Karl H. Weisgraber - Publications

Affiliations: 
Gladstone Institute, UCSF, San Francisco, CA, United States 
Area:
apolipoprotein E

206 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Adeosun SO, Hou X, Zheng B, Stockmeier C, Ou X, Paul I, Mosley T, Weisgraber K, Wang JM. Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction. The Journal of Biological Chemistry. 289: 2946-59. PMID 24324264 DOI: 10.1074/jbc.M113.497909  1
2012 Zhang L, Yan F, Zhang S, Lei D, Charles MA, Cavigiolio G, Oda M, Krauss RM, Weisgraber KH, Rye KA, Pownall HJ, Qiu X, Ren G. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nature Chemical Biology. 8: 342-9. PMID 22344176 DOI: 10.1038/nchembio.796  1
2012 Peters-Libeu C, Miller J, Rutenber E, Newhouse Y, Krishnan P, Cheung K, Hatters D, Brooks E, Widjaja K, Tran T, Mitra S, Arrasate M, Mosquera LA, Taylor D, Weisgraber KH, et al. Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure. Journal of Molecular Biology. 421: 587-600. PMID 22306738 DOI: 10.1016/j.jmb.2012.01.034  1
2012 Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, ... Weisgraber KH, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. The Journal of Biological Chemistry. 287: 5253-66. PMID 22158868 DOI: 10.1074/jbc.M111.276162  1
2011 Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, ... ... Weisgraber KH, et al. Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nature Chemical Biology. 7: 925-34. PMID 22037470 DOI: 10.1038/nchembio.694  1
2011 Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, ... ... Weisgraber KH, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. The Journal of Biological Chemistry. 286: 17217-26. PMID 21454574 DOI: 10.1074/jbc.M110.217380  1
2011 Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. The Journal of Biological Chemistry. 286: 5215-21. PMID 21118811 DOI: 10.1074/jbc.M110.151084  1
2011 Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. Journal of Lipid Research. 52: 175-84. PMID 20978167 DOI: 10.1194/jlr.D010959  1
2011 Newhouse Y, Weisgraber KH. Apolipoprotein E expression and purification. Methods in Molecular Biology (Clifton, N.J.). 670: 127-40. PMID 20967588 DOI: 10.1007/978-1-60761-744-0_10  1
2010 Zhang L, Song J, Newhouse Y, Zhang S, Weisgraber KH, Ren G. An optimized negative-staining protocol of electron microscopy for apoE4 POPC lipoprotein. Journal of Lipid Research. 51: 1228-36. PMID 19965615 DOI: 10.1194/jlr.D002493  1
2010 Tetali SD, Budamagunta MS, Simion C, den Hartigh LJ, Kálai T, Hideg K, Hatters DM, Weisgraber KH, Voss JC, Rutledge JC. VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation. Journal of Lipid Research. 51: 1273-83. PMID 19965582 DOI: 10.1194/jlr.M000406  1
2009 Zhong N, Weisgraber KH. Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches. Current Alzheimer Research. 6: 415-8. PMID 19874264 DOI: 10.2174/156720509789207921  1
2009 Zhong N, Ramaswamy G, Weisgraber KH. Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. The Journal of Biological Chemistry. 284: 27273-80. PMID 19666463 DOI: 10.1074/jbc.M109.014464  1
2009 Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T. Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. Journal of Neurochemistry. 110: 1254-62. PMID 19549280 DOI: 10.1111/j.1471-4159.2009.06222.x  1
2009 Hatters DM, Voss JC, Budamagunta MS, Newhouse YN, Weisgraber KH. Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy. Journal of Molecular Biology. 386: 261-71. PMID 19124026 DOI: 10.1016/j.jmb.2008.12.040  1
2009 Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. Journal of Lipid Research. 50: S183-8. PMID 19106071 DOI: 10.1194/jlr.R800069-JLR200  1
2009 Zhong N, Weisgraber KH. Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure. The Journal of Biological Chemistry. 284: 6027-31. PMID 18948255 DOI: 10.1074/jbc.R800009200  1
2008 Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH. Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 179-92. PMID 18631967 DOI: 10.1016/j.jalz.2008.01.006  1
2008 Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, ... ... Weisgraber KH, et al. Genes contributing to prion pathogenesis. The Journal of General Virology. 89: 1777-88. PMID 18559949 DOI: 10.1099/vir.0.2008/001255-0  1
2007 Mahley RW, Huang Y, Weisgraber KH. Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease. Current Alzheimer Research. 4: 537-40. PMID 18220516 DOI: 10.2174/156720507783018334  1
2007 Zhang Y, Vasudevan S, Sojitrawala R, Zhao W, Cui C, Xu C, Fan D, Newhouse Y, Balestra R, Jerome WG, Weisgraber K, Li Q, Wang J. A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry. 46: 10722-32. PMID 17715945 DOI: 10.1021/bi700672v  1
2007 Peters-Libeu CA, Newhouse Y, Hall SC, Witkowska HE, Weisgraber KH. Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution. Journal of Lipid Research. 48: 1035-44. PMID 17308333 DOI: 10.1194/jlr.M600545-JLR200  1
2007 Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW. Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). The Pharmacogenomics Journal. 7: 10-28. PMID 16770341 DOI: 10.1038/sj.tpj.6500397  1
2006 Hatters DM, Zhong N, Rutenber E, Weisgraber KH. Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. Journal of Molecular Biology. 361: 932-44. PMID 16890957 DOI: 10.1016/j.jmb.2006.06.080  1
2006 Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB. Human prions and plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 103: 11312-7. PMID 16849426 DOI: 10.1073/pnas.0604021103  1
2006 Hatters DM, Peters-Libeu CA, Weisgraber KH. Apolipoprotein E structure: insights into function. Trends in Biochemical Sciences. 31: 445-54. PMID 16820298 DOI: 10.1016/j.tibs.2006.06.008  1
2006 Mahley RW, Huang Y, Weisgraber KH. Putting cholesterol in its place: apoE and reverse cholesterol transport. The Journal of Clinical Investigation. 116: 1226-9. PMID 16670767 DOI: 10.1172/JCI28632  1
2006 Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 5644-51. PMID 16567625 DOI: 10.1073/pnas.0600549103  1
2006 Braun NA, Mohler PJ, Weisgraber KH, Hasty AH, Linton MF, Yancey PG, Su YR, Fazio S, Swift LL. Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. Journal of Lipid Research. 47: 1176-86. PMID 16534141 DOI: 10.1194/jlr.M500503-JLR200  1
2006 Peters-Libeu CA, Newhouse Y, Hatters DM, Weisgraber KH. Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. The Journal of Biological Chemistry. 281: 1073-9. PMID 16278220 DOI: 10.1074/jbc.M510851200  1
2005 Peters-Libeu C, Newhouse Y, Krishnan P, Cheung K, Brooks E, Weisgraber K, Finkbeiner S. Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 1065-8. PMID 16511236 DOI: 10.1107/S1744309105036547  1
2005 Newhouse Y, Peters-Libeu C, Weisgraber KH. Crystallization and preliminary X-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 981-4. PMID 16511213 DOI: 10.1107/S1744309105032410  1
2005 Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. 102: 18700-5. PMID 16344478 DOI: 10.1073/pnas.0508693102  1
2005 Ramaswamy G, Xu Q, Huang Y, Weisgraber KH. Effect of domain interaction on apolipoprotein E levels in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10658-63. PMID 16291938 DOI: 10.1523/JNEUROSCI.1922-05.2005  1
2005 Hatters DM, Budamagunta MS, Voss JC, Weisgraber KH. Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms. The Journal of Biological Chemistry. 280: 34288-95. PMID 16076841 DOI: 10.1074/jbc.M506044200  1
2005 Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation. 111: 3457-64. PMID 15967843 DOI: 10.1161/CIRCULATIONAHA.104.523563  1
2005 Hatters DM, Peters-Libeu CA, Weisgraber KH. Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4. The Journal of Biological Chemistry. 280: 26477-82. PMID 15890642 DOI: 10.1074/jbc.M503910200  1
2005 Ruiz J, Kouiavskaia D, Migliorini M, Robinson S, Saenko EL, Gorlatova N, Li D, Lawrence D, Hyman BT, Weisgraber KH, Strickland DK. The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. Journal of Lipid Research. 46: 1721-31. PMID 15863833 DOI: 10.1194/jlr.M500114-JLR200  1
2005 Kasravi FB, Lee DH, Weisgraber K, Harris HW. Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS. Journal of Endotoxin Research. 11: 19-24. PMID 15826374 DOI: 10.1179/096805105225006731  1
2005 Hasty AH, Plummer MR, Weisgraber KH, Linton MF, Fazio S, Swift LL. The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. Journal of Lipid Research. 46: 1433-9. PMID 15805547 DOI: 10.1194/jlr.M400418-JLR200  1
2005 Sauer I, Dunay IR, Weisgraber K, Bienert M, Dathe M. An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells Biochemistry. 44: 2021-2029. PMID 15697227 DOI: 10.1021/bi048080x  1
2005 Zhao Y, Thorngate FE, Weisgraber KH, Williams DL, Parks JS. Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry. 44: 1013-25. PMID 15654758 DOI: 10.1021/bi0481489  1
2005 Raffai RL, Loeb SM, Weisgraber KH. Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 436-41. PMID 15591220 DOI: 10.1161/01.ATV.0000152613.83243.12  1
2004 Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 23: 189-204. PMID 15181247 DOI: 10.1385/JMN:23:3:189  1
2004 Farkas MH, Weisgraber KH, Shepherd VL, Linton MF, Fazio S, Swift LL. The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways. Journal of Lipid Research. 45: 1546-54. PMID 15145976 DOI: 10.1194/jlr.M400104-JLR200  1
2004 Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 279: 25511-6. PMID 15054100 DOI: 10.1074/jbc.M311256200  1
2003 Kasravi FB, Brecht WJ, Weisgraber KH, Harris HW. Induction of cytokine tolerance requires internalization of Chylomicron-Bound LPS into hepatocytes. The Journal of Surgical Research. 115: 303-9. PMID 14697298 DOI: 10.1016/S0022-4804(03)00197-5  1
2003 Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10966-71. PMID 12939405 DOI: 10.1073/pnas.1434398100  1
2003 Raffaï RL, McPherson R, Weisgraber KH, Innerarity TL, Rassart E, Bersot TP, Milne RW. Antibody phenotyping test for the human apolipoprotein E2 isoform. Clinical Chemistry. 49: 1524-6. PMID 12928236 DOI: 10.1373/49.9.1524  1
2003 Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC, Lund-Katz S. Effects of polymorphism on the lipid interaction of human apolipoprotein E. The Journal of Biological Chemistry. 278: 40723-9. PMID 12917433 DOI: 10.1074/jbc.M304814200  1
2003 Raffai RL, Weisgraber KH. Cholesterol: from heart attacks to Alzheimer's disease. Journal of Lipid Research. 44: 1423-30. PMID 12837845 DOI: 10.1194/jlr.R300007-JLR200  1
2003 Saito H, Dhanasekaran P, Nguyen D, Baldwin F, Weisgraber KH, Wehrli S, Phillips MC, Lund-Katz S. Characterization of the heparin binding sites in human apolipoprotein E. The Journal of Biological Chemistry. 278: 14782-7. PMID 12588864 DOI: 10.1074/jbc.M213207200  1
2003 Kasravi FB, Welch WJ, Peters-Lideu CA, Weisgraber KH, Harris HW. Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent. Shock (Augusta, Ga.). 19: 157-62. PMID 12578125  1
2003 Raffaï RL, Hasty AH, Wang Y, Mettler SE, Sanan DA, Linton MF, Fazio S, Weisgraber KH. Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance. The Journal of Biological Chemistry. 278: 11670-5. PMID 12551940 DOI: 10.1074/jbc.M212873200  1
2002 Morrow JA, Hatters DM, Lu B, Hochtl P, Oberg KA, Rupp B, Weisgraber KH. Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. The Journal of Biological Chemistry. 277: 50380-5. PMID 12393895 DOI: 10.1074/jbc.M204898200  1
2002 Segall ML, Dhanasekaran P, Baldwin F, Anantharamaiah GM, Weisgraber KH, Phillips MC, Lund-Katz S. Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. Journal of Lipid Research. 43: 1688-700. PMID 12364553 DOI: 10.1194/jlr.M200157-JLR200  1
2002 Zeleny M, Swertfeger DK, Weisgraber KH, Hui DY. Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry. 41: 11820-3. PMID 12269825 DOI: 10.1021/bi026202k  1
2002 Acharya P, Segall ML, Zaiou M, Morrow J, Weisgraber KH, Phillips MC, Lund-Katz S, Snow J. Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism. Biochimica Et Biophysica Acta. 1584: 9-19. PMID 12213488 DOI: 10.1016/S1388-1981(02)00263-9  1
2002 Jaworska-Wilczynska M, Wilczynski GM, Engel WK, Strickland DK, Weisgraber KH, Askanas V. Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle. Neurology. 58: 438-45. PMID 11839845  1
2002 Raffai RL, Weisgraber KH. Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. The Journal of Biological Chemistry. 277: 11064-8. PMID 11792702 DOI: 10.1074/jbc.M111222200  1
2001 Raffai RL, Dong LM, Farese RV, Weisgraber KH. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proceedings of the National Academy of Sciences of the United States of America. 98: 11587-91. PMID 11553788 DOI: 10.1073/pnas.201279298  1
2001 Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Lund-Katz S, Phillips MC. Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particles. The Journal of Biological Chemistry. 276: 40949-54. PMID 11533033 DOI: 10.1074/jbc.M106337200  1
2001 Libeu CP, Lund-Katz S, Phillips MC, Wehrli S, Hernáiz MJ, Capila I, Linhardt RJ, Raffaï RL, Newhouse YM, Zhou F, Weisgraber KH. New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E. The Journal of Biological Chemistry. 276: 39138-44. PMID 11500500 DOI: 10.1074/jbc.M104746200  1
2001 Lund-Katz S, Wehrli S, Zaiou M, Newhouse Y, Weisgraber KH, Phillips MC. Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE. Journal of Lipid Research. 42: 894-901. PMID 11369796  1
2001 Dong J, Peters-Libeu CA, Weisgraber KH, Segelke BW, Rupp B, Capila I, Hernáiz MJ, LeBrun LA, Linhardt RJ. Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry. 40: 2826-34. PMID 11258893 DOI: 10.1021/bi002417n  1
2000 Dong J, Balestra ME, Newhouse YM, Weisgraber KH. Human apolipoprotein E7:lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins. Journal of Lipid Research. 41: 1783-9. PMID 11060347  1
2000 Morrow JA, Segall ML, Lund-Katz S, Phillips MC, Knapp M, Rupp B, Weisgraber KH. Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. Biochemistry. 39: 11657-66. PMID 10995233 DOI: 10.1021/bi000099m  1
2000 Lund-Katz S, Zaiou M, Wehrli S, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC. Effects of lipid interaction on the lysine microenvironments in apolipoprotein E. The Journal of Biological Chemistry. 275: 34459-64. PMID 10921925 DOI: 10.1074/jbc.M005265200  1
2000 Zaiou M, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH, Segall ML, Phillips MC, Lund-Katz S. Apolipoprotein E;-low density lipoprotein receptor interaction. Influences of basic residue and amphipathic alpha-helix organization in the ligand. Journal of Lipid Research. 41: 1087-95. PMID 10884290  1
2000 Segelke BW, Forstner M, Knapp M, Trakhanov SD, Parkin S, Newhouse YM, Bellamy HD, Weisgraber KH, Rupp B. Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding. Protein Science : a Publication of the Protein Society. 9: 886-97. PMID 10850798 DOI: 10.1110/ps.9.5.886  1
2000 Lu B, Morrow JA, Weisgraber KH. Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid. The Journal of Biological Chemistry. 275: 20775-81. PMID 10801877 DOI: 10.1074/jbc.M003508200  1
2000 Klezovitch O, Formato M, Cherchi GM, Weisgraber KH, Scanu AM. Structural determinants in the C-terminal domain of apolipoprotein E mediating binding to the protein core of human aortic biglycan. The Journal of Biological Chemistry. 275: 18913-8. PMID 10751422 DOI: 10.1074/jbc.M909644199  1
2000 Raffaï R, Weisgraber KH, MacKenzie R, Rupp B, Rassart E, Hirama T, Innerarity TL, Milne R. Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling. The Journal of Biological Chemistry. 275: 7109-16. PMID 10702278 DOI: 10.1074/jbc.275.10.7109  1
2000 Morrow JA, Arnold KS, Dong J, Balestra ME, Innerarity TL, Weisgraber KH. Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor. The Journal of Biological Chemistry. 275: 2576-80. PMID 10644716 DOI: 10.1074/jbc.275.4.2576  1
1999 Forstner M, Peters-Libeu C, Contreras-Forrest E, Newhouse Y, Knapp M, Rupp B, Weisgraber KH. Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization. Protein Expression and Purification. 17: 267-72. PMID 10545275 DOI: 10.1006/prep.1999.1144  1
1999 Rozek A, Sparrow JT, Weisgraber KH, Cushley RJ. Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy. Biochemistry. 38: 14475-84. PMID 10545169 DOI: 10.1021/bi982966h  1
1999 Morrow JA, Arnold KS, Weisgraber KH. Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Protein Expression and Purification. 16: 224-30. PMID 10419818 DOI: 10.1006/prep.1999.1069  1
1999 Raffaï R, Vukmirica J, Weisgraber KH, Rassart E, Innerarity TL, Milne R. Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E. Protein Expression and Purification. 16: 84-90. PMID 10336864 DOI: 10.1006/prep.1999.1031  1
1999 Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW, Wieland H, Luley C. Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1306-15. PMID 10323784  1
1999 Trakhanov S, Parkin S, Raffaï R, Milne R, Newhouse YM, Weisgraber KH, Rupp B. Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A. Acta Crystallographica. Section D, Biological Crystallography. 55: 122-8. PMID 10089402 DOI: 10.1107/S090744499800938X  1
1999 Gillotte KL, Zaiou M, Lund-Katz S, Anantharamaiah GM, Holvoet P, Dhoest A, Palgunachari MN, Segrest JP, Weisgraber KH, Rothblat GH, Phillips MC. Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid. The Journal of Biological Chemistry. 274: 2021-8. PMID 9890960 DOI: 10.1074/jbc.274.4.2021  1
1998 Rozek A, Sparrow JT, Weisgraber KH, Cushley RJ. Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl sulfate. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 76: 267-75. PMID 9923695  1
1998 Pitas RE, Ji ZS, Weisgraber KH, Mahley RW. Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E. Biochemical Society Transactions. 26: 257-62. PMID 9649758  1
1998 Dong LM, Innerarity TL, Arnold KS, Newhouse YM, Weisgraber KH. The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity. Journal of Lipid Research. 39: 1173-80. PMID 9643348  1
1998 Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. The Journal of Biological Chemistry. 273: 1896-903. PMID 9442022 DOI: 10.1074/jbc.273.4.1896  1
1997 Grunfeld C, Doerrler W, Pang M, Jensen P, Weisgraber KH, Feingold KR. Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome. The Journal of Clinical Endocrinology and Metabolism. 82: 3734-40. PMID 9360533 DOI: 10.1210/jcem.82.11.4366  1
1997 Simmons T, Newhouse YM, Arnold KS, Innerarity TL, Weisgraber KH. Human low density lipoprotein receptor fragment. Successful refolding of a functionally active ligand-binding domain produced in Escherichia coli. The Journal of Biological Chemistry. 272: 25531-6. PMID 9325268 DOI: 10.1074/jbc.272.41.25531  1
1997 Meiner V, Tam C, Gunn MD, Dong LM, Weisgraber KH, Novak S, Myers HM, Erickson SK, Farese RV. Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. Journal of Lipid Research. 38: 1928-33. PMID 9323603  1
1997 Hussain MM, Goldberg IJ, Weisgraber KH, Mahley RW, Innerarity TL. Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 1407-13. PMID 9261274  1
1997 Gutman CR, Strittmatter WJ, Weisgraber KH, Matthew WD. Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6114-21. PMID 9236223  1
1996 Strittmatter WJ, Burke JR, DeSerrano VS, Huang DY, Matthew W, Saunders AM, Scott BL, Vance JM, Weisgraber KH, Roses AD. Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases. Cold Spring Harbor Symposia On Quantitative Biology. 61: 597-605. PMID 9246486  1
1996 Mirabella M, Alvarez RB, Engel WK, Weisgraber KH, Askanas V. Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies. Annals of Neurology. 40: 864-72. PMID 9007091 DOI: 10.1002/ana.410400608  1
1996 Weisgraber KH, Mahley RW. Human apolipoprotein E: the Alzheimer's disease connection. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 1485-94. PMID 8940294  1
1996 Montine TJ, Huang DY, Valentine WM, Amarnath V, Saunders A, Weisgraber KH, Graham DG, Strittmatter WJ. Crosslinking of apolipoprotein E by products of lipid peroxidation. Journal of Neuropathology and Experimental Neurology. 55: 202-10. PMID 8786379  1
1996 Askanas V, Engel WK, Mirabella M, Weisgraber KH, Saunders AM, Roses AD, McFerrin J. Apolipoprotein E alleles in sporadic inclusion-body myositis and hereditary inclusion-body myopathy. Annals of Neurology. 40: 264-5. PMID 8773613 DOI: 10.1002/ana.410400223  1
1996 Dong LM, Parkin S, Trakhanov SD, Rupp B, Simmons T, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH. Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nature Structural Biology. 3: 718-22. PMID 8756331 DOI: 10.1038/nsb0896-718  1
1996 Dong LM, Weisgraber KH. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. The Journal of Biological Chemistry. 271: 19053-7. PMID 8702576 DOI: 10.1074/jbc.271.32.19053  1
1996 Roses AD, Einstein G, Gilbert J, Goedert M, Han SH, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi PT. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Annals of the New York Academy of Sciences. 777: 146-57. PMID 8624078  1
1996 Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV. Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Experimental Neurology. 138: 252-60. PMID 8620924 DOI: 10.1006/exnr.1996.0064  1
1995 Evans KC, Berger EP, Cho CG, Weisgraber KH, Lansbury PT. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 92: 763-7. PMID 7846048 DOI: 10.1073/pnas.92.3.763  1
1995 Minnich A, Weisgraber KH, Newhouse Y, Dong LM, Fortin LJ, Tremblay M, Davignon J. Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins. Journal of Lipid Research. 36: 57-66. PMID 7706948  1
1995 Saxena U, Auerbach BJ, Ferguson E, Wölle J, Marcel YL, Weisgraber KH, Hegele RA, Bisgaier CL. Apolipoprotein B and E basic amino acid clusters influence low-density lipoprotein association with lipoprotein lipase anchored to the subendothelial matrix. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 1240-7. PMID 7627718  1
1995 Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neuroscience Letters. 192: 209-12. PMID 7566652 DOI: 10.1016/0304-3940(95)11649-H  1
1995 Huang DY, Weisgraber KH, Strittmatter WJ, Matthew WD. Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Experimental Neurology. 136: 251-7. PMID 7498414 DOI: 10.1006/exnr.1995.1101  1
1994 Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Experimental Neurology. 125: 163-71; discussion 1. PMID 8313935 DOI: 10.1006/exnr.1994.1019  1
1994 de Silva HV, Lauer SJ, Wang J, Simonet WS, Weisgraber KH, Mahley RW, Taylor JM. Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. The Journal of Biological Chemistry. 269: 2324-35. PMID 8294490  1
1994 Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science (New York, N.Y.). 264: 850-2. PMID 8171342  1
1994 Weisgraber KH. Apolipoprotein E: structure-function relationships. Advances in Protein Chemistry. 45: 249-302. PMID 8154371  1
1994 Swaney JB, Weisgraber KH. Effect of apolipoprotein C-I peptides on the apolipoprotein E content and receptor-binding properties of beta-migrating very low density lipoproteins. Journal of Lipid Research. 35: 134-42. PMID 8138714  1
1994 Weisgraber KH, Newhouse YM, McPherson A. Crystallization and preliminary X-ray analysis of human plasma apolipoprotein C-I. Journal of Molecular Biology. 236: 382-4. PMID 8107122 DOI: 10.1006/jmbi.1994.1146  1
1994 Han SH, Einstein G, Weisgraber KH, Strittmatter WJ, Saunders AM, Pericak-Vance M, Roses AD, Schmechel DE. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. Journal of Neuropathology and Experimental Neurology. 53: 535-44. PMID 8083695  1
1994 Schwarzman AL, Gregori L, Vitek MP, Lyubski S, Strittmatter WJ, Enghilde JJ, Bhasin R, Silverman J, Weisgraber KH, Coyle PK. Transthyretin sequesters amyloid beta protein and prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. 91: 8368-72. PMID 8078889  1
1994 Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. The Journal of Biological Chemistry. 269: 22358-65. PMID 8071364  1
1994 Weisgraber KH, Roses AD, Strittmatter WJ. The role of apolipoprotein E in the nervous system. Current Opinion in Lipidology. 5: 110-6. PMID 8044413  1
1994 Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. The Journal of Clinical Investigation. 94: 860-9. PMID 8040342 DOI: 10.1172/JCI117407  1
1994 Fazio S, Horie Y, Simonet WS, Weisgraber KH, Taylor JM, Rall SC. Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant. Journal of Lipid Research. 35: 408-16. PMID 8014576  1
1994 Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA. Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure (London, England : 1993). 2: 713-8. PMID 7994571 DOI: 10.1016/S0969-2126(00)00072-1  1
1994 Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 91: 11183-6. PMID 7972031  1
1994 Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience Letters. 182: 55-8. PMID 7891887 DOI: 10.1016/0304-3940(94)90204-6  1
1994 Weisgraber KH, Pitas RE, Mahley RW. Lipoproteins, neurobiology, and Alzheimer's disease: Structure and function of apolipoprotein E Current Opinion in Structural Biology. 4: 507-515.  1
1993 Schmidt EB, Illingworth DR, Bacon S, Russell SJ, Thatcher SR, Mahley RW, Weisgraber KH. Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100. Metabolism: Clinical and Experimental. 42: 137-9. PMID 8474308 DOI: 10.1016/0026-0495(93)90026-K  1
1993 Fazio S, Horie Y, Weisgraber KH, Havekes LM, Rall SC. Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma. Journal of Lipid Research. 34: 447-53. PMID 8468528  1
1993 Schmidt EB, Illingworth DR, Bacon S, Mahley RW, Weisgraber KH. Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100. Atherosclerosis. 98: 213-7. PMID 8457260 DOI: 10.1016/0021-9150(93)90130-M  1
1993 Bersot TP, Russell SJ, Thatcher SR, Pomernacki NK, Mahley RW, Weisgraber KH, Innerarity TL, Fox CS. A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder. Journal of Lipid Research. 34: 1149-54. PMID 8371062  1
1993 Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 8098-102. PMID 8367470  1
1993 de Silva HV, Lauer SJ, Mahley RW, Weisgraber KH, Taylor JM. Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice. Biochemical Society Transactions. 21: 483-7. PMID 8359515  1
1993 Westerlund JA, Weisgraber KH. Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. The Journal of Biological Chemistry. 268: 15745-50. PMID 8340399  1
1993 Lund-Katz S, Weisgraber KH, Mahley RW, Phillips MC. Conformation of apolipoprotein E in lipoproteins. The Journal of Biological Chemistry. 268: 23008-15. PMID 8226815  1
1993 Edwards WL, Bush SF, Matiingly TW, Weisgraber KH. Raman spectroscopic study of boundary lipid in 1,2-dipalmitoylphosphatidylcholine/apolipoprotein A-I recombinants Spectrochimica Acta - Part a Molecular Spectroscopy. 49: 2027-2038.  1
1992 Horie Y, Fazio S, Westerlund JR, Weisgraber KH, Rall SC. The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia. The Journal of Biological Chemistry. 267: 1962-8. PMID 1730728  1
1992 Thuren T, Weisgraber KH, Sisson P, Waite M. Role of apolipoprotein E in hepatic lipase catalyzed hydrolysis of phospholipid in high-density lipoproteins. Biochemistry. 31: 2332-8. PMID 1540589  1
1992 Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE. Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. Journal of Lipid Research. 33: 1677-88. PMID 1464751  1
1992 Illingworth DR, Vakar F, Mahley RW, Weisgraber KH. Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100. Lancet. 339: 598-600. PMID 1347103 DOI: 10.1016/0140-6736(92)90875-4  1
1991 Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science (New York, N.Y.). 252: 1817-22. PMID 2063194  1
1991 Weisgraber KH, Shinto LH. Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity. The Journal of Biological Chemistry. 266: 12029-34. PMID 2050696  1
1991 Mahley RW, Weisgraber KH, Innerarity TL, Rall SC. Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism. Jama. 265: 78-83. PMID 1845776 DOI: 10.1001/jama.1991.03460010078035  1
1991 Wardell MR, Rall SC, Schaefer EJ, Kane JP, Weisgraber KH. Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity. Journal of Lipid Research. 32: 521-8. PMID 1648586  1
1990 Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 10771-9. PMID 2355022  1
1990 Wardell MR, Rall SC, Brennan SO, Nye ER, George PM, Janus ED, Weisgraber KH. Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity. Journal of Lipid Research. 31: 535-43. PMID 2341812  1
1990 Weisgraber KH. Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. Journal of Lipid Research. 31: 1503-11. PMID 2280190  1
1990 Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, Grundy SM, Friedl W, Davignon J, McCarthy BJ. Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. Journal of Lipid Research. 31: 1337-49. PMID 2280177  1
1990 Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS. Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 22453-9. PMID 2266137  1
1990 Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E. Annals of the New York Academy of Sciences. 598: 37-48. PMID 2248450  1
1990 Simonet WS, Bucay N, Lauer SJ, Wirak DO, Stevens ME, Weisgraber KH, Pitas RE, Taylor JM. In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice. The Journal of Biological Chemistry. 265: 10809-12. PMID 2193025  1
1990 Simonet WS, Bucay N, Lauer SJ, Pitas RE, Weisgraber KH, Taylor JM. Downstream regulatory elements stimulate expression of the human apolipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice. Transactions of the Association of American Physicians. 103: 119-28. PMID 2132523  1
1990 Crook D, Weisgraber KH, Boyles JK, Mahley RW. Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets. Arteriosclerosis (Dallas, Tex.). 10: 633-47. PMID 2114868  1
1990 Crook D, Weisgraber KH, Rall SC, Mahley RW. Isolation and characterization of several plasma apolipoproteins of common marmoset monkey. Arteriosclerosis (Dallas, Tex.). 10: 625-32. PMID 2114867  1
1990 Mahley RW, Innerarity TL, Rall SC, Weisgraber KH, Taylor JM. Apolipoprotein E: Genetic variants provide insights into its structure and function Current Opinion in Lipidology. 1: 87-95.  1
1989 Weisgraber KH, Newhouse YM, Taylor JM, Tuan B, Nestruck AC, Davignon J, Mahley RW. Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes. Arteriosclerosis (Dallas, Tex.). 9: 50-7. PMID 2912421  1
1989 Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. The Journal of Clinical Investigation. 83: 2125-30. PMID 2723074 DOI: 10.1172/JCI114126  1
1989 Gong EL, Nichols AV, Weisgraber KH, Forte TM, Shore VG, Blanche PJ. Discoidal complexes containing apolipoprotein E and their transformation by lecithin-cholesterol acyltransferase. Biochimica Et Biophysica Acta. 1006: 317-28. PMID 2597674 DOI: 10.1016/0005-2760(89)90019-2  1
1989 Wardell MR, Weisgraber KH, Havekes LM, Rall SC. Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127. The Journal of Biological Chemistry. 264: 21205-10. PMID 2556398  1
1989 Rall SC, Newhouse YM, Clarke HR, Weisgraber KH, McCarthy BJ, Mahley RW, Bersot TP. Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant. The Journal of Clinical Investigation. 83: 1095-101. PMID 2539388 DOI: 10.1172/JCI113988  1
1989 Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. The Journal of Clinical Investigation. 83: 1015-31. PMID 2493483 DOI: 10.1172/JCI113943  1
1988 Aggerbeck LP, Wetterau JR, Weisgraber KH, Wu CS, Lindgren FT. Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains. The Journal of Biological Chemistry. 263: 6249-58. PMID 3360782  1
1988 Wetterau JR, Aggerbeck LP, Rall SC, Weisgraber KH. Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. The Journal of Biological Chemistry. 263: 6240-8. PMID 3360781  1
1988 Weisgraber KH, Newhouse YM, Mahley RW. Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes. Biochemical and Biophysical Research Communications. 157: 1212-7. PMID 3207421 DOI: 10.1016/S0006-291X(88)81003-9  1
1988 Weisgraber KH, Innerarity TL, Newhouse YM, Young SG, Arnold KS, Krauss RM, Vega GL, Grundy SM, Mahley RW. Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 85: 9758-62. PMID 3200853  1
1988 Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA. Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. Journal of Molecular Biology. 202: 179-81. PMID 3172212 DOI: 10.1016/0022-2836(88)90531-1  1
1988 Lalazar A, Weisgraber KH, Rall SC, Giladi H, Innerarity TL, Levanon AZ, Boyles JK, Amit B, Gorecki M, Mahley RW. Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions. The Journal of Biological Chemistry. 263: 3542-5. PMID 2831187  1
1988 Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, Shooter EM, Gebicke-Haerter PJ. Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. The Journal of Cell Biology. 107: 1207-13. PMID 2458361  1
1987 Innerarity TL, Young SG, Poksay KS, Mahley RW, Smith RS, Milne RW, Marcel YL, Weisgraber KH. Structural relationship of human apolipoprotein B48 to apolipoprotein B100. The Journal of Clinical Investigation. 80: 1794-8. PMID 3680528 DOI: 10.1172/JCI113273  1
1987 Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, Grundy SM. Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proceedings of the National Academy of Sciences of the United States of America. 84: 6919-23. PMID 3477815  1
1987 Weisgraber KH, Rall SC. Human apolipoprotein B-100 heparin-binding sites. The Journal of Biological Chemistry. 262: 11097-103. PMID 3301850  1
1987 Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. The Journal of Biological Chemistry. 262: 14352-60. PMID 3115992  1
1987 Gebicke-Haerter PJ, Darby JK, Shooter EM, Riccardi VM, Weisgraber KH, Boyles JK, Mahley RW. Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. Experimental Neurology. 95: 323-35. PMID 3100319 DOI: 10.1016/0014-4886(87)90142-7  1
1987 Innerarity TL, Weisgraber KH, Rall SC, Mahley RW. Functional domains of apolipoprotein E and apolipoprotein B. Acta Medica Scandinavica. Supplementum. 715: 51-9. PMID 3035881  1
1986 Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW. Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages. Arteriosclerosis (Dallas, Tex.). 6: 114-22. PMID 3942555  1
1986 Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. The Journal of Biological Chemistry. 261: 9858-64. PMID 3733697  1
1986 Weisgraber KH, Mahley RW. Characterization of apolipoprotein E-containing lipoproteins. Methods in Enzymology. 129: 145-66. PMID 3724537  1
1986 Rall SC, Weisgraber KH, Mahley RW. Isolation and characterization of apolipoprotein E. Methods in Enzymology. 128: 273-87. PMID 3724506  1
1986 Rall SC, Weisgraber KH, Mahley RW, Ehnholm C, Schamaun O, Olaisen B, Blomhoff JP, Teisberg P. Identification of homozygosity for a human apolipoprotein A-I variant. Journal of Lipid Research. 27: 436-41. PMID 3723016  1
1986 Mahley RW, Innerarity TL, Weisgraber KH, Rall SC, Hui DY, Lalazar A, Boyles JK, Taylor JM, Levy-Wilson B. Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions. Cold Spring Harbor Symposia On Quantitative Biology. 51: 821-8. PMID 3034497  1
1986 Bersot TP, Innerarity TL, Pitas RE, Rall SC, Weisgraber KH, Mahley RW. Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages. The Journal of Clinical Investigation. 77: 622-30. PMID 2935560 DOI: 10.1172/JCI112345  1
1986 Ignatius MJ, Gebicke-Härter PJ, Skene JH, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM. Expression of apolipoprotein E during nerve degeneration and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 83: 1125-9. PMID 2419900  1
1986 Weisgraber KH, Rall SC, Mahley RW, Milne RW, Marcel YL, Sparrow JT. Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3. The Journal of Biological Chemistry. 261: 2068-76. PMID 2418019  1
1985 Weisgraber KH, Newhouse YM, Seymour JL, Rall SC, Mahley RW. Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels. Analytical Biochemistry. 151: 455-61. PMID 4096384 DOI: 10.1016/0003-2697(85)90204-0  1
1985 Vogel T, Weisgraber KH, Zeevi MI, Ben-Artzi H, Levanon AZ, Rall SC, Innerarity TL, Hui DY, Taylor JM, Kanner D. Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E. Proceedings of the National Academy of Sciences of the United States of America. 82: 8696-700. PMID 3909150  1
1985 Mahley RW, Innerarity TL, Rall SC, Weisgraber KH. Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia. Annals of the New York Academy of Sciences. 454: 209-21. PMID 3000263  1
1985 Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Receptor interactions controlling lipoprotein metabolism. Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire. 63: 898-905. PMID 2998579 DOI: 10.1139/o85-111  1
1985 Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Apolipoprotein E: receptor binding properties. Advances in Experimental Medicine and Biology. 183: 159-71. PMID 2412412  1
1984 Utermann G, Weisgraber KH, Weber W, Mahley RW. Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis. Journal of Lipid Research. 25: 378-82. PMID 6726088  1
1984 Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL. Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia. Proceedings of the National Academy of Sciences of the United States of America. 81: 5566-70. PMID 6591204 DOI: 10.1073/pnas.81.17.5566  1
1984 Steinmetz A, Utermann G, Haas J, Menzel HJ, Rall SC, Weisgraber KH, Mahley RW. Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase. Agents and Actions. Supplements. 16: 217-24. PMID 6435410  1
1984 Rall SC, Weisgraber KH, Mahley RW, Ogawa Y, Fielding CJ, Utermann G, Haas J, Steinmetz A, Menzel HJ, Assmann G. Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. The Journal of Biological Chemistry. 259: 10063-70. PMID 6432779  1
1984 Innerarity TL, Weisgraber KH, Arnold KS, Rall SC, Mahley RW. Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. The Journal of Biological Chemistry. 259: 7261-7. PMID 6327714  1
1984 Weisgraber KH, Rall SC, Innerarity TL, Mahley RW, Kuusi T, Ehnholm C. A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1. The Journal of Clinical Investigation. 73: 1024-33. PMID 6323533 DOI: 10.1172/JCI111287  1
1984 Innerarity TL, Bersot TP, Arnold KS, Weisgraber KH, Davis PA, Forte TM, Mahley RW. Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma. Metabolism: Clinical and Experimental. 33: 186-95. PMID 6319954 DOI: 10.1016/0026-0495(84)90133-1  1
1984 Mahley RW, Innerarity TL, Rall SC, Weisgraber KH. Plasma lipoproteins: apolipoprotein structure and function. Journal of Lipid Research. 25: 1277-94. PMID 6099394  1
1984 Funke H, Boyles J, Weisgraber KH, Ludwig EH, Hui DY, Mahley RW. Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells. Arteriosclerosis (Dallas, Tex.). 4: 452-61. PMID 6089725  1
1984 Rall SC, Weisgraber KH, Mahley RW. Mutants of human apolipoprotein A-I deficient in lecithin:cholesterol acyltransferase (LCAT) activation Federation Proceedings. 43: no. 2329.  1
1983 Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR. Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I. The Journal of Biological Chemistry. 258: 2508-13. PMID 6401735  1
1983 Rall SC, Weisgraber KH, Innerarity TL, Bersot TP, Mahley RW, Blum CB. Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype. The Journal of Clinical Investigation. 72: 1288-97. PMID 6313758 DOI: 10.1172/JCI111085  1
1983 Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT. The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. The Journal of Biological Chemistry. 258: 12348-54. PMID 6313653  1
1983 Innerarity TL, Friedlander EJ, Rall SC, Weisgraber KH, Mahley RW. The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. The Journal of Biological Chemistry. 258: 12341-7. PMID 6313652  1
1983 Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia. The Journal of Clinical Investigation. 71: 1023-31. PMID 6300187  1
1982 Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. Journal of Lipid Research. 23: 911-4. PMID 7130859  1
1982 Rall SC, Weisgraber KH, Mahley RW. Human apolipoprotein E. The complete amino acid sequence. The Journal of Biological Chemistry. 257: 4171-8. PMID 7068630  1
1982 Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proceedings of the National Academy of Sciences of the United States of America. 79: 4696-700. PMID 6289314  1
1982 Weisgraber KH, Innerarity TL, Mahley RW. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. The Journal of Biological Chemistry. 257: 2518-21. PMID 6277903  1
1981 Weisgraber KH, Rall SC, Mahley RW. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. The Journal of Biological Chemistry. 256: 9077-83. PMID 7263700  1
1981 Mahley RW, Hui DY, Innerarity TL, Weisgraber KH. Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. The Journal of Clinical Investigation. 68: 1197-206. PMID 6271808  1
1980 Weisgraber KH, Mahley RW. Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography. Journal of Lipid Research. 21: 316-25. PMID 7381326  1
1980 Weisgraber KH, Bersot TP, Mahley RW, Franceschini G, Sirtori CR. A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins. The Journal of Clinical Investigation. 66: 901-7. PMID 6776144 DOI: 10.1172/JCI109957  1
1977 Fry DL, Mahley RW, Weisgraber KH, Oh SY. Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall. The American Journal of Physiology. 233: H66-79. PMID 879338  1
1977 Mahley RW, Innerarity TL, Weisgraber KH, Fry DL. Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro. The American Journal of Pathology. 87: 205-26. PMID 192082  1
Show low-probability matches.