| Year |
Citation |
Score |
| 2025 |
Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. The electrically silent Kv5.1 subunit forms heteromeric Kv2 channels in cortical neurons and confers distinct functional properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 39933932 DOI: 10.1523/JNEUROSCI.2293-23.2025 |
0.482 |
|
| 2024 |
Stewart RG, Marquis MJ, Jo S, Ferns M, Sack JT. KvS regulatory subunits confer drug resistance to Kv2 channels. Biorxiv : the Preprint Server For Biology. PMID 38352561 DOI: 10.1101/2024.01.31.578214 |
0.529 |
|
| 2024 |
Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function. Biorxiv : the Preprint Server For Biology. PMID 38328147 DOI: 10.1101/2024.01.25.577135 |
0.479 |
|
| 2023 |
Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of hERG channel-drug interactions using Rosetta. Frontiers in Pharmacology. 14: 1244166. PMID 38035013 DOI: 10.3389/fphar.2023.1244166 |
0.448 |
|
| 2023 |
Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na1.7. Frontiers in Pharmacology. 14: 1156855. PMID 37007002 DOI: 10.3389/fphar.2023.1156855 |
0.428 |
|
| 2022 |
Nguyen PT, Nguyen HM, Wagner KM, Stewart R, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, et al. Computational design of peptides to target Na1.7 channel with high potency and selectivity for the treatment of pain. Elife. 11. PMID 36576241 DOI: 10.7554/eLife.81727 |
0.305 |
|
| 2022 |
Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13: 966463. PMID 36188564 DOI: 10.3389/fphar.2022.966463 |
0.458 |
|
| 2022 |
Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Molecular Pharmacology. PMID 36041862 DOI: 10.1124/molpharm.122.000569 |
0.443 |
|
| 2022 |
Marquis MJ, Sack JT. Mechanism of use-dependent Kv2 channel inhibition by RY785. The Journal of General Physiology. 154. PMID 35435946 DOI: 10.1085/jgp.202112981 |
0.55 |
|
| 2022 |
Sepela RJ, Stewart RG, Valencia LA, Thapa P, Wang Z, Cohen BE, Sack JT. The AMIGO1 adhesion protein activates Kv2.1 voltage sensors. Biophysical Journal. PMID 35314141 DOI: 10.1016/j.bpj.2022.03.020 |
0.768 |
|
| 2022 |
Sack JT. K takes the crown: Selective activation of non-selective crown ether channels. Biophysical Journal. 121: 863-864. PMID 35219397 DOI: 10.1016/j.bpj.2022.02.020 |
0.318 |
|
| 2021 |
Thapa P, Stewart R, Sepela RJ, Vivas O, Parajuli LK, Lillya M, Fletcher-Taylor S, Cohen BE, Zito K, Sack JT. EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues. The Journal of General Physiology. 153. PMID 34581724 DOI: 10.1085/jgp.202012858 |
0.779 |
|
| 2021 |
Stewart R, Cohen BE, Sack JT. Fluorescent toxins as ion channel activity sensors. Methods in Enzymology. 653: 295-318. PMID 34099176 DOI: 10.1016/bs.mie.2021.02.014 |
0.557 |
|
| 2021 |
Maly J, Emigh AM, DeMarco K, Sack JT, Vorobyov IV, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions Biophysical Journal. 120: 243a. DOI: 10.1016/j.bpj.2020.11.1595 |
0.348 |
|
| 2020 |
Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. Acs Chemical Neuroscience. PMID 32579336 DOI: 10.1021/Acschemneuro.0C00276 |
0.8 |
|
| 2020 |
Thapa P, Fletcher-Taylor S, Sepela RJ, Yarov-Yarovoy V, Sack JT, Cohen BE. Observation of Multiple Potassium Channel Closed State Structures by Voltage Clamp Spectroscopy Biophysical Journal. 118: 262a. DOI: 10.1016/J.Bpj.2019.11.1520 |
0.786 |
|
| 2020 |
Marquis MJ, Nguyen M, Sack JT. Inhibition of the Voltage-Gated Potassium Channel KV2.1 by RY785, a Kv2-Selective Small Molecule Biophysical Journal. 118: 262a. DOI: 10.1016/j.bpj.2019.11.1519 |
0.492 |
|
| 2020 |
Maly J, Emigh AM, DeMarco K, Sack JT, Vorobyov IV, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions Biophysical Journal. 118: 212a. DOI: 10.1016/J.Bpj.2019.11.1265 |
0.348 |
|
| 2019 |
Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. Facilitation of current by some hERG channel blockers suppresses early afterdepolarizations. The Journal of General Physiology. PMID 30674563 DOI: 10.1085/jgp.201812192 |
0.371 |
|
| 2019 |
Islas LD, Miller C, Sack JT. Decision letter: Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states Elife. DOI: 10.7554/Elife.46170.017 |
0.381 |
|
| 2019 |
Maly J, Emigh AM, DeMarco KR, Sack JT, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the HERG Channel in an Inactivated State and its Drug Interactions Biophysical Journal. 116: 104a. DOI: 10.1016/j.bpj.2018.11.598 |
0.356 |
|
| 2019 |
Marquis MJ, Sepela RJ, Sack JT. Decoupling between Voltage Sensor Movement and Pore Opening of Kv2.1 Channels Biophysical Journal. 116: 543a. DOI: 10.1016/J.BPJ.2018.11.2918 |
0.781 |
|
| 2019 |
Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov IV, Yarov-Yarovoy V. Structural Modeling of Drug Interactions with hERG Channel in Open and Closed States Biophysical Journal. 116: 249a-250a. DOI: 10.1016/J.Bpj.2018.11.1363 |
0.362 |
|
| 2018 |
Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. The tarantula toxin GxTx detains K channel gating charges in their resting conformation. The Journal of General Physiology. PMID 30397012 DOI: 10.1085/Jgp.201812213 |
0.527 |
|
| 2018 |
Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Molecular Biology of the Cell. mbcE18050337. PMID 30091655 DOI: 10.1091/mbc.E18-05-0337 |
0.338 |
|
| 2018 |
Sepela RJ, Sack JT. Taming unruly chloride channel inhibitors with rational design. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735705 DOI: 10.1073/pnas.1805589115 |
0.762 |
|
| 2018 |
Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich R, Andersen OS, Sack JT. Synthetic analogs of the snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT) reveal that lipid bilayer perturbation does not underlie its modulation of voltage-gated potassium channels. Biochemistry. PMID 29616558 DOI: 10.1021/Acs.Biochem.8B00292 |
0.645 |
|
| 2018 |
Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V. Assessing the Structural Basis of μ-Conotoxin KIIIA Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.3431 |
0.505 |
|
| 2018 |
Emigh AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural Modeling of hERG Channel Interactions with Drugs using Rosetta Biophysical Journal. 114: 486a. DOI: 10.1016/J.Bpj.2017.11.2667 |
0.349 |
|
| 2018 |
Thapa P, Sepela R, Stewart R, Lillya M, Vivas O, Parajuli L, Fletcher-Taylor S, Zito K, Cohen BE, Sack J. Imaging Voltage Gating of Endogenous Neuronal Ion Channels with Fluorescent Tarantula Toxin Biophysical Journal. 114: 478a-479a. DOI: 10.1016/J.Bpj.2017.11.2631 |
0.775 |
|
| 2018 |
Fletcher-Taylor S, Thapa P, Sack JT, Cohen BE. Observation of Structural Changes in Closed K+ Channels by Voltage Clamp Spectroscopy Biophysical Journal. 114: 475a. DOI: 10.1016/J.Bpj.2017.11.2613 |
0.469 |
|
| 2018 |
Furutani K, Tsumoto K, Sack JT, Kurachi Y. Facilitation by hERG Channel Blockers Suppresses Early Afterdepolarization of Simulated Cardiac Action Potentials Biophysical Journal. 114: 474a. DOI: 10.1016/J.BPJ.2017.11.2607 |
0.346 |
|
| 2017 |
Sepela RJ, Sherlock BE, Tian L, Marcu L, Sack J. A strategy to measure electrophysiological changes with photoacoustic imaging (Conference Presentation) Proceedings of Spie. 10064. DOI: 10.1117/12.2251050 |
0.753 |
|
| 2017 |
Tilley DC, Eum KS, Sack JT. The Tarantula Toxin Guangxitoxin-1E Traps K + Channel Voltage Sensor in a Fully Resting Conformation Biophysical Journal. 112: 162a-163a. DOI: 10.1016/J.BPJ.2016.11.894 |
0.446 |
|
| 2017 |
Dockendorff C, Gandhi D, Kimball I, Eum KS, Rusinova R, Ingólfsson H, Kapoor R, Peyear T, Martin SF, Aldrich RW, Andersen OS, Sack J. Lipid Bilayer Perturbation by the Snail Toxin 6-Bromo-2-Mercaptotryptamine Dimer does not Account for its Modulation of Voltage-Gated Potassium Channels Biophysical Journal. 112: 246a-247a. DOI: 10.1016/J.Bpj.2016.11.1348 |
0.713 |
|
| 2017 |
Fletcher-Taylor S, Lillya MW, Thapa P, Cohen BE, Sack JT. Polarity of the Chemical Environment Surrounding Potassium Channel Voltage Sensors Detected by Solvatochromic Dye-Tarantula Toxin Conjugates Biophysical Journal. 112: 246a. DOI: 10.1016/J.Bpj.2016.11.1346 |
0.452 |
|
| 2017 |
Kimball IH, Nguyen PT, Yam J, Pressly B, York R, Sack JT, Yarov-Yarovoy V. Tarantula Toxin SGTx-1 alters Gating Kinetics of Human Voltage-Gated Sodium Channel Nav1.7 Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1316 |
0.525 |
|
| 2016 |
Tilley DC, Fleishman S, Sack JT, Yarov-Yarovoy V. What Determines the Charybdotoxin Specificity Among Kv1 Potassium Channels? Biophysical Journal. 110: 106a-107a. DOI: 10.1016/J.Bpj.2015.11.631 |
0.452 |
|
| 2016 |
Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Exploring Structural Interactions of Tarantula Toxins with Lipid Membranes using Rosetta and Molecular Dynamics Simulation Biophysical Journal. 110: 447a. DOI: 10.1016/J.Bpj.2015.11.2404 |
0.389 |
|
| 2016 |
Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V. Mapping the Nav1.7 Channel Interaction with the Conotoxin KIIIA Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2358 |
0.472 |
|
| 2016 |
Lillya MW, Parajuli LK, Fletcher-Taylor S, Huang J, Cohen BE, Zito K, Sack JT. Optical Recording of Voltage Activation of Endogenous Potassium Channels Biophysical Journal. 110: 344a. DOI: 10.1016/J.Bpj.2015.11.1853 |
0.532 |
|
| 2015 |
Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. The Journal of General Physiology. 146: 399-410. PMID 26503721 DOI: 10.1085/jgp.201511444 |
0.433 |
|
| 2015 |
Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty. The Journal of General Physiology. 146: 123-7. PMID 26216857 DOI: 10.1085/jgp.201511469 |
0.465 |
|
| 2015 |
Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Vladimir YY, Kim JI, Swartz KJ. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 4: e06774. PMID 25948544 DOI: 10.7554/Elife.06774 |
0.376 |
|
| 2015 |
Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/Jphysiol.2014.281428 |
0.648 |
|
| 2015 |
Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Author response: Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels Elife. DOI: 10.7554/Elife.06774.017 |
0.36 |
|
| 2015 |
Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty Journal of General Physiology. 146: 123-127. DOI: 10.1085/jgp.201511469 |
0.465 |
|
| 2015 |
Nguyen PT, Kimball IH, Eum KS, Cohen BE, Sack JT, Yarov-Yarovoy V. Understanding the State Dependence of Voltage Sensor Toxin Action on Voltage Gated Sodium Channels Biophysical Journal. 108: 574a. DOI: 10.1016/J.Bpj.2014.11.3139 |
0.49 |
|
| 2014 |
Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E4789-96. PMID 25331865 DOI: 10.1073/Pnas.1406876111 |
0.538 |
|
| 2014 |
Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Structural Modeling of Toxin Interactions with the Human Voltage-Gated Sodium Channel Pore Biophysical Journal. 106: 130a. DOI: 10.1016/J.Bpj.2013.11.768 |
0.475 |
|
| 2014 |
Eum KS, Fletcher-Taylor S, Austin D, Cohen BE, Sack JT. Tethering Dimers of Voltage Sensor Toxins can Selectively Amplify their Affinity for Kv Channels Biophysical Journal. 106: 89a-90a. DOI: 10.1016/J.Bpj.2013.11.568 |
0.474 |
|
| 2014 |
Zamanian M, Bae C, Tilley D, Gupta K, Sack J, Yarov-Yarovoy V, Kim JI, Swartz K. Common Interaction Surfaces for Tarantula Toxins Targeting Kv and ASIC Channels Biophysical Journal. 106: 737-738. DOI: 10.1016/J.Bpj.2013.11.4065 |
0.542 |
|
| 2014 |
Tilley DC, Kaakati R, Yarov-Yarovoy V, Sack JT. Rosetta Structural Modeling of Tarantula Toxin Binding to Voltage Sensors Biophysical Journal. 106: 737a. DOI: 10.1016/J.Bpj.2013.11.4064 |
0.397 |
|
| 2013 |
Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. Antibody-guided photoablation of voltage-gated potassium currents. The Journal of General Physiology. 142: 315-24. PMID 23940262 DOI: 10.1085/Jgp.201311023 |
0.476 |
|
| 2013 |
Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Structural Modeling of the Human Nav1.7 Sodium Channel Pore Biophysical Journal. 104: 137a. DOI: 10.1016/J.Bpj.2012.11.783 |
0.453 |
|
| 2013 |
Ingólfsson HI, Thakur P, Herold KF, Maretzky T, Hall K, Zwama M, Yilmaz D, Hemmings HC, Blobel C, Koçer A, Sack J, Andersen OS. Phytochemicals Promiscuously Alter Membrane Protein Function and Bilayer Properties Biophysical Journal. 104: 93a. DOI: 10.1016/J.Bpj.2012.11.557 |
0.413 |
|
| 2013 |
Tilley DC, Eum KS, Cohen BE, Yarov-Yarovoy V, Sack JT. Fluorescently Labeled Tarantula Toxin Reveals Voltage Dependent Adhesion to K+ Channels Biophysical Journal. 104: 197a. DOI: 10.1016/J.Bpj.2012.11.1111 |
0.578 |
|
| 2012 |
Eum KS, Angueyra JM, Kim H, Chao L, Cohen BE, Sack JT. Allosteric Stabilization of Fully Resting Voltage Sensors by a Tarantula Toxin Biophysical Journal. 102: 531a. DOI: 10.1016/J.Bpj.2011.11.2903 |
0.506 |
|
| 2011 |
Mandikian D, Cerda O, Sack JT, Trimmer JS. A SUMO-Phospho tag team for wrestling with potassium channel gating. The Journal of General Physiology. 137: 435-9. PMID 21518832 DOI: 10.1085/Jgp.201110648 |
0.531 |
|
| 2010 |
Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO. Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. The Journal of General Physiology. 136: 273-82. PMID 20805574 DOI: 10.1085/Jgp.200910398 |
0.413 |
|
| 2010 |
Sack JT, Stephanopoulos N, Trimmer JS. Arming Antibodies for Subtype-Selective Photo-Inhibition of Voltage Gated Potassium Channels Biophysical Journal. 98: 318a. DOI: 10.1016/j.bpj.2009.12.1725 |
0.363 |
|
| 2008 |
Sack JT, Shamotienko O, Dolly JO. How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. The Journal of General Physiology. 131: 415-20. PMID 18411330 DOI: 10.1085/jgp.200709939 |
0.322 |
|
| 2007 |
Sokolov MV, Shamotienko O, Dhochartaigh SN, Sack JT, Dolly JO. Concatemers of brain Kv1 channel alpha subunits that give similar K+ currents yield pharmacologically distinguishable heteromers. Neuropharmacology. 53: 272-82. PMID 17637465 DOI: 10.1016/j.neuropharm.2007.05.008 |
0.446 |
|
| 2006 |
Sack JT, Aldrich RW. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. The Journal of General Physiology. 128: 119-32. PMID 16801385 DOI: 10.1085/jgp.200609492 |
0.702 |
|
| 2004 |
Sack JT, Aldrich RW, Gilly WF. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. The Journal of General Physiology. 123: 685-96. PMID 15148327 DOI: 10.1085/jgp.200409047 |
0.716 |
|
| 2003 |
Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. The Journal of Biological Chemistry. 278: 34934-42. PMID 12815055 DOI: 10.1074/Jbc.M301271200 |
0.417 |
|
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