Florian Holsboer - Publications

Affiliations: 
MPIP Munich, München, Bayern, Germany 

219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Barakat AK, Scholl C, Steffens M, Brandenburg K, Ising M, Lucae S, Holsboer F, Laje G, Kalayda GV, Jaehde U, Stingl JC. Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients. Translational Psychiatry. 10: 210. PMID 32612257 DOI: 10.1038/S41398-020-00900-8  0.302
2019 Ising M, Maccarrone G, Brückl T, Scheuer S, Hennings J, Holsboer F, Turck CW, Uhr M, Lucae S. FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression. International Journal of Molecular Sciences. 20. PMID 30678080 DOI: 10.3390/Ijms20030485  0.34
2018 Inkster B, Simmons A, Cole J, Schoof E, Linding R, Nichols T, Muglia P, Holsboer F, Saemann P, McGuffin P, Fu C, Miskowiak K, Matthews PM, Zai G, Nicodemus K. Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder. Psychiatric Genetics. PMID 30080747 DOI: 10.1097/Ypg.0000000000000203  0.301
2017 Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, ... ... Holsboer F, et al. Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. Plos Biology. 15: e2002690. PMID 29283992 DOI: 10.1371/Journal.Pbio.2002690  0.31
2017 Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, et al. Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29079688 DOI: 10.1523/Jneurosci.3487-16.2017  0.327
2017 Pawlowski MA, Gazea M, Wollweber B, Dresler M, Holsboer F, Keck ME, Steiger A, Adamczyk M, Mikoteit T. Heart rate variability and cordance in rapid eye movement sleep as biomarkers of depression and treatment response. Journal of Psychiatric Research. 92: 64-73. PMID 28411417 DOI: 10.1016/J.Jpsychires.2017.03.026  0.301
2015 Santarelli S, Wagner KV, Labermaier C, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Holsboer F, Chen A, Müller MB, Schmidt MV. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress (Amsterdam, Netherlands). 1-8. PMID 26585320 DOI: 10.3109/10253890.2015.1105211  0.342
2015 Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biological Psychiatry. PMID 26410355 DOI: 10.1016/J.Biopsych.2015.08.005  0.598
2015 Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, ... Holsboer F, et al. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9007-16. PMID 26085626 DOI: 10.1523/Jneurosci.4024-14.2015  0.31
2015 Dine J, Ionescu IA, Avrabos C, Yen YC, Holsboer F, Landgraf R, Schmidt U, Eder M. Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one. Plos One. 10: e0120272. PMID 25830625 DOI: 10.1371/Journal.Pone.0120272  0.302
2015 Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OF, Spengler D. Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics : Official Journal of the Dna Methylation Society. 10: 247-57. PMID 25793778 DOI: 10.1080/15592294.2015.1017199  0.31
2015 Adamczyk M, Gazea M, Wollweber B, Holsboer F, Dresler M, Steiger A, Pawlowski M. Cordance derived from REM sleep EEG as a biomarker for treatment response in depression--a naturalistic study after antidepressant medication. Journal of Psychiatric Research. 63: 97-104. PMID 25772006 DOI: 10.1016/J.Jpsychires.2015.02.007  0.311
2015 Zaba M, Kirmeier T, Ionescu IA, Wollweber B, Buell DR, Gall-Kleebach DJ, Schubert CF, Novak B, Huber C, Köhler K, Holsboer F, Pütz B, Müller-Myhsok B, Höhne N, Uhr M, et al. Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients. Psychoneuroendocrinology. 55: 102-15. PMID 25745955 DOI: 10.1016/J.Psyneuen.2015.02.005  0.303
2015 Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM. Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating. Psychoneuroendocrinology. 53: 16-28. PMID 25575243 DOI: 10.1016/J.Psyneuen.2014.12.005  0.323
2015 Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology. 52: 43-58. PMID 25459892 DOI: 10.1016/J.Psyneuen.2014.11.005  0.313
2014 Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, Balsevich G, Deussing JM, Kloiber S, Lucae S, Holsboer F, et al. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. Plos Medicine. 11: e1001755. PMID 25386878 DOI: 10.1371/Journal.Pmed.1001755  0.34
2014 Heinzmann JM, Kloiber S, Ebling-Mattos G, Bielohuby M, Schmidt MV, Palme R, Holsboer F, Uhr M, Ising M, Touma C. Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach. Psychoneuroendocrinology. 49: 229-43. PMID 25123105 DOI: 10.1055/S-0035-1547627  0.35
2014 Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, ... ... Holsboer F, et al. A polymorphism in the Crhr1 gene determines stress vulnerability in male mice. Endocrinology. 155: 2500-10. PMID 24773341 DOI: 10.1210/En.2013-1986  0.311
2014 Santarelli S, Lesuis SL, Wang XD, Wagner KV, Hartmann J, Labermaier C, Scharf SH, Müller MB, Holsboer F, Schmidt MV. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 907-18. PMID 24589292 DOI: 10.1016/J.Euroneuro.2014.02.002  0.306
2014 Breitenstein B, Scheuer S, Holsboer F. Are there meaningful biomarkers of treatment response for depression? Drug Discovery Today. 19: 539-61. PMID 24561326 DOI: 10.1016/J.Drudis.2014.02.002  0.306
2014 Sotnikov SV, Markt PO, Malik V, Chekmareva NY, Naik RR, Sah A, Singewald N, Holsboer F, Czibere L, Landgraf R. Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala. Translational Psychiatry. 4: e359. PMID 24518397 DOI: 10.1038/Tp.2013.127  0.304
2014 Albu S, Romanowski CP, Letizia Curzi M, Jakubcakova V, Flachskamm C, Gassen NC, Hartmann J, Schmidt MV, Schmidt U, Rein T, Holsboer F, Hausch F, Paez-Pereda M, Kimura M. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. Journal of Sleep Research. 23: 176-85. PMID 24354785 DOI: 10.1111/Jsr.12112  0.327
2013 Menke A, Klengel T, Rubel J, Brückl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder EB. Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes, Brain, and Behavior. 12: 289-96. PMID 23406438 DOI: 10.1111/Gbb.12026  0.331
2013 Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neuroscience. 16: 33-41. PMID 23201972 DOI: 10.1038/Nn.3275  0.307
2013 Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, ... ... Holsboer F, et al. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 653-62. PMID 23026132 DOI: 10.1016/J.Euroneuro.2012.08.010  0.325
2013 Uher R, Tansey KE, Rietschel M, Henigsberg N, Maier W, Mors O, Hauser J, Placentino A, Souery D, Farmer A, Aitchison KJ, Craig I, McGuffin P, Lewis CM, Ising M, ... ... Holsboer F, et al. Common genetic variation and antidepressant efficacy in major depressive disorder: A meta-analysis of three genome-wide pharmacogenetic studies American Journal of Psychiatry. 170: 207-217. DOI: 10.1176/Appi.Ajp.2012.12020237  0.306
2013 Erhardt A, Lucae S, Ising M, Holsboer F, Binder E. Association of PACAP and PACAPR1 gene variants with unipolar depression and panic disorder Pharmacopsychiatry. 46. DOI: 10.1055/S-0033-1353350  0.302
2013 Pawlowski M, Gazea M, Adamczyk M, Wollweber B, Holsboer F, Steiger A, Dresler M. Cordance as a biomarker in sleep-EEG for treatment response in depression Pharmacopsychiatry. 46. DOI: 10.1055/S-0033-1353284  0.315
2012 Gonik M, Frank E, Keßler MS, Czamara D, Bunck M, Yen YC, Pütz B, Holsboer F, Bettecken T, Landgraf R, Müller-Myhsok B, Touma C, Czibere L. The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety. Bmc Genomics. 13: 579. PMID 23114097 DOI: 10.1186/1471-2164-13-579  0.326
2012 Ganea K, Menke A, Schmidt MV, Lucae S, Rammes G, Liebl C, Harbich D, Sterlemann V, Storch C, Uhr M, Holsboer F, Binder EB, Sillaber I, Müller MB. Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response. Translational Psychiatry. 2: e177. PMID 23092981 DOI: 10.1038/Tp.2012.104  0.324
2012 Wagner KV, Marinescu D, Hartmann J, Wang XD, Labermaier C, Scharf SH, Liebl C, Uhr M, Holsboer F, Müller MB, Schmidt MV. Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2797-808. PMID 22871917 DOI: 10.1038/Npp.2012.150  0.31
2012 Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Müller MB, Schmidt MV. Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. The European Journal of Neuroscience. 36: 2360-7. PMID 22672268 DOI: 10.1111/J.1460-9568.2012.08148.X  0.305
2012 Graf C, Kuehne C, Panhuysen M, Puetz B, Weber P, Holsboer F, Wurst W, Deussing JM. Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells. Molecular and Cellular Endocrinology. 362: 29-38. PMID 22659651 DOI: 10.1016/J.Mce.2012.05.007  0.303
2012 Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 37: 2009-21. PMID 22641006 DOI: 10.1016/J.Psyneuen.2012.04.017  0.328
2012 Schmidt MV, Paez-Pereda M, Holsboer F, Hausch F. The prospect of FKBP51 as a drug target. Chemmedchem. 7: 1351-9. PMID 22581765 DOI: 10.1002/Cmdc.201200137  0.305
2012 Knapman A, Kaltwasser SF, Martins-de-Souza D, Holsboer F, Landgraf R, Turck CW, Czisch M, Touma C. Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism. The European Journal of Neuroscience. 35: 412-22. PMID 22288479 DOI: 10.1111/J.1460-9568.2011.07968.X  0.303
2012 Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1455-64. PMID 22237309 DOI: 10.1038/Npp.2011.331  0.304
2012 Dedic N, Touma C, Romanowski CP, Schieven M, Kühne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M, Deussing JM. Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice. Cellular and Molecular Neurobiology. 32: 815-28. PMID 22198557 DOI: 10.1007/S10571-011-9784-0  0.324
2012 Ditzen C, Tang N, Jastorff AM, Teplytska L, Yassouridis A, Maccarrone G, Uhr M, Bronisch T, Miller CA, Holsboer F, Turck CW. Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1013-25. PMID 22169944 DOI: 10.1038/Npp.2011.285  0.304
2012 Menke A, Sämann P, Kloiber S, Czamara D, Lucae S, Hennings J, Heck A, Kohli MA, Czisch M, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes. Psychoneuroendocrinology. 37: 565-75. PMID 21962378 DOI: 10.1016/J.Psyneuen.2011.09.003  0.323
2012 Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, et al. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 62: 332-9. PMID 21839098 DOI: 10.1016/J.Neuropharm.2011.07.041  0.337
2011 Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, et al. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biological Psychiatry. 70: 928-36. PMID 21907973 DOI: 10.1016/J.Biopsych.2011.07.023  0.338
2011 Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, Widner R, Kühne C, Panhuysen M, Hambsch B, Rieder G, ... ... Holsboer F, et al. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. Plos One. 6: e23604. PMID 21897848 DOI: 10.1371/Journal.Pone.0023604  0.309
2011 Zimmermann P, Brückl T, Nocon A, Pfister H, Binder EB, Uhr M, Lieb R, Moffitt TE, Caspi A, Holsboer F, Ising M. Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. The American Journal of Psychiatry. 168: 1107-16. PMID 21865530 DOI: 10.1176/Appi.Ajp.2011.10111577  0.316
2011 Bonfiglio JJ, Inda C, Refojo D, Holsboer F, Arzt E, Silberstein S. The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved. Neuroendocrinology. 94: 12-20. PMID 21576930 DOI: 10.1159/000328226  0.331
2011 Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, ... ... Holsboer F, et al. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron. 70: 252-65. PMID 21521612 DOI: 10.1016/J.Neuron.2011.04.005  0.304
2011 Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M, Yassouridis A. Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression. Bmc Neuroscience. 12: 29. PMID 21435199 DOI: 10.1186/1471-2202-12-29  0.327
2011 Paez-Pereda M, Hausch F, Holsboer F. Corticotropin releasing factor receptor antagonists for major depressive disorder. Expert Opinion On Investigational Drugs. 20: 519-35. PMID 21395482 DOI: 10.1517/13543784.2011.565330  0.323
2011 Inkster B, Rao AW, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Tozzi F, Muglia P, Merlo-Pich E, Matthews PM. Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. 21: 375-82. PMID 20977527 DOI: 10.1111/J.1552-6569.2010.00515.X  0.305
2011 von Wolff G, Avrabos C, Stepan J, Wurst W, Deussing JM, Holsboer F, Eder M. Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation. Journal of Psychiatric Research. 45: 256-61. PMID 20619419 DOI: 10.1016/J.Jpsychires.2010.06.007  0.309
2011 Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Bauer J, Suslow T, Kugel H, Heindel W, Baumann C, Klauke B, Jacob C, Maier W, ... ... Holsboer F, et al. Neuropeptide S receptor gene -- converging evidence for a role in panic disorder. Molecular Psychiatry. 16: 938-48. PMID 20603625 DOI: 10.1038/Mp.2010.81  0.3
2011 Dunlop BW, Betancourt Y, Binder EB, Heim C, Holsboer F, Ising M, McKenzie M, Mletzko T, Pfister H, Nemeroff CB, Craighead WE, Mayberg HS. Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder. Journal of Psychiatric Research. 45: 24-8. PMID 20488460 DOI: 10.1016/J.Jpsychires.2010.04.020  0.303
2011 Pawlowski M, Dresler M, Holsboer F, Steiger A. P.2.a.012 Cordance as a biomarker in sleep-EEG for depression: responders versus nonresponders: a naturalistic study after antidepressant medication European Neuropsychopharmacology. 21: S360-S361. DOI: 10.1016/S0924-977X(11)70576-4  0.306
2010 Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F, et al. Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16949-58. PMID 21159965 DOI: 10.1523/Jneurosci.4668-10.2010  0.319
2010 Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein. Bmc Genomics. 11: 546. PMID 20932279 DOI: 10.1186/1471-2164-11-546  0.3
2010 Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, et al. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nature Reviews. Neuroscience. 11: 718-26. PMID 20852655 DOI: 10.1038/Nrn2912  0.462
2010 Heinzmann JM, Thoeringer CK, Knapman A, Palme R, Holsboer F, Uhr M, Landgraf R, Touma C. Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study. Journal of Neuroendocrinology. 22: 1187-97. PMID 20735798 DOI: 10.1111/J.1365-2826.2010.02062.X  0.322
2010 Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, ... ... Holsboer F, et al. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9103-16. PMID 20610744 DOI: 10.1523/Jneurosci.1049-10.2010  0.304
2010 Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, ... ... Holsboer F, et al. Genome-wide association study of major recurrent depression in the U.K. population. The American Journal of Psychiatry. 167: 949-57. PMID 20516156 DOI: 10.1176/Appi.Ajp.2010.09091380  0.302
2010 Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Touma C. Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice. Neurobiology of Learning and Memory. 94: 145-52. PMID 20451634 DOI: 10.1016/J.Nlm.2010.04.010  0.309
2010 Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M. Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep. 33: 427-36. PMID 20394311 DOI: 10.1093/Sleep/33.4.427  0.326
2010 Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1583-92. PMID 20237460 DOI: 10.1038/Npp.2010.30  0.335
2010 Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. Neuroimage. 53: 908-17. PMID 20219685 DOI: 10.1016/J.Neuroimage.2010.02.065  0.3
2010 Kohli MA, Salyakina D, Pfennig A, Lucae S, Horstmann S, Menke A, Kloiber S, Hennings J, Bradley BB, Ressler KJ, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Archives of General Psychiatry. 67: 348-59. PMID 20124106 DOI: 10.1001/Archgenpsychiatry.2009.201  0.308
2010 Knapman A, Heinzmann JM, Hellweg R, Holsboer F, Landgraf R, Touma C. Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders. Journal of Psychiatric Research. 44: 566-75. PMID 20035953 DOI: 10.1016/J.Jpsychires.2009.11.014  0.312
2010 Kimura M, Müller-Preuss P, Lu A, Wiesner E, Flachskamm C, Wurst W, Holsboer F, Deussing JM. Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Molecular Psychiatry. 15: 154-65. PMID 19455148 DOI: 10.1038/Mp.2009.46  0.329
2010 Thoeringer CK, Erhardt A, Sillaber I, Mueller MB, Ohl F, Holsboer F, Keck ME. Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice. Journal of Psychopharmacology (Oxford, England). 24: 733-43. PMID 19346277 DOI: 10.1177/0269881109103091  0.311
2010 Kloiber S, Kohli MA, Brueckl T, Ripke S, Ising M, Uhr M, Menke A, Unschuld PG, Horstmann S, Salyakina D, Muller-Myhsok B, Binder EB, Holsboer F, Lucae S. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular Psychiatry. 15: 736-47. PMID 19125159 DOI: 10.1038/Mp.2008.142  0.316
2009 Silberstein S, Vogl AM, Refojo D, Senin SA, Wurst W, Holsboer F, Deussing JM, Arzt E. Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions. Neuroscience. 159: 610-7. PMID 19361479 DOI: 10.1016/J.Neuroscience.2009.01.014  0.31
2009 Bunck M, Czibere L, Horvath C, Graf C, Frank E, Kessler MS, Murgatroyd C, Müller-Myhsok B, Gonik M, Weber P, Pütz B, Muigg P, Panhuysen M, Singewald N, Bettecken T, ... ... Holsboer F, et al. A hypomorphic vasopressin allele prevents anxiety-related behavior. Plos One. 4: e5129. PMID 19357765 DOI: 10.1371/Journal.Pone.0005129  0.31
2009 Touma C, Fenzl T, Ruschel J, Palme R, Holsboer F, Kimura M, Landgraf R. Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression. Plos One. 4: e4325. PMID 19177162 DOI: 10.1371/Journal.Pone.0004325  0.346
2009 Kalus S, Kneib T, Steiger A, Holsboer F, Yassouridis A. A new strategy to analyze possible association structures between dynamic nocturnal hormone activities and sleep alterations in humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R1216-27. PMID 19144755 DOI: 10.1152/Ajpregu.90530.2008  0.303
2009 Künzel HE, Ackl N, Hatzinger M, Held K, Holsboer-Trachsler E, Ising M, Kaschka W, Kasper S, Konstantinidis A, Sonntag A, Uhr M, Yassouridis A, Holsboer F, Steiger A. Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial. Journal of Psychiatric Research. 43: 702-10. PMID 19038406 DOI: 10.1016/J.Jpsychires.2008.10.004  0.301
2009 Risbrough VB, Geyer MA, Hauger RL, Coste S, Stenzel-Poore M, Wurst W, Holsboer F. CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1494-503. PMID 19020499 DOI: 10.1038/Npp.2008.205  0.313
2009 Horstmann S, Dose T, Lucae S, Kloiber S, Menke A, Hennings J, Spieler D, Uhr M, Holsboer F, Ising M. Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action. Psychoneuroendocrinology. 34: 238-48. PMID 18926641 DOI: 10.1016/J.Psyneuen.2008.09.004  0.325
2009 Binder EB, Künzel HE, Nickel T, Kern N, Pfennig A, Majer M, Uhr M, Ising M, Holsboer F. HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients. Psychoneuroendocrinology. 34: 99-109. PMID 18829172 DOI: 10.1016/J.Psyneuen.2008.08.018  0.325
2009 Erhardt A, Müller MB, Rödel A, Welt T, Ohl F, Holsboer F, Keck ME. Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775. Journal of Psychopharmacology (Oxford, England). 23: 31-9. PMID 18515457 DOI: 10.1177/0269881108089813  0.314
2009 Zimmermann P, Brückl T, Pfister H, Lieb R, Wittchen H, Holsboer F, Ising M, Binder E, Uhr M, Nocon A. The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240261  0.311
2009 Unschuld P, Ising M, Roeske D, Erhardt A, Specht M, Ripke S, Uhr M, Kloiber S, Müller-Myhsok B, Holsboer F, Binder E. Polymorphisms in the gene encoding the neuropeptide galanin are associated with HPA-axis dysregulation and symptome severity in major-depressive- and anxiety-disorder patients Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240238  0.31
2008 Schmidt U, Holsboer F, Rein T. Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases. Proceedings of the National Academy of Sciences of the United States of America. 105: E101; author reply E. PMID 19020101 DOI: 10.1073/Pnas.0809354105  0.326
2008 Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement AB, Behl C. Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience. 156: 712-21. PMID 18708129 DOI: 10.1016/J.Neuroscience.2008.07.034  0.31
2008 Sillaber I, Panhuysen M, Henniger MS, Ohl F, Kühne C, Pütz B, Pohl T, Deussing JM, Paez-Pereda M, Holsboer F. Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology. 200: 557-72. PMID 18629477 DOI: 10.1007/S00213-008-1232-6  0.302
2008 Kronsbein HC, Jastorff AM, Maccarrone G, Stalla G, Wurst W, Holsboer F, Turck CW, Deussing JM. CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells. Molecular and Cellular Endocrinology. 292: 1-10. PMID 18582531 DOI: 10.1016/J.Mce.2008.05.017  0.304
2008 Friess E, Modell S, Brunner H, Tagaya H, Lauer CJ, Holsboer F, Ising M. The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects. European Archives of Psychiatry and Clinical Neuroscience. 258: 285-91. PMID 18504636 DOI: 10.1007/S00406-007-0795-2  0.302
2008 Touma C, Bunck M, Glasl L, Nussbaumer M, Palme R, Stein H, Wolferstätter M, Zeh R, Zimbelmann M, Holsboer F, Landgraf R. Mice selected for high versus low stress reactivity: a new animal model for affective disorders. Psychoneuroendocrinology. 33: 839-62. PMID 18502051 DOI: 10.1016/J.Psyneuen.2008.03.013  0.34
2008 Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Molecular Psychiatry. 13: 1028-42. PMID 18475271 DOI: 10.1038/Mp.2008.51  0.314
2008 Ströhle A, Scheel M, Modell S, Holsboer F. Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder. Journal of Psychiatric Research. 42: 1185-8. PMID 18342888 DOI: 10.1016/J.Jpsychires.2008.01.015  0.309
2008 Friess E, Schmid D, Modell S, Brunner H, Lauer CJ, Holsboer F, Ising M. Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders. Journal of Psychiatric Research. 42: 1154-62. PMID 18281062 DOI: 10.1016/J.Jpsychires.2008.01.005  0.335
2008 Schmid DA, Brunner H, Lauer CJ, Uhr M, Yassouridis A, Holsboer F, Friess E. Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression. Journal of Psychiatric Research. 42: 991-9. PMID 18226817 DOI: 10.1016/J.Jpsychires.2007.12.003  0.327
2008 Steiner MA, Marsicano G, Nestler EJ, Holsboer F, Lutz B, Wotjak CT. Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology. 33: 54-67. PMID 17976922 DOI: 10.1016/J.Psyneuen.2007.09.008  0.323
2008 Yu S, Holsboer F, Almeida OF. Neuronal actions of glucocorticoids: focus on depression. The Journal of Steroid Biochemistry and Molecular Biology. 108: 300-9. PMID 17933520 DOI: 10.1016/J.Jsbmb.2007.09.014  0.31
2008 Steiner MA, Wanisch K, Monory K, Marsicano G, Borroni E, Bächli H, Holsboer F, Lutz B, Wotjak CT. Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice. The Pharmacogenomics Journal. 8: 196-208. PMID 17684478 DOI: 10.1038/Sj.Tpj.6500466  0.305
2008 Unschuld PG, Ising M, Erhardt A, Lucae S, Kohli M, Kloiber S, Salyakina D, Thoeringer CK, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME. Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. Journal of Affective Disorders. 105: 177-84. PMID 17573119 DOI: 10.1016/J.Jad.2007.05.006  0.316
2007 Thoeringer CK, Sillaber I, Roedel A, Erhardt A, Mueller MB, Ohl F, Holsboer F, Keck ME. The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice. Psychoneuroendocrinology. 32: 746-57. PMID 17583438 DOI: 10.1016/J.Psyneuen.2007.05.005  0.306
2007 Himmerich H, Zimmermann P, Ising M, Kloiber S, Lucae S, Kunzel HE, Binder EB, Holsboer F, Uhr M. Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment. Neuropsychobiology. 55: 28-35. PMID 17556850 DOI: 10.1159/000103573  0.33
2007 Reppermund S, Zihl J, Lucae S, Horstmann S, Kloiber S, Holsboer F, Ising M. Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biological Psychiatry. 62: 400-6. PMID 17188252 DOI: 10.1016/J.Biopsych.2006.09.027  0.302
2007 Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, Künzel HE, Pfennig A, Uhr M, Holsboer F. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? Biological Psychiatry. 62: 47-54. PMID 17123470 DOI: 10.1016/J.Biopsych.2006.07.039  0.322
2007 Steiner M, Marsicano G, Nestler E, Holsboer F, Lutz B, Wotjak C. Endocannabinoid signaling modulates HPA axis activity in the mouse – implications for depression disorders Pharmacopsychiatry. 40. DOI: 10.1055/S-2007-991731  0.306
2006 Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Müller MB, de Kloet ER. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. The European Journal of Neuroscience. 24: 2291-8. PMID 17042789 DOI: 10.1111/J.1460-9568.2006.05121.X  0.53
2006 Schmidt MV, Levine S, Alam S, Harbich D, Sterlemann V, Ganea K, de Kloet ER, Holsboer F, Müller MB. Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse. Journal of Neuroendocrinology. 18: 865-74. PMID 17026536 DOI: 10.1111/J.1365-2826.2006.01482.X  0.505
2006 Nguyen NK, Keck ME, Hetzenauer A, Thoeringer CK, Wurst W, Deussing JM, Holsboer F, Müller MB, Singewald N. Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge. Psychopharmacology. 188: 374-85. PMID 16953386 DOI: 10.1007/S00213-006-0513-1  0.302
2006 Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, ... ... Holsboer F, et al. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Molecular Psychiatry. 11: 1003-15. PMID 16924268 DOI: 10.1038/Sj.Mp.4001884  0.307
2006 Schüssler P, Yassouridis A, Uhr M, Kluge M, Weikel J, Holsboer F, Steiger A. Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation. American Journal of Physiology. Endocrinology and Metabolism. 291: E549-56. PMID 16912060 DOI: 10.1152/Ajpendo.00641.2005  0.307
2006 Erhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Pütz B, Uhr M, Binder EB, Holsboer F, Keck ME. Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2515-22. PMID 16841071 DOI: 10.1038/Sj.Npp.1301168  0.32
2006 van Rossum EF, Binder EB, Majer M, Koper JW, Ising M, Modell S, Salyakina D, Lamberts SW, Holsboer F. Polymorphisms of the glucocorticoid receptor gene and major depression. Biological Psychiatry. 59: 681-8. PMID 16580345 DOI: 10.1016/J.Biopsych.2006.02.007  0.328
2006 Binder E, Lucae S, Salyakina D, Lichtner P, Meitinger T, Bondy B, Wochnik G, Rein T, Holsboer F, Müller-Myhsok B. SNPs in FKBP5 determine a novel subtype of depression characterized by rapid response to antidepressant treatment European Neuropsychopharmacology. 16: S75. DOI: 10.1016/S0924-977X(06)80089-1  0.301
2005 Ising M, Künzel HE, Binder EB, Nickel T, Modell S, Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 1085-93. PMID 15950349 DOI: 10.1016/J.Pnpbp.2005.03.014  0.326
2005 Keck ME, Ohl F, Holsboer F, Müller MB. Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders. Neuroscience and Biobehavioral Reviews. 29: 867-89. PMID 15899517 DOI: 10.1016/J.Neubiorev.2005.03.003  0.347
2005 de Kloet ER, Joëls M, Holsboer F. Stress and the brain: from adaptation to disease. Nature Reviews. Neuroscience. 6: 463-75. PMID 15891777 DOI: 10.1038/Nrn1683  0.512
2005 Refojo D, Echenique C, Müller MB, Reul JM, Deussing JM, Wurst W, Sillaber I, Paez-Pereda M, Holsboer F, Arzt E. Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proceedings of the National Academy of Sciences of the United States of America. 102: 6183-8. PMID 15833812 DOI: 10.1073/Pnas.0502070102  0.31
2005 Keck ME, Sartori SB, Welt T, Müller MB, Ohl F, Holsboer F, Landgraf R, Singewald N. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of Neurochemistry. 92: 1170-9. PMID 15715667 DOI: 10.1111/J.1471-4159.2004.02953.X  0.307
2005 Post A, Ohl F, Almeida OF, Binder EB, Rücker M, Welt S, Binder E, Holsboer F, Sillaber I. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Psychopharmacology. 180: 150-8. PMID 15682302 DOI: 10.1007/S00213-004-2134-X  0.323
2005 Schmidt MV, Schmidt M, Levine S, Oitzl MS, van der Mark M, Müller MB, Holsboer F, de Kloet ER. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Endocrinology. 146: 1458-64. PMID 15591147 DOI: 10.1210/En.2004-1042  0.521
2005 Künzel HE, Ising M, Zobel AW, Nickel T, Ackl N, Sonntag A, Holsboer F, Uhr M. Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression. Journal of Psychiatric Research. 39: 173-7. PMID 15589565 DOI: 10.1016/J.Jpsychires.2004.06.006  0.306
2005 Unschuld P, Ising M, Erhardt A, Lucae S, Welt T, Kloiber S, Kern N, Salyakina D, Binder E, Brückl T, Uhr M, Müller-Myhsok B, Holsboer F, Keck M. Polymorphisms in the serotonin receptor gene HTR2A modulate disease severity and susceptibility for anxiety disorders but not depression and are associated with specific personality traits Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918859  0.312
2005 Lu A, Steiner M, Engelholm M, Engelholm M, Wotjak C, Holsboer F, Wurst W, Deussing J. Site-specific overexpression of corticotropin-releasing hormone (CRH) in the mouse brain – modelling central CRH system hyperactivity Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918770  0.329
2004 Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, ... ... Holsboer F, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature Genetics. 36: 1319-25. PMID 15565110 DOI: 10.1038/Ng1479  0.332
2004 Kalisch R, Salomé N, Platzer S, Wigger A, Czisch M, Sommer W, Singewald N, Heilig M, Berthele A, Holsboer F, Landgraf R, Auer DP. High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats. Neuroimage. 23: 382-91. PMID 15325386 DOI: 10.1016/J.Neuroimage.2004.06.012  0.309
2004 Murck H, Held K, Ziegenbein M, Künzel H, Holsboer F, Steiger A. Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG Psychoneuroendocrinology. 29: 1205-1211. PMID 15219645 DOI: 10.1016/J.Psyneuen.2004.02.006  0.311
2004 Held K, Künzel H, Ising M, Schmid DA, Zobel A, Murck H, Holsboer F, Steiger A. Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression. Journal of Psychiatric Research. 38: 129-36. PMID 14757326 DOI: 10.1016/S0022-3956(03)00076-1  0.316
2004 Friess E, Tagaya H, Grethe C, Trachsel L, Holsboer F. Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 598-604. PMID 14647485 DOI: 10.1038/Sj.Npp.1300362  0.301
2004 Wigger A, Sánchez MM, Mathys KC, Ebner K, Frank E, Liu D, Kresse A, Neumann ID, Holsboer F, Plotsky PM, Landgraf R. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1-14. PMID 12942143 DOI: 10.1038/Sj.Npp.1300290  0.336
2003 Künzel HE, Zobel AW, Nickel T, Ackl N, Uhr M, Sonntag A, Ising M, Holsboer F. Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects. Journal of Psychiatric Research. 37: 525-33. PMID 14563384 DOI: 10.1016/S0022-3956(03)00070-0  0.327
2003 Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. Journal of Psychiatric Research. 37: 463-70. PMID 14563377 DOI: 10.1016/S0022-3956(03)00054-2  0.317
2003 Müller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kühn R, Reul JM, Holsboer F, Wurst W. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nature Neuroscience. 6: 1100-7. PMID 12973355 DOI: 10.1038/Nn1123  0.333
2003 Künzel HE, Binder EB, Nickel T, Ising M, Fuchs B, Majer M, Pfennig A, Ernst G, Kern N, Schmid DA, Uhr M, Holsboer F, Modell S. Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2169-78. PMID 12931142 DOI: 10.1038/Sj.Npp.1300280  0.321
2003 Oshima A, Flachskamm C, Reul JM, Holsboer F, Linthorst AC. Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2148-59. PMID 12915860 DOI: 10.1038/Sj.Npp.1300267  0.32
2003 Müller MB, Keck ME, Binder EB, Kresse AE, Hagemeyer TP, Landgraf R, Holsboer F, Uhr M. ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1991-9. PMID 12888779 DOI: 10.1038/Sj.Npp.1300257  0.32
2003 Schmidt MV, Schmidt M, Oitzl MS, Müller MB, Ohl F, Wurst W, Holsboer F, Levine S, De Kloet ER. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Neuroscience. 119: 589-95. PMID 12770571 DOI: 10.1016/S0306-4522(03)00097-6  0.53
2003 Bachmann CG, Linthorst AC, Holsboer F, Reul JM. Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1056-67. PMID 12700716 DOI: 10.1038/Sj.Npp.1300158  0.305
2003 Nickel T, Sonntag A, Schill J, Zobel AW, Ackl N, Brunnauer A, Murck H, Ising M, Yassouridis A, Steiger A, Zihl J, Holsboer F. Clinical and neurobiological effects of tianeptine and paroxetine in major depression. Journal of Clinical Psychopharmacology. 23: 155-68. PMID 12640217 DOI: 10.1097/00004714-200304000-00008  0.309
2003 Murck H, Nickel T, Künzel H, Antonijevic IA, Schill J, Zobel A, Steiger A, Sonntag A, Holsboer F. State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 348-58. PMID 12589388 DOI: 10.1038/Sj.Npp.1300029  0.314
2003 Keck ME, Welt T, Müller MB, Uhr M, Ohl F, Wigger A, Toschi N, Holsboer F, Landgraf R. Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 235-43. PMID 12589376 DOI: 10.1038/Sj.Npp.1300040  0.302
2002 Linthorst AC, Peñalva RG, Flachskamm C, Holsboer F, Reul JM. Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism. The European Journal of Neuroscience. 16: 2441-52. PMID 12492439 DOI: 10.1046/J.1460-9568.2002.02400.X  0.337
2002 Müller MB, Holsboer F, Keck ME. Genetic modification of corticosteroid receptor signalling: Novel insights into pathophysiology and treatment strategies of human affective disorders Neuropeptides. 36: 117-131. PMID 12359503 DOI: 10.1054/Npep.2002.0896  0.342
2002 Peñalva RG, Flachskamm C, Zimmermann S, Wurst W, Holsboer F, Reul JM, Linthorst AC. Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice. Neuroscience. 109: 253-66. PMID 11801362 DOI: 10.1016/S0306-4522(01)00475-4  0.318
2002 Keck ME, Wigger A, Welt T, Müller MB, Gesing A, Reul JM, Holsboer F, Landgraf R, Neumann ID. Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 94-105. PMID 11751036 DOI: 10.1016/S0893-133X(01)00351-7  0.302
2001 Müller MB, Lucassen PJ, Yassouridis A, Hoogendijk WJ, Holsboer F, Swaab DF. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. The European Journal of Neuroscience. 14: 1603-12. PMID 11860455 DOI: 10.1046/J.0953-816X.2001.01784.X  0.311
2001 Preil J, Müller MB, Gesing A, Reul JM, Sillaber I, van Gaalen MM, Landgrebe J, Holsboer F, Stenzel-Poore M, Wurst W. Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology. 142: 4946-55. PMID 11606463 DOI: 10.1210/Endo.142.11.8507  0.316
2001 Müller MB, Preil J, Renner U, Zimmermann S, Kresse AE, Stalla GK, Keck ME, Holsboer F, Wurst W. Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation. Endocrinology. 142: 4150-3. PMID 11517194 DOI: 10.1210/Endo.142.9.8491  0.33
2001 Keck ME, Holsboer F. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders Peptides. 22: 835-844. PMID 11337098 DOI: 10.1016/S0196-9781(01)00398-9  0.341
2001 Steckler T, Rammes G, Sauvage M, Van Gaalen MM, Weis C, Zieglgänsberger W, Holsboer F. Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice Journal of Psychiatric Research. 35: 29-42. PMID 11287054 DOI: 10.1016/S0022-3956(00)00040-6  0.301
2001 Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology. 158: 453-68. PMID 11159183 DOI: 10.1016/S0002-9440(10)63988-0  0.51
2001 Schuld A, Kraus T, Haack M, Hinze-Selch D, Zobel AW, Holsboer F, Pollmächer T. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients Psychoneuroendocrinology. 26: 65-76. PMID 11070335 DOI: 10.1016/S0306-4530(00)00039-1  0.324
2001 Steckler T, Van Gaalen M, Sauvage M, Reul J, Stenzel-Poore M, Holsboer F. Genetically modified animals to analyse the abnormalities in the hypothalamic-pituitary-adrenal axis in depression European Neuropsychopharmacology. 11: S167-S168. DOI: 10.1016/S0924-977X(01)80102-4  0.309
2000 Reul JM, Bilang-Bleuel A, Droste S, Linthorst AC, Holsboer F, Gesing A. New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders. Zeitschrift Fã¼R Rheumatologie. 59: II/22-5. PMID 11155799 DOI: 10.1007/S003930070013  0.32
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Keck ME, Zimmermann S, Holsboer F, Wurst W. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Endocrinology. 141: 4262-9. PMID 11089561 DOI: 10.1210/Endo.141.11.7767  0.312
2000 Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C, Bilang-Bleuel A, Holsboer F, Linthorst AC. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. European Journal of Pharmacology. 405: 235-49. PMID 11033331 DOI: 10.1016/S0014-2999(00)00677-4  0.306
2000 Antonijevic IA, Murck H, Bohlhalter S, Frieboes R, Holsboer F, Steiger A. Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology. 39: 1474-1481. PMID 10818263 DOI: 10.1016/S0028-3908(00)00057-5  0.314
2000 Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmächer T. Dose-dependent effects of endotoxin on human sleep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R947-55. PMID 10749783 DOI: 10.1152/Ajpregu.2000.278.4.R947  0.306
2000 Neumann ID, Wigger A, Torner L, Holsboer F, Landgraf R. Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus. Journal of Neuroendocrinology. 12: 235-43. PMID 10718919 DOI: 10.1046/J.1365-2826.2000.00442.X  0.305
2000 Hatzinger M, Wotjak CT, Naruo T, Simchen R, Keck ME, Landgraf R, Holsboer F, Neumann ID. Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats. The Journal of Endocrinology. 164: 197-205. PMID 10657855 DOI: 10.1677/Joe.0.1640197  0.305
2000 Antonijevic I, Murck H, Frieboes R, Holsboer F, Steiger A. 264. Sleep-endocrine effects of GHRH in depression are sexually dimorphic Biological Psychiatry. 47: S80. DOI: 10.1016/S0006-3223(00)00528-X  0.3
1999 Frieboes R, Müller U, Murck H, Cramon DYv, Holsboer F, Steiger A. Nocturnal hormone secretion and the sleep EEG in patients several months after traumatic brain injury. Journal of Neuropsychiatry and Clinical Neurosciences. 11: 354-360. PMID 10440012 DOI: 10.1176/Jnp.11.3.354  0.315
1999 Landgraf R, Wigger A, Holsboer F, Neumann ID. Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour. Journal of Neuroendocrinology. 11: 405-7. PMID 10336720 DOI: 10.1046/J.1365-2826.1999.00342.X  0.309
1999 Schuld A, Mullington J, Hermann D, Hinze-Selch D, Fenzel T, Holsboer F, Pollmächer T. Effects of granulocyte colony-stimulating factor on night sleep in humans. The American Journal of Physiology. 276: R1149-55. PMID 10198397 DOI: 10.1152/Ajpregu.1999.276.4.R1149  0.305
1999 Antonijevic I, Murck H, Frieboes R, Steiger A, Holsboer F. Altered sleep-endocrine regulation in depression — effect of GHRH European Neuropsychopharmacology. 9: 251. DOI: 10.1016/S0924-977X(99)80237-5  0.323
1998 Heuser I, Bissette G, Dettling M, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Nemeroff CB, Holsboer F. Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment. Depression and Anxiety. 8: 71-9. PMID 9784981 DOI: 10.1002/(Sici)1520-6394(1998)8:2<71::Aid-Da5>3.0.Co;2-N  0.312
1998 Wiedemann K, Hirschmann M, Knaudt K, Rupprecht R, Seier FE, Holsboer F. Sleep endocrine effects of megestrol acetate in healthy men Journal of Neuroendocrinology. 10: 719-727. PMID 9744490 DOI: 10.1046/J.1365-2826.1998.00259.X  0.315
1998 Hemmeter U, Rothe B, Guldner J, Holsboer F, Steiger A. Effects of thyrotropin-releasing hormone on the sleep EEG and nocturnal hormone secretion in male volunteers. Neuropsychobiology. 38: 25-31. PMID 9701719 DOI: 10.1159/000026513  0.322
1998 Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520  0.327
1998 Wiedemann K, Lauer CJ, Hirschmann M, Knaudt K, Holsboer F. Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9458759 DOI: 10.1152/Ajpendo.1998.274.1.E139  0.31
1997 Guldner J, Schier T, Friess E, Colla M, Holsboer F, Steiger A. Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiology of Aging. 18: 491-5. PMID 9390775 DOI: 10.1016/S0197-4580(97)00106-1  0.309
1997 Barden N, Stec IS, Montkowski A, Holsboer F, Reul JM. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology. 66: 212-20. PMID 9380279 DOI: 10.1159/000127240  0.306
1997 Steiger A, Holsboer F. Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission. Psychiatry Research. 72: 81-8. PMID 9335199 DOI: 10.1016/S0165-1781(97)00097-8  0.332
1997 Bohlhalter S, Murck H, Holsboer F, Steiger A. Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects. Neurobiology of Aging. 18: 423-9. PMID 9330974 DOI: 10.1016/S0197-4580(97)00036-5  0.312
1997 Karanth S, Linthorst AC, Stalla GK, Barden N, Holsboer F, Reul JM. Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function. Endocrinology. 138: 3476-85. PMID 9231802 DOI: 10.1210/Endo.138.8.5331  0.316
1997 Sonntag A, Rothe B, Guldner J, Yassouridis A, Holsboer F, Steiger A. Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression. Depression. 4: 1-13. PMID 9160649 DOI: 10.1002/(Sici)1522-7162(1996)4:1<1::Aid-Depr1>3.0.Co;2-S  0.321
1997 Kellner M, Yassouridis A, Manz B, Steiger A, Holsboer F, Wiedemann K. Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression? Neuroendocrinology. 65: 284-90. PMID 9143000 DOI: 10.1159/000127186  0.346
1997 Schier T, Guldner J, Colla M, Holsboer F, Steiger A. Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. Journal of Neuroendocrinology. 9: 201-5. PMID 9089471 DOI: 10.1046/J.1365-2826.1997.00565.X  0.325
1997 Reul JM, Probst JC, Skutella T, Hirschmann M, Stec IS, Montkowski A, Landgraf R, Holsboer F. Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides. Neuroendocrinology. 65: 189-99. PMID 9088000 DOI: 10.1159/000127272  0.305
1996 Hatzinger M, Reul JM, Landgraf R, Holsboer F, Neumann I. Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging. Neuroendocrinology. 64: 349-56. PMID 8930935 DOI: 10.1159/000127138  0.305
1996 Murck H, Guldner J, Colla-Müller M, Frieboes RM, Schier T, Wiedemann K, Holsboer F, Steiger A. VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men. The American Journal of Physiology. 271: R905-11. PMID 8897980 DOI: 10.1152/Ajpregu.1996.271.4.R905  0.305
1996 Guldner J, Trachsel L, Kratschmayr C, Rothe B, Holsboer F, Steiger A. Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men. Psychopharmacology. 122: 115-21. PMID 8848526 DOI: 10.1007/Bf02246085  0.302
1995 Montkowski A, Barden N, Wotjak C, Stec I, Ganster J, Meaney M, Engelmann M, Reul JM, Landgraf R, Holsboer F. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. Journal of Neuroendocrinology. 7: 841-5. PMID 8748120 DOI: 10.1111/J.1365-2826.1995.Tb00724.X  0.319
1995 Holsboer F, Lauer CJ, Schreiber W, Krieg JC. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders Neuroendocrinology. 62: 340-347. PMID 8544947 DOI: 10.1159/000127023  0.326
1995 Steiger A, Guldner J, Lauer CJ, Meschenmoser C, Pollmächer T, Holsboer F. Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls. Psychopharmacology. 113: 334-8. PMID 7862842 DOI: 10.1007/Bf02245206  0.319
1995 Lauer CJ, Schreiber W, Holsboer F, Krieg JC. In Quest of Identifying Vulnerability Markers for Psychiatric Disorders by All-Night Polysomnography Archives of General Psychiatry. 52: 145-153. PMID 7848050 DOI: 10.1001/Archpsyc.1995.03950140063009  0.32
1995 Rothe B, Guldner J, Hohlfeldt E, Lauer CJ, Pollmächer T, Holsboer F, Steiger A. Effects of 5HT3 receptor antagonism by tropisetron on the sleep EEG and on nocturnal hormone secretion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 11: 101-6. PMID 7840861 DOI: 10.1038/Npp.1994.39  0.306
1995 Friess E, Trachsel L, Guldner J, Schier T, Steiger A, Holsboer F. DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. The American Journal of Physiology. 268: E107-13. PMID 7840167 DOI: 10.1152/Ajpendo.1995.268.1.E107  0.303
1995 Steiger A, Benkert O, Holsboer F. Effects of long-term treatment with the MAO-A inhibitor moclobemide on sleep EEG and nocturnal hormonal secretion in normal men. Neuropsychobiology. 30: 101-5. PMID 7800155 DOI: 10.1159/000119145  0.308
1995 Kellner M, Herzog L, Holsboer F, Wiedemann K. Circadian changes in the sensitivity of the corticotropin-releasing hormone-stimulated HPA system after arginine vasopressin and atrial natriuretic hormone in human male controls. Psychoneuroendocrinology. 20: 515-24. PMID 7675936 DOI: 10.1016/0306-4530(94)00070-Q  0.303
1995 Kellner M, Herzog L, Yassouridis A, Holsboer F, Wiedemann K. Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic. The American Journal of Psychiatry. 152: 1365-7. PMID 7653695 DOI: 10.1176/Ajp.152.9.1365  0.302
1995 Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology. 61: 584-9. PMID 7617137 DOI: 10.1159/000126883  0.31
1995 Friess E, Wiedemann K, Steiger A, Holsboer F. The hypothalamic-pituitary-adrenocortical system and sleep in man. Advances in Neuroimmunology. 5: 111-25. PMID 7496607 DOI: 10.1016/0960-5428(95)00003-K  0.305
1994 Friess E, V Bardeleben U, Wiedemann K, Lauer CJ, Holsboer F. Effects of pulsatile cortisol infusion on sleep-EEG and nocturnal growth hormone release in healthy men. Journal of Sleep Research. 3: 73-79. PMID 10607111 DOI: 10.1111/J.1365-2869.1994.Tb00110.X  0.312
1994 Schöbitz B, Holsboer F, Sutanto W, Gross G, Schönbaum E, de Kloet ER. Corticosterone modulates interleukin-evoked fever in the rat. Neuroendocrinology. 59: 387-95. PMID 8202220 DOI: 10.1159/000126682  0.478
1994 Wiegers GJ, Reul JM, Holsboer F, de Kloet ER. Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro. Endocrinology. 135: 2351-7. PMID 7988417 DOI: 10.1210/Endo.135.6.7988417  0.499
1994 Schöbitz B, Sutanto W, Carey MP, Holsboer F, de Kloet ER. Endotoxin and interleukin 1 decrease the affinity of hippocampal mineralocorticoid (type I) receptor in parallel to activation of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology. 60: 124-33. PMID 7969769 DOI: 10.1159/000126742  0.506
1994 Schöbitz B, De Kloet ER, Holsboer F. Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain. Progress in Neurobiology. 44: 397-432. PMID 7886232 DOI: 10.1016/0301-0082(94)90034-5  0.477
1994 Reul JM, Labeur MS, Grigoriadis DE, De Souza EB, Holsboer F. Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology. 60: 509-19. PMID 7845541 DOI: 10.1159/000126788  0.325
1994 Holsboer F, Grasser A, Friess E, Wiedemann K. Steroid effects on central neurons and implications for psychiatric and neurological disorders. Annals of the New York Academy of Sciences. 746: 345-59; discussion 3. PMID 7825889 DOI: 10.1111/J.1749-6632.1994.Tb39255.X  0.348
1994 Patchev VK, Shoaib M, Holsboer F, Almeida OFX. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus Neuroscience. 62: 265-271. PMID 7816204 DOI: 10.1016/0306-4522(94)90330-1  0.305
1993 Steiger A, Holsboer F, Benkert O. Studies of nocturnal penile tumescence and sleep electroencephalogram in patients with major depression and in normal controls. Acta Psychiatrica Scandinavica. 87: 358-63. PMID 8517177 DOI: 10.1111/J.1600-0447.1993.Tb03387.X  0.323
1993 Schöbitz B, Van Den Dobbelsteen M, Holsboer F, Sutanto W, De Kloet ER. Regulation of interleukin 6 gene expression in rat. Endocrinology. 132: 1569-76. PMID 8462455 DOI: 10.1210/endo.132.4.8462455  0.415
1993 Steiger A, von Bardeleben U, Guldner J, Lauer C, Rothe B, Holsboer F. The sleep EEG and nocturnal hormonal secretion studies on changes during the course of depression and on effects of CNS-active drugs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 17: 125-37. PMID 8416599 DOI: 10.1016/0278-5846(93)90037-S  0.333
1993 Steiger A, Trachsel L, Guldner J, Hemmeter U, Rothe B, Rupprecht R, Vedder H, Holsboer F. Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Research. 615: 267-74. PMID 8395958 DOI: 10.1016/0006-8993(93)90037-N  0.323
1993 Reul JM, Stec I, Söder M, Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology. 133: 312-20. PMID 8391426 DOI: 10.1210/Endo.133.1.8391426  0.301
1993 Steiger A, Gerken A, Benkert O, Holsboer F. Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 3: 117-26. PMID 8364347 DOI: 10.1016/0924-977X(93)90263-L  0.312
1993 Steiger A, Rupprecht R, Spengler D, Guldner J, Hemmeter U, Rothe B, Damm K, Holsboer F. Functional properties of deoxycorticosterone and spironolactone: Molecular characterization and effects on sleep-endocrine activity Journal of Psychiatric Research. 27: 275-284. PMID 8295159 DOI: 10.1016/0022-3956(93)90038-4  0.318
1993 Schöbitz B, de Kloet ER, Sutanto W, Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. The European Journal of Neuroscience. 5: 1426-35. PMID 8287192 DOI: 10.1111/J.1460-9568.1993.Tb00210.X  0.481
1993 Wiegers GJ, Croiset G, Reul JM, Holsboer F, de Kloet ER. Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro. The American Journal of Physiology. 265: E825-30. PMID 8279536 DOI: 10.1152/Ajpendo.1993.265.6.E825  0.489
1993 Garcia-Borreguero D, Lauer CJ, Ozdaglar A, Wiedemann K, Holsboer F, Krieg JC. Brofaromine in panic disorder: a pilot study with a new reversible inhibitor of monoamine oxidase-A. Pharmacopsychiatry. 25: 261-4. PMID 1494591 DOI: 10.1055/S-2007-1014418  0.302
1993 Lauer CJ, Krieg JC, Garcia-Borreguero D, Ozdaglar A, Holsboer F. Panic disorder and major depression: a comparative electroencephalographic sleep study. Psychiatry Research. 44: 41-54. PMID 1461946 DOI: 10.1016/0165-1781(92)90068-E  0.327
1993 Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology. 56: 566-73. PMID 1361964 DOI: 10.1159/000126275  0.313
1993 Steiger A, Sonntag A, Guldner J, Rothe B, Holsboer F. Changes in clinical symptoms, sleep EEG and nocturnal hormone secretion during treatment with trimipramine or imipramine — a double-blind comparison in patients with major depression European Neuropsychopharmacology. 3: 339-340. DOI: 10.1016/0924-977X(93)90119-7  0.32
1992 Steiger A, Guldner J, Knisatschek H, Rothe B, Lauer C, Holsboer F. Effects of an ACTH/MSH(4-9) analog (HOE 427) on the sleep EEG and nocturnal hormonal secretion in humans. Peptides. 12: 1007-10. PMID 1666179 DOI: 10.1016/0196-9781(91)90051-P  0.311
1992 Schöbitz B, Holsboer F, Kikkert R, Sutanto W, De Kloet ER. Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats. Endocrine Regulations. 26: 103-9. PMID 1308153  0.422
1992 Steiger A, Guldner J, Hemmeter U, Knisatschek H, Rothe B, Rupprecht R, Holsboer F. EFFECTS OF MINERALOCORTICOID RECEPTOR LIGANDS ON SLEEP EEG AND NOCTURNAL HORMONE SECRETION - STUDIES WITH DEOXYCORTICOSTERONE AND SPIRONOLACTONE Clinical Neuropharmacology. 15: 281B. DOI: 10.1097/00002826-199202001-00542  0.305
1992 Guldner J, Steiger A, Rothe B, Holsboer F. INFLUENCE OF THE PARTIAL BENZODIAZEPINE AGONIST BETAZENIL ON SLEEP-EEG AND NOCTURNAL SECRETION OF CORTISOL AND GROWTH HORMONE Clinical Neuropharmacology. 15: 28B. DOI: 10.1097/00002826-199202001-00052  0.302
1991 Steiger A, Bardeleben Uv, Wiedemann K, Holsboer F. Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission Journal of Psychiatric Research. 25: 169-177. PMID 1779414 DOI: 10.1016/0022-3956(91)90021-2  0.336
1990 Steiger A, Benkert O, Wöhrmann S, Steinseifer D, Holsboer F. Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls. Neuropsychobiology. 21: 71-5. PMID 2515468 DOI: 10.1159/000118555  0.319
1989 Steiger A, Bardeleben Uv, Herth T, Holsboer F. Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery Journal of Affective Disorders. 16: 189-195. PMID 2522118 DOI: 10.1016/0165-0327(89)90073-6  0.326
1988 Holsboer F, Bardeleben Uv, Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology. 48: 32-38. PMID 3262835 DOI: 10.1159/000124986  0.31
1987 Steiger A, Holsboer F, Benkert O. Effects of brofaremine (CGP 11 305A), a short-acting, reversible, and selective inhibitor of MAO-A on sleep, nocturnal penile tumescence and nocturnal hormonal secretion in three healthy volunteers. Psychopharmacology. 92: 110-4. PMID 3110820 DOI: 10.1007/Bf00215489  0.301
1986 Holsboer F, Philipp M, Steiger A, Gerken A. Multisteroid analysis after DST in depressed patients--a controlled study. Journal of Affective Disorders. 10: 241-9. PMID 2943779 DOI: 10.1016/0165-0327(86)90011-X  0.305
1984 Holsboer F, Gerken A, Steiger A, Fass V. Mean 14.00-17.00 h plasma cortisol concentration and its relationship to the 1 mg-dexamethasone suppression response in depressives and controls. Acta Psychiatrica Scandinavica. 69: 383-90. PMID 6730994 DOI: 10.1111/J.1600-0447.1984.Tb02509.X  0.327
1984 Holsboer F, Gerken A, Steiger A, Benkert O, Müller OA, Stalla GK. Corticotropin-releasing-factor induced pituitary-adrenal response in depression. Lancet (London, England). 1: 55. PMID 6140385 DOI: 10.1016/S0140-6736(84)90225-3  0.308
1984 Holsboer F, Müller OA, Doerr HG, Sippell WG, Stalla GK, Gerken A, Steiger A, Boll E, Benkert O. ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression. Psychoneuroendocrinology. 9: 147-60. PMID 6089243 DOI: 10.1016/0306-4530(84)90034-9  0.316
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