Wolfgang Wurst - Publications

Affiliations: 
Helmholtz Zentrum München 

288 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. Embo Reports. e50241. PMID 32929860 DOI: 10.15252/Embr.202050241  0.376
2020 Heppt J, Wittmann MT, Schäffner I, Billmann C, Zhang J, Vogt-Weisenhorn D, Prakash N, Wurst W, Taketo MM, Lie DC. β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. The Embo Journal. e104472. PMID 32929771 DOI: 10.15252/Embj.2020104472  0.32
2020 Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, ... ... Wurst W, et al. A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Science Translational Medicine. 12. PMID 32908004 DOI: 10.1126/Scitranslmed.Aau3960  0.31
2020 Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, ... ... Wurst W, et al. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. The Journal of Clinical Investigation. PMID 32780722 DOI: 10.1172/Jci136363  0.333
2020 LaClair KD, Zhou Q, Michaelsen M, Wefers B, Brill MS, Janjic A, Rathkolb B, Farny D, Cygan M, de Angelis MH, Wurst W, Neumann M, Enard W, Misgeld T, Arzberger T, et al. Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathologica. PMID 32562018 DOI: 10.1007/S00401-020-02176-0  0.32
2020 Ignatova VV, Stolz P, Kaiser S, Gustafsson TH, Lastres PR, Sanz-Moreno A, Cho YL, Amarie OV, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Marschall S, Kraiger M, Garrett L, ... ... Wurst W, et al. The rRNA mA methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes & Development. PMID 32217665 DOI: 10.1101/Gad.333369.119  0.323
2020 Garrett L, Chang YJ, Niedermeier KM, Heermann T, Enard W, Fuchs H, Gailus-Durner V, Angelis MH, Huttner WB, Wurst W, Hölter SM. A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons. Translational Psychiatry. 10: 66. PMID 32066665 DOI: 10.1038/S41398-020-0686-0  0.366
2020 Torres-Mejía E, Trümbach D, Kleeberger C, Dornseifer U, Orschmann T, Bäcker T, Brenke JK, Hadian K, Wurst W, López-Schier H, Desbordes SC. Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis. Scientific Reports. 10: 1984. PMID 32029747 DOI: 10.1038/S41598-019-56877-Y  0.31
2020 Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, et al. Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nature Structural & Molecular Biology. PMID 32015554 DOI: 10.1038/S41594-019-0370-3  0.301
2020 Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, ... ... Wurst W, et al. Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nature Medicine. PMID 31988462 DOI: 10.1038/S41591-019-0738-2  0.314
2019 Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, et al. Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31908000 DOI: 10.1096/Fj.201902347R  0.304
2019 Baumann P, Schriever SC, Kullmann S, Zimprich A, Feuchtinger A, Amarie O, Peter A, Walch A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Wurst W, Tschöp MH, Heni M, Hölter SM, et al. Dusp8 affects hippocampal size and behavior in mice and humans. Scientific Reports. 9: 19483. PMID 31862894 DOI: 10.1038/S41598-019-55527-7  0.347
2019 Lucienne M, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, da Silva-Buttkus P, Garrett L, Hölter SM, Mayer-Kuckuk P, Rathkolb B, Rozman J, Spielmann N, Treise I, Busch DH, Klopstock T, ... ... Wurst W, et al. In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165622. PMID 31770620 DOI: 10.1016/J.Bbadis.2019.165622  0.359
2019 Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, et al. Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nature Neuroscience. PMID 31501572 DOI: 10.1038/S41593-019-0479-Z  0.315
2019 von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, et al. Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. The Journal of Experimental Medicine. PMID 31126966 DOI: 10.1084/Jem.20181762  0.326
2019 Segal J, Mülleder M, Krüger A, Adler T, Scholze-Wittler M, Becker L, Calzada-Wack J, Garrett L, Hölter SM, Rathkolb B, Rozman J, Racz I, Fischer R, Busch DH, Neff F, ... ... Wurst W, et al. Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency. Journal of Inherited Metabolic Disease. PMID 31111503 DOI: 10.1002/Jimd.12105  0.336
2019 van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, ... ... Wurst W, et al. A protein quality control pathway regulated by linear ubiquitination. The Embo Journal. PMID 30886048 DOI: 10.15252/Embj.2018100730  0.301
2018 Di Giaimo R, Durovic T, Barquin P, Kociaj A, Lepko T, Aschenbroich S, Breunig CT, Irmler M, Cernilogar FM, Schotta G, Barbosa JS, Trümbach D, Baumgart EV, Neuner AM, Beckers J, ... Wurst W, et al. The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis. Cell Reports. 25: 3241-3251.e5. PMID 30566853 DOI: 10.1016/J.Celrep.2018.11.055  0.328
2018 Jensen LR, Garrett L, Hölter SM, Rathkolb B, Rácz I, Adler T, Prehn C, Hans W, Rozman J, Becker L, Aguilar-Pimentel JA, Puk O, Moreth K, Dopatka M, Walther DJ, ... ... Wurst W, et al. A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 30557699 DOI: 10.1016/J.Bbadis.2018.12.011  0.363
2018 Heermann T, Garrett L, Wurst W, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Graw J, Hölter SM. Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice. Molecular Neurobiology. PMID 30291584 DOI: 10.1007/S12035-018-1365-5  0.358
2018 Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. PMID 30197237 DOI: 10.1016/J.Neuron.2018.08.017  0.345
2018 Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular Neurodegeneration. 13: 49. PMID 30185230 DOI: 10.1186/S13024-018-0280-6  0.304
2018 Weber A, Schwarz SC, Tost J, Trümbach D, Winter P, Busato F, Tacik P, Windhorst AC, Fagny M, Arzberger T, McLean C, van Swieten JC, Schwarz J, Vogt Weisenhorn D, Wurst W, et al. Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. Nature Communications. 9: 2929. PMID 30050033 DOI: 10.1038/S41467-018-05325-Y  0.304
2018 Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V. TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific Reports. 8: 8097. PMID 29802307 DOI: 10.1038/S41598-018-26397-2  0.356
2018 Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H, Hough T, ... ... Wurst W, et al. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nature Communications. 9: 288. PMID 29348434 DOI: 10.1038/S41467-017-01995-2  0.323
2017 Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, ... ... Wurst W, et al. Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. PMID 29290465 DOI: 10.1016/J.Cell.2017.11.048  0.318
2017 Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, ... ... Wurst W, et al. Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29079688 DOI: 10.1523/Jneurosci.3487-16.2017  0.321
2017 Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, ... ... Wurst W, et al. Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic. Behavioural Brain Research. PMID 28966146 DOI: 10.1016/J.Bbr.2017.09.048  0.325
2017 Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, ... ... Wurst W, et al. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Molecular Psychiatry. PMID 28696432 DOI: 10.1038/Mp.2017.133  0.327
2017 Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, ... ... Wurst W, et al. Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice. Molecular Neurobiology. PMID 28695538 DOI: 10.1007/S12035-017-0659-3  0.354
2017 Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, ... ... Wurst W, et al. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nature Genetics. PMID 28650483 DOI: 10.1038/Ng.3901  0.365
2017 Salminen AV, Garrett L, Schormair B, Rozman J, Giesert F, Niedermeier KM, Becker L, Rathkolb B, Rácz I, Klingenspor M, Klopstock T, Wolf E, Zimmer A, Gailus-Durner V, ... ... Wurst W, et al. Meis1 effects on motor phenotypes and the sensorimotor system in mice. Disease Models & Mechanisms. PMID 28645892 DOI: 10.1242/Dmm.030080  0.384
2017 Schriever SC, Zimprich A, Pfuhlmann K, Baumann P, Giesert F, Klaus V, Kabra DG, Hafen U, Romanov A, Tschöp MH, Wurst W, Conrad M, Hölter SM, Vogt Weisenhorn D, Pfluger PT. Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. Neuroscience. PMID 28627418 DOI: 10.1016/J.Neuroscience.2017.05.050  0.353
2017 Giesert F, Glasl L, Zimprich A, Ernst L, Piccoli G, Stautner C, Zerle J, Hölter SM, Vogt Weisenhorn DM, Wurst W. The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse. Neurobiology of Disease. 105: 179-193. PMID 28576705 DOI: 10.1016/J.Nbd.2017.05.013  0.308
2017 Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The Embo Journal. PMID 28559417 DOI: 10.15252/Embj.201796516  0.318
2017 Biagosch C, Ediga RD, Hensler SV, Faerberboeck M, Kuehn R, Wurst W, Meitinger T, Kölker S, Sauer S, Prokisch H. Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism. Biochimica Et Biophysica Acta. 1863: 2220-2228. PMID 28545977 DOI: 10.1016/J.Bbadis.2017.05.018  0.33
2017 Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, et al. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. Embo Reports. PMID 28483841 DOI: 10.15252/Embr.201743922  0.381
2017 Zimprich A, Östereicher MA, Becker L, Dirscherl P, Ernst L, Fuchs H, Gailus-Durner V, Garrett L, Giesert F, Glasl L, Hummel A, Rozman J, de Angelis MH, Vogt-Weisenhorn D, Wurst W, et al. Analysis of Locomotor Behavior in the German Mouse Clinic. Journal of Neuroscience Methods. PMID 28483715 DOI: 10.1016/J.Jneumeth.2017.05.005  0.305
2017 Schludi MH, Becker L, Garrett L, Gendron TF, Zhou Q, Schreiber F, Popper B, Dimou L, Strom TM, Winkelmann J, von Thaden A, Rentzsch K, May S, Michaelsen M, Schwenk BM, ... ... Wurst W, et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathologica. PMID 28409281 DOI: 10.1007/S00401-017-1711-0  0.331
2017 Wefers B, Bashir S, Rossius J, Wurst W, Kühn R. Gene editing in mouse zygotes using the CRISPR/Cas9 system. Methods (San Diego, Calif.). 121: 55-67. PMID 28263886 DOI: 10.1016/J.Ymeth.2017.02.008  0.326
2017 Dalke C, Kunze S, Rößler U, Neff F, Greiter M, Gomolka M, Hornhardt S, Garrett L, Unger K, Rosemann M, Azimzadeh O, Wurst W, Zitzelsberger H, Hölter S, Tapio S, et al. Lifetime Study in mice: radiation-induced cataract Acta Ophthalmologica. 95. DOI: 10.1111/J.1755-3768.2017.03681  0.319
2016 Graveline R, Marcinkiewicz K, Choi S, Paquet M, Wurst W, Floss T, David G. The chromatin associated Phf12 protein maintains nucleolar integrity and prevents premature cellular senescence. Molecular and Cellular Biology. PMID 27956701 DOI: 10.1128/Mcb.00522-16  0.34
2016 Deng T, Postnikov Y, Zhang S, Garrett L, Becker L, Rácz I, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Bustin M. Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation. Nucleic Acids Research. PMID 27923998 DOI: 10.1093/Nar/Gkw1222  0.327
2016 Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, Hölter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, et al. Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms. Molecular Neurobiology. PMID 27914009 DOI: 10.1007/S12035-016-0300-X  0.379
2016 Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM. Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signalling. PMID 27858314 DOI: 10.1007/S11302-016-9546-Z  0.397
2016 Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, ... ... Wurst W, et al. The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda, Md.). PMID 27815347 DOI: 10.1534/G3.116.033670  0.34
2016 Wittmann A, Grimm MO, Scherthan H, Horsch M, Beckers J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Ford SJ, Burton NC, Razansky D, Trümbach D, Aichler M, Walch AK, Calzada-Wack J, ... ... Wurst W, et al. Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice. Plos One. 11: e0164298. PMID 27788151 DOI: 10.1371/Journal.Pone.0164298  0.34
2016 Weber T, Namikawa K, Winter B, Müller-Brown K, Kühn R, Wurst W, Köster RW. Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons. Development (Cambridge, England). 143: 4279-4287. PMID 27729409 DOI: 10.1242/Dev.122721  0.303
2016 Sabrautzki S, Sandholzer MA, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso IL, Vernaleken A, Garrett L, Baron K, Yildirim AO, Rozman J, Rathkolb B, Gau C, Hans W, Hoelter SM, ... ... Wurst W, et al. Viable Ednra (Y129F) mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 27671791 DOI: 10.1007/S00335-016-9664-5  0.372
2016 Schick JA, Seisenberger C, Beig J, Bürger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W. CRISPR-Cas9 enables conditional mutagenesis of challenging loci. Scientific Reports. 6: 32326. PMID 27580957 DOI: 10.1038/Srep32326  0.345
2016 Kuperman Y, Weiss M, Dine J, Staikin K, Golani O, Ramot A, Nahum T, Kühne C, Shemesh Y, Wurst W, Harmelin A, Deussing JM, Eder M, Chen A. CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell Metabolism. PMID 27211900 DOI: 10.1016/J.Cmet.2016.04.017  0.341
2016 Vogt Weisenhorn DM, Giesert F, Wurst W. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of Neurochemistry. 139: 8-26. PMID 27206718 DOI: 10.1111/Jnc.13670  0.301
2016 Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, D'Herouel AF, Dong X, Weindl D, Stautner C, Nonnenmacher Y, Michelucci A, Popp O, Giesert F, Schildknecht S, Krämer L, ... ... Wurst W, et al. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiology of Disease. PMID 26836693 DOI: 10.1016/J.Nbd.2016.01.019  0.337
2016 Klafke R, Prem Anand AA, Wurst W, Prakash N, Wizenmann A. Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development. Development (Cambridge, England). 143: 691-702. PMID 26755703 DOI: 10.1242/Dev.126748  0.401
2016 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G. The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 5. PMID 26745185 DOI: 10.7554/Elife.09584  0.408
2016 Wefers B, Brandl C, Ortiz O, Wurst W, Kühn R. Genome Editing in Mice Using TALE Nucleases. Methods in Molecular Biology (Clifton, N.J.). 1338: 229-43. PMID 26443225 DOI: 10.1007/978-1-4939-2932-0_17  0.347
2016 Kaloff C, Anastassiadis K, Ayadi A, Baldock R, Beig J, Birling M, Bradley A, Brown S, Bürger A, Bushell W, Chiani F, Collins F, Doe B, Eppig J, Finnell R, ... ... Wurst W, et al. Genome wide conditional mouse knockout resources Drug Discovery Today: Disease Models. 20: 3-12. DOI: 10.1016/J.Ddmod.2017.08.002  0.381
2015 Hölter SM, Einicke J, Sperling B, Zimprich A, Garrett L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wurst W. Tests for Anxiety-Related Behavior in Mice. Current Protocols in Mouse Biology. 5: 291-309. PMID 26629773 DOI: 10.1002/9780470942390.Mo150010  0.324
2015 Garrett L, Zhang J, Zimprich A, Niedermeier KM, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Vogt Weisenhorn D, Wurst W, Hölter SM. Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors. Frontiers in Behavioral Neuroscience. 9: 302. PMID 26617501 DOI: 10.3389/Fnbeh.2015.00302  0.321
2015 Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, ... Wurst W, et al. Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13385-401. PMID 26424886 DOI: 10.1523/Jneurosci.1722-15.2015  0.584
2015 Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, Deussing JM. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. Plos One. 10: e0136768. PMID 26352593 DOI: 10.1371/Journal.Pone.0136768  0.324
2015 Rosen B, Schick J, Wurst W. Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 26: 456-66. PMID 26340938 DOI: 10.1007/S00335-015-9598-3  0.362
2015 Martinez-Ferre A, Lloret-Quesada C, Prakash N, Wurst W, Rubenstein JL, Martinez S. Fgf15 regulates thalamic development by controlling the expression of proneural genes. Brain Structure & Function. PMID 26311466 DOI: 10.1007/S00429-015-1089-5  0.375
2015 de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, ... ... Wurst W, et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nature Genetics. PMID 26214591 DOI: 10.1038/Ng.3360  0.39
2015 Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick JA. Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy. Human Gene Therapy Methods. PMID 26107288 DOI: 10.1089/Hgtb.2014.152  0.365
2015 Truong DJ, Kühner K, Kühn R, Werfel S, Engelhardt S, Wurst W, Ortiz O. Development of an intein-mediated split-Cas9 system for gene therapy. Nucleic Acids Research. PMID 26082496 DOI: 10.1093/Nar/Gkv601  0.331
2015 Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, et al. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron. 86: 1189-202. PMID 26050039 DOI: 10.1016/J.Neuron.2015.05.034  0.307
2015 Zhang J, Götz S, Vogt Weisenhorn DM, Simeone A, Wurst W, Prakash N. A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiology of Disease. 82: 32-45. PMID 26049140 DOI: 10.1016/J.Nbd.2015.05.015  0.396
2015 Wende CZ, Zoubaa S, Blak A, Echevarria D, Martinez S, Guillemot F, Wurst W, Guimera J. Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. Plos One. 10: e0127681. PMID 25993409 DOI: 10.1371/Journal.Pone.0127681  0.405
2015 Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Friedmann Angeli JP, Conrad M. Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility. The Journal of Biological Chemistry. 290: 14668-78. PMID 25922076 DOI: 10.1074/Jbc.M115.656363  0.347
2015 Brandl C, Ortiz O, Röttig B, Wefers B, Wurst W, Kühn R. Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos. Febs Open Bio. 5: 26-35. PMID 25685662 DOI: 10.1016/J.Fob.2014.11.009  0.316
2015 Song H, Lee B, Pyun D, Guimera J, Son Y, Yoon J, Baek K, Wurst W, Jeong Y. Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Developmental Biology. 398: 280-91. PMID 25512300 DOI: 10.1016/J.Ydbio.2014.12.003  0.329
2015 Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M. The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice. The Journal of Nutritional Biochemistry. 26: 75-81. PMID 25448609 DOI: 10.1016/J.Jnutbio.2014.09.002  0.323
2015 Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M, Beckers J, Wurst W, Klingenspor M, et al. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 26: 33-42. PMID 25308000 DOI: 10.1007/S00335-014-9545-8  0.38
2015 O'Flanagan CH, Morais VA, Wurst W, De Strooper B, O'Neill C. The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes. Oncogene. 34: 1363-74. PMID 24681957 DOI: 10.1038/Onc.2014.81  0.342
2014 Becker L, Kling E, Schiller E, Zeh R, Schrewe A, Hölter SM, Mossbrugger I, Calzada-Wack J, Strecker V, Wittig I, Dumitru I, Wenz T, Bender A, Aichler M, Janik D, ... ... Wurst W, et al. MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy. Plos One. 9: e114918. PMID 25506927 DOI: 10.1371/Journal.Pone.0114918  0.357
2014 Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, et al. Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Reports. 9: 1292-305. PMID 25456129 DOI: 10.1016/J.Celrep.2014.10.044  0.309
2014 Matthes M, Preusse M, Zhang J, Schechter J, Mayer D, Lentes B, Theis F, Prakash N, Wurst W, Trümbach D. Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain. Database : the Journal of Biological Databases and Curation. 2014. PMID 25145340 DOI: 10.1093/Database/Bau083  0.349
2014 Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Hölter SM, Janas E, Moreth K, Prehn C, ... ... Wurst W, et al. Pleiotropic functions for transcription factor zscan10. Plos One. 9: e104568. PMID 25111779 DOI: 10.1371/Journal.Pone.0104568  0.35
2014 Blanco S, Dietmann S, Flores JV, Hussain S, Kutter C, Humphreys P, Lukk M, Lombard P, Treps L, Popis M, Kellner S, Hölter SM, Garrett L, Wurst W, Becker L, et al. Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. The Embo Journal. 33: 2020-39. PMID 25063673 DOI: 10.15252/Embj.201489282  0.319
2014 Meier F, Giesert F, Delic S, Faus-Kessler T, Matheus F, Simeone A, Hölter SM, Kühn R, Weisenhorn DM, Wurst W, Prakash N. FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum. Plos One. 9: e101124. PMID 24983448 DOI: 10.1371/Journal.Pone.0101124  0.373
2014 Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, et al. Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. Plos One. 9: e98072. PMID 24896637 DOI: 10.1371/Journal.Pone.0098072  0.318
2014 Zimprich A, Garrett L, Deussing JM, Wotjak CT, Fuchs H, Gailus-Durner V, de Angelis MH, Wurst W, Hölter SM. A robust and reliable non-invasive test for stress responsivity in mice. Frontiers in Behavioral Neuroscience. 8: 125. PMID 24782732 DOI: 10.3389/Fnbeh.2014.00125  0.315
2014 Pertek A, Meier F, Irmler M, Beckers J, Skylaki S, Endele M, Wurst W, Prakash N, Kühn R. Simple derivation of transgene-free iPS cells by a dual recombinase approach. Molecular Biotechnology. 56: 697-713. PMID 24677035 DOI: 10.1007/S12033-014-9748-Y  0.343
2014 Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, ... ... Wurst W, et al. Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Research. 24: 592-603. PMID 24642863 DOI: 10.1101/Gr.166751.113  0.334
2014 Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, HrabÄ› de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, ... ... Wurst W, et al. Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. The Journal of Biological Chemistry. 289: 10769-84. PMID 24515116 DOI: 10.1074/Jbc.M113.515940  0.37
2014 Wefers B, Ortiz O, Wurst W, Kühn R. Generation of targeted mouse mutants by embryo microinjection of TALENs. Methods (San Diego, Calif.). 69: 94-101. PMID 24418396 DOI: 10.1016/J.Ymeth.2014.01.002  0.329
2014 Tripathi PP, Di Giovannantonio LG, Sanguinetti E, Acampora D, Allegra M, Caleo M, Wurst W, Simeone A, Bozzi Y. Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility. Neuroscience. 261: 173-83. PMID 24384227 DOI: 10.1016/J.Neuroscience.2013.12.045  0.397
2014 Di Giovannantonio LG, Di Salvio M, Omodei D, Prakash N, Wurst W, Pierani A, Acampora D, Simeone A. Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development (Cambridge, England). 141: 377-88. PMID 24335253 DOI: 10.1242/Dev.102954  0.314
2014 Wurst W, Prakash N. Wnt1-regulated genetic networks in midbrain dopaminergic neuron development. Journal of Molecular Cell Biology. 6: 34-41. PMID 24326514 DOI: 10.1093/Jmcb/Mjt046  0.344
2013 Kim J, Badaloni A, Willert T, Zimber-Strobl U, Kühn R, Wurst W, Kieslinger M. An RNAi-based approach to down-regulate a gene family in vivo. Plos One. 8: e80312. PMID 24265806 DOI: 10.1371/Journal.Pone.0080312  0.393
2013 Wefers B, Panda SK, Ortiz O, Brandl C, Hensler S, Hansen J, Wurst W, Kühn R. Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nature Protocols. 8: 2355-79. PMID 24177293 DOI: 10.1038/Nprot.2013.142  0.394
2013 Sun M, Hölter SM, Stepan J, Garrett L, Genius J, Kremmer E, Hrabě de Angelis M, Wurst W, Lie DC, Bally-Cuif L, Eder M, Rujescu D, Graw J. Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 24: 333-48. PMID 24096375 DOI: 10.1007/S00335-013-9478-7  0.377
2013 Häbig K, Gellhaar S, Heim B, Djuric V, Giesert F, Wurst W, Walter C, Hentrich T, Riess O, Bonin M. LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4. Biochimica Et Biophysica Acta. 1832: 2352-67. PMID 24075941 DOI: 10.1016/J.Bbadis.2013.09.009  0.36
2013 Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R. Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 195: 703-13. PMID 23979585 DOI: 10.1534/Genetics.113.156570  0.378
2013 Simon MM, Greenaway S, White JK, Fuchs H, Gailus-Durner V, Wells S, Sorg T, Wong K, Bedu E, Cartwright EJ, Dacquin R, Djebali S, Estabel J, Graw J, Ingham NJ, ... ... Wurst W, et al. A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biology. 14: R82. PMID 23902802 DOI: 10.1186/Gb-2013-14-7-R82  0.301
2013 Hock S, Ng YK, Hasenauer J, Wittmann D, Lutter D, Trümbach D, Wurst W, Prakash N, Theis FJ. Sharpening of expression domains induced by transcription and microRNA regulation within a spatio-temporal model of mid-hindbrain boundary formation. Bmc Systems Biology. 7: 48. PMID 23799959 DOI: 10.1186/1752-0509-7-48  0.323
2013 Giesert F, Hofmann A, Bürger A, Zerle J, Kloos K, Hafen U, Ernst L, Zhang J, Vogt-Weisenhorn DM, Wurst W. Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice. Plos One. 8: e63778. PMID 23675505 DOI: 10.1371/Journal.Pone.0063778  0.379
2013 Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L, Bohla A, Hölter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T, Adamski J, ... ... Wurst W, et al. High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. The Journal of Biological Chemistry. 288: 16690-703. PMID 23620591 DOI: 10.1074/Jbc.M113.463315  0.351
2013 Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, ... ... Wurst W, et al. Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity. 38: 655-68. PMID 23583643 DOI: 10.1016/J.Immuni.2012.12.004  0.337
2013 Ortiz O, Wurst W, Kühn R. Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice. Genesis (New York, N.Y. : 2000). 51: 448-55. PMID 23441035 DOI: 10.1002/Dvg.22386  0.351
2013 Wefers B, Meyer M, Ortiz O, Hrabé de Angelis M, Hansen J, Wurst W, Kühn R. Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proceedings of the National Academy of Sciences of the United States of America. 110: 3782-7. PMID 23426636 DOI: 10.1073/Pnas.1218721110  0.352
2013 Merkl C, Saalfrank A, Riesen N, Kühn R, Pertek A, Eser S, Hardt MS, Kind A, Saur D, Wurst W, Iglesias A, Schnieke A. Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. Plos One. 8: e55170. PMID 23383095 DOI: 10.1371/Journal.Pone.0055170  0.315
2013 Thiele F, Cohrs CM, Przemeck GK, Wurst W, Fuchs H, Hrabé de Angelis M. In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system. Journal of Bone and Mineral Metabolism. 31: 293-303. PMID 23371561 DOI: 10.1007/S00774-012-0421-X  0.332
2013 Di Giovannantonio LG, Di Salvio M, Acampora D, Prakash N, Wurst W, Simeone A. Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability. Developmental Biology. 373: 176-83. PMID 23117062 DOI: 10.1016/J.Ydbio.2012.10.022  0.332
2013 Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M. Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo. The Pharmacogenomics Journal. 13: 80-93. PMID 21969101 DOI: 10.1038/Tpj.2011.43  0.338
2012 Wefers B, Meyer M, Hensler S, Panda S, Ortiz O, Wurst W, Kühn R. Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases. Current Protocols in Mouse Biology. 2: 347-64. PMID 26069019 DOI: 10.1002/9780470942390.Mo120177  0.344
2012 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N. A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13292-308. PMID 22993445 DOI: 10.1523/Jneurosci.2124-12.2012  0.307
2012 Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, ... ... Wurst W, et al. The mammalian gene function resource: the International Knockout Mouse Consortium. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 580-6. PMID 22968824 DOI: 10.1007/S00335-012-9422-2  0.366
2012 Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, ... ... Wurst W, et al. Innovations in phenotyping of mouse models in the German Mouse Clinic. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 611-22. PMID 22926221 DOI: 10.1007/S00335-012-9415-1  0.301
2012 Kühne C, Puk O, Graw J, Angelis MHd, Schütz G, Wurst W, Deussing JM. Visualizing Corticotropin-Releasing Hormone Receptor Type 1 Expression and Neuronal Connectivities in the Mouse Using a Novel Multifunctional Allele The Journal of Comparative Neurology. 520: 3150-3180. PMID 22886732 DOI: 10.1002/Cne.23082  0.38
2012 Waltereit R, Leimer U, von Bohlen Und Halbach O, Panke J, Hölter SM, Garrett L, Wittig K, Schneider M, Schmitt C, Calzada-Wack J, Neff F, Becker L, Prehn C, Kutscherjawy S, Endris V, ... ... Wurst W, et al. Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4418-28. PMID 22820399 DOI: 10.1096/Fj.11-202317  0.383
2012 Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Hölter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, et al. Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines. European Journal of Oral Sciences. 120: 269-77. PMID 22813216 DOI: 10.1111/J.1600-0722.2012.00966.X  0.302
2012 Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, ... ... Wurst W, et al. Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. Plos One. 7: e38310. PMID 22701626 DOI: 10.1371/Journal.Pone.0038310  0.38
2012 Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Müller MB, Schmidt MV. Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. The European Journal of Neuroscience. 36: 2360-7. PMID 22672268 DOI: 10.1111/J.1460-9568.2012.08148.X  0.332
2012 Graf C, Kuehne C, Panhuysen M, Puetz B, Weber P, Holsboer F, Wurst W, Deussing JM. Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells. Molecular and Cellular Endocrinology. 362: 29-38. PMID 22659651 DOI: 10.1016/J.Mce.2012.05.007  0.372
2012 Breu J, Touma C, Hölter SM, Knapman A, Wurst W, Deussing JM. Urocortin 2 modulates aspects of social behaviour in mice. Behavioural Brain Research. 233: 331-6. PMID 22640813 DOI: 10.1016/J.Bbr.2012.05.031  0.326
2012 Wefers B, Hitz C, Hölter SM, Trümbach D, Hansen J, Weber P, Pütz B, Deussing JM, de Angelis MH, Roenneberg T, Zheng F, Alzheimer C, Silva A, Wurst W, Kühn R. MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults. Plos One. 7: e35035. PMID 22529971 DOI: 10.1371/Journal.Pone.0035035  0.381
2012 Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, ... ... Wurst W, et al. Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. Plos Genetics. 8: e1002568. PMID 22438821 DOI: 10.1371/Journal.Pgen.1002568  0.357
2012 Dedic N, Touma C, Romanowski CP, Schieven M, Kühne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M, Deussing JM. Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice. Cellular and Molecular Neurobiology. 32: 815-28. PMID 22198557 DOI: 10.1007/S10571-011-9784-0  0.344
2012 Thoeringer CK, Henes K, Eder M, Dahlhoff M, Wurst W, Holsboer F, Deussing JM, Moosmang S, Wotjak CT. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 787-96. PMID 22030710 DOI: 10.1038/Npp.2011.256  0.301
2012 O'Flanagan CH, Morais V, Kloos K, Wurst W, Strooper Bd, O'Neill C. Abstract 1117: Investigating the role of PTEN-induced kinase 1 in cancer development and pathogenesis Cancer Research. 72: 1117-1117. DOI: 10.1158/1538-7445.Am2012-1117  0.313
2012 Dedic N, Ableitner M, Touma C, Wang XD, Kühne C, Schmidt MV, Wurst W, Holsboer F, Refojo D, Deussing JM. P.4.013 Assessing CRH-mediated anxiogenic and anxiolytic effects using region-and neurotransmitter-specific CRH overexpressing mice European Neuropsychopharmacology. 22. DOI: 10.1016/S0924-977X(12)70099-8  0.32
2011 Wefers B, Wurst W, Kühn R. Design and Generation of Gene-Targeting Vectors. Current Protocols in Mouse Biology. 1: 199-211. PMID 26068993 DOI: 10.1002/9780470942390.Mo100179  0.34
2011 Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV. Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13625-34. PMID 21940453 DOI: 10.1523/Jneurosci.2259-11.2011  0.308
2011 Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, ... ... Wurst W, et al. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metabolism. 14: 208-18. PMID 21803291 DOI: 10.1016/J.Cmet.2011.06.007  0.315
2011 Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt-Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice. Brain : a Journal of Neurology. 134: 2044-56. PMID 21672962 DOI: 10.1093/Brain/Awr133  0.332
2011 de Andrés-Aguayo L, Varas F, Kallin EM, Infante JF, Wurst W, Floss T, Graf T. Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice. Blood. 118: 554-64. PMID 21613258 DOI: 10.1182/Blood-2010-12-322081  0.404
2011 Augustin R, Lichtenthaler SF, Greeff M, Hansen J, Wurst W, Trümbach D. Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays. International Journal of Alzheimer's Disease. 2011: 154325. PMID 21559189 DOI: 10.4061/2011/154325  0.305
2011 Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool Journal of Neuroscience. 31: 2225-2237. PMID 21307259 DOI: 10.1523/Jneurosci.3730-10.2011  0.31
2011 Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiology of Disease. 42: 300-10. PMID 21296667 DOI: 10.1016/J.Nbd.2011.01.020  0.304
2011 Fischer T, Faus-Kessler T, Welzl G, Simeone A, Wurst W, Prakash N. Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis. Developmental Biology. 350: 496-510. PMID 21172336 DOI: 10.1016/J.Ydbio.2010.12.017  0.398
2011 Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH. Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development. Molecular and Cellular Neurosciences. 46: 419-31. PMID 21122816 DOI: 10.1016/J.Mcn.2010.11.005  0.338
2011 Friedel RH, Wurst W, Wefers B, Kühn R. Generating conditional knockout mice Methods in Molecular Biology (Clifton, N.J.). 693: 205-231. PMID 21080282 DOI: 10.1007/978-1-60761-974-1_12  0.411
2011 von Wolff G, Avrabos C, Stepan J, Wurst W, Deussing JM, Holsboer F, Eder M. Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation. Journal of Psychiatric Research. 45: 256-61. PMID 20619419 DOI: 10.1016/J.Jpsychires.2010.06.007  0.341
2010 Zhang J, Giesert F, Kloos K, Vogt Weisenhorn DM, Aigner L, Wurst W, Couillard-Despres S. A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons. Bmc Neuroscience. 11: 158. PMID 21194452 DOI: 10.1186/1471-2202-11-158  0.348
2010 Kleinhammer A, Wurst W, Kühn R. Constitutive and conditional RNAi transgenesis in mice. Methods (San Diego, Calif.). 53: 430-6. PMID 21184828 DOI: 10.1016/J.Ymeth.2010.12.015  0.393
2010 Trümbach D, Graf C, Pütz B, Kühne C, Panhuysen M, Weber P, Holsboer F, Wurst W, Welzl G, Deussing JM. Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models. Bmc Systems Biology. 4: 159. PMID 21092110 DOI: 10.1186/1752-0509-4-159  0.335
2010 Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein. Bmc Genomics. 11: 546. PMID 20932279 DOI: 10.1186/1471-2164-11-546  0.34
2010 Kleinhammer A, Deussing J, Wurst W, Kühn R. Conditional RNAi in mice. Methods (San Diego, Calif.). 53: 142-50. PMID 20705138 DOI: 10.1016/J.Ymeth.2010.08.003  0.393
2010 Kleinhammer A, Wurst W, Kühn R. Gene knockdown in the mouse through RNAi. Methods in Enzymology. 477: 387-414. PMID 20699152 DOI: 10.1016/S0076-6879(10)77020-8  0.392
2010 Meyer M, de Angelis MH, Wurst W, Kühn R. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proceedings of the National Academy of Sciences of the United States of America. 107: 15022-6. PMID 20686113 DOI: 10.1073/Pnas.1009424107  0.335
2010 Kinzel D, Boldt K, Davis EE, Burtscher I, Trümbach D, Diplas B, Attié-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Developmental Cell. 19: 66-77. PMID 20643351 DOI: 10.1016/J.Devcel.2010.06.005  0.311
2010 Wurst W, de Angelis MH. Systematic phenotyping of mouse mutants. Nature Biotechnology. 28: 684-5. PMID 20622838 DOI: 10.1038/Nbt0710-684  0.357
2010 Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, ... ... Wurst W, et al. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9103-16. PMID 20610744 DOI: 10.1523/Jneurosci.1049-10.2010  0.372
2010 Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, ... ... Wurst W, et al. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. The Embo Journal. 29: 2421-32. PMID 20551902 DOI: 10.1038/Emboj.2010.120  0.339
2010 Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kühn R, Wurst W, Lickert H, Rossant J. Phenotypic annotation of the mouse X chromosome. Genome Research. 20: 1154-64. PMID 20548051 DOI: 10.1101/Gr.105106.110  0.332
2010 Hackl C, Papazoglou A, Ganser C, Klein A, Prakash N, Wurst W, Nikkhah G. Ectopic dopaminergic progenitor cells from En1(+/Otx2lacZ) transgenic mice survive and functionally reinnervate the striatum following transplantation in a rat model of Parkinson's disease. Cell Transplantation. 19: 1085-101. PMID 20447348 DOI: 10.3727/096368910X505468  0.356
2010 Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M. Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep. 33: 427-36. PMID 20394311 DOI: 10.1093/Sleep/33.4.427  0.315
2010 Jawerka M, Colak D, Dimou L, Spiller C, Lagger S, Montgomery RL, Olson EN, Wurst W, Gttlicher M, Götz M. The specific role of histone deacetylase 2 in adult neurogenesis Neuron Glia Biology. 6: 93-107. PMID 20388229 DOI: 10.1017/S1740925X10000049  0.359
2010 Aron L, Klein P, Pham TT, Kramer ER, Wurst W, Klein R. Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. Plos Biology. 8: e1000349. PMID 20386724 DOI: 10.1371/Journal.Pbio.1000349  0.36
2010 Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T. Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. Nucleic Acids Research. 38: e106. PMID 20139417 DOI: 10.1093/Nar/Gkq044  0.354
2010 Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, ... ... Wurst W, et al. DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes, Brain, and Behavior. 9: 305-17. PMID 20039949 DOI: 10.1111/J.1601-183X.2009.00559.X  0.386
2010 Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, ... ... Wurst W, et al. Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 13-27. PMID 20033184 DOI: 10.1007/S00335-009-9235-0  0.388
2010 Stuebner S, Faus-Kessler T, Fischer T, Wurst W, Prakash N. Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 246-60. PMID 19842188 DOI: 10.1002/Dvdy.22127  0.355
2010 Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E. Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 211-21. PMID 19795519 DOI: 10.1002/Dvdy.22094  0.593
2010 Soehn AS, Pham TT, Schaeferhoff K, Floss T, Weisenhorn DM, Wurst W, Bonin M, Riess O. Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development. Genesis (New York, N.Y. : 2000). 47: 697-707. PMID 19621438 DOI: 10.1002/Dvg.20553  0.396
2010 Beckers J, Wurst W, de Angelis MH. Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling. Nature Reviews. Genetics. 10: 371-80. PMID 19434078 DOI: 10.1038/Nrg2578  0.342
2009 Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W, Scorrano L, De Strooper B. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. Embo Molecular Medicine. 1: 99-111. PMID 20049710 DOI: 10.1002/Emmm.200900006  0.304
2009 Wittmann DM, Blöchl F, Trümbach D, Wurst W, Prakash N, Theis FJ. Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary. Plos Computational Biology. 5: e1000569. PMID 19936059 DOI: 10.1371/Journal.Pcbi.1000569  0.318
2009 Grzmil P, Konietzko J, Boehm D, Hölter SM, Hoelter SM, Aguilar-Pimentel A, Aguilar A, Javaheri A, Kalaydjiev S, Adler T, Bolle I, Adham I, Dixkens C, Wolf S, Fuchs H, ... ... Wurst W, et al. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. Cytogenetic and Genome Research. 125: 186-200. PMID 19738379 DOI: 10.1159/000230003  0.389
2009 Wirth EK, Roth S, Blechschmidt C, Hölter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs H, Wurst W, Naumann T, Bräuer A, de Angelis MH, Köhrle J, et al. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9439-49. PMID 19641107 DOI: 10.1523/Jneurosci.6055-08.2009  0.344
2009 Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (Cambridge, England). 136: 2545-55. PMID 19592574 DOI: 10.1242/Dev.031781  0.333
2009 Rubio-Aliaga I, Przemeck GK, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J, Schrewe A, Wagner S, Hoelter SM, Becker L, Klopstock T, Wurst W, et al. Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. Plos One. 4: e6054. PMID 19562077 DOI: 10.1371/Journal.Pone.0006054  0.34
2009 Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. The Journal of Biological Chemistry. 284: 22938-51. PMID 19546216 DOI: 10.1074/Jbc.M109.035774  0.305
2009 Liebl C, Panhuysen M, Pütz B, Trümbach D, Wurst W, Deussing JM, Müller MB, Schmidt MV. Gene expression profiling following maternal deprivation: involvement of the brain Renin-Angiotensin system. Frontiers in Molecular Neuroscience. 2: 1. PMID 19506703 DOI: 10.3389/Neuro.02.001.2009  0.34
2009 Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, ... ... Wurst W, et al. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 137: 961-71. PMID 19490899 DOI: 10.1016/J.Cell.2009.03.041  0.341
2009 Silberstein S, Vogl AM, Refojo D, Senin SA, Wurst W, Holsboer F, Deussing JM, Arzt E. Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions. Neuroscience. 159: 610-7. PMID 19361479 DOI: 10.1016/J.Neuroscience.2009.01.014  0.333
2009 Perez-Balaguer A, Puelles E, Wurst W, Martinez S. Shh dependent and independent maintenance of basal midbrain Mechanisms of Development. 126: 301-313. PMID 19298856 DOI: 10.1016/J.Mod.2009.03.001  0.352
2009 Waak J, Weber SS, Waldenmaier A, Görner K, Alunni‐Fabbroni M, Schell H, Vogt‐Weisenhorn D, Pham T, Reumers V, Baekelandt V, Wurst W, Kahle PJ. Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1 The Faseb Journal. 23: 2478-2489. PMID 19276172 DOI: 10.1096/Fj.08-125153  0.303
2009 Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, ... ... Wurst W, et al. Systemic first-line phenotyping. Methods in Molecular Biology (Clifton, N.J.). 530: 463-509. PMID 19266331 DOI: 10.1007/978-1-59745-471-1_25  0.331
2009 Silberstein S, Vogl AM, Bonfiglio JJ, Wurst W, Holsboer F, Arzt E, Deussing JM, Refojo D. Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models. Annals of the New York Academy of Sciences. 1153: 120-30. PMID 19236335 DOI: 10.1111/J.1749-6632.2008.03967.X  0.33
2009 Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, ... ... Wurst W, et al. The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Current Pharmaceutical Biotechnology. 10: 236-43. PMID 19199957 DOI: 10.2174/138920109787315051  0.339
2009 Prinzen C, Trümbach D, Wurst W, Endres K, Postina R, Fahrenholz F. Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice. Bmc Genomics. 10: 66. PMID 19196476 DOI: 10.1186/1471-2164-10-66  0.313
2009 Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T. Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochimica Et Biophysica Acta. 1787: 371-6. PMID 19111522 DOI: 10.1016/J.Bbabio.2008.12.001  0.329
2009 Kala K, Haugas M, Lilleväli K, Guimera J, Wurst W, Salminen M, Partanen J. Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons. Development (Cambridge, England). 136: 253-62. PMID 19088086 DOI: 10.1242/Dev.029900  0.367
2009 Kamprath K, Plendl W, Marsicano G, Deussing JM, Wurst W, Lutz B, Wotjak CT. Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling Genes, Brain and Behavior. 8: 203-211. PMID 19077175 DOI: 10.1111/J.1601-183X.2008.00463.X  0.351
2009 Risbrough VB, Geyer MA, Hauger RL, Coste S, Stenzel-Poore M, Wurst W, Holsboer F. CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1494-503. PMID 19020499 DOI: 10.1038/Npp.2008.205  0.335
2009 Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing J, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. Stress-induced gene expression in the paraventricular nucleus of hypothalamus in the mouse strains DBA/2J and C57BL/6J – potential signalling pathways involved Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240237  0.331
2009 Kala K, Haugas M, Lilleväli K, Guimera J, Wurst W, Salminen M, Partanen J. 12-P003 Gata2 is a postmitotic selector gene for GABAergic neurons in the midbrain Mechanisms of Development. 126. DOI: 10.1016/J.Mod.2009.06.457  0.308
2008 Söker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hölter SM, Horsch M, Kallnik M, Kling E, Moerth C, Schrewe A, Stigloher C, ... ... Wurst W, et al. Pleiotropic effects in Eya3 knockout mice. Bmc Developmental Biology. 8: 118. PMID 19102749 DOI: 10.1186/1471-213X-8-118  0.346
2008 Di Benedetto B, Benedetto BD, Wefers B, Wurst W, Kühn R. Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference. Molecular Biotechnology. 41: 263-9. PMID 19052925 DOI: 10.1007/S12033-008-9125-9  0.34
2008 Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. Plos One. 3: e3517. PMID 18953410 DOI: 10.1371/Journal.Pone.0003517  0.584
2008 Böhm J, Buck A, Borozdin W, Mannan AU, Matysiak-Scholze U, Adham I, Schulz-Schaeffer W, Floss T, Wurst W, Kohlhase J, Barrionuevo F. Sall1, sall2, and sall4 are required for neural tube closure in mice. The American Journal of Pathology. 173: 1455-63. PMID 18818376 DOI: 10.2353/Ajpath.2008.071039  0.388
2008 Tripathi PP, Giovannantonio LGD, Viegi A, Wurst W, Simeone A, Bozzi Y. Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice The Journal of Neuroscience. 28: 9271-9276. PMID 18784307 DOI: 10.1523/Jneurosci.2208-08.2008  0.34
2008 Uez N, Lickert H, Kohlhase J, de Angelis MH, Kühn R, Wurst W, Floss T. Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis (New York, N.Y. : 2000). 46: 463-77. PMID 18781635 DOI: 10.1002/Dvg.20421  0.311
2008 Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M. Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death Cell Metabolism. 8: 237-248. PMID 18762024 DOI: 10.1016/J.Cmet.2008.07.005  0.317
2008 Klafke R, Wurst W, Prakash N. Genetic control of rodent midbrain dopaminergic neuron development in the light of human disease. Pharmacopsychiatry. 41: S44-50. PMID 18756420 DOI: 10.1055/S-2008-1080902  0.349
2008 Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement AB, Behl C. Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience. 156: 712-21. PMID 18708129 DOI: 10.1016/J.Neuroscience.2008.07.034  0.349
2008 Kronsbein HC, Jastorff AM, Maccarrone G, Stalla G, Wurst W, Holsboer F, Turck CW, Deussing JM. CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells. Molecular and Cellular Endocrinology. 292: 1-10. PMID 18582531 DOI: 10.1016/J.Mce.2008.05.017  0.332
2008 Tsolakidou A, Trümbach D, Panhuysen M, Pütz B, Deussing J, Wurst W, Sillaber I, Holsboer F, Rein T. Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways. Molecular and Cellular Neurosciences. 38: 444-52. PMID 18524625 DOI: 10.1016/J.Mcn.2008.04.005  0.348
2008 Delic S, Streif S, Deussing JM, Weber P, Ueffing M, Hölter SM, Wurst W, Kühn R. Genetic mouse models for behavioral analysis through transgenic RNAi technology Genes, Brain and Behavior. 7: 821-830. PMID 18518923 DOI: 10.1111/J.1601-183X.2008.00412.X  0.406
2008 Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Molecular Psychiatry. 13: 1028-42. PMID 18475271 DOI: 10.1038/Mp.2008.51  0.305
2008 Schmidt S, Gawlik V, Hölter SM, Augustin R, Scheepers A, Behrens M, Wurst W, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Kluge R, Joost HG, Schürmann A. Deletion of glucose transporter GLUT8 in mice increases locomotor activity. Behavior Genetics. 38: 396-406. PMID 18461434 DOI: 10.1007/S10519-008-9208-1  0.351
2008 Di Benedetto B, Kallnik M, Weisenhorn DM, Falls WA, Wurst W, Hölter SM. Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear-potentiated startle response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 356-66. PMID 18432190 DOI: 10.1038/Npp.2008.57  0.32
2008 Ganguly K, Favor J, Neuhäuser-Klaus A, Sandulache R, Puk O, Beckers J, Horsch M, Schädler S, Vogt Weisenhorn D, Wurst W, Graw J. Novel allele of crybb2 in the mouse and its expression in the brain. Investigative Ophthalmology & Visual Science. 49: 1533-41. PMID 18385073 DOI: 10.1167/Iovs.07-0788  0.318
2008 Steuber-Buchberger P, Wurst W, Kühn R. Simultaneous Cre-mediated conditional knockdown of two genes in mice. Genesis (New York, N.Y. : 2000). 46: 144-51. PMID 18327788 DOI: 10.1002/Dvg.20376  0.361
2008 Bender A, Beckers J, Schneider I, Hölter SM, Haack T, Ruthsatz T, Vogt-Weisenhorn DM, Becker L, Genius J, Rujescu D, Irmler M, Mijalski T, Mader M, Quintanilla-Martinez L, Fuchs H, ... ... Wurst W, et al. Creatine improves health and survival of mice Neurobiology of Aging. 29: 1404-1411. PMID 17416441 DOI: 10.1016/J.Neurobiolaging.2007.03.001  0.334
2008 Prakash N, Andersson E, Minina E, Klafke R, Simeone A, Arenas E, Wurst W. [ST3]: Genetic pathways controlling midbrain dopaminergic neuron development in vivo International Journal of Developmental Neuroscience. 26: 833-833. DOI: 10.1016/J.Ijdevneu.2008.09.029  0.553
2007 Friedel RH, Seisenberger C, Kaloff C, Wurst W. EUCOMM--the European conditional mouse mutagenesis program. Briefings in Functional Genomics & Proteomics. 6: 180-5. PMID 17967808 DOI: 10.1093/Bfgp/Elm022  0.362
2007 Zimmermann S, Kiefer F, Prudenziati M, Spiller C, Hansen J, Floss T, Wurst W, Minucci S, Göttlicher M. Reduced Body Size and Decreased Intestinal Tumor Rates in HDAC2-Mutant Mice Cancer Research. 67: 9047-9054. PMID 17909008 DOI: 10.1158/0008-5472.Can-07-0312  0.354
2007 Schmidt MV, Oitzl M, Steenbergen P, Lachize S, Wurst W, Müller MB, de Kloet ER, Meijer OC. Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function. Brain Research. 1174: 1-6. PMID 17854779 DOI: 10.1016/J.Brainres.2007.08.023  0.363
2007 Saarimäki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J. Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8581-92. PMID 17687036 DOI: 10.1523/Jneurosci.0192-07.2007  0.375
2007 Zhao Y, Kwan KM, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR, Westphal H. LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 104: 13182-6. PMID 17664423 DOI: 10.1073/Pnas.0705464104  0.383
2007 Prakash N, Wurst W. A Wnt signal regulates stem cell fate and differentiation in vivo. Neuro-Degenerative Diseases. 4: 333-8. PMID 17627138 DOI: 10.1159/000101891  0.366
2007 Hitz C, Wurst W, Kühn R. Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference. Nucleic Acids Research. 35: e90. PMID 17586814 DOI: 10.1093/Nar/Gkm475  0.379
2007 Fischer T, Guimera J, Wurst W, Prakash N. Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain. Neuroscience. 147: 693-711. PMID 17582687 DOI: 10.1016/J.Neuroscience.2007.04.060  0.386
2007 Tiedemann HB, Schneltzer E, Zeiser S, Rubio-Aliaga I, Wurst W, Beckers J, Przemeck GK, Hrabé de Angelis M. Cell-based simulation of dynamic expression patterns in the presomitic mesoderm. Journal of Theoretical Biology. 248: 120-9. PMID 17575987 DOI: 10.1016/J.Jtbi.2007.05.014  0.317
2007 Collins FS, Finnell RH, Rossant J, Wurst W. A new partner for the international knockout mouse consortium. Cell. 129: 235. PMID 17448981 DOI: 10.1016/J.Cell.2007.04.007  0.345
2007 Kallnik M, Elvert R, Ehrhardt N, Kissling D, Mahabir E, Welzl G, Faus-Kessler T, de Angelis MH, Wurst W, Schmidt J, Hölter SM. Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 18: 173-86. PMID 17431719 DOI: 10.1007/S00335-007-9002-Z  0.313
2007 Görner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C, Kahle PJ. Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. The Journal of Biological Chemistry. 282: 13680-91. PMID 17331951 DOI: 10.1074/Jbc.M609821200  0.305
2007 Schierloh A, Deussing J, Wurst W, Zieglgänsberger W, Rammes G. Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. Neuroscience Letters. 416: 82-6. PMID 17316992 DOI: 10.1016/J.Neulet.2007.01.047  0.319
2007 Kühn R, Streif S, Wurst W. RNA interference in mice. Handbook of Experimental Pharmacology. 149-76. PMID 17203655 DOI: 10.1007/978-3-540-35109-2_7  0.35
2007 Blak AA, Naserke T, Saarimäki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J, Wurst W. Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Developmental Biology. 303: 231-43. PMID 17150206 DOI: 10.1016/J.Ydbio.2006.11.008  0.372
2007 Benedetto BD, Hitz C, Hölter SM, Kühn R, Weisenhorn DMV, Wurst W. Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain The Journal of Comparative Neurology. 500: 542-556. PMID 17120291 DOI: 10.1002/Cne.21186  0.318
2007 Haack T, Bender A, Beckers J, Hölter S, Ruthsatz T, Vogt-Weisenhorn D, Becker L, Genius J, Rujescu D, Irmler M, Mijalski T, Mader M, Quintanilla-Martinez L, Fuchs H, Gailus-Durner V, ... ... Wurst W, et al. Creatine improves health and survival in mice Aktuelle Neurologie. 34. DOI: 10.1055/S-2007-987803  0.332
2006 Vauti F, Goller T, Beine R, Becker L, Klopstock T, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Arnold HH. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Gene. 389: 174-85. PMID 17198746 DOI: 10.1016/J.Gene.2006.11.004  0.406
2006 Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Müller MB, de Kloet ER. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. The European Journal of Neuroscience. 24: 2291-8. PMID 17042789 DOI: 10.1111/J.1460-9568.2006.05121.X  0.362
2006 Grad I, McKee TA, Ludwig SM, Hoyle GW, Ruiz P, Wurst W, Floss T, Miller CA, Picard D. The Hsp90 cochaperone p23 is essential for perinatal survival. Molecular and Cellular Biology. 26: 8976-83. PMID 17000766 DOI: 10.1128/Mcb.00734-06  0.314
2006 Beekman C, Nichane M, De Clercq S, Maetens M, Floss T, Wurst W, Bellefroid E, Marine JC. Evolutionarily conserved role of nucleostemin: Controlling proliferation of stem/progenitor cells during early vertebrate development Molecular and Cellular Biology. 26: 9291-9301. PMID 17000755 DOI: 10.1128/Mcb.01183-06  0.358
2006 Guimera J, Weisenhorn DV, Wurst W. Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus. Development. 133: 3847-3857. PMID 16968817 DOI: 10.1242/Dev.02557  0.403
2006 Nguyen NK, Keck ME, Hetzenauer A, Thoeringer CK, Wurst W, Deussing JM, Holsboer F, Müller MB, Singewald N. Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge. Psychopharmacology. 188: 374-85. PMID 16953386 DOI: 10.1007/S00213-006-0513-1  0.379
2006 Poët M, Kornak U, Schweizer M, Zdebik AA, Scheel O, Hoelter S, Wurst W, Schmitt A, Fuhrmann JC, Planells-Cases R, Mole SE, Hübner CA, Jentsch TJ. Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6. Proceedings of the National Academy of Sciences of the United States of America. 103: 13854-9. PMID 16950870 DOI: 10.1073/Pnas.0606137103  0.34
2006 Prakash N, Wurst W. Genetic networks controlling the development of midbrain dopaminergic neurons. The Journal of Physiology. 575: 403-10. PMID 16825303 DOI: 10.1113/Jphysiol.2006.113464  0.363
2006 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J. FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Developmental Biology. 297: 141-57. PMID 16782087 DOI: 10.1016/J.Ydbio.2006.05.002  0.361
2006 Mori T, Tanaka K, Buffo A, Wurst W, Kühn R, Götz M. Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis. Glia. 54: 21-34. PMID 16652340 DOI: 10.1002/Glia.20350  0.362
2006 Guimera J, Vogt Weisenhorn D, Echevarría D, Martínez S, Wurst W. Molecular characterization, structure and developmental expression of Megane bHLH factor. Gene. 377: 65-76. PMID 16644143 DOI: 10.1016/J.Gene.2006.02.026  0.343
2006 Barrantes Idel B, Montero-Pedrazuela A, Guadaño-Ferraz A, Obregon MJ, Martinez de Mena R, Gailus-Durner V, Fuchs H, Franz TJ, Kalaydjiev S, Klempt M, Hölter S, Rathkolb B, Reinhard C, Morreale de Escobar G, Bernal J, ... ... Wurst W, et al. Generation and characterization of dickkopf3 mutant mice. Molecular and Cellular Biology. 26: 2317-26. PMID 16508007 DOI: 10.1128/Mcb.26.6.2317-2326.2006  0.368
2006 De-Zolt S, Schnütgen F, Seisenberger C, Hansen J, Hollatz M, Floss T, Ruiz P, Wurst W, von Melchner H. High-throughput trapping of secretory pathway genes in mouse embryonic stem cells. Nucleic Acids Research. 34: e25. PMID 16478711 DOI: 10.1093/Nar/Gnj026  0.331
2006 Prakash N, Wurst W. Development of dopaminergic neurons in the mammalian brain. Cellular and Molecular Life Sciences : Cmls. 63: 187-206. PMID 16389456 DOI: 10.1007/S00018-005-5387-6  0.333
2006 Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (Cambridge, England). 133: 89-98. PMID 16339193 DOI: 10.1242/Dev.02181  0.592
2006 Borgkvist A, Puelles E, Carta M, Acampora D, Ang SL, Wurst W, Goiny M, Fisone G, Simeone A, Usiello A. Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice. Molecular and Cellular Neurosciences. 31: 293-302. PMID 16256364 DOI: 10.1016/J.Mcn.2005.09.018  0.388
2005 Conrad M, Moreno SG, Sinowatz F, Ursini F, Kölle S, Roveri A, Brielmeier M, Wurst W, Maiorino M, Bornkamm GW. The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Molecular and Cellular Biology. 25: 7637-44. PMID 16107710 DOI: 10.1128/Mcb.25.17.7637-7644.2005  0.335
2005 Hitz C, Vogt-Weisenhorn D, Ruiz P, Wurst W, Floss T. Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality. Genesis (New York, N.Y. : 2000). 42: 91-103. PMID 15887267 DOI: 10.1002/Gene.20128  0.378
2005 Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H. Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. Proceedings of the National Academy of Sciences of the United States of America. 102: 7221-6. PMID 15870191 DOI: 10.1073/Pnas.0502273102  0.351
2005 Refojo D, Echenique C, Müller MB, Reul JM, Deussing JM, Wurst W, Sillaber I, Paez-Pereda M, Holsboer F, Arzt E. Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proceedings of the National Academy of Sciences of the United States of America. 102: 6183-8. PMID 15833812 DOI: 10.1073/Pnas.0502070102  0.328
2005 Blak AA, Naserke T, Weisenhorn DM, Prakash N, Partanen J, Wurst W. Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 233: 1023-30. PMID 15830353 DOI: 10.1002/Dvdy.20386  0.303
2005 Deussing JM, Wurst W. Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour. Comptes Rendus Biologies. 328: 199-212. PMID 15771006 DOI: 10.1016/J.Crvi.2005.01.001  0.322
2005 Jakupoglu C, Przemeck GK, Schneider M, Moreno SG, Mayr N, Hatzopoulos AK, de Angelis MH, Wurst W, Bornkamm GW, Brielmeier M, Conrad M. Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Molecular and Cellular Biology. 25: 1980-8. PMID 15713651 DOI: 10.1128/Mcb.25.5.1980-1988.2005  0.359
2005 Trokovic R, Jukkola T, Saarimäki J, Peltopuro P, Naserke T, Weisenhorn DM, Trokovic N, Wurst W, Partanen J. Fgfr1-dependent boundary cells between developing mid- and hindbrain. Developmental Biology. 278: 428-39. PMID 15680361 DOI: 10.1016/J.Ydbio.2004.11.024  0.318
2005 Lu A, Steiner M, Engelholm M, Engelholm M, Wotjak C, Holsboer F, Wurst W, Deussing J. Site-specific overexpression of corticotropin-releasing hormone (CRH) in the mouse brain – modelling central CRH system hyperactivity Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918770  0.356
2005 Deussing J, Kühne C, Panhuysen M, Pütz B, Breu J, Paez-Pereda M, Holsboer F, Wurst W. Gene expression profiling reveals corticotropin-releasing hormone (CRH) dependent signaling pathways Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918660  0.304
2004 Chen Y, Bender RA, Brunson KL, Pomper JK, Grigoriadis DE, Wurst W, Baram TZ. Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 101: 15782-7. PMID 15496472 DOI: 10.1073/Pnas.0403975101  0.342
2004 Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Molecular and Cellular Biology. 24: 9414-23. PMID 15485910 DOI: 10.1128/Mcb.24.21.9414-9423.2004  0.317
2004 Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, ... ... Wurst W, et al. The European dimension for the mouse genome mutagenesis program. Nature Genetics. 36: 925-7. PMID 15340424 DOI: 10.1038/Ng0904-925  0.323
2004 Prakash N, Wurst W. Specification of midbrain territory. Cell and Tissue Research. 318: 5-14. PMID 15322917 DOI: 10.1007/S00441-004-0955-X  0.331
2004 Andrae J, Afink G, Zhang X, Wurst W, Nistér M. Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia Molecular and Cellular Neuroscience. 26: 308-321. PMID 15207855 DOI: 10.1016/J.Mcn.2004.02.004  0.363
2004 Kwan KM, Li AG, Wang XJ, Wurst W, Behringer RR. Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis Genesis. 39: 10-25. PMID 15124223 DOI: 10.1002/Gene.20021  0.308
2004 Panhuysen M, Weisenhorn DMV, Blanquet V, Brodski C, Heinzmann U, Beisker W, Wurst W. Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region Molecular and Cellular Neuroscience. 26: 101-111. PMID 15121182 DOI: 10.1016/J.Mcn.2004.01.011  0.393
2004 Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A. Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development. 131: 2037-2048. PMID 15105370 DOI: 10.1242/Dev.01107  0.356
2004 Bolz J, Uziel D, Mühlfriedel S, Güllmar A, Peuckert C, Zarbalis K, Wurst W, Torii M, Levitt P. Multiple roles of ephrins during the formation of thalamocortical projections: maps and more. Journal of Neurobiology. 59: 82-94. PMID 15007829 DOI: 10.1002/Neu.10346  0.305
2004 Conrad M, Brielmeier M, Wurst W, Bornkamm GW. Optimized vector for conditional gene targeting in mouse embryonic stem cells. Biotechniques. 34: 1136-8, 1140. PMID 12813877 DOI: 10.2144/03346Bm03  0.305
2003 Louvi A, Alexandre P, Métin C, Wurst W, Wassef M. The isthmic neuroepithelium is essential for cerebellar midline fusion. Development (Cambridge, England). 130: 5319-30. PMID 14507778 DOI: 10.1242/Dev.00736  0.319
2003 Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proceedings of the National Academy of Sciences of the United States of America. 100: 9918-22. PMID 12904583 DOI: 10.1073/Pnas.1633296100  0.338
2003 Schmidt MV, Schmidt M, Oitzl MS, Müller MB, Ohl F, Wurst W, Holsboer F, Levine S, De Kloet ER. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Neuroscience. 119: 589-95. PMID 12770571 DOI: 10.1016/S0306-4522(03)00097-6  0.346
2003 Chi CL, Martinez S, Wurst W, Martin GR. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development (Cambridge, England). 130: 2633-44. PMID 12736208 DOI: 10.1242/Dev.00487  0.34
2003 Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. The Embo Journal. 22: 1811-23. PMID 12682014 DOI: 10.1093/Emboj/Cdg169  0.341
2003 Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A. Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain Nature Neuroscience. 6: 453-460. PMID 12652306 DOI: 10.1038/Nn1037  0.326
2003 Corradi A, Croci L, Broccoli V, Zecchini S, Previtali S, Wurst W, Amadio S, Maggi R, Quattrini A, Consalez GG. Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice. Development (Cambridge, England). 130: 401-10. PMID 12466206 DOI: 10.1242/Dev.00215  0.363
2003 Brodski C, Weisenhorn DMV, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W. Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain–Hindbrain Organizer The Journal of Neuroscience. 23: 4199-4207. DOI: 10.1523/Jneurosci.23-10-04199.2003  0.367
2003 Amadio S, Corradi A, Croci L, Broccoli V, Zecchini S, Previtali S, Wurst W, Maggi R, Del Carro U, Quattrini A, Consalez G. Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 43 Journal of the Peripheral Nervous System. 8: 29-58. DOI: 10.1046/J.1529-8027.2003.00043.X  0.334
2002 Rantanen M, Palmén T, Pätäri A, Ahola H, Lehtonen S, Aström E, Floss T, Vauti F, Wurst W, Ruiz P, Kerjaschki D, Holthöfer H. Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions. Journal of the American Society of Nephrology : Jasn. 13: 1586-94. PMID 12039988 DOI: 10.1097/01.Asn.0000016142.29721.22  0.36
2002 Landgrebe J, Welzl G, Metz T, van Gaalen MM, Ropers H, Wurst W, Holsboer F. Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling. Journal of Psychiatric Research. 36: 119-29. PMID 11886689 DOI: 10.1016/S0022-3956(01)00061-9  0.338
2002 Pfaar H, von Holst A, Vogt Weisenhorn DM, Brodski C, Guimera J, Wurst W. mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Development Genes and Evolution. 212: 43-6. PMID 11875656 DOI: 10.1007/S00427-001-0208-X  0.332
2002 Peñalva RG, Flachskamm C, Zimmermann S, Wurst W, Holsboer F, Reul JM, Linthorst AC. Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice. Neuroscience. 109: 253-66. PMID 11801362 DOI: 10.1016/S0306-4522(01)00475-4  0.344
2002 Floss T, Uez N, Frey S, Wurst W. Genotyping gene-trap mutant mice by real-time PCR Technical Tips Online. 7: 6-8. DOI: 10.1016/S1366-2120(08)70172-7  0.336
2001 Preil J, Müller MB, Gesing A, Reul JM, Sillaber I, van Gaalen MM, Landgrebe J, Holsboer F, Stenzel-Poore M, Wurst W. Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology. 142: 4946-55. PMID 11606463 DOI: 10.1210/Endo.142.11.8507  0.387
2001 Müller MB, Preil J, Renner U, Zimmermann S, Kresse AE, Stalla GK, Keck ME, Holsboer F, Wurst W. Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation. Endocrinology. 142: 4150-3. PMID 11517194 DOI: 10.1210/Endo.142.9.8491  0.344
2001 Cahana A, Escamez T, Nowakowski RS, Hayes NL, Giacobini M, von Holst A, Shmueli O, Sapir T, McConnell SK, Wurst W, Martinez S, Reiner O. Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proceedings of the National Academy of Sciences of the United States of America. 98: 6429-34. PMID 11344260 DOI: 10.1073/Pnas.101122598  0.346
2001 Simon HH, Saueressig H, Wurst W, Goulding MD, O'Leary DD. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3126-34. PMID 11312297 DOI: 10.1523/Jneurosci.21-09-03126.2001  0.392
2001 Vetter K, Wurst W. Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain. Mechanisms of Development. 100: 123-125. PMID 11118897 DOI: 10.1016/S0925-4773(00)00511-6  0.358
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Keck ME, Zimmermann S, Holsboer F, Wurst W. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Endocrinology. 141: 4262-9. PMID 11089561 DOI: 10.1210/Endo.141.11.7767  0.354
2000 Mainguy G, Montesinos ML, Lesaffre B, Zevnik B, Karasawa M, Kothary R, Wurst W, Prochiantz A, Volovitch M. An induction gene trap for identifying a homeoprotein-regulated locus. Nature Biotechnology. 18: 746-9. PMID 10888842 DOI: 10.1038/77312  0.349
2000 Müller MB, Keck ME, Zimmermann S, Holsboer F, Wurst W. Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids. Neuroreport. 11: 1963-6. PMID 10884052 DOI: 10.1097/00001756-200006260-00031  0.302
2000 Kimmel RA, Turnbull DH, Blanquet V, Wurst W, Loomis CA, Joyner AL. Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes & Development. 14: 1377-89. PMID 10837030 DOI: 10.1101/Gad.14.11.1377  0.378
2000 Wiles MV, Vauti F, Otte J, Füchtbauer EM, Ruiz P, Füchtbauer A, Arnold HH, Lehrach H, Metz T, Von Melchner H, Wurst W. Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells Nature Genetics. 24: 13-14. PMID 10615117 DOI: 10.1038/71622  0.362
2000 Bally-Cuif L, Goutel C, Wassef M, Wurst W, Rosa F. Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor Genes & Development. 14: 1664-1677. DOI: 10.1101/Gad.14.13.1664  0.364
2000 Preil J, Müller MB, Keck ME, Zimmermann S, Holsboer F, Wurst W. Disruption of feeding behaviour in corticotropin releasing hormone type-1 receptor (CRHR1) deficient mice is dependent on glucocorticoids European Neuropsychopharmacology. 10: 405. DOI: 10.1016/S0924-977X(00)80578-7  0.315
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Stalla GK, Keck ME, Zimmermann S, Holsboer F, Wurst W. Neuroendocrine regulation in mice deficient for the corticotropin-releasing hormone receptor 1 (CRHR1): activation of the vasopressinergic system and involvement of CRHR1 in adrenocortical function European Neuropsychopharmacology. 10: 404-405. DOI: 10.1016/S0924-977X(00)80577-5  0.333
1999 Mainguy G, Ernø H, Montesinos ML, Lesaffre B, Wurst W, Volovitch M, Prochiantz A. Regulation of epidermal bullous pemphigoid antigen 1 (BPAG1) synthesis by homeoprotein transcription factors. The Journal of Investigative Dermatology. 113: 643-50. PMID 10504454 DOI: 10.1046/J.1523-1747.1999.00703.X  0.332
1999 Broccoli V, Boncinelli E, Wurst W. The caudal limit of Otx2 expression positions the isthmic organizer. Nature. 401: 164-8. PMID 10490025 DOI: 10.1038/43670  0.325
1998 Hulander M, Wurst W, Carlsson P, Enerbäck S. The winged helix transcription factor Fkh10 is required for normal development of the inner ear. Nature Genetics. 20: 374-6. PMID 9843211 DOI: 10.1038/3850  0.381
1998 Sam M, Wurst W, Klüppel M, Jin O, Heng H, Bernstein A. Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif Developmental Dynamics. 212: 304-317. PMID 9626505 DOI: 10.1002/(Sici)1097-0177(199806)212:2<304::Aid-Aja15>3.0.Co;2-3  0.361
1998 Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520  0.316
1998 Holsboer F, Steckler T, Reul H, Barden N, Spanagel R, Wurst W. 260. Modulations of the HPA-system by mutagenesis in mice Biological Psychiatry. 43: S78. DOI: 10.1016/S0006-3223(98)90708-9  0.317
1997 Favor J, Sandulache R, Neuhäuser-Klaus A, Pretsch W, Chatterjee B, Senft E, Wurst W, Blanquet V, Grimes P, Spörle R, Schughart K. The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Proceedings of the National Academy of Sciences of the United States of America. 93: 13870-5. PMID 8943028 DOI: 10.1073/Pnas.93.24.13870  0.322
1996 Loomis CA, Harris E, Michaud J, Wurst W, Hanks M, Joyner AL. The mouse Engrailed-1 gene and ventral limb patterning. Nature. 382: 360-3. PMID 8684466 DOI: 10.1038/382360A0  0.328
1995 Hanks M, Wurst W, Anson-Cartwright L, Auerbach AB, Joyner AL. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science (New York, N.Y.). 269: 679-82. PMID 7624797 DOI: 10.1126/Science.7624797  0.363
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