Selina Wray - Publications

Affiliations: 
UCL Institute of Neurology, London, England, United Kingdom 
Area:
Alzheimer's Disease, Dementia, Neurodegeneration

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, ... Wray S, et al. SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases. Nature Reviews. Neurology. PMID 31222062 DOI: 10.1038/s41582-019-0222-0  0.36
2019 Arber C, Toombs J, Lovejoy CC, Ryan NS, Paterson RW, Willumsen N, Gkanatsiou E, Portelius E, Blennow K, Heslegrave A, Schott JM, Hardy J, Lashley T, Fox NC, Zetterberg H, ... Wray S, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Molecular Psychiatry. PMID 30980041 DOI: 10.1038/s41380-019-0410-8  0.92
2019 Paonessa F, Evans LD, Solanki R, Larrieu D, Wray S, Hardy J, Jackson SP, Livesey FJ. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Reports. 26: 582-593.e5. PMID 30650353 DOI: 10.1016/j.celrep.2018.12.085  0.92
2018 Mamais A, Manzoni C, Nazish I, Arber C, Sonustun B, Wray S, Warner TT, Cookson MR, Lewis PA, Bandopadhyay R. Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology. Brain Research. PMID 30055128 DOI: 10.1016/j.brainres.2018.07.023  0.48
2018 Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JDH. A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathologica Communications. 6: 37. PMID 29730992 DOI: 10.1186/s40478-018-0539-8  1
2018 Ritchie L, Tate R, Chamberlain LH, Robertson G, Zagnoni M, Sposito T, Wray S, Wright JA, Bryant CE, Gay NJ, Bushell TJ. Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons. Neuropharmacology. PMID 29505789 DOI: 10.1016/j.neuropharm.2018.02.025  0.48
2017 Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, ... ... Wray S, et al. G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. Embo Molecular Medicine. PMID 29113975 DOI: 10.15252/emmm.201707850  0.52
2017 Arber C, Angelova PR, Wiethoff S, Tsuchiya Y, Mazzacuva F, Preza E, Bhatia KP, Mills K, Gout I, Abramov AY, Hardy J, Duce JA, Houlden H, Wray S. iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease. Plos One. 12: e0184104. PMID 28863176 DOI: 10.1371/journal.pone.0184104  0.92
2017 Hall CE, Yao Z, Choi M, Tyzack GE, Serio A, Luisier R, Harley J, Preza E, Arber C, Crisp SJ, Watson PMD, Kullmann DM, Abramov AY, Wray S, Burley R, et al. Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS. Cell Reports. 19: 1739-1749. PMID 28564594 DOI: 10.1016/j.celrep.2017.05.024  0.52
2017 Ludtmann MH, Arber C, Bartolome F, de Vicente M, Preza E, Carro E, Houlden H, Gandhi S, Wray S, Abramov AY. Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. The Journal of Biological Chemistry. PMID 28360103 DOI: 10.1074/jbc.M116.762898  0.52
2017 Esteras N, Rohrer JD, Hardy J, Wray S, Abramov AY. Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration. Redox Biology. 12: 410-422. PMID 28319892 DOI: 10.1016/j.redox.2017.03.008  0.92
2017 Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, et al. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron. PMID 28238547 DOI: 10.1016/j.neuron.2017.02.001  0.92
2016 Preza E, Hardy J, Warner T, Wray S. Induced pluripotent stem cell models of frontotemporal dementia. Neuropathology and Applied Neurobiology. PMID 27291591 DOI: 10.1111/nan.12334  0.92
2015 Wray S, Fox NC. Stem cell therapy for Alzheimer's disease: hope or hype? The Lancet. Neurology. PMID 26704440 DOI: 10.1016/S1474-4422(15)00382-8  1
2015 Sposito T, Preza E, Mahoney CJ, Setó-Salvia N, Ryan NS, Morris HR, Arber C, Devine MJ, Houlden H, Warner TT, Bushell TJ, Zagnoni M, Kunath T, Livesey FJ, Fox NC, ... ... Wray S, et al. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT. Human Molecular Genetics. PMID 26136155 DOI: 10.1093/hmg/ddv246  1
2015 Wiethoff S, Arber C, Li A, Wray S, Houlden H, Patani R. Using human induced pluripotent stem cells (hiPSC) to model cerebellar disease: Hope and hype. Journal of Neurogenetics. 1-25. PMID 25985846 DOI: 10.3109/01677063.2015.1053478  1
2015 Arber CE, Li A, Houlden H, Wray S. Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories. Neuropathology and Applied Neurobiology. PMID 25870938 DOI: 10.1111/nan.12242  1
2015 Rohrer JD, Isaacs AM, Mizielinska S, Mead S, Lashley T, Wray S, Sidle K, Fratta P, Orrell RW, Hardy J, Holton J, Revesz T, Rossor MN, Warren JD. C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis. The Lancet. Neurology. 14: 291-301. PMID 25638642 DOI: 10.1016/S1474-4422(14)70233-9  1
2015 Fratta P, Polke JM, Newcombe J, Mizielinska S, Lashley T, Poulter M, Beck J, Preza E, Devoy A, Sidle K, Howard R, Malaspina A, Orrell RW, Clarke J, Lu CH, ... ... Wray S, et al. Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion. Neurobiology of Aging. 36: 546.e1-7. PMID 25179228 DOI: 10.1016/j.neurobiolaging.2014.07.037  1
2014 Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP, Noble W. Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease. Aging Cell. 13: 49-59. PMID 23919677 DOI: 10.1111/acel.12148  1
2014 Torrance E, Robertson G, Wray S, Hardy J, Bushell T, Zagnoni M. A microfluidics platform for human tau mutation neurons 18th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2014. 898-900.  1
2013 Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, et al. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nature Neuroscience. 16: 1257-65. PMID 23933751 DOI: 10.1038/nn.3489  1
2013 Bartolome F, Wu HC, Burchell VS, Preza E, Wray S, Mahoney CJ, Fox NC, Calvo A, Canosa A, Moglia C, Mandrioli J, Chiò A, Orrell RW, Houlden H, Hardy J, et al. Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels. Neuron. 78: 57-64. PMID 23498975 DOI: 10.1016/j.neuron.2013.02.028  1
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/journal.pone.0043099  1
2012 Fawcett KA, Murphy SM, Polke JM, Wray S, Burchell VS, Manji H, Quinlivan RM, Zdebik AA, Reilly MM, Houlden H. Comprehensive analysis of the TRPV4 gene in a large series of inherited neuropathies and controls. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 1204-9. PMID 22851605 DOI: 10.1136/jnnp-2012-303055  1
2012 Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, Smith C, Luk C, Gibbs JR, Dillman A, Hernandez DG, Arepalli S, Singleton AB, Cookson MR, Pittman AM, de Silva R, et al. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Human Molecular Genetics. 21: 4094-103. PMID 22723018 DOI: 10.1093/hmg/dds238  1
2012 Crehan H, Holton P, Wray S, Pocock J, Guerreiro R, Hardy J. Complement receptor 1 (CR1) and Alzheimer's disease. Immunobiology. 217: 244-50. PMID 21840620 DOI: 10.1016/j.imbio.2011.07.017  1
2011 Ahmed Z, Doherty KM, Silveira-Moriyama L, Bandopadhyay R, Lashley T, Mamais A, Hondhamuni G, Wray S, Newcombe J, O'Sullivan SS, Wroe S, de Silva R, Holton JL, Lees AJ, Revesz T. Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies. Acta Neuropathologica. 122: 415-28. PMID 21773886 DOI: 10.1007/s00401-011-0857-4  1
2011 Hardy J, Guerreiro R, Wray S, Ferrari R, Momeni P. The genetics of Alzheimer's disease and other tauopathies Journal of Alzheimer's Disease. 23: S33-S39. DOI: 10.3233/JAD-2011-001433  1
2010 Wray S, Lewis PA. A tangled web - tau and sporadic Parkinson's disease. Frontiers in Psychiatry. 1: 150. PMID 21423457 DOI: 10.3389/fpsyt.2010.00150  1
2010 Hanger DP, Wray S. Tau cleavage and tau aggregation in neurodegenerative disease. Biochemical Society Transactions. 38: 1016-20. PMID 20658996 DOI: 10.1042/BST0381016  1
2010 Wray S, Hardy J. All MAPT out?: Well-travelled pathways into neurodegeneration Biochemist. 32: 14-17.  1
2009 Wray S, Noble W. Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9665-7. PMID 19657019 DOI: 10.1523/JNEUROSCI.2234-09.2009  1
2008 Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM, Hanger DP, Anderton BH. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. The Journal of Biological Chemistry. 283: 18177-86. PMID 18467332 DOI: 10.1074/jbc.M709715200  1
2008 Wray S, Saxton M, Anderton BH, Hanger DP. Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats. Journal of Neurochemistry. 105: 2343-52. PMID 18315566 DOI: 10.1111/j.1471-4159.2008.05321.x  1
2007 Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH. Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. The Journal of Biological Chemistry. 282: 23645-54. PMID 17562708 DOI: 10.1074/jbc.M703269200  1
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