Charles Vernon Mobbs, PhD - Publications

Neuroscience, Geriatrics, Endocrinology, Diabetes Icahn School of Medicine at Mount Sinai, New York, NY, United States 
glucose, aging, diabetes, metabolism

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Year Citation  Score
2018 Marcellino BK, Ekasumara N, Mobbs CV. Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49. Current Neurobiology. 9: 1-7. PMID 30820135  0.695
2018 Mobbs CV. Glucose-Induced Transcriptional Hysteresis: Role in Obesity, Metabolic Memory, Diabetes, and Aging. Frontiers in Endocrinology. 9: 232. PMID 29892261 DOI: 10.3389/Fendo.2018.00232  0.409
2017 Michaelides M, Miller ML, DiNieri JA, Gomez JL, Schwartz E, Egervari G, Wang GJ, Mobbs CV, Volkow ND, Hurd YL. Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28580946 DOI: 10.1038/Npp.2017.112  0.686
2016 Moreno CL, Mobbs CV. Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet. Molecular and Cellular Endocrinology. PMID 27884781 DOI: 10.1016/J.Mce.2016.11.013  0.326
2016 Moreno CL, Yang L, Dacks PA, Isoda F, Deursen JM, Mobbs CV. Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates. Plos One. 11: e0166381. PMID 27832201 DOI: 10.1371/Journal.Pone.0166381  0.751
2016 Devarakonda K, Mobbs CV. Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced reward. Molecular and Cellular Endocrinology. PMID 27637346 DOI: 10.1016/J.Mce.2016.09.012  0.349
2016 Mobbs CV. Orphaned No More? Glucose-Sensing Hypothalamic Neurons Control Insulin Secretion. Diabetes. 65: 2473-5. PMID 27555573 DOI: 10.2337/Dbi16-0027  0.393
2015 Moreno CL, Ehrlich ME, Mobbs CV. Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT. Neurobiology of Disease. 85: 25-34. PMID 26485309 DOI: 10.1016/J.Nbd.2015.09.012  0.366
2013 Mobbs CV, Moreno CL, Poplawski M. Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus. Trends in Endocrinology and Metabolism: Tem. 24: 488-94. PMID 23791973 DOI: 10.1016/J.Tem.2013.05.007  0.403
2013 Kim ES, Isoda F, Kurland I, Mobbs CV. Glucose-induced metabolic memory in Schwann cells: prevention by PPAR agonists. Endocrinology. 154: 3054-66. PMID 23709088 DOI: 10.1210/En.2013-1097  0.548
2013 Mobbs CV, Mastaitis J, Isoda F, Poplawski M. Treatment of diabetes and diabetic complications with a ketogenic diet. Journal of Child Neurology. 28: 1009-14. PMID 23680948 DOI: 10.1177/0883073813487596  0.336
2013 Mobbs CV, Moreno C. Hypothalamic EphA5 facilitates counterregulatory responses: possible role for bidirectional signaling leading to bistability that enhances responsiveness to hypoglycemia. Diabetes. 62: 1014-6. PMID 23520275 DOI: 10.2337/Db12-1735  0.336
2013 Moreno C, Yang L, Dacks P, Isoda F, Poplawski M, Mobbs CV. Regulation of peripheral metabolism by substrate partitioning in the brain. Endocrinology and Metabolism Clinics of North America. 42: 67-80. PMID 23391240 DOI: 10.1016/J.Ecl.2012.11.007  0.72
2013 Dacks PA, Moreno CL, Kim ES, Marcellino BK, Mobbs CV. Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Frontiers in Neuroendocrinology. 34: 95-106. PMID 23262258 DOI: 10.1016/J.Yfrne.2012.12.001  0.768
2012 Schwartz E, Mobbs CV. Hypothalamic BDNF and obesity: found in translation. Nature Medicine. 18: 496-7. PMID 22481407 DOI: 10.1038/Nm.2716  0.68
2012 Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin B, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. American Journal of Physiology. Endocrinology and Metabolism. 302: E987-91. PMID 22318949 DOI: 10.1152/Ajpendo.00474.2011  0.636
2012 Mobbs CV, Moreno CL, Kim ES, Ekasumara N, Marcellino BK. Neuroprotection by dietary restriction and the PPAR transcription complex Translational Neuroscience. 3: 234-241. DOI: 10.2478/S13380-012-0035-8  0.731
2011 Poritsanos NJ, Lew PS, Fischer J, Mobbs CV, Nagy JI, Wong D, Rüther U, Mizuno TM. Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice. Nutrition & Diabetes. 1: e19. PMID 23154321 DOI: 10.1038/Nutd.2011.15  0.449
2011 Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M, Mobbs C. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. Plos One. 6: e27762. PMID 22114686 DOI: 10.1371/Journal.Pone.0027762  0.656
2011 Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, ... Mobbs CV, et al. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine. 17: 1121-7. PMID 21873987 DOI: 10.1038/Nm.2421  0.572
2011 Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV. Reversal of diabetic nephropathy by a ketogenic diet. Plos One. 6: e18604. PMID 21533091 DOI: 10.1371/Journal.Pone.0018604  0.332
2011 Poplawski MM, Mastaitis JW, Mobbs CV. Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: role of metabolic reprogramming in counterregulatory failure. Diabetes. 60: 39-46. PMID 20811039 DOI: 10.2337/Db10-0326  0.367
2011 Diano S, Liu Z, Jeong JK, Dietrich MO, Ruan H, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, ... Mobbs CV, et al. Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity Nature Medicine. 17: 1320-1320. DOI: 10.1038/Nm1011-1320A  0.477
2010 Poplawski MM, Mastaitis JW, Yang XJ, Mobbs CV. Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation. Endocrinology. 151: 5206-17. PMID 20881243 DOI: 10.1210/En.2010-0702  0.408
2010 Yen K, Mobbs CV. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordrecht, Netherlands). 32: 39-49. PMID 19662517 DOI: 10.1007/S11357-009-9110-7  0.542
2009 Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. Plos Biology. 7: e1000245. PMID 19924292 DOI: 10.1371/Journal.Pbio.1000245  0.654
2009 Cheng H, Isoda F, Mobbs CV. Estradiol impairs hypothalamic molecular responses to hypoglycemia. Brain Research. 1280: 77-83. PMID 19445909 DOI: 10.1016/J.Brainres.2009.05.017  0.426
2009 Yen K, Patel HB, Lublin AL, Mobbs CV. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mechanisms of Ageing and Development. 130: 173-8. PMID 19059428 DOI: 10.1016/J.Mad.2008.11.003  0.549
2008 Yen K, Steinsaltz D, Mobbs CV. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Experimental Gerontology. 43: 1044-51. PMID 18832022 DOI: 10.1016/J.Exger.2008.09.006  0.521
2008 Yen K, Mobbs CV. Chemosensory and caloric mechanisms influence distinct components of mortality rate. Experimental Gerontology. 43: 1058-60. PMID 18790043 DOI: 10.1016/J.Exger.2008.08.048  0.566
2008 Cheng H, Isoda F, Belsham DD, Mobbs CV. Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation. Endocrinology. 149: 703-10. PMID 17974626 DOI: 10.1210/En.2007-0772  0.384
2007 Musatov S, Chen W, Pfaff DW, Mobbs CV, Yang XJ, Clegg DJ, Kaplitt MG, Ogawa S. Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104: 2501-6. PMID 17284595 DOI: 10.1073/Pnas.0610787104  0.563
2007 Yang XJ, Mastaitis J, Mizuno T, Mobbs CV. Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression. Endocrinology. 148: 1928-32. PMID 17218412 DOI: 10.1210/En.2006-1312  0.442
2007 Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine. 13: 89-94. PMID 17195839 DOI: 10.1038/Nm1525  0.401
2007 Mobbs CV. The "domino theory" of hunger: the hypothalamus is hot. Cell Metabolism. 5: 1-2. PMID 17189199 DOI: 10.1016/J.Cmet.2006.12.005  0.373
2007 Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite. 48: 135-8. PMID 17141367 DOI: 10.1016/J.Appet.2006.06.007  0.607
2007 Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K. Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdisciplinary Topics in Gerontology. 35: 39-68. PMID 17063032 DOI: 10.1159/000096555  0.637
2005 Zhao Z, Ho L, Wang J, Qin W, Festa ED, Mobbs C, Hof P, Rocher A, Masur S, Haroutunian V, Pasinetti GM. Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2081-2. PMID 16186174 DOI: 10.1096/Fj.05-4359Fje  0.312
2005 Watson E, Hahm S, Mizuno TM, Windsor J, Montgomery C, Scherer PE, Mobbs CV, Salton SR. VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology. 146: 5151-63. PMID 16141392 DOI: 10.1210/En.2005-0588  0.416
2005 Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis. Physiology & Behavior. 85: 3-23. PMID 15924903 DOI: 10.1016/J.Physbeh.2005.04.005  0.754
2005 Mastaitis JW, Wurmbach E, Cheng H, Sealfon SC, Mobbs CV. Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes. 54: 952-8. PMID 15793232 DOI: 10.2337/Diabetes.54.4.952  0.36
2004 Mobbs CV. Not wisely but too well: aging as a cost of neuroendocrine activity. Science of Aging Knowledge Environment : Sage Ke. 2004: pe33. PMID 15342923 DOI: 10.1126/Sageke.2004.35.Pe33  0.312
2004 Yen K, Mastitis JW, Mobbs CV. Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans. Experimental Gerontology. 39: 947-9. PMID 15217699 DOI: 10.1016/J.Exger.2004.03.016  0.545
2004 Mizuno T, Shu IW, Makimura H, Mobbs C. Obesity over the life course. Science of Aging Knowledge Environment : Sage Ke. 2004: re4. PMID 15201431 DOI: 10.1126/Sageke.2004.24.Re4  0.652
2004 Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochemical Research. 29: 1093-103. PMID 15176466 DOI: 10.1023/B:Nere.0000023596.49140.E0  0.599
2004 Mizuno TM, Funabashi T, Kleopoulos SP, Mobbs CV. Specific preservation of biosynthetic responses to insulin in adipose tissue may contribute to hyperleptinemia in insulin-resistant obese mice. The Journal of Nutrition. 134: 1045-50. PMID 15113943 DOI: 10.1093/Jn/134.5.1045  0.375
2004 Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 902-4. PMID 15033922 DOI: 10.1096/Fj.03-0978Fje  0.323
2004 Yang XJ, Kow LM, Pfaff DW, Mobbs CV. Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose. Diabetes. 53: 67-73. PMID 14693699 DOI: 10.2337/Diabetes.53.1.67  0.482
2004 Tanaka SI, Yamakawa T, Kimura M, Aoki I, Kamei J, Okuda K, Mobbs C. Daily nasal inoculation with the insulin gene ameliorates diabetes in mice Diabetes Research and Clinical Practice. 63: 1-9. PMID 14693407 DOI: 10.1016/J.Diabres.2003.07.005  0.344
2003 Isoda F, Shiry L, Abergel J, Allan G, Mobbs C. D-chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose Brain Research. 993: 172-176. PMID 14642843 DOI: 10.1016/J.Brainres.2003.09.008  0.345
2003 Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes. 52: 2675-83. PMID 14578285 DOI: 10.2337/Diabetes.52.11.2675  0.452
2003 Mizuno TM, Makimura H, Mobbs CV. The physiological function of the agouti-related peptide gene: the control of weight and metabolic rate. Annals of Medicine. 35: 425-33. PMID 14572167 DOI: 10.1080/07853890310012076  0.679
2003 Shu IW, Lindenberg DL, Mizuno TM, Roberts JL, Mobbs CV. The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons. Brain Research. 985: 1-12. PMID 12957363 DOI: 10.1016/S0006-8993(03)02806-3  0.389
2003 Li G, Mobbs CV, Scarpace PJ. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes. 52: 1951-7. PMID 12882910 DOI: 10.2337/Diabetes.52.8.1951  0.394
2003 Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV. Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. Bmc Physiology. 3: 5. PMID 12848900 DOI: 10.1186/1472-6793-3-5  0.664
2003 Makimura H, Mizuno TM, Beasley J, Silverstein JH, Mobbs CV. Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity. Bmc Physiology. 3: 4. PMID 12795810 DOI: 10.1186/1472-6793-3-4  0.687
2002 Wurmbach E, González-Maeso J, Yuen T, Ebersole BJ, Mastaitis JW, Mobbs CV, Sealfon SC. Validated genomic approach to study differentially expressed genes in complex tissues. Neurochemical Research. 27: 1027-33. PMID 12462402 DOI: 10.1023/A:1020900720328  0.308
2002 Makimura H, Mizuno TM, Mastaitis JW, Agami R, Mobbs CV. Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. Bmc Neuroscience. 3: 18. PMID 12423556 DOI: 10.1186/1471-2202-3-18  0.681
2002 Makimura H, Mizuno TM, Bergen H, Mobbs CV. Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA. American Journal of Physiology. Endocrinology and Metabolism. 283: E1266-71. PMID 12388167 DOI: 10.1152/Ajpendo.00227.2002  0.685
2002 Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SR. VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6929-38. PMID 12177191 DOI: 10.1523/Jneurosci.22-16-06929.2002  0.425
2002 Mobbs CV, Makimura H. Block the FAS, lose the fat. Nature Medicine. 8: 335-6. PMID 11927935 DOI: 10.1038/Nm0402-335  0.644
2001 Mobbs CV, Bray GA, Atkinson RL, Bartke A, Finch CE, Maratos-Flier E, Crawley JN, Nelson JF. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: 34-44. PMID 12088210 DOI: 10.1093/Gerona/56.Suppl_1.34  0.451
2001 Mobbs CV, Kow LM, Yang XJ. Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. American Journal of Physiology. Endocrinology and Metabolism. 281: E649-54. PMID 11551839 DOI: 10.1152/Ajpendo.2001.281.4.E649  0.358
2001 Makimura H, Mizuno TM, Yang XJ, Silverstein J, Beasley J, Mobbs CV. Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes. 50: 733-9. PMID 11289036 DOI: 10.2337/Diabetes.50.4.733  0.693
2000 Tanaka S, Isoda F, Kiuchi Y, Ikeda H, Mobbs CV, Yamakawa T. T lymphopenia in genetically obese-diabetic Wistar fatty rats: effects of body weight reduction on T cells. Metabolism: Clinical and Experimental. 49: 1261-6. PMID 11079813 DOI: 10.1053/Meta.2000.9516  0.325
2000 Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice. Diabetes. 49: 1917-23. PMID 11078460 DOI: 10.2337/Diabetes.49.11.1917  0.696
2000 Funabashi T, Kleopoulos SP, Brooks PJ, Kimura F, Pfaff DW, Shinohara K, Mobbs CV. Changes in estrogenic regulation of estrogen receptor alpha mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study. Neuroscience Research. 38: 85-92. PMID 10997581 DOI: 10.1016/S0168-0102(00)00150-4  0.486
2000 Mobbs CV, Shiry LJ, Allan G. The effects of d-chiro-inositol administration on hypothalamic gene expression in a model of diet-induced obesity Diabetes Research and Clinical Practice. 50: 394. DOI: 10.1016/S0168-8227(00)81344-3  0.342
1999 Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV. Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1. Endocrinology. 140: 4551-4557. PMID 28200441 DOI: 10.1210/endo.140.10.6966  0.628
1999 Mobbs C, Mizuno T. Leptin regulation of proopiomelanocortin Frontiers of Hormone Research. 26: 57-70. PMID 10767941 DOI: 10.1159/000061015  0.334
1999 Bergen HT, Mizuno T, Taylor J, Mobbs CV. Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain Research. 851: 198-203. PMID 10642844 DOI: 10.1016/S0006-8993(99)02186-1  0.388
1999 Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV. Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology. 140: 4551-7. PMID 10499510 DOI: 10.1210/Endo.140.10.6966  0.69
1999 Medina EA, Stanhope KL, Mizuno TM, Mobbs CV, Gregoire F, Hubbard NE, Erickson KL, Havel PJ. Effects of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 23: 896-903. PMID 10490793 DOI: 10.1038/Sj.Ijo.0800970  0.33
1999 Yang XJ, Kow LM, Funabashi T, Mobbs CV. Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms. Diabetes. 48: 1763-72. PMID 10480606 DOI: 10.2337/Diabetes.48.9.1763  0.331
1999 Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, et al. Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron. 23: 537-48. PMID 10433265 DOI: 10.1016/S0896-6273(00)80806-5  0.407
1999 Mizuno TM, Mobbs CV. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology. 140: 814-7. PMID 9927310 DOI: 10.1210/Endo.140.2.6491  0.37
1998 Funabashi T, Kleopoulos SP, Kimura F, Mobbs CV. Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: an in situ hybridization histochemistry study. General and Comparative Endocrinology. 112: 364-71. PMID 9843642 DOI: 10.1006/Gcen.1998.7139  0.338
1998 Bergen HT, Mizuno TM, Taylor J, Mobbs CV. Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology. 139: 4483-8. PMID 9794456 DOI: 10.1210/Endo.139.11.6324  0.39
1998 Silverstein JH, Beasley J, Mizuno TM, London E, Mobbs CV. Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats. Mechanisms of Ageing and Development. 101: 233-43. PMID 9622227 DOI: 10.1016/S0047-6374(97)00177-2  0.307
1998 Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes. 47: 294-7. PMID 9519731 DOI: 10.2337/Diab.47.2.294  0.388
1998 Mueller WM, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS, Havel PJ. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology. 139: 551-8. PMID 9449624 DOI: 10.1210/Endo.139.2.5716  0.378
1997 Sugiyama A, Hattori S, Tanaka S, Isoda F, Kleopoulos S, Rosenfeld M, Kaplitt M, Sekihara H, Mobbs C. Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice Hormone and Metabolic Research. 29: 599-603. PMID 9497894 DOI: 10.1055/S-2007-979108  0.344
1997 Brooks PJ, Kleopoulos SP, Funabashi T, Mobbs CV, Pfaff DW. Widespread expression and estrogen regulation of PPEIA-3' nuclear RNA in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. 94: 14037-41. PMID 9391148 DOI: 10.1073/Pnas.94.25.14037  0.457
1996 Bergen HT, Mobbs CV. Ventromedial hypothalamic lesions produced by gold thioglucose do not impair induction of NPY mRNA in the arcuate nucleus by fasting. Brain Research. 707: 266-71. PMID 8919304 DOI: 10.1016/0006-8993(95)01270-2  0.416
1996 Bergen HT, Monkman N, Mobbs CV. Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight. Brain Research. 734: 332-6. PMID 8896843 DOI: 10.1016/0006-8993(96)00887-6  0.41
1996 Mizuno TM, Bergen H, Funabashi T, Kleopoulos SP, Zhong YG, Bauman WA, Mobbs CV. Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proceedings of the National Academy of Sciences of the United States of America. 93: 3434-8. PMID 8622953 DOI: 10.1073/Pnas.93.8.3434  0.425
1995 Funabashi T, Brooks PJ, Kleopoulos SP, Grandison L, Mobbs CV, Pfaff DW. Changes in preproenkephalin messenger RNA level in the rat ventromedial hypothalamus during the estrous cycle. Brain Research. Molecular Brain Research. 28: 129-34. PMID 7707866 DOI: 10.1016/0169-328X(94)00191-G  0.482
1994 Kaplitt MG, Kwong AD, Kleopoulos SP, Mobbs CV, Rabkin SD, Pfaff DW. Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector. Proceedings of the National Academy of Sciences of the United States of America. 91: 8979-83. PMID 8090756 DOI: 10.1073/Pnas.91.19.8979  0.452
1994 McCarthy MM, Kleopoulos SP, Mobbs CV, Pfaff DW. Infusion of antisense oligodeoxynucleotides to the oxytocin receptor in the ventromedial hypothalamus reduces estrogen-induced sexual receptivity and oxytocin receptor binding in the female rat. Neuroendocrinology. 59: 432-40. PMID 8022519 DOI: 10.1159/000126689  0.593
1994 Mobbs CV. Molecular hysteresis: residual effects of hormones and glucose on genes during aging. Neurobiology of Aging. 15: 523-34. PMID 7969735 DOI: 10.1016/0197-4580(94)90092-2  0.346
1994 Kow LM, Mobbs CV, Pfaff DW. Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review. Neuroscience and Biobehavioral Reviews. 18: 251-68. PMID 7914686 DOI: 10.1016/0149-7634(94)90028-0  0.477
1994 Funabashi T, Kleopoulos SP, Pfaff DW, Mobbs CV, Kimura F. Estrogen and reproductive aging Neuroscience Research Supplements. 19: S15. DOI: 10.1016/0921-8696(94)92307-8  0.448
1993 Funabashi T, Brooks PJ, Mobbs CV, Pfaff DW. DNA Methylation and DNase-Hypersensitive Sites in the 5' Flanking and Transcribed Regions of the Rat Preproenkephalin Gene: Studies of Mediobasal Hypothalamus. Molecular and Cellular Neurosciences. 4: 499-509. PMID 19912957 DOI: 10.1006/Mcne.1993.1062  0.442
1993 Brooks PJ, Funabashi T, Kleopoulos SP, Mobbs CV, Pfaff DW. Cell-specific expression of preproenkephalin intronic heteronuclear RNA in the rat forebrain. Brain Research. Molecular Brain Research. 19: 22-30. PMID 8361342 DOI: 10.1016/0169-328X(93)90144-E  0.439
1993 Kaplitt MG, Kleopoulos SP, Pfaff DW, Mobbs CV. Estrogen increases HIP-70/PLC-alpha messenger ribonucleic acid in the rat uterus and hypothalamus. Endocrinology. 133: 99-104. PMID 8319593 DOI: 10.1210/Endo.133.1.8319593  0.461
1993 Pfaus JG, Kleopoulos SP, Mobbs CV, Gibbs RB, Pfaff DW. Sexual stimulation activates c-fos within estrogen-concentrating regions of the female rat forebrain. Brain Research. 624: 253-67. PMID 8252398 DOI: 10.1016/0006-8993(93)90085-2  0.623
1993 Brooks PJ, Kaplitt MG, Kleopoulos SP, Funabashi T, Mobbs CV, Pfaff DW. Detection of messenger RNA and low-abundance heteronuclear RNA with single-stranded DNA probes produced by amplified primer extension labeling. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 41: 1761-6. PMID 8245424 DOI: 10.1177/41.12.8245424  0.411
1993 Mobbs CV. Genetic influences on glucose neurotoxicity, aging, and diabetes: a possible role for glucose hysteresis. Genetica. 91: 239-53. PMID 8125273 DOI: 10.1007/Bf01436001  0.37
1993 Funabashi T, Brooks PJ, Kleopoulos SP, Mobbs CV, Kimura F, Pfaff DW. 903 Changes in preproenkephalin (PPE) mRNA levels in the ventromedial hypothalamus (VMH) during the rat estrous cycle Neuroscience Research Supplements. 18: S95. DOI: 10.1016/S0921-8696(05)80938-7  0.455
1992 Olazábal UE, Pfaff DW, Mobbs CV. Estrogenic regulation of heat shock protein 90 kDa in the rat ventromedial hypothalamus and uterus. Molecular and Cellular Endocrinology. 84: 175-83. PMID 1587390 DOI: 10.1016/0303-7207(92)90028-5  0.448
1992 Mobbs CV, Finch CE. Estrogen-induced impairments as a mechanism in reproductive senescence of female C57BL/6J mice. Journal of Gerontology. 47: B48-51. PMID 1538060 DOI: 10.1093/Geronj/47.2.B48  0.486
1992 Olazábal UE, Pfaff DW, Mobbs CV. Sex differences in the regulation of heat shock protein 70 kDa and 90 kDa in the rat ventromedial hypothalamus by estrogen. Brain Research. 596: 311-4. PMID 1467994 DOI: 10.1016/0006-8993(92)91563-T  0.442
1992 Pfaff DW, Brooks PJ, Funabashi T, Pfaus JG, Mobbs CV. Gene memory in neuroendocrine and behavioural systems. Ciba Foundation Symposium. 168: 165-83; discussion 1. PMID 1425024  0.603
1992 Brooks PJ, Funabashi T, Kleopoulos SP, Mobbs CV, Pfaff DW. Prolactin receptor messenger RNA is synthesized by the epithelial cells of the choroid plexus. Brain Research. Molecular Brain Research. 16: 163-7. PMID 1281254 DOI: 10.1016/0169-328X(92)90207-R  0.441
1991 Mobbs CV, Kaplitt M, Kow LM, Pfaff DW. PLC-alpha: a common mediator of the action of estrogen and other hormones? Molecular and Cellular Endocrinology. 80: C187-91. PMID 1955069 DOI: 10.1016/0303-7207(91)90136-G  0.478
1991 Lauber AH, Mobbs CV, Muramatsu M, Pfaff DW. Estrogen receptor messenger RNA expression in rat hypothalamus as a function of genetic sex and estrogen dose. Endocrinology. 129: 3180-6. PMID 1954897 DOI: 10.1210/Endo-129-6-3180  0.497
1990 Gibbs RB, Mobbs CV, Pfaff DW. Sex steroids and fos expression in rat brain and uterus. Molecular and Cellular Neurosciences. 1: 29-40. PMID 19912752 DOI: 10.1016/1044-7431(90)90039-7  0.474
1990 Lauber AH, Romano GJ, Mobbs CV, Pfaff DW. Estradiol Regulation of Estrogen Receptor Messenger Ribonucleic Acid in Rat Mediobasal Hypothalamus: An in situ Hybridization Study. Journal of Neuroendocrinology. 2: 605-11. PMID 19215395 DOI: 10.1111/J.1365-2826.1990.Tb00454.X  0.487
1990 Mobbs CV, Fink G, Pfaff DW. HIP-70: an isoform of phosphoinositol-specific phospholipase C-alpha. Science (New York, N.Y.). 249: 566-7. PMID 2382136 DOI: 10.1126/Science.2382136  0.393
1990 Mobbs CV, Fink G, Pfaff DW. HIP-70: a protein induced by estrogen in the brain and LH-RH in the pituitary. Science (New York, N.Y.). 247: 1477-9. PMID 2181662 DOI: 10.1126/Science.2181662  0.47
1990 Lauber AH, Romano GJ, Mobbs CV, Howells RD, Pfaff DW. Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rat. Brain Research. Molecular Brain Research. 8: 47-54. PMID 2166200 DOI: 10.1016/0169-328X(90)90008-2  0.468
1990 Romano GJ, Mobbs CV, Lauber A, Howells RD, Pfaff DW. Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats: implications for the molecular basis of a sexually differentiated behavior. Brain Research. 536: 63-8. PMID 1707724 DOI: 10.1016/0006-8993(90)90009-Z  0.505
1989 Romano GJ, Mobbs CV, Howells RD, Pfaff DW. Estrogen regulation of proenkephalin gene expression in the ventromedial hypothalamus of the rat: temporal qualities and synergism with progesterone. Brain Research. Molecular Brain Research. 5: 51-8. PMID 2927283 DOI: 10.1016/0169-328X(89)90017-X  0.508
1989 Lustig RH, Pfaff DW, Mobbs CV. Two-dimensional gel autoradiographic analysis of the acute effects of estradiol on protein synthesis in the female rat ventromedial nucleus in vivo. Endocrinology. 124: 1863-9. PMID 2924728 DOI: 10.1210/Endo-124-4-1863  0.436
1989 Lustig RH, Mobbs CV, Bradlow HL, McEwen BS, Pfaff DW. Differential effects of estradiol and 16 alpha-hydroxyestrone on pituitary and preoptic estrogen receptor regulation. Endocrinology. 125: 2701-9. PMID 2792004 DOI: 10.1210/Endo-125-5-2701  0.469
1989 Lustig RH, Mobbs CV, Pfaff DW, Fishman J. Temporal actions of 16 alpha-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites and between sexes. Journal of Steroid Biochemistry. 33: 417-21. PMID 2779234 DOI: 10.1016/0022-4731(89)90332-4  0.467
1989 Lustig RH, Pfaff DW, Mobbs CV. Considerations in the quantitative analysis of autoradiograms from 2-dimensional gels. Journal of Neuroscience Methods. 29: 17-26. PMID 2761295 DOI: 10.1016/0165-0270(89)90104-0  0.389
1989 Mobbs C, Berman J, Marquardt M, Pfaff D. Comprehensive polypeptide analysis of microdissected rat brain areas: combining 2-dimensional gel electrophoresis with 2-dimensional HPLC and immunoanalysis and sequencing procedures. Journal of Neuroscience Methods. 29: 5-15. PMID 2668649 DOI: 10.1016/0165-0270(89)90103-9  0.414
1989 Mobbs C, Fink G, Johnson M, Welch W, Pfaff D. Similarity of an estrogen-induced protein and a luteinizing hormone releasing hormone-induced protein Molecular and Cellular Endocrinology. 62: 297-306. PMID 2663572 DOI: 10.1016/0303-7207(89)90017-8  0.302
1989 Mobbs CV, Rothfeld JM, Saluja R, Pfaff DW. Phorbol esters and forskolin infused into midbrain central gray facilitate lordosis. Pharmacology, Biochemistry, and Behavior. 34: 665-7. PMID 2623023 DOI: 10.1016/0091-3057(89)90572-8  0.452
1988 Gordon MN, Mobbs CV, Finch CE. Pituitary and hypothalamic glucose-6-phosphate dehydrogenase: effects of estradiol and age in C57BL/6J mice. Endocrinology. 122: 726-33. PMID 3338416 DOI: 10.1210/Endo-122-2-726  0.529
1988 Telford N, Mobbs CV, Osterburg HH, Finch CE. Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice. Experimental Gerontology. 23: 481-9. PMID 3250884 DOI: 10.1016/0531-5565(88)90060-5  0.482
1988 Mobbs CV, Harlan RE, Burrous MR, Pfaff DW. An estradiol-induced protein synthesized in the ventral medial hypothalamus and transported to the midbrain central gray. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 113-8. PMID 2828560 DOI: 10.1523/Jneurosci.08-01-00113.1988  0.459
1987 Mobbs CV, Pfaff DW. Estradiol-Regulated Neuronal Plasticity Current Topics in Membranes and Transport. 31: 191-215. DOI: 10.1016/S0070-2161(08)60061-1  0.445
1986 Telford N, Mobbs CV, Sinha YN, Finch CE. The increase of anterior pituitary dopamine in aging C57BL/6J female mice is caused by ovarian steroids, not intrinsic pituitary aging. Neuroendocrinology. 43: 135-42. PMID 3724983 DOI: 10.1159/000124520  0.504
1985 Mobbs CV, Kannegieter LS, Finch CE. Delayed anovulatory syndrome induced by estradiol in female C57BL/6J mice: age-like neuroendocrine, but not ovarian, impairments. Biology of Reproduction. 32: 1010-7. PMID 4040400 DOI: 10.1095/Biolreprod32.5.1010  0.491
1985 Gordon MN, Mobbs CV, Finch CE. The antiestrogen LY117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum LH. Neuroendocrinology. 40: 381-4. PMID 4010886 DOI: 10.1159/000124102  0.514
1985 Mobbs CV, Cheyney D, Sinha YN, Finch CE. Age-correlated and ovary-dependent changes in relationships between plasma estradiol and luteinizing hormone, prolactin, and growth hormone in female C57BL/6J mice. Endocrinology. 116: 813-20. PMID 3967630 DOI: 10.1210/Endo-116-2-813  0.497
1984 Gee DM, Flurkey K, Mobbs CV, Sinha YN, Finch CE. The regulation of luteinizing hormone and prolactin in C57BL/6J mice: effects of estradiol implant size, duration of ovariectomy, and aging. Endocrinology. 114: 685-93. PMID 6697956 DOI: 10.1210/Endo-114-3-685  0.468
1984 Mobbs CV, Gee DM, Finch CE. Reproductive senescence in female C57BL/6J mice: ovarian impairments and neuroendocrine impairments that are partially reversible and delayable by ovariectomy. Endocrinology. 115: 1653-62. PMID 6541567 DOI: 10.1210/Endo-115-5-1653  0.49
1984 Mobbs CV, Flurkey K, Gee DM, Yamamoto K, Sinha YN, Finch CE. Estradiol-induced adult anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian, impairments. Biology of Reproduction. 30: 556-63. PMID 6539132 DOI: 10.1095/Biolreprod30.3.556  0.494
1984 Morgan DG, Mobbs CV, Anderson CP, Sinha YN, Finch CE. Hyperprolactinemia fails to increase striatal dopamine receptors in male and female C57BL/6J mice. European Journal of Pharmacology. 107: 101-4. PMID 6526068 DOI: 10.1016/0014-2999(84)90097-9  0.469
1984 Finch CE, Felicio LS, Mobbs CV, Nelson JF. Ovarian and steroidal influences on neuroendocrine aging processes in female rodents. Endocrine Reviews. 5: 467-97. PMID 6389107 DOI: 10.1210/Edrv-5-4-467  0.494
1980 Finch C, Felicio L, Flurkey K, Gee D, Mobbs C, Nelson J, Osterburg H. Studies on ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice Peptides. 1: 163-175. DOI: 10.1016/0196-9781(80)90114-X  0.528
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