Lori Isom - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Sodium Channels

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Year Citation  Score
2019 Beck VC, Hull JM, Isom LL. Beyond Dravet Syndrome: Characterization of a Novel, More Severe SCN1A-Linked Epileptic Encephalopathy. Epilepsy Currents. 1535759719858339. PMID 31257984 DOI: 10.1177/1535759719858339  0.52
2019 O'Malley HA, Hull JM, Clawson BC, Chen C, Owens-Fiestan G, Jameson MB, Aton SJ, Parent JM, Isom LL. deletion in adult mice results in seizures and SUDEP. Annals of Clinical and Translational Neurology. 6: 1121-1126. PMID 31211177 DOI: 10.1002/acn3.785  0.72
2019 Yuan Y, O'Malley HA, Smaldino MA, Bouza AA, Hull JM, Isom LL. Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome. Scientific Reports. 9: 6210. PMID 30996233 DOI: 10.1038/s41598-019-42191-0  0.52
2019 Lopez-Santiago L, Isom LL. Dravet Syndrome: A Developmental and Epileptic Encephalopathy. Epilepsy Currents. 19: 51-53. PMID 30838929 DOI: 10.1177/1535759718822038  0.4
2018 Frasier CR, Zhang H, Offord J, Dang LT, Auerbach DS, Shi H, Chen C, Goldman AM, Eckhardt LL, Bezzerides VJ, Parent JM, Isom LL. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. PMID 30146492 DOI: 10.1016/j.stemcr.2018.07.012  0.72
2018 Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LL. deletion fails to rescue premature lethality in two models of sodium channel epilepsy. Annals of Clinical and Translational Neurology. 5: 982-987. PMID 30128323 DOI: 10.1002/acn3.599  0.72
2018 Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth J, Gorelik J, Poelzing S, Gourdie RG. The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation. Elife. 7. PMID 30106376 DOI: 10.7554/eLife.37610  0.72
2017 Bouza AA, Isom LL. Voltage-Gated Sodium Channel β Subunits and Their Related Diseases. Handbook of Experimental Pharmacology. PMID 28965169 DOI: 10.1007/164_2017_48  0.32
2017 Hull JM, Isom LL. Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease. Neuropharmacology. PMID 28927993 DOI: 10.1016/j.neuropharm.2017.09.018  0.52
2017 Lopez-Santiago LF, Yuan Y, Wagnon JL, Hull JM, Frasier CR, O'Malley HA, Meisler MH, Isom LL. Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193882 DOI: 10.1073/pnas.1616821114  0.52
2016 Bao Y, Willis BC, Frasier CR, Lopez-Santiago LF, Lin X, Ramos-Mondragón R, Auerbach DS, Chen C, Wang Z, Anumonwo J, Valdivia HH, Delmar M, Jalife J, Isom LL. Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias. Circulation. Arrhythmia and Electrophysiology. 9. PMID 27932425 DOI: 10.1161/CIRCEP.116.003923  0.72
2016 Hull JM, Isom LL. Expecting the Unexpected: Lack of In Vivo Network Defects in an Scn1a Model of Dravet Syndrome. Epilepsy Currents. 16: 408-410. PMID 27857626 DOI: 10.5698/1535-7511-16.6.408  0.52
2016 Kruger LC, O'Malley HA, Hull JM, Kleeman A, Patino GA, Isom LL. β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 6213-24. PMID 27277800 DOI: 10.1523/JNEUROSCI.0405-16.2016  0.72
2016 Kruger LC, Isom LL. Voltage-Gated Na+ Channels: Not Just for Conduction. Cold Spring Harbor Perspectives in Biology. 8. PMID 27252364 DOI: 10.1101/cshperspect.a029264  0.52
2016 Offord J, Isom LL. Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit. Critical Reviews in Biochemistry and Molecular Biology. 1-11. PMID 27112431 DOI: 10.3109/10409238.2016.1173010  0.36
2015 Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, ... ... Isom LL, et al. Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nature Communications. 6: 8803. PMID 26541940 DOI: 10.1038/ncomms9803  0.72
2015 Lin X, O'Malley H, Chen C, Auerbach D, Foster M, Shekhar A, Zhang M, Coetzee W, Jalife J, Fishman GI, Isom L, Delmar M. Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. The Journal of Physiology. 593: 1389-407. PMID 25772295 DOI: 10.1113/jphysiol.2014.277699  0.72
2015 O'Malley HA, Isom LL. Sodium channel β subunits: emerging targets in channelopathies. Annual Review of Physiology. 77: 481-504. PMID 25668026 DOI: 10.1146/annurev-physiol-021014-071846  0.72
2014 Isom LL. "It was the interneuron with the parvalbumin in the hippocampus!" "no, it was the pyramidal cell with the glutamate in the cortex!" searching for clues to the mechanism of dravet syndrome - the plot thickens. Epilepsy Currents / American Epilepsy Society. 14: 350-2. PMID 25678872 DOI: 10.5698/1535-7597-14.6.350  0.72
2014 Lee A, Fakler B, Kaczmarek LK, Isom LL. More than a pore: ion channel signaling complexes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15159-69. PMID 25392484 DOI: 10.1523/JNEUROSCI.3275-14.2014  0.72
2014 Yuan Y, Isom LL. SUMOylation of Neuronal K⁺ channels: a potential therapeutic pathway for epilepsy and SUDEP? Neuron. 83: 996-8. PMID 25189206 DOI: 10.1016/j.neuron.2014.08.026  0.72
2014 Lin X, O'Malley H, Chen C, Auerbach D, Foster M, Shekhar A, Zhang M, Coetzee W, Jalife J, Fishman GI, Isom L, Delmar M. Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. The Journal of Physiology. PMID 25128572 DOI: 10.1113/jphysiol.2014.277699  0.72
2014 Chopra R, Isom LL. Untangling the dravet syndrome seizure network: the changing face of a rare genetic epilepsy. Epilepsy Currents / American Epilepsy Society. 14: 86-9. PMID 24872787 DOI: 10.5698/1535-7597-14.2.86  0.72
2014 Calhoun JD, Isom LL. The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels. Handbook of Experimental Pharmacology. 221: 51-89. PMID 24737232 DOI: 10.1007/978-3-642-41588-3_4  0.72
2014 Bao Y, Isom LL. NaV1.5 and regulatory β subunits in cardiac sodium channelopathies Cardiac Electrophysiology Clinics. 6: 679-694. DOI: 10.1016/j.ccep.2014.07.002  0.72
2013 Auerbach DS, Jones J, Clawson BC, Offord J, Lenk GM, Ogiwara I, Yamakawa K, Meisler MH, Parent JM, Isom LL. Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome. Plos One. 8: e77843. PMID 24155976 DOI: 10.1371/journal.pone.0077843  0.72
2013 Liu Y, Lopez-Santiago LF, Yuan Y, Jones JM, Zhang H, O'Malley HA, Patino GA, O'Brien JE, Rusconi R, Gupta A, Thompson RC, Natowicz MR, Meisler MH, Isom LL, Parent JM. Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Annals of Neurology. 74: 128-39. PMID 23821540 DOI: 10.1002/ana.23897  0.72
2013 Brackenbury WJ, Yuan Y, O'Malley HA, Parent JM, Isom LL. Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proceedings of the National Academy of Sciences of the United States of America. 110: 1089-94. PMID 23277545 DOI: 10.1073/pnas.1208767110  0.72
2013 Isom L, Patino G, Lopez-Santiago L, Yuan Y. Voltage-gated ion channels Neuroscience in the 21st Century: From Basic to Clinical. 29-58. DOI: 10.1007/978-1-4614-1997-6_3  0.72
2012 Chen C, Calhoun JD, Zhang Y, Lopez-Santiago L, Zhou N, Davis TH, Salzer JL, Isom LL. Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits. The Journal of Biological Chemistry. 287: 39061-9. PMID 22992729 DOI: 10.1074/jbc.M112.397646  0.72
2012 Yang M, Kozminski DJ, Wold LA, Modak R, Calhoun JD, Isom LL, Brackenbury WJ. Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer. Breast Cancer Research and Treatment. 134: 603-15. PMID 22678159 DOI: 10.1007/s10549-012-2102-9  0.72
2012 Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM. The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5716-27. PMID 22539834 DOI: 10.1523/JNEUROSCI.6450-11.2012  0.72
2011 Brackenbury WJ, Isom LL. Na Channel β Subunits: Overachievers of the Ion Channel Family. Frontiers in Pharmacology. 2: 53. PMID 22007171 DOI: 10.3389/fphar.2011.00053  0.72
2011 Patino GA, Brackenbury WJ, Bao Y, Lopez-Santiago LF, O'Malley HA, Chen C, Calhoun JD, Lafrenière RG, Cossette P, Rouleau GA, Isom LL. Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14577-91. PMID 21994374 DOI: 10.1523/JNEUROSCI.0361-11.2011  0.72
2011 Lin X, Liu N, Lu J, Zhang J, Anumonwo JM, Isom LL, Fishman GI, Delmar M. Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 1923-30. PMID 21767519 DOI: 10.1016/j.hrthm.2011.07.016  0.72
2011 Sato PY, Coombs W, Lin X, Nekrasova O, Green KJ, Isom LL, Taffet SM, Delmar M. Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circulation Research. 109: 193-201. PMID 21617128 DOI: 10.1161/CIRCRESAHA.111.247023  0.72
2011 Lopez-Santiago LF, Brackenbury WJ, Chen C, Isom LL. Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo. The Journal of Biological Chemistry. 286: 22913-23. PMID 21555511 DOI: 10.1074/jbc.M111.242370  0.72
2010 O'Malley HA, Park Y, Isom LL, Gnegy ME. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience Letters. PMID 20685611 DOI: 10.1016/j.neulet.2010.05.091  0.72
2010 O'Malley HA, Park Y, Isom LL, Gnegy ME. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience Letters. 480: 40-3. PMID 20641161  0.32
2010 Patino GA, Isom LL. Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease. Neuroscience Letters. 486: 53-9. PMID 20600605 DOI: 10.1016/j.neulet.2010.06.050  0.72
2010 Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H. Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8489-501. PMID 20573896 DOI: 10.1523/JNEUROSCI.1534-10.2010  0.72
2010 Geisler SB, Green KJ, Isom LL, Meshinchi S, Martens JR, Delmar M, Russell MW. Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes. Journal of Biomedicine & Biotechnology. 2010: 624719. PMID 20467587 DOI: 10.1155/2010/624719  0.72
2010 Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 107: 2283-8. PMID 20133873 DOI: 10.1073/pnas.0909434107  0.72
2010 Bai Y, Zhang X, Katona I, Saporta MA, Shy ME, O'Malley HA, Isom LL, Suter U, Li J. Conduction block in PMP22 deficiency. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 600-8. PMID 20071523 DOI: 10.1523/JNEUROSCI.4264-09.2010  0.72
2009 Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Miyazaki H, Nukina N, Oyama F, De Jonghe P, Isom LL. A functional null mutation of SCN1B in a patient with Dravet syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10764-78. PMID 19710327 DOI: 10.1523/JNEUROSCI.2475-09.2009  0.72
2009 Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patiño GA, Taffet SM, Isom LL, Delmar M. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circulation Research. 105: 523-6. PMID 19661460 DOI: 10.1161/CIRCRESAHA.109.201418  0.72
2009 McEwen DP, Chen C, Meadows LS, Lopez-Santiago L, Isom LL. The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin. Neuroscience Letters. 462: 272-5. PMID 19596049 DOI: 10.1016/j.neulet.2009.07.020  0.72
2009 Aman TK, Grieco-Calub TM, Chen C, Rusconi R, Slat EA, Isom LL, Raman IM. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2027-42. PMID 19228957 DOI: 10.1523/JNEUROSCI.4531-08.2009  0.72
2009 Chioni AM, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MB. A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. The International Journal of Biochemistry & Cell Biology. 41: 1216-27. PMID 19041953 DOI: 10.1016/j.biocel.2008.11.001  0.72
2009 O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Molecular and Cellular Neurosciences. 40: 143-55. PMID 19013247 DOI: 10.1016/j.mcn.2008.10.001  0.72
2008 Fein AJ, Wright MA, Slat EA, Ribera AB, Isom LL. scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12510-22. PMID 19020043 DOI: 10.1523/JNEUROSCI.4329-08.2008  0.72
2008 Brackenbury WJ, Djamgoz MB, Isom LL. An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 14: 571-83. PMID 18940784 DOI: 10.1177/1073858408320293  0.72
2008 Brackenbury WJ, Isom LL. Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opinion On Therapeutic Targets. 12: 1191-203. PMID 18694383 DOI: 10.1517/14728222.12.9.1191  0.72
2008 Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL. Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3246-56. PMID 18354028 DOI: 10.1523/JNEUROSCI.5446-07.2008  0.72
2007 Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. Journal of Molecular and Cellular Cardiology. 43: 636-47. PMID 17884088 DOI: 10.1016/j.yjmcc.2007.07.062  0.72
2007 Chen C, Dickendesher TL, Oyama F, Miyazaki H, Nukina N, Isom LL. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b. Genesis (New York, N.Y. : 2000). 45: 547-53. PMID 17868089 DOI: 10.1002/dvg.20324  0.72
2007 Fein AJ, Meadows LS, Chen C, Slat EA, Isom LL. Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant. Bmc Genomics. 8: 226. PMID 17623064 DOI: 10.1186/1471-2164-8-226  0.72
2006 Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I, Isom LL. Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7984-94. PMID 16870743 DOI: 10.1523/JNEUROSCI.2211-06.2006  0.72
2005 Pertin M, Ji RR, Berta T, Powell AJ, Karchewski L, Tate SN, Isom LL, Woolf CJ, Gilliard N, Spahn DR, Decosterd I. Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10970-80. PMID 16306410 DOI: 10.1523/JNEUROSCI.3066-05.2005  0.72
2005 Meadows LS, Isom LL. Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovascular Research. 67: 448-58. PMID 15919069 DOI: 10.1016/j.cardiores.2005.04.003  0.72
2005 Grieco TM, Malhotra JD, Chen C, Isom LL, Raman IM. Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 45: 233-44. PMID 15664175 DOI: 10.1016/j.neuron.2004.12.035  0.72
2004 Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL, Meisler MH. A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10022-34. PMID 15525788 DOI: 10.1523/JNEUROSCI.2034-04.2004  0.72
2004 McEwen DP, Isom LL. Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules. The Journal of Biological Chemistry. 279: 52744-52. PMID 15466474 DOI: 10.1074/jbc.M405990200  0.72
2004 Davis TH, Chen C, Isom LL. Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons. The Journal of Biological Chemistry. 279: 51424-32. PMID 15452131 DOI: 10.1074/jbc.M410830200  0.72
2004 Malhotra JD, Thyagarajan V, Chen C, Isom LL. Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. The Journal of Biological Chemistry. 279: 40748-54. PMID 15272007 DOI: 10.1074/jbc.M407243200  0.72
2004 Hong S, Morrow TJ, Paulson PE, Isom LL, Wiley JW. Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. The Journal of Biological Chemistry. 279: 29341-50. PMID 15123645 DOI: 10.1074/jbc.M404167200  0.72
2004 Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, ... ... Isom LL, et al. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4030-42. PMID 15102918 DOI: 10.1523/JNEUROSCI.4139-03.2004  0.72
2004 McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL. Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. The Journal of Biological Chemistry. 279: 16044-9. PMID 14761957 DOI: 10.1074/jbc.M400856200  0.72
2003 Aronica E, Troost D, Rozemuller AJ, Yankaya B, Jansen GH, Isom LL, Gorter JA. Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies. Acta Neuropathologica. 105: 515-23. PMID 12677453 DOI: 10.1007/s00401-003-0677-2  0.72
2002 Meadows LS, Malhotra J, Loukas A, Thyagarajan V, Kazen-Gillespie KA, Koopman MC, Kriegler S, Isom LL, Ragsdale DS. Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10699-709. PMID 12486163  0.72
2002 Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, ... ... Isom LL, et al. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proceedings of the National Academy of Sciences of the United States of America. 99: 17072-7. PMID 12481039 DOI: 10.1073/pnas.212638099  0.72
2002 Gorter JA, van Vliet EA, Lopes da Silva FH, Isom LL, Aronica E. Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy. The European Journal of Neuroscience. 16: 360-4. PMID 12169118 DOI: 10.1046/j.1460-9568.2002.02078.x  0.72
2002 Malhotra JD, Koopmann MC, Kazen-Gillespie KA, Fettman N, Hortsch M, Isom LL. Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin. The Journal of Biological Chemistry. 277: 26681-8. PMID 11997395 DOI: 10.1074/jbc.M202354200  0.72
2002 Isom LL. The role of sodium channels in cell adhesion. Frontiers in Bioscience : a Journal and Virtual Library. 7: 12-23. PMID 11779698  0.72
2002 Isom LL. Beta subunits: players in neuronal hyperexcitability? Novartis Foundation Symposium. 241: 124-38; discussion 1. PMID 11771642  0.72
2001 Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC. Contactin associates with Na+ channels and increases their functional expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7517-25. PMID 11567041  0.72
2001 Isom LL. Sodium channel beta subunits: anything but auxiliary. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 7: 42-54. PMID 11486343  0.72
2001 Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA. Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron. 30: 105-19. PMID 11343648 DOI: 10.1016/S0896-6273(01)00266-5  0.72
2001 Meadows L, Malhotra JD, Stetzer A, Isom LL, Ragsdale DS. The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit. Journal of Neurochemistry. 76: 1871-8. PMID 11259505 DOI: 10.1046/j.1471-4159.2001.00192.x  0.72
2001 Dhar Malhotra J, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS, Isom LL. Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation. 103: 1303-10. PMID 11238277  0.72
2000 Malhotra JD, Kazen-Gillespie K, Hortsch M, Isom LL. Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. The Journal of Biological Chemistry. 275: 11383-8. PMID 10753953 DOI: 10.1074/jbc.275.15.11383  0.72
2000 Isom LL. I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain? I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain? American Journal of Physiology. Gastrointestinal and Liver Physiology. 278: G349-53. PMID 10712253  0.72
2000 Kazen-Gillespie KA, Ragsdale DS, D'Andrea MR, Mattei LN, Rogers KE, Isom LL. Cloning, localization, and functional expression of sodium channel beta1A subunits. The Journal of Biological Chemistry. 275: 1079-88. PMID 10625649 DOI: 10.1074/jbc.275.2.1079  0.72
1999 Xiao ZC, Ragsdale DS, Malhotra JD, Mattei LN, Braun PE, Schachner M, Isom LL. Tenascin-R is a functional modulator of sodium channel beta subunits. The Journal of Biological Chemistry. 274: 26511-7. PMID 10473612 DOI: 10.1074/jbc.274.37.26511  0.72
1998 McCormick KA, Isom LL, Ragsdale D, Smith D, Scheuer T, Catterall WA. Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit. The Journal of Biological Chemistry. 273: 3954-62. PMID 9461582 DOI: 10.1074/jbc.273.7.3954  0.72
1996 Isom LL, Catterall WA. Na+ channel subunits and Ig domains. Nature. 383: 307-8. PMID 8848042 DOI: 10.1038/383307b0  0.72
1996 Jones JM, Meisler MH, Isom LL. Scn2b, a voltage-gated sodium channel beta2 gene on mouse chromosome 9. Genomics. 34: 258-9. PMID 8661062 DOI: 10.1006/geno.1996.0279  0.72
1995 Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BF, Scheuer T, Catterall WA. Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 83: 433-42. PMID 8521473 DOI: 10.1016/0092-8674(95)90121-3  0.72
1995 Isom LL, Scheuer T, Brownstein AB, Ragsdale DS, Murphy BJ, Catterall WA. Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. The Journal of Biological Chemistry. 270: 3306-12. PMID 7852416 DOI: 10.1074/jbc.270.7.3306  0.72
1995 Qu Y, Isom LL, Westenbroek RE, Rogers JC, Tanada TN, McCormick KA, Scheuer T, Catterall WA. Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits. The Journal of Biological Chemistry. 270: 25696-701. PMID 7592748 DOI: 10.1074/jbc.270.43.25696  0.72
1994 Patton DE, Isom LL, Catterall WA, Goldin AL. The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. The Journal of Biological Chemistry. 269: 17649-55. PMID 8021275  0.72
1994 Isom LL, De Jongh KS, Catterall WA. Auxiliary subunits of voltage-gated ion channels. Neuron. 12: 1183-94. PMID 7516685 DOI: 10.1016/0896-6273(94)90436-7  0.72
1992 Isom LL, De Jongh KS, Patton DE, Reber BF, Offord J, Charbonneau H, Walsh K, Goldin AL, Catterall WA. Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science (New York, N.Y.). 256: 839-42. PMID 1375395  0.72
1987 Isom LL, Cragoe EJ, Limbird LE. Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. The Journal of Biological Chemistry. 262: 6750-7. PMID 2883187  0.72
1987 Isom LL, Cragoe EJ, Limbird LE. Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation. The Journal of Biological Chemistry. 262: 17504-9. PMID 2826423  0.72
1984 Isom LL, Holtzer ME, Holtzer A. α-Helix-to-random-coil transition of two-chain, coiled coils. Experiments on the thermal denaturation of α-tropomyosin and β-tropomyosin Macromolecules. 17: 2445-2447.  0.72
1983 Holtzer A, Isom LL, Holtzer ME. On the realization of the helix-coil theory for protein chains in solutions containing dodecyl sulfate. Experiments on α-tropomyosin and bovine serum albumin Macromolecules. 16: 1063-1068.  0.72
1981 Crimmins DL, Isom LL, Holtzer A. On the preparation and properties of earthworm tropomyosin Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 69: 35-46. DOI: 10.1016/0305-0491(81)90206-6  0.72
Low-probability matches
2016 Frasier CR, Wagnon JL, Bao YO, McVeigh LG, Lopez-Santiago LF, Meisler MH, Isom LL. Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791149 DOI: 10.1073/pnas.1612746113  0.24
2016 Caballero-Florán RN, Conde-Rojas I, Oviedo Chávez A, Cortes-Calleja H, Lopez-Santiago LF, Isom LL, Aceves J, Erlij D, Florán B. Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent. Neuropharmacology. 110: 407-418. PMID 27506997 DOI: 10.1016/j.neuropharm.2016.08.002  0.24
2012 Uebachs M, Albus C, Opitz T, Isom L, Niespodziany I, Wolff C, Beck H. Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia. 53: 1959-67. PMID 23016711 DOI: 10.1111/j.1528-1167.2012.03675.x  0.12
2019 Isom LL, Wilcox KS, Brooks-Kayal A. Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary. Epilepsy Currents. 1535759719858342. PMID 31282199 DOI: 10.1177/1535759719858342  0.01
2019 Isom LL. Is Targeting of Compensatory Ion Channel Gene Expression a Viable Therapeutic Strategy for Dravet Syndrome? Epilepsy Currents. 1535759719844780. PMID 31035820 DOI: 10.1177/1535759719844780  0.01
2019 Lukowski AL, Denomme N, Hinze ME, Hall S, Isom LL, Narayan ARH. Biocatalytic Detoxification of Paralytic Shellfish Toxins. Acs Chemical Biology. PMID 30983320 DOI: 10.1021/acschembio.9b00123  0.01
2018 Edokobi N, Isom LL. Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology. Frontiers in Physiology. 9: 351. PMID 29740331 DOI: 10.3389/fphys.2018.00351  0.01
2017 Isom LL. Opposing Phenotypes in Dravet Syndrome Patient-Derived Induced Pluripotent Stem Cell Neurons: Can Everyone Be Right? Epilepsy Currents. 17: 244-247. PMID 29225534 DOI: 10.5698/1535-7597.17.4.244  0.01
2016 Kaplan DI, Isom LL, Petrou S. Role of Sodium Channels in Epilepsy. Cold Spring Harbor Perspectives in Medicine. PMID 27143702 DOI: 10.1101/cshperspect.a022814  0.01
2010 Xu Y, Isom L, Hanna MA. Adding value to carbon dioxide from ethanol fermentations. Bioresource Technology. 101: 3311-9. PMID 20110166 DOI: 10.1016/j.biortech.2010.01.006  0.01
2005 Hanna MA, Isom L, Campbell J. Biodiesel: Current perspectives and future Journal of Scientific and Industrial Research. 64: 854-857.  0.01
2000 Clay PA, Isom LD, McCloskey WB, Husman SH. Evaluation of ultra narrow cotton production in Arizona 2000 Proceedings Beltwide Cotton Conferences. 657-659.  0.01
1995 Isom LL, Khambatta ZS, Moluf JL, Akers DF, Martin SE. Filament formation in listeria monocytogenes Journal of Food Protection. 58: 1031-1033.  0.01
1995 Isom LL, Ahmed AH, Martin SE. Influence of plasmids on catalase and superoxide dismutase activities in Listeria monocytogenes Journal of Food Protection. 58: 955-959.  0.01
1979 Isom LE. Dynamic evaluation of experimental integral fuel-tank sealants, part 1 0.01
1946 Isom LW. The application of colloid chemistry to the manufacture of inflated articles Journal of Chemical Education. 23: 620-623.  0.01
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