David E. Clapham - Publications

Affiliations: 
Neurobiology Harvard Medical School/HHMI, Boston, MA, United States 
Area:
Ion channels and calcium signaling
Website:
http://www.fas.harvard.edu/~biophys/David_E_Clapham.htm

239 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, ... ... Clapham DE, et al. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Science Advances. 5: eaaw7935. PMID 31355338 DOI: 10.1126/sciadv.aaw7935  0.68
2018 Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. PMID 30108148 DOI: 10.1073/pnas.1810719115  0.68
2018 Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J. Structure of the mouse TRPC4 ion channel. Nature Communications. 9: 3102. PMID 30082700 DOI: 10.1038/s41467-018-05247-9  0.68
2018 Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Cryo-EM structure of the polycystin 2-l1 ion channel. Elife. 7. PMID 30004384 DOI: 10.7554/eLife.36931  0.52
2018 Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full-length human TRPM4. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463718 DOI: 10.1073/pnas.1722038115  0.68
2018 Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 7. PMID 29443690 DOI: 10.7554/eLife.33183  0.52
2017 Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784805 DOI: 10.1073/pnas.1708427114  0.56
2017 Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America. PMID 28696294 DOI: 10.1073/pnas.1707380114  0.56
2017 Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Elife. 6. PMID 28226241 DOI: 10.7554/eLife.23082  0.72
2016 Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. The Journal of General Physiology. PMID 27999145 DOI: 10.1085/jgp.201611696  0.44
2016 Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 167: 763-773.e11. PMID 27768895 DOI: 10.1016/j.cell.2016.09.048  0.44
2016 DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 5. PMID 27348301 DOI: 10.7554/eLife.13413  0.44
2016 Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976564 DOI: 10.1073/pnas.1602264113  0.44
2016 Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. The Embo Journal. PMID 26873592 DOI: 10.15252/embj.201593285  0.44
2016 Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chemical Senses. PMID 26843529 DOI: 10.1093/chemse/bjv071  1
2015 Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. Acs Chemical Biology. PMID 26674547 DOI: 10.1021/acschembio.5b00748  0.36
2015 Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 4. PMID 26650848 DOI: 10.7554/eLife.11066  1
2015 Clapham DE. Structural biology: Pain-sensing TRPA1 channel resolved. Nature. 520: 439-41. PMID 25855290 DOI: 10.1038/nature14383  1
2015 Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 57: 166-73. PMID 25498309 DOI: 10.1016/j.ceca.2014.11.007  0.36
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 3. PMID 25385530 DOI: 10.7554/eLife.04387  1
2014 Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Molecular Biology and Evolution. 31: 2735-40. PMID 25063443 DOI: 10.1093/molbev/msu218  1
2014 Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 157: 1061-72. PMID 24855944 DOI: 10.1016/j.cell.2014.03.046  1
2014 Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proceedings of the National Academy of Sciences of the United States of America. 111: 8428-33. PMID 24850863 DOI: 10.1073/pnas.1406855111  1
2014 Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 157: 808-22. PMID 24813608 DOI: 10.1016/j.cell.2014.02.056  1
2014 Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochemical and Biophysical Research Communications. 449: 367-9. PMID 24792175 DOI: 10.1016/j.bbrc.2014.04.141  1
2014 Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Reports. 6: 1122-8. PMID 24630989 DOI: 10.1016/j.celrep.2014.02.015  1
2014 Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. Jama Neurology. 71: 640-5. PMID 24615367 DOI: 10.1001/jamaneurol.2014.21  1
2014 Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3653-67. PMID 24599464 DOI: 10.1523/JNEUROSCI.2274-13.2014  1
2014 Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. The Journal of General Physiology. 143: 67-73. PMID 24344246 DOI: 10.1085/jgp.201311096  1
2014 DeCaen PG, Delling M, Vien TN, Clapham DE. Corrigendum: Direct recording and molecular identification of the calcium channel of primary cilia Nature. 513: 266. DOI: 10.1038/nature13631  1
2013 DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 504: 315-8. PMID 24336289 DOI: 10.1038/nature12832  1
2013 Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 504: 311-4. PMID 24336288 DOI: 10.1038/nature12833  1
2013 Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Reports. 5: 1375-86. PMID 24316078 DOI: 10.1016/j.celrep.2013.11.007  1
2013 Clapham DE. The mother of all endocytosis. Elife. 2: e01738. PMID 24282238 DOI: 10.7554/eLife.01738  1
2013 Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (New York, N.Y.). 342: 1379-82. PMID 24231807 DOI: 10.1126/science.1242993  1
2013 Clapham DE. Sperm BerserKers. Elife. 2: e01469. PMID 24137547 DOI: 10.7554/eLife.01469  1
2013 Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nature Communications. 4: 2465. PMID 24051986 DOI: 10.1038/ncomms3465  1
2013 Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. The Journal of General Physiology. 142: 305-13. PMID 23980198 DOI: 10.1085/jgp.201311011  1
2013 Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proceedings of the National Academy of Sciences of the United States of America. 110: E3037-46. PMID 23878236 DOI: 10.1073/pnas.1311865110  1
2013 Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. The Journal of General Physiology. 142: 113-26. PMID 23858001 DOI: 10.1085/jgp.201310996  1
2013 Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2: e00704. PMID 23755363 DOI: 10.7554/eLife.00704  1
2013 Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 128: 101-14. PMID 23734001 DOI: 10.1161/CIRCULATIONAHA.112.000768  1
2013 Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proceedings of the National Academy of Sciences of the United States of America. 110: E2249-54. PMID 23716663 DOI: 10.1073/pnas.1308558110  1
2013 Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 6364-9. PMID 23542377 DOI: 10.1073/pnas.1214667110  1
2013 Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods in Enzymology. 525: 59-83. PMID 23522465 DOI: 10.1016/B978-0-12-397944-5.00004-3  1
2013 Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Current Biology : Cb. 23: 443-52. PMID 23453951 DOI: 10.1016/j.cub.2013.02.007  1
2013 Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 152: 778-90. PMID 23394946 DOI: 10.1016/j.cell.2013.01.023  1
2013 Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Research. 23: 409-22. PMID 23247626 DOI: 10.1038/cr.2012.173  1
2012 Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151: 372-83. PMID 23063126 DOI: 10.1016/j.cell.2012.08.036  1
2012 Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. Plos One. 7: e46865. PMID 23056495 DOI: 10.1371/journal.pone.0046865  1
2012 Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, ... ... Clapham DE, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151: 96-110. PMID 23021218 DOI: 10.1016/j.cell.2012.08.034  1
2012 Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nature Communications. 3: 990. PMID 22871809 DOI: 10.1038/ncomms1999  1
2012 Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Developmental Cell. 22: 1149-62. PMID 22698280 DOI: 10.1016/j.devcel.2012.04.006  1
2012 Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 486: 130-4. PMID 22678295 DOI: 10.1038/nature11054  1
2012 Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proceedings of the National Academy of Sciences of the United States of America. 109: 7888-92. PMID 22547824 DOI: 10.1073/pnas.1205869109  1
2012 Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience. 15: 565-73. PMID 22388960 DOI: 10.1038/nn.3059  1
2012 Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 109: E225-33. PMID 22203997 DOI: 10.1073/pnas.1120033109  1
2012 Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annual Review of Physiology. 74: 453-75. PMID 22017176 DOI: 10.1146/annurev-physiol-020911-153258  1
2012 Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Molecular Biology and Evolution. 29: 91-100. PMID 21680871 DOI: 10.1093/molbev/msr149  1
2011 Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proceedings of the National Academy of Sciences of the United States of America. 108: 19492-7. PMID 22109551 DOI: 10.1073/pnas.1117485108  1
2011 Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proceedings of the National Academy of Sciences of the United States of America. 108: 19234-9. PMID 22084111 DOI: 10.1073/pnas.1117231108  1
2011 Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, et al. Melanopsin signalling in mammalian iris and retina. Nature. 479: 67-73. PMID 22051675 DOI: 10.1038/nature10567  1
2011 Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proceedings of the National Academy of Sciences of the United States of America. 108: 18114-9. PMID 22025699 DOI: 10.1073/pnas.1115387108  1
2011 Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 108: 14342-7. PMID 21831833 DOI: 10.1073/pnas.1111695108  1
2011 Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Advances in Experimental Medicine and Biology. 704: 173-83. PMID 21290295 DOI: 10.1007/978-94-007-0265-3_9  1
2011 Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nature Communications. 2: 153. PMID 21224844 DOI: 10.1038/ncomms1153  1
2011 Clapham D. Feeling the heat - Temperature sensing by ion channels - How do they do it? Biochemist. 33: 22-25.  1
2010 Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacological Reviews. 62: 381-404. PMID 20716668 DOI: 10.1124/pr.110.002725  1
2010 Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MS, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nature Structural & Molecular Biology. 17: 869-75. PMID 20543828 DOI: 10.1038/nsmb.1826  1
2010 Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Letters. 10: 2211-9. PMID 20446663 DOI: 10.1021/nl101157z  1
2010 Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, ... Clapham DE, et al. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 141: 331-43. PMID 20403327 DOI: 10.1016/j.cell.2010.03.013  1
2010 Clapham DE. Transient receptor potential (TRP) channels Encyclopedia of Neuroscience. 1109-1133. DOI: 10.1016/B978-008045046-9.01634-X  1
2009 Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (New York, N.Y.). 326: 144-7. PMID 19797662 DOI: 10.1126/science.1175145  1
2009 Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 106: 15750-5. PMID 19717468 DOI: 10.1073/pnas.0908332106  1
2009 Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 137: 761-72. PMID 19450521 DOI: 10.1016/j.cell.2009.03.039  1
2009 Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Science Signaling. 2: ra21. PMID 19436059 DOI: 10.1126/scisignal.2000146  1
2009 Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. The Journal of General Physiology. 133: 525-46. PMID 19398778 DOI: 10.1085/jgp.200810153  1
2009 Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proceedings of the National Academy of Sciences of the United States of America. 106: 7642-7. PMID 19372380 DOI: 10.1073/pnas.0902761106  1
2009 Clapham DE. A STIMulus Package puts orai calcium channels to work. Cell. 136: 814-6. PMID 19269360 DOI: 10.1016/j.cell.2009.02.022  1
2009 Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nature Protocols. 4: 174-96. PMID 19180088 DOI: 10.1038/nprot.2008.223  1
2008 Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. Plos One. 3: e3569. PMID 18974790 DOI: 10.1371/journal.pone.0003569  1
2008 Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (New York, N.Y.). 322: 756-60. PMID 18974357 DOI: 10.1126/science.1163493  1
2008 Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. The International Journal of Developmental Biology. 52: 607-13. PMID 18649274 DOI: 10.1387/ijdb.072554bn  1
2008 Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America. 105: 8304-8. PMID 18539771 DOI: 10.1073/pnas.0800881105  1
2008 Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. Plos One. 3: e2082. PMID 18461159 DOI: 10.1371/journal.pone.0002082  1
2008 Rama S, Krapivinsky G, Clapham DE, Medina I. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Molecular and Cellular Neurosciences. 38: 183-8. PMID 18417361 DOI: 10.1016/j.mcn.2008.02.007  1
2008 Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. The Journal of Physiology. 586: 2477-86. PMID 18356202 DOI: 10.1113/jphysiol.2007.149427  1
2007 Clapham DE. Calcium signaling. Cell. 131: 1047-58. PMID 18083096 DOI: 10.1016/j.cell.2007.11.028  1
2007 Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology (Reading, England). 153: 4027-38. PMID 18048917 DOI: 10.1099/mic.0.2007/012070-0  1
2007 Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 18321-6. PMID 17989217 DOI: 10.1073/pnas.0709096104  1
2007 Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. The Journal of Biological Chemistry. 282: 18945-52. PMID 17478420 DOI: 10.1074/jbc.M701083200  1
2007 Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proceedings of the National Academy of Sciences of the United States of America. 104: 7688-92. PMID 17460039 DOI: 10.1073/pnas.0702018104  1
2007 Clapham DE. SnapShot: mammalian TRP channels. Cell. 129: 220. PMID 17418797 DOI: 10.1016/j.cell.2007.03.034  1
2007 Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America. 104: 1219-23. PMID 17227845 DOI: 10.1073/pnas.0610286104  1
2006 Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 127: 1137-50. PMID 17123591 DOI: 10.1016/j.cell.2006.10.028  1
2006 Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky SM, Clapham DE. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron. 52: 485-96. PMID 17088214 DOI: 10.1016/j.neuron.2006.09.033  1
2006 Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. The Journal of Biological Chemistry. 281: 29897-904. PMID 16899456 DOI: 10.1074/jbc.M605394200  1
2006 Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. The Embo Journal. 25: 2978-88. PMID 16763551 DOI: 10.1038/sj.emboj.7601186  1
2006 Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. The Journal of Biological Chemistry. 281: 22085-91. PMID 16754686 DOI: 10.1074/jbc.M603316200  1
2006 Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nature Neuroscience. 9: 628-35. PMID 16617338 DOI: 10.1038/nn1692  1
2006 Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 440: 1213-6. PMID 16554753 DOI: 10.1038/nature04700  1
2006 Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 439: 737-40. PMID 16467839 DOI: 10.1038/nature04417  1
2006 Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annual Review of Physiology. 68: 619-47. PMID 16460286 DOI: 10.1146/annurev.physiol.68.040204.100431  1
2006 Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circulation Research. 98: 245-53. PMID 16357306 DOI: 10.1161/01.RES.0000200179.29375.cc  1
2005 Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacological Reviews. 57: 509-26. PMID 16382105 DOI: 10.1124/pr.57.4.11  1
2005 Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. Pharmacological Reviews. 57: 451-4. PMID 16382101 DOI: 10.1124/pr.57.4.7  1
2005 Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacological Reviews. 57: 427-50. PMID 16382100 DOI: 10.1124/pr.57.4.6  1
2005 Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8924-37. PMID 16192383 DOI: 10.1523/JNEUROSCI.2574-05.2005  1
2005 Desai BN, Clapham DE. TRP channels and mice deficient in TRP channels. PflüGers Archiv : European Journal of Physiology. 451: 11-8. PMID 16078044 DOI: 10.1007/s00424-005-1429-z  1
2005 Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, ... ... Clapham DE, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nature Genetics. 37: 739-44. PMID 15924139 DOI: 10.1038/ng1592  1
2005 Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Molecular and Cellular Biology. 25: 2632-43. PMID 15767669 DOI: 10.1128/MCB.25.7.2632-2643.2005  1
2004 Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8300-9. PMID 15385613 DOI: 10.1523/JNEUROSCI.2893-04.2004  1
2004 Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 43: 563-74. PMID 15312654 DOI: 10.1016/j.neuron.2004.08.003  1
2004 Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nature Cell Biology. 6: 709-20. PMID 15258588 DOI: 10.1038/ncb1150  1
2004 Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences of the United States of America. 101: 10566-71. PMID 15243157 DOI: 10.1073/pnas.0402692101  1
2004 Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Current Opinion in Neurobiology. 14: 362-9. PMID 15194117 DOI: 10.1016/j.conb.2004.05.003  1
2004 Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. Plos Biology. 2: E50. PMID 15024413 DOI: 10.1371/journal.pbio.0020050  1
2004 Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 427: 360-4. PMID 14737170 DOI: 10.1038/nature02246  1
2004 Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. The Journal of Biological Chemistry. 279: 9532-8. PMID 14665618 DOI: 10.1074/jbc.M313100200  1
2004 Bezzerides VJ, Clapham DE. Near membrane protein dynamics revealed by evanescent field microscopy Proceedings of Spie - the International Society For Optical Engineering. 5467: 326-337. DOI: 10.1117/12.548399  1
2004 Ackerman MJ, Clapham DE. Excitability and Conduction Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 311-335. DOI: 10.1016/B978-0-7216-9428-3.50023-8  1
2004 Khositseth A, Clapham DE, Ackerman MJ. Intracellular Signaling and Regulation of Cardiac Ion Channels Cardiac Electrophysiology: Fourth Edition. 33-41. DOI: 10.1016/B0-7216-0323-8/50007-5  1
2003 Clapham DE. Symmetry, selectivity, and the 2003 Nobel Prize. Cell. 115: 641-6. PMID 14675526 DOI: 10.1016/S0092-8674(03)00980-2  1
2003 Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacological Reviews. 55: 591-6. PMID 14657417 DOI: 10.1124/pr.55.4.6  1
2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/pr.55.4.9  1
2003 Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proceedings of the National Academy of Sciences of the United States of America. 100: 14864-8. PMID 14657352 DOI: 10.1073/pnas.2536658100  1
2003 Clapham DE. TRP channels as cellular sensors. Nature. 426: 517-24. PMID 14654832 DOI: 10.1038/nature02196  1
2003 Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 40: 775-84. PMID 14622581 DOI: 10.1016/S0896-6273(03)00645-7  1
2003 Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nature Neuroscience. 6: 837-45. PMID 12858178 DOI: 10.1038/nn1092  1
2003 Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. The Journal of Biological Chemistry. 278: 39014-9. PMID 12857742 DOI: 10.1074/jbc.M306705200  1
2003 Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Developmental Cell. 4: 561-74. PMID 12689594 DOI: 10.1016/S1534-5807(03)00087-X  1
2003 Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophysical Journal. 84: 1317-27. PMID 12547812 DOI: 10.1016/S0006-3495(03)74947-9  1
2003 Catterall WA, Chandy KG, Clapham DE, Gutman GA, Hofmann F, Harmar AJ, Abernethy DR, Spedding M. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels Pharmacological Reviews. 55: 573-574. DOI: 10.1124/pr.55.4.5  1
2002 Sandler VM, Wang S, Angelo K, Lo HG, Breakefield XO, Clapham DE. Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. Journal of Neuroscience Methods. 121: 211-9. PMID 12468010 DOI: 10.1016/S0165-0270(02)00262-5  1
2002 Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. The Journal of General Physiology. 120: 845-53. PMID 12451053 DOI: 10.1085/jgp.20028699  1
2002 Clapham DE. Sorting out MIC, TRP, and CRAC ion channels. The Journal of General Physiology. 120: 217-20. PMID 12149282 DOI: 10.1085/jgp.20028618  1
2002 Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 418: 181-6. PMID 12077604 DOI: 10.1038/nature00882  1
2002 Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nature Cell Biology. 4: 329-36. PMID 11941371 DOI: 10.1038/ncb781  1
2002 Clapham DE. Signal transduction. Hot and cold TRP ion channels. Science (New York, N.Y.). 295: 2228-9. PMID 11910099 DOI: 10.1126/science.1070766  1
2002 Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene. 284: 241-50. PMID 11891065 DOI: 10.1016/S0378-1119(01)00884-8  1
2002 Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, et al. A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell. 9: 229-31. PMID 11864597 DOI: 10.1016/S1097-2765(02)00448-3  1
2001 Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science (New York, N.Y.). 294: 2372-5. PMID 11743207 DOI: 10.1126/science.1065635  1
2001 Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 98: 12527-31. PMID 11675491 DOI: 10.1073/pnas.221454998  1
2001 Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 413: 603-9. PMID 11595941 DOI: 10.1038/35098027  1
2001 Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. Journal of the American College of Cardiology. 37: 2136-43. PMID 11419900 DOI: 10.1016/S0735-1097(01)01304-3  1
2001 Clapham DE, Runnels LW, Strübing C. The TRP ion channel family. Nature Reviews. Neuroscience. 2: 387-96. PMID 11389472 DOI: 10.1038/35077544  1
2001 Hsu Sf, O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. Journal of Immunology (Baltimore, Md. : 1950). 166: 6126-33. PMID 11342632  1
2001 Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 29: 645-55. PMID 11301024 DOI: 10.1016/S0896-6273(01)00240-9  1
2001 Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 410: 705-9. PMID 11287959 DOI: 10.1038/35070596  1
2001 Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (New York, N.Y.). 291: 1043-7. PMID 11161216 DOI: 10.1126/science.1058519  1
2001 Corey S, Clapham DE. The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). The Journal of Biological Chemistry. 276: 11409-13. PMID 11148218 DOI: 10.1074/jbc.M100058200  1
2000 Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. The Journal of Biological Chemistry. 275: 36211-6. PMID 10956667 DOI: 10.1074/jbc.M007087200  1
2000 Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5608-15. PMID 10908597  1
2000 Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). The Journal of Biological Chemistry. 275: 29709-16. PMID 10900209 DOI: 10.1074/jbc.M004989200  1
2000 Franco-Obregón A, Wang HW, Clapham DE. Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophysical Journal. 79: 202-14. PMID 10866948 DOI: 10.1016/S0006-3495(00)76284-9  1
2000 Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. The Journal of Biological Chemistry. 275: 12363-6. PMID 10777517 DOI: 10.1074/jbc.275.17.12363  1
1999 Clapham DE. More pieces of the K+ ion channel puzzle. Nature Structural Biology. 6: 807-10. PMID 10467088 DOI: 10.1038/12261  1
1999 Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Annals of the New York Academy of Sciences. 868: 386-98. PMID 10414308 DOI: 10.1111/j.1749-6632.1999.tb11300.x  1
1999 Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron. 23: 149-57. PMID 10402201 DOI: 10.1016/S0896-6273(00)80761-8  1
1999 Wang H, Clapham DE. Conformational changes of the in situ nuclear pore complex. Biophysical Journal. 77: 241-7. PMID 10388753 DOI: 10.1016/S0006-3495(99)76885-2  1
1999 Clapham DE. Unlocking family secrets: K+ channel transmembrane domains. Cell. 97: 547-50. PMID 10367883 DOI: 10.1016/S0092-8674(00)80765-5  1
1999 Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. The Journal of Membrane Biology. 169: 123-9. PMID 10341034 DOI: 10.1007/s002329900524  1
1999 Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Molecular and Cellular Biology. 19: 4113-20. PMID 10330151  1
1999 Strübing C, Clapham DE. Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. The Journal of General Physiology. 113: 239-48. PMID 9925822 DOI: 10.1085/jgp.113.2.239  1
1999 Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. The Journal of Biological Chemistry. 274: 2571-82. PMID 9891030 DOI: 10.1074/jbc.274.4.2571  1
1999 Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophysical Journal. 76: 246-52. PMID 9876138 DOI: 10.1016/S0006-3495(99)77193-6  1
1999 Navarro B, Corey S, Kennedy M, Clapham DE. Chapter 16 G-Protein-Gated Potassium Channels: Implication for the weaver Mouse Current Topics in Membranes and Transport. 46: 295-320. DOI: 10.1016/S0070-2161(08)60932-6  1
1998 Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nature Neuroscience. 1: 114-8. PMID 10195125 DOI: 10.1038/363  1
1998 Franco-Obregón A, Clapham DE. Touch channels sense blood pressure. Neuron. 21: 1224-6. PMID 9883713  1
1998 Corey S, Clapham DE. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. The Journal of Biological Chemistry. 273: 27499-504. PMID 9765280 DOI: 10.1074/jbc.273.42.27499  1
1998 Clapham DE. Not so funny anymore: pacing channels are cloned. Neuron. 21: 5-7. PMID 9697846 DOI: 10.1016/S0896-6273(00)80508-5  1
1998 Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. The Journal of Biological Chemistry. 273: 16946-52. PMID 9642257 DOI: 10.1074/jbc.273.27.16946  1
1998 Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. Neuron. 20: 995-1005. PMID 9620703 DOI: 10.1016/S0896-6273(00)80480-8  1
1998 Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. Cell Calcium. 23: 91-101. PMID 9601604 DOI: 10.1016/S0143-4160(98)90107-5  1
1998 Clapham DE. At last, the structure of an ion-selective channel. Nature Structural Biology. 5: 342-4. PMID 9586991 DOI: 10.1038/nsb0598-342  1
1998 Clapham DE. The list of potential volume-sensitive chloride currents continues to swell (and shrink). The Journal of General Physiology. 111: 623-4. PMID 9565400 DOI: 10.1085/jgp.111.5.623  1
1998 Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. The Journal of Biological Chemistry. 273: 10811-4. PMID 9556550 DOI: 10.1074/jbc.273.18.10811  1
1998 Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Molecular and Cellular Biology. 18: 1652-9. PMID 9488482  1
1998 Corey S, Krapivinsky G, Krapivinsky L, Clapham DE. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. The Journal of Biological Chemistry. 273: 5271-8. PMID 9478984 DOI: 10.1074/jbc.273.9.5271  1
1998 Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 20: 103-14. PMID 9459446 DOI: 10.1016/S0896-6273(00)80438-9  1
1997 Clapham DE. The molecular control of cardiac ion channels. Heart and Vessels. 168-9. PMID 9476572  1
1997 Clapham DE. Some like it hot: spicing up ion channels. Nature. 389: 783-4. PMID 9349801 DOI: 10.1038/39724  1
1997 Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 19: 787-92. PMID 9297969 DOI: 10.1002/bies.950190908  1
1997 Ackerman MJ, Clapham DE. Ion channels--basic science and clinical disease. The New England Journal of Medicine. 336: 1575-86. PMID 9164815 DOI: 10.1056/NEJM199705293362207  1
1997 Perez-Terzic C, Stehno-Bittel L, Clapham DE. Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. Cell Calcium. 21: 275-82. PMID 9160163  1
1997 Clapham DE, Neer EJ. G protein beta gamma subunits. Annual Review of Pharmacology and Toxicology. 37: 167-203. PMID 9131251 DOI: 10.1146/annurev.pharmtox.37.1.167  1
1997 Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 40: 402-8. PMID 9073507 DOI: 10.1006/geno.1996.4600  1
1997 Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics. 40: 395-401. PMID 9073506 DOI: 10.1006/geno.1997.4599  1
1996 Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology. 35: 831-9. PMID 8938714 DOI: 10.1016/0028-3908(96)00132-3  1
1996 Clapham DE. Intracellular signalling: more jobs for G beta gamma. Current Biology : Cb. 6: 814-6. PMID 8835861 DOI: 10.1016/S0960-9822(02)00602-4  1
1996 Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Nuclear ion channels and regulation of the nuclear pore. Society of General Physiologists Series. 51: 195-207. PMID 8809944  1
1996 Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science (New York, N.Y.). 273: 1875-7. PMID 8791595  1
1996 Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 16: 423-9. PMID 8789957 DOI: 10.1016/S0896-6273(00)80060-4  1
1996 Aleksandrov A, Velimirovic B, Clapham DE. Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. Biophysical Journal. 70: 2680-7. PMID 8744305 DOI: 10.1016/S0006-3495(96)79837-5  1
1996 Clapham DE. TRP is cracked but is CRAC TRP? Neuron. 16: 1069-72. PMID 8663982 DOI: 10.1016/S0896-6273(00)80132-4  1
1996 Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. Science (New York, N.Y.). 272: 1950-3. PMID 8658170  1
1996 Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE. The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. Febs Letters. 379: 31-7. PMID 8566224 DOI: 10.1016/0014-5793(95)01465-9  1
1996 Clapham DE. The G-protein nanomachine. Nature. 379: 297-9. PMID 8552180 DOI: 10.1038/379297a0  1
1995 Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. The Biochemical Journal. 312: 955-9. PMID 8554544  1
1995 Stehno-Bittel L, Krapivinsky G, Krapivinsky L, Perez-Terzic C, Clapham DE. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. The Journal of Biological Chemistry. 270: 30068-74. PMID 8530411  1
1995 Stehno-Bittel L, Perez-Terzic C, Clapham DE. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science (New York, N.Y.). 270: 1835-8. PMID 8525380  1
1995 Krapivinsky G, Gordon EA, Wickman K, Velimirović B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 374: 135-41. PMID 7877685 DOI: 10.1038/374135a0  1
1995 Clapham DE. Calcium signaling. Cell. 80: 259-68. PMID 7834745 DOI: 10.1016/0092-8674(95)90408-5  1
1995 Clapham DE. Intracellular calcium. Replenishing the stores. Nature. 375: 634-5. PMID 7791893 DOI: 10.1038/375634a0  1
1995 Hedin KE, Appleby MW, Clapham DE. Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. Immunology. 84: 183-92. PMID 7750993  1
1995 Clapham DE, Sneyd J. Intracellular calcium waves. Advances in Second Messenger and Phosphoprotein Research. 30: 1-24. PMID 7695987  1
1995 Wickman KD, Clapham DE. G-protein regulation of ion channels. Current Opinion in Neurobiology. 5: 278-85. PMID 7580149 DOI: 10.1016/0959-4388(95)80039-5  1
1995 Stehno-Bittel L, Lückhoff A, Clapham DE. Calcium release from the nucleus by InsP3 receptor channels. Neuron. 14: 163-7. PMID 7530018 DOI: 10.1016/0896-6273(95)90250-3  1
1995 Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. The Journal of Biological Chemistry. 270: 28777-9. PMID 7499400  1
1995 Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. The Journal of Biological Chemistry. 270: 29059-62. PMID 7493925 DOI: 10.1074/jbc.270.49.29059  1
1995 Wickman K, Clapham DE. Ion channel regulation by G proteins. Physiological Reviews. 75: 865-85. PMID 7480165  1
1994 Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE. Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. Cell. 76: 439-48. PMID 8313467 DOI: 10.1016/0092-8674(94)90109-0  1
1994 Clapham DE. Direct G protein activation of ion channels? Annual Review of Neuroscience. 17: 441-64. PMID 8210183 DOI: 10.1146/annurev.ne.17.030194.002301  1
1994 Girard S, Clapham DE. Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. Methods in Cell Biology. 40: 263-84. PMID 8201979 DOI: 10.1016/S0091-679X(08)61118-8  1
1994 Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. The Journal of General Physiology. 103: 153-79. PMID 8189203  1
1994 Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 368: 255-7. PMID 8145826 DOI: 10.1038/368255a0  1
1994 Clapham DE. Signal transduction. Why testicles are cool. Nature. 371: 109-10. PMID 8072540 DOI: 10.1038/371109a0  1
1994 Lückhoff A, Clapham DE. Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophysical Journal. 67: 177-82. PMID 7918985 DOI: 10.1016/S0006-3495(94)80467-9  1
1993 Ackerman MJ, Clapham DE. Cardiac chloride channels. Trends in Cardiovascular Medicine. 3: 23-8. PMID 21244967 DOI: 10.1016/1050-1738(93)90024-Z  0.6
1993 Clapham DE, Lechleiter JD, Girard S. Intracellular waves observed by confocal microscopy from Xenopus oocytes. Advances in Second Messenger and Phosphoprotein Research. 28: 161-5. PMID 8398398  1
1993 Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cellular Signalling. 5: 505-18. PMID 8312128 DOI: 10.1016/0898-6568(93)90046-O  1
1991 Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. The Journal of General Physiology. 98: 921-39. PMID 1765763  0.6
1991 Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. The Journal of Membrane Biology. 123: 49-54. PMID 1723103 DOI: 10.1007/BF01993962  1
1991 Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 88: 7892-5. PMID 1715584  1
1990 Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. Mayo Clinic Proceedings. 65: 1127-43. PMID 1697015  1
1989 Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. PflüGers Archiv : European Journal of Physiology. 414: 492-4. PMID 2571974 DOI: 10.1007/BF00585062  1
1989 Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 337: 557-60. PMID 2492640 DOI: 10.1038/337557a0  1
1988 Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. The American Journal of Physiology. 254: H192-7. PMID 2827524  1
1988 Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 85: 5814-8. PMID 2457901  1
1988 Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension. 11: 563-72. PMID 2455686  1
1988 Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circulation Research. 62: 1059-64. PMID 2454760  1
1987 Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 325: 321-6. PMID 2433589 DOI: 10.1038/325321a0  1
1984 Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophysical Journal. 45: 40-2. PMID 19431556  1
1984 Ypey DL, Clapham DE. Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proceedings of the National Academy of Sciences of the United States of America. 81: 3083-7. PMID 6328495  0.48
1984 Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. The Journal of Physiology. 347: 255-77. PMID 6200595 DOI: 10.1113/jphysiol.1984.sp015065  1
1984 Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. The Journal of Physiology. 353: 541-64. PMID 6090644 DOI: 10.1113/jphysiol.1984.sp015350  1
1982 Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. The Journal of Membrane Biology. 67: 63-71. PMID 7097756 DOI: 10.1007/BF01868648  1
1980 Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. The Journal of General Physiology. 75: 633-54. PMID 7391810  1
1979 Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. The Journal of Membrane Biology. 51: 75-96. PMID 522130 DOI: 10.1007/BF01869344  1
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