Hyoung-gon Lee - Publications

Affiliations: 
Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Alzheimer disease

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Patrick S, Corrigan R, Grizzani J, Mey M, Blair J, Pallas M, Camins A, Lee HG, Casadesus G. Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms. Journal of Alzheimer's Disease : Jad. PMID 30958347 DOI: 10.3233/JAD-180421  1
2018 Wang C, Zhao F, Shen K, Wang W, Siedlak SL, Lee HG, Phelix CF, Perry G, Shen L, Tang B, Yan R, Zhu X. The sterol regulatory element-binding protein 2 is likely dysregulated by tau alterations in Alzheimer disease. Brain Pathology (Zurich, Switzerland). PMID 30515907 DOI: 10.1111/bpa.12691  1
2018 Jiang S, Nandy P, Wang W, Ma X, Hsia J, Wang C, Wang Z, Niu M, Siedlak SL, Torres S, Fujioka H, Xu Y, Lee HG, Perry G, Liu J, et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Molecular Neurodegeneration. 13: 5. PMID 29391029 DOI: 10.1186/s13024-018-0238-8  1
2017 Nunomura A, Lee HG, Zhu X, Perry G. Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders. Biochemical Society Transactions. PMID 28778984 DOI: 10.1042/BST20160433  1
2017 Rajasekhar K, Narayanaswamy N, Murugan NA, Viccaro K, Lee HG, Shah K, Govindaraju T. Aβ plaque-selective NIR fluorescence probe to differentiate Alzheimer's disease from tauopathies. Biosensors & Bioelectronics. 98: 54-61. PMID 28649025 DOI: 10.1016/j.bios.2017.06.030  0.4
2017 Kim HJ, Choi HS, Park JH, Kim MJ, Lee HG, Petersen RB, Kim YS, Park JB, Choi EK. Regulation of RhoA activity by the cellular prion protein. Cell Death & Disease. 8: e2668. PMID 28300846 DOI: 10.1038/cddis.2017.37  1
2017 Willis MS, Holley DW, Wang Z, Chen X, Quintana M, Jensen BC, Tannu M, Parker J, Jeyaraj D, Jain MK, Wolfram JA, Lee HG, Bultman SJ. BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility. Journal of Molecular and Cellular Cardiology. PMID 28232072 DOI: 10.1016/j.yjmcc.2017.02.003  0.44
2016 Shi C, Viccaro K, Lee HG, Shah K. Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. Journal of Cell Science. 129: 1815-1830. PMID 28157684 DOI: 10.1242/jcs.185009  0.4
2016 Grizzanti J, Lee HG, Camins A, Pallas M, Casadesus G. The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer disease. Nutrition Research (New York, N.Y.). PMID 27923524 DOI: 10.1016/j.nutres.2016.11.002  1
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Correction: Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0157209. PMID 27258001 DOI: 10.1371/journal.pone.0157209  0.36
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0151615. PMID 26982086 DOI: 10.1371/journal.pone.0151615  1
2016 Shi C, Viccaro K, Lee HG, Shah K. Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. Journal of Cell Science. PMID 26962010 DOI: 10.1242/jcs.185009  0.4
2015 Zhang F, Su B, Wang C, Siedlak SL, Mondragon-Rodriguez S, Lee HG, Wang X, Perry G, Zhu X. Posttranslational modifications of α-tubulin in alzheimer disease. Translational Neurodegeneration. 4: 9. PMID 26029362 DOI: 10.1186/s40035-015-0030-4  1
2015 Gerenu G, Liu K, Chojnacki JE, Saathoff JM, Martínez-Martín P, Perry G, Zhu X, Lee HG, Zhang S. Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model. Acs Chemical Neuroscience. PMID 25893520 DOI: 10.1021/acschemneuro.5b00082  1
2015 Hradek AC, Lee HP, Siedlak SL, Torres SL, Jung W, Han AH, Lee HG. Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients. Journal of Alzheimer's Disease : Jad. 43: 57-65. PMID 25061053 DOI: 10.3233/JAD-141083  0.8
2014 Lim S, Yoo BK, Kim HS, Gilmore HL, Lee Y, Lee HP, Kim SJ, Letterio J, Lee HG. Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer. Bmc Cancer. 14: 928. PMID 25491510 DOI: 10.1186/1471-2407-14-928  0.8
2014 Bonda DJ, Wang X, Lee HG, Smith MA, Perry G, Zhu X. Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass. Neuroscience Bulletin. 30: 243-52. PMID 24733654 DOI: 10.1007/s12264-013-1424-x  1
2014 Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. Journal of Neurochemistry. 130: 115-25. PMID 24601954 DOI: 10.1111/jnc.12706  1
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  1
2014 Adler BL, Yarchoan M, Hwang HM, Louneva N, Blair JA, Palm R, Smith MA, Lee HG, Arnold SE, Casadesus G. Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition. Neurobiology of Aging. 35: 793-801. PMID 24239383 DOI: 10.1016/j.neurobiolaging.2013.10.076  1
2014 Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochimica Et Biophysica Acta. 1842: 1240-7. PMID 24189435 DOI: 10.1016/j.bbadis.2013.10.015  1
2014 Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. Journal of Neurochemistry. 128: 162-72. PMID 23895348 DOI: 10.1111/jnc.12380  1
2013 Hou L, Lee HG, Han F, Tedesco JM, Perry G, Smith MA, Zagorski MG. Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. Journal of Alzheimer's Disease : Jad. 37: 9-18. PMID 23719512 DOI: 10.3233/JAD-122389  1
2013 Kudo W, Petersen RB, Lee HG. Cellular prion protein and Alzheimer disease: link to oligomeric amyloid-β and neuronal cell death. Prion. 7: 114-6. PMID 23154635 DOI: 10.4161/pri.22848  1
2012 Hong Y, Chan CB, Kwon IS, Li X, Song M, Lee HP, Liu X, Sompol P, Jin P, Lee HG, Yu SP, Ye K. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17262-72. PMID 23197718 DOI: 10.1523/JNEUROSCI.3300-12.2012  0.8
2012 Rodrigues R, Smith MA, Wang X, Perry G, Lee HG, Zhu X, Petersen RB. Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress. Future Neurology. 7: 287-305. PMID 23086377 DOI: 10.2217/fnl.12.27  1
2012 Liu K, Guo TL, Chojnacki J, Lee HG, Wang X, Siedlak SL, Rao W, Zhu X, Zhang S. Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease. Acs Chemical Neuroscience. 3: 141-146. PMID 22685625 DOI: 10.1021/cn200122j  1
2012 Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotoxicity Research. 22: 231-48. PMID 22669748 DOI: 10.1007/s12640-012-9331-x  1
2012 Casadesús G, Gutierrez-Cuesta J, Lee HG, Jiménez A, Tajes M, Ortuño-Sahagún D, Camins A, Smith MA, Pallàs M. Neuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8). Journal of Alzheimer's Disease : Jad. 30: 573-83. PMID 22451322 DOI: 10.3233/JAD-2012-120112  1
2012 Palm R, Ayala-Fontanez N, Garcia Y, Lee HG, Smith MA, Casadesus G. Neuroendocrinology-based therapy for Alzheimer's disease. Biofactors (Oxford, England). 38: 123-32. PMID 22438197 DOI: 10.1002/biof.1011  1
2012 Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, et al. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metabolism. 15: 311-23. PMID 22405069 DOI: 10.1016/j.cmet.2012.01.020  1
2012 Reed-Cossairt A, Zhu X, Lee HG, Reed C, Perry G, Petersen RB. Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Current Gerontology and Geriatrics Research. 2012: 929734. PMID 22400025 DOI: 10.1155/2012/929734  1
2012 Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 39: 4. PMID 22384486  1
2012 Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. Journal of Neuropathology and Experimental Neurology. 71: 233-41. PMID 22318126 DOI: 10.1097/NEN.0b013e318248e614  1
2012 Lee HP, Pancholi N, Esposito L, Previll LA, Wang X, Zhu X, Smith MA, Lee HG. Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. Plos One. 7: e28033. PMID 22276093 DOI: 10.1371/journal.pone.0028033  0.8
2012 Santos RX, Correia SC, Zhu X, Lee HG, Petersen RB, Nunomura A, Smith MA, Perry G, Moreira PI. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radical Research. 46: 565-76. PMID 22149654 DOI: 10.3109/10715762.2011.648188  1
2012 Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG. Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human Molecular Genetics. 21: 1138-44. PMID 22100763 DOI: 10.1093/hmg/ddr542  0.68
2012 Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. Journal of Neurochemistry. 120: 419-29. PMID 22077634 DOI: 10.1111/j.1471-4159.2011.07581.x  1
2011 Ziats NP, Petersen RB, Lee HG, Castellani RJ, Perry G, Zhu X. Mark A. Smith, 1965-2010: consummate student of pathogenesis. International Journal of Clinical and Experimental Pathology. 4: 731-2. PMID 22076176  1
2011 Lee HP, Kudo W, Zhu X, Smith MA, Lee HG. Early induction of c-Myc is associated with neuronal cell death. Neuroscience Letters. 505: 124-7. PMID 22005580 DOI: 10.1016/j.neulet.2011.10.004  0.8
2011 Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 1777-86. PMID 21968813 DOI: 10.1038/labinvest.2011.149  1
2011 Song B, Davis K, Liu XS, Lee HG, Smith M, Liu X. Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease. Aging. 3: 846-51. PMID 21931181  1
2011 Castellani RJ, Petersen RB, Lee HG, Zhu X, Perry G. Mark A. Smith: the scientist, the man. International Journal of Experimental Pathology. 92: 297-8. PMID 21917030 DOI: 10.1111/j.1365-2613.2011.00785.x  1
2011 Bonda DJ, Smith MA, Perry G, Lee HG, Wang X, Zhu X. The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention. Current Pharmaceutical Design. 17: 3374-80. PMID 21902671 DOI: 10.2174/138161211798072562  1
2011 Wolfram JA, Lesnefsky EJ, Hoit BD, Smith MA, Lee HG. Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy. Therapeutic Advances in Chronic Disease. 2: 133-44. PMID 21858245 DOI: 10.1177/2040622310393059  1
2011 Wolfram JA, Liner A, Richardson SL, Zhu X, Smith MA, Hoit BD, Lee HG. The role of E2F1 in the development of hypertrophic cardiomyopathy. International Journal of Clinical and Experimental Pathology. 4: 521-5. PMID 21738823  1
2011 Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. Journal of Neuropathology and Experimental Neurology. 70: 578-87. PMID 21666500 DOI: 10.1097/NEN.0b013e3182204414  1
2011 Moh C, Kubiak JZ, Bajic VP, Zhu X, Smith MA, Lee HG. Cell cycle deregulation in the neurons of Alzheimer's disease. Results and Problems in Cell Differentiation. 53: 565-76. PMID 21630160 DOI: 10.1007/978-3-642-19065-0_23  1
2011 Bajić VP, Su B, Lee HG, Kudo W, Siedlak SL, Zivković L, Spremo-Potparević B, Djelic N, Milicevic Z, Singh AK, Fahmy LM, Wang X, Smith MA, Zhu X. Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease. Cellular & Molecular Biology Letters. 16: 359-72. PMID 21461981 DOI: 10.2478/s11658-011-0011-2  1
2011 Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, ... ... Lee HG, et al. Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of Biological Chemistry. 286: 15095-105. PMID 21393248 DOI: 10.1074/jbc.M110.199356  1
2011 Chang KH, Multani PS, Sun KH, Vincent F, de Pablo Y, Ghosh S, Gupta R, Lee HP, Lee HG, Smith MA, Shah K. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Molecular Biology of the Cell. 22: 1452-62. PMID 21389115 DOI: 10.1091/mbc.E10-07-0654  0.8
2011 Bonda DJ, Lee HG, Camins A, Pallàs M, Casadesus G, Smith MA, Zhu X. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. The Lancet. Neurology. 10: 275-9. PMID 21349442 DOI: 10.1016/S1474-4422(11)70013-8  1
2011 Bonda DJ, Lee HG, Blair JA, Zhu X, Perry G, Smith MA. Role of metal dyshomeostasis in Alzheimer's disease. Metallomics : Integrated Biometal Science. 3: 267-70. PMID 21298161 DOI: 10.1039/c0mt00074d  1
2011 Castellani RJ, Nugent SL, Morrison AL, Zhu X, Lee HG, Harris PL, Bajić V, Sharma HS, Chen SG, Oettgen P, Perry G, Smith MA. CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 23-6. PMID 20972807 DOI: 10.1007/s00702-010-0485-5  1
2010 Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Casadesus G, Smith MA, Lee HG, Perry G. Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. International Journal of Biomedical Science : Ijbs. 6: 225-227. PMID 21765811  0.8
2010 Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Report : Communications in Free Radical Research. 15: 161-8. PMID 20663292 DOI: 10.1179/174329210X12650506623645  1
2010 Moreira PI, Santos RX, Zhu X, Lee HG, Smith MA, Casadesus G, Perry G. Autophagy in Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1209-18. PMID 20586699 DOI: 10.1586/ern.10.84  1
2010 Lee HP, Zhu X, Casadesus G, Castellani RJ, Nunomura A, Smith MA, Lee HG, Perry G. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1201-8. PMID 20586698 DOI: 10.1586/ern.10.74  0.8
2010 Bonda DJ, Lee HP, Kudo W, Zhu X, Smith MA, Lee HG. Pathological implications of cell cycle re-entry in Alzheimer disease. Expert Reviews in Molecular Medicine. 12: e19. PMID 20584423 DOI: 10.1017/S146239941000150X  0.68
2010 Mondragón-Rodríguez S, Basurto-Islas G, Lee HG, Perry G, Zhu X, Castellani RJ, Smith MA. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis. Expert Review of Neurotherapeutics. 10: 683-91. PMID 20420489 DOI: 10.1586/ern.10.27  1
2010 Gustaw-Rothenberg K, Lerner A, Bonda DJ, Lee HG, Zhu X, Perry G, Smith MA. Biomarkers in Alzheimer's disease: past, present and future. Biomarkers in Medicine. 4: 15-26. PMID 20387301 DOI: 10.2217/bmm.09.86  1
2010 Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 574-9. PMID 20374499 DOI: 10.1111/j.1440-1789.2010.01107.x  1
2010 Lee HP, Zhu X, Liu G, Chen SG, Perry G, Smith MA, Lee HG. Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship. Cell Research. 20: 397-9. PMID 20357807 DOI: 10.1038/cr.2010.39  0.8
2010 Chang KH, de Pablo Y, Lee HP, Lee HG, Smith MA, Shah K. Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease. Journal of Neurochemistry. 113: 1221-9. PMID 20345761 DOI: 10.1111/j.1471-4159.2010.06687.x  0.8
2010 Suszynska J, Tisonczyk J, Lee HG, Smith MA, Jakubowski H. Reduced homocysteine-thiolactonase activity in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1177-83. PMID 20308784 DOI: 10.3233/JAD-2010-1311  1
2010 Bonda DJ, Lee HP, Lee HG, Friedlich AL, Perry G, Zhu X, Smith MA. Novel therapeutics for Alzheimer's disease: an update. Current Opinion in Drug Discovery & Development. 13: 235-46. PMID 20205057  0.8
2010 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/j.nbd.2009.12.012  1
2010 Tabaton M, Perry G, Zhu X, Lee HG, Casadesus G, Smith MA. Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease. The American Journal of Pathology. 176: 540-1. PMID 20019185 DOI: 10.2353/ajpath.2010.090856  1
2010 Bryan KJ, Mudd JC, Richardson SL, Chang J, Lee HG, Zhu X, Smith MA, Casadesus G. Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits. Journal of Neurochemistry. 112: 870-81. PMID 19943850 DOI: 10.1111/j.1471-4159.2009.06502.x  1
2010 Su B, Wang X, Lee HG, Tabaton M, Perry G, Smith MA, Zhu X. Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells. Neuroscience Letters. 468: 267-71. PMID 19914335 DOI: 10.1016/j.neulet.2009.11.010  1
2010 Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA. Mitochondria: a therapeutic target in neurodegeneration. Biochimica Et Biophysica Acta. 1802: 212-20. PMID 19853657 DOI: 10.1016/j.bbadis.2009.10.007  1
2009 Cardoso S, Santos R, Correia S, Carvalho C, Zhu X, Lee HG, Casadesus G, Smith MA, Perry G, Moreira PI. Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets. Pharmaceuticals (Basel, Switzerland). 2: 250-286. PMID 27713238 DOI: 10.3390/ph2030250  1
2009 Rolston RK, Perry G, Zhu X, Castellani RJ, Dwyer BE, Lee HG, Petersen RB, Smith MA. Iron: A Pathological Mediator of Alzheimer Disease? Agro Food Industry Hi-Tech. 19: 33-36. PMID 21544251  1
2009 Friedlich AL, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA. Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Medicine Reports. 1. PMID 20948726 DOI: 10.3410/M1-54  1
2009 Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging. 1: 382-8. PMID 19946466  1
2009 Lee HP, Casadesus G, Zhu X, Lee HG, Perry G, Smith MA, Gustaw-Rothenberg K, Lerner A. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Review of Neurotherapeutics. 9: 1615-21. PMID 19903021 DOI: 10.1586/ern.09.86  0.8
2009 Snape M, Lee HG, Casadesus G, Smith MA. Cell cycle aberrations in Alzheimer's disease: a novel therapeutic opportunity. Expert Review of Neurotherapeutics. 9: 1579-80. PMID 19903017 DOI: 10.1586/ern.09.113  1
2009 Lee HG, Chen Q, Wolfram JA, Richardson SL, Liner A, Siedlak SL, Zhu X, Ziats NP, Fujioka H, Felsher DW, Castellani RJ, Valencik ML, McDonald JA, Hoit BD, Lesnefsky EJ, et al. Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. Plos One. 4: e7172. PMID 19779629 DOI: 10.1371/journal.pone.0007172  1
2009 Sun KH, Lee HG, Smith MA, Shah K. Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease. Molecular Biology of the Cell. 20: 4611-9. PMID 19776350 DOI: 10.1091/mbc.E09-05-0433  1
2009 Bajić VP, Spremo-Potparević B, Zivković L, Bonda DJ, Siedlak SL, Casadesus G, Lee HG, Smith MA. The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging? Medical Hypotheses. 73: 917-20. PMID 19647374 DOI: 10.1016/j.mehy.2009.06.046  1
2009 Su B, Liu H, Wang X, Chen SG, Siedlak SL, Kondo E, Choi R, Takeda A, Castellani RJ, Perry G, Smith MA, Zhu X, Lee HG. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease. Molecular Neurodegeneration. 4: 32. PMID 19627592 DOI: 10.1186/1750-1326-4-32  1
2009 Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9090-103. PMID 19605646 DOI: 10.1523/JNEUROSCI.1357-09.2009  1
2009 Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. Journal of Alzheimer's Disease : Jad. 18: 447-52. PMID 19584435 DOI: 10.3233/JAD-2009-1151  1
2009 Casley CS, Lakics V, Lee HG, Broad LM, Day TA, Cluett T, Smith MA, O'Neill MJ, Kingston AE. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. Brain Research. 1260: 65-75. PMID 19401173 DOI: 10.1016/j.brainres.2008.12.082  1
2009 Castellani RJ, Zhu X, Lee HG, Smith MA, Perry G. Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. International Journal of Molecular Sciences. 10: 1386-406. PMID 19399255 DOI: 10.3390/ijms10031386  1
2009 Lee HP, Zhu X, Zhu X, Skidmore SC, Perry G, Sayre LM, Smith MA, Lee HG. The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells. Journal of Neurochemistry. 108: 1434-41. PMID 19183271 DOI: 10.1111/j.1471-4159.2009.05883.x  0.8
2009 Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American Journal of Pathology. 174: 891-7. PMID 19164506 DOI: 10.2353/ajpath.2009.080583  1
2009 Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochemistry International. 54: 84-8. PMID 19114068 DOI: 10.1016/j.neuint.2008.10.013  1
2009 Stone JG, Rolston RK, Ueda M, Lee HG, Richardson SL, Castellani RJ, Perry G, Smith MA. Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain. International Journal of Clinical and Experimental Pathology. 2: 267-74. PMID 19079621  1
2009 Ramiro-Puig E, Casadesús G, Lee HG, Zhu X, McShea A, Perry G, Pérez-Cano FJ, Smith MA, Castell M. Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. European Journal of Nutrition. 48: 54-61. PMID 19043659 DOI: 10.1007/s00394-008-0761-4  1
2009 Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Research. 1249: 244-50. PMID 19026996 DOI: 10.1016/j.brainres.2008.10.055  1
2008 Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordrecht, Netherlands). 30: 209-15. PMID 19424844 DOI: 10.1007/s11357-008-9050-7  1
2008 Pallas M, Camins A, Smith MA, Perry G, Lee HG, Casadesus G. From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). Journal of Alzheimer's Disease : Jad. 15: 615-24. PMID 19096160  1
2008 Perry G, Castellani RJ, Moreira PI, Lee HG, Zhu X, Smith MA. Pathology's new role: defining disease process and protective responses. International Journal of Clinical and Experimental Pathology. 1: 1-4. PMID 18784818  1
2008 Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. International Journal of Clinical and Experimental Pathology. 1: 134-46. PMID 18784806  1
2008 Castellani RJ, Nunomura A, Lee HG, Perry G, Smith MA. Phosphorylated tau: toxic, protective, or none of the above. Journal of Alzheimer's Disease : Jad. 14: 377-83. PMID 18688087  1
2008 Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA. Alzheimer disease pathology as a host response. Journal of Neuropathology and Experimental Neurology. 67: 523-31. PMID 18520771 DOI: 10.1097/NEN.0b013e318177eaf4  1
2008 Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA. Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of Neurochemistry. 106: 1350-6. PMID 18485104 DOI: 10.1111/j.1471-4159.2008.05477.x  1
2008 Shah RS, Lee HG, Xiongwei Z, Perry G, Smith MA, Castellani RJ. Current approaches in the treatment of Alzheimer's disease. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 62: 199-207. PMID 18407457 DOI: 10.1016/j.biopha.2008.02.005  1
2007 Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X. Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 11: 143-52. PMID 17522439  1
2007 Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA. BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. International Journal of Medical Sciences. 4: 140-5. PMID 17505559  1
2007 Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Review of Neurotherapeutics. 7: 473-85. PMID 17492899 DOI: 10.1586/14737175.7.5.473  1
2007 Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. The Journal of Pharmacology and Experimental Therapeutics. 321: 823-9. PMID 17229880 DOI: 10.1124/jpet.106.114009  1
2007 Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: an update. Biochimica Et Biophysica Acta. 1772: 494-502. PMID 17142016 DOI: 10.1016/j.bbadis.2006.10.014  1
2007 McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA. Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica Et Biophysica Acta. 1772: 467-72. PMID 17095196 DOI: 10.1016/j.bbadis.2006.09.010  1
2006 Smith MA, Zhu X, Lee HG, Harris PL, Fortino AE, Perry G, Castellani RJ. Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy. Age (Dordrecht, Netherlands). 28: 85-91. PMID 23598681 DOI: 10.1007/s11357-006-9001-0  1
2006 McShea A, Marlatt MW, Lee HG, Tarkowsky SM, Smit M, Smith MA. The application of microarray technology to neuropathology: cutting edge tool with clinical diagnostics potential or too much information? Journal of Neuropathology and Experimental Neurology. 65: 1031-9. PMID 17086099 DOI: 10.1097/01.jnen.0000240471.04920.3c  1
2006 Lee HG, Ueda M, Miyamoto Y, Yoneda Y, Perry G, Smith MA, Zhu X. Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease. Brain Research. 1124: 1-4. PMID 17070506 DOI: 10.1016/j.brainres.2006.09.084  1
2006 Lee HG, Ueda M, Zhu X, Perry G, Smith MA. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? Journal of Neuroscience Research. 84: 1856-61. PMID 16998902 DOI: 10.1002/jnr.21072  1
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! The American Journal of Pathology. 169: 738-9. PMID 16936250 DOI: 10.2353/ajpath.2006.060633  1
2006 Lee HG, Perry G, Zhu X, Nunomura A, Smith MA. Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression". Free Radical Biology & Medicine. 41: 188-9. PMID 16814097 DOI: 10.1016/j.freeradbiomed.2006.03.014  1
2006 Lee HG, Zhu X, Takeda A, Perry G, Smith MA. Emerging evidence for the neuroprotective role of alpha-synuclein. Experimental Neurology. 200: 1-7. PMID 16780837 DOI: 10.1016/j.expneurol.2006.04.024  1
2006 Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathologica. 111: 503-9. PMID 16718346 DOI: 10.1007/s00401-006-0071-y  1
2006 Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Science of Aging Knowledge Environment : Sage Ke. 2006: pe10. PMID 16672726 DOI: 10.1126/sageke.2006.8.pe10  1
2006 Castellani RJ, Lee HG, Perry G, Smith MA. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. American Journal of Alzheimer's Disease and Other Dementias. 21: 126-30. PMID 16634469 DOI: 10.1177/153331750602100213  1
2006 Lee HG, Zhu X, Perry G, Smith MA. The fallacy of amyloid and cognition in Alzheimer's disease. Drugs & Aging. 23: 179. PMID 16536639  1
2006 Zhu X, Lee HG, Moreira PI, Smith MA, Perry G. Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice". Free Radical Biology & Medicine. 40: 737-9. PMID 16520226 DOI: 10.1016/j.freeradbiomed.2005.12.028  1
2006 Moreira PI, Zhu X, Lee HG, Honda K, Smith MA, Perry G. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease. Mechanisms of Ageing and Development. 127: 501-6. PMID 16516950 DOI: 10.1016/j.mad.2006.01.024  1
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid beta: the alternate hypothesis. Current Alzheimer Research. 3: 75-80. PMID 16472207 DOI: 10.2174/156720506775697124  1
2005 Zhu X, Mei M, Lee HG, Wang Y, Han J, Perry G, Smith MA. P38 activation mediates amyloid-beta cytotoxicity. Neurochemical Research. 30: 791-6. PMID 16187214 DOI: 10.1007/s11064-005-6872-x  1
2005 Lin D, Lee HG, Liu Q, Perry G, Smith MA, Sayre LM. 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 18: 1219-31. PMID 16097795 DOI: 10.1021/tx050080q  1
2005 Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, et al. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathologica. 110: 232-8. PMID 16096758 DOI: 10.1007/s00401-005-1034-4  1
2005 Zhu X, Lee HG, Casadesus G, Avila J, Drew K, Perry G, Smith MA. Oxidative imbalance in Alzheimer's disease. Molecular Neurobiology. 31: 205-17. PMID 15953822 DOI: 10.1385/MN:31:1-3:205  1
2005 Lee HG, Castellani RJ, Zhu X, Perry G, Smith MA. Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective? International Journal of Experimental Pathology. 86: 133-8. PMID 15910547 DOI: 10.1111/j.0959-9673.2005.00429.x  1
2005 Marlatt MW, Webber KM, Moreira PI, Lee HG, Casadesus G, Honda K, Zhu X, Perry G, Smith MA. Therapeutic opportunities in Alzheimer disease: one for all or all for one? Current Medicinal Chemistry. 12: 1137-47. PMID 15892629 DOI: 10.2174/0929867053764644  1
2005 Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in Molecular Medicine. 11: 164-9. PMID 15823754 DOI: 10.1016/j.molmed.2005.02.008  1
2005 Moreira PI, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, Perry G. Oxidative damage and Alzheimer's disease: are antioxidant therapies useful? Drug News & Perspectives. 18: 13-9. PMID 15753972 DOI: 10.1358/dnp.2005.18.1.877164  1
2005 Smith MA, Nunomura A, Lee HG, Zhu X, Moreira PI, Avila J, Perry G. Chronological primacy of oxidative stress in Alzheimer disease. Neurobiology of Aging. 26: 579-80. PMID 15708430 DOI: 10.1016/j.neurobiolaging.2004.09.021  1
2005 Webber KM, Smith MA, Lee HG, Harris PL, Moreira P, Perry G, Zhu X. Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease. Journal of Neuroscience Research. 79: 554-60. PMID 15635602 DOI: 10.1002/jnr.20380  1
2005 Liu Q, Lee HG, Honda K, Siedlak SL, Harris PL, Cash AD, Zhu X, Avila J, Nunomura A, Takeda A, Smith MA, Perry G. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 211-5. PMID 15615639 DOI: 10.1016/j.bbadis.2004.06.021  1
2004 Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience. 7: 309-16. PMID 15682927 DOI: 10.1080/10284150400020482  1
2004 Lee HG, Moreira PI, Zhu X, Smith MA, Perry G. Staying connected: synapses in Alzheimer disease. The American Journal of Pathology. 165: 1461-4. PMID 15509517 DOI: 10.1016/S0002-9440(10)63404-9  1
2004 Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA. Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Annals of the New York Academy of Sciences. 1019: 1-4. PMID 15246983 DOI: 10.1196/annals.1297.001  1
2004 Lee HG, Zhu X, O'Neill MJ, Webber K, Casadesus G, Marlatt M, Raina AK, Perry G, Smith MA. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 89-98. PMID 15190683  1
2004 Marlatt M, Lee HG, Perry G, Smith MA, Zhu X. Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease. Acta Neurobiologiae Experimentalis. 64: 81-7. PMID 15190682  1
2004 Robinson SR, Bishop GM, Lee HG, Münch G. Lessons from the AN 1792 Alzheimer vaccine: lest we forget. Neurobiology of Aging. 25: 609-15. PMID 15172738 DOI: 10.1016/j.neurobiolaging.2003.12.020  1
2004 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/j.1471-4159.2004.02416.x  1
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