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David E. Clapham - Publications

Neurobiology Harvard Medical School/HHMI, Boston, MA, United States 
Ion channels and calcium signaling

182 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, ... ... Clapham DE, et al. Odontoblast TRPC5 channels signal cold pain in teeth. Science Advances. 7. PMID 33771873 DOI: 10.1126/sciadv.abf5567  0.638
2021 Liu B, Mundt N, Miller M, Clapham DE, Kirichok Y, Lishko PV. Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells. Journal of Visualized Experiments : Jove. PMID 33645583 DOI: 10.3791/62049  0.683
2020 Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513729 DOI: 10.1073/pnas.1922903117  0.405
2019 Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, ... ... Clapham DE, et al. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Science Advances. 5: eaaw7935. PMID 31355338 DOI: 10.1126/Sciadv.Aaw7935  0.407
2019 Blair NT, Carvacho I, Chaudhuri D, Clapham DE, DeCaen P, Delling M, Doerner JF, Fan L, Ha K, Jordt SE, Julius D, Kahle KT, Liu B, McKemy D, Nilius B, et al. Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f78/2019.4  0.828
2019 Chung J, Clapham DE, Garbers DL, Ren D. CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f70/2019.4  0.365
2018 Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. PMID 30108148 DOI: 10.1073/Pnas.1810719115  0.44
2018 Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J. Structure of the mouse TRPC4 ion channel. Nature Communications. 9: 3102. PMID 30082700 DOI: 10.1038/s41467-018-05247-9  0.409
2018 Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Cryo-EM structure of the polycystin 2-l1 ion channel. Elife. 7. PMID 30004384 DOI: 10.7554/Elife.36931  0.379
2018 Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full-length human TRPM4. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463718 DOI: 10.1073/pnas.1722038115  0.376
2018 Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 7. PMID 29443690 DOI: 10.7554/Elife.33183  0.432
2018 Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Author response: Cryo-EM structure of the polycystin 2-l1 ion channel Elife. DOI: 10.7554/Elife.36931.026  0.365
2017 Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America. PMID 28696294 DOI: 10.1073/Pnas.1707380114  0.322
2017 Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Elife. 6. PMID 28226241 DOI: 10.7554/Elife.23082  0.338
2017 Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SY, Clapham DE, Benavides F, Geha RS. LRRC8A-dependent volume regulated anion channel activity is dispensable for T cell development and function. The Journal of Allergy and Clinical Immunology. PMID 28192143 DOI: 10.1016/J.Jaci.2016.12.974  0.349
2016 Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 167: 763-773.e11. PMID 27768895 DOI: 10.1016/J.Cell.2016.09.048  0.414
2016 DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 5. PMID 27348301 DOI: 10.7554/Elife.13413  0.422
2016 Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. PMID 27007841 DOI: 10.1038/Nature17426  0.324
2016 Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. The Embo Journal. PMID 26873592 DOI: 10.15252/Embj.201593285  0.419
2016 Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chemical Senses. PMID 26843529 DOI: 10.1093/Chemse/Bjv071  0.774
2016 Sula A, DeCaen P, Naylor C, Zanatta G, Bagneris C, Clapham DE, Pryde D, Wallace B. Sodium Channel/Ligand Complex Structures as a Guide for Rational Drug Design Biophysical Journal. 110: 33a. DOI: 10.1016/J.Bpj.2015.11.248  0.418
2015 Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. Acs Chemical Biology. PMID 26674547 DOI: 10.1021/Acschembio.5B00748  0.404
2015 Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 57: 166-73. PMID 25498309 DOI: 10.1016/j.ceca.2014.11.007  0.339
2015 Naylor CE, Bagneris C, DeCaen PG, Clapham DE, Wallace B. Sodium Ion Coordination in the Selectivity Filter of a Voltage-Gated Sodium Channel Biophysical Journal. 108: 490a. DOI: 10.1016/J.Bpj.2014.11.2681  0.421
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 3. PMID 25385530 DOI: 10.7554/Elife.04387  0.44
2014 Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Molecular Biology and Evolution. 31: 2735-40. PMID 25063443 DOI: 10.1093/molbev/msu218  0.33
2014 Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proceedings of the National Academy of Sciences of the United States of America. 111: 8428-33. PMID 24850863 DOI: 10.1073/Pnas.1406855111  0.433
2014 Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 157: 808-22. PMID 24813608 DOI: 10.1016/J.Cell.2014.02.056  0.379
2014 Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochemical and Biophysical Research Communications. 449: 367-9. PMID 24792175 DOI: 10.1016/J.Bbrc.2014.04.141  0.338
2014 Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Reports. 6: 1122-8. PMID 24630989 DOI: 10.1016/J.Celrep.2014.02.015  0.31
2014 Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. Jama Neurology. 71: 640-5. PMID 24615367 DOI: 10.1001/Jamaneurol.2014.21  0.519
2014 Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3653-67. PMID 24599464 DOI: 10.1523/Jneurosci.2274-13.2014  0.389
2014 Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. The Journal of General Physiology. 143: 67-73. PMID 24344246 DOI: 10.1085/jgp.201311096  0.3
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Author response: Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus Elife. DOI: 10.7554/Elife.04387.019  0.382
2014 Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity Neurosurgery. 61: 214. DOI: 10.1227/01.Neu.0000452440.75411.82  0.621
2014 DeCaen PG, Delling M, Vien TN, Clapham DE. Corrigendum: Direct recording and molecular identification of the calcium channel of primary cilia Nature. 513: 266. DOI: 10.1038/Nature13631  0.384
2014 Bagnéris C, Naylor CE, DeCaen PG, Clapham DE, Pryde D, Wallace B. Structure/Function Insights into Eukaryotic Channel Blocker Binding Sites in a Prokaryotic Sodium Channel Biophysical Journal. 106: 36a. DOI: 10.1016/J.Bpj.2013.11.273  0.431
2014 Shim S, Chung J, Zhuang X, Clapham DE. Structurally Distinct Ca2+ Domains of Sperm Flagella Modulate Hyperactivated Motility Biophysical Journal. 106: 436a. DOI: 10.1016/J.Bpj.2013.11.2454  0.371
2013 DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 504: 315-8. PMID 24336289 DOI: 10.1038/Nature12832  0.44
2013 Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Reports. 5: 1375-86. PMID 24316078 DOI: 10.1016/J.Celrep.2013.11.007  0.416
2013 Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (New York, N.Y.). 342: 1379-82. PMID 24231807 DOI: 10.1126/Science.1242993  0.34
2013 Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nature Communications. 4: 2465. PMID 24051986 DOI: 10.1038/Ncomms3465  0.392
2013 Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proceedings of the National Academy of Sciences of the United States of America. 110: E3037-46. PMID 23878236 DOI: 10.1073/Pnas.1311865110  0.369
2013 Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. The Journal of General Physiology. 142: 113-26. PMID 23858001 DOI: 10.1085/Jgp.201310996  0.612
2013 Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2: e00704. PMID 23755363 DOI: 10.7554/Elife.00704  0.391
2013 Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 128: 101-14. PMID 23734001 DOI: 10.1161/Circulationaha.112.000768  0.343
2013 Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 6364-9. PMID 23542377 DOI: 10.1073/Pnas.1214667110  0.441
2013 Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods in Enzymology. 525: 59-83. PMID 23522465 DOI: 10.1016/B978-0-12-397944-5.00004-3  0.662
2013 Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Current Biology : Cb. 23: 443-52. PMID 23453951 DOI: 10.1016/j.cub.2013.02.007  0.307
2013 Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 152: 778-90. PMID 23394946 DOI: 10.1016/J.Cell.2013.01.023  0.658
2013 Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Research. 23: 409-22. PMID 23247626 DOI: 10.1038/Cr.2012.173  0.418
2013 Chung J, Shim S, Zhuang X, Clapham DE. Catsper Channel Organizes and Regulates Calcium Signaling Molecules in Spermatozoa Biophysical Journal. 104: 633a. DOI: 10.1016/J.Bpj.2012.11.3501  0.41
2013 Sah R, Mesirca P, Mason X, Van den Boogert M, Bates-Withers C, Rosen J, Mably J, Mangoni M, Clapham DE. The Ion Channel-Kinase, TRPM7, is Required for Cardiac Automaticity Biophysical Journal. 104: 379a. DOI: 10.1016/J.Bpj.2012.11.2109  0.377
2012 Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151: 372-83. PMID 23063126 DOI: 10.1016/J.Cell.2012.08.036  0.793
2012 Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, ... ... Clapham DE, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151: 96-110. PMID 23021218 DOI: 10.1016/J.Cell.2012.08.034  0.305
2012 Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Developmental Cell. 22: 1149-62. PMID 22698280 DOI: 10.1016/J.Devcel.2012.04.006  0.741
2012 Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 486: 130-4. PMID 22678295 DOI: 10.1038/Nature11054  0.421
2012 Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proceedings of the National Academy of Sciences of the United States of America. 109: 7888-92. PMID 22547824 DOI: 10.1073/pnas.1205869109  0.794
2012 Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience. 15: 565-73. PMID 22388960 DOI: 10.1038/Nn.3059  0.528
2012 Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 109: E225-33. PMID 22203997 DOI: 10.1073/Pnas.1120033109  0.55
2012 Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annual Review of Physiology. 74: 453-75. PMID 22017176 DOI: 10.1146/Annurev-Physiol-020911-153258  0.769
2012 Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Molecular Biology and Evolution. 29: 91-100. PMID 21680871 DOI: 10.1093/molbev/msr149  0.308
2012 Wang X, Zhang X, Dong X, Samie M, Li X, Shen D, Cheng X, Goschka A, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. Novel Na+-Selective Channels in the Lysosome Biophysical Journal. 102: 105a. DOI: 10.1016/J.Bpj.2011.11.590  0.764
2012 Chung J, Shim S, Zhuang X, Clapham DE. Super-Resolution Imaging Reveals a Multi-Array Arrangement of Catsper Channel on the Sperm Tail Biophysical Journal. 102: 681a. DOI: 10.1016/J.Bpj.2011.11.3702  0.414
2012 Stotz SC, Keating MB, Clapham DE. Drosophila Bestrophin 1 is a Swell Activated Chloride Channel Biophysical Journal. 102: 550a. DOI: 10.1016/J.Bpj.2011.11.2999  0.464
2011 Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proceedings of the National Academy of Sciences of the United States of America. 108: 19492-7. PMID 22109551 DOI: 10.1073/Pnas.1117485108  0.411
2011 Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, et al. Melanopsin signalling in mammalian iris and retina. Nature. 479: 67-73. PMID 22051675 DOI: 10.1038/Nature10567  0.3
2011 Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proceedings of the National Academy of Sciences of the United States of America. 108: 18114-9. PMID 22025699 DOI: 10.1073/Pnas.1115387108  0.81
2011 Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 108: 14342-7. PMID 21831833 DOI: 10.1073/pnas.1111695108  0.431
2011 Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Advances in Experimental Medicine and Biology. 704: 173-83. PMID 21290295 DOI: 10.1007/978-94-007-0265-3_9  0.374
2011 Wickman K, Hedin KE, Perez‐Terzic CM, Krapivinsky GB, Stehno‐Bittel L, Velimirovic B, Clapham DE. Mechanisms of Transmembrane Signaling Comprehensive Physiology. 689-742. DOI: 10.1002/Cphy.Cp140118  0.577
2010 Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacological Reviews. 62: 381-404. PMID 20716668 DOI: 10.1124/pr.110.002725  0.505
2010 Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MS, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nature Structural & Molecular Biology. 17: 869-75. PMID 20543828 DOI: 10.1038/Nsmb.1826  0.716
2010 Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, ... Clapham DE, et al. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 141: 331-43. PMID 20403327 DOI: 10.1016/J.Cell.2010.03.013  0.558
2010 Carvacho I, Ramsey IS, Clapham DE. A Single S4 Arginine is Sufficient for Voltage Sensitivity in the Hv1 Proton Channel Biophysical Journal. 98: 622a. DOI: 10.1016/J.BPJ.2009.12.3403  0.715
2009 Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 137: 761-72. PMID 19450521 DOI: 10.1016/J.Cell.2009.03.039  0.379
2009 Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Science Signaling. 2: ra21. PMID 19436059 DOI: 10.1126/Scisignal.2000146  0.765
2009 Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. The Journal of General Physiology. 133: 525-46. PMID 19398778 DOI: 10.1085/jgp.200810153  0.8
2009 Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proceedings of the National Academy of Sciences of the United States of America. 106: 7642-7. PMID 19372380 DOI: 10.1073/pnas.0902761106  0.789
2009 Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nature Protocols. 4: 174-96. PMID 19180088 DOI: 10.1038/Nprot.2008.223  0.762
2009 Ramsey IS, Carvacho I, Mokrab Y, Sansom MS, Clapham DE. H+ Permeation in Hv1 Voltage-gated Proton Channels Biophysical Journal. 96: 661a. DOI: 10.1016/J.Bpj.2008.12.3495  0.734
2009 Carvacho I, Ramsey IS, Clapham DE. Voltage and proton gradient sensing in Hv1 proton channels Biophysical Journal. 96: 484a. DOI: 10.1016/J.BPJ.2008.12.2495  0.744
2008 Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. Plos One. 3: e3569. PMID 18974790 DOI: 10.1371/journal.pone.0003569  0.435
2008 Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (New York, N.Y.). 322: 756-60. PMID 18974357 DOI: 10.1126/Science.1163493  0.357
2008 Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. The International Journal of Developmental Biology. 52: 607-13. PMID 18649274 DOI: 10.1387/Ijdb.072554Bn  0.662
2008 Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America. 105: 8304-8. PMID 18539771 DOI: 10.1073/pnas.0800881105  0.642
2008 Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. Plos One. 3: e2082. PMID 18461159 DOI: 10.1371/Journal.Pone.0002082  0.445
2008 Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. The Journal of Physiology. 586: 2477-86. PMID 18356202 DOI: 10.1113/jphysiol.2007.149427  0.743
2007 Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology (Reading, England). 153: 4027-38. PMID 18048917 DOI: 10.1099/Mic.0.2007/012070-0  0.356
2007 Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 18321-6. PMID 17989217 DOI: 10.1073/Pnas.0709096104  0.579
2007 Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. The Journal of Biological Chemistry. 282: 18945-52. PMID 17478420 DOI: 10.1074/Jbc.M701083200  0.738
2007 Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proceedings of the National Academy of Sciences of the United States of America. 104: 7688-92. PMID 17460039 DOI: 10.1073/Pnas.0702018104  0.662
2007 Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America. 104: 1219-23. PMID 17227845 DOI: 10.1073/Pnas.0610286104  0.8
2006 Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. The Journal of Biological Chemistry. 281: 29897-904. PMID 16899456 DOI: 10.1074/Jbc.M605394200  0.425
2006 Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. The Embo Journal. 25: 2978-88. PMID 16763551 DOI: 10.1038/Sj.Emboj.7601186  0.66
2006 Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. The Journal of Biological Chemistry. 281: 22085-91. PMID 16754686 DOI: 10.1074/Jbc.M603316200  0.32
2006 Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 440: 1213-6. PMID 16554753 DOI: 10.1038/Nature04700  0.815
2006 Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 439: 737-40. PMID 16467839 DOI: 10.1038/Nature04417  0.662
2006 Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annual Review of Physiology. 68: 619-47. PMID 16460286 DOI: 10.1146/annurev.physiol.68.040204.100431  0.762
2006 Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circulation Research. 98: 245-53. PMID 16357306 DOI: 10.1161/01.Res.0000200179.29375.Cc  0.66
2005 Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacological Reviews. 57: 509-26. PMID 16382105 DOI: 10.1124/Pr.57.4.11  0.421
2005 Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. Pharmacological Reviews. 57: 451-4. PMID 16382101 DOI: 10.1124/pr.57.4.7  0.414
2005 Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacological Reviews. 57: 427-50. PMID 16382100 DOI: 10.1124/Pr.57.4.6  0.438
2005 Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8924-37. PMID 16192383 DOI: 10.1523/Jneurosci.2574-05.2005  0.798
2005 Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, ... ... Clapham DE, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nature Genetics. 37: 739-44. PMID 15924139 DOI: 10.1038/Ng1592  0.382
2005 Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Molecular and Cellular Biology. 25: 2632-43. PMID 15767669 DOI: 10.1128/Mcb.25.7.2632-2643.2005  0.765
2005 Moore JE, Runnels LW, Greka A, Navarro B, Clapham DE. 225 THE CALCIUM-PERMEABLE ION CHANNEL TRPM7 MAY PLAY A ROLE IN CELL MOTILITY AND WOUND REPAIR IN RAT CARDIAC FIBROBASTS Journal of Investigative Medicine. 53: S292.4-S292. DOI: 10.2310/6650.2005.00006.224  0.657
2004 Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 43: 563-74. PMID 15312654 DOI: 10.1016/j.neuron.2004.08.003  0.302
2004 Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nature Cell Biology. 6: 709-20. PMID 15258588 DOI: 10.1038/Ncb1150  0.818
2004 Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences of the United States of America. 101: 10566-71. PMID 15243157 DOI: 10.1073/Pnas.0402692101  0.397
2004 Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Current Opinion in Neurobiology. 14: 362-9. PMID 15194117 DOI: 10.1016/J.Conb.2004.05.003  0.706
2004 Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. Plos Biology. 2: E50. PMID 15024413 DOI: 10.1371/Journal.Pbio.0020050  0.577
2004 Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 427: 360-4. PMID 14737170 DOI: 10.1038/Nature02246  0.662
2004 Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. The Journal of Biological Chemistry. 279: 9532-8. PMID 14665618 DOI: 10.1074/Jbc.M313100200  0.658
2004 Bezzerides VJ, Clapham DE. Near membrane protein dynamics revealed by evanescent field microscopy Proceedings of Spie - the International Society For Optical Engineering. 5467: 326-337. DOI: 10.1117/12.548399  0.647
2003 Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacological Reviews. 55: 591-6. PMID 14657417 DOI: 10.1124/Pr.55.4.6  0.46
2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/Pr.55.4.9  0.44
2003 Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proceedings of the National Academy of Sciences of the United States of America. 100: 14864-8. PMID 14657352 DOI: 10.1073/Pnas.2536658100  0.73
2003 Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 40: 775-84. PMID 14622581 DOI: 10.1016/S0896-6273(03)00645-7  0.311
2003 Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nature Neuroscience. 6: 837-45. PMID 12858178 DOI: 10.1038/Nn1092  0.807
2003 Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Developmental Cell. 4: 561-74. PMID 12689594 DOI: 10.1016/S1534-5807(03)00087-X  0.777
2003 Catterall WA, Chandy KG, Clapham DE, Gutman GA, Hofmann F, Harmar AJ, Abernethy DR, Spedding M. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels Pharmacological Reviews. 55: 573-574. DOI: 10.1124/Pr.55.4.5  0.403
2002 Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. The Journal of General Physiology. 120: 845-53. PMID 12451053 DOI: 10.1085/Jgp.20028699  0.705
2002 Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 418: 181-6. PMID 12077604 DOI: 10.1038/Nature00882  0.799
2002 Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nature Cell Biology. 4: 329-36. PMID 11941371 DOI: 10.1038/Ncb781  0.462
2002 Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene. 284: 241-50. PMID 11891065 DOI: 10.1016/S0378-1119(01)00884-8  0.644
2002 Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, et al. A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell. 9: 229-31. PMID 11864597 DOI: 10.1016/S1097-2765(02)00448-3  0.654
2001 Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science (New York, N.Y.). 294: 2372-5. PMID 11743207 DOI: 10.1126/Science.1065635  0.705
2001 Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 98: 12527-31. PMID 11675491 DOI: 10.1073/Pnas.221454998  0.745
2001 Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 413: 603-9. PMID 11595941 DOI: 10.1038/35098027  0.709
2001 Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. Journal of the American College of Cardiology. 37: 2136-43. PMID 11419900 DOI: 10.1016/S0735-1097(01)01304-3  0.561
2001 Hsu Sf, O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. Journal of Immunology (Baltimore, Md. : 1950). 166: 6126-33. PMID 11342632 DOI: 10.4049/Jimmunol.166.10.6126  0.328
2001 Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 410: 705-9. PMID 11287959 DOI: 10.1038/35070596  0.585
2001 Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (New York, N.Y.). 291: 1043-7. PMID 11161216 DOI: 10.1126/Science.1058519  0.462
2000 Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. The Journal of Biological Chemistry. 275: 36211-6. PMID 10956667 DOI: 10.1074/Jbc.M007087200  0.672
2000 Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5608-15. PMID 10908597 DOI: 10.1523/Jneurosci.20-15-05608.2000  0.63
2000 Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). The Journal of Biological Chemistry. 275: 29709-16. PMID 10900209 DOI: 10.1074/jbc.M004989200  0.425
2000 Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. The Journal of Biological Chemistry. 275: 12363-6. PMID 10777517 DOI: 10.1074/jbc.275.17.12363  0.583
1999 Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Annals of the New York Academy of Sciences. 868: 386-98. PMID 10414308 DOI: 10.1111/j.1749-6632.1999.tb11300.x  0.642
1999 Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron. 23: 149-57. PMID 10402201 DOI: 10.1016/S0896-6273(00)80761-8  0.362
1999 Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. The Journal of Membrane Biology. 169: 123-9. PMID 10341034 DOI: 10.1007/s002329900524  0.455
1999 Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. The Journal of Biological Chemistry. 274: 2571-82. PMID 9891030 DOI: 10.1074/Jbc.274.4.2571  0.645
1999 Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophysical Journal. 76: 246-52. PMID 9876138 DOI: 10.1016/S0006-3495(99)77193-6  0.666
1998 Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nature Neuroscience. 1: 114-8. PMID 10195125 DOI: 10.1038/363  0.33
1998 Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. The Journal of Biological Chemistry. 273: 16946-52. PMID 9642257 DOI: 10.1074/jbc.273.27.16946  0.376
1998 Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. Neuron. 20: 995-1005. PMID 9620703 DOI: 10.1016/S0896-6273(00)80480-8  0.442
1998 Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. Cell Calcium. 23: 91-101. PMID 9601604 DOI: 10.1016/S0143-4160(98)90107-5  0.305
1998 Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. The Journal of Biological Chemistry. 273: 10811-4. PMID 9556550 DOI: 10.1074/Jbc.273.18.10811  0.596
1998 Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Molecular and Cellular Biology. 18: 1652-9. PMID 9488482 DOI: 10.1128/Mcb.18.3.1652  0.441
1998 Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 20: 103-14. PMID 9459446 DOI: 10.1016/S0896-6273(00)80438-9  0.598
1997 Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 40: 402-8. PMID 9073507 DOI: 10.1006/geno.1996.4600  0.595
1997 Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics. 40: 395-401. PMID 9073506 DOI: 10.1006/Geno.1997.4599  0.62
1996 Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology. 35: 831-9. PMID 8938714 DOI: 10.1016/0028-3908(96)00132-3  0.384
1996 Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 16: 423-9. PMID 8789957 DOI: 10.1016/S0896-6273(00)80060-4  0.415
1996 Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. Science (New York, N.Y.). 272: 1950-3. PMID 8658170 DOI: 10.1126/science.272.5270.1950  0.406
1995 Krapivinsky G, Gordon EA, Wickman K, Velimirović B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 374: 135-41. PMID 7877685 DOI: 10.1038/374135A0  0.654
1995 Wickman KD, Clapham DE. G-protein regulation of ion channels. Current Opinion in Neurobiology. 5: 278-85. PMID 7580149 DOI: 10.1016/0959-4388(95)80039-5  0.679
1995 Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. The Journal of Biological Chemistry. 270: 28777-9. PMID 7499400 DOI: 10.1074/Jbc.270.48.28777  0.639
1995 Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. The Journal of Biological Chemistry. 270: 29059-62. PMID 7493925 DOI: 10.1074/Jbc.270.49.29059  0.603
1995 Wickman K, Clapham DE. Ion channel regulation by G proteins. Physiological Reviews. 75: 865-85. PMID 7480165 DOI: 10.1152/Physrev.1995.75.4.865  0.675
1994 Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. The Journal of General Physiology. 103: 153-79. PMID 8189203 DOI: 10.1085/Jgp.103.2.153  0.669
1994 Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 368: 255-7. PMID 8145826 DOI: 10.1038/368255A0  0.597
1993 Girard S, Clapham D. Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx Science. 260: 229-232. PMID 8385801 DOI: 10.1126/Science.8385801  0.308
1992 Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 356: 238-41. PMID 1313151 DOI: 10.1038/356238A0  0.665
1991 Lechleiter J, Girard S, Clapham D, Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors Nature. 350: 505-508. PMID 1849616 DOI: 10.1038/350505A0  0.304
1991 Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. The Journal of General Physiology. 98: 921-39. PMID 1765763 DOI: 10.1085/Jgp.98.5.921  0.432
1991 Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. The Journal of Membrane Biology. 123: 49-54. PMID 1723103 DOI: 10.1007/BF01993962  0.627
1991 Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 88: 7892-5. PMID 1715584 DOI: 10.1073/Pnas.88.17.7892  0.322
1990 Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. Mayo Clinic Proceedings. 65: 1127-43. PMID 1697015 DOI: 10.1016/S0025-6196(12)62726-8  0.419
1990 Lechleiter JD, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. The Embo Journal. 9: 4381-4390. DOI: 10.1002/J.1460-2075.1990.Tb07888.X  0.304
1989 Kim D, Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science (New York, N.Y.). 244: 1174-6. PMID 2727703 DOI: 10.1126/Science.2727703  0.421
1989 Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. Pflã¼Gers Archiv : European Journal of Physiology. 414: 492-4. PMID 2571974 DOI: 10.1007/BF00585062  0.413
1989 Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 337: 557-60. PMID 2492640 DOI: 10.1038/337557A0  0.37
1988 Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 85: 5814-8. PMID 2457901 DOI: 10.1073/Pnas.85.16.5814  0.333
1988 Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circulation Research. 62: 1059-64. PMID 2454760 DOI: 10.1161/01.Res.62.6.1059  0.328
1988 Fish RD, Sperti G, Colucci WS, Clapham DE. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circulation Research. 62: 1049-54. PMID 2452033 DOI: 10.1161/01.RES.62.5.1049  0.342
1984 Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophysical Journal. 45: 40-2. PMID 19431556 DOI: 10.1016/S0006-3495(84)84099-0  0.583
1984 Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. The Journal of Physiology. 347: 255-77. PMID 6200595 DOI: 10.1113/jphysiol.1984.sp015065  0.547
1984 Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. The Journal of Physiology. 353: 541-64. PMID 6090644 DOI: 10.1113/jphysiol.1984.sp015350  0.576
1982 Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. The Journal of Membrane Biology. 67: 63-71. PMID 7097756 DOI: 10.1007/BF01868648  0.583
1980 Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. The Journal of General Physiology. 75: 633-54. PMID 7391810 DOI: 10.1085/jgp.75.6.633  0.558
1979 Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. The Journal of Membrane Biology. 51: 75-96. PMID 522130 DOI: 10.1007/BF01869344  0.566
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