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Year Citation  Score
2019 Fang F, Shi X, Brown MS, Goldstein JL, Liang G. Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30910968 DOI: 10.1073/pnas.1901867116  1
2018 Trinh MN, Brown MS, Seemann J, Goldstein JL, Lu F. Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1. Elife. 7. PMID 30047864 DOI: 10.7554/eLife.38564  1
2018 Tian J, Wu J, Chen X, Guo T, Chen ZJ, Goldstein JL, Brown MS. BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver. Elife. 7. PMID 29952285 DOI: 10.7554/eLife.36826  1
2017 Brown MS, Radhakrishnan A, Goldstein JL. Retrospective on Cholesterol Homeostasis: The Central Role of Scap. Annual Review of Biochemistry. PMID 28841344 DOI: 10.1146/annurev-biochem-062917-011852  1
2017 Gao Y, Zhou Y, Goldstein JL, Brown MS, Radhakrishnan A. Cholesterol-induced conformation changes in the sterol-sensing domain of the scap protein suggest feedback mechanism to control cholesterol synthesis. The Journal of Biological Chemistry. PMID 28377508 DOI: 10.1074/jbc.M117.783894  1
2016 Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL. Triazoles inhibit cholesterol export from lysosomes by binding to NPC1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27994139 DOI: 10.1073/pnas.1619571114  1
2016 Goldstein JL. The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon. Cell. PMID 27634320 DOI: 10.1016/j.cell.2016.08.040  1
2016 Tian J, Goldstein JL, Brown MS. Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382175 DOI: 10.1073/pnas.1608987113  1
2016 Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A. Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis. The Journal of Biological Chemistry. PMID 27068746 DOI: 10.1074/jbc.M116.729798  1
2015 Lu F, Liang Q, Abi-Mosleh L, Das A, De Brabander JK, Goldstein JL, Brown MS. Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection. Elife. 4. PMID 26646182 DOI: 10.7554/eLife.12177  1
2015 Goldstein JL. A Well-Hung Horse: Sired by Knowledge and Imagination. Cell. 162: 1179-82. PMID 26359973 DOI: 10.1016/j.cell.2015.08.039  1
2015 Goldstein JL, Brown MS. A century of cholesterol and coronaries: from plaques to genes to statins. Cell. 161: 161-72. PMID 25815993 DOI: 10.1016/j.cell.2015.01.036  1
2015 Brown CS, Lapin B, Wang C, Goldstein JL, Linn JG, Denham W, Haggerty SP, Talamonti MS, Howington JA, Carbray J, Ujiki MB. Reflux control is important in the management of Barrett's Esophagus: results from a retrospective 1,830 patient cohort. Surgical Endoscopy. PMID 25676204 DOI: 10.1007/s00464-015-4103-3  0.72
2015 Goldstein JL, Cryer B. Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies. Drug, Healthcare and Patient Safety. 7: 31-41. PMID 25653559 DOI: 10.2147/DHPS.S71976  0.72
2015 Zhang Y, Fang F, Goldstein JL, Brown MS, Zhao TJ. Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone. Proceedings of the National Academy of Sciences of the United States of America. 112: 1226-31. PMID 25583513 DOI: 10.1073/pnas.1423643112  1
2015 Yang A, Arndt DH, Berg RA, Carpenter JL, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, Nash KB, Payne ET, et al. Development and validation of a seizure prediction model in critically ill children. Seizure. 25: 104-11. PMID 25458097 DOI: 10.1016/j.seizure.2014.09.013  0.52
2014 Goldstein JL. Balzac's Unknown Masterpiece: spotting the next big thing in art and science. Nature Medicine. 20: 1106-11. PMID 25295945 DOI: 10.1038/nm.3676  1
2014 Whellan DJ, Goldstein JL, Cryer BL, Eisen GM, Lanas A, Miller AB, Scheiman JM, Fort JG, Zhang Y, O'Connor C. PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: results of two 6-month, phase 3 studies. American Heart Journal. 168: 495-502.e4. PMID 25262259 DOI: 10.1016/j.ahj.2014.05.017  0.72
2014 Das A, Brown MS, Anderson DD, Goldstein JL, Radhakrishnan A. Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife. 3. PMID 24920391 DOI: 10.7554/eLife.02882  1
2014 McFarlane MR, Brown MS, Goldstein JL, Zhao TJ. Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. Cell Metabolism. 20: 54-60. PMID 24836560 DOI: 10.1016/j.cmet.2014.04.007  1
2014 Brown CS, Lapin B, Wang C, Goldstein JL, Linn JG, Denham W, Haggerty SP, Talamonti MS, Howington JA, Carbray J, Ujiki MB. Predicting regression of Barrett's esophagus: results from a retrospective cohort of 1342 patients. Surgical Endoscopy. 28: 2803-7. PMID 24789137 DOI: 10.1007/s00464-014-3548-0  0.72
2014 Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, et al. Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 23: 87-97. PMID 24183923 DOI: 10.1016/j.seizure.2013.10.004  0.52
2014 Sánchez Fernández I, Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Matsumoto JH, McBain K, Nash KB, et al. Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. The Journal of Pediatrics. 164: 339-46.e1-2. PMID 24161223 DOI: 10.1016/j.jpeds.2013.09.032  0.52
2014 Nurse P, Goldstein JL, Brown MS, Greider C, Baltimore D. Emerging themes in biology: Hints for the future Cell. 157: 272-273. DOI: 10.1016/j.cell.2014.03.013  1
2013 Goldstein JL. Juxtapositions in Trafalgar Square: tip-offs to creativity in art and science. Nature Medicine. 19: 1222-6. PMID 24100991 DOI: 10.1038/nm.3329  1
2013 Sánchez SM, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, et al. Electroencephalography monitoring in critically ill children: current practice and implications for future study design. Epilepsia. 54: 1419-27. PMID 23848569 DOI: 10.1111/epi.12261  0.52
2013 Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, et al. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology. 81: 383-91. PMID 23794680 DOI: 10.1212/WNL.0b013e31829c5cfe  0.52
2013 Das A, Goldstein JL, Anderson DD, Brown MS, Radhakrishnan A. Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 10580-5. PMID 23754385 DOI: 10.1073/pnas.1309273110  1
2013 Masclee GM, Valkhoff VE, van Soest EM, Schade R, Mazzaglia G, Molokhia M, Trifirò G, Goldstein JL, Hernández-Díaz S, Kuipers EJ, Sturkenboom MC. Cyclo-oxygenase-2 inhibitors or nonselective NSAIDs plus gastroprotective agents: what to prescribe in daily clinical practice? Alimentary Pharmacology & Therapeutics. 38: 178-89. PMID 23710837 DOI: 10.1111/apt.12348  0.72
2013 Boike JR, Bortman JS, Radosta JM, Turner CL, Anderson-Shaw L, Centomani NM, Chamberlin WH, Mayer D, McDonald T, Goldstein JL. Patient safety event reporting expectation: does it influence residents' attitudes and reporting behaviors? Journal of Patient Safety. 9: 59-67. PMID 23697981 DOI: 10.1097/PTS.0b013e3182676e53  0.72
2013 Zhang Y, Motamed M, Seemann J, Brown MS, Goldstein JL. Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi. The Journal of Biological Chemistry. 288: 14059-67. PMID 23564452 DOI: 10.1074/jbc.M113.469528  1
2013 Sanchez SM, Carpenter J, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Kessler SK, Loddenkemper T, Riviello JJ, Abend NS. Pediatric ICU EEG monitoring: current resources and practice in the United States and Canada. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society. 30: 156-60. PMID 23545766 DOI: 10.1097/WNP.0b013e31827eda27  0.52
2013 Goldstein JL, Luo X, Cappelleri JC, Sands GH. Healthcare resource utilization and economic impact of a ≥2 g/dL decrease in hemoglobin in osteoarthritis patients. Journal of Medical Economics. 16: 430-9. PMID 23339465 DOI: 10.3111/13696998.2013.768529  0.72
2013 Rao VK, Haridas A, Nguyen TT, Lulla R, Wainwright MS, Goldstein JL. Symptomatic cerebral vasospasm following resection of a medulloblastoma in a child. Neurocritical Care. 18: 84-8. PMID 22911499 DOI: 10.1007/s12028-012-9769-y  0.52
2012 Goldstein JL, Brown MS. History of science. A golden era of Nobel laureates. Science (New York, N.Y.). 338: 1033-4. PMID 23180848 DOI: 10.1126/science.1231699  1
2012 Goldstein JL. Paradigm shifts in science: insights from the arts. Nature Medicine. 18: 1473-7. PMID 23042355 DOI: 10.1038/nm.2923  1
2012 Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proceedings of the National Academy of Sciences of the United States of America. 109: 16184-9. PMID 22927400 DOI: 10.1073/pnas.1213343109  1
2012 Lanas A, Goldstein JL, Chan FK, Wilcox CM, Peura DA, Li C, Sands GH, Scheiman JM. Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR). Alimentary Pharmacology & Therapeutics. 36: 485-92. PMID 22804104 DOI: 10.1111/j.1365-2036.2012.05213.x  0.72
2012 Boike JR, Kao R, Meyer D, Markle B, Rosenberg J, Niebruegge J, Stein AC, Berkes J, Goldstein JL. Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study. Alimentary Pharmacology & Therapeutics. 36: 391-7. PMID 22742578 DOI: 10.1111/j.1365-2036.2012.05200.x  0.72
2012 Brown MS, Goldstein JL. Scientific side trips: six excursions from the beaten path. The Journal of Biological Chemistry. 287: 22418-35. PMID 22584575 DOI: 10.1074/jbc.X112.381681  1
2012 Goldstein JL, VanCura BG. Letter: Mucosal injury with exposure to low-dose nonsteroidals. Alimentary Pharmacology & Therapeutics. 35: 1353. PMID 22548471 DOI: 10.1111/j.1365-2036.2012.05096.x  0.72
2012 Valkhoff VE, van Soest EM, Mazzaglia G, Molokhia M, Schade R, Trifiro G, Goldstein JL, Hernandez-Diaz S, Kuipers EJ, Sturkenboom MC. Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study. Arthritis and Rheumatism. 64: 2792-802. PMID 22508379 DOI: 10.1002/art.34433  0.72
2012 Li RL, Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, Zhao TJ. Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. The Journal of Biological Chemistry. 287: 17942-50. PMID 22474325 DOI: 10.1074/jbc.M112.358051  1
2012 Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metabolism. 15: 240-6. PMID 22326225 DOI: 10.1016/j.cmet.2011.12.017  1
2012 Roux C, Goldstein JL, Zhou X, Klemes A, Lindsay R. Vertebral fracture efficacy during risedronate therapy in patients using proton pump inhibitors. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of the Usa. 23: 277-84. PMID 21365461 DOI: 10.1007/s00198-011-1574-5  0.72
2011 Goldstein JL. The card players of Caravaggio, Cézanne and Mark Twain: tips for getting lucky in high-stakes research. Nature Medicine. 17: 1201-5. PMID 21989010 DOI: 10.1038/nm.2465  1
2011 Xie X, Brown MS, Shelton JM, Richardson JA, Goldstein JL, Liang G. Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 15330-5. PMID 21896731 DOI: 10.1073/pnas.1112751108  1
2011 Millichap JJ, Goldstein JL. Neurology Journal Club: a new subsection. Neurology. 77: 915-7. PMID 21876198 DOI: 10.1212/WNL.0b013e31822b00f0  0.52
2011 Goldstein JL, Chan FK, Lanas A, Wilcox CM, Peura D, Sands GH, Berger MF, Nguyen H, Scheiman JM. Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials. Alimentary Pharmacology & Therapeutics. 34: 808-16. PMID 21810115 DOI: 10.1111/j.1365-2036.2011.04790.x  0.72
2011 Goldstein JL, Zhao TJ, Li RL, Sherbet DP, Liang G, Brown MS. Surviving starvation: essential role of the ghrelin-growth hormone axis. Cold Spring Harbor Symposia On Quantitative Biology. 76: 121-7. PMID 21785007 DOI: 10.1101/sqb.2011.76.010447  1
2011 van Soest EM, Valkhoff VE, Mazzaglia G, Schade R, Molokhia M, Goldstein JL, Hernández-Díaz S, Trifirò G, Dieleman JP, Kuipers EJ, Sturkenboom MC. Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases. Gut. 60: 1650-9. PMID 21636644 DOI: 10.1136/gut.2011.239848  0.72
2011 Brown MS, Goldstein JL. Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis. The Journal of Cell Biology. 193: 601-3. PMID 21576388 DOI: 10.1083/jcb.201104136  1
2011 Motamed M, Zhang Y, Wang ML, Seemann J, Kwon HJ, Goldstein JL, Brown MS. Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis. The Journal of Biological Chemistry. 286: 18002-12. PMID 21454655 DOI: 10.1074/jbc.M111.238311  1
2011 Miller SM, Goldstein JL, Gerson LB. Cost-effectiveness model of endoscopic biopsy for eosinophilic esophagitis in patients with refractory GERD. The American Journal of Gastroenterology. 106: 1439-45. PMID 21448144 DOI: 10.1038/ajg.2011.94  0.72
2011 Millichap JJ, Goldstein JL, Laux LC, Nordli DR, Stack CV, Wainwright MS. Ictal asystole and anti-N-methyl-D-aspartate receptor antibody encephalitis. Pediatrics. 127: e781-6. PMID 21339268 DOI: 10.1542/peds.2010-2080  0.52
2011 Goldstein JL, Leonhardt D, Kmytyuk N, Kim F, Wang D, Wainwright MS. Abnormal neuroimaging is associated with early in-hospital seizures in pediatric abusive head trauma. Neurocritical Care. 15: 63-9. PMID 21042880 DOI: 10.1007/s12028-010-9468-5  0.52
2010 Millichap JJ, Goldstein JL. Teaching NeuroImages: long-term outcome of untreated Rasmussen syndrome. Neurology. 75: e85. PMID 21079177 DOI: 10.1212/WNL.0b013e3181fd636a  0.52
2010 Goldstein JL. How to win a Lasker? Take a close look at Bathers and Bulls. Nature Medicine. 16: 1091-6. PMID 20930751 DOI: 10.1038/nm1010-1091  1
2010 Goldstein JL, Jungwirthová A, David J, Spindel E, Bouchner L, PeÅ¡ek F, Searle S, Skopek J, Grim J, Ulč I, Sewell KL. Clinical trial: endoscopic evaluation of naproxen etemesil, a naproxen prodrug, vs. naproxen - a proof-of-concept, randomized, double-blind, active-comparator study. Alimentary Pharmacology & Therapeutics. 32: 1091-101. PMID 20804454 DOI: 10.1111/j.1365-2036.2010.04442.x  0.72
2010 Zhao TJ, Sakata I, Li RL, Liang G, Richardson JA, Brown MS, Goldstein JL, Zigman JM. Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 15868-73. PMID 20713709 DOI: 10.1073/pnas.1011116107  1
2010 Wang ML, Motamed M, Infante RE, Abi-Mosleh L, Kwon HJ, Brown MS, Goldstein JL. Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes. Cell Metabolism. 12: 166-73. PMID 20674861 DOI: 10.1016/j.cmet.2010.05.016  1
2010 Chan FK, Lanas A, Scheiman J, Berger MF, Nguyen H, Goldstein JL. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet. 376: 173-9. PMID 20638563 DOI: 10.1016/S0140-6736(10)60673-3  0.72
2010 Brown MS, Ye J, Goldstein JL. Medicine. HDL miR-ed down by SREBP introns. Science (New York, N.Y.). 328: 1495-6. PMID 20558698 DOI: 10.1126/science.1192409  1
2010 Goldstein JL, Hochberg MC, Fort JG, Zhang Y, Hwang C, Sostek M. Clinical trial: the incidence of NSAID-associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs. enteric-coated naproxen alone. Alimentary Pharmacology & Therapeutics. 32: 401-13. PMID 20497139 DOI: 10.1111/j.1365-2036.2010.04378.x  0.72
2010 Morgan D, Pandolfino J, Katz PO, Goldstein JL, Barker PN, Illueca M. Clinical trial: gastric acid suppression in Hispanic adults with symptomatic gastro-oesophageal reflux disease - comparator study of esomeprazole, lansoprazole and pantoprazole. Alimentary Pharmacology & Therapeutics. 32: 200-8. PMID 20456300 DOI: 10.1111/j.1365-2036.2010.04335.x  0.72
2010 Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 7467-72. PMID 20231469 DOI: 10.1073/pnas.1002271107  1
2010 Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 3441-6. PMID 20133650 DOI: 10.1073/pnas.0914798107  1
2010 Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G. Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. The Journal of Investigative Dermatology. 130: 1237-48. PMID 20090767 DOI: 10.1038/jid.2009.442  1
2010 Okazaki H, Goldstein JL, Brown MS, Liang G. LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size. The Journal of Biological Chemistry. 285: 6801-10. PMID 20037162 DOI: 10.1074/jbc.M109.079459  1
2010 Chan FK, Cryer B, Goldstein JL, Lanas A, Peura DA, Scheiman JM, Simon LS, Singh G, Stillman MJ, Wilcox CM, Berger MF, Breazna A, Dodge W. A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract. The Journal of Rheumatology. 37: 167-74. PMID 19884267 DOI: 10.3899/jrheum.090168  0.72
2010 Halpern R, Kothari S, Fuldeore M, Zarotsky V, Porter V, Dabbous O, Goldstein JL. GERD-related health care utilization, therapy, and reasons for transfer of GERD patients between primary care providers and gastroenterologists in a US managed care setting. Digestive Diseases and Sciences. 55: 328-37. PMID 19697131 DOI: 10.1007/s10620-009-0927-9  0.72
2010 Radhakrishnan A, Sun LP, Espenshade PJ, Goldstein JL, Brown MS. The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking Handbook of Cell Signaling, 2/E. 3: 2505-2510. DOI: 10.1016/B978-0-12-374145-5.00298-9  1
2010 Chan FKL, Lanas A, Scheiman J, Berger MF, Nguyen H, Goldstein JL. Celekoxib versus omeprazol a diklofenak u pacientů s osteoartrózou a revmatoidní artritidou (studie condor) Bolest. 13: 1-8.  0.72
2009 Abi-Mosleh L, Infante RE, Radhakrishnan A, Goldstein JL, Brown MS. Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 19316-21. PMID 19884502 DOI: 10.1073/pnas.0910916106  1
2009 Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL, Ye J. Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. The Journal of Biological Chemistry. 284: 34889-900. PMID 19815544 DOI: 10.1074/jbc.M109.044875  1
2009 Goldstein JL. Lasker Awards and papal portraiture: turning fields upside down. Nature Medicine. 15: 1137-40. PMID 19812573 DOI: 10.1038/nm1009-1137  1
2009 Guan HP, Goldstein JL, Brown MS, Liang G. Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. The Journal of Biological Chemistry. 284: 24644-52. PMID 19581301 DOI: 10.1074/jbc.M109.034397  1
2009 Kwon HJ, Abi-Mosleh L, Wang ML, Deisenhofer J, Goldstein JL, Brown MS, Infante RE. Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell. 137: 1213-24. PMID 19563754 DOI: 10.1016/j.cell.2009.03.049  1
2009 Goldstein JL, Brown MS. The LDL receptor. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 431-8. PMID 19299327 DOI: 10.1161/ATVBAHA.108.179564  1
2009 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 50: S15-27. PMID 18974038 DOI: 10.1194/jlr.R800054-JLR200  1
2008 Radhakrishnan A, Goldstein JL, McDonald JG, Brown MS. Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metabolism. 8: 512-21. PMID 19041766 DOI: 10.1016/j.cmet.2008.10.008  1
2008 Goldstein JL. Exuberant unpredictability: sine qua non for priceless and prizeworthy biomedical research. Nature Medicine. 14: 1029-32. PMID 18841142 DOI: 10.1038/nm1008-1029  1
2008 Infante RE, Wang ML, Radhakrishnan A, Kwon HJ, Brown MS, Goldstein JL. NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proceedings of the National Academy of Sciences of the United States of America. 105: 15287-92. PMID 18772377 DOI: 10.1073/pnas.0807328105  1
2008 Yang J, Zhao TJ, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 105: 10750-5. PMID 18669668 DOI: 10.1073/pnas.0805353105  1
2008 Goldstein JL, Brown MS. From fatty streak to fatty liver: 33 years of joint publications in the JCI. The Journal of Clinical Investigation. 118: 1220-2. PMID 18382725 DOI: 10.1172/JCI34973  1
2008 Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 132: 387-96. PMID 18267071 DOI: 10.1016/j.cell.2008.01.017  1
2008 Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metabolism. 7: 95-6. PMID 18249166 DOI: 10.1016/j.cmet.2007.12.009  1
2008 Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL. Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. The Journal of Biological Chemistry. 283: 1052-63. PMID 17989073 DOI: 10.1074/jbc.M707943200  1
2008 Infante RE, Radhakrishnan A, Abi-Mosleh L, Kinch LN, Wang ML, Grishin NV, Goldstein JL, Brown MS. Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. The Journal of Biological Chemistry. 283: 1064-75. PMID 17989072 DOI: 10.1074/jbc.M707944200  1
2008 Goldstein JL, Aisenberg J, Zakko SF, Berger MF, Dodge WE. Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial. Digestive Diseases and Sciences. 53: 647-56. PMID 17676393 DOI: 10.1007/s10620-007-9903-4  0.72
2008 Goldstein JL. Pediatric Neurology in the Emergency Department: Localization Followed by Differential Diagnosis Clinical Pediatric Emergency Medicine. 9: 67. DOI: 10.1016/j.cpem.2008.03.005  0.52
2007 Goldstein JL. Creation and revelation: two different routes to advancement in the biomedical sciences. Nature Medicine. 13: 1151-4. PMID 17917663 DOI: 10.1038/nm1642  1
2007 Goldstein JL, Cryer B, Amer F, Hunt B. Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 5: 1167-74. PMID 17916545 DOI: 10.1016/j.cgh.2007.06.009  0.72
2007 Goldstein JL, Johanson JF, Hawkey CJ, Suchower LJ, Brown KA. Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazole. Alimentary Pharmacology & Therapeutics. 26: 1101-11. PMID 17894652 DOI: 10.1111/j.1365-2036.2007.03460.x  0.72
2007 Sun SX, Lee KY, Bertram CT, Goldstein JL. Withdrawal of COX-2 selective inhibitors rofecoxib and valdecoxib: impact on NSAID and gastroprotective drug prescribing and utilization. Current Medical Research and Opinion. 23: 1859-66. PMID 17605893 DOI: 10.1185/030079907X210561  0.72
2007 Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Aisenberg J, Bhadra P, Berger MF. Small bowel mucosal injury is reduced in healthy subjects treated with celecoxib compared with ibuprofen plus omeprazole, as assessed by video capsule endoscopy. Alimentary Pharmacology & Therapeutics. 25: 1211-22. PMID 17451567 DOI: 10.1111/j.1365-2036.2007.03312.x  0.72
2007 Radhakrishnan A, Ikeda Y, Kwon HJ, Brown MS, Goldstein JL. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proceedings of the National Academy of Sciences of the United States of America. 104: 6511-8. PMID 17428920 DOI: 10.1073/pnas.0700899104  1
2007 Sun LP, Seemann J, Goldstein JL, Brown MS. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proceedings of the National Academy of Sciences of the United States of America. 104: 6519-26. PMID 17428919 DOI: 10.1073/pnas.0700907104  1
2007 Hawkey CJ, Jones RH, Yeomans ND, Scheiman JM, Talley NJ, Goldstein JL, Ahlbom H, Naesdal J. Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs. Alimentary Pharmacology & Therapeutics. 25: 813-21. PMID 17373920 DOI: 10.1111/j.1365-2036.2006.03210.x  0.72
2007 Markle BJ, Goldstein JL. On the other hand(s)......: Commentary Evidence-Based Gastroenterology. 8: 35-36. DOI: 10.1097/EBG.0b013e31805c9d0f  0.72
2006 Goldstein JL, Howard KB, Walton SM, McLaughlin TP, Kruzikas DT. Impact of adherence to concomitant gastroprotective therapy on nonsteroidal-related gastroduodenal ulcer complications. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 4: 1337-45. PMID 17088110 DOI: 10.1016/j.cgh.2006.08.016  0.72
2006 Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G. Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. The Journal of Clinical Investigation. 116: 2356-65. PMID 16955138 DOI: 10.1172/JCI28988  1
2006 Goldstein JL, Lowry SC, Lanza FL, Schwartz HI, Dodge WE. The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor. Alimentary Pharmacology & Therapeutics. 23: 1489-98. PMID 16669964 DOI: 10.1111/j.1365-2036.2006.02912.x  0.72
2006 Gong Y, Lee JN, Brown MS, Goldstein JL, Ye J. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 6154-9. PMID 16606821 DOI: 10.1073/pnas.0601923103  1
2006 Brown MS, Goldstein JL. Biomedicine. Lowering LDL--not only how low, but how long? Science (New York, N.Y.). 311: 1721-3. PMID 16556829 DOI: 10.1126/science.1125884  1
2006 Goldstein JL, DeBose-Boyd RA, Brown MS. Protein sensors for membrane sterols. Cell. 124: 35-46. PMID 16413480 DOI: 10.1016/j.cell.2005.12.022  1
2006 Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metabolism. 3: 15-24. PMID 16399501 DOI: 10.1016/j.cmet.2005.11.014  1
2005 Rosenberg JA, Goldstein JL. Safety and efficacy of lumiracoxib compared with NSAIDs. Nature Clinical Practice. Gastroenterology & Hepatology. 2: 14-5. PMID 16265092 DOI: 10.1038/ncpgasthep0067  0.72
2005 Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. The Journal of Clinical Investigation. 115: 2489-98. PMID 16100574 DOI: 10.1172/JCI25614  1
2005 Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metabolism. 1: 41-51. PMID 16054043 DOI: 10.1016/j.cmet.2004.11.004  1
2005 Sun LP, Li L, Goldstein JL, Brown MS. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. The Journal of Biological Chemistry. 280: 26483-90. PMID 15899885 DOI: 10.1074/jbc.M504041200  1
2005 Wang C, Gale M, Keller BC, Huang H, Brown MS, Goldstein JL, Ye J. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Molecular Cell. 18: 425-34. PMID 15893726 DOI: 10.1016/j.molcel.2005.04.004  1
2005 Feramisco JD, Radhakrishnan A, Ikeda Y, Reitz J, Brown MS, Goldstein JL. Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change. Proceedings of the National Academy of Sciences of the United States of America. 102: 3242-7. PMID 15728349 DOI: 10.1073/pnas.0500206102  1
2004 Goldstein JL, Huang B, Amer F, Christopoulos NG. Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. Clinical Therapeutics. 26: 1637-43. PMID 15598480 DOI: 10.1016/j.clinthera.2004.10.002  0.32
2004 Bilheimer DW, Grundy SM, Brown MS, Goldstein JL. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983. Atherosclerosis. Supplements. 5: 61-5. PMID 15531277 DOI: 10.1016/j.atherosclerosissup.2004.08.025  1
2004 Brown MS, Goldstein JL. Lowering plasma cholesterol by raising ldl receptors. 1981. Atherosclerosis. Supplements. 5: 57-9. PMID 15531276 DOI: 10.1016/j.atherosclerosissup.2004.08.024  1
2004 Adams CM, Reitz J, De Brabander JK, Feramisco JD, Li L, Brown MS, Goldstein JL. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. The Journal of Biological Chemistry. 279: 52772-80. PMID 15452130 DOI: 10.1074/jbc.M410302200  1
2004 Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proceedings of the National Academy of Sciences of the United States of America. 101: 11245-50. PMID 15266058 DOI: 10.1073/pnas.0404297101  1
2004 Radhakrishnan A, Sun LP, Kwon HJ, Brown MS, Goldstein JL. Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Molecular Cell. 15: 259-68. PMID 15260976 DOI: 10.1016/j.molcel.2004.06.019  1
2004 Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. The Journal of Clinical Investigation. 113: 1168-75. PMID 15085196 DOI: 10.1172/JCI20978  1
2004 Feramisco JD, Goldstein JL, Brown MS. Membrane topology of human insig-1, a protein regulator of lipid synthesis. The Journal of Biological Chemistry. 279: 8487-96. PMID 14660594 DOI: 10.1074/jbc.M312623200  1
2003 Goldstein JL, Zhao SZ, Burke TA, Palmer R, von Allmen H, Henderson SC. Incidence of outpatient physician claims for upper gastrointestinal symptoms among new users of celecoxib, ibuprofen, and naproxen in an insured population in the United States. The American Journal of Gastroenterology. 98: 2627-34. PMID 14687808 DOI: 10.1111/j.1572-0241.2003.08722.x  0.72
2003 Ye J, Wang C, Sumpter R, Brown MS, Goldstein JL, Gale M. Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proceedings of the National Academy of Sciences of the United States of America. 100: 15865-70. PMID 14668447 DOI: 10.1073/pnas.2237238100  1
2003 Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. The Journal of Biological Chemistry. 278: 52479-90. PMID 14563840 DOI: 10.1074/jbc.M310053200  1
2003 Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proceedings of the National Academy of Sciences of the United States of America. 100: 12027-32. PMID 14512514 DOI: 10.1073/pnas.1534923100  1
2003 Adams CM, Goldstein JL, Brown MS. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proceedings of the National Academy of Sciences of the United States of America. 100: 10647-52. PMID 12963821 DOI: 10.1073/pnas.1534833100  1
2003 Goldstein JL, Kivitz AJ, Verburg KM, Recker DP, Palmer RC, Kent JD. A comparison of the upper gastrointestinal mucosal effects of valdecoxib, naproxen and placebo in healthy elderly subjects. Alimentary Pharmacology & Therapeutics. 18: 125-32. PMID 12848634 DOI: 10.1046/j.1365-2036.2003.01650.x  0.72
2003 Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. The Journal of Biological Chemistry. 278: 35837-43. PMID 12842885 DOI: 10.1074/jbc.M306476200  1
2003 Kasus-Jacobi A, Ou J, Bashmakov YK, Shelton JM, Richardson JA, Goldstein JL, Brown MS. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 278: 32380-9. PMID 12807874 DOI: 10.1074/jbc.M304969200  1
2003 Faigel DO, Eisen GM, Baron TH, Dominitz JA, Goldstein JL, Hirota WK, Jacobson BC, Johanson JF, Leighton JA, Mallery JS, Peterson KA, Raddawi HM, Varg JJ, Waring JP, Fanelli RD, et al. Tissue sampling and analysis. Gastrointestinal Endoscopy. 57: 811-6. PMID 12776025 DOI: 10.1016/S0016-5107(03)70047-9  0.72
2003 Faigel DO, Eisen GM, Baron TH, Dominitz JA, Goldstein JL, Hirota WK, Jacobson BC, Johanson JF, Leighton JA, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J, et al. Preparation of patients for GI endoscopy. Gastrointestinal Endoscopy. 57: 446-50. PMID 12665751 DOI: 10.1016/S0016-5107(03)80006-8  0.72
2003 Dominitz JA, Eisen GM, Baron TH, Goldstein JL, Hirota WK, Jacobson BC, Johanson JF, Leighton JA, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J, Faigel DO, et al. Complications of colonoscopy. Gastrointestinal Endoscopy. 57: 441-5. PMID 12665750 DOI: 10.1016/S0016-5107(03)80005-6  0.72
2003 Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 3155-60. PMID 12624180 DOI: 10.1073/pnas.0130116100  1
2003 Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Molecular Cell. 11: 25-33. PMID 12535518 DOI: 10.1016/S1097-2765(02)00822-5  1
2002 Horton JD, Goldstein JL, Brown MS. SREBPs: transcriptional mediators of lipid homeostasis. Cold Spring Harbor Symposia On Quantitative Biology. 67: 491-8. PMID 12858575  1
2002 Goldstein JL, Brown MS. Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002. The Journal of Clinical Investigation. 110: S11-3. PMID 12506883  1
2002 Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J. Structure of the LDL receptor extracellular domain at endosomal pH. Science (New York, N.Y.). 298: 2353-8. PMID 12459547 DOI: 10.1126/science.1078124  1
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbaugh J. Open access endoscopy. Gastrointestinal Endoscopy. 56: 793-5. PMID 12447287 DOI: 10.1016/S0016-5107(02)70349-0  0.72
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbaugh J. Acute colonic pseudo-obstruction. Gastrointestinal Endoscopy. 56: 789-92. PMID 12447286 DOI: 10.1016/S0016-5107(02)70348-9  0.72
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbaugh J. The role of endoscopic therapy in the management of variceal hemorrhage. Gastrointestinal Endoscopy. 56: 618-20. PMID 12397264 DOI: 10.1016/S0016-5107(02)70105-3  0.72
2002 Faigel DO, Baron TH, Goldstein JL, Hirota WK, Jacobson BC, Johanson JF, Leighton JA, Mallery JS, Peterson KA, Waring JP, Fanelli RD, Wheeler-Harbaugh J. Guidelines for the use of deep sedation and anesthesia for GI endoscopy. Gastrointestinal Endoscopy. 56: 613-7. PMID 12397263 DOI: 10.1016/S0016-5107(02)70104-1  0.72
2002 Campbell DR, Haber MM, Sheldon E, Collis C, Lukasik N, Huang B, Goldstein JL. Effect of H. pylori status on gastric ulcer healing in patients continuing nonsteroidal anti-inflammatory therapy and receiving treatment with lansoprazole or ranitidine. The American Journal of Gastroenterology. 97: 2208-14. PMID 12358234 DOI: 10.1111/j.1572-0241.2002.05774.x  0.32
2002 Yabe D, Brown MS, Goldstein JL. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 99: 12753-8. PMID 12242332 DOI: 10.1073/pnas.162488899  1
2002 Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 110: 489-500. PMID 12202038 DOI: 10.1016/S0092-8674(02)00872-3  1
2002 Brown AJ, Sun L, Feramisco JD, Brown MS, Goldstein JL. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Molecular Cell. 10: 237-45. PMID 12191470 DOI: 10.1016/S1097-2765(02)00591-9  1
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J. Guideline for the management of ingested foreign bodies. Gastrointestinal Endoscopy. 55: 802-6. PMID 12024131  0.72
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J. Role of endoscopy in enteral feeding. Gastrointestinal Endoscopy. 55: 794-7. PMID 12024129  0.72
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J. Complications of upper GI endoscopy. Gastrointestinal Endoscopy. 55: 784-93. PMID 12024128  0.72
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J. Methods of granting hospital privileges to perform gastrointestinal endoscopy. Gastrointestinal Endoscopy. 55: 780-3. PMID 12024127  0.72
2002 Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, Mallery JS, Raddawi HM, Vargo JJ, Waring JP, Fanelli RD, Wheeler-Harbough J. Guideline on the management of anticoagulation and antiplatelet therapy for endoscopic procedures. Gastrointestinal Endoscopy. 55: 775-9. PMID 12024126  0.72
2002 Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. The Journal of Clinical Investigation. 109: 1125-31. PMID 11994399 DOI: 10.1172/JCI15593  1
2002 Dobrosotskaya IY, Seegmiller AC, Brown MS, Goldstein JL, Rawson RB. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science (New York, N.Y.). 296: 879-83. PMID 11988566 DOI: 10.1126/science.1071124  1
2002 Seegmiller AC, Dobrosotskaya I, Goldstein JL, Ho YK, Brown MS, Rawson RB. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Developmental Cell. 2: 229-38. PMID 11832248 DOI: 10.1016/S1534-5807(01)00119-8  1
2002 Goldstein JL, Rawson RB, Brown MS. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Archives of Biochemistry and Biophysics. 397: 139-48. PMID 11795864 DOI: 10.1006/abbi.2001.2615  1
2002 Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. The Journal of Biological Chemistry. 277: 9520-8. PMID 11782483 DOI: 10.1074/jbc.M111421200  1
2001 Yang J, Goldstein JL, Hammer RE, Moon YA, Brown MS, Horton JD. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proceedings of the National Academy of Sciences of the United States of America. 98: 13607-12. PMID 11717426 DOI: 10.1073/pnas.201524598  1
2001 Goldstein JL, Larson LR, Yamashita BD, Fain JM, Schumock GT. Low molecular weight heparin versus unfractionated heparin in the colonoscopy peri-procedure period: a cost modeling study. The American Journal of Gastroenterology. 96: 2360-6. PMID 11513175 DOI: 10.1111/j.1572-0241.2001.04046.x  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. Ethnic issues in endoscopy. Gastrointestinal Endoscopy. 53: 874-5. PMID 11375622  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. Enteroscopy. Gastrointestinal Endoscopy. 53: 871-3. PMID 11375621  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen JL, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. Endoscopic therapy of anorectal disorders. Gastrointestinal Endoscopy. 53: 867-70. PMID 11375620  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. An annotated algorithm for the evaluation of choledocholithiasis. Gastrointestinal Endoscopy. 53: 864-6. PMID 11375619  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. An annotated algorithmic approach to acute lower gastrointestinal bleeding. Gastrointestinal Endoscopy. 53: 859-63. PMID 11375618  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. An annotated algorithmic approach to upper gastrointestinal bleeding. Gastrointestinal Endoscopy. 53: 853-8. PMID 11375617  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. An annotated algorithmic approach to malignant biliary obstruction. Gastrointestinal Endoscopy. 53: 849-52. PMID 11375616  0.72
2001 Eisen GM, Dominitz JA, Faigel DO, Goldstein JL, Kalloo AN, Petersen BT, Raddawi HM, Ryan ME, Vargo JJ, Young HS, Fanelli RD, Hyman NH, Wheeler-Harbaugh J. Guidelines for advanced endoscopic training. Gastrointestinal Endoscopy. 53: 846-8. PMID 11375615  0.72
2001 Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proceedings of the National Academy of Sciences of the United States of America. 98: 6027-32. PMID 11371634 DOI: 10.1073/pnas.111138698  1
2001 Goldstein JL, Brown MS. Molecular medicine. The cholesterol quartet. Science (New York, N.Y.). 292: 1310-2. PMID 11360986 DOI: 10.1126/science.1061815  1
2001 Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes & Development. 15: 1206-16. PMID 11358865 DOI: 10.1101/gad.891301  1
2001 Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proceedings of the National Academy of Sciences of the United States of America. 98: 3756-61. PMID 11259670 DOI: 10.1073/pnas.071054598  1
2001 DeBose-Boyd RA, Ou J, Goldstein JL, Brown MS. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proceedings of the National Academy of Sciences of the United States of America. 98: 1477-82. PMID 11171976 DOI: 10.1073/pnas.98.4.1477  1
2001 Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. The Journal of Biological Chemistry. 276: 4365-72. PMID 11085986 DOI: 10.1074/jbc.M007273200  1
2000 Eisen GM, Chutkan R, Goldstein JL, Petersen BT, Ryan ME, Sherman S, Vargo JJ, Wright RA, Young HS, Catalano MF, Dentsman F, Smith CD, Walter. Role of endoscopic ultrasonography. Gastrointestinal Endoscopy. 52: 852-859. PMID 11182690  0.72
2000 Eisen GM, Chutkan R, Goldstein JL, Petersen BT, Ryan ME, Sherman S, Vargo JJ, Wright RA, Young HS, Catalano MF, Dentsman F, Smith CD, Walter. Modifications in endoscopic practice for the elderly. Gastrointestinal Endoscopy. 52: 849-851. PMID 11182689  0.72
2000 Eisen GM, Chutkan R, Goldstein JL, Petersen BT, Ryan ME, Sherman S, Vargo JJ, Wright RA, Young HS, Catalano MF, Dentsman F, Smith CD, Walter. Endoscopic therapy of chronic pancreatitis. Gastrointestinal Endoscopy. 52: 843-848. PMID 11182688  0.72
2000 Eisen GM, Chutkan R, Goldstein JL, Petersen BT, Ryan ME, Sherman S, Vargo JJ, Wright RA, Young HS, Catalano MF, Denstman F, Smith CD, Walter. Modifications in endoscopic practice for pediatric patients. Gastrointestinal Endoscopy. 52: 838-842. PMID 11182687  0.72
2000 Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Molecular Cell. 6: 1355-64. PMID 11163209 DOI: 10.1016/S1097-2765(00)00133-7  1
2000 Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes & Development. 14: 2819-30. PMID 11090130 DOI: 10.1101/gad.844900  1
2000 Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. Jama. 284: 1247-55. PMID 10979111  0.72
2000 Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell. 102: 315-23. PMID 10975522  1
2000 Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Molecular Cell. 6: 77-86. PMID 10949029  1
2000 Yang T, Goldstein JL, Brown MS. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum. The Journal of Biological Chemistry. 275: 29881-6. PMID 10896675 DOI: 10.1074/jbc.M005439200  1
2000 Luong A, Hannah VC, Brown MS, Goldstein JL. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 275: 26458-66. PMID 10843999 DOI: 10.1074/jbc.M004160200  1
2000 Ye J, Davé UP, Grishin NV, Goldstein JL, Brown MS. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Proceedings of the National Academy of Sciences of the United States of America. 97: 5123-8. PMID 10805775 DOI: 10.1073/pnas.97.10.5123  1
2000 Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell. 100: 391-8. PMID 10693756  1
1999 DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell. 99: 703-12. PMID 10619424  1
1999 Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS, Goldstein JL. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America. 96: 13656-61. PMID 10570128 DOI: 10.1073/pnas.96.24.13656  1
1999 Goldstein JL, Brown MS. Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar. Proceedings of the Association of American Physicians. 111: 469-79. PMID 10519168  1
1999 Nohturfft A, DeBose-Boyd RA, Scheek S, Goldstein JL, Brown MS. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proceedings of the National Academy of Sciences of the United States of America. 96: 11235-40. PMID 10500160  1
1999 Brown MS, Goldstein JL. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proceedings of the National Academy of Sciences of the United States of America. 96: 11041-8. PMID 10500120  1
1999 Rawson RB, DeBose-Boyd R, Goldstein JL, Brown MS. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. The Journal of Biological Chemistry. 274: 28549-56. PMID 10497220  1
1999 Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 401: 73-6. PMID 10485707 DOI: 10.1038/43448  1
1999 Goldstein JL, Brown MS. Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar. The Journal of Clinical Investigation. 104: S19-37. PMID 10453253  1
1999 Cheng D, Espenshade PJ, Slaughter CA, Jaen JC, Brown MS, Goldstein JL. Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 22805-12. PMID 10428865 DOI: 10.1074/jbc.274.32.22805  1
1999 Espenshade PJ, Cheng D, Goldstein JL, Brown MS. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 22795-804. PMID 10428864 DOI: 10.1074/jbc.274.32.22795  1
1999 Zelenski NG, Rawson RB, Brown MS, Goldstein JL. Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 274: 21973-80. PMID 10419520  1
1999 Lanza RP, Arrow KJ, Axelrod J, Baltimore D, Benacerraf B, Bloch KE, Bloembergen N, Brown HC, Brown MS, Cibelli JB, Cohen S, Cooper LN, Corey EJ, Dulbecco R, Fischer EH, ... ... Goldstein JL, et al. Science over politics. Science (New York, N.Y.). 283: 1849-50. PMID 10206888  1
1999 Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL. Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL. The Journal of Clinical Investigation. 103: 1067-76. PMID 10194480 DOI: 10.1172/JCI6246  1
1998 Goldstein JL, Larson LR, Yamashita BD. Prevention of nonsteroidal anti-inflammatory drug-induced gastropathy: clinical and economic implications of a single-tablet formulation of diclofenac/misoprostol. The American Journal of Managed Care. 4: 687-97. PMID 10179922  0.72
1998 Korn BS, Shimomura I, Bashmakov Y, Hammer RE, Horton JD, Goldstein JL, Brown MS. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). The Journal of Clinical Investigation. 102: 2050-60. PMID 9854040 DOI: 10.1172/JCI5341  1
1998 Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Molecular Cell. 2: 505-14. PMID 9809072  1
1998 Nohturfft A, Brown MS, Goldstein JL. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. Proceedings of the National Academy of Sciences of the United States of America. 95: 12848-53. PMID 9789003  1
1998 Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes & Development. 12: 3182-94. PMID 9784493  1
1998 Rawson RB, Cheng D, Brown MS, Goldstein JL. Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1. The Journal of Biological Chemistry. 273: 28261-9. PMID 9774448  1
1998 Sahi J, Nataraja SG, Layden TJ, Goldstein JL, Moyer MP, Rao MC. Cl- transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon. The American Journal of Physiology. 275: C1048-57. PMID 9755058  0.72
1998 Pai JT, Guryev O, Brown MS, Goldstein JL. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. The Journal of Biological Chemistry. 273: 26138-48. PMID 9748295  1
1998 Duncan EA, Davé UP, Sakai J, Goldstein JL, Brown MS. Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning. The Journal of Biological Chemistry. 273: 17801-9. PMID 9651382  1
1998 Nohturfft A, Brown MS, Goldstein JL. Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain. The Journal of Biological Chemistry. 273: 17243-50. PMID 9642295  1
1998 Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. The Journal of Clinical Investigation. 101: 2331-9. PMID 9616204 DOI: 10.1172/JCI2961  1
1998 Brown MS, Goldstein JL. Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake. Nutrition Reviews. 56: S1-3; discussion S54. PMID 9564170  1
1998 Sakai J, Nohturfft A, Goldstein JL, Brown MS. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. The Journal of Biological Chemistry. 273: 5785-93. PMID 9488713  1
1998 Carpizo DR, Reaka AJ, Glaws WR, Pooley N, Schmidt L, Halline AG, Goldstein JL, Layden TJ. Acute acid exposure increases rabbit esophageal cell proliferation. The Journal of Laboratory and Clinical Medicine. 131: 157-62. PMID 9488499  0.72
1997 Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Molecular Cell. 1: 47-57. PMID 9659902  1
1997 Goldstein JL, Larson LR, Yamashita BD, Boyd MS. Management of NSAID-induced gastropathy: an economic decision analysis. Clinical Therapeutics. 19: 1496-509; discussion. PMID 9444455 DOI: 10.1016/S0149-2918(97)80021-5  0.72
1997 Shimomura I, Bashmakov Y, Shimano H, Horton JD, Goldstein JL, Brown MS. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proceedings of the National Academy of Sciences of the United States of America. 94: 12354-9. PMID 9356453  1
1997 Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. The Journal of Clinical Investigation. 100: 2115-24. PMID 9329978 DOI: 10.1172/JCI119746  1
1997 Scheek S, Brown MS, Goldstein JL. Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 11179-83. PMID 9326582  1
1997 Brown MS, Herz J, Goldstein JL. LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature. 388: 629-30. PMID 9262394 DOI: 10.1038/41672  1
1997 Sakai J, Nohturfft A, Cheng D, Ho YK, Brown MS, Goldstein JL. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. The Journal of Biological Chemistry. 272: 20213-21. PMID 9242699  1
1997 Goldstein JL, Brown MS. The clinical investigator: bewitched, bothered, and bewildered--but still beloved. The Journal of Clinical Investigation. 99: 2803-12. PMID 9185499 DOI: 10.1172/JCI119470  1
1997 Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89: 331-40. PMID 9150132  1
1997 Duncan EA, Brown MS, Goldstein JL, Sakai J. Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2. The Journal of Biological Chemistry. 272: 12778-85. PMID 9139737  1
1997 Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. The Journal of Clinical Investigation. 99: 846-54. PMID 9062341 DOI: 10.1172/JCI119248  1
1997 Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. The Journal of Clinical Investigation. 99: 838-45. PMID 9062340 DOI: 10.1172/JCI119247  1
1996 Nohturfft A, Hua X, Brown MS, Goldstein JL. Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proceedings of the National Academy of Sciences of the United States of America. 93: 13709-14. PMID 8942999  1
1996 Hua X, Nohturfft A, Goldstein JL, Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell. 87: 415-26. PMID 8898195  1
1996 Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. The Journal of Clinical Investigation. 98: 1575-84. PMID 8833906 DOI: 10.1172/JCI118951  1
1996 Brown MS, Goldstein JL. Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 44: 14-23. PMID 8689397  1
1996 Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 85: 1037-46. PMID 8674110  1
1996 Cao G, Goldstein JL, Brown MS. Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells. The Journal of Biological Chemistry. 271: 14642-8. PMID 8662991  1
1996 Pai JT, Brown MS, Goldstein JL. Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 93: 5437-42. PMID 8643593  1
1996 James G, Goldstein JL, Brown MS. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 4454-8. PMID 8633088  1
1996 Hua X, Sakai J, Brown MS, Goldstein JL. Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane. The Journal of Biological Chemistry. 271: 10379-84. PMID 8626610  1
1996 Brown MS, Goldstein JL. Heart attacks: gone with the century? Science (New York, N.Y.). 272: 629. PMID 8614809  1
1996 Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. The Embo Journal. 15: 1012-20. PMID 8605870  1
1995 Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America. 92: 8453-7. PMID 7667310  1
1995 Wang X, Pai JT, Wiedenfeld EA, Medina JC, Slaughter CA, Goldstein JL, Brown MS. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. The Journal of Biological Chemistry. 270: 18044-50. PMID 7629113 DOI: 10.1074/jbc.270.30.18044  1
1995 Hua X, Sakai J, Ho YK, Goldstein JL, Brown MS. Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. The Journal of Biological Chemistry. 270: 29422-7. PMID 7493979  1
1994 Ishibashi S, Herz J, Maeda N, Goldstein JL, Brown MS. The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proceedings of the National Academy of Sciences of the United States of America. 91: 4431-5. PMID 8183926  1
1994 Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. The Journal of Clinical Investigation. 93: 1885-93. PMID 8182121 DOI: 10.1172/JCI117179  1
1994 Wang X, Sato R, Brown MS, Hua X, Goldstein JL. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77: 53-62. PMID 8156598  1
1994 Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). The Journal of Biological Chemistry. 269: 17267-73. PMID 8006035  1
1993 Armstrong SA, Seabra MC, Südhof TC, Goldstein JL, Brown MS. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. The Journal of Biological Chemistry. 268: 12221-9. PMID 8505342  1
1993 Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 75: 187-97. PMID 8402897  1
1993 Briggs MR, Yokoyama C, Wang X, Brown MS, Goldstein JL. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. The Journal of Biological Chemistry. 268: 14490-6. PMID 8390995  1
1993 Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. The Journal of Clinical Investigation. 92: 883-93. PMID 8349823 DOI: 10.1172/JCI116663  1
1993 Wang X, Briggs MR, Hua X, Yokoyama C, Goldstein JL, Brown MS. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. The Journal of Biological Chemistry. 268: 14497-504. PMID 8314806  1
1993 Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proceedings of the National Academy of Sciences of the United States of America. 90: 11603-7. PMID 7903453  1
1992 Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL. Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Cell. 70: 1049-57. PMID 1525821  1
1992 Willnow TE, Goldstein JL, Orth K, Brown MS, Herz J. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. The Journal of Biological Chemistry. 267: 26172-80. PMID 1464627  1
1992 Seabra MC, Goldstein JL, Südhof TC, Brown MS. Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. The Journal of Biological Chemistry. 267: 14497-503. PMID 1321151  1
1991 Herz J, Goldstein JL, Strickland DK, Ho YK, Brown MS. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. The Journal of Biological Chemistry. 266: 21232-8. PMID 1718973  1
1990 Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 10771-9. PMID 2355022  1
1990 Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS. Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 22453-9. PMID 2266137  1
1990 Herz J, Kowal RC, Ho YK, Brown MS, Goldstein JL. Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. The Journal of Biological Chemistry. 265: 21355-62. PMID 2250029  1
1990 Herz J, Kowal RC, Goldstein JL, Brown MS. Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment. The Embo Journal. 9: 1769-76. PMID 2112085  1
1989 Kowal RC, Herz J, Goldstein JL, Esser V, Brown MS. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 5810-4. PMID 2762297  1
1988 Dawson PA, Hofmann SL, van der Westhuyzen DR, Südhof TC, Brown MS, Goldstein JL. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. The Journal of Biological Chemistry. 263: 3372-9. PMID 3277969  1
1987 Südhof TC, Van der Westhuyzen DR, Goldstein JL, Brown MS, Russell DW. Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. The Journal of Biological Chemistry. 262: 10773-9. PMID 3611089  1
1987 Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature. 326: 760-5. PMID 3494949 DOI: 10.1038/326760a0  1
1987 van Driel IR, Goldstein JL, Südhof TC, Brown MS. First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. The Journal of Biological Chemistry. 262: 17443-9. PMID 3320043  1
1987 Südhof TC, Russell DW, Brown MS, Goldstein JL. 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell. 48: 1061-9. PMID 3030558  1
1986 Russell DW, Lehrman MA, Südhof TC, Yamamoto T, Davis CG, Hobbs HH, Brown MS, Goldstein JL. The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. Cold Spring Harbor Symposia On Quantitative Biology. 51: 811-9. PMID 3472763  1
1986 Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL, Brown MS. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proceedings of the National Academy of Sciences of the United States of America. 83: 8370-4. PMID 3464957  1
1985 Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI. Cassette of eight exons shared by genes for LDL receptor and EGF precursor. Science (New York, N.Y.). 228: 893-5. PMID 3873704  1
1985 Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW. Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (New York, N.Y.). 227: 140-6. PMID 3155573  1
1985 Südhof TC, Goldstein JL, Brown MS, Russell DW. The LDL receptor gene: a mosaic of exons shared with different proteins. Science (New York, N.Y.). 228: 815-22. PMID 2988123  1
1983 Daniel TO, Schneider WJ, Goldstein JL, Brown MS. Visualization of lipoprotein receptors by ligand blotting. The Journal of Biological Chemistry. 258: 4606-11. PMID 6300091  1
1981 Krieger M, Brown MS, Goldstein JL. Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. Journal of Molecular Biology. 150: 167-84. PMID 6275086  1
1980 Chen GC, Krieger M, Kane JP, Wu CS, Brown MS, Goldstein JL. beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism. Biochemistry. 19: 4706-12. PMID 7426623  1
1980 Krieger M, Peterson J, Goldstein JL, Brown MS. Mobility of apolar lipids of reconstituted low density lipoprotein as monitored by electron spin resonance spectroscopy. The Journal of Biological Chemistry. 255: 3330-3. PMID 6245076  1
1979 Krieger M, Smith LC, Anderson RG, Goldstein JL, Kao YJ, Pownall HJ, Gotto AM, Brown MS. Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells. Journal of Supramolecular Structure. 10: 467-78. PMID 229357 DOI: 10.1002/jss.400100409  1
1979 Brown MS, Goldstein JL, Krieger M, Ho YK, Anderson RG. Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins. The Journal of Cell Biology. 82: 597-613. PMID 229107  1
1979 Goldstein JL, Brown MS, Krieger M, Anderson RG, Mintz B. Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 76: 2843-7. PMID 223161 DOI: 10.1073/pnas.76.6.2843  1
1979 Krieger M, McPhaul MJ, Goldstein JL, Brown MS. Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids. The Journal of Biological Chemistry. 254: 3845-53. PMID 220222  1
1978 Krieger M, Goldstein JL, Brown MS. Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 75: 5052-6. PMID 217011  1
1978 Krieger M, Brown MS, Faust JR, Goldstein JL. Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle. The Journal of Biological Chemistry. 253: 4093-101. PMID 207690  1
1974 Goldstein JL, Albers JJ, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids. American Journal of Human Genetics. 26: 727-35. PMID 4440681  1
1974 Ott J, Schrott HG, Goldstein JL, Hazzard WR, Allen FH, Falk CT, Motulsky AG. Linkage studies in a large kindred with familial hypercholesterolemia. American Journal of Human Genetics. 26: 598-603. PMID 4213615  1
1973 Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. The Journal of Clinical Investigation. 52: 1544-68. PMID 4718953 DOI: 10.1172/JCI107332  1
1973 Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. The Journal of Clinical Investigation. 52: 1533-43. PMID 4718952 DOI: 10.1172/JCI107331  1
1973 Hazzard WR, Goldstein JL, Schrott MG, Motulsky AG, Bierman EL. Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction. The Journal of Clinical Investigation. 52: 1569-77. PMID 4352458 DOI: 10.1172/JCI107333  1
1972 Schrott HG, Goldstein JL, Hazzard WR, McGoodwin MM, Motulsky AG. Familial hypercholesterolemia in a large indred. Evidence for a monogenic mechanism. Annals of Internal Medicine. 76: 711-20. PMID 5025321  1
1972 Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. Genetics of hyperlipidemia in coronary heart disease. Transactions of the Association of American Physicians. 85: 120-38. PMID 4349620  1
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