Marcelo Rubinstein, Ph.D - Publications

Affiliations: 
Physiology and Molecular and Cellular Biology Universidad de Buenos Aires, Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina 

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Year Citation  Score
2019 Pisciottano F, Cinalli AR, Stopiello M, Castagna VC, Elgoyhen AB, Rubinstein M, Gómez-Casati ME, Franchini LF. Inner Ear Genes Underwent Positive Selection and Adaptation in the Mammalian Lineage. Molecular Biology and Evolution. PMID 31137036 DOI: 10.1093/molbev/msz077  0.8
2019 Orquera DP, Tavella MB, de Souza FSJ, Nasif S, Low MJ, Rubinstein M. The homeodomain transcription factor NKX2.1 is essential for the early specification of melanocortin neuron identity and activates expression in the developing hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30886014 DOI: 10.1523/JNEUROSCI.2924-18.2019  0.92
2019 Cromberg LE, Saez TMM, Otero MG, Tomasella E, Alloatti M, Damianich A, Devoto VP, Ferrario J, Gelman D, Rubinstein M, Falzone TL. Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors. Journal of Neurochemistry. PMID 30664247 DOI: 10.1111/jnc.14665  0.76
2017 Steyn FJ, Ngo ST, Chen VP, Bailey-Downs LC, Xie TY, Ghadami M, Brimijoin S, Freeman WM, Rubinstein M, Low MJ, Stout MB. 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell. PMID 29168299 DOI: 10.1111/acel.12703  0.92
2017 Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, et al. Lorcaserin improves glycemic control via a melanocortin neurocircuit. Molecular Metabolism. 6: 1092-1102. PMID 29031711 DOI: 10.1016/j.molmet.2017.07.004  0.92
2017 Rubinstein M, Low MJ. Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity. Febs Letters. PMID 28771698 DOI: 10.1002/1873-3468.12776  0.92
2016 Zhou Y, Rubinstein M, Low MJ, Kreek MJ. Hypothalamic-specific proopiomelanocortin-deficiency reduces alcohol drinking in male and female mice. Genes, Brain, and Behavior. PMID 27870313 DOI: 10.1111/gbb.12362  0.92
2016 Luque GM, Lopez-Vicchi F, Ornstein AM, Brie B, De Winne C, Fiore E, Perez Millan MI, Mazzolini G, Rubinstein M, Becu-Villalobos D. Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00200.2016. PMID 27802964 DOI: 10.1152/ajpendo.00200.2016  0.4
2016 Chhabra KH, Adams JM, Jones GL, Yamashita M, Schlapschy M, Skerra A, Rubinstein M, Low MJ. Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity. Molecular Metabolism. 5: 869-81. PMID 27689000 DOI: 10.1016/j.molmet.2016.07.012  0.92
2016 Orquera DP, Nasif S, Low MJ, Rubinstein M, de Souza FS. Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus. Developmental Biology. PMID 27212025 DOI: 10.1016/j.ydbio.2016.05.021  0.92
2016 Lemos JC, Friend DM, Kaplan AR, Shin JH, Rubinstein M, Kravitz AV, Alvarez VA. Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling. Neuron. 90: 824-838. PMID 27196975 DOI: 10.1016/j.neuron.2016.04.040  0.84
2016 Dobbs LK, Kaplan AR, Lemos JC, Matsui A, Rubinstein M, Alvarez VA. Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine. Neuron. PMID 27181061 DOI: 10.1016/j.neuron.2016.04.031  0.84
2016 Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, et al. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Molecular Metabolism. 5: 245-52. PMID 26977396 DOI: 10.1016/j.molmet.2016.01.005  0.92
2015 Chhabra KH, Adams JM, Fagel B, Lam DD, Qi N, Rubinstein M, Low MJ. Hypothalamic POMC-deficiency improves glucose tolerance despite insulin resistance by increasing glycosuria. Diabetes. PMID 26467632 DOI: 10.2337/db15-0804  0.92
2015 Nasif S, de Souza FS, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M. Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proceedings of the National Academy of Sciences of the United States of America. 112: E1861-70. PMID 25825735 DOI: 10.1073/pnas.1500672112  0.92
2015 Lam DD, de Souza FS, Nasif S, Yamashita M, López-Leal R, Otero-Corchon V, Meece K, Sampath H, Mercer AJ, Wardlaw SL, Rubinstein M, Low MJ. Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold. Plos Genetics. 11: e1004935. PMID 25671638 DOI: 10.1371/journal.pgen.1004935  0.84
2015 Lam DD, Attard CA, Mercer AJ, Myers MG, Rubinstein M, Low MJ. Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism. Endocrinology. 156: 1292-302. PMID 25594696 DOI: 10.1210/en.2014-1373  0.92
2015 Ramirez MC, Ornstein AM, Luque GM, Perez Millan MI, Garcia-Tornadu I, Rubinstein M, Becu-Villalobos D. Pituitary and brain dopamine D2 receptors regulate liver gene sexual dimorphism. Endocrinology. 156: 1040-51. PMID 25545383 DOI: 10.1210/en.2014-1714  0.92
2015 Rocchetti J, Isingrini E, Dal Bo G, Sagheby S, Menegaux A, Tronche F, Levesque D, Moquin L, Gratton A, Wong TP, Rubinstein M, Giros B. Presynaptic D2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus. Biological Psychiatry. 77: 513-25. PMID 24742619 DOI: 10.1016/j.biopsych.2014.03.013  0.92
2014 Burke LK, Doslikova B, D'Agostino G, Garfield AS, Farooq G, Burdakov D, Low MJ, Rubinstein M, Evans ML, Billups B, Heisler LK. 5-HT obesity medication efficacy via POMC activation is maintained during aging. Endocrinology. 155: 3732-8. PMID 25051442 DOI: 10.1210/en.2014-1223  0.92
2014 Perez Millan MI, Luque GM, Ramirez MC, Noain D, Ornstein AM, Rubinstein M, Becu-Villalobos D. Selective disruption of dopamine D2 receptors in pituitary lactotropes increases body weight and adiposity in female mice. Endocrinology. 155: 829-39. PMID 24424036 DOI: 10.1210/en.2013-1707  0.92
2014 Smorgonskiy A, Tajalli A, Rachidi F, Rubinstein M, Diendorfer G, Pichler H. Analysis of lightning events preceding upward flashes from Gaisberg and Säntis Towers 2014 International Conference On Lightning Protection, Iclp 2014. 1382-1385. DOI: 10.1109/ICLP.2014.6973346  0.01
2014 Recordon D, Rubinstein M, Stojilovi? M, Mora N, Lugrin G, Rachidi F, Rouiller L, Hirschi W, Sliman S. A comparator-based technique for identification of intentional electromagnetic interference attacks Ieee International Symposium On Electromagnetic Compatibility. 1257-1262. DOI: 10.1109/EMCEurope.2014.6931097  0.01
2013 Domené S, Bumaschny VF, de Souza FS, Franchini LF, Nasif S, Low MJ, Rubinstein M. Enhancer turnover and conserved regulatory function in vertebrate evolution. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130027. PMID 24218639 DOI: 10.1098/rstb.2013.0027  0.92
2013 Rubinstein M, de Souza FS. Evolution of transcriptional enhancers and animal diversity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130017. PMID 24218630 DOI: 10.1098/rstb.2013.0017  0.92
2013 Xu W, Jones M, Liu B, Zhu X, Johnson CB, Edwards AC, Kong L, Jeng EK, Han K, Marcus WD, Rubinstein MP, Rhode PR, Wong HC. Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma. Cancer Research. 73: 3075-86. PMID 23644531 DOI: 10.1158/0008-5472.CAN-12-2357  0.56
2013 Teitz T, Inoue M, Valentine MB, Zhu K, Rehg JE, Zhao W, Finkelstein D, Wang YD, Johnson MD, Calabrese C, Rubinstein M, Hakem R, Weiss WA, Lahti JM. Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis. Cancer Research. 73: 4086-97. PMID 23536557 DOI: 10.1158/0008-5472.CAN-12-2681  0.92
2013 Noaín D, Pérez-Millán MI, Bello EP, Luque GM, Casas Cordero R, Gelman DM, Peper M, Tornadu IG, Low MJ, Becú-Villalobos D, Rubinstein M. Central dopamine D2 receptors regulate growth-hormone-dependent body growth and pheromone signaling to conspecific males. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 5834-42. PMID 23536095 DOI: 10.1523/JNEUROSCI.5673-12.2013  0.92
2013 de Souza FS, Franchini LF, Rubinstein M. Exaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong? Molecular Biology and Evolution. 30: 1239-51. PMID 23486611 DOI: 10.1093/molbev/mst045  0.92
2013 Grady DL, Thanos PK, Corrada MM, Barnett JC, Ciobanu V, Shustarovich D, Napoli A, Moyzis AG, Grandy D, Rubinstein M, Wang GJ, Kawas CH, Chen C, Dong Q, Wang E, et al. DRD4 genotype predicts longevity in mouse and human. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 286-91. PMID 23283341 DOI: 10.1523/JNEUROSCI.3515-12.2013  0.92
2012 Bumaschny VF, Yamashita M, Casas-Cordero R, Otero-Corchón V, de Souza FS, Rubinstein M, Low MJ. Obesity-programmed mice are rescued by early genetic intervention. The Journal of Clinical Investigation. 122: 4203-12. PMID 23093774 DOI: 10.1172/JCI62543  0.92
2012 Franchini LF, de Souza FS, Low MJ, Rubinstein M. Positive selection of co-opted mobile genetic elements in a mammalian gene: If you can't beat them, join them. Mobile Genetic Elements. 2: 106-109. PMID 22934245 DOI: 10.4161/mge.20267  0.92
2012 González S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J, Lluís C, Franco R, McCormick PJ, Volkow ND, Rubinstein M, Floran B, Ferré S. Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain. Molecular Psychiatry. 17: 650-62. PMID 21844870 DOI: 10.1038/mp.2011.93  0.92
2011 Franchini LF, López-Leal R, Nasif S, Beati P, Gelman DM, Low MJ, de Souza FJ, Rubinstein M. Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons. Proceedings of the National Academy of Sciences of the United States of America. 108: 15270-5. PMID 21876128 DOI: 10.1073/pnas.1104997108  0.92
2011 Rubinstein M, Low MJ. The smoking gun in nicotine-induced anorexia. Cell Metabolism. 14: 145-7. PMID 21803282 DOI: 10.1016/j.cmet.2011.07.006  0.92
2011 Bello EP, Mateo Y, Gelman DM, Noaín D, Shin JH, Low MJ, Alvarez VA, Lovinger DM, Rubinstein M. Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nature Neuroscience. 14: 1033-8. PMID 21743470 DOI: 10.1038/nn.2862  0.92
2011 Lee AK, Smart JL, Rubinstein M, Low MJ, Tse A. Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes. Endocrinology. 152: 1901-10. PMID 21343252 DOI: 10.1210/en.2010-1066  0.92
2011 Franchini LF, López-Leal R, Nasif S, Beati P, Gelman DM, Low MJ, De Souza FJS, Rubinstein M. Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 37 (15270-15275)) Proceedings of the National Academy of Sciences of the United States of America. 108: 20850. DOI: 10.1073/pnas.1119060109  0.92
2010 Rubinstein MR, Cremaschi GA, Oliveri LM, Gerez EN, Wald MR, Genaro AM. Possible involvement of stress hormones and hyperglycaemia in chronic mild stress-induced impairment of immune functions in diabetic mice. Stress (Amsterdam, Netherlands). 13: 384-91. PMID 20666647 DOI: 10.3109/10253891003667888  0.92
2010 Michaelides M, Pascau J, Gispert JD, Delis F, Grandy DK, Wang GJ, Desco M, Rubinstein M, Volkow ND, Thanos PK. Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate. The European Journal of Neuroscience. 32: 668-76. PMID 20646063 DOI: 10.1111/j.1460-9568.2010.07319.x  0.92
2010 García-Tornadu I, Risso G, Perez-Millan MI, Noain D, Diaz-Torga G, Low MJ, Rubinstein M, Becu-Villalobos D. Neurotransmitter modulation of the GHRH-GH axis. Frontiers of Hormone Research. 38: 59-69. PMID 20616496 DOI: 10.1159/000318495  0.92
2010 García-Tornadú I, Ornstein AM, Chamson-Reig A, Wheeler MB, Hill DJ, Arany E, Rubinstein M, Becu-Villalobos D. Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance. Endocrinology. 151: 1441-50. PMID 20147524 DOI: 10.1210/en.2009-0996  0.92
2010 Thanos PK, Bermeo C, Rubinstein M, Suchland KL, Wang GJ, Grandy DK, Volkow ND. Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors. Journal of Psychopharmacology (Oxford, England). 24: 897-904. PMID 19282420 DOI: 10.1177/0269881109102613  0.92
2009 Nemirovsky SI, Avale ME, Brunner D, Rubinstein M. Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors. Synapse (New York, N.Y.). 63: 991-7. PMID 19598175 DOI: 10.1002/syn.20680  0.92
2009 Guo C, Qiu HY, Shi M, Huang Y, Johnson RL, Rubinstein M, Chen SD, Ding YQ. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons (Journal of Neuroscience (2008) (14097-14106)) Journal of Neuroscience. 29.  0.92
2008 Guo C, Qiu HY, Shi M, Huang Y, Johnson RL, Rubinstein M, Chen SD, Ding YQ. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14097-106. PMID 19109492 DOI: 10.1523/JNEUROSCI.3267-08.2008  0.92
2008 Da Ros VG, Maldera JA, Willis WD, Cohen DJ, Goulding EH, Gelman DM, Rubinstein M, Eddy EM, Cuasnicu PS. Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1). Developmental Biology. 320: 12-8. PMID 18571638 DOI: 10.1016/j.ydbio.2008.03.015  0.92
2008 Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, MacKenzie RG. Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology. 149: 3346-54. PMID 18403487 DOI: 10.1210/en.2007-0945  0.92
2008 Kelly MA, Low MJ, Rubinstein M, Phillips TJ. Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice. Genes, Brain, and Behavior. 7: 568-77. PMID 18363855 DOI: 10.1111/j.1601-183X.2008.00392.x  0.92
2007 Santangelo AM, de Souza FS, Franchini LF, Bumaschny VF, Low MJ, Rubinstein M. Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene. Plos Genetics. 3: 1813-26. PMID 17922573 DOI: 10.1371/journal.pgen.0030166  0.84
2007 Bumaschny VF, de Souza FS, López Leal RA, Santangelo AM, Baetscher M, Levi DH, Low MJ, Rubinstein M. Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence. Molecular Endocrinology (Baltimore, Md.). 21: 2738-49. PMID 17698954 DOI: 10.1210/me.2006-0557  0.84
2007 Wedemeyer C, Goutman JD, Avale ME, Franchini LF, Rubinstein M, Calvo DJ. Functional activation by central monoamines of human dopamine D(4) receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes. European Journal of Pharmacology. 562: 165-73. PMID 17350612 DOI: 10.1016/j.ejphar.2007.01.055  0.92
2006 Noaín D, Avale ME, Wedemeyer C, Calvo D, Peper M, Rubinstein M. Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. The European Journal of Neuroscience. 24: 2429-38. PMID 17100831 DOI: 10.1111/j.1460-9568.2006.05148.x  0.56
2006 García-Tornadú I, Rubinstein M, Gaylinn BD, Hill D, Arany E, Low MJ, Díaz-Torga G, Becu-Villalobos D. GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin. The Journal of Endocrinology. 190: 611-9. PMID 17003262 DOI: 10.1677/joe.1.06902  0.92
2006 Cristina C, García-Tornadú I, Díaz-Torga G, Rubinstein M, Low MJ, Becú-Villalobos D. Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma. Frontiers of Hormone Research. 35: 50-63. PMID 16809922 DOI: 10.1159/000094308  0.92
2005 Elmer GI, Pieper JO, Levy J, Rubinstein M, Low MJ, Grandy DK, Wise RA. Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice. Psychopharmacology. 182: 33-44. PMID 16136297 DOI: 10.1007/s00213-005-0051-2  0.92
2005 de Souza FS, Bumaschny VF, Low MJ, Rubinstein M. Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishes. Molecular Biology and Evolution. 22: 2417-27. PMID 16093565 DOI: 10.1093/molbev/msi236  0.84
2005 Thanos PK, Rivera SN, Weaver K, Grandy DK, Rubinstein M, Umegaki H, Wang GJ, Hitzemann R, Volkow ND. Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking. Life Sciences. 77: 130-9. PMID 15862598 DOI: 10.1016/j.lfs.2004.10.061  0.92
2005 Cristina C, Díaz-Torga G, Baldi A, Góngora A, Rubinstein M, Low MJ, Becú-Villalobos D. Increased pituitary vascular endothelial growth factor-a in dopaminergic D2 receptor knockout female mice. Endocrinology. 146: 2952-62. PMID 15817666 DOI: 10.1210/en.2004-1445  0.92
2005 de Souza FS, Santangelo AM, Bumaschny V, Avale ME, Smart JL, Low MJ, Rubinstein M. Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. Molecular and Cellular Biology. 25: 3076-86. PMID 15798195 DOI: 10.1128/MCB.25.8.3076-3086.2005  0.92
2004 Avale ME, Nemirovsky SI, Raisman-Vozari R, Rubinstein M. Elevated serotonin is involved in hyperactivity but not in the paradoxical effect of amphetamine in mice neonatally lesioned with 6-hydroxydopamine. Journal of Neuroscience Research. 78: 289-96. PMID 15378510 DOI: 10.1002/jnr.20245  0.92
2004 Overstreet LS, Hentges ST, Bumaschny VF, de Souza FS, Smart JL, Santangelo AM, Low MJ, Westbrook GL, Rubinstein M. A transgenic marker for newly born granule cells in dentate gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3251-9. PMID 15056704 DOI: 10.1523/JNEUROSCI.5173-03.2004  0.92
2004 Gan L, Falzone TL, Zhang K, Rubinstein M, Baldessarini RJ, Tarazi FI. Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice. Journal of Molecular Neuroscience : Mn. 22: 167-78. PMID 14997010 DOI: 10.1385/JMN:22:3:167  0.92
2004 Narayanan S, Lam H, Christian L, Levine MS, Grandy D, Rubinstein M, Maidment NT. Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation. Neuroscience. 124: 241-6. PMID 14960355 DOI: 10.1016/j.neuroscience.2003.11.011  0.92
2004 Avale ME, Falzone TL, Gelman DM, Low MJ, Grandy DK, Rubinstein M. The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder. Molecular Psychiatry. 9: 718-26. PMID 14699433 DOI: 10.1038/sj.mp.4001474  0.92
2004 Tomiyama K, McNamara FN, Clifford JJ, Kinsella A, Drago J, Fuchs S, Grandy DK, Low MJ, Rubinstein M, Tighe O, Croke DT, Koshikawa N, Waddington JL. Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout". Synapse (New York, N.Y.). 51: 71-81. PMID 14579426 DOI: 10.1002/syn.10284  0.92
2003 Franchini LF, Rubinstein M, Vivas L. Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking beta-endorphin. Neuroscience. 121: 875-81. PMID 14580937 DOI: 10.1016/S0306-4522(03)00485-8  0.92
2003 Gelman DM, Noaín D, Avale ME, Otero V, Low MJ, Rubinstein M. Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons. Genesis (New York, N.Y. : 2000). 36: 196-202. PMID 12929090 DOI: 10.1002/gene.10217  0.92
2003 Low MJ, Hayward MD, Appleyard SM, Rubinstein M. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Annals of the New York Academy of Sciences. 994: 192-201. PMID 12851316  0.92
2003 Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro J, Zigman JM, Cone RD, Elmquist JK. Central serotonin and melanocortin pathways regulating energy homeostasis. Annals of the New York Academy of Sciences. 994: 169-74. PMID 12851313  0.92
2003 Katz JL, Chausmer AL, Elmer GI, Rubinstein M, Low MJ, Grandy DK. Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice. Psychopharmacology. 170: 108-14. PMID 12783155 DOI: 10.1007/s00213-003-1513-z  0.92
2003 Appleyard SM, Hayward M, Young JI, Butler AA, Cone RD, Rubinstein M, Low MJ. A role for the endogenous opioid beta-endorphin in energy homeostasis. Endocrinology. 144: 1753-60. PMID 12697680 DOI: 10.1210/en.2002-221096  0.92
2003 Ibrahim N, Bosch MA, Smart JL, Qiu J, Rubinstein M, Rønnekleiv OK, Low MJ, Kelly MJ. Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology. 144: 1331-40. PMID 12639916 DOI: 10.1210/en.2002-221033  0.92
2002 Ensinck JW, Baskin DG, Vahl TP, Vogel RE, Laschansky EC, Francis BH, Hoffman RC, Krakover JD, Stamm MR, Low MJ, Rubinstein M, Otero-Corchon V, D'Alessio DA. Thrittene, Homologous with Somatostatin-28(1-13), Is a Novel Peptide in Mammalian Gut and Circulation. Endocrinology. 143: 2599-2609. PMID 28201530 DOI: 10.1210/endo.143.7.8904  0.92
2002 Refojo D, Kovalovsky D, Young JI, Rubinstein M, Holsboer F, Reul JM, Low MJ, Arzt E. Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice. Journal of Neuroimmunology. 131: 126-34. PMID 12458044 DOI: 10.1016/S0165-5728(02)00268-0  0.92
2002 Thanos PK, Taintor NB, Alexoff D, Vaska P, Logan J, Grandy DK, Fang Y, Lee JH, Fowler JS, Volkow ND, Rubinstein M. In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 43: 1570-7. PMID 12411561  0.6
2002 Chausmer AL, Elmer GI, Rubinstein M, Low MJ, Grandy DK, Katz JL. Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Psychopharmacology. 163: 54-61. PMID 12185400 DOI: 10.1007/s00213-002-1142-y  0.92
2002 Ramírez JL, Mouchantaf R, Kumar U, Otero Corchon V, Rubinstein M, Low MJ, Patel YC. Brain somatostatin receptors are up-regulated in somatostatin-deficient mice. Molecular Endocrinology (Baltimore, Md.). 16: 1951-63. PMID 12145348 DOI: 10.1210/me.2002-0068  0.92
2002 Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK. Activation of central melanocortin pathways by fenfluramine. Science (New York, N.Y.). 297: 609-11. PMID 12142539 DOI: 10.1126/science.1072327  0.92
2002 Li X, Bek M, Asico LD, Yang Z, Rubinstein M, Grandy DK, Goldstein DS, Eisner GM, Jose PA. [Disruption of the D(2) dopamine receptor produces adrenergic and endothelin B receptor-dependent hypertension]. Zhonghua Yi Xue Za Zhi. 82: 703-7. PMID 12133472  0.92
2002 Ensinck JW, Baskin DG, Vahl TP, Vogel RE, Laschansky EC, Francis BH, Hoffman RC, Krakover JD, Stamm MR, Low MJ, Rubinstein M, Otero-Corchon V, D'Alessio DA. Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation. Endocrinology. 143: 2599-609. PMID 12072392 DOI: 10.1210/endo.143.7.8904  0.92
2002 Elmer GI, Pieper JO, Rubinstein M, Low MJ, Grandy DK, Wise RA. Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: RC224. PMID 12006606  0.92
2002 Díaz-Torga G, Feierstein C, Libertun C, Gelman D, Kelly MA, Low MJ, Rubinstein M, Becú-Villalobos D. Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice. Endocrinology. 143: 1270-9. PMID 11897683 DOI: 10.1210/endo.143.4.8750  0.92
2002 Nir I, Harrison JM, Haque R, Low MJ, Grandy DK, Rubinstein M, Iuvone PM. Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2063-73. PMID 11896146  0.92
2002 Falzone TL, Gelman DM, Young JI, Grandy DK, Low MJ, Rubinstein M. Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear. The European Journal of Neuroscience. 15: 158-64. PMID 11860516 DOI: 10.1046/j.0953-816x.2001.01842.x  0.92
2002 Buckmaster PS, Otero-Corchón V, Rubinstein M, Low MJ. Heightened seizure severity in somatostatin knockout mice. Epilepsy Research. 48: 43-56. PMID 11823109 DOI: 10.1016/S0920-1211(01)00318-7  0.92
2001 Li XX, Bek M, Asico LD, Yang Z, Grandy DK, Goldstein DS, Rubinstein M, Eisner GM, Jose PA. Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice. Hypertension. 38: 303-8. PMID 11566895  0.92
2001 Clifford JJ, Kinsella A, Tighe O, Rubinstein M, Grandy DK, Low MJ, Croke DT, Waddington JL. Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: 527-36. PMID 11557166 DOI: 10.1016/S0893-133X(01)00246-9  0.92
2001 Low MJ, Otero-Corchon V, Parlow AF, Ramirez JL, Kumar U, Patel YC, Rubinstein M. Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. The Journal of Clinical Investigation. 107: 1571-80. PMID 11413165 DOI: 10.1172/JCI11941  0.92
2001 Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411: 480-4. PMID 11373681 DOI: 10.1038/35078085  0.92
2001 Rubinstein M, Cepeda C, Hurst RS, Flores-Hernandez J, Ariano MA, Falzone TL, Kozell LB, Meshul CK, Bunzow JR, Low MJ, Levine MS, Grandy DK. Dopamine D4 receptor-deficient mice display cortical hyperexcitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3756-63. PMID 11356863  0.92
2001 Dockstader CL, Rubinstein M, Grandy DK, Low MJ, van der Kooy D. The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice. The European Journal of Neuroscience. 13: 995-1001. PMID 11264672 DOI: 10.1046/j.1460-9568.2001.01455.x  0.92
2001 Chen JF, Moratalla R, Impagnatiello F, Grandy DK, Cuellar B, Rubinstein M, Beilstein MA, Hackett E, Fink JS, Low MJ, Ongini E, Schwarzschild MA. The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 1970-5. PMID 11172060 DOI: 10.1073/pnas.98.4.1970  0.92
2001 Khan ZU, Koulen P, Rubinstein M, Grandy DK, Goldman-Rakic PS. An astroglia-linked dopamine D2-receptor action in prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 98: 1964-9. PMID 11172059 DOI: 10.1073/pnas.98.4.1964  0.92
2001 Cepeda C, Hurst RS, Altemus KL, Flores-Hernández J, Calvert CR, Jokel ES, Grandy DK, Low MJ, Rubinstein M, Ariano MA, Levine MS. Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice. Journal of Neurophysiology. 85: 659-70. PMID 11160501  0.92
2000 Cunningham CL, Howard MA, Gill SJ, Rubinstein M, Low MJ, Grandy DK. Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacology, Biochemistry, and Behavior. 67: 693-9. PMID 11166059 DOI: 10.1016/S0091-3057(00)00414-7  0.92
2000 Mogil JS, Grisel JE, Hayward MD, Bales JR, Rubinstein M, Belknap JK, Low MJ. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience. 101: 709-17. PMID 11113319 DOI: 10.1016/S0306-4522(00)00422-X  0.92
2000 Risinger FO, Freeman PA, Rubinstein M, Low MJ, Grandy DK. Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology. 152: 343-50. PMID 11105945 DOI: 10.1007/s002130000548  0.92
2000 Tseng KY, Roubert C, Do L, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Gershanik OS, Murer MG, Giros B, Raisman-Vozari R. Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice. Brain Research. Molecular Brain Research. 80: 1-6. PMID 11039723 DOI: 10.1016/S0169-328X(00)00107-8  0.92
2000 Liu B, Novick D, Kim SH, Rubinstein M. Production of a biologically active human interleukin 18 requires its prior synthesis as PRO-IL-18. Cytokine. 12: 1519-25. PMID 11023667 DOI: 10.1006/cyto.2000.0749  0.56
2000 Murer MG, Dziewczapolski G, Salin P, Vila M, Tseng KY, Ruberg M, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Hirsch E, Raisman-Vozari R, Gershanik O. The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice. Neuroscience. 99: 643-50. PMID 10974427 DOI: 10.1016/S0306-4522(00)00223-2  0.92
2000 Zahniser NR, Simosky JK, Mayfield RD, Negri CA, Hanania T, Larson GA, Kelly MA, Grandy DK, Rubinstein M, Low MJ, Fredholm BB. Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5949-57. PMID 10934242  0.92
2000 Defagot MC, Falzone TL, Low MJ, Grandy DK, Rubinstein M, Antonelli MC. Quantitative analysis of the dopamine D4 receptor in the mouse brain. Journal of Neuroscience Research. 59: 202-8. PMID 10650878 DOI: 10.1002/(SICI)1097-4547(20000115)59:2<202::AID-JNR6>3.0.CO;2-5  0.92
1999 Menalled LB, Dziewczapolski G, Garcia MC, Rubinstein M, Gershanik OS. D3 receptor knockdown through antisense oligonucleotide administration supports its inhibitory role in locomotion. Neuroreport. 10: 3131-6. PMID 10574548  0.92
1999 Grisel JE, Mogil JS, Grahame NJ, Rubinstein M, Belknap JK, Crabbe JC, Low MJ. Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Research. 835: 62-7. PMID 10448196 DOI: 10.1016/S0006-8993(99)01384-0  0.92
1999 Ralph RJ, Varty GB, Kelly MA, Wang YM, Caron MG, Rubinstein M, Grandy DK, Low MJ, Geyer MA. The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4627-33. PMID 10341260  0.92
1999 Dickinson SD, Sabeti J, Larson GA, Giardina K, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Gerhardt GA, Zahniser NR. Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. Journal of Neurochemistry. 72: 148-56. PMID 9886065 DOI: 10.1046/j.1471-4159.1999.0720148.x  0.92
1998 Phillips TJ, Brown KJ, Burkhart-Kasch S, Wenger CD, Kelly MA, Rubinstein M, Grandy DK, Low MJ. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature Neuroscience. 1: 610-5. PMID 10196569 DOI: 10.1038/2843  0.92
1998 Low MJ, Kelly MA, Rubinstein M, Grandy DK. Single genes and complex phenotypes. Molecular Psychiatry. 3: 373-7. PMID 9774768  0.92
1998 Young JI, Otero V, Cerdán MG, Falzone TL, Chan EC, Low MJ, Rubinstein M. Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6631-40. PMID 9712635  0.92
1998 Dziewczapolski G, Menalled LB, García MC, Mora MA, Gershanik OS, Rubinstein M. Opposite roles of D1 and D5 dopamine receptors in locomotion revealed by selective antisense oligonucleotides. Neuroreport. 9: 1-5. PMID 9592037  0.92
1998 Kelly MA, Rubinstein M, Phillips TJ, Lessov CN, Burkhart-Kasch S, Zhang G, Bunzow JR, Fang Y, Gerhardt GA, Grandy DK, Low MJ. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3470-9. PMID 9547254  0.92
1998 Cerdán MG, Young JI, Zino E, Falzone TL, Otero V, Torres HN, Rubinstein M. Accurate spatial and temporal transgene expression driven by a 3.8-kilobase promoter of the bovine beta-casein gene in the lactating mouse mammary gland. Molecular Reproduction and Development. 49: 236-45. PMID 9491375 DOI: 10.1002/(SICI)1098-2795(199803)49:3<236::AID-MRD3>3.0.CO;2-P  0.92
1998 Low MJ, Kelly MA, Rubinstein M, Grandy DK. Single genes and complex phenotypes Molecular Psychiatry. 3: 375-377.  0.92
1998 Phillips TJ, Brown KJ, Burkhart-Kasch S, Wenger CD, Kelly MA, Rubinstein M, Grandy DK, Low MJ. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors Molecular Cell. 1: 610-615.  0.92
1997 Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougall JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, Grandy DK. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. 90: 991-1001. PMID 9323127 DOI: 10.1016/S0092-8674(00)80365-7  0.92
1996 Rubinstein M, Mogil JS, Japón M, Chan EC, Allen RG, Low MJ. Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 93: 3995-4000. PMID 8633004 DOI: 10.1073/pnas.93.9.3995  0.92
1994 Japón MA, Rubinstein M, Low MJ. In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 42: 1117-25. PMID 8027530  0.92
1993 Rubinstein M, Japón MA, Low MJ. Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker. Nucleic Acids Research. 21: 2613-7. PMID 8392702  0.92
1993 Rubinstein M, Mortrud M, Liu B, Low MJ. Rat and mouse proopiomelanocortin gene sequences target tissue-specific expression to the pituitary gland but not to the hypothalamus of transgenic mice. Neuroendocrinology. 58: 373-80. PMID 8284022 DOI: 10.1159/000126566  0.92
1993 Low MJ, Liu B, Hammer GD, Rubinstein M, Allen RG. Post-translational processing of proopiomelanocortin (POMC) in mouse pituitary melanotroph tumors induced by a POMC-simian virus 40 large T antigen transgene. The Journal of Biological Chemistry. 268: 24967-75. PMID 8227058  0.92
1992 Rubinstein M, Liu B, Goodman RH, Low MJ. Targeted expression of somatostatin in vasopressinergic magnocellular hypothalamic neurons of transgenic mice. Molecular and Cellular Neurosciences. 3: 152-61. PMID 19912855 DOI: 10.1016/1044-7431(92)90019-X  0.92
1992 Liu B, Hammer GD, Rubinstein M, Mortrud M, Low MJ. Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice. Molecular and Cellular Biology. 12: 3978-90. PMID 1508198  0.92
1990 Rubinstein M, Muschietti JP, Gershanik O, Flawia MM, Stefano FJ. Adaptive mechanisms of striatal D1 and D2 dopamine receptors in response to a prolonged reserpine treatment in mice. The Journal of Pharmacology and Experimental Therapeutics. 252: 810-6. PMID 2138223  0.92
1989 Rubinstein M, Schinder AF, Gershanik O, Stefano FJ. Positive interaction between alpha-1 adrenergic and dopamine-2 receptors in locomotor activity of normo and supersensitive mice. Life Sciences. 44: 337-46. PMID 2536881 DOI: 10.1016/0024-3205(89)90227-0  0.92
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