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Year Citation  Score
2023 Xu J, Lv YT, Zhao XY, Wang JJ, Shen ZS, Li J, Zhang FF, Liu J, Wang XH, Xu Y, Geng Q, Ding YT, Xu JJ, Tan MJ, Li ZX, ... ... Logothetis DE, et al. Identification of sodium- and chloride-sensitive sites in the Slack channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36898835 DOI: 10.1523/JNEUROSCI.1365-22.2023  0.462
2022 Gada KD, Chang M, Chandrashekar A, Plant LD, Noujaim SF, Logothetis DE. Mechanism of PKCε regulation of cardiac GIRK channel gating. Proceedings of the National Academy of Sciences of the United States of America. 120: e2212325120. PMID 36584301 DOI: 10.1073/pnas.2212325120  0.482
2022 Chidipi B, Chang M, Cui M, Abou-Assali O, Reiser M, Pshenychnyi S, Logothetis DE, Teng MN, Noujaim SF. Bioengineered peptibodies as blockers of ion channels. Proceedings of the National Academy of Sciences of the United States of America. 119: e2212564119. PMID 36475947 DOI: 10.1073/pnas.2212564119  0.446
2022 Gazgalis D, Cantwell L, Xu Y, Thakur GA, Cui M, Guarnieri F, Logothetis DE. Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism. International Journal of Molecular Sciences. 23. PMID 36142730 DOI: 10.3390/ijms231810820  0.451
2022 Gada KD, Logothetis DE. PKC regulation of ion channels: The involvement of PIP. The Journal of Biological Chemistry. 298: 102035. PMID 35588786 DOI: 10.1016/j.jbc.2022.102035  0.488
2022 Cui M, Xu K, Gada K, Shalomov B, Ban M, Eptaminitaki GC, Kawano T, Plant LD, Dascal N, Logothetis DE. A novel small molecule selective activator of homomeric GIRK4 channels. The Journal of Biological Chemistry. 102009. PMID 35525275 DOI: 10.1016/j.jbc.2022.102009  0.505
2022 Corradi V, Bukiya AN, Miranda WE, Cui M, Plant LD, Logothetis DE, Tieleman DP, Noskov SY, Rosenhouse-Dantsker A. A molecular switch controls the impact of cholesterol on a Kir channel. Proceedings of the National Academy of Sciences of the United States of America. 119: e2109431119. PMID 35333652 DOI: 10.1073/pnas.2109431119  0.454
2021 Cui M, Cantwell L, Zorn A, Logothetis DE. Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications. Handbook of Experimental Pharmacology. PMID 34345939 DOI: 10.1007/164_2021_501  0.404
2021 Ningoo M, Plant LD, Greka A, Logothetis DE. PIP regulation of TRPC5 channel activation and desensitization. The Journal of Biological Chemistry. 100726. PMID 33933453 DOI: 10.1016/j.jbc.2021.100726  0.769
2021 Cui M, Alhamshari Y, Cantwell L, Ei-Haou S, Eptaminitaki GC, Chang M, Abou-Assali O, Tan H, Xu K, Masotti M, Plant LD, Thakur GA, Noujaim SF, Milnes J, Logothetis DE. A benzopyran with anti-arrhythmic activity is an inhibitor of Kir3.1-containing potassium channels. The Journal of Biological Chemistry. 100535. PMID 33713702 DOI: 10.1016/j.jbc.2021.100535  0.458
2020 Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA. The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents. The Journal of Biological Chemistry. PMID 31953327 DOI: 10.1074/Jbc.Ra119.011527  0.496
2020 Xu Y, Xiang G, Kawano T, Logothetis DE. Functional Relevance of Orthosteric Binding Site of 5-Hydroxytryptamine 2A Receptor and the Mechanism of Receptor Activation Biophysical Journal. 118: 93a. DOI: 10.1016/J.Bpj.2019.11.671  0.327
2020 Chandrashekar A, Gada K, Xu Y, Kawano T, Plant LD, Logothetis DE. Modulation of a GIRK1 Active Mutant Subunit by Protein Kinase C Isoforms Biophysical Journal. 118: 418a. DOI: 10.1016/J.Bpj.2019.11.2360  0.353
2020 Gada K, Chandrashekar A, Xu Y, Kawano T, Plant LD, Logothetis DE. Modulation of GIRK Channels by Protein Kinase C and its Role in Atrial Fibrillation Biophysical Journal. 118: 324a-325a. DOI: 10.1016/J.Bpj.2019.11.1822  0.47
2019 Li D, Jin T, Gazgalis D, Cui M, Logothetis DE. On the mechanism of the GIRK2 channel gating by phosphatidylinositol bisphosphate (PIP2), sodium, and the Gβγ dimer. The Journal of Biological Chemistry. PMID 31659119 DOI: 10.1074/Jbc.Ra119.010047  0.746
2019 Gada K, Xu Y, Kawano T, Plant LD, Logothetis DE. Modulation of GIRK Channels by Protein Kinase C Biophysical Journal. 116: 401a. DOI: 10.1016/J.Bpj.2018.11.2165  0.494
2019 Xiang G, Baki L, Kawano T, Logothetis D. Modulation of Mu-Opioid Receptor Signaling by Cannabinoid CB1 Receptor through Heteromerization, a Novel Analgesic Target Biophysical Journal. 116: 234a. DOI: 10.1016/J.Bpj.2018.11.1287  0.302
2019 Villalba-Galea CA, Kawano T, Logothetis DE. C-Type Inactivation in KV2.1 Channels Biophysical Journal. 116: 15a. DOI: 10.1016/J.Bpj.2018.11.122  0.505
2018 Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andrés F, Brezina V. Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification. Plos Computational Biology. 14: e1006539. PMID 30325915 DOI: 10.1371/Journal.Pcbi.1006539  0.6
2018 Delgado-Ramírez M, De Jesús-Pérez JJ, Aréchiga-Figueroa IA, Arreola J, Adney SK, Villalba-Galea CA, Logothetis DE, Rodríguez-Menchaca AA. Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate. Scientific Reports. 8: 1769. PMID 29379118 DOI: 10.1038/S41598-018-20280-W  0.61
2018 Ha J, Xu Y, Kawano T, Hendon T, Baki L, Garai S, Papapetropoulos A, Thakur G, Plant LD, Logothetis DE. Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid PIP2. The Journal of Biological Chemistry. PMID 29317494 DOI: 10.1074/Jbc.Ra117.001679  0.58
2017 Gu Z, Plant LD, Meng X, Perez-Aguilar JM, Wang Z, Dong M, Logothetis DE, Zhou R. Exploring the Nanotoxicology of MoS2: A Study on the Interaction of MoS2 Nanoflake and K+ Channels. Acs Nano. PMID 29236481 DOI: 10.1021/acsnano.7b07871  0.482
2017 Tobelaim WS, Dvir M, Lebel G, Cui M, Buki T, Peretz A, Marom M, Haitin Y, Logothetis DE, Hirsch JA, Attali B. Ca(2+)-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels. Channels (Austin, Tex.). 0. PMID 28976808 DOI: 10.1080/19336950.2017.1388478  0.509
2017 Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andrés F, Brezina V. Elucidation of molecular kinetic schemes from macroscopic traces using system identification. Plos Computational Biology. 13: e1005376. PMID 28192423 DOI: 10.1371/Journal.Pcbi.1005376  0.685
2017 Tobelaim WS, Dvir M, Lebel G, Cui M, Buki T, Peretz A, Marom M, Haitin Y, Logothetis DE, Hirsch JA, Attali B. Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096388 DOI: 10.1073/Pnas.1612622114  0.554
2017 Ren S, Li J, Zhang S, Logothetis DE, An H, Zhan Y. E224G Regulation of the PIP 2 -Induced Gating Kinetics of Kir2.1 Channels Chinese Physics Letters. 34: 016102. DOI: 10.1088/0256-307X/34/1/016102  0.571
2017 Xiang G, Kawano T, Baki A, Logothetis D. Decoding the Signaling through Homomeric and Heteromeric Cannabinoid CB1 Receptors Biophysical Journal. 112: 88a. DOI: 10.1016/J.Bpj.2016.11.518  0.321
2017 Xu Y, Ellaithy A, Kawano T, Gonzalez-Maeso J, Logothetis D. Ionic Lock: Functional Role in Activation of Metabotropic Glutamate Receptor 2 Biophysical Journal. 112: 530a. DOI: 10.1016/J.Bpj.2016.11.2868  0.351
2017 Tang Q, Liu Y, Xu Z, Zhang F, Zhang F, Li Y, Eltit JM, Logothetis DE, Zhang Z. Slo3 Channel is Essential for Fertilized Egg Development by Controlling Critical Molecules for Mitosis Biophysical Journal. 112: 405a. DOI: 10.1016/J.Bpj.2016.11.2192  0.338
2017 Xu Y, Kawano T, Ha J, Garai S, Xiang G, Thakur G, Logothetis DE. Mechanism of Action of a Small Molecule Activator of Phosphoinositide-Dependent GIRK Channels Biophysical Journal. 112: 254a. DOI: 10.1016/J.Bpj.2016.11.1385  0.517
2017 Ha J, Xu Y, Hendon T, Kawano T, Garai S, Thakur G, Papapetropoulos A, Logothetis DE. Hydrogen Sulfide (H 2 S) Regulation of Kir (Inwardly Rectifying K+) Channels Biophysical Journal. 112: 226a-227a. DOI: 10.1016/J.Bpj.2016.11.1248  0.56
2016 Li JW, Xiao SY, Xie XX, Zhou H, Pang CL, Li SS, Zhang HL, Logothetis DE, Zhan Y, An HL. Three pairs of Weak interactions precisely regulate the G-loop gate of Kir2.1 Channel. Proteins. PMID 27699887 DOI: 10.1002/Prot.25176  0.407
2016 Meng XY, Liu S, Cui M, Zhou R, Logothetis DE. The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel. Scientific Reports. 6: 29399. PMID 27439597 DOI: 10.1038/Srep29399  0.518
2016 Deng W, Mahajan R, Baumgarten CM, Logothetis DE. The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2. Pflugers Archiv : European Journal of Physiology. PMID 26837888 DOI: 10.1007/S00424-016-1794-9  0.605
2016 Baki L, Fribourg M, Younkin J, Eltit JM, Moreno JL, Park G, Vysotskaya Z, Narahari A, Sealfon SC, Gonzalez-Maeso J, Logothetis DE. Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells. Pflugers Archiv : European Journal of Physiology. PMID 26780666 DOI: 10.1007/S00424-015-1780-7  0.708
2016 Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, ... ... Logothetis DE, et al. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science Signaling. 9: ra5. PMID 26758213 DOI: 10.1126/Scisignal.Aab0467  0.375
2016 Xu Y, Ellaithy A, Xiang G, Danai M, Agisilaos B, Kawano T, Cui M, Logothetis DE. Positive Allosteric Modulators Induced Conformational Changes in the Metabotropic Glutamate Receptor 2 - In Silico Predictions and Experimental Tests Biophysical Journal. 110: 90a. DOI: 10.1016/J.Bpj.2015.11.541  0.392
2016 Xiang G, Kawano T, Baki L, Logothetis DE. Decoding the Signaling through Homomeric and Heteromeric Dopamine D2 and Cannabinioid CB1 Receptors Biophysical Journal. 110: 424a-425a. DOI: 10.1016/J.Bpj.2015.11.2295  0.384
2016 Tobelaim WS, Dvir M, Lebel G, Cui M, Buki T, Peretz A, Logothetis D, Hirsch J, Attali B. A Novel Site of Competitive PIP2 and Calmodulin Interaction to KCNQ1 C-Terminus Helix B is Crucial for IKs Channel Activity Biophysical Journal. 110: 186a. DOI: 10.1016/J.Bpj.2015.11.1037  0.42
2015 Tang QY, Zhang FF, Xu J, Wang R, Chen J, Logothetis DE, Zhang Z. Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms. Cell Reports. PMID 26725113 DOI: 10.1016/J.Celrep.2015.12.019  0.551
2015 Adney SK, Ha J, Meng XY, Kawano T, Logothetis DE. A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14397-405. PMID 26490875 DOI: 10.1523/Jneurosci.1415-15.2015  0.615
2015 Logothetis DE, Mahajan R, Adney SK, Ha J, Kawano T, Meng XY, Cui M. Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides. International Review of Neurobiology. 123: 1-26. PMID 26422981 DOI: 10.1016/Bs.Irn.2015.05.013  0.598
2015 Zhang M, Meng XY, Zhang JF, Cui M, Logothetis DE. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Science Advances. 1: e1500008. PMID 26366439 DOI: 10.1126/Sciadv.1500008  0.582
2015 Ellaithy A, Younkin J, González-Maeso J, Logothetis DE. Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment. Trends in Neurosciences. 38: 506-16. PMID 26148747 DOI: 10.1016/J.Tins.2015.06.002  0.312
2015 Li J, Lü S, Liu Y, Pang C, Chen Y, Zhang S, Yu H, Long M, Zhang H, Logothetis DE, Zhan Y, An H. Identification of the Conformational transition pathway in PIP2 Opening Kir Channels. Scientific Reports. 5: 11289. PMID 26063437 DOI: 10.1038/Srep11289  0.504
2015 Tang QY, Larry T, Hendra K, Yamamoto E, Bell J, Cui M, Logothetis DE, Boland LM. Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium Channels. The Journal of Biological Chemistry. 290: 16517-29. PMID 25957411 DOI: 10.1074/Jbc.M115.640409  0.584
2015 Mastorodemos V, Kanavouras K, Sundaram S, Providaki M, Petraki Z, Kokkinidis M, Zaganas I, Logothetis DE, Plaitakis A. Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation. Journal of Neurochemistry. 133: 73-82. PMID 25620628 DOI: 10.1111/Jnc.13019  0.357
2015 Logothetis DE, Petrou VI, Zhang M, Mahajan R, Meng XY, Adney SK, Cui M, Baki L. Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels. Annual Review of Physiology. 77: 81-104. PMID 25293526 DOI: 10.1146/Annurev-Physiol-021113-170358  0.795
2015 Younkin J, Baki L, Ellaithy A, Logothetis DE. Allosteric Effects of G-Protein Coupled Receptor Heteromerization: Relevance to Psychosis Biophysical Journal. 108: 95a. DOI: 10.1016/J.Bpj.2014.11.548  0.39
2015 Ellaithy A, Younkin J, Baki L, Logothetis D. A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor Alters 5-HT2A Receptor Signaling in a Heteromeric Complex Biophysical Journal. 108: 416a. DOI: 10.1016/J.Bpj.2014.11.2281  0.377
2015 Hatcher-Solis C, Logothetis DE. Pharmacological Implications of A2Ar-D2R Heteromerization and the Significance for Parkinson's Disease Biophysical Journal. 108: 416a. DOI: 10.1016/J.Bpj.2014.11.2278  0.393
2014 Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, Gonzalez-Maeso J, Zhang H, Cui M, Logothetis DE. G protein-coupled receptor signaling to Kir channels in Xenopus oocytes. Current Pharmaceutical Biotechnology. 15: 987-95. PMID 25374032 DOI: 10.2174/1389201015666141031111916  0.787
2014 Li J, Xie X, Liu J, Yu H, Zhang S, Zhan Y, Zhang H, Logothetis DE, An H. Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+. Plos One. 9: e111372. PMID 25350118 DOI: 10.1371/Journal.Pone.0111372  0.511
2014 Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF. Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nature Chemical Biology. 10: 753-9. PMID 25108821 DOI: 10.1038/Nchembio.1592  0.567
2014 Spyridaki K, Matsoukas MT, Cordomi A, Gkountelias K, Papadokostaki M, Mavromoustakos T, Logothetis DE, Margioris AN, Pardo L, Liapakis G. Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism. The Journal of Biological Chemistry. 289: 18966-77. PMID 24838244 DOI: 10.1074/Jbc.M113.544460  0.391
2014 Tang QY, Zhang Z, Meng XY, Cui M, Logothetis DE. Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site. The Journal of Biological Chemistry. 289: 18860-72. PMID 24778177 DOI: 10.1074/Jbc.M113.538033  0.548
2014 Baki L, Younkin J, Eltit JM, Fribourg M, Park G, Vysotskaya Z, Logothetis DE. Cross-Signaling between the Metabotropic Glutamate 2 Receptor and the Serotonin (5-Ht) 2A Receptor in Hek-293 Cells Biophysical Journal. 106: 103a. DOI: 10.1016/J.Bpj.2013.11.642  0.706
2014 Zhang M, Cui M, Meng X, Zhang J, Logothetis DE. Pip2-Channel Interaction as a Critical Element in Regulation of SK Channel Activity Biophysical Journal. 106: 749a. DOI: 10.1016/J.Bpj.2013.11.4127  0.622
2014 Tang Q, Zhang Z, Meng X, Cui M, Logothetis DE. Calcium and Pip2 Interplay Regulates BK Channel Activity via the RCK1 Gating Ring Biophysical Journal. 106: 749a. DOI: 10.1016/J.Bpj.2013.11.4126  0.558
2014 Rosenhouse-Dantsker A, Noskov S, Durdagi S, Logothetis DE, Levitan I. Identification of Novel Cholesterol Binding Regions in the Transmembrane Domain of Kir2.1 Biophysical Journal. 106: 747a. DOI: 10.1016/J.Bpj.2013.11.4117  0.466
2014 Leal-Pinto E, Ha J, Kawano T, Zhang M, Tang Q, Gomez-Llorente Y, Chavez J, Ubarretxena I, Logothetis DE. Requirement for an Activated G Protein α (Gα) Subunit for Gβγ Activation of a Purified Mammalian GIRk1 Channel Reconstituted in Planar Lipid Bilayers Biophysical Journal. 106: 747a. DOI: 10.1016/J.Bpj.2013.11.4115  0.538
2014 Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, Gonzalez-Maeso J, Zhang H, Cui M, Logothetis DE. G protein-coupled receptor signaling to kir channels in xenopus oocytes 1 Current Pharmaceutical Biotechnology. 15: 987-995.  0.441
2013 Rosenhouse-Dantsker A, Noskov S, Durdagi S, Logothetis DE, Levitan I. Identification of novel cholesterol-binding regions in Kir2 channels. The Journal of Biological Chemistry. 288: 31154-64. PMID 24019518 DOI: 10.1074/Jbc.M113.496117  0.719
2013 Mahajan R, Ha J, Zhang M, Kawano T, Kozasa T, Logothetis DE. A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels. Science Signaling. 6: ra69. PMID 23943609 DOI: 10.1126/Scisignal.2004075  0.552
2013 Rosenhouse-Dantsker A, Noskov S, Logothetis DE, Levitan I. Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini. Channels (Austin, Tex.). 7: 303-12. PMID 23807091 DOI: 10.4161/Chan.25437  0.721
2013 Zhang Z, Tang QY, Alaimo JT, Davies AG, Bettinger JC, Logothetis DE. SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans. Channels (Austin, Tex.). 7: 194-205. PMID 23590941 DOI: 10.4161/Chan.24492  0.488
2013 Zhou L, Logothetis DE. The where and how of PIP regulation of cone photoreceptor CNG channels. The Journal of General Physiology. 141: 403-7. PMID 23530135 DOI: 10.1085/Jgp.201310981  0.542
2013 Logothetis DE, Mahajan R, VanHook AM. Science signaling podcast: 13 August 2013 Science Signaling. 6. DOI: 10.1126/Scisignal.2004566  0.473
2013 Adney SK, Meng X, Logothetis DE. Unique PIP2 Sensitivity at a Putative PKC Site in GIRK2 (Kir3.2) Biophysical Journal. 104: 130a. DOI: 10.1016/J.Bpj.2012.11.745  0.51
2013 Meng X, Cui M, Logothetis DE. Simulations of the Helix Bundle Crossing Gate Opening in Kir Channels Biophysical Journal. 104: 129a. DOI: 10.1016/J.Bpj.2012.11.740  0.528
2013 Baki L, Eltit JM, Fribourg M, Younkin J, Park G, Vysotskaya Z, Sealfon SC, Liapakis G, Gonzalez-Maeso J, Logothetis DE. Functional Crosstalk between mGluR2 and 5-HT2A Depends on their Expression Ratios Biophysical Journal. 104: 116a. DOI: 10.1016/J.Bpj.2012.11.671  0.715
2013 Younkin J, Logothetis DE. Functional Signaling Changes Resulting from GPCR Heteromerization: Relevance to Psychosis Biophysical Journal. 104: 115a-116a. DOI: 10.1016/J.Bpj.2012.11.669  0.358
2013 Hatcher CN, Liapakis G, Logothetis DE. Characterizing the Effect of A2AR-D2R Heteromeric Complex Formation on Homomeric A2AR and D2R Signaling Biophysical Journal. 104: 115a. DOI: 10.1016/J.Bpj.2012.11.667  0.351
2013 Rosenhouse-Dantsker A, Logothetis DE, Levitan I. Coupling between the N- and C- Termini of Kir2.1 is Critical for Cholesterol Modulation Biophysical Journal. 104: 440a. DOI: 10.1016/J.Bpj.2012.11.2444  0.575
2013 Mahajan R, Ha J, Logothetis DE. Structural Model of K+ Channel Activation by the Beta-Gamma Subunits of G-Proteins Biophysical Journal. 104: 409a. DOI: 10.1016/J.Bpj.2012.11.2279  0.562
2013 Tang Q, Zhang Z, Meng X, Cui M, Logothetis DE. Identification of a Novel PIP2 Interaction Site and its Allosteric Regulation by the RCK1 Site Associated with Ca2+ Coordination in Slo1 Channels Biophysical Journal. 104: 357a. DOI: 10.1016/J.Bpj.2012.11.1983  0.435
2013 Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang Q, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I. Distant Cytosolic Residues in Kir Channels Control Channel Gating and Modulation by Cholesterol and PI(4,5)P2 Biophysical Journal. 104: 24a-25a. DOI: 10.1016/J.Bpj.2012.11.169  0.84
2013 Sundaram S, Ho Yang C, Logothetis DE. Molecular Basis of the Blocking Mechanism of Inwardly Rectifying Channels by Tertiapin Biophysical Journal. 104: 237a. DOI: 10.1016/J.Bpj.2012.11.1340  0.576
2013 Logothetis DE. Regulation of K Channels by the G Protein Signaling System Biophysical Journal. 104: 6a. DOI: 10.1016/J.Bpj.2012.11.060  0.596
2012 Rodríguez-Menchaca AA, Adney SK, Zhou L, Logothetis DE. Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2). Frontiers in Pharmacology. 3: 170. PMID 23055973 DOI: 10.3389/Fphar.2012.00170  0.592
2012 An HL, Lü SQ, Li JW, Meng XY, Zhan Y, Cui M, Long M, Zhang HL, Logothetis DE. The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels. The Journal of Biological Chemistry. 287: 42278-87. PMID 23033482 DOI: 10.1074/Jbc.M112.418640  0.597
2012 Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I. Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). The Journal of Biological Chemistry. 287: 40266-78. PMID 22995912 DOI: 10.1074/Jbc.M111.336339  0.849
2012 Rodriguez-Menchaca AA, Adney SK, Tang QY, Meng XY, Rosenhouse-Dantsker A, Cui M, Logothetis DE. PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proceedings of the National Academy of Sciences of the United States of America. 109: E2399-408. PMID 22891352 DOI: 10.1073/Pnas.1207901109  0.504
2012 Meng XY, Zhang HX, Logothetis DE, Cui M. The molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel. Biophysical Journal. 102: 2049-59. PMID 22824268 DOI: 10.1016/J.Bpj.2012.03.050  0.533
2012 Wells GD, Tang QY, Heler R, Tompkins-MacDonald GJ, Pritchard EN, Leys SP, Logothetis DE, Boland LM. A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge. The Journal of Experimental Biology. 215: 2435-44. PMID 22723483 DOI: 10.1242/Jeb.066233  0.523
2012 Deng W, Bukiya AN, Rodríguez-Menchaca AA, Zhang Z, Baumgarten CM, Logothetis DE, Levitan I, Rosenhouse-Dantsker A. Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ. The Journal of Biological Chemistry. 287: 4925-35. PMID 22174416 DOI: 10.1074/Jbc.M111.306134  0.575
2012 Zhang Z, Tang Q, Logothetis DE. Cooperative Regulation of Slack Channel by Na+, Cl− and PIP2 Biophysical Journal. 102: 136a. DOI: 10.1016/J.Bpj.2011.11.753  0.591
2012 Petrou VI, Logothetis DE. Phosphoinositide Signaling Regulates the Surface Localization of the δ2 Ionotropic Glutamate Receptor Biophysical Journal. 102: 115a. DOI: 10.1016/J.Bpj.2011.11.646  0.773
2012 Deng W, Bukiya AN, Rodríguez-Menchaca AA, Zhang Z, Baumgarten CM, Logothetis DE, Levitan I, Rosenhouse-Dantsker A. Hypercholesterolemia Induces Upregulation of KACh Cardiac Currents Biophysical Journal. 102: 301a. DOI: 10.1016/J.Bpj.2011.11.1664  0.508
2012 Rosenhouse-Dantsker A, Noskov S, Rodríguez-Menchaca AA, Logothetis DE, Levitan I. Modulation of Kir Channels by Cholesterol and PI(4,5)P2 Is Controlled by a Two-Way Molecular Switch Biophysical Journal. 102: 18a. DOI: 10.1016/J.Bpj.2011.11.123  0.582
2011 Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, ... ... Logothetis DE, et al. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell. 147: 1011-23. PMID 22118459 DOI: 10.1016/J.Cell.2011.09.055  0.666
2011 Rosenhouse-Dantsker A, Logothetis DE, Levitan I. Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore. Biophysical Journal. 100: 381-9. PMID 21244834 DOI: 10.1016/J.Bpj.2010.11.086  0.713
2011 Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L. Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflã¼Gers Archiv : European Journal of Physiology. 461: 387-97. PMID 21107857 DOI: 10.1007/S00424-010-0904-3  0.807
2011 Rosenhouse-Dantsker A, Logothetis DE, Levitan I. Cholesterol Sensitivity of Kir2.1 is Modulated by a Cytosolic Belt: Implications for Kir Gating Biophysical Journal. 100: 99a. DOI: 10.1016/J.Bpj.2010.12.749  0.573
2011 Rodriguez-Menchaca AA, Adney SK, Logothetis DE. Dual Regulation of Kv1.2 Activation by PIP2 Biophysical Journal. 100: 98a. DOI: 10.1016/J.Bpj.2010.12.741  0.486
2011 Tang Q, Zhang Z, Petrou VI, Logothetis DE. An Epilepsy/Dyskinesia-Associated Mutation in BK Channel Enhanced Channel-PIP2 Apparent Affinity Biophysical Journal. 100: 582a-583a. DOI: 10.1016/J.Bpj.2010.12.3366  0.84
2011 Zhang Z, Tang Q, Logothetis DE. C. Elegans Slo-2b uses its RCK1 Domain as a Ca2+ Sensor and does not Exhibit Cl- Dependence Biophysical Journal. 100: 582a. DOI: 10.1016/J.Bpj.2010.12.3365  0.498
2011 Meng X, Zhang H, Logothetis DE, Cui M. Molecular Dynamics Simulations of PIP2-Driven Kir Channel Activation Biophysical Journal. 100: 431a. DOI: 10.1016/J.Bpj.2010.12.2548  0.56
2011 Leal-Pinto E, Gómez-Llorente Y, Sundaram S, Tang Q, Ivanova-Nikolova T, Mahajan R, Baki L, Zhang Z, Chavez J, Ubarretxena-Belandia I, Logothetis DE. G protein Gating of a Kir3.1-Prokaryotic Kir Channel Chimera Functionally Reconstituted in Planar Lipid Bilayers Biophysical Journal. 100: 430a. DOI: 10.1016/J.Bpj.2010.12.2541  0.609
2011 An H, Li J, Zhan Y, Zhang H, Logothetis DE. Flexibility Between the Linker of the CD and G-Loops Determines the Gating Dynamics of Hte Kir2.1 Channel Biophysical Journal. 100: 430a. DOI: 10.1016/J.Bpj.2010.12.2540  0.541
2011 Mahajan R, Logothetis DE. Functional Sites of Interaction Between G-Protein βγ Subunits and GIRK Channels Biophysical Journal. 100: 358a-359a. DOI: 10.1016/J.Bpj.2010.12.2150  0.58
2011 Petrou VI, Logothetis DE. The Lurcher Mutant of δ2 Ionotropic Glutamate Receptor is Regulated by Phosphoinositides Biophysical Journal. 100: 268a. DOI: 10.1016/J.Bpj.2010.12.1672  0.789
2011 Provasi D, Li Z, Shim J, Fribourg M, Moreno JL, Logothetis DE, Gonzalez-Maeso J, MacKerell AD, Filizola M. Metadynamics-Based Mechanistic Interpretation of Functional Crosstalk Between Serotonin 2A and Metabotropic Glutamate 2 receptors Biophysical Journal. 100: 255a. DOI: 10.1016/J.Bpj.2010.12.1611  0.661
2010 Styer AM, Mirshahi UL, Wang C, Girard L, Jin T, Logothetis DE, Mirshahi T. G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels. The Journal of Biological Chemistry. 285: 41290-9. PMID 21044958 DOI: 10.1074/Jbc.M110.178541  0.758
2010 Leal-Pinto E, Gómez-Llorente Y, Sundaram S, Tang QY, Ivanova-Nikolova T, Mahajan R, Baki L, Zhang Z, Chavez J, Ubarretxena-Belandia I, Logothetis DE. Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers. The Journal of Biological Chemistry. 285: 39790-800. PMID 20937804 DOI: 10.1074/Jbc.M110.151373  0.592
2010 Zhang Z, Rosenhouse-Dantsker A, Tang QY, Noskov S, Logothetis DE. The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7554-62. PMID 20519529 DOI: 10.1523/Jneurosci.0525-10.2010  0.549
2010 Logothetis DE, Petrou VI, Adney SK, Mahajan R. Channelopathies linked to plasma membrane phosphoinositides. PflüGers Archiv : European Journal of Physiology. 460: 321-41. PMID 20396900 DOI: 10.1007/S00424-010-0828-Y  0.838
2010 Tang QY, Zhang Z, Xia J, Ren D, Logothetis DE. Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition. The Journal of Biological Chemistry. 285: 19259-66. PMID 20392696 DOI: 10.1074/Jbc.M109.100156  0.752
2010 Rosenhouse-Dantsker A, Leal-Pinto E, Logothetis DE, Levitan I. Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop. Channels (Austin, Tex.). 4: 63-6. PMID 19923917 DOI: 10.4161/Chan.4.1.10366  0.713
2010 Fribourg M, Galocha-Iragüen B, Heras-Andrés FL, Logothetis DE, Brezina V. An analytical tool for elucidating ion-channel molecular mechanisms from macroscopic current traces Bmc Neuroscience. 11. DOI: 10.1186/1471-2202-11-S1-P149  0.751
2010 Leal-Pinto E, Gomez-Llorente Y, Sundaram S, Tang Q, Ubarretxena I, Logothetis DE. Functional Reconstitution of a GIRK1-Chimera and its Regulation by the βγ Subunits of G Proteins Biophysical Journal. 98: 700a-701a. DOI: 10.1016/J.Bpj.2009.12.3844  0.533
2010 Zhang Z, Rosenhouse-Dantsker A, Tang Q, Noskov S, Logothetis DE. The Na+-Activated Potassium Channel Slack Shares a Similar Na+ Coordination Site with Kir3 Channels Biophysical Journal. 98: 533a-534a. DOI: 10.1016/J.Bpj.2009.12.2895  0.543
2010 Rosenhouse-Dantsker A, Leal-Pinto E, Logothetis DE, Levitan I. Comparative Analysis of Cholesterol Sensitivity of Kir Channels: Role of the Cytoplasmic Domain Biophysical Journal. 98: 213a. DOI: 10.1016/J.Bpj.2009.12.1147  0.561
2009 Mo G, Bernier LP, Zhao Q, Chabot-Doré AJ, Ase AR, Logothetis D, Cao CQ, Séguéla P. Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors. Molecular Pain. 5: 47. PMID 19671169 DOI: 10.1186/1744-8069-5-47  0.491
2009 Geng X, Du XN, Rusinova R, Liu BY, Li F, Zhang X, Chen XJ, Logothetis DE, Zhang HL. Specificity of Gbetagamma signaling depends on Galpha subunit coupling with G-protein-sensitive K(+) channels. Pharmacology. 84: 82-90. PMID 19590257 DOI: 10.1159/000227772  0.795
2009 Epshtein Y, Chopra AP, Rosenhouse-Dantsker A, Kowalsky GB, Logothetis DE, Levitan I. Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol. Proceedings of the National Academy of Sciences of the United States of America. 106: 8055-60. PMID 19416905 DOI: 10.1073/Pnas.0809847106  0.66
2009 Rusinova R, Shen YM, Dolios G, Padovan J, Yang H, Kirchberger M, Wang R, Logothetis DE. Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit. PflüGers Archiv : European Journal of Physiology. 458: 303-14. PMID 19151997 DOI: 10.1007/S00424-008-0628-9  0.756
2009 Fribourg-Casajuana M, González-Maeso J, Sealfon SC, Logothetis DE. Functional Evidence for Gi-Gq crosstalk through G protein-coupled Receptor Heterocomplexes Biophysical Journal. 96: 674a-675a. DOI: 10.1016/J.Bpj.2008.12.3565  0.431
2009 Petrou VI, Logothetis DE. A Mutant δ2 Ionotropic Glutamate Receptor Exhibits Dual Regulation by Phosphoinositides Biophysical Journal. 96: 489a. DOI: 10.1016/J.Bpj.2008.12.2522  0.786
2009 Zhang Z, Rosenhouse-Dantsker A, Adney SK, Logothetis DE. Regulation Of The Slo2.2 Channel By Na+ Ions And Phosphatidylinositol 4,5 Bisphosphate Biophysical Journal. 96: 482a. DOI: 10.1016/J.Bpj.2008.12.2484  0.596
2009 Baki L, Rodriguez AA, Rusinova R, Anderson CD, Logothetis DE. Hl-1 Cardiomyocytes As A Tool For The Study Of Regulation Of Kir3.1/Kir3.4 Channel Activity Biophysical Journal. 96: 465a. DOI: 10.1016/J.Bpj.2008.12.2393  0.796
2009 Nikolov EN, Logothetis DE, Ivanova-Nikolova TT. Rhythmic Control Of Atrial GIRK Channel Function By PKC Biophysical Journal. 96: 463a. DOI: 10.1016/J.Bpj.2008.12.2386  0.603
2008 Bernier LP, Ase AR, Chevallier S, Blais D, Zhao Q, Boué-Grabot E, Logothetis D, Séguéla P. Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12938-45. PMID 19036987 DOI: 10.1523/Jneurosci.3038-08.2008  0.483
2008 Rosenhouse-Dantsker A, Sui JL, Zhao Q, Rusinova R, Rodríguez-Menchaca AA, Zhang Z, Logothetis DE. A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2). Nature Chemical Biology. 4: 624-31. PMID 18794864 DOI: 10.1038/Nchembio.112  0.787
2008 Jin T, Sui JL, Rosenhouse-Dantsker A, Chan KW, Jan LY, Logothetis DE. Stoichiometry of Kir channels with phosphatidylinositol bisphosphate. Channels (Austin, Tex.). 2: 19-33. PMID 18690051 DOI: 10.4161/Chan.2.1.5942  0.762
2008 Bernier LP, Ase AR, Tong X, Hamel E, Blais D, Zhao Q, Logothetis DE, Séguéla P. Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate. Molecular Pharmacology. 74: 785-92. PMID 18523136 DOI: 10.1124/Mol.108.047019  0.494
2007 Zhao Q, Yang M, Ting AT, Logothetis DE. PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death. Channels (Austin, Tex.). 1: 46-55. PMID 19151591 DOI: 10.4161/Chan.3914  0.517
2007 Rosenhouse-Dantsker A, Logothetis DE. Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix. Channels (Austin, Tex.). 1: 189-97. PMID 18690025 DOI: 10.4161/Chan.4475  0.607
2007 Lopes CM, Remon JI, Matavel A, Sui JL, Keselman I, Medei E, Shen Y, Rosenhouse-Dantsker A, Rohacs T, Logothetis DE. Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels. Channels (Austin, Tex.). 1: 124-34. PMID 18690021 DOI: 10.4161/Chan.4322  0.84
2007 Keselman I, Fribourg M, Felsenfeld DP, Logothetis DE. Mechanism of PLC-mediated Kir3 current inhibition. Channels (Austin, Tex.). 1: 113-23. PMID 18690019 DOI: 10.4161/Chan.4321  0.847
2007 Rusinova R, Mirshahi T, Logothetis DE. Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits. The Journal of Biological Chemistry. 282: 34019-30. PMID 17872944 DOI: 10.1074/Jbc.M704928200  0.782
2007 Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B. An inactivation gate in the selectivity filter of KCNQ1 potassium channels. Biophysical Journal. 93: 4159-72. PMID 17704175 DOI: 10.1529/Biophysj.107.107987  0.418
2007 Logothetis DE, Nilius B. Dynamic changes in phosphoinositide levels control ion channel activity. PflüGers Archiv : European Journal of Physiology. 455: 1-3. PMID 17641911 DOI: 10.1007/S00424-007-0311-6  0.46
2007 Rosenhouse-Dantsker A, Logothetis DE. Molecular characteristics of phosphoinositide binding. PflüGers Archiv : European Journal of Physiology. 455: 45-53. PMID 17588168 DOI: 10.1007/S00424-007-0291-6  0.494
2007 Logothetis DE, Jin T, Lupyan D, Rosenhouse-Dantsker A. Phosphoinositide-mediated gating of inwardly rectifying K(+) channels. PflüGers Archiv : European Journal of Physiology. 455: 83-95. PMID 17520276 DOI: 10.1007/S00424-007-0276-5  0.758
2007 Michailidis IE, Helton TD, Petrou VI, Mirshahi T, Ehlers MD, Logothetis DE. Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5523-32. PMID 17507574 DOI: 10.1523/Jneurosci.4378-06.2007  0.803
2007 Logothetis DE, Lupyan D, Rosenhouse-Dantsker A. Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding. The Journal of Physiology. 582: 953-65. PMID 17495041 DOI: 10.1113/Jphysiol.2007.133157  0.58
2007 Zhao Q, Logothetis DE, Séguéla P. Regulation of ATP-gated P2X receptors by phosphoinositides. PflüGers Archiv : European Journal of Physiology. 455: 181-5. PMID 17479282 DOI: 10.1007/S00424-007-0271-X  0.463
2006 Ishii Y, Pirkmaier A, Alvarez JV, Frank DA, Keselman I, Logothetis D, Mandeli J, O'Connell MJ, Waxman S, Germain D. Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. Journal of the National Cancer Institute. 98: 1238-47. PMID 16954476 DOI: 10.1093/Jnci/Djj334  0.73
2006 Rosenhouse-Dantsker A, Logothetis DE. New roles for a key glycine and its neighboring residue in potassium channel gating. Biophysical Journal. 91: 2860-73. PMID 16877518 DOI: 10.1529/Biophysj.105.080242  0.594
2006 Mirshahi T, Logothetis DE, Rosenhouse-Dantsker A. Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation. Biophysical Journal. 90: 2776-85. PMID 16428273 DOI: 10.1529/Biophysj.105.069302  0.517
2005 Rohács T, Lopes CM, Michailidis I, Logothetis DE. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nature Neuroscience. 8: 626-34. PMID 15852009 DOI: 10.1038/Nn1451  0.808
2005 Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE. PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. The Journal of Physiology. 564: 117-29. PMID 15677683 DOI: 10.1113/Jphysiol.2004.081935  0.594
2004 Scott DB, Michailidis I, Mu Y, Logothetis D, Ehlers MD. Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7096-109. PMID 15306643 DOI: 10.1523/Jneurosci.0780-04.2004  0.744
2004 Du X, Zhang H, Lopes C, Mirshahi T, Rohacs T, Logothetis DE. Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. The Journal of Biological Chemistry. 279: 37271-81. PMID 15155739 DOI: 10.1074/Jbc.M403413200  0.617
2004 Mirshahi T, Logothetis DE. Molecular determinants responsible for differential cellular distribution of G protein-gated inwardly rectifying K+ channels. The Journal of Biological Chemistry. 279: 11890-7. PMID 14703518 DOI: 10.1074/Jbc.M313322200  0.559
2003 Peng L, Mirshahi T, Zhang H, Hirsch JP, Logothetis DE. Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity. The Journal of Biological Chemistry. 278: 50203-11. PMID 12975366 DOI: 10.1074/Jbc.M308299200  0.557
2003 Mirshahi T, Jin T, Logothetis DE. G beta gamma and KACh: old story, new insights. Science's Stke : Signal Transduction Knowledge Environment. 2003: PE32. PMID 12902568 DOI: 10.1126/Stke.2003.194.Pe32  0.758
2003 Chan KW, Zhang H, Logothetis DE. N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. The Embo Journal. 22: 3833-43. PMID 12881418 DOI: 10.1093/Emboj/Cdg376  0.542
2003 Davila V, Yan Z, Craciun LC, Logothetis D, Sulzer D. D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5693-7. PMID 12843272  0.661
2003 Zhang H, Craciun LC, Mirshahi T, Rohács T, Lopes CM, Jin T, Logothetis DE. PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron. 37: 963-75. PMID 12670425 DOI: 10.1016/S0896-6273(03)00125-9  0.835
2003 Rohács T, Lopes CM, Jin T, Ramdya PP, Molnár Z, Logothetis DE. Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proceedings of the National Academy of Sciences of the United States of America. 100: 745-50. PMID 12525701 DOI: 10.1073/Pnas.0236364100  0.756
2002 Mirshahi T, Logothetis DE. GIRK channel trafficking: different paths for different family members. Molecular Interventions. 2: 289-91. PMID 14993383 DOI: 10.1124/Mi.2.5.289  0.45
2002 Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE. The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment. Molecular Cell. 10: 469-81. PMID 12408817 DOI: 10.1016/S1097-2765(02)00659-7  0.729
2002 Mirshahi T, Mittal V, Zhang H, Linder ME, Logothetis DE. Distinct sites on G protein beta gamma subunits regulate different effector functions. The Journal of Biological Chemistry. 277: 36345-50. PMID 12124391 DOI: 10.1074/Jbc.M205359200  0.403
2002 Lopes CM, Zhang H, Rohacs T, Jin T, Yang J, Logothetis DE. Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron. 34: 933-44. PMID 12086641 DOI: 10.1016/S0896-6273(02)00725-0  0.747
2002 He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE. Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. The Journal of Biological Chemistry. 277: 6088-96. PMID 11741896 DOI: 10.1074/Jbc.M104851200  0.679
2002 Mirshahi T, Robillard L, Zhang H, Hébert TE, Logothetis DE. Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels. The Journal of Biological Chemistry. 277: 7348-55. PMID 11707461 DOI: 10.1074/Jbc.M109999200  0.606
2002 Rohács T, Lopes C, Mirshahi T, Jin T, Zhang H, Logothetis DE. Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods in Enzymology. 345: 71-92. PMID 11665643 DOI: 10.1016/S0076-6879(02)45008-2  0.737
2001 Zhu L, Wu X, Wu MB, Chan KW, Logothetis DE, Thornhill WB. Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain. Journal of Molecular Neuroscience : Mn. 16: 21-32. PMID 11345517 DOI: 10.1385/Jmn:16:1:21  0.386
2000 Kobrinsky E, Mirshahi T, Zhang H, Jin T, Logothetis DE. Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization. Nature Cell Biology. 2: 507-14. PMID 10934471 DOI: 10.1038/35019544  0.761
2000 Pabon A, Chan KW, Sui JL, Wu X, Logothetis DE, Thornhill WB. Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. The Journal of Biological Chemistry. 275: 30677-82. PMID 10889209 DOI: 10.1074/Jbc.M005338200  0.518
1999 Rohács T, Chen J, Prestwich GD, Logothetis DE. Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. The Journal of Biological Chemistry. 274: 36065-72. PMID 10593888 DOI: 10.1074/Jbc.274.51.36065  0.537
1999 Zhang H, He C, Yan X, Mirshahi T, Logothetis DE. Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology. 1: 183-8. PMID 10559906 DOI: 10.1038/11103  0.59
1999 Logothetis DE, Zhang H. Gating of G protein-sensitive inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate. The Journal of Physiology. 520: 630. PMID 10545130 DOI: 10.1111/J.1469-7793.1999.00630.X  0.58
1999 Petit-Jacques J, Sui JL, Logothetis DE. Synergistic activation of G protein-gated inwardly rectifying potassium channels by the betagamma subunits of G proteins and Na(+) and Mg(2+) ions. The Journal of General Physiology. 114: 673-84. PMID 10532964 DOI: 10.1085/Jgp.114.5.673  0.559
1999 Sui JL, Chan K, Langan MN, Vivaudou M, Logothetis DE. G protein gated potassium channels. Advances in Second Messenger and Phosphoprotein Research. 33: 179-201. PMID 10218119  0.452
1999 He C, Zhang H, Mirshahi T, Logothetis DE. Identification of a potassium channel site that interacts with G protein betagamma subunits to mediate agonist-induced signaling. The Journal of Biological Chemistry. 274: 12517-24. PMID 10212228 DOI: 10.1074/Jbc.274.18.12517  0.587
1999 Sui JL, Petit-Jacques J, Logothetis DE. Chapter 18 Effect of Phosphatidylinositol Phosphates on the Gating of G-Protein-Activated K+Channels Current Topics in Membranes and Transport. 46: 337-354. DOI: 10.1016/S0070-2161(08)60934-X  0.546
1998 Kozak JA, Misler S, Logothetis DE. Characterization of a Ca2+-activated K+ current in insulin-secreting murine betaTC-3 cells. The Journal of Physiology. 509: 355-70. PMID 9575286 DOI: 10.1111/J.1469-7793.1998.355Bn.X  0.566
1998 Sui JL, Petit-Jacques J, Logothetis DE. Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates. Proceedings of the National Academy of Sciences of the United States of America. 95: 1307-12. PMID 9448327 DOI: 10.1073/Pnas.95.3.1307  0.597
1998 Kozak JA, Misler S, Logothetis DE. Characterization of a Ca2+-activated K+ current in insulin-secreting murine βTC-3 cells Journal of Physiology. 509: 355-370. DOI: 10.1111/j.1469-7793.1998.355bn.x  0.395
1997 Vivaudou M, Chan KW, Sui JL, Jan LY, Reuveny E, Logothetis DE. Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. The Journal of Biological Chemistry. 272: 31553-60. PMID 9395492 DOI: 10.1074/Jbc.272.50.31553  0.562
1997 Kozak JA, Logothetis DE. A calcium-dependent chloride current in insulin-secreting beta TC-3 cells. Pflã¼Gers Archiv : European Journal of Physiology. 433: 679-90. PMID 9049157 DOI: 10.1007/S004240050332  0.514
1997 Chan KW, Sui JL, Vivaudou M, Logothetis DE. Specific regions of heteromeric subunits involved in enhancement of G protein-gated K+ channel activity. The Journal of Biological Chemistry. 272: 6548-55. PMID 9045681 DOI: 10.1074/Jbc.272.10.6548  0.583
1996 Chan KW, Sui JL, Vivaudou M, Logothetis DE. Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit. Proceedings of the National Academy of Sciences of the United States of America. 93: 14193-8. PMID 8943083 DOI: 10.1073/Pnas.93.24.14193  0.595
1996 Sui JL, Chan KW, Logothetis DE. Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism. The Journal of General Physiology. 108: 381-91. PMID 8923264 DOI: 10.1085/Jgp.108.5.381  0.564
1996 Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE. A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. The Journal of General Physiology. 107: 381-97. PMID 8868049 DOI: 10.1085/jgp.107.3.381  0.64
1996 Langan MS, Chan KW, Sui J, Logothetis DE. G-protein coupling of a novel recombinant potassium channel Journal of the American College of Cardiology. 27: 96. DOI: 10.1016/S0735-1097(96)80592-4  0.508
1994 Castle NA, Fadous S, Logothetis DE, Wang GK. Aminopyridine block of Kv1.1 potassium channels expressed in mammalian cells and Xenopus oocytes. Molecular Pharmacology. 45: 1242-52. PMID 8022416  0.378
1994 Castle NA, Fadous SR, Logothetis DE, Wang GK. 4-Aminopyridine binding and slow inactivation are mutually exclusive in rat Kv1.1 and Shaker potassium channels. Molecular Pharmacology. 46: 1175-81. PMID 7808439  0.408
1993 Logothetis DE, Kammen BF, Lindpaintner K, Bisbas D, Nadal-Ginard B. Gating charge differences between two voltage-gated K+ channels are due to the specific charge content of their respective S4 regions. Neuron. 10: 1121-9. PMID 8318233 DOI: 10.1016/0896-6273(93)90060-5  0.484
1992 Logothetis DE, Movahedi S, Satler C, Lindpaintner K, Nadal-Ginard B. Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge. Neuron. 8: 531-40. PMID 1550676 DOI: 10.1016/0896-6273(92)90281-H  0.485
1990 Koren G, Liman ER, Logothetis DE, Nadal-Ginard B, Hess P. Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron. 4: 39-51. PMID 2310574 DOI: 10.1016/0896-6273(90)90442-I  0.51
1989 Plummer MR, Logothetis DE, Hess P. Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron. 2: 1453-63. PMID 2560643 DOI: 10.1016/0896-6273(89)90191-8  0.46
1988 Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. The American Journal of Physiology. 254: H192-7. PMID 2827524 DOI: 10.1152/Ajpheart.1988.254.1.H192  0.593
1988 Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 85: 5814-8. PMID 2457901 DOI: 10.1073/Pnas.85.16.5814  0.574
1987 Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 325: 321-6. PMID 2433589 DOI: 10.1038/325321A0  0.658
1987 Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. G protein opening of K+ channels Nature. 327: 22. DOI: 10.1038/327022A0  0.593
1987 Kurachi Y, Nakajima T, Sugimoto T, Clapham DE, Logothetis DE, Neer EJ, Galper J. On the molecular regulation of muscarinic K+ channel by GTP-binding proteins in cardiac atrial myocytes Biomedical Research. 8: 135-142.  0.562
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