Rosario Moratalla - Publications

Cajal Institute, CSIC, Madrid 
Parkinson disease, drug abuse, dyskinesia

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Moratalla R, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  0.741
2020 Espadas I, Ortiz O, García-Sanz P, Sanz-Magro A, Alberquilla S, Solis O, Delgado-García JM, Gruart A, Moratalla R. Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse. Cerebral Cortex (New York, N.Y. : 1991). PMID 33264389 DOI: 10.1093/cercor/bhaa354  0.782
2020 García-Sanz P, M F G Aerts J, Moratalla R. The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33219714 DOI: 10.1002/mds.28396  0.776
2020 Pérez-Taboada I, Alberquilla S, Martín ED, Anand R, Vietti-Michelina S, Tebeka NN, Cantley J, Cragg SJ, Moratalla R, Vallejo M. Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32666590 DOI: 10.1002/Mds.28124  0.373
2020 Suarez LM, Solis O, Sanz-Magro A, Alberquilla S, Moratalla R. Dopamine D1 Receptors Regulate Spines in Striatal Direct-Pathway and Indirect-Pathway Neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32643147 DOI: 10.1002/Mds.28174  0.732
2020 Gómez-Benito M, Granado N, García-Sanz P, Michel A, Dumoulin M, Moratalla R. Modeling Parkinson's Disease With the Alpha-Synuclein Protein. Frontiers in Pharmacology. 11: 356. PMID 32390826 DOI: 10.3389/Fphar.2020.00356  0.77
2020 Espadas I, Keifman E, Palomo-Garo C, Burgaz S, García C, Fernández-Ruiz J, Moratalla R. Beneficial effects of the phytocannabinoid Δ-THCV in L-DOPA-induced dyskinesia in Parkinson's disease. Neurobiology of Disease. 104892. PMID 32387338 DOI: 10.1016/J.Nbd.2020.104892  0.437
2019 Solís O, García-Sanz P, Martín AB, Granado N, Sanz-Magro A, Podlesniy P, Trullas R, Murer MG, Maldonado R, Moratalla R. Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice. Addiction Biology. e12840. PMID 31833146 DOI: 10.1111/Adb.12840  0.811
2019 Alberquilla S, Gonzalez-Granillo A, Martin ED, Moratalla R. Dopamine regulates spine density in striatal projection neurons in a concentration-dependent manner. Neurobiology of Disease. 104666. PMID 31682992 DOI: 10.1016/J.Nbd.2019.104666  0.488
2019 Rodríguez-Traver E, Rodríguez C, Díaz-Guerra E, Arenas F, Araúzo-Bravo M, Orera M, Kulisevsky J, Moratalla R, Vicario C. Generation of an integration-free iPSC line, ICCSICi005-A, derived from a Parkinson's disease patient carrying the L444P mutation in the GBA1 gene. Stem Cell Research. 40: 101578. PMID 31539859 DOI: 10.1016/J.Scr.2019.101578  0.312
2019 Barroso-Chinea P, Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Salas-Hernandez J, Rodriguez-Nuñez J, Febles-Casquero A, Cruz-Muros I, Afonso-Oramas D, Abreu-Gonzalez P, Moratalla R, Millan MJ, Gonzalez-Hernandez T. DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis. Autophagy. PMID 31538542 DOI: 10.1080/15548627.2019.1668606  0.396
2019 Rodríguez-Traver E, Díaz-Guerra E, Rodríguez C, Fernández P, Arenas F, Araúzo-Bravo M, Orera M, Kulisevsky J, Moratalla R, Vicario C. A collection of integration-free iPSCs derived from Parkinson's disease patients carrying mutations in the GBA1 gene. Stem Cell Research. 38: 101482. PMID 31203165 DOI: 10.1016/J.Scr.2019.101482  0.322
2019 Keifman E, Ruiz de Diego I, Pafundo DE, Paz RM, Solís O, Murer MG, Moratalla R. Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L-DOPA in a mouse model of Parkinson's disease. British Journal of Pharmacology. PMID 30895594 DOI: 10.1111/Bph.14663  0.723
2019 Gomez G, Escande MV, Suarez LM, Rela L, Belforte JE, Moratalla R, Murer MG, Gershanik OS, Taravini IRE. Changes in Dendritic Spine Density and Inhibitory Perisomatic Connectivity onto Medium Spiny Neurons in L-Dopa-Induced Dyskinesia. Molecular Neurobiology. PMID 30746639 DOI: 10.1007/S12035-019-1515-4  0.449
2018 Ruiz-DeDiego I, Fasano S, Solís O, Garcia-Montes JR, Brea J, Loza MI, Brambilla R, Moratalla R. Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin. Scientific Reports. 8: 15381. PMID 30337665 DOI: 10.1038/S41598-018-33713-3  0.762
2018 García-Montes JR, Solís O, Enríquez-Traba J, Ruiz-DeDiego I, Drucker-Colín R, Moratalla R. Genetic Knockdown of mGluR5 in Striatal D1R-Containing Neurons Attenuates L-DOPA-Induced Dyskinesia in Aphakia Mice. Molecular Neurobiology. PMID 30259400 DOI: 10.1007/S12035-018-1356-6  0.794
2018 Granado N, Ares-Santos S, Tizabi Y, Moratalla R. Striatal Reinnervation Process after Acute Methamphetamine-Induced Dopaminergic Degeneration in Mice. Neurotoxicity Research. PMID 29934756 DOI: 10.1007/S12640-018-9925-Z  0.366
2018 Garrido-Gil P, Dominguez-Meijide A, Moratalla R, Guerra MJ, Labandeira-Garcia JL. Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly. Oncotarget. 9: 10834-10846. PMID 29541380 DOI: 10.18632/Oncotarget.24330  0.383
2018 Suarez LM, Alberquilla S, García-Montes JR, Moratalla R. Differential synaptic remodeling by dopamine in direct and indirect striatal projection neurons in Pitx3-/- mice, a genetic model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29483281 DOI: 10.1523/Jneurosci.3184-17.2018  0.819
2018 Solís O, Moratalla R. Dopamine receptors: homomeric and heteromeric complexes in L-DOPA-induced dyskinesia. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 29417335 DOI: 10.1007/S00702-018-1852-X  0.72
2018 García-Sanz P, Orgaz L, Fuentes JM, Vicario C, Moratalla R. Cholesterol and multilamellar bodies: Lyosomal dysfunction in GBA-Parkinson disease. Autophagy. 1-7. PMID 29368986 DOI: 10.1080/15548627.2018.1427396  0.762
2018 García-Sanz P, Moratalla R. The importance of cholesterol in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29315826 DOI: 10.1002/Mds.27251  0.758
2017 García-Sanz P, Orgaz L, Bueno-Gil G, Espadas I, Rodríguez-Traver E, Kulisevsky J, Gutierrez A, Dávila JC, González-Polo RA, Fuentes JM, Mir P, Vicario C, Moratalla R. N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28779532 DOI: 10.1002/Mds.27119  0.76
2017 García-Sanz P, Mirasierra M, Moratalla R, Vallejo M. Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy. Scientific Reports. 7: 389. PMID 28341857 DOI: 10.1038/S41598-017-00334-1  0.742
2017 Solís O, García-Montes JR, Garcia-Sanz P, Herranz AS, Asensio MJ, Kang G, Hiroi N, Moratalla R. Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice. Neurobiology of Disease. PMID 28315782 DOI: 10.1016/J.Nbd.2017.03.006  0.775
2017 F Hernández L, Castela I, Ruiz-DeDiego I, Obeso JA, Moratalla R. Striatal activation by optogenetics induces dyskinesias in the 6-hydroxydopamine rat model of Parkinson disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28256089 DOI: 10.1002/Mds.26947  0.412
2017 Moratalla R, Solís O, Suárez LM. Morphological Plasticity in the Striatum Associated With Dopamine Dysfunction Handbook of Behavioral Neuroscience. 24: 755-770. DOI: 10.1016/B978-0-12-802206-1.00037-4  0.72
2016 Suarez LM, Solis O, Aguado C, Lujan R, Moratalla R. L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia. Cerebral Cortex (New York, N.Y. : 1991). PMID 27613437 DOI: 10.1093/Cercor/Bhw263  0.697
2016 Solís O, García-Sanz P, Herranz AS, Asensio MJ, Moratalla R. L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum. Neurotoxicity Research. PMID 26966009 DOI: 10.1007/S12640-016-9612-X  0.791
2016 Mendieta L, Granado N, Aguilera J, Tizabi Y, Moratalla R. Fragment C domain of tetanus toxin mitigates methamphetamine neurotoxicity and its motor consequences in mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26945022 DOI: 10.1093/Ijnp/Pyw021  0.766
2015 Rodríguez-Traver E, Solís O, Díaz-Guerra E, Ortiz Ó, Vergaño-Vera E, Méndez-Gómez HR, García-Sanz P, Moratalla R, Vicario-Abejón C. Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells. Neurotoxicity Research. PMID 26678495 DOI: 10.1007/S12640-015-9586-0  0.798
2015 Solís O, Garcia-Montes JR, González-Granillo A, Xu M, Moratalla R. Dopamine D3 Receptor Modulates l-DOPA-Induced Dyskinesia by Targeting D1 Receptor-Mediated Striatal Signaling. Cerebral Cortex (New York, N.Y. : 1991). PMID 26483399 DOI: 10.1093/Cercor/Bhv231  0.819
2015 Moratalla R, Khairnar A, Simola N, Granado N, García-Montes JR, Porceddu PF, Tizabi Y, Costa G, Morelli M. Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms. Progress in Neurobiology. PMID 26455459 DOI: 10.1016/J.Pneurobio.2015.09.011  0.779
2015 Martín R, Bajo-Grañeras R, Moratalla R, Perea G, Araque A. GLIAL CELL SIGNALING. Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways. Science (New York, N.Y.). 349: 730-4. PMID 26273054 DOI: 10.1126/Science.Aaa7945  0.345
2015 Ruiz-DeDiego I, Naranjo JR, Hervé D, Moratalla R. Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 1039-49. PMID 25772224 DOI: 10.1002/Mds.26197  0.445
2015 Castro-Hernández J, Afonso-Oramas D, Cruz-Muros I, Salas-Hernández J, Barroso-Chinea P, Moratalla R, Millan MJ, González-Hernández T. Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake. Neurobiology of Disease. 74: 325-35. PMID 25511804 DOI: 10.1016/J.Nbd.2014.12.007  0.505
2015 Carmena A, Granado N, Ares-Santos S, Alberquilla S, Tizabi Y, Moratalla R. Methamphetamine-induced toxicity in indusium griseum of mice is associated with astro- and microgliosis. Neurotoxicity Research. 27: 209-16. PMID 25492248 DOI: 10.1007/S12640-014-9505-9  0.333
2015 Vergaño-Vera E, Díaz-Guerra E, Rodríguez-Traver E, Méndez-Gómez HR, Solís Ó, Pignatelli J, Pickel J, Lee SH, Moratalla R, Vicario-Abejón C. Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes. Developmental Neurobiology. 75: 823-41. PMID 25447275 DOI: 10.1002/Dneu.22251  0.707
2015 Solís O, Espadas I, Del-Bel EA, Moratalla R. Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice. Neurobiology of Disease. 73: 49-59. PMID 25281315 DOI: 10.1016/J.Nbd.2014.09.010  0.704
2015 Ruiz-DeDiego I, Mellstrom B, Vallejo M, Naranjo JR, Moratalla R. Activation of DREAM (downstream regulatory element antagonistic modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice. Biological Psychiatry. 77: 95-105. PMID 24857398 DOI: 10.1016/J.Biopsych.2014.03.023  0.394
2014 Heumann R, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Colín R, Garcia-Montes JR, Simola N, Morelli M. Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions. Journal of Neurochemistry. 130: 472-89. PMID 24773031 DOI: 10.1111/Jnc.12751  0.794
2014 Villar-Cheda B, Dominguez-Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira-Garcia JL. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiology of Aging. 35: 1726-38. PMID 24529758 DOI: 10.1016/J.Neurobiolaging.2014.01.017  0.456
2014 Granado N, Ares-Santos S, Moratalla R. D1 but not D4 dopamine receptors are critical for MDMA-induced neurotoxicity in mice. Neurotoxicity Research. 25: 100-9. PMID 24257898 DOI: 10.1007/S12640-013-9438-8  0.514
2014 Ares-Santos S, Granado N, Espadas I, Martinez-Murillo R, Moratalla R. Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1066-80. PMID 24169803 DOI: 10.1038/Npp.2013.307  0.481
2014 González-Aparicio R, Moratalla R. Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a mouse model of Parkinson´s disease. Neurobiology of Disease. 62: 416-25. PMID 24140894 DOI: 10.1016/J.Nbd.2013.10.008  0.459
2014 Urrutia A, Granado N, Gutierrez-Lopez MD, Moratalla R, O'Shea E, Colado MI. The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 235-46. PMID 24103647 DOI: 10.1017/S1461145713000850  0.403
2014 Suárez LM, Solís O, Caramés JM, Taravini IR, Solís JM, Murer MG, Moratalla R. L-DOPA treatment selectively restores spine density in dopamine receptor D2-expressing projection neurons in dyskinetic mice. Biological Psychiatry. 75: 711-22. PMID 23769604 DOI: 10.1016/J.Biopsych.2013.05.006  0.513
2013 Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF. Adenosine Aâ‚‚A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. Plos One. 8: e80902. PMID 24312250 DOI: 10.1371/Journal.Pone.0080902  0.814
2013 Peraile I, Granado N, Torres E, Gutiérrez-López MD, Moratalla R, Colado MI, O'Shea E. Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders. Psychopharmacology. 230: 125-35. PMID 23681166 DOI: 10.1007/S00213-013-3142-5  0.358
2013 Ares-Santos S, Granado N, Moratalla R. The role of dopamine receptors in the neurotoxicity of methamphetamine. Journal of Internal Medicine. 273: 437-53. PMID 23600399 DOI: 10.1111/Joim.12049  0.505
2013 Granado N, Ares-Santos S, Moratalla R. Methamphetamine and Parkinson's disease. Parkinson's Disease. 2013: 308052. PMID 23476887 DOI: 10.1155/2013/308052  0.463
2013 López-Jiménez A, Walter NA, Giné E, Santos Á, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA. A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption. Synapse (New York, N.Y.). 67: 280-9. PMID 23345080 DOI: 10.1002/Syn.21639  0.32
2012 Busceti CL, Bucci D, Molinaro G, Di Pietro P, Zangrandi L, Gradini R, Moratalla R, Battaglia G, Bruno V, Nicoletti F, Fornai F. Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons. Plos One. 7: e44025. PMID 23028485 DOI: 10.1371/Journal.Pone.0044025  0.456
2012 Espadas I, Darmopil S, Vergaño-Vera E, Ortiz O, Oliva I, Vicario-Abejón C, Martín ED, Moratalla R. L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: insights into regulation and function. Neurobiology of Disease. 48: 271-81. PMID 22820144 DOI: 10.1016/J.Nbd.2012.07.012  0.492
2012 Ares-Santos S, Granado N, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R. Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine. Neurobiology of Disease. 45: 810-20. PMID 22115942 DOI: 10.1016/J.Nbd.2011.11.005  0.448
2012 Madroñal N, Gruart A, Valverde O, Espadas I, Moratalla R, Delgado-García JM. Involvement of cannabinoid CB1 receptor in associative learning and in hippocampal CA3-CA1 synaptic plasticity. Cerebral Cortex (New York, N.Y. : 1991). 22: 550-66. PMID 21673070 DOI: 10.1093/Cercor/Bhr103  0.317
2011 Murer MG, Moratalla R. Striatal Signaling in L-DOPA-Induced Dyskinesia: Common Mechanisms with Drug Abuse and Long Term Memory Involving D1 Dopamine Receptor Stimulation. Frontiers in Neuroanatomy. 5: 51. PMID 21886608 DOI: 10.3389/Fnana.2011.00051  0.493
2011 Granado N, Lastres-Becker I, Ares-Santos S, Oliva I, Martin E, Cuadrado A, Moratalla R. Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia. 59: 1850-63. PMID 21882243 DOI: 10.1002/Glia.21229  0.438
2011 Suárez J, Ortíz O, Puente N, Bermúdez-Silva FJ, Blanco E, Fernández-Llebrez P, Grandes P, de Fonseca FR, Moratalla R. Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain. Neuroscience. 192: 112-31. PMID 21756982 DOI: 10.1016/J.Neuroscience.2011.06.062  0.329
2011 Granado N, Ares-Santos S, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiology of Disease. 42: 391-403. PMID 21303698 DOI: 10.1016/J.Nbd.2011.01.033  0.516
2011 Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R. Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. The Journal of Biological Chemistry. 286: 5846-54. PMID 21173143 DOI: 10.1074/Jbc.M110.161489  0.415
2011 Méndez-Gómez HR, Vergaño-Vera E, Abad JL, Bulfone A, Moratalla R, de Pablo F, Vicario-Abejón C. The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate. Molecular and Cellular Neurosciences. 46: 108-21. PMID 20807572 DOI: 10.1016/J.Mcn.2010.08.011  0.307
2010 Ortiz O, Delgado-García JM, Espadas I, Bahí A, Trullas R, Dreyer JL, Gruart A, Moratalla R. Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12288-300. PMID 20844125 DOI: 10.1523/Jneurosci.2655-10.2010  0.357
2010 Gramage E, Rossi L, Granado N, Moratalla R, Herradón G. Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum. Neuroscience. 170: 308-16. PMID 20620199 DOI: 10.1016/J.Neuroscience.2010.06.078  0.456
2010 Ramiro-Fuentes S, Ortiz O, Moratalla R, Fernandez-Espejo E. Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors. Neuroscience. 167: 205-15. PMID 20167255 DOI: 10.1016/J.Neuroscience.2010.02.019  0.345
2010 Granado N, Ares-Santos S, O'Shea E, Vicario-Abejón C, Colado MI, Moratalla R. Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine. Neurotoxicity Research. 18: 48-58. PMID 19760475 DOI: 10.1007/S12640-009-9106-1  0.457
2009 Darmopil S, Martín AB, De Diego IR, Ares S, Moratalla R. Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation. Biological Psychiatry. 66: 603-13. PMID 19520364 DOI: 10.1016/J.Biopsych.2009.04.025  0.486
2008 Granado N, O'Shea E, Bove J, Vila M, Colado MI, Moratalla R. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of Neurochemistry. 107: 1102-12. PMID 18823368 DOI: 10.1111/J.1471-4159.2008.05705.X  0.434
2008 Darmopil S, Muñetón-Gómez VC, de Ceballos ML, Bernson M, Moratalla R. Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA. The European Journal of Neuroscience. 27: 580-92. PMID 18279311 DOI: 10.1111/J.1460-9568.2008.06040.X  0.438
2008 Granado N, Escobedo I, O'Shea E, Colado I, Moratalla R. Early loss of dopaminergic terminals in striosomes after MDMA administration to mice. Synapse (New York, N.Y.). 62: 80-4. PMID 17960765 DOI: 10.1002/Syn.20466  0.459
2008 Martín AB, Fernandez-Espejo E, Ferrer B, Gorriti MA, Bilbao A, Navarro M, Rodriguez de Fonseca F, Moratalla R. Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1667-79. PMID 17957223 DOI: 10.1038/Sj.Npp.1301558  0.442
2008 Granado N, Ortiz O, Suárez LM, Martín ED, Ceña V, Solís JM, Moratalla R. D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus. Cerebral Cortex (New York, N.Y. : 1991). 18: 1-12. PMID 17395606 DOI: 10.1093/Cercor/Bhm026  0.381
2008 Moratalla R. Neurobiology of cocaine's addiction | Neurobiología de la cocaína Trastornos Adictivos. 10: 143-150. DOI: 10.1016/S1575-0973(08)76361-X  0.4
2007 Prieto-Lloret J, Donnelly DF, Rico AJ, Moratalla R, González C, Rigual RJ. Hypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D(2) receptors. Journal of Applied Physiology (Bethesda, Md. : 1985). 103: 1269-75. PMID 17673562 DOI: 10.1152/Japplphysiol.00391.2007  0.418
2007 Rodrigues TB, Granado N, Ortiz O, Cerdán S, Moratalla R. Metabolic interactions between glutamatergic and dopaminergic neurotransmitter systems are mediated through D(1) dopamine receptors. Journal of Neuroscience Research. 85: 3284-93. PMID 17455302 DOI: 10.1002/Jnr.21302  0.431
2007 Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Müller C, Woods AS, Hope BT, Ciruela F, Casadó V, Canela EI, Lluis C, Goldberg SR, Moratalla R, et al. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2249-59. PMID 17356572 DOI: 10.1038/Sj.Npp.1301375  0.341
2007 Ferrer B, Gorriti MA, Palomino A, Gornemann I, de Diego Y, Bermudez-Silva FJ, Bilbao A, Fernandez-Espejo E, Moratalla R, Navarro M, Rodríguez de Fonseca F. Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies. European Journal of Pharmacology. 559: 180-3. PMID 17291487 DOI: 10.1016/J.Ejphar.2007.01.009  0.437
2006 Bezard E, Gerlach I, Moratalla R, Gross CE, Jork R. 5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease. Neurobiology of Disease. 23: 77-86. PMID 16545572 DOI: 10.1016/J.Nbd.2006.02.003  0.45
2006 Bilbao A, Cippitelli A, Martín AB, Granado N, Ortiz O, Bezard E, Chen JF, Navarro M, Rodríguez de Fonseca F, Moratalla R. Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice. Psychopharmacology. 185: 160-8. PMID 16470403 DOI: 10.1007/S00213-005-0284-0  0.354
2006 Pavón N, Martín AB, Mendialdua A, Moratalla R. ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice. Biological Psychiatry. 59: 64-74. PMID 16139809 DOI: 10.1016/J.Biopsych.2005.05.044  0.468
2005 Saura J, Angulo E, Ejarque A, Casadó V, Tusell JM, Moratalla R, Chen JF, Schwarzschild MA, Lluis C, Franco R, Serratosa J. Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. Journal of Neurochemistry. 95: 919-29. PMID 16092928 DOI: 10.1111/J.1471-4159.2005.03395.X  0.332
2005 Johnson PL, Hollis JH, Moratalla R, Lightman SL, Lowry CA. Acute hypercarbic gas exposure reveals functionally distinct subpopulations of serotonergic neurons in rats. Journal of Psychopharmacology (Oxford, England). 19: 327-41. PMID 15982987 DOI: 10.1177/0269881105053281  0.315
2004 Grande C, Zhu H, Martin AB, Lee M, Ortiz O, Hiroi N, Moratalla R. Chronic treatment with atypical neuroleptics induces striosomal FosB/DeltaFosB expression in rats. Biological Psychiatry. 55: 457-63. PMID 15023572 DOI: 10.1016/J.Biopsych.2003.08.008  0.587
2003 Chen JF, Fredduzzi S, Bastia E, Yu L, Moratalla R, Ongini E, Schwarzschild MA. Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease. Neurology. 61: S74-81. PMID 14663016 DOI: 10.1212/01.Wnl.0000095218.26363.7B  0.486
2003 Rivera A, Trías S, Peñafiel A, Angel Narváez J, Díaz-Cabiale Z, Moratalla R, de la Calle A. Expression of D4 dopamine receptors in striatonigral and striatopallidal neurons in the rat striatum. Brain Research. 989: 35-41. PMID 14519509 DOI: 10.1016/S0006-8993(03)03328-6  0.446
2003 Centonze D, Grande C, Saulle E, Martin AB, Gubellini P, Pavón N, Pisani A, Bernardi G, Moratalla R, Calabresi P. Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8506-12. PMID 13679419  0.338
2003 Centonze D, Grande C, Usiello A, Gubellini P, Erbs E, Martin AB, Pisani A, Tognazzi N, Bernardi G, Moratalla R, Borrelli E, Calabresi P. Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6245-54. PMID 12867509 DOI: 10.1523/Jneurosci.23-15-06245.2003  0.433
2003 Julian MD, Martin AB, Cuellar B, Rodriguez De Fonseca F, Navarro M, Moratalla R, Garcia-Segura LM. Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience. 119: 309-18. PMID 12763090 DOI: 10.1016/S0306-4522(03)00070-8  0.427
2003 Chen JF, Moratalla R, Yu L, Martín AB, Xu K, Bastia E, Hackett E, Alberti I, Schwarzschild MA. Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1086-95. PMID 12700712 DOI: 10.1038/Sj.Npp.1300152  0.372
2003 Centonze D, Grande C, Saulle E, Martín AB, Gubellini P, Pavón N, Pisani A, Bernardi G, Moratalla R, Calabresi P. Distinct Roles of D1 and D5 Dopamine Receptors in Motor Activity and Striatal Synaptic Plasticity The Journal of Neuroscience. 23: 8506-8512. DOI: 10.1523/Jneurosci.23-24-08506.2003  0.449
2003 Rojas-Corrales M, Berrocoso E, Martin A, Grandy D, Micó J, Moratalla R. P.1.064 Differential response to imipramine in mice lacking D2 or D4 dopamine receptor gene European Neuropsychopharmacology. 13: S202. DOI: 10.1016/S0924-977X(03)91775-5  0.301
2002 Rivera A, Alberti I, Martín AB, Narváez JA, de la Calle A, Moratalla R. Molecular phenotype of rat striatal neurons expressing the dopamine D5 receptor subtype. The European Journal of Neuroscience. 16: 2049-58. PMID 12473072 DOI: 10.1046/J.1460-9568.2002.02280.X  0.455
2002 Saulle E, Centonze D, Martín AB, Moratalla R, Bernardi G, Calabresi P. Endogenous dopamine amplifies ischemic long-term potentiation via D1 receptors. Stroke; a Journal of Cerebral Circulation. 33: 2978-84. PMID 12468800 DOI: 10.1161/01.Str.0000038093.42512.0F  0.487
2002 Hiroi N, Martín AB, Grande C, Alberti I, Rivera A, Moratalla R. Molecular dissection of dopamine receptor signaling. Journal of Chemical Neuroanatomy. 23: 237-42. PMID 12048106 DOI: 10.1016/S0891-0618(02)00010-8  0.663
2002 Rivera A, Cuéllar B, Girón FJ, Grandy DK, de la Calle A, Moratalla R. Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum. Journal of Neurochemistry. 80: 219-29. PMID 11902112 DOI: 10.1046/J.0022-3042.2001.00702.X  0.403
2002 Fredduzzi S, Moratalla R, Monopoli A, Cuellar B, Xu K, Ongini E, Impagnatiello F, Schwarzschild MA, Chen JF. Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1054-62. PMID 11826134 DOI: 10.1523/Jneurosci.22-03-01054.2002  0.397
2001 Chen JF, Moratalla R, Impagnatiello F, Grandy DK, Cuellar B, Rubinstein M, Beilstein MA, Hackett E, Fink JS, Low MJ, Ongini E, Schwarzschild MA. The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 1970-5. PMID 11172060 DOI: 10.1073/Pnas.98.4.1970  0.316
2001 Frechilla D, Cobreros A, Saldise L, Moratalla R, Insausti R, Luquin M, Del Río J. Serotonin 5-HT(1A) receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys. Synapse (New York, N.Y.). 39: 288-96. PMID 11169778 DOI: 10.1002/1098-2396(20010315)39:4<288::Aid-Syn1011>3.0.Co;2-V  0.327
2000 Tan A, Moratalla R, Lyford GL, Worley P, Graybiel AM. The activity-regulated cytoskeletal-associated protein arc is expressed in different striosome-matrix patterns following exposure to amphetamine and cocaine. Journal of Neurochemistry. 74: 2074-8. PMID 10800951 DOI: 10.1046/J.1471-4159.2000.0742074.X  0.586
2000 Chen JF, Beilstein M, Xu YH, Turner TJ, Moratalla R, Standaert DG, Aloyo VJ, Fink JS, Schwarzschild MA. Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. Neuroscience. 97: 195-204. PMID 10771351 DOI: 10.1016/S0306-4522(99)00604-1  0.363
2000 Gardier AM, Moratalla R, Cuéllar B, Sacerdote M, Guibert B, Lebrec H, Graybiel AM. Interaction between the serotoninergic and dopaminergic systems in d-fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons. Journal of Neurochemistry. 74: 1363-73. PMID 10737591 DOI: 10.1046/J.1471-4159.2000.0741363.X  0.601
1997 Xu M, Koeltzow TE, Santiago GT, Moratalla R, Cooper DC, Hu XT, White NM, Graybiel AM, White FJ, Tonegawa S. Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 19: 837-48. PMID 9354330 DOI: 10.1016/S0896-6273(00)80965-4  0.681
1996 Moratalla R, Vallejo M, Elibol B, Graybiel AM. D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum. Neuroreport. 8: 1-5. PMID 9051741 DOI: 10.1097/00001756-199612200-00001  0.602
1996 Moratalla R, Xu M, Tonegawa S, Graybiel AM. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 14928-33. PMID 8962158 DOI: 10.1073/Pnas.93.25.14928  0.704
1996 Moratalla R, Elibol B, Vallejo M, Graybiel AM. Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron. 17: 147-56. PMID 8755486 DOI: 10.1016/S0896-6273(00)80288-3  0.552
1994 Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ, Tonegawa S. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell. 79: 945-55. PMID 8001143 DOI: 10.1016/0092-8674(94)90026-4  0.713
1994 Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 79: 729-42. PMID 7954836 DOI: 10.1016/0092-8674(94)90557-6  0.776
1993 Moratalla R, Vickers EA, Robertson HA, Cochran BH, Graybiel AM. Coordinate expression of c-fos and jun B is induced in the rat striatum by cocaine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 423-33. PMID 8426221 DOI: 10.1523/Jneurosci.13-02-00423.1993  0.568
1993 Graybiel AM, Moratalla R, Quinn B, DeLanney LE, Irwin I, Langston JW. Early-stage loss of dopamine uptake-site binding in MPTP-treated monkeys. Advances in Neurology. 60: 34-9. PMID 8420148  0.478
1992 Moratalla R, Robertson HA, Graybiel AM. Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 2609-22. PMID 1613551 DOI: 10.1523/Jneurosci.12-07-02609.1992  0.605
1992 Moratalla R, Quinn B, DeLanney LE, Irwin I, Langston JW, Graybiel AM. Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proceedings of the National Academy of Sciences of the United States of America. 89: 3859-63. PMID 1570304 DOI: 10.1073/Pnas.89.9.3859  0.591
1991 Robertson HA, Paul ML, Moratalla R, Graybiel AM. Expression of the immediate early gene c-fos in basal ganglia: induction by dopaminergic drugs. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 18: 380-3. PMID 1682022 DOI: 10.1017/S0317167100032480  0.612
1990 Graybiel AM, Moratalla R, Robertson HA. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proceedings of the National Academy of Sciences of the United States of America. 87: 6912-6. PMID 2118661 DOI: 10.1073/Pnas.87.17.6912  0.577
1989 Graybiel AM, Moratalla R. Dopamine uptake sites in the striatum are distributed differentially in striosome and matrix compartments. Proceedings of the National Academy of Sciences of the United States of America. 86: 9020-4. PMID 2813436 DOI: 10.1073/Pnas.86.22.9020  0.564
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