Daria Mochly-rosen - Publications

Stanford University, Palo Alto, CA 
chemical and systems biology

195 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hu YF, Wu CH, Lai TC, Chang YC, Hwang MJ, Chang TY, Weng CH, Chang PM, Chen CH, Mochly-Rosen D, Huang CF, Chen SA. ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: a multi-omics analysis. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166088. PMID 33515676 DOI: 10.1016/j.bbadis.2021.166088  0.48
2021 Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, ... ... Mochly-Rosen D, et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. PMID 33473210 DOI: 10.1038/s41586-020-03160-0  0.96
2020 Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D. Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience. PMID 33324000 DOI: 10.1038/s41593-020-00774-5  0.96
2020 Malkovskiy AV, Van Wassenhove LD, Goltsev Y, Osei-Sarfo K, Chen CH, Efron B, Gudas LJ, Mochly-Rosen D, Rajadas J. The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice. Calcified Tissue International. PMID 33068139 DOI: 10.1007/s00223-020-00769-1  0.48
2020 Chen CH, Ferreira JCB, Joshi AU, Stevens MC, Li SJ, Hsu JH, Maclean R, Ferreira ND, Cervantes PR, Martinez DD, Barrientos FL, Quintanares GHR, Mochly-Rosen D. Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity. Ebiomedicine. 55: 102753. PMID 32403082 DOI: 10.1016/J.Ebiom.2020.102753  0.96
2020 Haileselassie B, Joshi AU, Minhas PS, Mukherjee R, Andreasson KI, Mochly-Rosen D. Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy. Journal of Neuroinflammation. 17: 36. PMID 31987040 DOI: 10.1186/S12974-019-1689-8  0.96
2019 Joshi AU, Van Wassenhove LD, Logas KR, Minhas PS, Andreasson KI, Weinberg KI, Chen CH, Mochly-Rosen D. Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology. Acta Neuropathologica Communications. 7: 190. PMID 31829281 DOI: 10.1186/S40478-019-0839-7  0.96
2019 Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, ... ... Mochly-Rosen D, et al. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 140: 1205-1216. PMID 31769940 DOI: 10.1161/Circulationaha.119.040551  0.32
2019 Chen CH, Ferreira JCB, Mochly-Rosen D, Gross ER. Alcohol consumption and vascular disease: other points to consider. Lancet (London, England). 394: 1617-1618. PMID 31690444 DOI: 10.1016/S0140-6736(19)31880-X  0.48
2019 Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D. Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience. 22: 1635-1648. PMID 31551592 DOI: 10.1038/S41593-019-0486-0  0.96
2019 Chen CH, Ferreira JCB, Mochly-Rosen D. ALDH2 and Cardiovascular Disease. Advances in Experimental Medicine and Biology. 1193: 53-67. PMID 31368097 DOI: 10.1007/978-981-13-6260-6_3  0.48
2019 Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D. Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 30981733 DOI: 10.1016/J.Yjmcc.2019.04.006  0.96
2019 Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D. A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nature Communications. 10: 329. PMID 30659190 DOI: 10.1038/S41467-018-08276-6  1
2018 Joshi AU, Ebert AE, Haileselassie B, Mochly-Rosen D. Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease. Journal of Molecular and Cellular Cardiology. 127: 125-133. PMID 30550751 DOI: 10.1016/J.Yjmcc.2018.12.004  0.96
2018 Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, et al. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nature Immunology. PMID 30478397 DOI: 10.1038/S41590-018-0255-3  0.96
2018 Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, et al. ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells. Cell Chemical Biology. PMID 30293938 DOI: 10.1016/J.Chembiol.2018.09.005  0.48
2018 Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nature Communications. 9: 4045. PMID 30279493 DOI: 10.1038/S41467-018-06447-Z  0.48
2018 Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D. Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. Scientific Reports. 8: 14034. PMID 30232469 DOI: 10.1038/S41598-018-32228-1  0.72
2018 Kiyuna LA, Prestes E Albuquerque R, Chen CH, Mochly-Rosen D, Ferreira JCB. Targeting mitochondrial dysfunction and oxidative stress in heart failure: challenges and opportunities. Free Radical Biology & Medicine. PMID 30227272 DOI: 10.1016/J.Freeradbiomed.2018.09.019  0.48
2018 Joshi AU, Mochly-Rosen D. Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases. Pharmacological Research. PMID 30144530 DOI: 10.1016/J.Phrs.2018.08.010  0.96
2018 Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, ... ... Mochly-Rosen D, et al. Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29794221 DOI: 10.1073/Pnas.1802184115  0.48
2018 Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW. MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science (New York, N.Y.). 360: 336-341. PMID 29674596 DOI: 10.1126/Science.Aao1785  0.32
2018 Ueta CB, Campos JC, Albuquerque RPE, Lima VM, Disatnik MH, Sanchez AB, Chen CH, Medeiros MHG, Yang W, Mochly-Rosen D, Ferreira JCB. Cardioprotection induced by a brief exposure to acetaldehyde:role of aldehyde dehydrogenase 2. Cardiovascular Research. PMID 29579152 DOI: 10.1093/Cvr/Cvy070  0.52
2018 Joshi AU, Saw NL, Shamloo M, Mochly-Rosen D. Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease. Oncotarget. 9: 6128-6143. PMID 29464060 DOI: 10.18632/Oncotarget.23640  0.96
2018 Chang PM, Chen CH, Yeh CC, Lu HJ, Liu TT, Chen MH, Liu CY, Wu ATH, Yang MH, Tai SK, Mochly-Rosen D, Huang CF. Transcriptome analysis and prognosis of ALDH isoforms in human cancer. Scientific Reports. 8: 2713. PMID 29426835 DOI: 10.1038/S41598-018-21123-4  0.48
2018 Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D. Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis. Embo Molecular Medicine. PMID 29335339 DOI: 10.15252/Emmm.201708166  0.96
2017 Danielson B, Chen CH, Kaber G, Mochly-Rosen D, Grimes K, Stern R, Bollyky PL. Human Chitotriosidase Does Not Catabolize Hyaluronan. International Journal of Biological Macromolecules. PMID 29247734 DOI: 10.1016/J.Ijbiomac.2017.11.181  0.48
2017 Maity S, Sadlowski CM, George Lin JM, Chen CH, Peng LH, Lee ES, Vegesna GK, Lee C, Kim SH, Mochly-Rosen D, Kumar S, Murthy N. Thiophene bridged aldehydes (TBAs) image ALDH activity in cells via modulation of intramolecular charge transfer. Chemical Science. 8: 7143-7151. PMID 29081945 DOI: 10.1039/C7Sc03017G  0.48
2017 Hung CL, Chang SC, Chang SH, Chi PC, Lai YJ, Wang SW, Wu YJ, Yeh HI, Lin SJ, Chen CH, Mochly-Rosen D, Wang LY. Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Alcohol Consumption are Associated With Asymptomatic Cardiac Remodeling and Subclinical Systolic Dysfunction in Large Community-Dwelling Asians. Alcohol and Alcoholism (Oxford, Oxfordshire). 1-9. PMID 29016726 DOI: 10.1093/Alcalc/Agx049  0.48
2017 Kim J, Shin JH, Chen CH, Cruz L, Farnebo L, Yang J, Borges P, Kang G, Mochly-Rosen D, Sunwoo JB. Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor. Oncotarget. 8: 52345-52356. PMID 28881734 DOI: 10.18632/Oncotarget.17017  0.48
2017 Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. Autophagy. 0. PMID 28598232 DOI: 10.1080/15548627.2017.1325062  0.32
2017 Kim J, Chen CH, Yang J, Mochly-Rosen D. Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment. Journal of Biomedical Science. 24: 33. PMID 28532411 DOI: 10.1186/S12929-017-0338-8  0.48
2017 Kim J, Ho Shin J, Chen CH, Cruz L, Farnebo L, Yang J, Borges P, Kang G, Mochly-Rosen D, Sunwoo JB. Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor. Oncotarget. PMID 28455980 DOI: 10.18632/oncotarget.17017  0.48
2017 Qvit N, Kornfeld OS, Mochly-Rosen D. Corrigendum: Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics. Angewandte Chemie (International Ed. in English). 56: 2236. PMID 28194928 DOI: 10.1002/Anie.201700072  0.6
2017 Nene A, Chen CH, Disatnik MH, Cruz L, Mochly-Rosen D. Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites. Journal of Biomedical Science. 24: 3. PMID 28056995 DOI: 10.1186/S12929-016-0312-X  0.52
2016 Chen CH, Joshi AU, Mochly-Rosen D. The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration. Acta Neurologica Taiwanica. 25: 111-123. PMID 28382610  0.96
2016 Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironomobe N, Motoda C, Oda N, Chayama K, Chen CH, Gross ER, Mochly-Rosen D, et al. Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese. Journal of Biomedical Science. 23: 89. PMID 27927211 DOI: 10.1186/S12929-016-0304-X  0.48
2016 Qvit N, Kornfeld OS, Mochly-Rosen D. Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics. Angewandte Chemie (International Ed. in English). PMID 27860071 DOI: 10.1002/anie.201605429  0.6
2016 Disatnik MH, Joshi AU, Saw NL, Shamloo M, Leavitt BR, Qi X, Mochly-Rosen D. Potential biomarkers to follow the progression and treatment response of Huntington's disease. The Journal of Experimental Medicine. PMID 27821553 DOI: 10.1084/Jem.20160776  1
2016 Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW. Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature. PMID 27775718 DOI: 10.1038/Nature20156  0.6
2016 Van Wassenhove LD, Mochly-Rosen D, Weinberg KI. Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells. Molecular Genetics and Metabolism. 119: 28-36. PMID 27650066 DOI: 10.1016/J.Ymgme.2016.07.004  0.36
2016 Woods C, Shang C, Taghavi F, Downey P, Zalewski A, Rubio G, Liu J, Homburger J, Grunwald Z, Qi W, Bollensdorff C, Thanaporn P, Ali A, Riemer RK, Kohl P, et al. In vivo Post-Cardiac Arrest Myocardial Dysfunction is Supported by CaMKII-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2. Circulation. PMID 27582424 DOI: 10.1161/Circulationaha.116.021618  0.56
2016 Yu YH, Liao PR, Guo CJ, Chen CH, Mochly-Rosen D, Chuang LM. PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation. Plos One. 11: e0161993. PMID 27575855 DOI: 10.1371/Journal.Pone.0161993  0.48
2016 Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X. VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nature Communications. 7: 12646. PMID 27561680 DOI: 10.1038/Ncomms12646  0.56
2016 Qvit N, Disatnik MH, Sho J, Mochly-Rosen D. Selective phosphorylation inhibitor of δPKC-PDK protein-protein inter-actions; application for myocardial injury in vivo. Journal of the American Chemical Society. PMID 27218445 DOI: 10.1021/Jacs.6B02724  0.52
2016 Joshi AU, Kornfeld OS, Mochly-Rosen D. The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained. Cell Calcium. PMID 27212603 DOI: 10.1016/J.Ceca.2016.04.010  1
2016 Qvit N, Joshi AU, Cunningham AD, Ferreira JC, Mochly-Rosen D. GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death. The Journal of Biological Chemistry. PMID 27129213 DOI: 10.1074/Jbc.M115.711630  1
2016 Qvit N, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang LA, Baron LA, Teh-Poot C, Martínez-Vega P, Ramirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, ... ... Mochly-Rosen D, et al. Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors. International Journal For Parasitology. Drugs and Drug Resistance. 6: 74-84. PMID 27054066 DOI: 10.1016/J.Ijpddr.2016.02.003  0.4
2016 Qvit N, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang L, Baron LA, Teh-Poot C, Martínez-Vega P, Ramirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, ... ... Mochly-Rosen D, et al. Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors International Journal For Parasitology: Drugs and Drug Resistance. 6: 74-84. DOI: 10.1016/j.ijpddr.2016.02.003  0.4
2016 Cunningham AD, Hwang S, Mochly-Rosen D. Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus Clinics in Perinatology. DOI: 10.1016/j.clp.2016.01.010  1
2015 Hwang S, Disatnik MH, Mochly-Rosen D. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. Embo Molecular Medicine. 7: 1307-26. PMID 26268247 DOI: 10.15252/Emmm.201505256  1
2015 Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D. Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases. Circulation Research. 116: 1783-99. PMID 25999419 DOI: 10.1161/Circresaha.116.305432  1
2015 Chen CH, Cruz LA, Mochly-Rosen D. Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. Proceedings of the National Academy of Sciences of the United States of America. 112: 3074-9. PMID 25713355 DOI: 10.1073/Pnas.1414657112  1
2015 Disatnik MH, Hwang S, Ferreira JC, Mochly-Rosen D. New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases. Journal of Molecular Medicine (Berlin, Germany). 93: 279-87. PMID 25652199 DOI: 10.1007/S00109-015-1256-4  1
2015 Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. International Journal of Cardiology. 179: 129-38. PMID 25464432 DOI: 10.1016/J.Ijcard.2014.10.140  1
2015 Gross ER, Zambelli VO, Small BA, Ferreira JC, Chen CH, Mochly-Rosen D. A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant. Annual Review of Pharmacology and Toxicology. 55: 107-27. PMID 25292432 DOI: 10.1146/Annurev-Pharmtox-010814-124915  1
2015 Chiu CC, Yeh TH, Lai SC, Wu-Chou YH, Chen CH, Mochly-Rosen D, Huang YC, Chen YJ, Chen CL, Chang YM, Wang HL, Lu CS. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental Neurology. 263: 244-53. PMID 25263579 DOI: 10.1016/J.Expneurol.2014.09.016  1
2014 Qvit N, Mochly-Rosen D. The many hats of protein kinase Cδ: one enzyme with many functions. Biochemical Society Transactions. 42: 1529-33. PMID 25399565 DOI: 10.1042/Bst20140189  1
2014 Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine. 6: 255ra130. PMID 25253673 DOI: 10.1126/Scitranslmed.3009027  1
2014 Zambelli VO, Gross ER, Chen CH, Gutierrez VP, Cury Y, Mochly-Rosen D. Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Science Translational Medicine. 6: 251ra118. PMID 25163478 DOI: 10.1126/Scitranslmed.3009539  1
2014 Mochly-Rosen D, Disatnik MH, Qi X. The challenge in translating basic research discoveries to treatment of Huntington disease. Rare Diseases (Austin, Tex.). 2: e28637. PMID 25054095 DOI: 10.4161/rdis.28637  1
2014 Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC. Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling. Cardiovascular Research. 103: 498-508. PMID 24817685 DOI: 10.1093/Cvr/Cvu125  1
2014 Zambelli VO, Fernandes AC, Gutierrez VP, Ferreira JC, Parada CA, Mochly-Rosen D, Cury Y. Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats. Plos One. 9: e90576. PMID 24594607 DOI: 10.1371/Journal.Pone.0090576  1
2014 Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD. Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. Journal of Medicinal Chemistry. 57: 714-22. PMID 24444054 DOI: 10.1021/Jm401377V  1
2014 Chen CH, Ferreira JC, Gross ER, Mochly-Rosen D. Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. Physiological Reviews. 94: 1-34. PMID 24382882 DOI: 10.1152/Physrev.00017.2013  1
2013 Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X. Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. The Journal of Clinical Investigation. 123: 5371-88. PMID 24231356 DOI: 10.1172/Jci70911  1
2013 Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D. Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. Journal of the American Heart Association. 2: e000461. PMID 24103571 DOI: 10.1161/Jaha.113.000461  1
2013 Gross ER, Hsu AK, Urban TJ, Mochly-Rosen D, Gross GJ. Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C. Basic Research in Cardiology. 108: 381. PMID 23982492 DOI: 10.1007/S00395-013-0381-X  1
2013 Monti M, Donnini S, Morbidelli L, Giachetti A, Mochly-Rosen D, Mignatti P, Ziche M. PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting. Journal of Molecular and Cellular Cardiology. 63: 107-17. PMID 23880610 DOI: 10.1016/J.Yjmcc.2013.07.006  1
2013 Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4455-64. PMID 23812668 DOI: 10.1158/1078-0432.Ccr-13-0127  1
2013 Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury. The Journal of Biological Chemistry. 288: 18947-60. PMID 23653351 DOI: 10.1074/Jbc.M113.466870  1
2013 Mann DL, Mochly-Rosen D. Translational medicine: mitigating risks for investigators. Nature Reviews. Drug Discovery. 12: 327-8. PMID 23629490 DOI: 10.1038/Nrd4005  1
2013 Solito R, Corti F, Chen CH, Mochly-Rosen D, Giachetti A, Ziche M, Donnini S. Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis. Journal of Cell Science. 126: 1952-61. PMID 23447675 DOI: 10.1242/Jcs.117184  1
2013 Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG. Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice. Journal of Neuroscience Research. 91: 799-807. PMID 23426889 DOI: 10.1002/Jnr.23186  1
2013 Qi X, Qvit N, Su YC, Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. Journal of Cell Science. 126: 789-802. PMID 23239023 DOI: 10.1242/Jcs.114439  1
2013 Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D. In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate. Nmr in Biomedicine. 26: 607-12. PMID 23225495 DOI: 10.1002/Nbm.2897  1
2012 Campos JC, Queliconi BB, Dourado PM, Cunha TF, Zambelli VO, Bechara LR, Kowaltowski AJ, Brum PC, Mochly-Rosen D, Ferreira JC. Exercise training restores cardiac protein quality control in heart failure. Plos One. 7: e52764. PMID 23300764 DOI: 10.1371/Journal.Pone.0052764  1
2012 Mochly-Rosen D, Das K, Grimes KV. Protein kinase C, an elusive therapeutic target? Nature Reviews. Drug Discovery. 11: 937-57. PMID 23197040 DOI: 10.1038/Nrd3871  1
2012 Chang YC, Chiu YF, Lee IT, Ho LT, Hung YJ, Hsiung CA, Quertermous T, Donlon T, Lee WJ, Lee PC, Chen CH, Mochly-Rosen D, Chuang LM. Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption. Bmc Cardiovascular Disorders. 12: 58. PMID 22839215 DOI: 10.1186/1471-2261-12-58  1
2012 Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3. Plos One. 7: e33175. PMID 22479367 DOI: 10.1371/Journal.Pone.0033175  1
2012 Budas G, Costa HM, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D. Identification of εPKC targets during cardiac ischemic injury. Circulation Journal : Official Journal of the Japanese Circulation Society. 76: 1476-85. PMID 22453000 DOI: 10.1253/Circj.Cj-11-1360  1
2012 Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D. Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice. Radiation Research. 178: 69-74. PMID 22404739 DOI: 10.1667/Rr2861.1  1
2012 Ferreira JC, Mochly-Rosen D, Boutjdir M. Regulation of cardiac excitability by protein kinase C isozymes. Frontiers in Bioscience (Scholar Edition). 4: 532-46. PMID 22202075 DOI: 10.2741/283  1
2012 Ferreira JC, Mochly-Rosen D. Nitroglycerin use in myocardial infarction patients. Circulation Journal : Official Journal of the Japanese Circulation Society. 76: 15-21. PMID 22040938 DOI: 10.1253/Circj.Cj-11-1133  1
2012 Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase Cε is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes Oncogene. 31: 2593-2600. PMID 21996750 DOI: 10.1038/Onc.2011.428  1
2011 Sun L, Ferreira JC, Mochly-Rosen D. ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Science Translational Medicine. 3: 107ra111. PMID 22049071 DOI: 10.1126/Scitranslmed.3002067  1
2011 Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. The Journal of Biological Chemistry. 286: 43486-94. PMID 22021038 DOI: 10.1074/Jbc.M111.293597  1
2011 Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, et al. A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 7265-72. PMID 21998334 DOI: 10.1158/1078-0432.Ccr-11-0179  1
2011 Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy. Journal of Molecular and Cellular Cardiology. 51: 980-7. PMID 21920368 DOI: 10.1016/J.Yjmcc.2011.08.025  1
2011 Mochly-Rosen D, Grimes KV. Myocardial salvage in acute myocardial infarction--challenges in clinical translation. Journal of Molecular and Cellular Cardiology. 51: 451-3. PMID 21851825 DOI: 10.1016/J.Yjmcc.2011.08.002  1
2011 Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D. β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways. Journal of Molecular and Cellular Cardiology. 51: 781-9. PMID 21756913 DOI: 10.1016/J.Yjmcc.2011.06.019  1
2011 Kim J, Koyanagi T, Mochly-Rosen D. PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells. The Prostate. 71: 946-54. PMID 21541971 DOI: 10.1002/Pros.21310  1
2011 Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W. Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells. Journal of Vascular Surgery. 53: 1044-51. PMID 21277149 DOI: 10.1016/J.Jvs.2010.10.117  1
2011 Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W. Therapeutic potential for protein kinase C inhibitor in vascular restenosis. Journal of Cardiovascular Pharmacology and Therapeutics. 16: 160-7. PMID 21183728 DOI: 10.1177/1074248410382106  1
2011 Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo. Molecular Biology of the Cell. 22: 256-65. PMID 21119009 DOI: 10.1091/Mbc.E10-06-0551  1
2011 Ferreira JC, Brum PC, Mochly-Rosen D. βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. Journal of Molecular and Cellular Cardiology. 51: 479-84. PMID 21035454 DOI: 10.1016/J.Yjmcc.2010.10.020  1
2011 Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D. PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses. Journal of Cellular and Molecular Medicine. 15: 1769-77. PMID 20874717 DOI: 10.1111/J.1582-4934.2010.01174.X  1
2011 Kim J, Thorne SH, Sun L, Huang B, Mochly-Rosen D. Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model. Oncogene. 30: 323-33. PMID 20856202 DOI: 10.1038/Onc.2010.415  1
2010 Mochly-Rosen D, Zakhari S. Focus on: The cardiovascular system: what did we learn from the French (Paradox)? Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 33: 76-86. PMID 23579938  1
2010 Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D. Regulation of mitochondrial processes: a target for heart failure. Drug Discovery Today. Disease Mechanisms. 7: e95-e102. PMID 21278905 DOI: 10.1016/J.Ddmec.2010.07.002  1
2010 Qvit N, Mochly-Rosen D. Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discovery Today. Disease Mechanisms. 7: e87-e93. PMID 21151743 DOI: 10.1016/J.Ddmec.2010.07.001  1
2010 Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting. Circulation. 122: S170-8. PMID 20837910 DOI: 10.1055/S-0030-1268922  1
2010 Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells. Circulation. 122: 771-81. PMID 20697027 DOI: 10.1161/Circulationaha.110.952481  1
2010 Chen CH, Sun L, Mochly-Rosen D. Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovascular Research. 88: 51-7. PMID 20558439 DOI: 10.1093/Cvr/Cvq192  1
2010 Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D. Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. Cardiovascular Research. 88: 83-92. PMID 20558438 DOI: 10.1093/Cvr/Cvq154  1
2010 Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. Non-volume-loaded heart provides a more relevant heterotopic transplantation model. Transplant Immunology. 23: 65-70. PMID 20403439 DOI: 10.1016/J.Trim.2010.04.005  1
2010 Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nature Structural & Molecular Biology. 17: 159-64. PMID 20062057 DOI: 10.1038/Nsmb.1737  1
2010 Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice. Journal of Molecular and Cellular Cardiology. 48: 757-64. PMID 19913552 DOI: 10.1016/J.Yjmcc.2009.10.030  1
2010 Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M. deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification. Journal of Molecular and Cellular Cardiology. 48: 746-56. PMID 19913548 DOI: 10.1016/J.Yjmcc.2009.11.002  1
2010 Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion. Cardiovascular Research. 85: 385-94. PMID 19820255 DOI: 10.1093/Cvr/Cvp334  1
2010 Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-rosen D. Mitochondrial import of PKCε is mediated by HSP90: A role in cardioprotection from ischaemia and reperfusion injury Continuing Education in Anaesthesia, Critical Care and Pain. 88: 83-92.  1
2010 Mochly-Rosen D, Qvit N. Peptide inhibitors of protein-protein interactions: From rational design to the clinic Chimica Oggi. 28: 14-16.  1
2009 Budas GR, Disatnik MH, Mochly-Rosen D. Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? Trends in Cardiovascular Medicine. 19: 158-64. PMID 20005475 DOI: 10.1016/J.Tcm.2009.09.003  1
2009 Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. Protein kinase C in heart failure: a therapeutic target? Cardiovascular Research. 82: 229-39. PMID 19168855 DOI: 10.1093/Cvr/Cvp001  1
2009 Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK. Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats. Brain Research. 1251: 256-61. PMID 19063870 DOI: 10.1016/J.Brainres.2008.11.051  1
2009 Churchill EN, Qvit N, Mochly-Rosen D. Rationally designed peptide regulators of protein kinase C. Trends in Endocrinology and Metabolism: Tem. 20: 25-33. PMID 19056296 DOI: 10.1016/J.Tem.2008.10.002  1
2009 Churchill EN, Disatnik MH, Mochly-Rosen D. Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. Journal of Molecular and Cellular Cardiology. 46: 278-84. PMID 18983847 DOI: 10.1016/J.Yjmcc.2008.09.713  1
2009 Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model. International Journal of Cardiology. 133: 256-9. PMID 18242734 DOI: 10.1016/J.Ijcard.2007.11.021  1
2009 Schrepfer S, Deuse T, Reichenspurner H, Robbins R, Mochly-Rosen D. Identifying PKC epsilon as a target molecule to control intimal hyperplasia Transplantationsmedizin: Organ Der Deutschen Transplantationsgesellschaft. 21: 43-44. DOI: 10.1055/S-0029-1246862  1
2008 Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D. Ethanol for cardiac ischemia: the role of protein kinase c. Therapeutic Advances in Cardiovascular Disease. 2: 469-83. PMID 19124442 DOI: 10.1177/1753944708094735  1
2008 Palaniyandi SS, Inagaki K, Mochly-Rosen D. Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure. Journal of Molecular and Cellular Cardiology. 45: 779-86. PMID 18804478 DOI: 10.1016/J.Yjmcc.2008.08.009  1
2008 Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science (New York, N.Y.). 321: 1493-5. PMID 18787169 DOI: 10.1126/Science.1158554  1
2008 Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D. Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Research. 68: 6831-9. PMID 18701509 DOI: 10.1158/0008-5472.Can-07-6195  1
2008 Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D. epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury. Neuroscience Letters. 441: 120-4. PMID 18586397 DOI: 10.1016/J.Neulet.2008.05.080  1
2008 Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats. American Journal of Physiology. Heart and Circulatory Physiology. 295: H220-6. PMID 18487446 DOI: 10.1152/Ajpheart.00289.2008  1
2008 Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D. Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure. Hypertension. 51: 1565-9. PMID 18413490 DOI: 10.1161/Hypertensionaha.107.109637  1
2008 Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ. Islet Cell Survival During Isolation Improved Through Protein Kinase C Epsilon Activation Transplantation Proceedings. 40: 375-378. PMID 18374073 DOI: 10.1016/j.transproceed.2008.01.014  1
2008 Qi X, Mochly-Rosen D. The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. Journal of Cell Science. 121: 804-13. PMID 18285444 DOI: 10.1242/Jcs.024653  1
2008 Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 117: 886-96. PMID 18250271 DOI: 10.1161/Circulationaha.107.759167  1
2008 Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I. Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways. Molecular Pharmacology. 73: 1105-12. PMID 18202306 DOI: 10.1124/Mol.107.042580  1
2008 Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. The Journal of Clinical Investigation. 118: 173-82. PMID 18097471 DOI: 10.1172/Jci32636  1
2008 Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D. PKC isozymes in chronic cardiac disease: possible therapeutic targets? Annual Review of Pharmacology and Toxicology. 48: 569-99. PMID 17919087 DOI: 10.1146/Annurev.Pharmtox.48.121806.154902  1
2007 Newton AC, Mochly-Rosen D. Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007). Iubmb Life. 59: 741-3. PMID 18085473 DOI: 10.1080/15216540701697438  1
2007 Budas GR, Mochly-Rosen D. Mitochondrial protein kinase Cε (PKCε): Emerging role in cardiac protection from ischaemic damage Biochemical Society Transactions. 35: 1052-1054. PMID 17956277 DOI: 10.1042/Bst0351052  1
2007 Churchill EN, Mochly-Rosen D. The roles of PKCδ and ε isoenzymes in the regulation of myocardial ischaemia/reperfusion injury Biochemical Society Transactions. 35: 1040-1042. PMID 17956273 DOI: 10.1042/Bst0351040  1
2007 Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: A personal account and progress report on transferring academic discoveries to the clinic Biochemical Society Transactions. 35: 1021-1026. PMID 17956268 DOI: 10.1042/Bst0351021  1
2007 Qi X, Vallentin A, Churchill E, Mochly-Rosen D. deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. Journal of Molecular and Cellular Cardiology. 43: 420-8. PMID 17825316 DOI: 10.1016/J.Yjmcc.2007.07.061  1
2007 Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. Journal of Molecular and Cellular Cardiology. 43: 517-22. PMID 17655859 DOI: 10.1016/J.Yjmcc.2007.06.003  1
2007 Battaini F, Mochly-Rosen D. Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacological Research. 55: 461-6. PMID 17582783 DOI: 10.1016/J.Phrs.2007.05.005  1
2007 Kheifets V, Mochly-Rosen D. Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacological Research. 55: 467-76. PMID 17580120 DOI: 10.1016/J.Phrs.2007.04.014  1
2007 Budas GR, Churchill EN, Mochly-Rosen D. Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury. Pharmacological Research. 55: 523-36. PMID 17576073 DOI: 10.1016/J.Phrs.2007.04.005  1
2007 Bright R, Steinberg GK, Mochly-Rosen D. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Research. 1144: 146-55. PMID 17350602 DOI: 10.1016/J.Brainres.2007.01.113  1
2007 Siwko S, Mochly-Rosen D. Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. The International Journal of Biochemistry & Cell Biology. 39: 978-87. PMID 17337233 DOI: 10.1016/J.Biocel.2007.01.018  1
2007 Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D. Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide. Journal of Molecular and Cellular Cardiology. 42: 835-41. PMID 17337000 DOI: 10.1016/J.Yjmcc.2007.01.007  1
2007 Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK. Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1463-75. PMID 17293847 DOI: 10.1038/Sj.Jcbfm.9600450  1
2007 Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovascular Research. 73: 699-709. PMID 17234167 DOI: 10.1016/J.Cardiores.2006.12.011  1
2007 Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. The Journal of Biological Chemistry. 282: 4113-23. PMID 17142835 DOI: 10.1074/Jbc.M608521200  1
2007 Vallentin A, Mochly-Rosen D. RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. The Journal of Biological Chemistry. 282: 1650-7. PMID 17121852 DOI: 10.1074/Jbc.M601710200  1
2007 Mamidipudi V, Miller LD, Mochly-Rosen D, Cartwright CA. Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells. Biochemical and Biophysical Research Communications. 352: 423-30. PMID 17118337 DOI: 10.1016/J.Bbrc.2006.11.034  1
2006 Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D. Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. The Journal of Biological Chemistry. 281: 23218-26. PMID 16785226 DOI: 10.1074/Jbc.M602075200  1
2006 Inagaki K, Churchill E, Mochly-Rosen D. Epsilon protein kinase C as a potential therapeutic target for the ischemic heart. Cardiovascular Research. 70: 222-30. PMID 16635641 DOI: 10.1016/J.Cardiores.2006.02.015  0.4
2005 Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke; a Journal of Cerebral Circulation. 36: 2781-90. PMID 16254221 DOI: 10.1161/01.Str.0000189996.71237.F7  1
2005 Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM. Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes. The Journal of Pain : Official Journal of the American Pain Society. 6: 535-49. PMID 16084468 DOI: 10.1016/J.Jpain.2005.03.005  1
2005 Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI. Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circulation Research. 97: 78-85. PMID 15961716 DOI: 10.1161/01.Res.0000173896.32522.6E  1
2005 Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC. Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators. The Journal of Thoracic and Cardiovascular Surgery. 129: 1160-7. PMID 15867794 DOI: 10.1016/J.Jtcvs.2004.09.015  1
2005 Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA. Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 730-41. PMID 15716854 DOI: 10.1038/Sj.Jcbfm.9600071  1
2005 Li HF, Mochly-Rosen D, Kendig JJ. Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons. British Journal of Pharmacology. 144: 301-7. PMID 15655532 DOI: 10.1038/Sj.Bjp.0706033  1
2005 Inagaki K, Begley R, Ikeno F, Mochly-Rosen D. Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. Circulation. 111: 44-50. PMID 15611364 DOI: 10.1161/01.Cir.0000151614.22282.F1  0.4
2004 Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC. Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. Circulation. 110: II194-9. PMID 15364862 DOI: 10.1161/01.Cir.0000138389.22905.62  1
2004 Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D. Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. The Journal of Biological Chemistry. 279: 47985-91. PMID 15339931 DOI: 10.1074/Jbc.M405071200  1
2004 Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D. Protein kinase C delta mediates cerebral reperfusion injury in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6880-8. PMID 15295022 DOI: 10.1523/Jneurosci.4474-03.2004  1
2004 Sweitzer SM, Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ. Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. Pain. 110: 281-9. PMID 15275778 DOI: 10.1016/J.Pain.2004.04.004  1
2004 Wang J, Bright R, Mochly-Rosen D, Giffard RG. Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology. 47: 136-45. PMID 15165841 DOI: 10.1016/J.Neuropharm.2004.03.009  1
2004 Begley R, Liron T, Baryza J, Mochly-Rosen D. Biodistribution of intracellularly acting peptides conjugated reversibly to Tat. Biochemical and Biophysical Research Communications. 318: 949-54. PMID 15147964 DOI: 10.1016/J.Bbrc.2004.04.121  0.32
2004 Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ. Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats. The Journal of Pharmacology and Experimental Therapeutics. 309: 616-25. PMID 14762097 DOI: 10.1124/Jpet.103.060350  1
2004 Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D. State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation. The Journal of Biological Chemistry. 279: 17617-24. PMID 14761958 DOI: 10.1074/Jbc.M400962200  1
2004 Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D. A critical intramolecular interaction for protein kinase Cepsilon translocation. The Journal of Biological Chemistry. 279: 15831-40. PMID 14739299 DOI: 10.1074/Jbc.M310696200  1
2004 Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO. Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. The Journal of Biological Chemistry. 279: 3596-604. PMID 14600145 DOI: 10.1074/Jbc.M311459200  1
2003 Murriel CL, Mochly-Rosen D. Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Archives of Biochemistry and Biophysics. 420: 246-54. PMID 14654063 DOI: 10.1016/J.Abb.2003.08.038  0.72
2003 Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation. 108: 2304-7. PMID 14597593 DOI: 10.1161/01.Cir.0000101682.24138.36  1
2003 Inagaki K, Hahn HS, Dorn GW, Mochly-Rosen D. Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator. Circulation. 108: 869-75. PMID 12860903 DOI: 10.1161/01.Cir.0000081943.93653.73  0.44
2003 Schechtman D, Murriel C, Bright R, Mochly-Rosen D. Overlay method for detecting protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 233: 351-7. PMID 12840521 DOI: 10.1385/1-59259-397-6:351  1
2002 Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Moehly-Rosen D, Hamm HE. The βγ subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins Journal of Biological Chemistry. 277: 49888-49895. PMID 12359736 DOI: 10.1074/Jbc.M202755200  0.36
2002 Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1970-7. PMID 12003800 DOI: 10.1152/Ajpheart.01029.2001  1
2002 Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA. Isozyme-specific abnormalities of PKC in thyroid cancer: Evidence for post-transcriptional changes in PKC epsilon Journal of Clinical Endocrinology and Metabolism. 87: 2150-2159. PMID 11994357 DOI: 10.1210/Jcem.87.5.8441  1
2002 Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI. Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-ε and -δ Molecular Biology of the Cell. 13: 1381-1389. PMID 11950946 DOI: 10.1091/Mbc.01-07-0323  1
2002 Dorn GW, Mochly-Rosen D. Intracellular transport mechanisms of signal transducers. Annual Review of Physiology. 64: 407-29. PMID 11826274 DOI: 10.1146/Annurev.Physiol.64.081501.155903  0.32
2002 Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D. Molecular dynamics characterization of the C2 domain of protein kinase Cbeta. The Journal of Biological Chemistry. 277: 12988-97. PMID 11782454 DOI: 10.1074/Jbc.M106875200  1
2001 Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW, Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and εPKC Proceedings of the National Academy of Sciences of the United States of America. 98: 11114-11119. PMID 11553773 DOI: 10.1073/Pnas.191369098  1
2001 Stebbins EG, Mochly-Rosen D. Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. The Journal of Biological Chemistry. 276: 29644-50. PMID 11387319 DOI: 10.1074/Jbc.M101044200  1
2000 Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616 DOI: 10.1152/Ajplung.2000.279.3.L429  1
1999 Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes Journal of Molecular and Cellular Cardiology. 31: 1937-1948. PMID 10525430 DOI: 10.1006/Jmcc.1999.1026  1
1999 Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA. Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis. The Journal of Biological Chemistry. 274: 23414-25. PMID 10438519 DOI: 10.1074/Jbc.274.33.23414  1
1998 Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM. Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption. Proceedings of the National Academy of Sciences of the United States of America. 95: 8262-7. PMID 9653175 DOI: 10.1073/pnas.95.14.8262  1
1997 Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic β-cells Journal of Biological Chemistry. 272: 1417-1420. PMID 8999804 DOI: 10.1074/Jbc.272.3.1417  1
1996 Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE. Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis. The Journal of Cell Biology. 133: 997-1005. PMID 8655590 DOI: 10.1083/Jcb.133.5.997  1
1995 Disatnik MH, Jones SN, Mochly-Rosen D. Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-β1 in cardiac myocytes Journal of Molecular and Cellular Cardiology. 27: 2473-2481. PMID 8596198 DOI: 10.1006/Jmcc.1995.0235  1
1995 Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D. Interaction of protein kinase C with RACKI, a receptor for activated C-kinase: A role in β protein kinase C mediated signal transduction Biochemical Society Transactions. 23: 596-600. PMID 8566424 DOI: 10.1042/Bst0230596  1
1995 Johnson JA, Adak S, Mochly-Rosen D. Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes. Life Sciences. 57: 1027-38. PMID 7658910 DOI: 10.1016/0024-3205(95)02048-N  1
1995 Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor Proceedings of the National Academy of Sciences of the United States of America. 92: 7824-7828. PMID 7644499 DOI: 10.1073/Pnas.92.17.7824  1
1994 Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. Cloning of an intracellular receptor for protein kinase C: A homolog of the β subunit of G proteins Proceedings of the National Academy of Sciences of the United States of America. 91: 839-843. PMID 8302854 DOI: 10.1073/Pnas.91.3.839  1
1994 Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE. Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. The Journal of Cell Biology. 124: 717-27. PMID 8120094 DOI: 10.1083/Jcb.124.5.717  1
1988 Mochly-Rosen D, Chang FH, Cheever L, Kim M, Diamond I, Gordon AS. Chronic ethanol causes heterologous desensitization of receptors by reducing alpha s messenger RNA. Nature. 333: 848-50. PMID 2838757 DOI: 10.1038/333848A0  1
1987 Mochly-Rosen D, Basbaum AI, Koshland DE. Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 84: 4660-4. PMID 3299372 DOI: 10.1073/Pnas.84.13.4660  1
1980 Fuchs S, Bartfeld D, Eshhar Z, Feingold C, Mochly-Rosen D, Novick D, Schwartz M, Tarrab-Hazdai R. Immune regulation of experimental myasthenia Journal of Neurology, Neurosurgery and Psychiatry. 43: 634-643. PMID 7400824 DOI: 10.1136/Jnnp.43.7.634  1
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