Lori Isom - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Sodium Channels

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhu W, Wang W, Angsutararux P, Mellor RL, Isom LL, Nerbonne JM, Silva JR. Modulation of the effects of Class-Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits. Jci Insight. PMID 34156986 DOI: 10.1172/jci.insight.143092  0.35
2021 Bouza AA, Edokobi N, Hodges SL, Pinsky AM, Offord J, Piao L, Zhao YT, Lopatin AN, Lopez-Santiago LF, Isom LL. Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling. Jci Insight. PMID 33411695 DOI: 10.1172/jci.insight.141776  0.421
2020 Hull JM, O'Malley HA, Chen C, Yuan Y, Denomme N, Bouza AA, Anumonwo C, Lopez-Santiago LF, Isom LL. Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Annals of Clinical and Translational Neurology. PMID 32979291 DOI: 10.1002/acn3.51205  0.813
2020 Han Z, Chen C, Christiansen A, Ji S, Lin Q, Anumonwo C, Liu C, Leiser SC, Meena, Aznarez I, Liau G, Isom LL. Antisense oligonucleotides increase expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Science Translational Medicine. 12. PMID 32848094 DOI: 10.1126/scitranslmed.aaz6100  0.317
2020 Bouza AA, Philippe JM, Edokobi N, Pinsky AM, Offord J, Calhoun JD, Lopez-Florán M, Lopez-Santiago LF, Jenkins PM, Isom LL. Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. The Journal of Biological Chemistry. PMID 32503841 DOI: 10.1074/Jbc.Ra120.013978  0.727
2020 Denomme N, Lukowski AL, Hull JM, Jameson MB, Narayan ARH, Isom LL. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Na1.1 in addition to Na1.6. Neuroscience Letters. 134853. PMID 32114117 DOI: 10.1016/j.neulet.2020.134853  0.313
2019 Aeby A, Sculier C, Bouza AA, Askar B, Lederer D, Schoonjans AS, Vander Ghinst M, Ceulemans B, Offord J, Lopez-Santiago LF, Isom LL. SCN1B-linked early infantile developmental and epileptic encephalopathy. Annals of Clinical and Translational Neurology. PMID 31709768 DOI: 10.1002/acn3.50921  0.386
2019 O'Malley HA, Hull JM, Clawson BC, Chen C, Owens-Fiestan G, Jameson MB, Aton SJ, Parent JM, Isom LL. deletion in adult mice results in seizures and SUDEP. Annals of Clinical and Translational Neurology. 6: 1121-1126. PMID 31211177 DOI: 10.1002/Acn3.785  0.745
2019 Isom LL. Is Targeting of Compensatory Ion Channel Gene Expression a Viable Therapeutic Strategy for Dravet Syndrome? Epilepsy Currents. 1535759719844780. PMID 31035820 DOI: 10.1177/1535759719844780  0.345
2019 Yuan Y, O'Malley HA, Smaldino MA, Bouza AA, Hull JM, Isom LL. Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome. Scientific Reports. 9: 6210. PMID 30996233 DOI: 10.1038/s41598-019-42191-0  0.748
2019 Lopez-Santiago L, Isom LL. Dravet Syndrome: A Developmental and Epileptic Encephalopathy. Epilepsy Currents. 19: 51-53. PMID 30838929 DOI: 10.1177/1535759718822038  0.381
2018 Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth J, Gorelik J, Poelzing S, Gourdie RG. The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation. Elife. 7. PMID 30106376 DOI: 10.7554/Elife.37610  0.356
2018 Edokobi N, Isom LL. Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology. Frontiers in Physiology. 9: 351. PMID 29740331 DOI: 10.3389/fphys.2018.00351  0.414
2017 Bouza AA, Isom LL. Voltage-Gated Sodium Channel β Subunits and Their Related Diseases. Handbook of Experimental Pharmacology. PMID 28965169 DOI: 10.1007/164_2017_48  0.433
2017 Hull JM, Isom LL. Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease. Neuropharmacology. PMID 28927993 DOI: 10.1016/j.neuropharm.2017.09.018  0.382
2017 Lopez-Santiago LF, Yuan Y, Wagnon JL, Hull JM, Frasier CR, O'Malley HA, Meisler MH, Isom LL. Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193882 DOI: 10.1073/Pnas.1616821114  0.771
2016 Bao Y, Willis BC, Frasier CR, Lopez-Santiago LF, Lin X, Ramos-Mondragón R, Auerbach DS, Chen C, Wang Z, Anumonwo J, Valdivia HH, Delmar M, Jalife J, Isom LL. Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias. Circulation. Arrhythmia and Electrophysiology. 9. PMID 27932425 DOI: 10.1161/CIRCEP.116.003923  0.333
2016 Frasier CR, Wagnon JL, Bao YO, McVeigh LG, Lopez-Santiago LF, Meisler MH, Isom LL. Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791149 DOI: 10.1073/Pnas.1612746113  0.365
2016 Winters JJ, Isom LL. Developmental and Regulatory Functions of Na(+) Channel Non-pore-forming β Subunits. Current Topics in Membranes. 78: 315-51. PMID 27586289 DOI: 10.1016/bs.ctm.2016.07.003  0.401
2016 Kruger LC, O'Malley HA, Hull JM, Kleeman A, Patino GA, Isom LL. β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 6213-24. PMID 27277800 DOI: 10.1523/Jneurosci.0405-16.2016  0.763
2016 Kruger LC, Isom LL. Voltage-Gated Na+ Channels: Not Just for Conduction. Cold Spring Harbor Perspectives in Biology. 8. PMID 27252364 DOI: 10.1101/Cshperspect.A029264  0.806
2016 Kaplan DI, Isom LL, Petrou S. Role of Sodium Channels in Epilepsy. Cold Spring Harbor Perspectives in Medicine. PMID 27143702 DOI: 10.1101/cshperspect.a022814  0.322
2015 Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, ... ... Isom LL, et al. Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nature Communications. 6: 8803. PMID 26541940 DOI: 10.1038/Ncomms9803  0.732
2015 Lin X, O'Malley H, Chen C, Auerbach D, Foster M, Shekhar A, Zhang M, Coetzee W, Jalife J, Fishman GI, Isom L, Delmar M. Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. The Journal of Physiology. 593: 1389-407. PMID 25772295 DOI: 10.1113/Jphysiol.2014.277699  0.808
2015 O'Malley HA, Isom LL. Sodium channel β subunits: emerging targets in channelopathies. Annual Review of Physiology. 77: 481-504. PMID 25668026 DOI: 10.1146/Annurev-Physiol-021014-071846  0.803
2014 Lee A, Fakler B, Kaczmarek LK, Isom LL. More than a pore: ion channel signaling complexes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15159-69. PMID 25392484 DOI: 10.1523/JNEUROSCI.3275-14.2014  0.501
2014 Yuan Y, Isom LL. SUMOylation of Neuronal K⁺ channels: a potential therapeutic pathway for epilepsy and SUDEP? Neuron. 83: 996-8. PMID 25189206 DOI: 10.1016/j.neuron.2014.08.026  0.315
2014 Lin X, O'Malley H, Chen C, Auerbach D, Foster M, Shekhar A, Zhang M, Coetzee W, Jalife J, Fishman GI, Isom L, Delmar M. Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. The Journal of Physiology. PMID 25128572 DOI: 10.1113/jphysiol.2014.277699  0.398
2014 Chopra R, Isom LL. Untangling the dravet syndrome seizure network: the changing face of a rare genetic epilepsy. Epilepsy Currents / American Epilepsy Society. 14: 86-9. PMID 24872787 DOI: 10.5698/1535-7597-14.2.86  0.358
2014 Calhoun JD, Isom LL. The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels. Handbook of Experimental Pharmacology. 221: 51-89. PMID 24737232 DOI: 10.1007/978-3-642-41588-3_4  0.796
2014 Isom L. Sodium Channel β1 Subunits: Overachievers of the Ion Channel Family Biophysical Journal. 106: 9a. DOI: 10.1016/j.bpj.2013.11.096  0.531
2013 Liu Y, Lopez-Santiago LF, Yuan Y, Jones JM, Zhang H, O'Malley HA, Patino GA, O'Brien JE, Rusconi R, Gupta A, Thompson RC, Natowicz MR, Meisler MH, Isom LL, Parent JM. Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Annals of Neurology. 74: 128-39. PMID 23821540 DOI: 10.1002/Ana.23897  0.813
2013 Brackenbury WJ, Yuan Y, O'Malley HA, Parent JM, Isom LL. Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proceedings of the National Academy of Sciences of the United States of America. 110: 1089-94. PMID 23277545 DOI: 10.1073/Pnas.1208767110  0.789
2013 Isom L, Patino G, Lopez-Santiago L, Yuan Y. Voltage-gated ion channels Neuroscience in the 21st Century: From Basic to Clinical. 29-58. DOI: 10.1007/978-1-4614-1997-6_3  0.752
2012 Uebachs M, Albus C, Opitz T, Isom L, Niespodziany I, Wolff C, Beck H. Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia. 53: 1959-67. PMID 23016711 DOI: 10.1111/j.1528-1167.2012.03675.x  0.485
2012 Chen C, Calhoun JD, Zhang Y, Lopez-Santiago L, Zhou N, Davis TH, Salzer JL, Isom LL. Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits. The Journal of Biological Chemistry. 287: 39061-9. PMID 22992729 DOI: 10.1074/Jbc.M112.397646  0.834
2012 Yang M, Kozminski DJ, Wold LA, Modak R, Calhoun JD, Isom LL, Brackenbury WJ. Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer. Breast Cancer Research and Treatment. 134: 603-15. PMID 22678159 DOI: 10.1007/S10549-012-2102-9  0.742
2012 Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM. The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5716-27. PMID 22539834 DOI: 10.1523/Jneurosci.6450-11.2012  0.457
2012 Nguyen HM, Calhoun JD, Isom LL, Goldin AL, Chandy GK. Modulation of Kv1 Voltage-Gated Potassium Channels by Sodium Channel Beta Subunits Biophysical Journal. 102: 687a. DOI: 10.1016/J.Bpj.2011.11.3733  0.792
2011 Brackenbury WJ, Isom LL. Na Channel β Subunits: Overachievers of the Ion Channel Family. Frontiers in Pharmacology. 2: 53. PMID 22007171 DOI: 10.3389/Fphar.2011.00053  0.466
2011 Patino GA, Brackenbury WJ, Bao Y, Lopez-Santiago LF, O'Malley HA, Chen C, Calhoun JD, Lafrenière RG, Cossette P, Rouleau GA, Isom LL. Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14577-91. PMID 21994374 DOI: 10.1523/Jneurosci.0361-11.2011  0.794
2011 Lin X, Liu N, Lu J, Zhang J, Anumonwo JM, Isom LL, Fishman GI, Delmar M. Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 1923-30. PMID 21767519 DOI: 10.1016/J.Hrthm.2011.07.016  0.369
2011 Sato PY, Coombs W, Lin X, Nekrasova O, Green KJ, Isom LL, Taffet SM, Delmar M. Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circulation Research. 109: 193-201. PMID 21617128 DOI: 10.1161/Circresaha.111.247023  0.303
2011 Lopez-Santiago LF, Brackenbury WJ, Chen C, Isom LL. Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo. The Journal of Biological Chemistry. 286: 22913-23. PMID 21555511 DOI: 10.1074/Jbc.M111.242370  0.385
2010 O'Malley HA, Park Y, Isom LL, Gnegy ME. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience Letters. PMID 20685611 DOI: 10.1016/j.neulet.2010.05.091  0.723
2010 O'Malley HA, Park Y, Isom LL, Gnegy ME. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience Letters. 480: 40-3. PMID 20641161  0.745
2010 Patino GA, Isom LL. Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease. Neuroscience Letters. 486: 53-9. PMID 20600605 DOI: 10.1016/J.Neulet.2010.06.050  0.798
2010 Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H. Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8489-501. PMID 20573896 DOI: 10.1523/JNEUROSCI.1534-10.2010  0.501
2010 Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 107: 2283-8. PMID 20133873 DOI: 10.1073/Pnas.0909434107  0.782
2010 Bai Y, Zhang X, Katona I, Saporta MA, Shy ME, O'Malley HA, Isom LL, Suter U, Li J. Conduction block in PMP22 deficiency. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 600-8. PMID 20071523 DOI: 10.1523/Jneurosci.4264-09.2010  0.746
2009 Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Miyazaki H, Nukina N, Oyama F, De Jonghe P, Isom LL. A functional null mutation of SCN1B in a patient with Dravet syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10764-78. PMID 19710327 DOI: 10.1523/Jneurosci.2475-09.2009  0.831
2009 Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patiño GA, Taffet SM, Isom LL, Delmar M. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circulation Research. 105: 523-6. PMID 19661460 DOI: 10.1161/Circresaha.109.201418  0.767
2009 McEwen DP, Chen C, Meadows LS, Lopez-Santiago L, Isom LL. The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin. Neuroscience Letters. 462: 272-5. PMID 19596049 DOI: 10.1016/J.Neulet.2009.07.020  0.766
2009 Aman TK, Grieco-Calub TM, Chen C, Rusconi R, Slat EA, Isom LL, Raman IM. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2027-42. PMID 19228957 DOI: 10.1523/Jneurosci.4531-08.2009  0.438
2009 Chioni AM, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MB. A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. The International Journal of Biochemistry & Cell Biology. 41: 1216-27. PMID 19041953 DOI: 10.1016/J.Biocel.2008.11.001  0.761
2009 O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Molecular and Cellular Neurosciences. 40: 143-55. PMID 19013247 DOI: 10.1016/J.Mcn.2008.10.001  0.804
2008 Fein AJ, Wright MA, Slat EA, Ribera AB, Isom LL. scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12510-22. PMID 19020043 DOI: 10.1523/Jneurosci.4329-08.2008  0.844
2008 Brackenbury WJ, Djamgoz MB, Isom LL. An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 14: 571-83. PMID 18940784 DOI: 10.1177/1073858408320293  0.415
2008 Brackenbury WJ, Isom LL. Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opinion On Therapeutic Targets. 12: 1191-203. PMID 18694383 DOI: 10.1517/14728222.12.9.1191  0.397
2008 Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL. Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3246-56. PMID 18354028 DOI: 10.1523/Jneurosci.5446-07.2008  0.716
2007 Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. Journal of Molecular and Cellular Cardiology. 43: 636-47. PMID 17884088 DOI: 10.1016/J.Yjmcc.2007.07.062  0.806
2007 Chen C, Dickendesher TL, Oyama F, Miyazaki H, Nukina N, Isom LL. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b. Genesis (New York, N.Y. : 2000). 45: 547-53. PMID 17868089 DOI: 10.1002/Dvg.20324  0.454
2007 Fein AJ, Meadows LS, Chen C, Slat EA, Isom LL. Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant. Bmc Genomics. 8: 226. PMID 17623064 DOI: 10.1186/1471-2164-8-226  0.841
2006 Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I, Isom LL. Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7984-94. PMID 16870743 DOI: 10.1523/JNEUROSCI.2211-06.2006  0.45
2006 Maier SK, Westenbroek RE, Chen C, Isom LL, Maass AH, Catterall WA, Scheuer T. AB16-5 Heart Rhythm. 3: S33-S34. DOI: 10.1016/j.hrthm.2006.02.116  0.311
2005 Pertin M, Ji RR, Berta T, Powell AJ, Karchewski L, Tate SN, Isom LL, Woolf CJ, Gilliard N, Spahn DR, Decosterd I. Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10970-80. PMID 16306410 DOI: 10.1523/JNEUROSCI.3066-05.2005  0.396
2005 Meadows LS, Isom LL. Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovascular Research. 67: 448-58. PMID 15919069 DOI: 10.1016/j.cardiores.2005.04.003  0.32
2005 Grieco TM, Malhotra JD, Chen C, Isom LL, Raman IM. Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 45: 233-44. PMID 15664175 DOI: 10.1016/J.Neuron.2004.12.035  0.475
2004 Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL, Meisler MH. A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10022-34. PMID 15525788 DOI: 10.1523/Jneurosci.2034-04.2004  0.806
2004 McEwen DP, Isom LL. Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules. The Journal of Biological Chemistry. 279: 52744-52. PMID 15466474 DOI: 10.1074/Jbc.M405990200  0.772
2004 Davis TH, Chen C, Isom LL. Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons. The Journal of Biological Chemistry. 279: 51424-32. PMID 15452131 DOI: 10.1074/jbc.M410830200  0.699
2004 Malhotra JD, Thyagarajan V, Chen C, Isom LL. Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. The Journal of Biological Chemistry. 279: 40748-54. PMID 15272007 DOI: 10.1074/jbc.M407243200  0.408
2004 Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, ... ... Isom LL, et al. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4030-42. PMID 15102918 DOI: 10.1523/Jneurosci.4139-03.2004  0.843
2004 McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL. Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. The Journal of Biological Chemistry. 279: 16044-9. PMID 14761957 DOI: 10.1074/Jbc.M400856200  0.778
2003 Aronica E, Troost D, Rozemuller AJ, Yankaya B, Jansen GH, Isom LL, Gorter JA. Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies. Acta Neuropathologica. 105: 515-23. PMID 12677453 DOI: 10.1007/S00401-003-0677-2  0.407
2002 Meadows LS, Malhotra J, Loukas A, Thyagarajan V, Kazen-Gillespie KA, Koopman MC, Kriegler S, Isom LL, Ragsdale DS. Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10699-709. PMID 12486163 DOI: 10.1523/Jneurosci.22-24-10699.2002  0.79
2002 Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, ... ... Isom LL, et al. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proceedings of the National Academy of Sciences of the United States of America. 99: 17072-7. PMID 12481039 DOI: 10.1073/Pnas.212638099  0.66
2002 Gorter JA, van Vliet EA, Lopes da Silva FH, Isom LL, Aronica E. Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy. The European Journal of Neuroscience. 16: 360-4. PMID 12169118 DOI: 10.1046/j.1460-9568.2002.02078.x  0.438
2002 Malhotra JD, Koopmann MC, Kazen-Gillespie KA, Fettman N, Hortsch M, Isom LL. Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin. The Journal of Biological Chemistry. 277: 26681-8. PMID 11997395 DOI: 10.1074/jbc.M202354200  0.354
2002 Isom LL. The role of sodium channels in cell adhesion. Frontiers in Bioscience : a Journal and Virtual Library. 7: 12-23. PMID 11779698  0.483
2002 Isom LL. Beta subunits: players in neuronal hyperexcitability? Novartis Foundation Symposium. 241: 124-38; discussion 1. PMID 11771642  0.529
2001 Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC. Contactin associates with Na+ channels and increases their functional expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7517-25. PMID 11567041 DOI: 10.1523/Jneurosci.21-19-07517.2001  0.803
2001 Isom LL. Sodium channel beta subunits: anything but auxiliary. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 7: 42-54. PMID 11486343 DOI: 10.1177/107385840100700108  0.505
2001 Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA. Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron. 30: 105-19. PMID 11343648 DOI: 10.1016/S0896-6273(01)00266-5  0.697
2001 Meadows L, Malhotra JD, Stetzer A, Isom LL, Ragsdale DS. The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit. Journal of Neurochemistry. 76: 1871-8. PMID 11259505 DOI: 10.1046/J.1471-4159.2001.00192.X  0.779
2001 Dhar Malhotra J, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS, Isom LL. Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation. 103: 1303-10. PMID 11238277 DOI: 10.1161/01.Cir.103.9.1303  0.411
2000 Malhotra JD, Kazen-Gillespie K, Hortsch M, Isom LL. Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. The Journal of Biological Chemistry. 275: 11383-8. PMID 10753953 DOI: 10.1074/jbc.275.15.11383  0.407
2000 Isom LL. I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain? I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain? American Journal of Physiology. Gastrointestinal and Liver Physiology. 278: G349-53. PMID 10712253 DOI: 10.1152/AJPGI.2000.278.3.G349  0.424
2000 Kazen-Gillespie KA, Ragsdale DS, D'Andrea MR, Mattei LN, Rogers KE, Isom LL. Cloning, localization, and functional expression of sodium channel beta1A subunits. The Journal of Biological Chemistry. 275: 1079-88. PMID 10625649 DOI: 10.1074/Jbc.275.2.1079  0.766
1999 Xiao ZC, Ragsdale DS, Malhotra JD, Mattei LN, Braun PE, Schachner M, Isom LL. Tenascin-R is a functional modulator of sodium channel beta subunits. The Journal of Biological Chemistry. 274: 26511-7. PMID 10473612 DOI: 10.1074/Jbc.274.37.26511  0.77
1998 McCormick KA, Isom LL, Ragsdale D, Smith D, Scheuer T, Catterall WA. Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit. The Journal of Biological Chemistry. 273: 3954-62. PMID 9461582 DOI: 10.1074/Jbc.273.7.3954  0.787
1996 Isom LL, Catterall WA. Na+ channel subunits and Ig domains. Nature. 383: 307-8. PMID 8848042 DOI: 10.1038/383307b0  0.548
1996 Jones JM, Meisler MH, Isom LL. Scn2b, a voltage-gated sodium channel beta2 gene on mouse chromosome 9. Genomics. 34: 258-9. PMID 8661062 DOI: 10.1006/Geno.1996.0279  0.378
1995 Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BF, Scheuer T, Catterall WA. Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 83: 433-42. PMID 8521473 DOI: 10.1016/0092-8674(95)90121-3  0.813
1995 Isom LL, Scheuer T, Brownstein AB, Ragsdale DS, Murphy BJ, Catterall WA. Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. The Journal of Biological Chemistry. 270: 3306-12. PMID 7852416 DOI: 10.1074/Jbc.270.7.3306  0.808
1995 Qu Y, Isom LL, Westenbroek RE, Rogers JC, Tanada TN, McCormick KA, Scheuer T, Catterall WA. Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits. The Journal of Biological Chemistry. 270: 25696-701. PMID 7592748 DOI: 10.1074/jbc.270.43.25696  0.606
1994 Patton DE, Isom LL, Catterall WA, Goldin AL. The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. The Journal of Biological Chemistry. 269: 17649-55. PMID 8021275  0.555
1994 Isom LL, De Jongh KS, Catterall WA. Auxiliary subunits of voltage-gated ion channels. Neuron. 12: 1183-94. PMID 7516685 DOI: 10.1016/0896-6273(94)90436-7  0.538
1992 Isom LL, De Jongh KS, Patton DE, Reber BF, Offord J, Charbonneau H, Walsh K, Goldin AL, Catterall WA. Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science (New York, N.Y.). 256: 839-42. PMID 1375395 DOI: 10.1126/Science.1375395  0.605
Show low-probability matches.