondrial protein kinase Cε (PKCε): Emerging role in cardiac protection from ischaemic damage Biochemical Society Transactions. 35: 1052-1054. PMID 17956277 DOI: 10.1042/Bst0351052 |
0.407 |
|
| 2007 |
Churchill EN, Mochly-Rosen D. The roles of PKCδ and ε isoenzymes in the regulation of myocardial ischaemia/reperfusion injury Biochemical Society Transactions. 35: 1040-1042. PMID 17956273 DOI: 10.1042/Bst0351040 |
0.44 |
|
| 2007 |
Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: A personal account and progress report on transferring academic discoveries to the clinic Biochemical Society Transactions. 35: 1021-1026. PMID 17956268 DOI: 10.1042/Bst0351021 |
0.405 |
|
| 2007 |
Qi X, Vallentin A, Churchill E, Mochly-Rosen D. deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. Journal of Molecular and Cellular Cardiology. 43: 420-8. PMID 17825316 DOI: 10.1016/J.Yjmcc.2007.07.061 |
0.488 |
|
| 2007 |
Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. Journal of Molecular and Cellular Cardiology. 43: 517-22. PMID 17655859 DOI: 10.1016/J.Yjmcc.2007.06.003 |
0.337 |
|
| 2007 |
Battaini F, Mochly-Rosen D. Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacological Research. 55: 461-6. PMID 17582783 DOI: 10.1016/J.Phrs.2007.05.005 |
0.398 |
|
| 2007 |
Kheifets V, Mochly-Rosen D. Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacological Research. 55: 467-76. PMID 17580120 DOI: 10.1016/J.Phrs.2007.04.014 |
0.795 |
|
| 2007 |
Budas GR, Churchill EN, Mochly-Rosen D. Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury. Pharmacological Research. 55: 523-36. PMID 17576073 DOI: 10.1016/J.Phrs.2007.04.005 |
0.399 |
|
| 2007 |
Bright R, Steinberg GK, Mochly-Rosen D. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Research. 1144: 146-55. PMID 17350602 DOI: 10.1016/J.Brainres.2007.01.113 |
0.58 |
|
| 2007 |
Siwko S, Mochly-Rosen D. Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. The International Journal of Biochemistry & Cell Biology. 39: 978-87. PMID 17337233 DOI: 10.1016/J.Biocel.2007.01.018 |
0.693 |
|
| 2007 |
Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D. Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide. Journal of Molecular and Cellular Cardiology. 42: 835-41. PMID 17337000 DOI: 10.1016/J.Yjmcc.2007.01.007 |
0.601 |
|
| 2007 |
Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK. Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1463-75. PMID 17293847 DOI: 10.1038/Sj.Jcbfm.9600450 |
0.396 |
|
| 2007 |
Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovascular Research. 73: 699-709. PMID 17234167 DOI: 10.1016/J.Cardiores.2006.12.011 |
0.358 |
|
| 2007 |
Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. The Journal of Biological Chemistry. 282: 4113-23. PMID 17142835 DOI: 10.1074/Jbc.M608521200 |
0.42 |
|
| 2007 |
Vallentin A, Mochly-Rosen D. RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. The Journal of Biological Chemistry. 282: 1650-7. PMID 17121852 DOI: 10.1074/Jbc.M601710200 |
0.426 |
|
| 2007 |
Mamidipudi V, Miller LD, Mochly-Rosen D, Cartwright CA. Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells. Biochemical and Biophysical Research Communications. 352: 423-30. PMID 17118337 DOI: 10.1016/J.Bbrc.2006.11.034 |
0.397 |
|
| 2006 |
Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. The Journal of Biological Chemistry. 281: 23218-26. PMID 16785226 DOI: 10.1074/Jbc.M602075200 |
0.804 |
|
| 2006 |
Inagaki K, Churchill E, Mochly-Rosen D. Epsilon protein kinase C as a potential therapeutic target for the ischemic heart. Cardiovascular Research. 70: 222-30. PMID 16635641 DOI: 10.1016/J.Cardiores.2006.02.015 |
0.418 |
|
| 2006 |
Inagaki K, Mochly-Rosen D. DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia. Journal of Molecular and Cellular Cardiology. 39: 203-11. PMID 15990110 DOI: 10.1016/J.Yjmcc.2005.05.014 |
0.35 |
|
| 2006 |
Churchill EN, Bright R, Bright C, Leong K, Szweda L, Mochly-Rosen D. A75. Nanoparticles: Novel cardioprotective devices that utilize a preconditioning-like mechanism Journal of Molecular and Cellular Cardiology. 40: 868-869. DOI: 10.1016/J.Yjmcc.2006.03.298 |
0.486 |
|
| 2006 |
Minhas PS, Liu L, Moon PK, Mhatre SD, Wang Q, Coronado M, Contrepois K, Joshi AU, Dove CG, Kvalheim G, Midttun O, Majeti R, Bernstein D, Mochly-Rosen D, Snyder M, et al. O4-02-05: DE NOVO NAD+ SYNTHESIS RESCUES NEUROINFLAMMATION AND ALZHEIMER'S DISEASE PHENOTYPES: MODULATING IMMUNE CELL RESPONSES AND MITOCHONDRIAL BIOENERGETICS Alzheimer's & Dementia. 14: P1403-P1404. DOI: 10.1016/J.Jalz.2018.06.2919 |
0.47 |
|
| 2005 |
Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke; a Journal of Cerebral Circulation. 36: 2781-90. PMID 16254221 DOI: 10.1161/01.Str.0000189996.71237.F7 |
0.605 |
|
| 2005 |
Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S. RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death. Alcoholism, Clinical and Experimental Research. 29: 1749-52. PMID 16205376 DOI: 10.1097/01.Alc.0000179318.48376.Cd |
0.317 |
|
| 2005 |
Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI. Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circulation Research. 97: 78-85. PMID 15961716 DOI: 10.1161/01.Res.0000173896.32522.6E |
0.818 |
|
| 2005 |
Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG. PKC-{epsilon}-dependent survival signals in diabetic hearts. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1343-50. PMID 15894568 DOI: 10.1152/Ajpheart.01200.2004 |
0.8 |
|
| 2005 |
Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC. Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators. The Journal of Thoracic and Cardiovascular Surgery. 129: 1160-7. PMID 15867794 DOI: 10.1016/J.Jtcvs.2004.09.015 |
0.397 |
|
| 2005 |
Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA. Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 730-41. PMID 15716854 DOI: 10.1038/Sj.Jcbfm.9600071 |
0.423 |
|
| 2005 |
Inagaki K, Begley R, Ikeno F, Mochly-Rosen D. Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. Circulation. 111: 44-50. PMID 15611364 DOI: 10.1161/01.Cir.0000151614.22282.F1 |
0.81 |
|
| 2005 |
Bright R, Inagaki K, Yenari MA, Steinberg GK, Mochly-Rosen D. Delivery of a deltaPKC inhibitor peptide improves stroke survival in a rat model of hypertension, and increases cerebral blood flow following transient focal ischemia in normotensive rats Journal of Cerebral Blood Flow & Metabolism. 25: S184-S184. DOI: 10.1038/Sj.Jcbfm.9591524.0184 |
0.541 |
|
| 2004 |
Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC. Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. Circulation. 110: II194-9. PMID 15364862 DOI: 10.1161/01.Cir.0000138389.22905.62 |
0.383 |
|
| 2004 |
Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D. Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. The Journal of Biological Chemistry. 279: 47985-91. PMID 15339931 DOI: 10.1074/Jbc.M405071200 |
0.814 |
|
| 2004 |
Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D. Protein kinase C delta mediates cerebral reperfusion injury in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6880-8. PMID 15295022 DOI: 10.1523/Jneurosci.4474-03.2004 |
0.633 |
|
| 2004 |
Sweitzer SM, Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ. Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. Pain. 110: 281-9. PMID 15275778 DOI: 10.1016/J.Pain.2004.04.004 |
0.319 |
|
| 2004 |
Miller LD, Lee KC, Mochly-Rosen D, Cartwright CA. RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling. Oncogene. 23: 5682-6. PMID 15184885 DOI: 10.1038/Sj.Onc.1207735 |
0.397 |
|
| 2004 |
Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA. Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 24: 636-45. PMID 15181371 DOI: 10.1097/01.Wcb.0000121235.42748.Bf |
0.413 |
|
| 2004 |
Wang J, Bright R, Mochly-Rosen D, Giffard RG. Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology. 47: 136-45. PMID 15165841 DOI: 10.1016/J.Neuropharm.2004.03.009 |
0.591 |
|
| 2004 |
Begley R, Liron T, Baryza J, Mochly-Rosen D. Biodistribution of intracellularly acting peptides conjugated reversibly to Tat. Biochemical and Biophysical Research Communications. 318: 949-54. PMID 15147964 DOI: 10.1016/J.Bbrc.2004.04.121 |
0.771 |
|
| 2004 |
Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ. Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats. The Journal of Pharmacology and Experimental Therapeutics. 309: 616-25. PMID 14762097 DOI: 10.1124/Jpet.103.060350 |
0.311 |
|
| 2004 |
Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D. State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation. The Journal of Biological Chemistry. 279: 17617-24. PMID 14761958 DOI: 10.1074/Jbc.M400962200 |
0.33 |
|
| 2004 |
Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D. A critical intramolecular interaction for protein kinase Cepsilon translocation. The Journal of Biological Chemistry. 279: 15831-40. PMID 14739299 DOI: 10.1074/Jbc.M310696200 |
0.774 |
|
| 2004 |
Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO. Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. The Journal of Biological Chemistry. 279: 3596-604. PMID 14600145 DOI: 10.1074/Jbc.M311459200 |
0.457 |
|
| 2004 |
Braun MU, Mochly-Rosen D. Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors. Journal of Molecular and Cellular Cardiology. 35: 895-903. PMID 12878476 DOI: 10.1016/S0022-2828(03)00142-1 |
0.386 |
|
| 2004 |
Inagaki K, Mochly-Rosen D. 1136-81 Epsilon protein kinase C (PKC) activation by delta PKC in ethanol-induced cardiac protection from ischemia Journal of the American College of Cardiology. 43: A294. DOI: 10.1016/S0735-1097(04)91244-2 |
0.419 |
|
| 2004 |
Tanaka M, Terry RD, Mokhtari G, Hoyt E, Koyanagi T, Inagaki K, Kofidis T, Mochly-Rosen D, Robbins RC. 1051-131 Combined treatment with epsilon protein kinase C activator and delta protein kinase C inhibitor ameliorates ischemia reperfusion injury with prolonged ischemia in rat cardiac allografts Journal of the American College of Cardiology. 43: A176. DOI: 10.1016/S0735-1097(04)90747-4 |
0.436 |
|
| 2004 |
Tanaka M, Terry R, Koyanagi T, Inagaki K, Kofidis T, Mochly-Rosen D, Robbins R. Combined treatment with epsilon protein kinase C activator and delta protein kinase C inhibitor ameliorates ischemia reperfusion injury and graft coronary artery disease in murine cardiac allografts The Journal of Heart and Lung Transplantation. 23: S126. DOI: 10.1016/J.Healun.2003.11.249 |
0.406 |
|
| 2003 |
Murriel CL, Mochly-Rosen D. Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Archives of Biochemistry and Biophysics. 420: 246-54. PMID 14654063 DOI: 10.1016/J.Abb.2003.08.038 |
0.795 |
|
| 2003 |
Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation. 108: 2304-7. PMID 14597593 DOI: 10.1161/01.Cir.0000101682.24138.36 |
0.641 |
|
| 2003 |
Koponen S, Kurkinen K, Akerman KE, Mochly-Rosen D, Chan PH, Koistinaho J. Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta. Journal of Neurochemistry. 86: 442-50. PMID 12871585 DOI: 10.1046/J.1471-4159.2003.01846.X |
0.334 |
|
| 2003 |
Inagaki K, Hahn HS, Dorn GW, Mochly-Rosen D. Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator. Circulation. 108: 869-75. PMID 12860903 DOI: 10.1161/01.Cir.0000081943.93653.73 |
0.466 |
|
| 2003 |
Schechtman D, Murriel C, Bright R, Mochly-Rosen D. Overlay method for detecting protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 233: 351-7. PMID 12840521 DOI: 10.1385/1-59259-397-6:351 |
0.761 |
|
| 2003 |
Xiao GQ, Mochly-Rosen D, Boutjdir M. PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current. Biochemical and Biophysical Research Communications. 306: 1019-25. PMID 12821145 DOI: 10.1016/S0006-291X(03)01095-7 |
0.355 |
|
| 2003 |
Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y. Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. Journal of Molecular and Cellular Cardiology. 34: 1377-85. PMID 12392998 DOI: 10.1006/Jmcc.2002.2089 |
0.373 |
|
| 2003 |
Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA. εPKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice The Journal of Neuroscience. 23: 384-391. DOI: 10.1523/Jneurosci.23-02-00384.2003 |
0.317 |
|
| 2003 |
Murriel CL, Inagaki K, Chen L, Mochly-rosen D. δPKC inhibition during ishchemia and reperfusion: targeting BAD and the cell death machinery Journal of Cardiac Failure. 9: S66. DOI: 10.1016/S1071-9164(03)00551-7 |
0.799 |
|
| 2003 |
Begley RR, Inagaki K, Powers J, Ikeno F, Bernstein D, Mochly-Rosen D. Postnatal cardiac hypertrophy is modulated by εPKC activity Journal of Cardiac Failure. 9: S70. DOI: 10.1016/S1071-9164(03)00193-3 |
0.776 |
|
| 2003 |
Vallentin A, Peleg H, Mochly-Rosen D. RBCK1, a protein kinase C βI binding partner and its splice variant RBCK2: potential role in cardiac hypertrophy? Journal of Cardiac Failure. 9: S70. DOI: 10.1016/S1071-9164(03)00191-X |
0.419 |
|
| 2002 |
Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1970-7. PMID 12003800 DOI: 10.1152/Ajpheart.01029.2001 |
0.397 |
|
| 2002 |
Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI. Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-ε and -δ Molecular Biology of the Cell. 13: 1381-1389. PMID 11950946 DOI: 10.1091/Mbc.01-07-0323 |
0.313 |
|
| 2002 |
Dorn GW, Mochly-Rosen D. Intracellular transport mechanisms of signal transducers. Annual Review of Physiology. 64: 407-29. PMID 11826274 DOI: 10.1146/Annurev.Physiol.64.081501.155903 |
0.406 |
|
| 2002 |
Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D. Molecular dynamics characterization of the C2 domain of protein kinase Cbeta. The Journal of Biological Chemistry. 277: 12988-97. PMID 11782454 DOI: 10.1074/Jbc.M106875200 |
0.761 |
|
| 2002 |
Schechtman D, Mochly-Rosen D. Isozyme-specific inhibitors and activators of protein kinase C. Methods in Enzymology. 345: 470-89. PMID 11665630 DOI: 10.1016/S0076-6879(02)45039-2 |
0.391 |
|
| 2002 |
Lee F, Inagaki K, Chen L, Bailey L, Ikeno F, Lyons J, Bouley D, Yock P, Carter A, Yeung A, Mochly-Rosen D. A novel inhibitor of _protein kinase-C as a therapeutic for ischemic reperfusion injury in acute coronary syndromes Journal of the American College of Cardiology. 39: 445. DOI: 10.1016/S0735-1097(02)81998-2 |
0.603 |
|
| 2002 |
Zhou H, Karliner JS, Zhu P, Mochly-Rosen D, Messing RO, Gray MO. Cardioprotection caused by ischemic preconditioning or by an alpha 1-adrenergic receptor agonist is blocked in hearts from epsilon protein kinase C knockout mice Journal of the American College of Cardiology. 39: 299. DOI: 10.1016/S0735-1097(02)81343-2 |
0.366 |
|
| 2002 |
Bright R, Dembner JM, Yenari MA, Steinberg GK, Mochly-Rosen D. 23 Delta PKC in cerebral ischemic and reperfusion injury in vivo Journal of Molecular and Cellular Cardiology. 34: A38. DOI: 10.1016/S0022-2828(02)90207-5 |
0.547 |
|
| 2002 |
Chen L, Ingaki K, Ikeno F, Lee F, Yock P, Mochly-Rosen D. 22 A role for delta PKC in cardiac reperfusion injury in vivo Journal of Molecular and Cellular Cardiology. 34: A38. DOI: 10.1016/S0022-2828(02)90206-3 |
0.585 |
|
| 2002 |
Inagaki K, Mochly-Rosen D. 21 Enhanced protection of the ischemic heart by combined treatment with δPKC inhibitor and εPKC activator Journal of Molecular and Cellular Cardiology. 34: A38. DOI: 10.1016/S0022-2828(02)90205-1 |
0.367 |
|
| 2002 |
Oldenburg O, Mochly-Rosen D, Cohen MV, Downey JM. 05 Acetylcholine-induced production of reactive oxygen species in A7r5 cells is dependent on protein kinase C Journal of Molecular and Cellular Cardiology. 34: A30. DOI: 10.1016/S0022-2828(02)90176-8 |
0.341 |
|
| 2001 |
Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D. Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chemistry & Biology. 8: 1123-9. PMID 11755391 DOI: 10.1016/S1074-5521(01)00076-X |
0.67 |
|
| 2001 |
Schechtman D, Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene. 20: 6339-47. PMID 11607837 DOI: 10.1038/Sj.Onc.1204778 |
0.408 |
|
| 2001 |
Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW, Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and εPKC Proceedings of the National Academy of Sciences of the United States of America. 98: 11114-11119. PMID 11553773 DOI: 10.1073/Pnas.191369098 |
0.662 |
|
| 2001 |
Mackay K, Mochly-Rosen D. Localization, anchoring, and functions of protein kinase C isozymes in the heart. Journal of Molecular and Cellular Cardiology. 33: 1301-1307. PMID 11437536 DOI: 10.1006/Jmcc.2001.1400 |
0.437 |
|
| 2001 |
Stebbins EG, Mochly-Rosen D. Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. The Journal of Biological Chemistry. 276: 29644-50. PMID 11387319 DOI: 10.1074/Jbc.M101044200 |
0.809 |
|
| 2001 |
Mochly-Rosen D, Fagin JA, Knauf JA, Nikiforov Y, Liron T, Schechtman D. Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis. Advances in Enzyme Regulation. 41: 87-97. PMID 11384739 DOI: 10.1016/S0065-2571(00)00008-X |
0.309 |
|
| 2001 |
Mackay K, Mochly-Rosen D. Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C. Cardiovascular Research. 50: 65-74. PMID 11282079 DOI: 10.1016/S0008-6363(00)00322-9 |
0.421 |
|
| 2001 |
Chen C, Mochly-Rosen D. Opposing effects of delta and xi PKC in ethanol-induced cardioprotection. Journal of Molecular and Cellular Cardiology. 33: 581-5. PMID 11181025 DOI: 10.1006/Jmcc.2000.1330 |
0.358 |
|
| 2000 |
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616 DOI: 10.1152/Ajplung.2000.279.3.L429 |
0.414 |
|
| 2000 |
Mackay K, Mochly-Rosen D. Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia. Journal of Molecular and Cellular Cardiology. 32: 1585-8. PMID 10900183 DOI: 10.1006/Jmcc.2000.1194 |
0.382 |
|
| 2000 |
Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation. Circulation Research. 86: 1173-9. PMID 10850970 DOI: 10.1161/01.Res.86.11.1173 |
0.455 |
|
| 2000 |
Mochly-Rosen D, Kauvar LM. Pharmacological regulation of network kinetics by protein kinase C localization. Seminars in Immunology. 12: 55-61. PMID 10723798 DOI: 10.1006/Smim.2000.0207 |
0.394 |
|
| 2000 |
Aley KO, Messing RO, Mochly-Rosen D, Levine JD. Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C The Journal of Neuroscience. 20: 4680-4685. DOI: 10.1523/Jneurosci.20-12-04680.2000 |
0.334 |
|
| 1999 |
Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proceedings of the National Academy of Sciences of the United States of America. 96: 12798-803. PMID 10536002 DOI: 10.1073/Pnas.96.22.12798 |
0.477 |
|
| 1999 |
Chen CH, Gray MO, Mochly-Rosen D. Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 96: 12784-9. PMID 10536000 DOI: 10.1073/Pnas.96.22.12784 |
0.348 |
|
| 1999 |
Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D. RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry. 38: 13787-94. PMID 10529223 DOI: 10.1021/Bi991055K |
0.326 |
|
| 1999 |
Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes Journal of Molecular and Cellular Cardiology. 31: 1937-1948. PMID 10525430 DOI: 10.1006/Jmcc.1999.1026 |
0.417 |
|
| 1999 |
Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA. Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. The Journal of Biological Chemistry. 274: 23414-25. PMID 10438519 DOI: 10.1074/Jbc.274.33.23414 |
0.342 |
|
| 1999 |
Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D. Characterization of the binding and phosphorylation of cardiac calsequestrin by ε protein kinase C Febs Letters. 454: 240-246. PMID 10431815 DOI: 10.1016/S0014-5793(99)00697-3 |
0.378 |
|
| 1999 |
Csukai M, Mochly-Rosen D. Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation. Pharmacological Research. 39: 253-9. PMID 10208754 DOI: 10.1006/Phrs.1998.0418 |
0.388 |
|
| 1999 |
Mackay K, Mochly-Rosen D. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. The Journal of Biological Chemistry. 274: 6272-9. PMID 10037715 DOI: 10.1074/Jbc.274.10.6272 |
0.434 |
|
| 1998 |
Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. The Journal of Biological Chemistry. 273: 30306-15. PMID 9804792 DOI: 10.1074/Jbc.273.46.30306 |
0.41 |
|
| 1998 |
Souroujon MC, Mochly-Rosen D. Peptide modulators of protein-protein interactions in intracellular signaling. Nature Biotechnology. 16: 919-24. PMID 9788346 DOI: 10.1038/Nbt1098-919 |
0.353 |
|
| 1998 |
Mochly-Rosen D, Kauvar LM. Modulating protein kinase C signal transduction. Advances in Pharmacology (San Diego, Calif.). 44: 91-145. PMID 9547885 DOI: 10.1016/S1054-3589(08)60126-X |
0.359 |
|
| 1998 |
Gray MO, Karliner JS, Mochly-Rosen D. A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. The Journal of Biological Chemistry. 272: 30945-51. PMID 9388241 DOI: 10.1074/Jbc.272.49.30945 |
0.457 |
|
| 1998 |
Mochly-Rosen D, Gordon AS. Anchoring proteins for protein kinase C: a means for isozyme selectivity The Faseb Journal. 12: 35-42. DOI: 10.1096/Fasebj.12.1.35 |
0.415 |
|
| 1997 |
Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D. The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. The Journal of Biological Chemistry. 272: 29200-6. PMID 9360998 DOI: 10.1074/Jbc.272.46.29200 |
0.376 |
|
| 1997 |
Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO. An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters. The Journal of Biological Chemistry. 272: 15028-35. PMID 9169479 DOI: 10.1074/Jbc.272.23.15028 |
0.331 |
|
| 1997 |
Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic β-cells Journal of Biological Chemistry. 272: 1417-1420. PMID 8999804 DOI: 10.1074/Jbc.272.3.1417 |
0.346 |
|
| 1997 |
Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D. An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research. Circulation Research. 79: 1086-99. PMID 8943947 DOI: 10.1161/01.Res.79.6.1086 |
0.39 |
|
| 1996 |
Johnson JA, Gray MO, Chen CH, Mochly-Rosen D. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. The Journal of Biological Chemistry. 271: 24962-6. PMID 8798776 DOI: 10.1074/Jbc.271.40.24962 |
0.446 |
|
| 1996 |
Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA. Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells. The Journal of Investigative Dermatology. 107: 248-52. PMID 8757771 DOI: 10.1111/1523-1747.Ep12329733 |
0.36 |
|
| 1996 |
Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P. The HIV nef protein associates with protein kinase C theta. The Journal of Biological Chemistry. 271: 16753-7. PMID 8663223 DOI: 10.1074/Jbc.271.28.16753 |
0.369 |
|
| 1996 |
Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis. The Journal of Cell Biology. 133: 997-1005. PMID 8655590 DOI: 10.1083/Jcb.133.5.997 |
0.317 |
|
| 1995 |
Disatnik MH, Jones SN, Mochly-Rosen D. Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-β1 in cardiac myocytes Journal of Molecular and Cellular Cardiology. 27: 2473-2481. PMID 8596198 DOI: 10.1006/Jmcc.1995.0235 |
0.341 |
|
| 1995 |
Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D. Interaction of protein kinase C with RACKI, a receptor for activated C-kinase: A role in β protein kinase C mediated signal transduction Biochemical Society Transactions. 23: 596-600. PMID 8566424 DOI: 10.1042/Bst0230596 |
0.376 |
|
| 1995 |
Johnson JA, Mochly-Rosen D. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme. Circulation Research. 76: 654-63. PMID 7895339 DOI: 10.1161/01.Res.76.4.654 |
0.357 |
|
| 1995 |
Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science (New York, N.Y.). 268: 247-51. PMID 7716516 DOI: 10.1126/Science.7716516 |
0.4 |
|
| 1995 |
Johnson JA, Adak S, Mochly-Rosen D. Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes. Life Sciences. 57: 1027-38. PMID 7658910 DOI: 10.1016/0024-3205(95)02048-N |
0.39 |
|
| 1995 |
Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor Proceedings of the National Academy of Sciences of the United States of America. 92: 7824-7828. PMID 7644499 DOI: 10.1073/Pnas.92.17.7824 |
0.388 |
|
| 1995 |
Ron D, Luo J, Mochly-Rosen D. C2 region-derived peptides inhibit translocation and function of β protein kinase C in vivo Journal of Biological Chemistry. 270: 24180-24187. PMID 7592622 DOI: 10.1074/Jbc.270.41.24180 |
0.329 |
|
| 1995 |
Ron D, Mochly-Rosen D. An autoregulatory region in protein kinase C: The pseudoanchoring site Proceedings of the National Academy of Sciences of the United States of America. 92: 492-496. DOI: 10.1073/Pnas.92.2.492 |
0.383 |
|
| 1994 |
Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. Cloning of an intracellular receptor for protein kinase C: A homolog of the β subunit of G proteins Proceedings of the National Academy of Sciences of the United States of America. 91: 839-843. PMID 8302854 DOI: 10.1073/Pnas.91.3.839 |
0.407 |
|
| 1994 |
Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Experimental Cell Research. 210: 287-97. PMID 8299726 DOI: 10.1006/Excr.1994.1041 |
0.415 |
|
| 1994 |
Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D. Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 91: 559-563. PMID 8290562 DOI: 10.1073/Pnas.91.2.559 |
0.378 |
|
| 1994 |
Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. The Journal of Cell Biology. 124: 717-27. PMID 8120094 DOI: 10.1083/Jcb.124.5.717 |
0.31 |
|
| 1992 |
Smith BL, Mochly-Rosen D. Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme. Biochemical and Biophysical Research Communications. 188: 1235-1240. PMID 1332715 DOI: 10.1016/0006-291X(92)91363-U |
0.359 |
|
| 1992 |
Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL. p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C. Biochemistry. 31: 8120-4. PMID 1326322 DOI: 10.1021/Bi00150A003 |
0.351 |
|
| 1991 |
Mochly-Rosen D, Khaner H, Lopez J. Identification of intracellular receptor proteins for activated protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 88: 3997-4000. PMID 1850844 DOI: 10.1073/Pnas.88.9.3997 |
0.382 |
|
| 1991 |
Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E. The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae. Proceedings of the Royal Society B: Biological Sciences. 243: 165-171. PMID 1676520 DOI: 10.1098/Rspb.1991.0027 |
0.393 |
|
| 1990 |
Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC. A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regulation. 1: 693-706. PMID 2078573 DOI: 10.1091/Mbc.1.9.693 |
0.392 |
|
| 1987 |
Mochly-Rosen D, Basbaum AI, Koshland DE. Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 84: 4660-4. PMID 3299372 DOI: 10.1073/Pnas.84.13.4660 |
0.324 |
|
| 1987 |
Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD. Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry. 26: 2886-93. PMID 3111527 DOI: 10.1021/Bi00384A033 |
0.319 |
|
| 1986 |
Bollag GE, Roth RA, Beaudoin J, Mochly-Rosen D, Koshland DE. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 5822-4. PMID 3526339 DOI: 10.1073/Pnas.83.16.5822 |
0.38 |
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